Strain Name: |
RHJ/Le |
|---|---|
Stock Number: |
000266 |
Availability: | Repository-Cryopreserved |
Price and Supply Information | |
General Terms and Conditions |
| Genes & Alleles | Hr; Hrrh-J; |
Product Information
Strain Details
Type Inbred Strain Additional information on Inbred Strains. Type JAX® GEMM® Strain - Spontaneous Mutation Additional information on JAX® GEMM® Strains. Species laboratory mouse Generation F59 Appearance
albino
Related Genotype: a/a Tyrp1b/Tyrp1b Tyrc/TyrcImportant Note
This strain is segregating for Hrrh-J.Strain Description
Rhino mice have spleen cells with a defective response to T-dependent antigens and they develop an autoimmune disease characterized by hypergammaglobulinemia, immunoglobulin deposits in basement membrane of skin, spleen, liver, and kidney, and presence of antinuclear antibodies which occur in young mice and increase with age. These mice have increased numbers of Thy1 positive epidermal dendritic cells. Like homozygous hairless mice, rhino mice are hairless by 5 weeks and their skin becomes wrinkled and thickened.Strain Development
The rhino Jackson mutation (Hrrh-J) was found at Carworth Farms (a New York commercial breeder) in a stock of undetermined genetic background and sent to The Jackson Laboratory in 1951. It was outcrossed to BALB/cHu for 6 generations and then sibling mated. At F15 in 1963 it was outcrossed to the albino hook (Hk) stock, which had C57BL/6J, AKR and A/Sn in its background, and was again sibling mated selecting away from hook. The stock was nonagouti (a/a), brown (Tyrp1b), albino (Tyrc) and carrying rhino Jackson (Hrrh-J). It was maintained by mating heterozygous (haired) females to rhino Jackson homozygous males and reached F96 in 1990. This same stock is also in the production facility as RHJ/LeJ (Stock No. 001591) and is also maintained by mating haired females by affected males. It was cryopreserved by mating heterozygous females to homozygous males at F76.
Gene & Allele Details
| Allele Symbol | Hrrh-J | ||
|---|---|---|---|
| Allele Name | rhino Jackson | ||
| Gene Symbol and Name | Hr, hairless | ||
| Chromosome | 14 | ||
| Gene Common Name(s) | ALUNC; AU; HSA277165; N; ba; baldy; bldy; rh; rh-bmh; rhino-bald Mill Hill; | ||
Control Information
| Control | ||
|---|---|---|
| Heterozygote from the colony | ||
| Considerations for Choosing Controls | ||
| Control Pricing Information for JAX® GEMM® Strains | ||
Colony Maintenance
| Diet Information | LabDiet® 5K52/5K67 |
|---|
Related Strains
Strains carrying Hrrh-J allele
001591 RHJ/LeJ View Strains carrying Hrrh-J (1 strain)
007621 B6.129S6-Hrtm1Cct/J 001737 B6.A-H2-T18a.HRS-Hrhr/J 007622 B6;SJL-Tg(KRT14-Hr)551Cct/J 000758 C57BL/6J-Hbbp Hrrh-7J/J 002922 D2.HRS-Hrhr/J 000673 HRS/J 001103 HRS/J-Hrhr Esdb/+ Esdb/J 002335 SKH2/J 000147 WLHR/LeJ
Additional Web Information
JAX® NOTES, January 1989; 436. Phenotypic abnormalities in hr-locus mutants.
JAX® NOTES, January 1989; 436. References for the Rhino Allele.
JAX® NOTES, October 1988; 435. Introduction of Rhino (hrrh) into Jackson Laboratory Production Colonies.
Research Applications
This mouse can be used to support research in many areas including:Hrrh-J related
Immunology and Inflammation Research
Immunodeficiency Associated with Other Defects
Research Tools
Toxicology Research
References
Additional ReferencesPrice and Supply Information
| Strain Name: | RHJ/Le |
| Stock Number: | 000266 |
Price Details
IMPORTANT NOTE: Prices are based on shipping destination. The shipping destinations are:
- USA, Canada and Mexico
- International
*Pricing for Shipping Destination selected:
International
| Price(s) in US dollars ($) | |||||
|---|---|---|---|---|---|
| Cryorecovery Fee | $2470.00 | ||||
Supply Details
| Standard Supply | Repository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information. |
|---|---|
| Supply Notes |
Cryorecovery - Standard. The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two males and two females (two pairs) will be provided, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the delivery time to approximately 25 weeks. At least one member of each pair will be of known genotype and will carry the mutation if it is a mutant strain. Please note that pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Price represents a repository maintenance fee, which includes the cost of recovery of the strain from the cryopreservation resource and the periodic replacement of the frozen embryos used for recovery. Cryorecovery to establish a Dedicated Supply for greater quantities of mice. |
| Licensing | See General Terms and Conditions below |
| Control Information | View Control Information in Strain Details. View Control Pricing Information for JAX® Strains. |
General Terms and Conditions
View JAX® Mice & Services Conditions of Use.
The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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