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Strain Name:

SEC/1GnLeJ

Stock Number:

000270

Availability:

Repository-Cryopreserved

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General Terms and Conditions

Genes & Alleles   Bmp5;   Bmp5se;

Product Information

Strain Details

Type Inbred Strain
Additional information on Inbred Strains.
Type JAX® GEMM® Strain - Spontaneous Mutation
Additional information on JAX® GEMM® Strains.
Specieslaboratory mouse
GenerationF162

Appearance
pink-eyed chinchilla
Related Genotype: a/a Tyrp1b/Tyrp1b Tyrc-ch/Tyrc-ch

Important Note
This strain is segregating for Bmp5se.

Related Disease (OMIM) Terms

Ear, Patella, Short Stature Syndrome
Mammalian Phenotype Terms assigned by genotype

Bmp5se/Bmp5se

        SEC/1Gn
  • skeleton phenotype
  • abnormal cartilage development (MGI Ref ID J:13011)
    • cartilage forms more slowly in healing rib fractures
  • cardiovascular system phenotype
  • abnormal artery morphology (MGI Ref ID J:5086)
    • the right renal artery lies ventral to the posterior vena cava rather than dorsal to it as in controls
  • immune system phenotype
  • granulomatous inflammation (MGI Ref ID J:5086)
    • granulomas are seen on the ventral surface of the central and left lateral lobes of the liver
  • liver/biliary system phenotype
  • abnormal liver morphology (MGI Ref ID J:5086)
    • increase in liver lesions, mainly due to an increase in granulomas
  • respiratory system phenotype
  • lung cysts (MGI Ref ID J:5086)
    • have numerous small cysts in the lungs

Gene & Allele Details

Allele Symbol Bmp5se
Allele Name short ear
Common Name(s) seGnJ;
Strain of Originmice from Abbie Lathrop mouse farm
Gene Symbol and Name Bmp5, bone morphogenetic protein 5
Chromosome 9
Gene Common Name(s) AU023399; MGC34244; expressed sequence AU023399; se; short ear;
Molecular Note The C to T transition creates a stop codon at amino acid 208. The resulting truncated protein does not include the carboxy terminal signaling portion of the molecule. [MGI Ref ID J:21484]

Control Information

  Control
   Heterozygote from the colony
 
  Considerations for Choosing Controls

Related Strains

Strains carrying   Bmp5se allele
000004   ABP/LeJ
000578   B6 x STOCK Tyrc-ch Bmp5se +/+ Myo6sv/J
000056   B6.Cg-Bmp5se/J
000285   B6.Cg-Rorasg + +/+ Myo5ad Bmp5se/J
000253   DLS/LeJ
000644   SEA/GnJ
View Strains carrying   Bmp5se     (6 strains)

Strains carrying other alleles of Bmp5
001496   C57BL/6J-Bmp5se-4J/J
005420   C;129S7 Gt(ROSA)26Sor-Bmp5cfe-se7J/J
005421   CBy;B6-Bmp5cfe-se8J/J
View Strains carrying other alleles of Bmp5     (3 strains)

Research Applications

This mouse can be used to support research in many areas including:

Bmp5se related

Developmental Biology Research
Growth Defects
Skeletal Defects

References

Additional References

Price and Supply Information

Strain Name: SEC/1GnLeJ
Stock Number: 000270

Price Details

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Supply Details

Standard SupplyRepository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information.
Supply Notes Cryorecovery - Standard.
The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two males and two females (two pairs) will be provided, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the delivery time to approximately 25 weeks. At least one member of each pair will be of known genotype and will carry the mutation if it is a mutant strain. Please note that pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Price represents a repository maintenance fee, which includes the cost of recovery of the strain from the cryopreservation resource and the periodic replacement of the frozen embryos used for recovery.

Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
One to two pairs will be recovered to establish a Dedicated Supply of mice. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services: Tel: 1-800-422-6423 or 1-207-288-5845; Email: jaxservices@jax.org.
Genomic DNA is available for this strain from the Mouse DNA Resource.

LicensingSee General Terms and Conditions below  
Control InformationView Control Information in Strain Details.

General Terms and Conditions

View JAX® Mice & Services Conditions of Use.

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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