Strain Name: |
SH1/LeJ |
|---|---|
Stock Number: |
000271 |
Availability: | Repository-Cryopreserved |
General Terms and Conditions |
| Genes & Alleles | Myo7a; Myo7ash1; Tyr; Tyrc-ch; |
Type Inbred Strain Additional information on Inbred Strains. Type JAX® GEMM® Strain - Spontaneous Mutation Additional information on JAX® GEMM® Strains. Species laboratory mouse Generation F97p Appearance
chinchilla, circles
Related Genotype: Tyrc-ch Myo7ash1/Tyrc-ch Myo7ash1
chinchilla, unaffected
Related Genotype: Tyrc-ch Myo7ash1/Tyrc-ch +Important Note
This strain is homozygous for Tyrc-ch and segregating for Myo7ash1.Strain Description
Mice homozygous for the shaker 1 spontaneous mutation (Myo7ash1) show circling, head-tossing, deafness, and hyperactivity characteristic of this type of mutant mice. Viability is normal, and breeding ability is high for a circling mutant. Homozygous mutant mice are most often deaf and swim well on the surface of water up to 4 weeks of age and more but lose the ability later. The degenerative changes of the labyrinth may occur a little later than in some of the other waltzing mutants. By light microscopy, the changes are seen to consist of degeneration of the organ of Corti, the spiral ganglion, and the stria vascularis in the cochlea, and of the saccular macula and the vestibular ganglion in the vestibular labyrinth.Strain Development
The shaker 1 (Myo7ash1) strain originated in 1957 with two FS/Ei siblings at F5 mated. One sibling was also mated to a C57BL/6J and the offspring of the two FS/Ei mice were mated to a C3HeB/FeJ. Several within stock matings were made from both crosses and 2 siblings were each mated to a C3HeB/FeJ. Two generations were stock bred and the chinchilla shaker1 genotype was selected for inbreeding with the Myo7ash1 locus segregating. It was cryopreserved in 1989 by mating chinchilla shaker1 (Tyrc-ch Myo7ash1/Tyrc-ch Myo7ash1) males to chinchilla but shaker1 heterozygous (Tyrc-ch Myo7ash1/Tyrc-ch +) females at F96.
Related Disease (OMIM) Terms |
Mammalian Phenotype Terms assigned by genotype |
| Allele Symbol | Myo7ash1 | ||
|---|---|---|---|
| Allele Name | shaker 1 | ||
| Common Name(s) | sh1; shaker-1; | ||
| Strain of Origin | BALB at F12 | ||
| Gene Symbol and Name | Myo7a, myosin VIIa | ||
| Chromosome | 7 | ||
| Gene Common Name(s) | DFNA11; DFNB2; MYOVIIA; MYU7A; Myo7; NSRD2; USH1B; myosin VII; neuroscience mutagenesis facility, 371; nmf371; sh-1; sh1; shaker 1; | ||
| Molecular Note | A G-to-C transversion mutation is predicted to result in an arginine to proline change at position 502 in the encoded protein. This mutation is predicted to lie within the head domain of the protein. Northern blot analysis indicated that mRNA expression, size, and stability were unaffected. Immunoblot analysis showed that normal levels of the protein was expressed. [J:23257] | ||
| Allele Symbol | Tyrc-ch | ||
| Allele Name | chinchilla | ||
| Common Name(s) | cch; cr; | ||
| Strain of Origin | fancier's stock | ||
| Gene Symbol and Name | Tyr, tyrosinase | ||
| Chromosome | 7 | ||
| Gene Common Name(s) | C; OCA1A; OCAIA; SHEP3; albino; c; skc35; skin/coat color 35; | ||
| Molecular Note | The mutation in the chinchilla allele was found to be a G to A point mutation that results in an amino acid change at position 464 from alanine to threonine. [J:19279] | ||
| Allele | Control | |
|---|---|---|
| Myo7ash1 | Heterozygote from the colony | |
| Considerations for Choosing Controls | ||
Strains carrying Myo7ash1 allele
000619 FS/EiJ View Strains carrying Myo7ash1 (1 strain)
Strains carrying Tyrc-ch allele
000091 129T1/Sv-Oca2+ Tyrc-ch Dnd1Ter/J 001279 129T1/Sv-Oca2+ Tyrc-ch-Aft/J 000578 B6 x STOCK Tyrc-ch Bmp5se +/+ Myo6sv/J 000619 FS/EiJ 004828 FVB.129P2-Pde6b+ Tyrc-ch/AntJ 000306 STOCK Dll3pu + Tyrc-ch/+ Oca2p Tyrc-ch/J View Strains carrying Tyrc-ch (6 strains)
Strains carrying other alleles of Myo7a
003184 B6.Cg-Myo7ash1-8J/J 005468 C57BL/6J-Myo7ash1-11J/J 002919 STOCK Myo7ash1-7J/J View Strains carrying other alleles of Myo7a (3 strains)
Strains carrying other alleles of Tyr
000090 129S1/Sv-Oca2+ Tyr+ KitlSl-J/J 005445 A.B6 Tyr+-Cybanmf333/J 005012 A.B6 Tyr+-Myo5ad-l31J/J 002565 A.B6-Tyr+/J 000409 B10.129P-H1b Hbbd Tyrc Ea7a/(5M)oSnJ 000418 B10.129P-H1b Tyrc Hbbd/(5M)nSnJ 000432 B10.C-H1b Hbbd Tyrc/(41N)SnJ 000580 B10.D2/nSn-Tyrc-4J/J 000822 B6 x 129S1/SvEi Oca2+ Tyr+-Vsx2or-J/J 000058 B6(Cg)-Tyrc-2J/J 000383 B6.C-Tyrc H1b Hbbd/ByJ 007484 B6.Cg-Tyrc-2J Tg(Tyr)3412ARpw Tg(Sry-EGFP)92Ei/EiJ 000035 B6.Cg-Tyrc-J/J 000104 B6.Cg-Tyrc-h/J 000054 B6.D2-Tyrc-p/J 000899 C.B6-Tyr+ Hbbs/J 000339 C3H/HeJ-Tyrc-9J/J 001294 C3H/HeJ-Tyrc-a/J 001002 C57BL/10SnJ-Tyrc-11J/J 001006 CBA/J-Tyrc-10J/J 000657 CE/J 007483 FVB.Cg-Tg(Tyr)3412ARpw Tg(Sry-EGFP)92Ei/EiJ 000494 J.Cg-Oca2+ Tyr+ Lystbg/J 002281 NFS.C58-Tyr+/J 004304 NOD.CBALs-Tyr+/LtJ 005115 NOD.FVB-Tg(INS-MT2A,Tyr)1Pne/PneJ 005114 NOD.FVB-Tg(Ins1-Cat,Tyr)25Pne/PneJ 001759 STOCK A Tyrc Sha/J 000006 STOCK Hk Tyrc/J 000206 STOCK a/a Tyrc-h/J View Strains carrying other alleles of Tyr (30 strains)
Myo7ash1 related
Tyrc-ch relatedDermatology Research
Color and White Spotting Defects (oculocutaneous albinism, type I)
Mouse/Human Gene Homologs
Usher syndrome, type IB (deafness, neurosensory, autosomal recessive, 2, and deafness, autosomal dominant nonsyndromic sensorineural, 11)
Neurobiology Research
Tremor Defects
Vestibular and Hearing Defects
Sensorineural Research
Vestibular and Hearing Defects
Dermatology Research
Color and White Spotting Defects
Developmental Biology Research
Neurodevelopmental Defects
Skeletal Defects
Mouse/Human Gene Homologs
albinism, tyrosine negative
| Strain Name: | SH1/LeJ |
| Stock Number: | 000271 |
IMPORTANT NOTE: Prices are based on shipping destination. To view prices, select your shipping destination.
| Standard Supply | Repository-Cryopreserved. Must Be Recovered. Please refer to the Supply Notes for further information. |
|---|---|
| Supply Notes |
Cryorecovery - Standard. The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two males and two females (two pairs) will be provided, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the delivery time to approximately 25 weeks. At least one member of each pair will be of known genotype and will carry the mutation if it is a mutant strain. Please note that pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Price represents a repository maintenance fee, which includes the cost of recovery of the strain from the cryopreservation resource and the periodic replacement of the frozen embryos used for recovery. Cryorecovery to establish a Dedicated Supply for greater quantities of mice. |
| Licensing | See General Terms and Conditions below |
| Control Information | View Control Information in Strain Details. |
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