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Strain Name:

TSJ/LeJ

Stock Number:

000274

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General Terms and Conditions

Former Name      TSJ/Le Ts    (Changed: 27-MAR-08 )
      TSJ/Le-Tyrp1b Ts    (Changed: 27-MAR-08 )
      TSJ/Le Ts/+    (Changed: 15-DEC-04 )
      TSJ/Le-Tyrp1b/Tyrp1b Ts/+    (Changed: 15-DEC-04 )
Genes & Alleles   Ts;   Tyrp1;   Tyrp1b;

Product Information

Strain Details

Type Inbred Strain
Additional information on Inbred Strains.
Type Segregating Inbred
Type JAX® GEMM® Strain - Spontaneous Mutation
Additional information on JAX® GEMM® Strains.
Mating SystemHeterozygote x +/+ sibling         (Female x Male)
Specieslaboratory mouse
GenerationF130 (06-DEC-07)

Appearance
agouti brown, tail defects
Related Genotype: A/A Tyrp1b/Tyrp1b Ts/+

agouti brown, normal tail
Related Genotype: A/A Tyrp1b/Tyrp1b +/+

Important Note
This strain is homozygous for Tyrp1b and segregating for Ts.

Strain Development
The Ts mutation arose spontaneously in 1946 at the National Cancer Institute in BALB/c (strain C of the Bagg albino strain) when that inbred was at generation F63. W.C. Morgan gave this mutant subline to George Snell at The Jackson Laboratory in 1950 and Snell outcrossed it to C57BL/6, C56BR/a, and BALB/cSn before inbreeding began on this new background and the line was transferred to Skippy Lane. The TSJ/Le inbred reached generation F41 in 1979 and F130 in 2007.

Mammalian Phenotype Terms assigned by genotype

Ts/Ts+

        TSJ/Le
  • embryogenesis phenotype
  • abnormal embryonic erythropoiesis (MGI Ref ID J:6184)
    • embryonic day 12-14 primitive nucleated erythrocytes have less hemoglobin content per cell than normal
    • embryonic day 11-13 primitive nucleated erythrocytes have increased mitotic indices
    • embryonic day 13 only 7% of the circulating cells are small non-nucleated erythrocytes compared with one third of the circulating cells in wildtype controls
    • delayed fetal hepatic erythropoiesis wherein embyronic day 12 mutants have primarily immature erythroid precursors and wildtype controls have many immature and mature erythroblasts
  • embryonic growth retardation (MGI Ref ID J:6184)
    • at embryonic day 11 mutants and wildtype can not be readily distinguished by growth retardation, but at embryonic day 12 mutants are clearly smaller and an approximately 1 day delay in development persists and is evident in reduced fetal weight and placental weight
    • although the total hemoglobin content is lower in age matched mutant and wildtype embryos the ratio of hemoglobin content to embryo weight is normal indicating that the diminished hemoglobin level is part of the embryonic growth retardation
  • omphalocele (MGI Ref ID J:6184)
    • in a small number of embryos
  • growth/size phenotype
  • embryonic growth retardation (MGI Ref ID J:6184)
    • at embryonic day 11 mutants and wildtype can not be readily distinguished by growth retardation, but at embryonic day 12 mutants are clearly smaller and an approximately 1 day delay in development persists and is evident in reduced fetal weight and placental weight
    • although the total hemoglobin content is lower in age matched mutant and wildtype embryos the ratio of hemoglobin content to embryo weight is normal indicating that the diminished hemoglobin level is part of the embryonic growth retardation
  • craniofacial phenotype
  • anencephaly (MGI Ref ID J:6184)
    • in a small number of embryos
  • nervous system phenotype
  • anencephaly (MGI Ref ID J:6184)
    • in a small number of embryos
  • skeleton phenotype
  • anencephaly (MGI Ref ID J:6184)
    • in a small number of embryos
  • limbs/digits/tail phenotype
  • short tail (MGI Ref ID J:6184)
    • as early as embryonic day 11
  • hematopoietic system phenotype
  • *normal* hematopoietic system phenotype (MGI Ref ID J:6184)
    • the changes in the three hemoglobins expressed during fetal development from embryonic day 10 to 15 are normal
    • abnormal embryonic erythropoiesis (MGI Ref ID J:6184)
      • embryonic day 12-14 primitive nucleated erythrocytes have less hemoglobin content per cell than normal
      • embryonic day 11-13 primitive nucleated erythrocytes have increased mitotic indices
      • embryonic day 13 only 7% of the circulating cells are small non-nucleated erythrocytes compared with one third of the circulating cells in wildtype controls
      • delayed fetal hepatic erythropoiesis wherein embyronic day 12 mutants have primarily immature erythroid precursors and wildtype controls have many immature and mature erythroblasts

The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.

Ts/Ts

        BALB/c-Ts
  • lethality-prenatal/perinatal
  • embryonic lethality (MGI Ref ID J:13063)
    • embryonic lethality before implantation (MGI Ref ID J:6315)
      • at embryonic day 4.5 of heterozygous intercrosses there are fewer than the Mendelian expected 25% abnormal, presumed homozygous, embryos and the litter size is reduced suggesting the loss of some homozygotes between embryonic days 3.5 and 4.5
      • the number of implantations at 7 and 8 days of pregnancy in heterozygous intercrosses is a quarter less than normal indicating that homozygotes die before implantation or soon afterwards
  • cellular phenotype
  • abnormal nucleolus morphology (MGI Ref ID J:6315)
    • in embryonic day 3.5 presumed homozygous embryos nucleoli appear very ragged in outline and irregularly distribted in th nucleoplasm
  • decreased cell number (MGI Ref ID J:6315)
    • retarded cell dividion begins after the third cleavage such that there are only half the normal number of cells on embryonic day 3.5 and 20% the normal number on embryonic day 4.5
  • embryogenesis phenotype
  • abnormal blastocyst morphology (MGI Ref ID J:6315)
    • abnormal blastocoele morphology (MGI Ref ID J:6315)
      • failure to form blastocele (MGI Ref ID J:6315)
        • at embryonic day 3.5 presumed homozygotes have not formed a blastocoele
  • embryonic growth arrest (MGI Ref ID J:6315)
    • at embryonic day 3.5 there are approximately 13.7 cells per embryo instead of the normal 30.3, haematoxylin staining is much more pale, and the nucleoli often appear ragged in outline and irregularly ditributed throughout the nucleoplasm
    • at embryonic day 4.5 presumed homozygotes are retarded in developmental stage and cell number such that there is no clear delineation into inner cell mass and trophoblast, and these presumed homozygotes do not show signs of invasiveness when littermates are undergoing uterine attachment
    • at embryonic day 5.5 there are very few abnormal embryos compared with earlier timepoints and these are in various stages of degeneration
    • embryonic culture beginning at approximately day 3.5 confirms the in vivo findings
  • embryonic growth retardation (MGI Ref ID J:6315)
  • reduced embryo size (MGI Ref ID J:6315)
    • due to reduced number of embryonic cells
  • growth/size phenotype
  • embryonic growth retardation (MGI Ref ID J:6315)
  • reduced embryo size (MGI Ref ID J:6315)
    • due to reduced number of embryonic cells

Ts/Ts+

        BALB/c-Ts
  • craniofacial phenotype
  • increased skull width (MGI Ref ID J:15012)
    • greater width of the frontal bones
  • longitudinally short skull (MGI Ref ID J:15012)
    • in the short-snouted heterozygotes
  • short snout (MGI Ref ID J:15012)
    • in the most severely affected
  • growth/size phenotype
  • decreased body size (MGI Ref ID J:15012)
    • evident as early as embryonic day 9
    • decreased body length (MGI Ref ID J:13063)
      • slightly shortened body length of 85-95 mm versus 101 mm wildtype
    • decreased body weight (MGI Ref ID J:15012)
      • mutants weigh considerably less at birth and this persists throughout life
  • embryonic growth retardation (MGI Ref ID J:15012)
    • by embryonic day 14 there is a developmental delay of approximately 1 day, but by embyronic day 17 this delay is decreased
  • lethality-prenatal/perinatal
  • perinatal lethality (MGI Ref ID J:15012)
    • normal segregation at embryonic day 17 from matings of heterozygote x wildtype, but less than Mendelian predicted ratio at birth
  • limbs/digits/tail phenotype
  • abnormal long bone morphology (MGI Ref ID J:15012)
    • the length of the left humerus is shorter and the length of the right tibia is shorter than normal resulting in lopsided leg length, and the radius and femur are also shortened in some instances
    • abnormal humerus morphology (MGI Ref ID J:15012)
      • short humerus (MGI Ref ID J:15012)
    • short femur (MGI Ref ID J:15012)
    • short radius (MGI Ref ID J:15012)
    • short tibia (MGI Ref ID J:15012)
  • abnormal metacarpal bone morphology (MGI Ref ID J:15012)
    • feet can have fusions, absence of bones, and extra phalanges
  • abnormal metatarsal bone morphology (MGI Ref ID J:15012)
  • abnormal paw/hand/foot morphology (MGI Ref ID J:13063)
    • in a few cases the front paw is shortened and turned inward resembling a flipper
  • caudal vertebral fusion (MGI Ref ID J:13063)
    • common in heterozygotes and take place at all angles
  • curly tail (MGI Ref ID J:15012)
  • decreased caudal vertebrae number (MGI Ref ID J:13063)
    • there are fewer caudal vertebrae than normal and these are smaller than normal
  • kinked tail (MGI Ref ID J:15012)
    • the tail is usually kinked and sometimes curled
    • varying number of flexures due to irregular fusion of the vertebrae
  • short tail (MGI Ref ID J:15012)
    • varied penetrance, tail ranges from a small stump to approximately seven-eighths normal length
    • variable tail length ranging from 8-45 mm versus 103 mm for wildtype, but no tailless mice found
  • small caudal vertebrae (MGI Ref ID J:15012)
  • embryogenesis phenotype
  • abnormal notochord morphology (MGI Ref ID J:15012)
    • although nornmal at embryonic day 9, at embryonic day 10 to 11 the neural tube and notochord change shape, thickness and position several times along the length of the tail and the last somite is closer than normal to the tail tip. The neural tube is not affected in the trunk region until embryonic day 12 to 13 when it is thinner and when there are significant irregularities of shape and position of the notochord and neural tube.
  • abnormal placental vasculature (MGI Ref ID J:15012)
  • abnormal vitelline vasculature (MGI Ref ID J:15012)
    • blood vessels are paler, thinner, fewer in the placenta and yolk sac
  • embryonic growth retardation (MGI Ref ID J:15012)
    • by embryonic day 14 there is a developmental delay of approximately 1 day, but by embyronic day 17 this delay is decreased
  • skeleton phenotype
  • abnormal long bone morphology (MGI Ref ID J:15012)
    • the length of the left humerus is shorter and the length of the right tibia is shorter than normal resulting in lopsided leg length, and the radius and femur are also shortened in some instances
    • abnormal humerus morphology (MGI Ref ID J:15012)
      • short humerus (MGI Ref ID J:15012)
    • short femur (MGI Ref ID J:15012)
    • short radius (MGI Ref ID J:15012)
    • short tibia (MGI Ref ID J:15012)
  • abnormal metacarpal bone morphology (MGI Ref ID J:15012)
    • feet can have fusions, absence of bones, and extra phalanges
  • abnormal metatarsal bone morphology (MGI Ref ID J:15012)
  • abnormal sacral vertebrae morphology (MGI Ref ID J:15012)
    • 4th sacral vertebrae often often has laterally directed transverse processes and well defined alae sacrales whereas normally the 4th sacral vertebrae has anteriorly directed transverse processes without well defined alae sacrales
  • abnormal sternebra morphology (MGI Ref ID J:15012)
    • an extra sternebra and sternebrae fusions are found in some heterozygotes and in some the fifth sternebra appears to have been formed from two separate elements
  • abnormal vertebrae development (MGI Ref ID J:15012)
    • gaps in the vertebral arch or centrum
  • decreased caudal vertebrae number (MGI Ref ID J:13063)
    • there are fewer caudal vertebrae than normal and these are smaller than normal
  • increased rib number (MGI Ref ID J:15012)
    • an additional pair of ribs is found along with the increase in thoracic vertebrae
  • increased skull width (MGI Ref ID J:15012)
    • greater width of the frontal bones
  • increased thoracic vertebrae number (MGI Ref ID J:15012)
    • heterozygotes usually have 14 instead of the usual 13 thoracic vertebrae
  • longitudinally short skull (MGI Ref ID J:15012)
    • in the short-snouted heterozygotes
  • rib fusion (MGI Ref ID J:15012)
  • small caudal vertebrae (MGI Ref ID J:15012)
  • vertebral fusion (MGI Ref ID J:15012)
    • the vertebrae most susceptible to fusion are cervical 3 and 4 and thoracic 9, 10, and 11
    • caudal vertebral fusion (MGI Ref ID J:13063)
      • common in heterozygotes and take place at all angles
  • hematopoietic system phenotype
  • anemia (MGI Ref ID J:15012)
    • anemia is reported from embryonic day 9, pronounced at embryonic day 14, but newborns are not anemic
  • cardiovascular system phenotype
  • abnormal heart development (MGI Ref ID J:15012)
    • at embryonic day 12 to 13 the atrium is abnormally large, the verntricle abnormally small, the walls of the ventricle are thin and the trabeculae poorly developed, but the heart is normal at embryonic day 17
  • respiratory system phenotype
  • abnormal nasal cavity morphology (MGI Ref ID J:15012)
    • nasals are short, malformed and usually fused to the frontals, and the nasal processes are greadly reduced and sometimes bent sideways
  • nervous system phenotype
  • abnormal neural tube morphology/development (MGI Ref ID J:15012)
    • although nornmal at embryonic day 9, at embryonic day 10 to 11 the neural tube and notochord change shape, thickness and position several times along the length of the tail and the last somite is closer than normal to the tail tip. The neural tube is not affected in the trunk region until embryonic day 12 to 13 when it is thinner and when there are significant irregularities of shape and position of the notochord and neural tube.
    • abnormal neuromere morphology (MGI Ref ID J:15012)
    • wavy neural tube (MGI Ref ID J:15012)
  • abnormal olfactory bulb morphology (MGI Ref ID J:15012)
    • the brain is shortened longitudinally especially the olfactory region

Ts/Ts+

        involves: BALB/c
  • embryogenesis phenotype
  • abnormal notochord morphology (MGI Ref ID J:803)
    • histology at embyronic day 9.5 shows many sections of the perinotochordal sheath are normal while nearby sections have varying degrees of disintegration of the notochordal sheath
    • lateral defelection of the notocord also confirmed at embryonic day 9.5

Ts/Ts+

        (TSJ/Le x C57BL/6JJcl)F1
  • limbs/digits/tail phenotype
  • short tail (MGI Ref ID J:47940)
    • the outcross to a C57BL/6J background resulted in a shorter average tail length than on the pure TSJ/Le background

Ts/Ts+

        (TSJ/Le x A/JSlc)F1
  • lethality-postnatal
  • postnatal lethality (MGI Ref ID J:47940)
    • the short tail phenotype is entirely missing from litters at wean age and litters are smaller than normal

Ts/Ts+

        (TSJ/Le x CBA/J)F1
  • lethality-postnatal
  • postnatal lethality (MGI Ref ID J:47940)
    • the short tail phenotype is entirely missing from litters at wean age and litters are smaller than normal

Ts/Ts+

        (TSJ/Le x C3.SW-H2b/SnJ)F1
  • lethality-postnatal
  • postnatal lethality (MGI Ref ID J:47940)
    • the short tail phenotype is entirely missing from litters at wean age and litters are smaller than normal

Ts/Ts+

        (TSJ/Le x AKR/J)F1
  • lethality-postnatal
  • postnatal lethality (MGI Ref ID J:47940)
    • the short tail phenotype is entirely missing from litters at wean age and litters are smaller than normal

Ts/Ts+

        (BALB/c x C3H)F1
  • limbs/digits/tail phenotype
  • abnormal digit morphology (MGI Ref ID J:13063)
    • frequency is approximately 80% on the left forefoot, 10-15% on the right forefoot, and less than 10% on the hindfeet
    • oligodactyly (MGI Ref ID J:13063)
    • polydactyly (MGI Ref ID J:13063)
      • more common than oligodactyly and nearly always present in tailless heterozygotes
  • abnormal forelimb morphology (MGI Ref ID J:13063)
    • on occassion foreleg shortened and turned mediad such that it resembles a flipper
  • absent caudal vertebrae (MGI Ref ID J:13063)
  • absent tail (MGI Ref ID J:13063)
    • none of the (BALB/c x C3H)F1 mice have tails, far more severe than the short tail phenotype of the BALB/c background
  • growth/size phenotype
  • decreased body length (MGI Ref ID J:13063)
    • shorter than heterozygotes on the BALB/c background and only approximnately two-thirds the body length of wildtype F1 controls
  • lethality-prenatal/perinatal
  • perinatal lethality (MGI Ref ID J:13063)
    • half of the tailless mutants are born dead and some of these are almost devoid of blood and sometimes lack vescera
  • skeleton phenotype
  • abnormal nasal bone morphology (MGI Ref ID J:13063)
    • non-fusion of the nasals at the anterior end of the skull is often found
  • absent caudal vertebrae (MGI Ref ID J:13063)
  • increased skull width (MGI Ref ID J:13063)
    • in all of the tailless subset
  • longitudinally short skull (MGI Ref ID J:13063)
    • in all of the tailless subset
  • reproductive system phenotype
  • reduced fertility (MGI Ref ID J:13063)
    • none of the 4 surviving tailless heterozygotes bred; the one surviving female tailless heterozygote birthed one litter of 3 pups then died
  • hematopoietic system phenotype
  • anemia (MGI Ref ID J:13063)
  • nervous system phenotype
  • incomplete cephalic closure (MGI Ref ID J:13063)
    • some of the tailless subset are found to have spina bifida and even a dorsal cephalic opening due to failure of cranial fusion over the brain
  • spina bifida (MGI Ref ID J:13063)
    • in some of the tailless subset
  • pigmentation phenotype
  • belly spot (MGI Ref ID J:13063)
  • irregular coat pigmentation (MGI Ref ID J:13063)
    • tailless subset of mutants have white hairs on the front legs that looks like white stockings
  • skin/coat/nails phenotype
  • belly spot (MGI Ref ID J:13063)
  • irregular coat pigmentation (MGI Ref ID J:13063)
    • tailless subset of mutants have white hairs on the front legs that looks like white stockings
  • craniofacial phenotype
  • abnormal nasal bone morphology (MGI Ref ID J:13063)
    • non-fusion of the nasals at the anterior end of the skull is often found
  • increased skull width (MGI Ref ID J:13063)
    • in all of the tailless subset
  • longitudinally short skull (MGI Ref ID J:13063)
    • in all of the tailless subset

Ts/Ts+

        (BALB/c x A)F1
  • lethality-prenatal/perinatal
  • embryonic lethality (MGI Ref ID J:13063)
    • no mutant offspring were found in this cross and litters average 3.53 pups instead of 7.74, so tail short is believed to be a complete heterozygous lethal when crossed to the A inbred background

Ts/Ts+

        (BALB/c x DBA)F1
  • lethality-prenatal/perinatal
  • embryonic lethality (MGI Ref ID J:13063)
    • very small litter size of 2.94 pups per litter
  • limbs/digits/tail phenotype
  • absent tail (MGI Ref ID J:13063)
    • no short tailed mice are generated, only a small number of tailless mice indicating a more severe expressivity with the DBA background

Ts/Ts+

        (BALB/c x L)F1
  • limbs/digits/tail phenotype
  • short tail (MGI Ref ID J:13063)
    • the phenotype is similar to that found in pure BALB/c

Ts/Ts+

        (BALB/c x Y)F1
  • limbs/digits/tail phenotype
  • short tail (MGI Ref ID J:13063)
    • the phenotype is similar to that found on the pure BALB/c background regardless of the presence or absence of lethal yellow

Ts/Ts+

        (BALB/c x I)F1
  • limbs/digits/tail phenotype
  • short tail (MGI Ref ID J:13063)
    • the phenotype is similar to that found in pure BALB/c

Ts/Ts+

        (BALB/c x C57BR)F1
  • limbs/digits/tail phenotype
  • short tail (MGI Ref ID J:13063)
    • this hybrid background yields a slightly milder phenotype such that most mutants have a phenotype similar to that on the pure BALB/c background, but a few have tails longer than one-half normal length

Ts/Ts+

        (BALB/c x C57BL)F1
  • limbs/digits/tail phenotype
  • short tail (MGI Ref ID J:13063)
    • this hybrid background yields a very mild phenotype such that more than half of the mutants are have a normal body length at birth and they have a less kinked, longer tail than the mutants do on the pure BALB/c background

Gene & Allele Details

Allele Symbol Ts
Allele Name tail-short
Common Name(s) T-s;
Strain of OriginBALB/c
General Note Homozygotes are detectable at 3.5 days post-coitum as retarded pale-staining morulae; all are dead by 5.5 days. They also fail to develop in culture (J:6315). Viability and expression of heterozygotes is strongly dependent on the genetic background (J:13063). Recognizable by their shortened kinked tails, they are smaller than normal and have numerous skeletal abnormalities including vertebral fusions and dyssymphyses, bilateral asymmetry of the length of the humerus and tibia, triphalangy of digit 1 ofthe forefoot, an extra pair of ribs, and often a shortened and highly abnormal skull (J:15012). Embryonic studies of heterozygotes revealed disintegration of the notochord, basement membrane, and perinotochordal sheath as early as 9-1/2 days of gestation (J:803). There is a prenatal anemia at 13 to 17 days which disappears before birth (J:803). It is probably due to a general retardation of development rather than to a specific defect in erythropoiesis (J:6184). Because human campomelic dysplasia, which has some phenotypic resemblance to the mouse Ts syndrome (J:34432), is associated with mutations in the human SOX9 gene homologous to Sox9 (J:22021), it was suggested that Ts might represent a mutation in Sox9 . Expression of Sox9 during chondrogenesis in the mouse embryo (J:22300), and the coincident location of the two genes on Chr 11 (J:13797, J:22300), strengthened the suggestion. However, recombination between the two loci was found in an inbred strain cross (J:31828) and an intersubspecific cross (J:34432).
 
Allele Symbol Tyrp1b
Allele Name brown
Strain of OriginC57BL
Gene Symbol and Name Tyrp1, tyrosinase-related protein 1
Chromosome 4
Gene Common Name(s) B; CAS2; CATB; GP75; TRP; TRP-1; TRP1; TYRP; Tyrp; b; b-PROTEIN; brown; iris stromal atrophy; isa; tyrosinase-related protein;
General Note Tyrp1b, brown, recessive. This type mutant of the brown locus is an old mutation of the mouse fancy. The eumelanin of the hair and eyes is brown rather than black. The pigment granules also appear brown rather than black and are spheroid rather than ovoid in shape (J:12970). The fine structure of the developing pigment granules is fibrillar, like that of wild type mice, but the appearance of the mature granule may be more coarsely granular (J:5346, J:5001, J:5068). The granules incorporate twice as much 14C-tyrosine as normal (J:12173).
Molecular Note A G-to-A transition point mutation at position 329 was shown by revertant analysis to be responsible for the mutant phenotype seen in the brown mutant. This mutation is predicted to change a cysteine residue to a tyrosine in the encoded protein. Three other point mutations in the brown sequence were identified, but do not contribute to the mutant phenotype. [MGI Ref ID J:44435]

Control Information

  Allele   Control
 Ts  Wild-type from the colony
 
  Considerations for Choosing Controls

Related Strains

Strains carrying   Tyrp1b allele
000004   ABP/LeJ
000571   B6.Cg-Whrnwi Tyrp1b/+ +/J
000027   B6.D-Tyrp1b m/J
000670   DBA/1J
000265   MY/HuLeJ
001045   SI/Col Tyrp1b Dnahc11iv/J
000064   STOCK a Tyrp1b Sisi/J
002238   STOCK a Tyrp1b shmy/J
001432   STOCK a/a Tyrp1b sks/Tyrp1b +/J
000594   STOCK T(2;8)26H a/T(2;8)26H a Tyrp1+/Tyrp1b/J
001101   STOCK T(3;4)5Rk Tyrp1b/J
View Strains carrying   Tyrp1b     (11 strains)

Strains carrying other alleles of Tyrp1
000068   C57BL/6J-Tyrp1b-J/J
000093   C57BL/6J-Tyrp1b-cJ/J
000671   DBA/2J
003588   LT/SvEi
006252   LT/SvEiJ
002142   STOCK 11R30m/J
000594   STOCK T(2;8)26H a/T(2;8)26H a Tyrp1+/Tyrp1b/J
View Strains carrying other alleles of Tyrp1     (7 strains)

Animal Health Reports

Room Number           A1

Research Applications

This mouse can be used to support research in many areas including:

Ts related

Developmental Biology Research
Craniofacial and Palate Defects
Embryonic Lethality (Homozygous)
Growth Defects
Internal/Organ Defects (heart)
Internal/Organ Defects (vasculature)
Skeletal Defects

Hematological Research
Anemia, Iron Deficiency and Transport Defects

Tyrp1b related

Dermatology Research
Color and White Spotting Defects

Mouse/Human Gene Homologs
oculocutaneous albinism type III

References

Additional References

Price and Supply Information

Strain Name: TSJ/LeJ
Stock Number: 000274

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Supply Details

Standard SupplyRepository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of ~nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within 48 hours of order placement.
Supply Notes Usually shipped between four and eight weeks of age.
This strain is included in the Mouse Mutant Resource collection.
Genomic DNA is available for this strain from the Mouse DNA Resource.
LicensingSee General Terms and Conditions below  
Control InformationView Control Information in Strain Details.

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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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