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Strain Name:

STOCK gr +/+ Ap3d1mh/J

Stock Number:

000279

Availability:

Repository-Cryopreserved

Price and Supply Information

General Terms and Conditions

Former Name      STOCK gr +/+ Ap3dmh/J    (Changed: 15-DEC-04 )
Genes & Alleles   Ap3d1;   Ap3d1mh;   Pde6b;   Pde6brd1;   gr;

Product Information

Strain Details

Type JAX® GEMM® Strain - Mutant Stock
Additional information on JAX® GEMM® Strains.
Specieslaboratory mouse
GenerationF70

Appearance
agouti grey
Related Genotype: A/A gr +/gr ?

mocha coat color
Related Genotype: A/A Ap3d1mh +/Ap3d1mh ?

agouti
Related Genotype: A/A ? +/+ ? or A/A gr +/+ Ap3d1mh

Important Note
This strain is homozygous for the retinal degeneration allele Pde6brd1.

Strain Description
Mice homozygous for the mocha spontaneous mutation (Ap3d1mh) have increased perinatal mortality. They are recognizable at birth by the absence of visible pigment in the eyes, which darken to deep red in adults. The hairs have considerably smaller and fewer melanin granules than normal. Behavior is abnormal, characterized by hyperactivity, tilted heads, and in some the inability to swim. All homozygotes show degenerative changes in the organ of Corti, stria vascularis, and spiral ganglion, and most show abnormalities of the otoliths in the saccule and utricle. This degeneration can be lessened by the administration of supplemental manganese or, to a lesser degree, zinc to the dam during pregnancy. Evoked auditory brainstem responses appear normal in young homozygotes, but decrease with age coincident with the cochlear degeneration with no response detected after six months of age. At three months of age, mice homozygous for the Ap3d1mh allele have significantly increased auditory evoked potentials after the first of two paired tones. Ap3d1mh-2J homozygotes also show an increased response to thefirst tone but this has not been proven with statistical significance. Homozygotes also show prolonged bleeding times due to a platelet storage pool deficiency (SPD) associated with reduced granulation of the platelets. Consistent with this defective vesicle transport, homozygotes also have decreased levels of renal lysosomal enzymes in the urine. Mocha is thus a mouse mutation that, like pa (pallid) and mu (muted), offers a model for human Hermansky-Pudlak syndrome, combining pigment and otolith abnormalities with platelet SPD. Electrocorticograms from awake Ap3d1mh homozygotes show a constant, high voltage, bilaterally synchronous theta wave pattern that is diminished by chloral-hydrate anesthetization. Heterozygotes also have occasional brief bursts of lower voltage theta waves. Ap3d1mh-2J homozygotes do not display hypersynchronized electrocorticograms but have spike-wave and tonic clonic seizures. Ap3d1mh homozygotes may be fertile but are poor breeders. (Lane and Deol, 1974; Rolfson and Erway, 1984; Noebels and Sidman, 1989; Miller et al., 1999; Peden et al., 2002; Kantheti et al., 1998 and 2003.)

This strain is also segregating for the grizzled (gr) spontaneous mutation. gr is a recessive mutation that occasionally causes tail kinks and consistently causes dilution of the yellow pigment but not the black pigment of the hair. The coat color has been described as similar to chinchilla (Tyrc-ch/Tyrc-ch) but with the black pigment remaining undiluted. On the agouti JIGR/Dn background the gr/gr coat color is grayish agouti. On a non-agouti background the hair in the ears and around the genitalia is white. The gr mutation causes 40-50% mortality prior to phenotypic classification and this affects males more than females. This mortality is both postnatal and prenatal from approximately 10 days onward. Pregnant dams expected to carry some homozygotes have been found to carry some dead embryos some of which had craneofacial abnormalities including shortened snout and swollen optic and occipital regions. At birth homozygotes weigh an average of one quarter less than their wildtype siblings. Although they increase in weight as suckling pups, as adults they still weigh 5-25% less than their wildtype siblings. (Falconer, 1950; Bloom and Falconer, 1966.)

This strain is homozygous for the rd1 allele of Pde6b resulting in early onset retinal degeneration in all pups. (Lane and Deol, 1974; Qiao et al., 2003.)

Strain Development
The Ap3d1mh mutation arose spontaneously on the B6.C3-pi/+ background (then at N8) at The Jackson Laboratory in 1963 and was subsequently crossed to a variety of linkage testing stocks (including one carrying Ra, Os, and Pt, one carrying Kcnj6wv, one carrying Re, McolnVa, and Sd, and one carrying Gli3Xt-J, Lystbg-J, and Edaraddcr) before then being crossed to JIGR/Dn (then at F13) which carries ji and gr maintained in repulsion. ji was bred out and the resulting balanced stock with Ap3d1mh in repulsion with gr was then inbred via sibling mating. It reached F5 in 1972, F14 in 1975, F26 in 1978, F35 in 1980, F41 in 1982, F49 in 1984, and in 1989 doubly heterozygous (gr +/+ Ap3d1mh) females and males at F69 or F70 were sibling mated to generate embryos for freezing.

Related Disease (OMIM) Terms

Hermansky-Pudlak Syndrome; HPS
Mammalian Phenotype Terms assigned by genotype

Ap3d1mh gr+/Ap3d1+ gr

        STOCK gr +/+ Ap3d1mh/J
  • nervous system phenotype
  • abnormal brain wave pattern (MGI Ref ID J:96307)
    • electrocorticograms of mocha heterozygotes show occasional brief bursts of lower voltage theta waves, which are a less pronounced abnormality than in homozygotes

Ap3d1mh/Ap3d1mh

        STOCK gr +/+ Ap3d1mh/J
  • nervous system phenotype
  • abnormal nervous system physiology (MGI Ref ID J:94942)
    • synaptic zinc levels are reduced throughout the brain
    • abnormal brain wave pattern (MGI Ref ID J:96307)
      • electrocorticograms from most awake homozygotes show a constant, high voltage (300-600 microvolts), bilaterally synchronous theta wave pattern that is diminished by chloral-hydrate anesthetization
      • in some homozygotes there is unilateral hemispheric predominance of the altered theta frequency
      • sleep onset causes generalized slowing of cortical activity with sharp waves similar to normal controls
    • abnormal spike wave discharge (MGI Ref ID J:59842)
      • spike discharge episodes of .25-1 mV amplitude and approximately 0.5-2 seconds duration observed for 4 of 5 mocha homozygotes, more frequent than in mocha 2 Jackson homozygotes
    • enhanced sensorimotor gating (MGI Ref ID J:59842)
  • hearing/vestibular/ear phenotype
  • abnormal brainstem auditory evoked potential (MGI Ref ID J:59842)
    • the S1 response, but not the S2 response, is markedly greater than in controls and the auditory gating is significantly enhanced as a result
  • abnormal vestibule morphology (MGI Ref ID J:7485)
    • greatly reduced pigmentation within the vestibular portions of the inner ear, and this is not corrected by supplementing the mother's diet with manganese-zinc
    • absent otoliths (MGI Ref ID J:7485)
      • on a normal diet most mocha homozygotes lack otoconia in both the utricle and saccule of one or both ears, but this developmental defect can be greatly prevented in pups by supplementing the mother's diet with manganese-zinc
  • absent linear vestibular evoked potential (MGI Ref ID J:116914)
    • VESPs are absent at the maximum stimulus intensity used
  • lethality-postnatal
  • postnatal lethality (MGI Ref ID J:7485)
    • the percent homozygotes surviving to weaning is between 16% and 23% of Mendelian prediction, with some variation over time
    • the percent of newborn homozygotes is between 47% and 97% of Mendelian prediction, with many dying within the first two or three days after birth
  • behavior/neurological phenotype
  • abnormal spike wave discharge (MGI Ref ID J:59842)
    • spike discharge episodes of .25-1 mV amplitude and approximately 0.5-2 seconds duration observed for 4 of 5 mocha homozygotes, more frequent than in mocha 2 Jackson homozygotes
  • homeostasis/metabolism phenotype
  • abnormal platelet physiology (MGI Ref ID J:29151)
    • decreased aggregation both in the presence of high or low concentrations of collagen
    • decreased platelet serotonin level (MGI Ref ID J:29151)
      • platelet serotonin levels are less than 6% those of normal
  • increased bleeding time (MGI Ref ID J:29151)
    • bleed time is greater than 15 minutes
  • platelet storage pool deficiency (MGI Ref ID J:29151)
    • platelets nearly absent of dense granules
  • hematopoietic system phenotype
  • *normal* hematopoietic system phenotype (MGI Ref ID J:71349)
    • the invariant chain appears to mature and be degraded with normal kinetics, and to have a normal half-life in LPS stimulated antigen presenting cells,
    • MHC class II transport, peptide binding, and surface expression are normal
    • abnormal platelet dense granule morphology (MGI Ref ID J:29151)
      • although a normal number of dense granules stain with mepacrine, UV flashing is reduced by more than fivefold indicating an abnormal intragranular environment
      • abnormal platelet dense granule number (MGI Ref ID J:29151)
    • abnormal platelet physiology (MGI Ref ID J:29151)
      • decreased aggregation both in the presence of high or low concentrations of collagen
      • decreased platelet serotonin level (MGI Ref ID J:29151)
        • platelet serotonin levels are less than 6% those of normal
    • platelet storage pool deficiency (MGI Ref ID J:29151)
      • platelets nearly absent of dense granules
  • cellular phenotype
  • decreased lysosomal enzyme secretion (MGI Ref ID J:29151)
    • lysosomal enzyme levels are increased in kidneys and there is an associated decrease in secretion into the urine
    • thrombin-induced secretion of platelet lysosomal enzymes glucuronidase and galactosidase is only 30% to 45% of normal values and is not corrected by the addition of adenosine diphosphate
  • pigmentation phenotype
  • abnormal retinal pigment epithelium morphology (MGI Ref ID J:29151)
    • although homozygotes do not have the giant granules that are found in the retinal pigment epithelial cells of beige mice, they do have enlarged retinal pigment granules
  • vision/eye phenotype
  • abnormal retinal pigment epithelium morphology (MGI Ref ID J:29151)
    • although homozygotes do not have the giant granules that are found in the retinal pigment epithelial cells of beige mice, they do have enlarged retinal pigment granules
  • renal/urinary system phenotype
  • abnormal proximal convoluted tubule morphology (MGI Ref ID J:29151)
    • higher than normal autofluorescence, typical of ceroid-like pigment, is found in proximal tubules

The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.

Ap3d1mh/Ap3d1mh

        C57BL/6-pi
  • lethality-postnatal
  • postnatal lethality (MGI Ref ID J:5511)
    • 50-70% die between birth and 4 weeks of age depending on genetic background
  • pigmentation phenotype
  • diluted coat color (MGI Ref ID J:5511)
    • both yellow (phaeomelanin) and black (eumelanin) hairs are diluted
    • hairs in ear and around genitalia are white
  • reduced eye pigmentation (MGI Ref ID J:5511)
    • absence of visible eye pigment at birth
    • eyes of adult mice appear deep red
  • behavior/neurological phenotype
  • abnormal motor capabilities/coordination/movement (MGI Ref ID J:5511)
    • head tilt (MGI Ref ID J:5511)
      • all do not overtly display this but all show imbalance when handled
    • hyperactivity (MGI Ref ID J:5511)
      • contributes to poor breeding and offspring neglect
  • growth/size phenotype
  • postnatal growth retardation (MGI Ref ID J:5511)
    • at all ages mice are smaller than normal littermates
  • hearing/vestibular/ear phenotype
  • abnormal hearing physiology (MGI Ref ID J:5511)
    • mice are initially hypersensitive to sound
    • hearing loss progresses to complete deafness between 3-6 months of age
  • abnormal inner ear morphology (MGI Ref ID J:5511)
    • in surviving homozygous ranging 27 days or more
    • abnormal stria vascularis (MGI Ref ID J:5511)
      • almost always reduced
    • abnormal vestibule morphology (MGI Ref ID J:5511)
      • abnormal otolith morphology (MGI Ref ID J:89392)
        • inconsistent occurrence of variable amounts and distribution of crystals in some mutants
    • organ of Corti degeneration (MGI Ref ID J:5511)
      • >by 100 days of age there is extensive loss of hair cells and distortion of supporting cells
  • absent linear vestibular evoked potential (MGI Ref ID J:89392)
  • head tilt (MGI Ref ID J:5511)
    • all do not overtly display this but all show imbalance when handled
  • hematopoietic system phenotype
  • platelet storage pool deficiency (MGI Ref ID J:88018)
  • reproductive system phenotype
  • abnormal fertility/fecundity (MGI Ref ID J:5511)
    • hyperactivity contributes to poor breeding performance and offspring neglect
  • skin/coat/nails phenotype
  • diluted coat color (MGI Ref ID J:5511)
    • both yellow (phaeomelanin) and black (eumelanin) hairs are diluted
    • hairs in ear and around genitalia are white
  • vision/eye phenotype
  • reduced eye pigmentation (MGI Ref ID J:5511)
    • absence of visible eye pigment at birth
    • eyes of adult mice appear deep red
  • nervous system phenotype
  • cochlear ganglion degeneration (MGI Ref ID J:5511)
    • severe loss of cells in the spiral ganglion in animals over 100-days-old
  • homeostasis/metabolism phenotype
  • abnormal mineral level (MGI Ref ID J:50662)
    • loss of vesicular zinc
  • increased bleeding time (MGI Ref ID J:88018)
    • greater than 15 minutes compared to normal 2 minute bleeding time
  • platelet storage pool deficiency (MGI Ref ID J:88018)

gr/gr

        involves: A * STOCK fz
  • lethality-prenatal/perinatal
  • prenatal lethality (MGI Ref ID J:11987)
    • some survive to birth
    • cranial-facial defects commonly seen may contribute to mortality
  • lethality-postnatal
  • postnatal lethality (MGI Ref ID J:11987)
    • some mutants survive to maturity
    • more females than males survive
  • pigmentation phenotype
  • absent coat pigmentation (MGI Ref ID J:24769)
    • on a non-agouti background hairs on the ears and genitalia normally yellow are white
  • diluted coat color (MGI Ref ID J:11987)
    • dilutes yellow pigment (phaeomelanin)
    • agouti mice look like chinchilla (A/A;cch/cch)
  • growth/size phenotype
  • abnormal postnatal growth/weight/body size (MGI Ref ID J:11987)
    • abnormal body weight (MGI Ref ID J:11987)
      • weight is 25% less than normal at birth and remains 10-20% below weight of normal littermates
      • decreased body weight (MGI Ref ID J:11987)
        • weight data between 2 and 6 weeks of age show females are 75-80% of normal weight; males are 90-95% of normal weight
    • decreased body size (MGI Ref ID J:11987)
      • reduced body size
      • 20-30% smaller than normal littermates at birth
      • 10% smaller than normal littermates as adults
      • decreased body weight (MGI Ref ID J:11987)
        • weight data between 2 and 6 weeks of age show females are 75-80% of normal weight; males are 90-95% of normal weight
  • skin/coat/nails phenotype
  • absent coat pigmentation (MGI Ref ID J:24769)
    • on a non-agouti background hairs on the ears and genitalia normally yellow are white
  • diluted coat color (MGI Ref ID J:11987)
    • dilutes yellow pigment (phaeomelanin)
    • agouti mice look like chinchilla (A/A;cch/cch)
  • skeleton phenotype
  • abnormal skeleton morphology (MGI Ref ID J:11987)
    • abnormal craniofacial bone morphology (MGI Ref ID J:11987)
      • commom among E16-18 fetuses; not seen among pups after birth
      • abnormal skull morphology (MGI Ref ID J:11987)
        • abnormal jaw morphology (MGI Ref ID J:11987)
          • most frequent abnormaity among E16-18 fetuses; not seen among pups after birth
        • abnormal orbital bone morphology (MGI Ref ID J:11987)
          • frequently seen among E16-18 fetuses; not seen among pups after birth
  • craniofacial phenotype
  • abnormal craniofacial bone morphology (MGI Ref ID J:11987)
    • commom among E16-18 fetuses; not seen among pups after birth
    • abnormal skull morphology (MGI Ref ID J:11987)
      • abnormal jaw morphology (MGI Ref ID J:11987)
        • most frequent abnormaity among E16-18 fetuses; not seen among pups after birth
      • abnormal orbital bone morphology (MGI Ref ID J:11987)
        • frequently seen among E16-18 fetuses; not seen among pups after birth
  • reproductive system phenotype
  • abnormal ovulation (MGI Ref ID J:11987)
    • decreased ovulation frequency (MGI Ref ID J:11987)
      • although low compared to normal, ovulation rate is consistent with smaller size of mutant mice
  • limbs/digits/tail phenotype
  • abnormal tail morphology (MGI Ref ID J:11987)
    • kinked tail (MGI Ref ID J:11987)
      • occasionally seen
  • life span-post-weaning/aging
  • premature death (MGI Ref ID J:11987)
    • mortality occurs at all stages with loss of 50-60% of mutants

Gene & Allele Details

Allele Symbol Ap3d1mh
Allele Name mocha
Common Name(s) mh; mocha;
Strain of OriginC57BL/6-pi
Gene Symbol and Name Ap3d1, adaptor-related protein complex 3, delta 1 subunit
Chromosome 10
Gene Common Name(s) AA407035; ADTD; Ap3d; Bolvr; bovine leukemia virus receptor; expressed sequence AA407035; hBLVR; mBLVR1; mh; mocha;
Molecular Note The mutation is a 12 kb deletion that removes at least two exons, resulting in a 496 bp deletion of coding material shortly after the initiating ATG codon and causing an out of frame translation followed by a premature termination site. [MGI Ref ID J:50662]
 
Allele Symbol gr
Allele Name grizzled
Strain of OriginA x STOCK-Sgk3fz
Molecular Note This allele maps to a region of homology with the human paralemmin gene, PALM. Direct sequencing of RNA from brains of homozygous mice and analysis of the paralemmin coding region showed no sequence abnormalities. [MGI Ref ID J:47933]
 
Allele Symbol Pde6brd1
Allele Name retinal degeneration 1
Common Name(s) rd; rd-1; rd1; rodless retina;

Control Information

  Allele   Control
 Ap3d1mh  ? +/+ ? untested from colony
 gr  ? +/+ ? untested from colony
 
  Considerations for Choosing Controls
  Control Pricing Information for JAX® GEMM® Strains

Related Strains

Strains carrying   Pde6brd1 allele
004202   B6.C3 Pde6brd1 Hps4le/+ +-Lmx1adr-8J/J
000002   B6.C3-Pde6brd1 Hps4le/J
001022   B6C3FeF1/J a/a
000652   BDP/J
000653   BUB/BnJ
002439   C3.129P2(B6)-B2mtm1Unc/J
005494   C3.129S1(B6)-Grm1rcw/J
000480   C3.MRL-Faslpr/J
001957   C3A Pde6brd1.O20/A-Prph2Rd2/J
005973   C3Bir.129P2(B6)-Il10C3Bir/LtJ
004326   C3Bir.129P2(B6)-Il10tm1Cgn/Lt
003968   C3Bir.129P2(B6)-Il10tm1Cgn/LtJ
001906   C3Ga.Cg-Catb/J
001904   C3H-Atcayji-hes/J
000659   C3H/HeJ
000784   C3H/HeJ-Faslgld/J
000509   C3H/HeJ-Lystbg-2J/J
002433   C3H/HeJ-Spnb4qv-lnd2J/J
005972   C3H/HeJBirLtJ
001824   C3H/HeJSxJ
000635   C3H/HeOuJ
000474   C3H/HeSn
001431   C3H/HeSn-ocd/J
000661   C3H/HeSnJ
002235   C3H/HeSnJ-Ctnna2cdf/J
002333   C3H/HeSnJ-gri/J
006435   C3HeB.SW-Soaa/MonJ
000658   C3HeB/FeJ
001576   C3HeB/FeJ-Atp7btx-J/J
002588   C3HeB/FeJ-Eya1bor/J
001533   C3HeB/FeJ-Mc1rE-so Gli3Xt-J/J
001886   C3HeB/FeJLe a/a-gnd/J
001908   C3HfB/BiJ
001502   C3Sn.B6-Epha4rb/J
001547   C3Sn.Cg-Cm/J
000656   CBA/J
000813   CBA/J-Atp7aMo-pew/J
000660   DA/HuSnJ
000023   FL/1ReJ
000025   FL/4ReJ
003024   FVB.129P2(B6)-Fmr1tm1Cgr/J
002539   FVB.129P2-Abcb4tm1Bor/J
002935   FVB.129S2(B6)-Ccnd1tm1Wbg/J
002953   FVB.Cg-Tg(MMTVTGFA)254Rjc/J
003170   FVB.Cg-Tg(Myh6-tTA)6Smbf/J
003078   FVB.Cg-Tg(WapIgf1)39Dlr/J
003257   FVB/N-Tg(GFAPGFP)14Mes/J
002374   FVB/N-Tg(MMTV-PyVT)634Mul/J
002856   FVB/N-Tg(TIE2-lacZ)182Sato/J
002384   FVB/N-Tg(UcpDta)1Kz/J
001800   FVB/NJ
003487   FVB/NJ-Tg(XGFAP-lacZ)3Mes/J
001491   FVB/NMob
000734   MOLD/RkJ
000550   MOLF/EiJ
002423   NON/ShiLtJ
000679   P/J
000680   PL/J
100299   PLSJLF1/J
000269   SB/LeJ
005651   SJL.AK-Thy1a/TseJ
000686   SJL/J
000688   ST/bJ
004808   STOCK Mapttm1(EGFP)Klt Tg(MAPT)8cPdav/J
002648   STOCK a/a Cln6nclf/J
005965   STOCK Tg(Pomc1-cre)16Lowl/J
004770   SW.B6-Soab/J
002023   SWR.M-Emv21 Emv22/J
000689   SWR/J
000939   SWR/J-Clcn1adr-mto/J
000692   WB/ReJ KitW/J
100410   WBB6F1/J-KitW/KitW-v/J
000693   WC/ReJ KitlSl/J
100401   WCB6F1/J KitlSl KitlSl-d
View Strains carrying   Pde6brd1     (74 strains)

Strains carrying   gr allele
000572   JIGR/DnJ
View Strains carrying   gr     (1 strain)

View Strains carrying other alleles of Pde6b     (8 strains)

Research Applications

This mouse can be used to support research in many areas including:

Ap3d1mh related

Dermatology Research
Color and White Spotting Defects

Hematological Research
Platelet Defects (platelet storage pool deficiency)

Neurobiology Research
Epilepsy
Vestibular and Hearing Defects

Sensorineural Research
Vestibular and Hearing Defects

Pde6brd1 related

Mouse/Human Gene Homologs
retinitis pigmentosa, autosomal recessive

Sensorineural Research
Retinal Degeneration

gr related

Dermatology Research
Color and White Spotting Defects

Developmental Biology Research
Craniofacial and Palate Defects
Growth Defects
Perinatal Lethality (Homozygous)
Postnatal Mortality

References

Additional References

Price and Supply Information

Strain Name: STOCK gr +/+ Ap3d1mh/J
Stock Number: 000279

Price Details

IMPORTANT NOTE: Prices are based on shipping destination. The shipping destinations are:

*Pricing for Shipping Destination selected:

        USA, Canada and Mexico

Price(s) in US dollars ($)
Cryorecovery Fee $1900.00

Supply Details

Standard SupplyRepository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information.
Supply Notes Cryorecovery of Strains Needing Progeny Testing.
The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two untested males and two untested females (two pairs) will be recovered, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the overall recovery time to approximately 25 weeks. However, all pups recovered will be sent.

Progeny testing is required to identify the genotype of mice of this strain, as a genotyping assay is not available. This type of testing involves breeding the recovered animals and assessing the phenotype of the offspring in order to identify animals carrying the mutation of interest. We can perform the progeny testing for you as a service or we can ship all recovered animals (at least two untested pairs) to you for progeny testing at your facility. If you perform the progeny testing, there is NO guarantee that a carrier will be identified. If we perform progeny testing as a service, additional breeding time will be required. In this case, when a male and female (one pair) are identified that carry the mutation, they and their offspring will be shipped. Delivery time for strains requiring progeny testing often exceeds 25 weeks and may take 12 months or more due to the difficulties in breeding some strains. The progeny testing cost is in addition to the recovery cost and is based on the number of boxes used and the time taken to produce the mice identified as carrying the mutation. Please note that identified pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Please contact Customer Service for more information on the cost of progeny testing for a strain: Tel: 1-800-422-6423 or 1-207-288-5845.

Cryorecovery to establish a Dedicated Supply for greater quantities of mice
One to two pairs will be recovered to establish a Dedicated Supply of mice. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 or 1-207-288-5845.
This strain is included in the Mouse Mutant Resource collection.
Genomic DNA is available for this strain from the Mouse DNA Resource.

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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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