Strain Name:

STOCK a/a Tmem79ma Flgft/J

Stock Number:

000281

Order this mouse

Availability:

Cryopreserved - Ready for recovery

Other products are available, see Purchasing Information for Cryopreserved Embryos

Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Former Names STOCK a/a ma Flgft/ma Flgft/J    (Changed: 18-JUL-11 )
STOCK a/a ma ft/ma ft/J    (Changed: 02-SEP-09 )
Type Mutant Stock; Spontaneous Mutation;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Specieslaboratory mouse

Related Strains

Strains carrying   Tmem79ma allele
000022   B6.CBACaGr-Tmem79ma/J
View Strains carrying   Tmem79ma     (1 strain)

Strains carrying   a allele
003879   B10;TFLe-a/a T Itpr3tf/+ Itpr3tf/J
001538   B6 x B6C3Sn a/A-T(1;9)27H/J
000916   B6 x B6C3Sn a/A-T(5;12)31H/J
000602   B6 x B6C3Sn a/A-T(8;16)17H/J
000618   B6 x FSB/GnEi a/a Ctslfs/J
000577   B6 x STOCK a Oca2p Hps5ru2 Ednrbs/J
000601   B6 x STOCK a/a T(7;18)50H/J
000592   B6 x STOCK T(2;4)13H a/J
014608   B6;129S1-a Kitlsl-24J/GrsrJ
000231   B6;C3Fe a/a-Csf1op/J
000785   B6;D2-a Ces1ce/EiJ
000604   B6C3 a/A-T(10;13)199H +/+ Lystbg-J/J or Lystbg-2J/J
001750   B6C3Fe a/a-Eif3cXs-J/J
002807   B6C3Fe a/a-Meox2fla/J
000506   B6C3Fe a/a-Qkqk-v/J
000224   B6C3Fe a/a-Scyl1mdf/J
003020   B6C3Fe a/a-Zdhhc21dep/J
001037   B6C3Fe a/a-Agtpbp1pcd/J
000221   B6C3Fe a/a-Alx4lst-J/J
002062   B6C3Fe a/a-Atp7aMo-8J/J
001756   B6C3Fe a/a-Cacng2stg/J
001815   B6C3Fe a/a-Col1a2oim/J
000209   B6C3Fe a/a-Dh/J
000211   B6C3Fe a/a-Dstdt-J/J
000210   B6C3Fe a/a-Edardl-J/J
000207   B6C3Fe a/a-Edaraddcr/J
000182   B6C3Fe a/a-Eef1a2wst/J
001278   B6C3Fe a/a-Glra1spd/J
000241   B6C3Fe a/a-Glrbspa/J
002875   B6C3Fe a/a-Hoxd13spdh/J
000304   B6C3Fe a/a-Krt71Ca Scn8amed-J/J
000226   B6C3Fe a/a-Largemyd/J
000636   B6C3Fe a/a-Lmx1adr-J/J
001280   B6C3Fe a/a-Lse/J
001573   B6C3Fe a/a-MitfMi/J
001035   B6C3Fe a/a-Napahyh/J
000181   B6C3Fe a/a-Otogtwt/J
000278   B6C3Fe a/a-Papss2bm Hps1ep Hps6ru/J
000205   B6C3Fe a/a-Papss2bm/J
002078   B6C3Fe a/a-Pcdh15av-2J/J
000246   B6C3Fe a/a-Pitpnavb/J
001430   B6C3Fe a/a-Ptch1mes/J
000235   B6C3Fe a/a-Relnrl/J
000237   B6C3Fe a/a-Rorasg/J
000290   B6C3Fe a/a-Sox10Dom/J
000230   B6C3Fe a/a-Tcirg1oc/J
003612   B6C3Fe a/a-Trak1hyrt/J
001512   B6C3Fe a/a-Ttnmdm/J
001607   B6C3Fe a/a-Unc5crcm/J
000005   B6C3Fe a/a-Wc/J
000243   B6C3Fe a/a-Wnt1sw/J
000248   B6C3Fe a/a-Xpl/J
000624   B6C3Fe a/a-anx/J
008044   B6C3Fe a/a-bpck/J
002018   B6C3Fe a/a-din/J
002339   B6C3Fe a/a-nma/J
000240   B6C3Fe a/a-soc/J
000063   B6C3Fe a/a-sy/J
001055   B6C3Fe a/a-tip/J
000245   B6C3Fe a/a-tn/J
000296   B6C3Fe-a/a Hoxa13Hd Mcoln3Va-J/J
000019   B6C3Fe-a/a-Itpr1opt/J
001022   B6C3FeF1/J a/a
006450   B6EiC3 a/A-Vss/GrsrJ
000971   B6EiC3 a/A-Och/J
000551   B6EiC3 a/A-Tbx15de-H/J
000557   B6EiC3-+ a/LnpUl A/J
000503   B6EiC3Sn a/A-Gy/J
001811   B6EiC3Sn a/A-Otcspf-ash/J
002343   B6EiC3Sn a/A-Otcspf/J
000391   B6EiC3Sn a/A-Pax6Sey-Dey/J
001923   B6EiC3Sn a/A-Ts(417)2Lws TimT(4;17)3Lws/J
000225   C3FeLe.B6 a/a-Ptpn6me/J
000198   C3FeLe.B6-a/J
000291   C3FeLe.Cg-a/a Hm KitlSl Krt71Ca-J/J
001886   C3HeB/FeJLe a/a-gnd/J
000584   C57BL/6J-+ T(1;2)5Ca/a +/J
000670   DBA/1J
000671   DBA/2J
001057   HPT/LeJ
000260   JGBF/LeJ
000265   MY/HuLeJ
000308   SSL/LeJ
000994   STOCK a Myo5ad Mregdsu/J
000064   STOCK a Tyrp1b Pmelsi/J
002238   STOCK a Tyrp1b shmy/J
001433   STOCK a skt/J
000579   STOCK a tp/J
000319   STOCK a us/J
002648   STOCK a/a Cln6nclf/J
000317   STOCK a/a Egfrwa2/J
000302   STOCK a/a MitfMi-wh +/+ Itpr1opt/J
000286   STOCK a/a Myo5ad fd/+ +/J
000206   STOCK a/a Tyrc-h/J
001432   STOCK a/a Tyrp1b Ndc1sks/Tyrp1b +/J
000312   STOCK stb + a/+ Fignfi a/J
000596   STOCK T(2;11)30H/+ x AEJ-a Gdf5bp-H/J or A/J-a Gdf5bp-J/J
000970   STOCK T(2;16)28H A/T(2;16)28H a/J
000590   STOCK T(2;4)1Sn a/J
000594   STOCK T(2;8)26H a/T(2;8)26H a Tyrp1+/Tyrp1b/J
000623   TR/DiEiJ
View Strains carrying   a     (101 strains)

Strains carrying other alleles of Tmem79
014103   129;FVB-Tmem79m1J/GrsrJ
View Strains carrying other alleles of Tmem79     (1 strain)

Strains carrying other alleles of a
002655   Mus pahari/EiJ
000251   AEJ.Cg-ae +/a Gdf5bp-H/J
000202   AEJ/Gn-bd/J
000199   AEJ/GnLeJ
000433   B10.C-H3c H13? A/(28NX)SnJ
000427   B10.CE-H13b Aw/(30NX)SnJ
000423   B10.KR-H13? A/SnJ
000420   B10.LP-H13b Aw/Sn
000477   B10.PA-Bloc1s6pa H3e at/SnJ
000419   B10.UW-H3b we Pax1un at/SnJ
000593   B6 x B6CBCa Aw-J/A-Grid2Lc T(2;6)7Ca MitfMi-wh/J
000502   B6 x B6CBCa Aw-J/A-Myo5aflr Gnb5flr/J
000599   B6 x B6CBCa Aw-J/A-T(5;13)264Ca KitW-v/J
002083   B6 x B6EiC3 a/A-T(7;16)235Dn/J
000507   B6 x B6EiC3 a/A-Otcspf/J
003759   B6 x B6EiC3Sn a/A-T(10;16)232Dn/J
002071   B6 x B6EiC3Sn a/A-T(11;17)202Dn/J
002113   B6 x B6EiC3Sn a/A-T(11A2;16B3)238Dn/J
002068   B6 x B6EiC3Sn a/A-T(11B1;16B5)233Dn/J
002069   B6 x B6EiC3Sn a/A-T(14E4or5;16B5)225Dn/J
001926   B6 x B6EiC3Sn a/A-T(15;16)198Dn/J
001832   B6 x B6EiC3Sn a/A-T(15E;16B1)60Dn/J
003758   B6 x B6EiC3Sn a/A-T(16C3-4;17A2)65Dn/J
001833   B6 x B6EiC3Sn a/A-T(1C2;16C3)45Dn/J
001903   B6 x B6EiC3Sn a/A-T(6F;18C)57Dn/J
001535   B6 x B6EiC3Sn a/A-T(8A4;12D1)69Dn/J
001831   B6 x B6EiC3Sn a/A-T(8C3;16B5)164Dn/J
002016   B6(Cg)-Aw-J EdaTa-6J Chr YB6-Sxr/EiJ
000600   B6-Gpi1b x B6CBCa Aw-J/A-T(7;15)9H Gpi1a/J
000769   B6.C/(HZ18)By-at-44J/J
000203   B6.C3-Aiy/a/J
000017   B6.C3-Avy/J
001572   B6.C3-am-J/J
000628   B6.CE-A Amy1b Amy2a5b/J
001809   B6.Cg-Aw-J EdaTa-6J +/+ ArTfm/J
000552   B6.Cg-Aw-J EdaTa-6J Sxr
001730   B6.Cg-Aw-J EdaTa-6J Sxrb Hya-/J
000841   B6.Cg-Aw-J EdaTa-By/J
000021   B6.Cg-Ay/J
100409   B6129PF1/J-Aw-J/Aw
004200   B6;CBACa Aw-J/A-Npr2cn-2J/GrsrJ
000505   B6C3 Aw-J/A-Bloc1s5mu/J
000604   B6C3 a/A-T(10;13)199H +/+ Lystbg-J/J or Lystbg-2J/J
000065   B6C3Fe a/a-we Pax1un at/J
003301   B6C3FeF1 a/A-Eya1bor/J
000314   B6CBACa Aw-J/A-EdaTa/J-XO
000501   B6CBACa Aw-J/A-Aifm1Hq/J
001046   B6CBACa Aw-J/A-Grid2Lc/J
000500   B6CBACa Aw-J/A-Gs/J
002703   B6CBACa Aw-J/A-Hydinhy3/J
000247   B6CBACa Aw-J/A-Kcnj6wv/J
000287   B6CBACa Aw-J/A-Plp1jp EdaTa/J
000515   B6CBACa Aw-J/A-SfnEr/J
000242   B6CBACa Aw-J/A-spc/J
000288   B6CBACa Aw-J/A-we a Mafbkr/J
001201   B6CBACaF1/J-Aw-J/A
006450   B6EiC3 a/A-Vss/GrsrJ
000557   B6EiC3-+ a/LnpUl A/J
000504   B6EiC3Sn a/A-Cacnb4lh/J
000553   B6EiC3Sn a/A-Egfrwa2 Wnt3avt/J
001811   B6EiC3Sn a/A-Otcspf-ash/J
002343   B6EiC3Sn a/A-Otcspf/J
001923   B6EiC3Sn a/A-Ts(417)2Lws TimT(4;17)3Lws/J
001875   B6EiC3SnF1/J
000638   C3FeB6 A/Aw-J-Sptbn4qv-J/J
000200   C3FeB6 A/Aw-J-Ankank/J
001203   C3FeB6F1/J A/Aw-J
001272   C3H/HeSnJ-Ahvy/J
000099   C3HeB/FeJ-Avy/J
000338   C57BL/6J Aw-J-EdaTa-6J/J
000258   C57BL/6J-Ai/a/J
000774   C57BL/6J-Asy/a/J
000569   C57BL/6J-Aw-J-EdaTa +/+ ArTfm/J
000051   C57BL/6J-Aw-J/J
000055   C57BL/6J-at-33J/J
000070   C57BL/6J-atd/J
002468   KK.Cg-Ay/J
000262   LS/LeJ
000283   LT.CAST-A/J
001759   STOCK A Tyrc Sha/J
001427   STOCK Aw us/J
001145   WSB/EiJ
View Strains carrying other alleles of a     (82 strains)

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- Model with phenotypic similarity to human disease where etiologies involve orthologs. Human genes are associated with this disease. Orthologs of those genes appear in the mouse genotype(s).
Dermatitis, Atopic, 2; ATOD2
Models with phenotypic similarity to human diseases where etiology is unknown or involving genes where ortholog is unknown.
Dermatitis, Atopic
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested.
Ichthyosis Vulgaris   (FLG)
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

Flgft/Flgft

        STOCK a/a Tmem79ma Flgft/J
  • integument phenotype
  • abnormal skin morphology
    • skin of 5 day old pups contains a higher population of langerin positive cells   (MGI Ref ID J:204304)
    • acanthosis
      • seen by 5 days of age   (MGI Ref ID J:204304)
    • epidermal spongiosis
      • mild spongiosis is seen by 5 days of age   (MGI Ref ID J:204304)
    • flaky skin
    • hyperkeratosis
      • mild hyperkeratosis is seen by 5 days of age   (MGI Ref ID J:204304)
    • scaly skin
      • presence of scales on the tail skin   (MGI Ref ID J:204304)
      • however mice do not exhibit abnormal corneodesmosomal desquamation   (MGI Ref ID J:204304)
    • thick epidermis
      • seen by 5 days of age   (MGI Ref ID J:204304)
    • thin epidermis stratum granulosum
      • hypogranulosis   (MGI Ref ID J:204304)
  • abnormal skin physiology
    • lymphocytic exocytosis in 5 day old skin   (MGI Ref ID J:204304)
    • marker analysis indicates abnormal differentiation state of the epidermis and hyperproliferation   (MGI Ref ID J:204304)
    • dermatitis
      • reactive inflammatory epidermitis by 5 days of age   (MGI Ref ID J:204304)
  • homeostasis/metabolism phenotype
  • abnormal cytokine level
    • skin of 5 day old pups shows increased levels of proinflammatory cytokines, including Il4, Il13, Il1beta, and Tslp   (MGI Ref ID J:204304)
  • epidermal spongiosis
    • mild spongiosis is seen by 5 days of age   (MGI Ref ID J:204304)
  • immune system phenotype
  • abnormal cytokine level
    • skin of 5 day old pups shows increased levels of proinflammatory cytokines, including Il4, Il13, Il1beta, and Tslp   (MGI Ref ID J:204304)
  • dermatitis
    • reactive inflammatory epidermitis by 5 days of age   (MGI Ref ID J:204304)

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

Flgft/Flgft

        involves: C57BL/6J
  • mortality/aging
  • postnatal lethality
    • death before weaning may be due to inability to compete for food due to small size   (MGI Ref ID J:5286)
  • growth/size/body phenotype
  • decreased body size
    • between 5 and 14 days of age most mutants are smaller than age and sex-matched sibs   (MGI Ref ID J:5286)
  • small ears
    • between 5 and 14 days of age ears are shorter and thicker than normal sibs   (MGI Ref ID J:5286)
    • small ears persist at 3 to 4 weeks of age but may be difficult to discern   (MGI Ref ID J:5286)
  • hearing/vestibular/ear phenotype
  • small ears
    • between 5 and 14 days of age ears are shorter and thicker than normal sibs   (MGI Ref ID J:5286)
    • small ears persist at 3 to 4 weeks of age but may be difficult to discern   (MGI Ref ID J:5286)
  • craniofacial phenotype
  • small ears
    • between 5 and 14 days of age ears are shorter and thicker than normal sibs   (MGI Ref ID J:5286)
    • small ears persist at 3 to 4 weeks of age but may be difficult to discern   (MGI Ref ID J:5286)
  • integument phenotype
  • abnormal epidermis stratum granulosum morphology
    • between 1 and 8 days of age the stratum granulosum does not contain as many layers as that of normal sibs   (MGI Ref ID J:5286)
  • abnormal skin appearance
    • as early as 2 to 4 days skin of feet appear stretched and skin on the back appears stretched and shiny   (MGI Ref ID J:5286)
    • fewer cells in this layer may reflect inactivity of underlying layers   (MGI Ref ID J:5286)
    • flaky skin
      • apparent at 2-4 days of age especially on the tail   (MGI Ref ID J:5286)
      • flaking ceases about 14 days of age but tails may develop constricted rings and become necrotic   (MGI Ref ID J:5286)
      • by 3 to 4 weeks of age if tail constriction has not progressed to amputation, mice look normal except for small ears   (MGI Ref ID J:5286)
      • this mutatation may provide insight into th molecular basis of filaggrin-deficient human ichthyosis vulgaris   (MGI Ref ID J:5286)
  • acanthosis   (MGI Ref ID J:66567)
  • hyperkeratosis
    • mice lack normal keratohyalin F granules and filaggrin implicated in epidermal hydration   (MGI Ref ID J:66567)

Flgft/Flgft

        involves: C57BL/6
  • immune system phenotype
  • skin inflammation
    • mice exhibit sporadic superficial dermal cellular infiltration that includes lymphocytes, eosinophils, and mononuclear cells   (MGI Ref ID J:151110)
  • integument phenotype
  • *normal* integument phenotype
    • transepidermal water loss is not statistically different from in wild-type mice in untreated mice   (MGI Ref ID J:151110)
    • acanthosis
      • the magnitude of acanthosis is variable among individual mice   (MGI Ref ID J:151110)
    • orthokeratosis
      • at 6 to 8 weeks of age   (MGI Ref ID J:151110)
    • skin inflammation
      • mice exhibit sporadic superficial dermal cellular infiltration that includes lymphocytes, eosinophils, and mononuclear cells   (MGI Ref ID J:151110)

Flgft/Flgft

        B6.Cg-Flgft
  • immune system phenotype
  • *normal* immune system phenotype
    • mice exhibit normal pulmonary sensitization and airway hyper-responsiveness following exposure to ovalbumin   (MGI Ref ID J:151110)
    • mice exhibit normal immune sensitization to intraperitoneal injections of ovalbumin   (MGI Ref ID J:151110)
    • dermatitis-like skin inflammation is not detected   (MGI Ref ID J:202453)
    • increased IgE level   (MGI Ref ID J:202453)
      • following cutaneous ovalbumin treatment   (MGI Ref ID J:151110)
    • increased IgG level
      • following cutaneous ovalbumin treatment   (MGI Ref ID J:151110)
      • increased IgG1 level
        • following cutaneous ovalbumin treatment   (MGI Ref ID J:151110)
      • increased IgG2a level
        • following cutaneous ovalbumin treatment   (MGI Ref ID J:151110)
    • increased interferon-gamma secretion
      • from splenocytes following cutaneous ovalbumin treatment   (MGI Ref ID J:151110)
    • increased interleukin-10 secretion
      • from splenocytes following cutaneous ovalbumin treatment   (MGI Ref ID J:151110)
    • increased interleukin-13 secretion
      • from splenocytes following cutaneous ovalbumin treatment   (MGI Ref ID J:151110)
    • increased interleukin-17 secretion
      • from splenocytes following cutaneous ovalbumin treatment   (MGI Ref ID J:151110)
    • increased interleukin-4 secretion
      • from splenocytes following cutaneous ovalbumin treatment   (MGI Ref ID J:151110)
    • increased interleukin-5 secretion
      • from splenocytes following cutaneous ovalbumin treatment   (MGI Ref ID J:151110)
    • increased splenocyte proliferation
      • following cutaneous ovalbumin treatment   (MGI Ref ID J:151110)
  • integument phenotype
  • abnormal epidermal layer morphology   (MGI Ref ID J:202453)
    • acanthosis
      • cutaneous exposure to ovalbumin induces mild acanthosis with infiltrates of mixed inflammatory cells unlike in similarly treated wild-type mice   (MGI Ref ID J:151110)
      • focal   (MGI Ref ID J:202453)
    • orthokeratosis
      • mild and diffuse, with increased dermal cell infiltration compared to controls   (MGI Ref ID J:202453)
  • abnormal hair cuticle
    • defective cuticle morphology   (MGI Ref ID J:202453)
  • dry skin
    • significant ichthyosis is seen in neonates   (MGI Ref ID J:202453)
  • impaired skin barrier function
    • cutaneous ovalbumin treatment results in greater transepidermal water loss than in similarly treated wild-type mice   (MGI Ref ID J:151110)
  • scaly skin
    • significant ichthyosis is seen in neonates   (MGI Ref ID J:202453)
  • hematopoietic system phenotype
  • increased IgE level   (MGI Ref ID J:202453)
    • following cutaneous ovalbumin treatment   (MGI Ref ID J:151110)
  • increased IgG level
    • following cutaneous ovalbumin treatment   (MGI Ref ID J:151110)
    • increased IgG1 level
      • following cutaneous ovalbumin treatment   (MGI Ref ID J:151110)
    • increased IgG2a level
      • following cutaneous ovalbumin treatment   (MGI Ref ID J:151110)
  • increased splenocyte proliferation
    • following cutaneous ovalbumin treatment   (MGI Ref ID J:151110)
  • homeostasis/metabolism phenotype
  • impaired skin barrier function
    • cutaneous ovalbumin treatment results in greater transepidermal water loss than in similarly treated wild-type mice   (MGI Ref ID J:151110)
  • cellular phenotype
  • increased splenocyte proliferation
    • following cutaneous ovalbumin treatment   (MGI Ref ID J:151110)

Flgft/Flgft

        Background Not Specified
  • integument phenotype
  • dermatitis
    • even in specific pathogen free conditions   (MGI Ref ID J:198332)
  • impaired skin barrier function   (MGI Ref ID J:192725)
    • increased transepidermal water loss   (MGI Ref ID J:198332)
  • homeostasis/metabolism phenotype
  • impaired skin barrier function   (MGI Ref ID J:192725)
    • increased transepidermal water loss   (MGI Ref ID J:198332)
  • immune system phenotype
  • dermatitis
    • even in specific pathogen free conditions   (MGI Ref ID J:198332)

Flgft/Flgft Tmem79ma/Tmem79ma

        involves: C57BL/6J * CBA/CaGr
  • integument phenotype
  • *normal* integument phenotype
    • mice were examined at 5 weeks of age when the effects of the flaky-skin mutation on skin condition are not yet seen   (MGI Ref ID J:30359)
    • abnormal coat/ hair morphology   (MGI Ref ID J:30359)
      • abnormal coat appearance
        • clumped hair and bald spots develop in mutant mice by 4 weeks of age   (MGI Ref ID J:30359)
        • the hair of older non-agouti black mice may appear brown although a pigment defect is not reported   (MGI Ref ID J:30359)
        • alopecia
          • bald patches occur in areas that are rubbed, breaking hair shafts   (MGI Ref ID J:30359)
        • matted coat
          • clumped hair can be seen in mutant mice by 4 weeks of age   (MGI Ref ID J:30359)
          • saliva introduced during grooming causes the hair to mat   (MGI Ref ID J:30359)
          • the matted appearance is easily seen when the fur is stroked opposite the normal direction of the coat   (MGI Ref ID J:30359)
      • abnormal hair shaft morphology
        • hair shaft above matrix does not develop normally in some mutant mice   (MGI Ref ID J:30359)
        • hairs tend to break and split   (MGI Ref ID J:30359)
    • abnormal hair follicle matrix region morphology
      • found where hair shafts become structurallly abnormal   (MGI Ref ID J:30359)

Tmem79ma/Tmem79ma

        involves: CBA/CaGr
  • integument phenotype
  • abnormal coat appearance   (MGI Ref ID J:24772)
    • alopecia
      • hairs break leading to variable degrees of baldness as mice age   (MGI Ref ID J:24772)
    • matted coat
      • the phenotype is obvious by 4 weeks of age, especially on the back and flanks where groups of hairs are matted at tips to form clumps   (MGI Ref ID J:24772)
      • hair does not lie flat   (MGI Ref ID J:24772)
  • abnormal hair cycle
    • there is no significant difference in the lengths of the first and second hair generations   (MGI Ref ID J:12995)
    • the third hair generation was shorter than normal and likely due to friction on skin exposed by progressive hair-loss   (MGI Ref ID J:12995)
  • abnormal hair shaft morphology   (MGI Ref ID J:12995)
    • abnormal hair cuticle
      • cuticle shown to be permeable using fluorescent markers   (MGI Ref ID J:12995)
      • abnormal distribution of S-S linkage structure inferred as causal from experiments on normal cuticle   (MGI Ref ID J:12995)

Tmem79ma/Tmem79ma

        involves: C57BL/Gr * CBA/CaGr
  • pigmentation phenotype
  • darkened coat color
    • the matted hair exposes the black basal part of agouti hair, making the coat appear russet rather than black however there is no affect on pigment other than that found in the normal ageing process in C57 black mice   (MGI Ref ID J:12996)
    • the timing of changes in the coat color indicates early ageing in mutant mice   (MGI Ref ID J:12996)
  • integument phenotype
  • abnormal coat appearance
    • areas of small clumps contribute to a rough appearance   (MGI Ref ID J:12996)
    • abnormal hair growth
      • hairs are brittle and tend to split longitudinally   (MGI Ref ID J:12996)
      • alopecia
        • belly and head are rarely affected   (MGI Ref ID J:12996)
        • there is variable loss over the back and flanks due to rubbing on environmental surfaces   (MGI Ref ID J:12996)
        • baldness results from breakage above the skin rather than from patchy hair loss or failure of hairto regrow after molting   (MGI Ref ID J:12996)
    • darkened coat color
      • the matted hair exposes the black basal part of agouti hair, making the coat appear russet rather than black however there is no affect on pigment other than that found in the normal ageing process in C57 black mice   (MGI Ref ID J:12996)
      • the timing of changes in the coat color indicates early ageing in mutant mice   (MGI Ref ID J:12996)
    • matted coat
      • largest clumps involve dorsal long hair where least density   (MGI Ref ID J:12996)
      • areas of small clumps contribute to a rough appearance   (MGI Ref ID J:12996)
      • clumping is an outcome of grooming, saliva adhering distal hair shafts   (MGI Ref ID J:12996)

Tmem79ma/Tmem79ma

        involves: C57BL/6JJcl * CBA/CaGr
  • integument phenotype
  • abnormal epidermis stratum corneum morphology
    • impaired formation wit less resistance to physical external stress in a tape stripping test   (MGI Ref ID J:202316)
  • acanthosis
    • with leukocyte infiltration at 1 week prior to scratching behavior   (MGI Ref ID J:202316)
  • dermatitis
    • spontaneous dermatitis with scratching behavior   (MGI Ref ID J:202316)
    • however, dermatitis is rescued by transgenic expression of the wild-type gene   (MGI Ref ID J:202316)
  • impaired skin barrier function
    • increased transepidermal water loss and lower stratum corneum hydration   (MGI Ref ID J:202316)
  • matted coat   (MGI Ref ID J:202316)
  • immune system phenotype
  • dermatitis
    • spontaneous dermatitis with scratching behavior   (MGI Ref ID J:202316)
    • however, dermatitis is rescued by transgenic expression of the wild-type gene   (MGI Ref ID J:202316)
  • behavior/neurological phenotype
  • excessive scratching
    • spontaneous dermatitis with scratching behavior   (MGI Ref ID J:202316)
  • homeostasis/metabolism phenotype
  • impaired skin barrier function
    • increased transepidermal water loss and lower stratum corneum hydration   (MGI Ref ID J:202316)

Tmem79ma/Tmem79ma

        B6.CBACaGr-Tmem79ma/J
  • integument phenotype
  • abnormal coat appearance   (MGI Ref ID J:202453)
    • alopecia
      • occasional at 32 weeks of age   (MGI Ref ID J:202453)
    • brittle hair
      • hair breakage at 32 weeks of age   (MGI Ref ID J:202453)
    • matted coat   (MGI Ref ID J:202453)
  • abnormal corneocyte envelope morphology
    • cornified cell envelopes are discontinuous, uneven, and highly disorganized   (MGI Ref ID J:202453)
  • abnormal hair cortex keratinization
    • keratinization defects   (MGI Ref ID J:202453)
  • abnormal hair follicle development
    • distorted hair follicle morphogenesis   (MGI Ref ID J:202453)
  • acanthosis
  • impaired skin barrier function
    • increased transepidermal water loss   (MGI Ref ID J:202453)
  • orthokeratosis
    • prominent, with dermal inflammatory infiltrates   (MGI Ref ID J:202453)
  • skin inflammation
    • marked skin inflammation with a broad spectrum of pathologies   (MGI Ref ID J:202453)
    • some mice exhibit profound lesions and excoriation   (MGI Ref ID J:202453)
    • skin inflammation following treatment with house dust might allergen is enhanced   (MGI Ref ID J:202453)
    • dermatitis
      • spontaneous, progressive dermatitis-like skin inflammation   (MGI Ref ID J:202453)
      • spontaneous atopic dermatitis   (MGI Ref ID J:202453)
  • immune system phenotype
  • blepharitis
    • occasional blepharitis and eyelid dermatitis in some mice   (MGI Ref ID J:202453)
  • increased IgE level   (MGI Ref ID J:202453)
  • skin inflammation
    • marked skin inflammation with a broad spectrum of pathologies   (MGI Ref ID J:202453)
    • some mice exhibit profound lesions and excoriation   (MGI Ref ID J:202453)
    • skin inflammation following treatment with house dust might allergen is enhanced   (MGI Ref ID J:202453)
    • dermatitis
      • spontaneous, progressive dermatitis-like skin inflammation   (MGI Ref ID J:202453)
      • spontaneous atopic dermatitis   (MGI Ref ID J:202453)
  • vision/eye phenotype
  • blepharitis
    • occasional blepharitis and eyelid dermatitis in some mice   (MGI Ref ID J:202453)
  • hematopoietic system phenotype
  • increased IgE level   (MGI Ref ID J:202453)
  • homeostasis/metabolism phenotype
  • impaired skin barrier function
    • increased transepidermal water loss   (MGI Ref ID J:202453)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Flgft related

Dermatology Research
Skin and Hair Texture Defects

Tmem79ma related

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Flgft
Allele Name flaky tail
Allele Type Spontaneous
Common Name(s) FlgdelAPfal; ft/ma;
Gene Symbol and Name Flg, filaggrin
Chromosome 3
Gene Common Name(s) AW107830; expressed sequence AW107830; fillagrin; flaky tail; ft; profilaggrin;
Molecular Note A single nucleotide deletion at position 5303 in exon 3 (5303delA) results in a frameshift mutation and premature truncation of the predicted protein product. The copy number of the filaggrin repeat contained within this gene vary depending on the background strain. While this mutant occurs in an allele with 16 copies of the filaggrin repeat, the wild-type C57BL/6 allele contains 17 copies of the repeat. This indicates that the ft mutation arose on a C3H allele. Excluding the repeat copy number variation, this allele is 99.3% identical to the C57BL/6 wild-type allele. Reduced expression of the truncated protein was confirmed by western blot analysis on mouse skin extracts. [MGI Ref ID J:151110]
 
Allele Symbol Tmem79ma
Allele Name matted
Allele Type Spontaneous
Common Name(s) ma; matted;
Strain of OriginCBA/CaGr
Gene Symbol and Name Tmem79, transmembrane protein 79
Chromosome 3
Gene Common Name(s) 2310042N02Rik; 2310074C17Rik; MATT; RGD1309886; RIKEN cDNA 2310042N02 gene; RIKEN cDNA 2310074C17 gene; ma; matted; mattrin;
Molecular Note A spontaneous C to G nonsense mutation that results in the substitution of a stop for a tyrosine at position 280 (Y280X). [MGI Ref ID J:202316] [MGI Ref ID J:202453]
 
Allele Symbol a
Allele Name nonagouti
Allele Type Spontaneous
Strain of Originold mutant of the mouse fancy
Gene Symbol and Name a, nonagouti
Chromosome 2
Gene Common Name(s) AGSW; AGTI; AGTIL; ASP; As; SHEP9; agouti; agouti signal protein; agouti suppressor;
General Note Phenotypic Similarity to Human Syndrome: Metabolic Syndrome in mice homozygous for Apoetm1Unc and heterozygous for Ay and a (J:177084)
Molecular Note Characterization of this allele shows an insertion of DNA comprised of a 5.5kb virus-like element, VL30, into the first intron of the agouti gene. The VL30 element itself contains an additional 5.5 kb sequence, flanked by 526 bp of direct repeats. The host integration site is the same as for at-2Gso and Aw-38J and includes a duplication of four nucleotides of host DNA and a deletion of 2 bp from the end of each repeat. Northern analysis of mRNA from skin of homozygotes shows a smaller agouti message and levels 8 fold lower than found in wild-type. [MGI Ref ID J:16984] [MGI Ref ID J:24934]

Genotyping

Genotyping Information


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Additional References

Presland RB; Boggess D; Lewis SP; Hull C; Fleckman P; Sundberg JP. 2000. Loss of normal profilaggrin and filaggrin in flaky tail (ft/ft) mice: an animal model for the filaggrin-deficient skin disease ichthyosis vulgaris. J Invest Dermatol 115(6):1072-81. [PubMed: 11121144]  [MGI Ref ID J:66567]

Flgft related

Fallon PG; Sasaki T; Sandilands A; Campbell LE; Saunders SP; Mangan NE; Callanan JJ; Kawasaki H; Shiohama A; Kubo A; Sundberg JP; Presland RB; Fleckman P; Shimizu N; Kudoh J; Irvine AD; Amagai M; McLean WH. 2009. A homozygous frameshift mutation in the mouse Flg gene facilitates enhanced percutaneous allergen priming. Nat Genet 41(5):602-8. [PubMed: 19349982]  [MGI Ref ID J:151110]

Kawasaki H; Nagao K; Kubo A; Hata T; Shimizu A; Mizuno H; Yamada T; Amagai M. 2012. Altered stratum corneum barrier and enhanced percutaneous immune responses in filaggrin-null mice. J Allergy Clin Immunol 129(6):1538-46.e6. [PubMed: 22409988]  [MGI Ref ID J:198332]

Kypriotou M; Boechat C; Huber M; Hohl D. 2013. Spontaneous atopic dermatitis-like symptoms in a/a ma ft/ma ft/J flaky tail mice appear early after birth. PLoS One 8(7):e67869. [PubMed: 23844115]  [MGI Ref ID J:204304]

Lane PW. 1972. Two new mutations in linkage group XVI of the house mouse. Flaky tail and varitint-waddler-J. J Hered 63(3):135-40. [PubMed: 4557539]  [MGI Ref ID J:5286]

Lane PW; Green MC. 1962. ft - flaky tail Mouse News Lett 27:38.  [MGI Ref ID J:64247]

Moniaga CS; Egawa G; Kawasaki H; Hara-Chikuma M; Honda T; Tanizaki H; Nakajima S; Otsuka A; Matsuoka H; Kubo A; Sakabe J; Tokura Y; Miyachi Y; Amagai M; Kabashima K. 2010. Flaky tail mouse denotes human atopic dermatitis in the steady state and by topical application with Dermatophagoides pteronyssinus extract. Am J Pathol 176(5):2385-93. [PubMed: 20304960]  [MGI Ref ID J:160771]

Nakai K; Yoneda K; Hosokawa Y; Moriue T; Presland RB; Fallon PG; Kabashima K; Kosaka H; Kubota Y. 2012. Reduced expression of epidermal growth factor receptor, E-cadherin, and occludin in the skin of flaky tail mice is due to filaggrin and loricrin deficiencies. Am J Pathol 181(3):969-77. [PubMed: 22796440]  [MGI Ref ID J:188524]

Okano J; Lichti U; Mamiya S; Aronova M; Zhang G; Yuspa SH; Hamada H; Sakai Y; Morasso MI. 2012. Increased retinoic acid levels through ablation of Cyp26b1 determine the processes of embryonic skin barrier formation and peridermal development. J Cell Sci 125(Pt 7):1827-36. [PubMed: 22366455]  [MGI Ref ID J:192725]

Presland RB; Boggess D; Lewis SP; Hull C; Fleckman P; Sundberg JP. 2000. Loss of normal profilaggrin and filaggrin in flaky tail (ft/ft) mice: an animal model for the filaggrin-deficient skin disease ichthyosis vulgaris. J Invest Dermatol 115(6):1072-81. [PubMed: 11121144]  [MGI Ref ID J:66567]

Rice RH; Bradshaw KM; Durbin-Johnson BP; Rocke DM; Eigenheer RA; Phinney BS; Sundberg JP. 2012. Differentiating inbred mouse strains from each other and those with single gene mutations using hair proteomics. PLoS One 7(12):e51956. [PubMed: 23251662]  [MGI Ref ID J:195664]

Sasaki T; Shiohama A; Kubo A; Kawasaki H; Ishida-Yamamoto A; Yamada T; Hachiya T; Shimizu A; Okano H; Kudoh J; Amagai M. 2013. A homozygous nonsense mutation in the gene for Tmem79, a component for the lamellar granule secretory system, produces spontaneous eczema in an experimental model of atopic dermatitis. J Allergy Clin Immunol 132(5):1111-1120.e4. [PubMed: 24060273]  [MGI Ref ID J:202316]

Saunders SP; Goh CS; Brown SJ; Palmer CN; Porter RM; Cole C; Campbell LE; Gierlinski M; Barton GJ; Schneider G; Balmain A; Prescott AR; Weidinger S; Baurecht H; Kabesch M; Gieger C; Lee YA; Tavendale R; Mukhopadhyay S; Turner SW; Madhok VB; Sullivan FM; Relton C; Burn J; Meggitt S; Smith CH; Allen MA; Barker JN; Reynolds NJ; Cordell HJ; Irvine AD; McLean WH; Sandilands A; Fallon PG. 2013. Tmem79/Matt is the matted mouse gene and is a predisposing gene for atopic dermatitis in human subjects. J Allergy Clin Immunol 132(5):1121-9. [PubMed: 24084074]  [MGI Ref ID J:202453]

Savinko T; Matikainen S; Saarialho-Kere U; Lehto M; Wang G; Lehtimaki S; Karisola P; Reunala T; Wolff H; Lauerma A; Alenius H. 2012. IL-33 and ST2 in atopic dermatitis: expression profiles and modulation by triggering factors. J Invest Dermatol 132(5):1392-400. [PubMed: 22277940]  [MGI Ref ID J:184634]

Stout TE; McFarland T; Mitchell JC; Appukuttan B; Timothy Stout J. 2014. Recombinant filaggrin is internalized and processed to correct filaggrin deficiency. J Invest Dermatol 134(2):423-9. [PubMed: 23792461]  [MGI Ref ID J:205734]

Sundberg JP (ed.). 1994. Handbook of Mouse Mutations with Skin and Hair Abnormalities: Animal Models and Biomedical Tools. In: Handbook of Mouse Mutations with Skin and Hair Abnormalities: Animal Models and Biomedical Tools. CRC Press, Boca Raton.  [MGI Ref ID J:30359]

Tmem79ma related

Hogan ME; King LE Jr; Sundberg JP. 1995. Defects of pelage hairs in 20 mouse mutations. J Invest Dermatol 104(5 Suppl):31S-32S. [PubMed: 7738386]  [MGI Ref ID J:25255]

Jarrett A; Spearman RI. 1957. The keratin defect and hair-cycle of a new mutant (matted) in the house-mouse. J Embryol Exp Morphol 5(1):103-110.  [MGI Ref ID J:12995]

Rice RH; Bradshaw KM; Durbin-Johnson BP; Rocke DM; Eigenheer RA; Phinney BS; Sundberg JP. 2012. Differentiating inbred mouse strains from each other and those with single gene mutations using hair proteomics. PLoS One 7(12):e51956. [PubMed: 23251662]  [MGI Ref ID J:195664]

Sasaki T; Shiohama A; Kubo A; Kawasaki H; Ishida-Yamamoto A; Yamada T; Hachiya T; Shimizu A; Okano H; Kudoh J; Amagai M. 2013. A homozygous nonsense mutation in the gene for Tmem79, a component for the lamellar granule secretory system, produces spontaneous eczema in an experimental model of atopic dermatitis. J Allergy Clin Immunol 132(5):1111-1120.e4. [PubMed: 24060273]  [MGI Ref ID J:202316]

Saunders SP; Goh CS; Brown SJ; Palmer CN; Porter RM; Cole C; Campbell LE; Gierlinski M; Barton GJ; Schneider G; Balmain A; Prescott AR; Weidinger S; Baurecht H; Kabesch M; Gieger C; Lee YA; Tavendale R; Mukhopadhyay S; Turner SW; Madhok VB; Sullivan FM; Relton C; Burn J; Meggitt S; Smith CH; Allen MA; Barker JN; Reynolds NJ; Cordell HJ; Irvine AD; McLean WH; Sandilands A; Fallon PG. 2013. Tmem79/Matt is the matted mouse gene and is a predisposing gene for atopic dermatitis in human subjects. J Allergy Clin Immunol 132(5):1121-9. [PubMed: 24084074]  [MGI Ref ID J:202453]

Savinko T; Matikainen S; Saarialho-Kere U; Lehto M; Wang G; Lehtimaki S; Karisola P; Reunala T; Wolff H; Lauerma A; Alenius H. 2012. IL-33 and ST2 in atopic dermatitis: expression profiles and modulation by triggering factors. J Invest Dermatol 132(5):1392-400. [PubMed: 22277940]  [MGI Ref ID J:184634]

Searle AG; Spearman R. 1954. Matted (symbol ma) Mouse News Lett 11:29.  [MGI Ref ID J:24772]

Searle AG; Spearman RI. 1957. 'Matted', a new hair-mutant in the house-mouse: genetics and morphology. J Embryol Exp Morphol 5(1):93-102.  [MGI Ref ID J:12996]

Sundberg JP (ed.). 1994. Handbook of Mouse Mutations with Skin and Hair Abnormalities: Animal Models and Biomedical Tools. In: Handbook of Mouse Mutations with Skin and Hair Abnormalities: Animal Models and Biomedical Tools. CRC Press, Boca Raton.  [MGI Ref ID J:30359]

a related

Baba K; Sakakibara S; Setsu T; Terashima T. 2007. The superficial layers of the superior colliculus are cytoarchitectually and myeloarchitectually disorganized in the reelin-deficient mouse, reeler. Brain Res 1140:205-15. [PubMed: 17173877]  [MGI Ref ID J:120267]

Batchelor AL; Phillips RJ; Searle AG. 1966. A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res 3(3):218-29. [PubMed: 5962396]  [MGI Ref ID J:5021]

Bjorbaek C; Elmquist JK; Frantz JD; Shoelson SE; Flier JS. 1998. Identification of SOCS-3 as a potential mediator of central leptin resistance. Mol Cell 1(4):619-25. [PubMed: 9660946]  [MGI Ref ID J:119803]

Bultman SJ; Klebig ML; Michaud EJ; Sweet HO; Davisson MT; Woychik RP. 1994. Molecular analysis of reverse mutations from nonagouti (a) to black-and-tan (a(t)) and white-bellied agouti (Aw) reveals alternative forms of agouti transcripts. Genes Dev 8(4):481-90. [PubMed: 8125260]  [MGI Ref ID J:16984]

Bultman SJ; Michaud EJ; Woychik RP. 1992. Molecular characterization of the mouse agouti locus. Cell 71(7):1195-204. [PubMed: 1473152]  [MGI Ref ID J:3523]

Bultman SJ; Russell LB; Gutierrez-Espeleta GA; Woychik RP. 1991. Molecular characterization of a region of DNA associated with mutations at the agouti locus in the mouse. Proc Natl Acad Sci U S A 88(18):8062-6. [PubMed: 1896452]  [MGI Ref ID J:16567]

Bundschuh VG; Madry M. 1988. [atwp mutation in an albino mouse substrain (AB/Hum-1)] Z Versuchstierkd 31(6):249-54. [PubMed: 3227730]  [MGI Ref ID J:16568]

Butler AE; Janson J; Soeller WC; Butler PC. 2003. Increased beta-cell apoptosis prevents adaptive increase in beta-cell mass in mouse model of type 2 diabetes: evidence for role of islet amyloid formation rather than direct action of amyloid. Diabetes 52(9):2304-14. [PubMed: 12941770]  [MGI Ref ID J:132530]

Cattanach BM. 1961. A chemically-induced variegated-type position effect in the mouse. Z Vererbungsl 92:165-82. [PubMed: 13877379]  [MGI Ref ID J:160128]

Cropley JE; Suter CM; Beckman KB; Martin DI. 2006. Germ-line epigenetic modification of the murine A vy allele by nutritional supplementation. Proc Natl Acad Sci U S A 103(46):17308-12. [PubMed: 17101998]  [MGI Ref ID J:117156]

De Souza J; Butler AA; Cone RD. 2000. Disproportionate inhibition of feeding in A(y) mice by certain stressors: a cautionary note. Neuroendocrinology 72(2):126-32. [PubMed: 10971147]  [MGI Ref ID J:102986]

Dickie MM. 1969. Mutations at the agouti locus in the mouse. J Hered 60(1):20-5. [PubMed: 5798139]  [MGI Ref ID J:30922]

Duchesnes CE; Naggert JK; Tatnell MA; Beckman N; Marnane RN; Rodrigues JA; Halim A; Pontre B; Stewart AW; Wolff GL; Elliott R; Mountjoy KG. 2009. New Zealand Ginger Mouse: Novel model that associates the tyrp1b pigmentation gene locus with regulation of lean body mass. Physiol Genomics 37(3):164-74. [PubMed: 19293329]  [MGI Ref ID J:146052]

Dunn LC. 1928. A Fifth Allelomorph in the Agouti Series of the House Mouse. Proc Natl Acad Sci U S A 14(10):816-9. [PubMed: 16587414]  [MGI Ref ID J:15011]

Dunn LC. 1945. A New Eye Color Mutant in the Mouse with Asymmetrical Expression. Proc Natl Acad Sci U S A 31(11):343-6. [PubMed: 16578176]  [MGI Ref ID J:13122]

Dunn LC; Macdowell EC; Lebedeff GA. 1937. Studies on Spotting Patterns III. Interaction between Genes Affecting White Spotting and Those Affecting Color in the House Mouse. Genetics 22(2):307-18. [PubMed: 17246842]  [MGI Ref ID J:12954]

Enshell-Seijffers D; Lindon C; Morgan BA. 2008. The serine protease Corin is a novel modifier of the Agouti pathway. Development 135(2):217-25. [PubMed: 18057101]  [MGI Ref ID J:130426]

Feuerer M; Herrero L; Cipolletta D; Naaz A; Wong J; Nayer A; Lee J; Goldfine AB; Benoist C; Shoelson S; Mathis D. 2009. Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters. Nat Med 15(8):930-9. [PubMed: 19633656]  [MGI Ref ID J:152186]

Fujimoto W; Shiuchi T; Miki T; Minokoshi Y; Takahashi Y; Takeuchi A; Kimura K; Saito M; Iwanaga T; Seino S. 2007. Dmbx1 is essential in agouti-related protein action. Proc Natl Acad Sci U S A 104(39):15514-9. [PubMed: 17873059]  [MGI Ref ID J:125193]

Gajewska M; Krysiak E; Wirth-Dziecialowska E. 2010. New coat color mutation mapped in distal part MMU10 MGI Direct Data Submission :.  [MGI Ref ID J:162146]

Galbraith DB; Arceci RJ. 1974. Melanocyte populations of yellow and black hair bulbs in the mouse. J Hered 65(6):381-2. [PubMed: 4448905]  [MGI Ref ID J:5512]

Galbraith DB; Patrignani AM. 1976. Sulfhydryl compounds in melanocytes of yellow (Ay/a), nonagouti (a/a), and agouti (A/A) mice. Genetics 84(3):587-91. [PubMed: 1001879]  [MGI Ref ID J:5737]

Galbraith DB; Wolff GL; Brewer NL. 1980. Hair pigment patterns in different integumental environments of the mouse. Influence of the agouti suppressor (A<s>) mutation on expression of agouti locus alleles. J Hered 71:229-234.  [MGI Ref ID J:12033]

Galbraith DB; Wolff GL; Brewer NL. 1979. Tissue microenvironment and the genetic control of hair pigment patterns in mice Dev Genet 1(2):167-179.  [MGI Ref ID J:156092]

Geschwind II; Huseby RA; Nishioka R. 1972. The effect of melanocyte-stimulating hormone on coat color in the mouse. Recent Prog Horm Res 28:91-130. [PubMed: 4631622]  [MGI Ref ID J:5324]

Granholm DE; Reese RN; Granholm NH. 1996. Agouti alleles alter cysteine and glutathione concentrations in hair follicles and serum of mice (A y/a, A wJ/A wJ, and a/a). J Invest Dermatol 106(3):559-63. [PubMed: 8648194]  [MGI Ref ID J:32132]

Gruneberg H. 1952. . In: The Genetics of the Mouse. Martinus Nijhoff, The Hague.  [MGI Ref ID J:30758]

Heaney JD; Michelson MV; Youngren KK; Lam MY; Nadeau JH. 2009. Deletion of eIF2beta suppresses testicular cancer incidence and causes recessive lethality in agouti-yellow mice. Hum Mol Genet 18(8):1395-404. [PubMed: 19168544]  [MGI Ref ID J:146879]

Hearing VJ; Phillips P; Lutzner MA. 1973. The fine structure of melanogenesis in coat color mutants of the mouse. J Ultrastruct Res 43(1):88-106. [PubMed: 4634048]  [MGI Ref ID J:5346]

Hustad CM; Perry WL; Siracusa LD; Rasberry C; Cobb L; Cattanach BM; Kovatch R; Copeland NG; Jenkins NA. 1995. Molecular genetic characterization of six recessive viable alleles of the mouse agouti locus. Genetics 140(1):255-65. [PubMed: 7635290]  [MGI Ref ID J:24934]

Iwatsuka H; Shino A; Suzuoki Z. 1970. General survey of diabetic features of yellow KK mice. Endocrinol Jpn 17(1):23-35. [PubMed: 5468422]  [MGI Ref ID J:26460]

Jackson IJ; Budd PS; Keighren M; McKie L. 2007. Humanized MC1R transgenic mice reveal human specific receptor function. Hum Mol Genet 16(19):2341-8. [PubMed: 17652101]  [MGI Ref ID J:129904]

Kaelin CB; Xu X; Hong LZ; David VA; McGowan KA; Schmidt-Kuntzel A; Roelke ME; Pino J; Pontius J; Cooper GM; Manuel H; Swanson WF; Marker L; Harper CK; van Dyk A; Yue B; Mullikin JC; Warren WC; Eizirik E; Kos L; O'Brien SJ; Barsh GS; Menotti-Raymond M. 2012. Specifying and sustaining pigmentation patterns in domestic and wild cats. Science 337(6101):1536-41. [PubMed: 22997338]  [MGI Ref ID J:188277]

Kaminen-Ahola N; Ahola A; Maga M; Mallitt KA; Fahey P; Cox TC; Whitelaw E; Chong S. 2010. Maternal ethanol consumption alters the epigenotype and the phenotype of offspring in a mouse model. PLoS Genet 6(1):e1000811. [PubMed: 20084100]  [MGI Ref ID J:156866]

Kappenman KE; Dvoracek MA; Harvison GA; Fuller BB; Granholm NH. 1992. Tyrosinase abundance and activity in murine hairbulb melanocytes of agouti mutants (C57BL/6J-a/a, Ay/a, and AwJ/AwJ). Pigment Cell Res Suppl 2:79-83. [PubMed: 1409442]  [MGI Ref ID J:1295]

Knisely AS; Gasser DL; Silvers WK. 1975. Expression in organ culture of agouti locus genes of the mouse. Genetics 79(3):471-5. [PubMed: 1126628]  [MGI Ref ID J:5533]

Lamoreux ML; Wakamatsu K; Ito S. 2001. Interaction of major coat color gene functions in mice as studied by chemical analysis of eumelanin and pheomelanin. Pigment Cell Res 14(1):23-31. [PubMed: 11277491]  [MGI Ref ID J:103803]

Lane PW. 1989. Mottled agouti-J (am-J) Mouse News Lett 84:89.  [MGI Ref ID J:16570]

Leamy LJ; Hrubant HE. 1971. Effects of alleles at the agouti locus on odontometric traits in the C57BL-6 strain of house mice. Genetics 67(1):87-96. [PubMed: 5556294]  [MGI Ref ID J:16571]

Loosli R. 1963. Tanoid--a new agouti mutant in the mouse. J Hered 54:26-29.  [MGI Ref ID J:13082]

Markert CL; Silvers WK. 1956. The Effects of Genotype and Cell Environment on Melanoblast Differentiation in the House Mouse. Genetics 41(3):429-50. [PubMed: 17247639]  [MGI Ref ID J:12970]

Martin NM; Houston PA; Patterson M; Sajedi A; Carmignac DF; Ghatei MA; Bloom SR; Small CJ. 2006. Abnormalities of the somatotrophic axis in the obese agouti mouse. Int J Obes (Lond) 30(3):430-8. [PubMed: 16172617]  [MGI Ref ID J:151302]

Martinez HG; Quinones MP; Jimenez F; Estrada CA; Clark K; Muscogiuri G; Sorice G; Musi N; Reddick RL; Ahuja SS. 2011. Critical role of chemokine (C-C motif) receptor 2 (CCR2) in the KKAy + Apoe -/- mouse model of the metabolic syndrome. Diabetologia 54(10):2660-8. [PubMed: 21779871]  [MGI Ref ID J:177084]

Mayer TC; Fishbane JL. 1972. Mesoderm-ectoderm interaction in the production of the agouti pigmentation pattern in mice. Genetics 71(2):297-303. [PubMed: 4558326]  [MGI Ref ID J:5288]

Miller MW; Duhl DM; Vrieling H; Cordes SP; Ollmann MM; Winkes BM; Barsh GS. 1993. Cloning of the mouse agouti gene predicts a secreted protein ubiquitously expressed in mice carrying the lethal yellow mutation. Genes Dev 7(3):454-67. [PubMed: 8449404]  [MGI Ref ID J:4186]

Miyazaki M; Sampath H; Liu X; Flowers MT; Chu K; Dobrzyn A; Ntambi JM. 2009. Stearoyl-CoA desaturase-1 deficiency attenuates obesity and insulin resistance in leptin-resistant obese mice. Biochem Biophys Res Commun 380(4):818-22. [PubMed: 19338759]  [MGI Ref ID J:147343]

Monroe DG; Wipf LP; Diggins MR; Matthees DP; Granholm NH. 1998. Agouti-related maturation and tissue distribution of alpha-Melanocyte Stimulating Hormone in wild-type (AwJ/AwJ) and mutant (Ay/a,a/a) mice. Pigment Cell Res 11(5):310-3. [PubMed: 9877102]  [MGI Ref ID J:52183]

Moore KJ; Swing DA; Copeland NG; Jenkins NA. 1990. Interaction of the murine dilute suppressor gene (dsu) with fourteen coat color mutations [published erratum appears in Genetics 1990 Sep;126(1):285] Genetics 125(2):421-30. [PubMed: 2379821]  [MGI Ref ID J:29467]

Moyer FH. 1966. Genetic variations in the fine structure and ontogeny of mouse melanin granules. Am Zool 6(1):43-66. [PubMed: 5902512]  [MGI Ref ID J:5001]

Novak EK; Gautam R; Reddington M; Collinson LM; Copeland NG; Jenkins NA; McGarry MP; Swank RT. 2002. The regulation of platelet-dense granules by Rab27a in the ashen mouse, a model of Hermansky-Pudlak and Griscelli syndromes, is granule-specific and dependent on genetic background. Blood 100(1):128-35. [PubMed: 12070017]  [MGI Ref ID J:77395]

Novak EK; Wieland F; Jahreis GP; Swank RT. 1980. Altered secretion of kidney lysosomal enzymes in the mouse pigment mutants ruby-eye, ruby-eye-2-J, and maroon. Biochem Genet 18(5-6):549-61. [PubMed: 6776948]  [MGI Ref ID J:6422]

Nuotio-Antar AM; Hachey DL; Hasty AH. 2007. Carbenoxolone treatment attenuates symptoms of metabolic syndrome and atherogenesis in obese, hyperlipidemic mice. Am J Physiol Endocrinol Metab 293(6):E1517-28. [PubMed: 17878220]  [MGI Ref ID J:145108]

Papacleovoulou G; Abu-Hayyeh S; Nikolopoulou E; Briz O; Owen BM; Nikolova V; Ovadia C; Huang X; Vaarasmaki M; Baumann M; Jansen E; Albrecht C; Jarvelin MR; Marin JJ; Knisely AS; Williamson C. 2013. Maternal cholestasis during pregnancy programs metabolic disease in offspring. J Clin Invest 123(7):3172-81. [PubMed: 23934127]  [MGI Ref ID J:201610]

Pettitt SJ; Liang Q; Rairdan XY; Moran JL; Prosser HM; Beier DR; Lloyd KC; Bradley A; Skarnes WC. 2009. Agouti C57BL/6N embryonic stem cells for mouse genetic resources. Nat Methods :. [PubMed: 19525957]  [MGI Ref ID J:149352]

Poole TW. 1975. Dermal-epidermal interactions and the action of alleles at the agouti locus in the mouse. Dev Biol 42(2):203-10. [PubMed: 1090472]  [MGI Ref ID J:5519]

Poole TW. 1982. The agouti suppressor (As) coat color mutation in mice: developmental effects on the expression of agouti locus alleles. J Exp Zool 220(1):57-64. [PubMed: 7077265]  [MGI Ref ID J:6763]

Quevedo WC Jr.; Chase HB. 1958. An analysis of the light mutation of coat color in mice. J Morphol 102:329-345.  [MGI Ref ID J:13094]

Quevedo WC Jr; Holstein TJ. 1992. The shift from physiological genetics to molecular genetics in the study of mouse tyrosinase. Pigment Cell Res Suppl 2:57-60. [PubMed: 1409439]  [MGI Ref ID J:3852]

RUSSELL ES. 1949. A quantitative histological study of the pigment found in the coat-color mutants of the house mouse; interdependence among the variable granule attributes. Genetics 34(2):133-45. [PubMed: 18117146]  [MGI Ref ID J:148461]

Rakyan VK; Chong S; Champ ME; Cuthbert PC; Morgan HD; Luu KV; Whitelaw E. 2003. Transgenerational inheritance of epigenetic states at the murine Axin(Fu) allele occurs after maternal and paternal transmission. Proc Natl Acad Sci U S A 100(5):2538-43. [PubMed: 12601169]  [MGI Ref ID J:82396]

Rice RH; Bradshaw KM; Durbin-Johnson BP; Rocke DM; Eigenheer RA; Phinney BS; Sundberg JP. 2012. Differentiating inbred mouse strains from each other and those with single gene mutations using hair proteomics. PLoS One 7(12):e51956. [PubMed: 23251662]  [MGI Ref ID J:195664]

Rosenfeld CS; Sieli PT; Warzak DA; Ellersieck MR; Pennington KA; Roberts RM. 2013. Maternal exposure to bisphenol A and genistein has minimal effect on A(vy)/a offspring coat color but favors birth of agouti over nonagouti mice. Proc Natl Acad Sci U S A 110(2):537-42. [PubMed: 23267115]  [MGI Ref ID J:193279]

Russell ES. 1948. A Quantitative Histological Study of the Pigment Found in the Coat Color Mutants of the House Mouse. II. Estimates of the Total Volume of Pigment. Genetics 33(3):228-36. [PubMed: 17247280]  [MGI Ref ID J:148462]

Russell ES. 1946. A Quantitative Histological Study of the Pigment Found in the Coat-Color Mutants of the House Mouse. I. Variable Attributes of the Pigment Granules. Genetics 31(3):327-46. [PubMed: 17247200]  [MGI Ref ID J:148463]

Russell ES. 1949. A Quantitative Histological Study of the Pigment Found in the Coat-Color Mutants of the House Mouse. IV. the Nature of the Effects of Genic Substitution in Five Major Allelic Series. Genetics 34(2):146-66. [PubMed: 17247308]  [MGI Ref ID J:12958]

Russell LB. 1964. Genetic and Functional Mosaicism in the Mouse. In: The Role of the Chromosomes in Development. Academic Press, New York.  [MGI Ref ID J:29504]

Russell LB; Cupp McDaniel MN; Woodiel FN,. 1963. Crossing over within the a "locus" of the mouse Genetics 48:907 Abstr.  [MGI Ref ID J:174047]

SILVERS WK. 1958. An experimental approach to action of genes at the agouti locus in the mouse. III. Transplants of newborn Aw-, A-and at-skin to Ay-, Aw-, A-and aa hosts. J Exp Zool 137(1):189-96. [PubMed: 13563791]  [MGI Ref ID J:13013]

Sakurai T; Ochiai H; Takeuchi T. 1975. Ultrastructural change of melanosomes associated with agouti pattern formation in mouse hair. Dev Biol 47(2):466-71. [PubMed: 1204945]  [MGI Ref ID J:5606]

Silvers WK. 1979. The Coat Colors of Mice; A Model for Mammalian Gene Action and Interaction. In: The Coat Colors of Mice. Springer-Verlag, New York.  [MGI Ref ID J:78801]

Soeller WC; Janson J; Hart SE; Parker JC; Carty MD; Stevenson RW; Kreutter DK; Butler PC. 1998. Islet amyloid-associated diabetes in obese A(vy)/a mice expressing human islet amyloid polypeptide. Diabetes 47(5):743-50. [PubMed: 9588445]  [MGI Ref ID J:133694]

Staats J. 1985. Standardized Nomenclature for Inbred Strains of Mice: eighth listing. Cancer Res 45(3):945-77. [PubMed: 3971387]  [MGI Ref ID J:50296]

Suto J. 2008. Coincidence of loci for glucosuria and obesity in type 2 diabetes-prone KK-Ay mice. Med Sci Monit 14(2):CR65-74. [PubMed: 18227763]  [MGI Ref ID J:131439]

Suto J. 2009. Identification of multiple quantitative trait loci affecting the size and shape of the mandible in mice. Mamm Genome 20(1):1-13. [PubMed: 19067046]  [MGI Ref ID J:143893]

Suto J; Matsuura S; Imamura K; Yamanaka H; Sekikawa K. 1998. Genetics of obesity in KK mouse and effects of A(y) allele on quantitative regulation. Mamm Genome 9(7):506-10. [PubMed: 9657845]  [MGI Ref ID J:48704]

Suwa A; Yoshino M; Yamazaki C; Naitou M; Fujikawa R; Matsumoto S; Kurama T; Shimokawa T; Aramori I. 2010. RMI1 deficiency in mice protects from diet and genetic-induced obesity. FEBS J 277(3):677-86. [PubMed: 20050919]  [MGI Ref ID J:168271]

Sweet SE; Quevedo WC Jr. 1968. Role of melanocyte morphology in pigmentation of mouse hair. Anat Rec 162(2):243-54. [PubMed: 5726144]  [MGI Ref ID J:5095]

Tamate HB; Takeuchi T. 1981. Induction of the shift in melanin synthesis in lethal yellow (A<y>/a) mice in vitro. Dev Genet 2:349-356.  [MGI Ref ID J:11956]

Tanaka S; Kuwahara S; Nishijima K; Ohno T; Matsuzawa A. 2006. Genetic association of mutation at agouti locus with adrenal x zone morphology in BALB/c mice. Exp Anim 55(4):343-7. [PubMed: 16880681]  [MGI Ref ID J:111619]

Tanaka S; Nishimura M; Matsuzawa A. 1994. Genetic association between agouti locus and adrenal X zone morphology in SM/J mice. Acta Anat (Basel) 149(3):170-3. [PubMed: 7976166]  [MGI Ref ID J:19308]

The Jackson Laboratory Office of Genetic Resources. 1983. Registry of Remutation at The Jackson Laboratory, 1983-1984 MGI Direct Data Submission :.  [MGI Ref ID J:79402]

The Jackson Laboratory Office of Genetic Resourses. 1979. Registry of Remutations at The Jackson Laboratory, 1979-1980 MGI Direct Data Submission :.  [MGI Ref ID J:78474]

The Mammalian Genetics Unit at Harwell. 2004. Information obtained from the Mammalian Genetics Unit, Medical Research Council (MRC), Harwell, UK Unpublished :.  [MGI Ref ID J:90559]

Tsuruta Y; Yoshimatsu H; Hidaka S; Kondou S; Okamoto K; Sakata T. 2002. Hyperleptinemia in A(y)/a mice upregulates arcuate cocaine- and amphetamine-regulated transcript expression. Am J Physiol Endocrinol Metab 282(4):E967-73. [PubMed: 11882520]  [MGI Ref ID J:75872]

Vrieling H; Duhl DM; Millar SE; Miller KA; Barsh GS. 1994. Differences in dorsal and ventral pigmentation result from regional expression of the mouse agouti gene. Proc Natl Acad Sci U S A 91(12):5667-71. [PubMed: 8202545]  [MGI Ref ID J:18750]

Wolff GL. 1978. Influence of maternal phenotype on metabolic differentiation of agouti locus mutants in the mouse. Genetics 88(3):529-39. [PubMed: 640377]  [MGI Ref ID J:5964]

Woychik RP; Generoso WM; Russell LB; Cain KT; Cacheiro NL; Bultman SJ; Selby PB; Dickinson ME; Hogan BL; Rutledge JC. 1990. Molecular and genetic characterization of a radiation-induced structural rearrangement in mouse chromosome 2 causing mutations at the limb deformity and agouti loci. Proc Natl Acad Sci U S A 87(7):2588-92. [PubMed: 2320577]  [MGI Ref ID J:10399]

Wu Q; Howell MP; Cowley MA; Palmiter RD. 2008. Starvation after AgRP neuron ablation is independent of melanocortin signaling. Proc Natl Acad Sci U S A 105(7):2687-92. [PubMed: 18272480]  [MGI Ref ID J:132184]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $2525.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Frozen Products

Price (US dollars $)
Frozen Embryo $1650.00

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryopreserved Embryos
    Available to most shipping destinations1
    This strain is also available as cryopreserved embryos2. Orders for cryopreserved embryos may be placed with our Customer Service Department. Experienced technicians at The Jackson Laboratory have recovered frozen embryos of this strain successfully. We will provide you enough embryos to perform two embryo transfers. The Jackson Laboratory does not guarantee successful recovery at your facility. For complete information on purchasing embryos, please visit our Cryopreserved Embryos web page.

    1 Shipments cannot be made to Australia due to Australian government import restrictions.
    2 Embryos for most strains are cryopreserved at the two cell stage while some strains are cryopreserved at the eight cell stage. If this information is important to you, please contact Customer Service.
  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We willfulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $3283.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Frozen Products

Price (US dollars $)
Frozen Embryo $2145.00

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryopreserved Embryos
    Available to most shipping destinations1
    This strain is also available as cryopreserved embryos2. Orders for cryopreserved embryos may be placed with our Customer Service Department. Experienced technicians at The Jackson Laboratory have recovered frozen embryos of this strain successfully. We will provide you enough embryos to perform two embryo transfers. The Jackson Laboratory does not guarantee successful recovery at your facility. For complete information on purchasing embryos, please visit our Cryopreserved Embryos web page.

    1 Shipments cannot be made to Australia due to Australian government import restrictions.
    2 Embryos for most strains are cryopreserved at the two cell stage while some strains are cryopreserved at the eight cell stage. If this information is important to you, please contact Customer Service.
  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We willfulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.


See Terms of Use tab for General Terms and Conditions


The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
Ordering Information
JAX® Mice
Surgical and Preconditioning Services
JAX® Services
Customer Services and Support
Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
Technical Support Email Form

Terms of Use

Terms of Use


General Terms and Conditions


Contact information

General inquiries regarding Terms of Use

Contracts Administration

phone:207-288-6470

JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


(6.6)