Strain Name:

B6.Cg-Rorasg + +/+ Myo5ad Bmp5se/J

Stock Number:

000285

Order this mouse

Availability:

Cryopreserved - Ready for recovery

Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Type Congenic; Mutant Strain;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Additional information on Congenic nomenclature.
Specieslaboratory mouse
Background Strain C57BL/6J
Donor Strain Bmpse , Commercial breeder; Myo5ad NB strain ; Rorasg NB strain

Appearance
black
Related Genotype: + ? ?/? + +

black , small, wasted in appearance
Related Genotype: Rora sg ? ?/Rorasg + +

slate grey, short ears
Related Genotype: + Myo5ad Bmp5 se/? Myo5ad Bmp5se

Description
Mice homozygous for the staggerer spontaneous mutation (Rorasg) show a staggering gait, mild tremor, hypotonia, and small size. The cerebellar cortex of homozygous mutant mice is grossly underdeveloped with a deficiency of granule cells and Purkinje cells. The remaining granule cells migrate inward from the external layer prematurely and then degenerate. Purkinje cells are much delayed in postnatal differentiation and lack the dendritic spines on which synapses with the parallel fibers from the granule cells normally occur. Staggerer mutant mice have been used as a source of an agranulate cerebellum in a number of investigations of the composition and function of granule cells. Kopmels et al. have reported a hyperproduction of IL1 biological activity and mRNA from LPS stimulated spleen cells of Rorasg/Rorasg mice on the C57BL/6J background relative to wild type siblings.

In this congenic strain the staggerer mutation is maintained in repulsionwith both the dilute (Myo5ad) and short ear (Bmp5se) mutations.

Control Information

  Control
   Untyped from the colony
   000664 C57BL/6J
 
  Considerations for Choosing Controls

Related Strains

Strains carrying   Bmp5se allele
000004   ABP/LeJ
000578   B6 x STOCK Tyrc-ch Bmp5se +/+ Myo6sv/J
000056   B6.Cg-Bmp5se/J
000652   BDP/J
000253   DLS/LeJ
000679   P/J
000644   SEA/GnJ
000270   SEC/1GnLeJ
View Strains carrying   Bmp5se     (8 strains)

Strains carrying   Myo5ad allele
001005   AKXD1/TyJ
001003   AKXD11/TyJ
000765   AKXD13/TyJ
000779   AKXD14/TyJ
000954   AKXD15/TyJ
001093   AKXD18/TyJ
000776   AKXD2/TyJ
001062   AKXD21/TyJ
000947   AKXD22/TyJ
000949   AKXD25/TyJ
000764   AKXD27/TyJ
000959   AKXD3/TyJ
012889   B6N;TKDU-Myo5ad Cacna2d2du/J
000652   BDP/J
000036   BXD1/TyJ
000013   BXD16/TyJ
000015   BXD18/TyJ
000010   BXD19/TyJ
000077   BXD21/TyJ
000043   BXD22/TyJ
000081   BXD25/TyJ
000029   BXD29-Tlr4lps-2J/J
010981   BXD29/Ty
000037   BXD5/TyJ
000007   BXD6/TyJ
000084   BXD8/TyJ
000105   BXD9/TyJ
000284   CWD/LeJ
000670   DBA/1J
000671   DBA/2J
000963   DBA/2J-Myo5ad+17J/Myo5ad/J
000964   DBA/2J-Myo5ad+18J/Myo5ad/J
000067   DBA/2J-Myo5ad+2J/Myo5ad/J
000673   HRS/J
000674   I/LnJ
001850   MEV-Q/TyJ
001855   MEV-V/TyJ
003345   MEV/2Ty-Emv64/J
000679   P/J
000644   SEA/GnJ
000390   STOCK Myo5ad Ds/J
000994   STOCK a Myo5ad Mregdsu/J
000286   STOCK a/a Myo5ad fd/+ +/J
View Strains carrying   Myo5ad     (43 strains)

Strains carrying   Rorasg allele
002651   B6.C3(Cg)-Rorasg/J
000237   B6C3Fe a/a-Rorasg/J
View Strains carrying   Rorasg     (2 strains)

Strains carrying other alleles of Bmp5
001496   B6(Cg)-Bmp5se-4J/J
005348   BALB/cByJ Agtpbp1pcd-3J-Bmp5cfe-se6J/GrsrJ
005420   C;129S7 Gt(ROSA)26Sor-Bmp5cfe-se7J/GrsrJ
005421   CBy;B6-Bmp5cfe-se8J/GrsrJ
View Strains carrying other alleles of Bmp5     (4 strains)

Strains carrying other alleles of Myo5a
005012   A.B6 Tyr+-Myo5ad-l31J/J
001013   B10.D2/nSnJ-Myo5ad-n/J
000502   B6 x B6CBCa Aw-J/A-Myo5aflr Gnb5flr/J
000963   DBA/2J-Myo5ad+17J/Myo5ad/J
000964   DBA/2J-Myo5ad+18J/Myo5ad/J
000067   DBA/2J-Myo5ad+2J/Myo5ad/J
000253   DLS/LeJ
View Strains carrying other alleles of Myo5a     (7 strains)

Strains carrying other alleles of Rora
005047   C57BL/6J-Rorasg-3J/J
View Strains carrying other alleles of Rora     (1 strain)

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested.
Griscelli Syndrome, Type 1; GS1   (MYO5A)
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

Rorasg/Rora+

        involves: C57BL/6J
  • behavior/neurological phenotype
  • abnormal spatial learning
    • mice exhibit impaired spatial learning in a Z-maze filled with water compared with wild-type mice   (MGI Ref ID J:30686)

Rorasg/Rora+

        involves: C57BL
  • nervous system phenotype
  • abnormal cerebellum morphology   (MGI Ref ID J:1431)
    • abnormal cerebellar layer morphology   (MGI Ref ID J:1431)
      • abnormal cerebellar granule layer morphology
        • granule cell layer decreases with age   (MGI Ref ID J:1431)
        • cell density is reduced   (MGI Ref ID J:1431)
        • decreased cerebellar granule cell number
          • cell numbers are about 35% of controls   (MGI Ref ID J:1431)
      • decreased Purkinje cell number
        • significant loss of Purkinje cells at 1 year of age   (MGI Ref ID J:1431)
    • small cerebellum
      • decreased cross-sectional area of the cerebellum at 1 year of age   (MGI Ref ID J:1431)
  • abnormal inferior olivary complex morphology
    • neuron counts are 60% of controls at 1 year of age   (MGI Ref ID J:1431)

Rorasg/Rorasg

        involves: obese stock
  • mortality/aging
  • partial postnatal lethality
    • about 50% of mutants die by weaning   (MGI Ref ID J:13140)
  • nervous system phenotype
  • abnormal brain morphology   (MGI Ref ID J:13140)
    • abnormal cerebellum morphology
      • cerebellum of adults shows tiny folia with indistinct fissures   (MGI Ref ID J:13140)
      • cerebellum is less than one-third the size of wild-type littermates   (MGI Ref ID J:13140)
      • adult cerebellar cell surface with embryonic characteristics   (MGI Ref ID J:6068)
      • cells agglutinable with wheat germ agglutinin but not wit h Con-A   (MGI Ref ID J:6068)
      • abnormal cerebellar foliation   (MGI Ref ID J:13140)
      • abnormal cerebellar layer morphology   (MGI Ref ID J:5304)
        • abnormal Purkinje cell morphology
          • cells are randomly oriented   (MGI Ref ID J:121314)
          • poorly elaborated dendritic trees   (MGI Ref ID J:121314)
        • abnormal cerebellar granule layer morphology
          • granular cell layer displays a paucity of cells in mutants   (MGI Ref ID J:13140)
          • abnormal cerebellar granule cell morphology
            • external granule layer less developed at birth   (MGI Ref ID J:5304)
            • reduced rate of cell proliferation at 1 and 5 days of age   (MGI Ref ID J:5304)
            • cells migrate prematurely from the external granule layer having undergone fewer cell divisions   (MGI Ref ID J:5304)
            • conspicuous differences in the internal granule layer at 10 days of age   (MGI Ref ID J:5304)
            • decreased cerebellar granule cell number
              • 25% reduction in granule cells in the internal granule cell layer   (MGI Ref ID J:5304)
        • abnormal cerebellar molecular layer   (MGI Ref ID J:13140)
          • thin cerebellar molecular layer   (MGI Ref ID J:13140)
      • small cerebellum   (MGI Ref ID J:13140)
        • weight is significantly less than controls even before neurological symptoms appear   (MGI Ref ID J:5304)
        • less than half of control weight at 5 days of age   (MGI Ref ID J:5304)
    • abnormal cochlear VIII nucleus morphology
      • cochlear nuclei are reduced in volume and severely malformed   (MGI Ref ID J:121314)
      • dendritic spines are rare on cartwheel cells at 1 month of age   (MGI Ref ID J:121314)
      • cartwheel cells are rarely seen in adults   (MGI Ref ID J:121314)
    • abnormal olfactory bulb morphology
      • fewer astrocytes found   (MGI Ref ID J:55239)
      • dendro-dendritic asymmetrical synapses are abundant   (MGI Ref ID J:55239)
      • abnormal olfactory bulb layer morphology   (MGI Ref ID J:55239)
        • abnormal olfactory bulb external plexiform layer morphology
          • thinner than controls   (MGI Ref ID J:55239)
          • lower density of secondary dendrites   (MGI Ref ID J:55239)
          • large, empty, intercellular spaces   (MGI Ref ID J:55239)
        • abnormal olfactory bulb glomerular layer morphology
          • thinner than controls   (MGI Ref ID J:55239)
          • glomerular surface reduced about 15%   (MGI Ref ID J:55239)
          • reduced cell number and intercellular space   (MGI Ref ID J:55239)
          • reduced number of interneuronal relays   (MGI Ref ID J:55239)
        • abnormal olfactory bulb granule cell layer morphology
          • composed of several layers of anaxonal interneurons with smaller than normal cell bodies   (MGI Ref ID J:55239)
          • nuclear size is smaller than controls   (MGI Ref ID J:55239)
          • abnormal olfactory bulb granule cell morphology
            • pycnotic nuclei   (MGI Ref ID J:55239)
            • vacuolations and ruptured membranes   (MGI Ref ID J:55239)
        • abnormal olfactory bulb internal plexiform layer morphology
          • thinner than controls   (MGI Ref ID J:55239)
          • less distinct   (MGI Ref ID J:55239)
        • abnormal olfactory bulb mitral cell layer morphology
          • somewhat discontinuous   (MGI Ref ID J:55239)
        • abnormal olfactory bulb outer nerve layer morphology
          • glial cells with more processes ensheathing axons in the nerve layer   (MGI Ref ID J:55239)
      • small olfactory bulb
        • volume slightly reduced   (MGI Ref ID J:55239)
  • abnormal nervous system physiology
    • immunoreactive somatostatin is significantly elevated in both the cerebrum and in the cerebellum   (MGI Ref ID J:28478)
  • behavior/neurological phenotype
  • abnormal motor capabilities/coordination/movement   (MGI Ref ID J:13140)
    • abnormal gait
      • gait is shuffling and hesitant, interrupted every few steps by lurching motions side-to-side   (MGI Ref ID J:13140)
      • abnormal gait is apparent at ~2 weeks of age   (MGI Ref ID J:13140)
    • abnormal limb posture
      • some animals have hindlimbs held abducted and everted at 45 degrees at rest   (MGI Ref ID J:13140)
    • ataxia   (MGI Ref ID J:13140)
      • clearly visible in all mice   (MGI Ref ID J:46854)
      • mice stumble at a rate 40 times greater than WT mice   (MGI Ref ID J:46854)
      • treatment with a thyrotropin releasing hormone analog improves ataxia (fewer falls in a given distance travelled)   (MGI Ref ID J:18435)
    • decreased grip strength
      • mice have a mean hanging time of 12 seconds compared to over 3 minutes for WT mice   (MGI Ref ID J:46854)
    • hypoactivity
      • mutants remain stationary much more than littermates   (MGI Ref ID J:13140)
    • impaired coordination   (MGI Ref ID J:13140)
      • mice fall off an elevated rod on average of 13 seconds compared to over 3 minutes for WT mice   (MGI Ref ID J:46854)
    • limb grasping
      • is observed in all mice   (MGI Ref ID J:46854)
    • tremors
      • mild tremors accompany initiation of movement   (MGI Ref ID J:13140)
  • abnormal motor learning
    • mice have an impaired ability to learn how to hang onto a rotating rod   (MGI Ref ID J:46854)
    • mice hang onto the rod as opposed the walking strategy WT mice exclusively use   (MGI Ref ID J:46854)
    • scores do not improve with 10 days of training   (MGI Ref ID J:46854)
  • growth/size/body phenotype
  • decreased body size
    • mutants are smaller than littermates   (MGI Ref ID J:13140)
  • homeostasis/metabolism phenotype
  • abnormal hormone level
    • prothyrotropin releasing hormone levels are elevated in the thalamus, cerebellum, brainstem, and spinal cord   (MGI Ref ID J:28467)

Rorasg/Rorasg

        involves: C57BL/6
  • homeostasis/metabolism phenotype
  • abnormal lipid homeostasis
    • plasma APOA1 and APOA2 concentrations are approximately 2 fold lower than in wild-type controls on a normal diet, and the Apoa1 mRNA level in intestine is diminished relative to wild-type, although liver expression of Apoa1 is comparable with wild-type   (MGI Ref ID J:52105)
    • the production rate of APOA1 is diminished, but the fractional catabolic rate is comparable to wild-type   (MGI Ref ID J:52105)
    • decreased circulating cholesterol level
      • plasma total cholesterol levels are significantly lower in both male and female homozygotes than in wild-type controls   (MGI Ref ID J:52105)
      • although cholesterol levels increase on an atherosclerotic diet, homozygotes still have lower plasma cholesterol than wild-type controls also fed this diet   (MGI Ref ID J:52105)
      • decreased circulating HDL cholesterol level
        • plasma HDL cholesterol level is significantly lower in both male and female homozygotes than in wild-type controls, and females have significantly lower plasma HDL level than males both for the homozygous and wild-type data sets. This is true even on an atherogenic diet.   (MGI Ref ID J:52105)
  • cardiovascular system phenotype
  • abnormal vasoconstriction
    • contractions of the mesenteric artery induced by phenylephrin or serotonin are less than in controls   (MGI Ref ID J:109735)
  • abnormal vasodilation
    • blood flow induced dilation of the mesenteric artery is less than for controls   (MGI Ref ID J:109735)
    • endothelium-dependent and independent dilation is reduced   (MGI Ref ID J:109735)
  • atherosclerotic lesions
    • the atherosclerotic lesions induced in homozygotes by 9 weeks of an atherosclerotic diet have a 6 fold greater area in female homozygotes and a 7.5 fold greater area in male homozygotes than those in wild-type controls on the same diet   (MGI Ref ID J:52105)
    • increased susceptibility to atherosclerosis
      • Although homozygotes fed a normal diet do not display abnormal atherosclerotic lesions, 9 weeks of an atherosclerotic diet induces exaggerated altherosclerotic lesions compared with wild-type controls on the atherosclerotic diet   (MGI Ref ID J:52105)
  • decreased mean systemic arterial blood pressure
    • 80mmHg vs 87mmHg for controls   (MGI Ref ID J:109735)
    • phenylephrine causes less blood pressure increase than in controls   (MGI Ref ID J:109735)
    • acetyl choline causes less blood pressure decrease than in controls   (MGI Ref ID J:109735)
  • increased angiogenesis
    • significantly increased in the ischemic leg 28 days after femoral artery ligature   (MGI Ref ID J:115425)
    • 80% rise in vascular density relative to controls   (MGI Ref ID J:115425)
    • 3 fold increase in capillary density relative to controls   (MGI Ref ID J:115425)
  • immune system phenotype
  • *normal* immune system phenotype
    • white blood cell, lymphocyte, and neutrophil counts are not significantly different between homozygotes and wild-type controls   (MGI Ref ID J:52105)
    • abnormal immune system organ morphology   (MGI Ref ID J:2228)
      • spleen atrophy   (MGI Ref ID J:2228)
      • thymus atrophy   (MGI Ref ID J:2228)
    • abnormal immune system physiology
      • abnormal immune responses   (MGI Ref ID J:2228)
      • abnormal macrophage physiology
        • LPS stimulated macrophage produce 2 fold more IL-1 relative to macrophage of controls   (MGI Ref ID J:28095)
      • increased IgE level
        • levels are elevated in unsensitized mice   (MGI Ref ID J:135863)
        • OVA sensitization causes an additional elevation in IgE levels   (MGI Ref ID J:135863)
        • OVA challenge of sensitized mice causes a very great increase in IgE levels   (MGI Ref ID J:135863)
      • increased interleukin-1 secretion
        • LPS stimulated macrophage produce 2 fold more IL-1 relative to macrophage of controls   (MGI Ref ID J:28095)
      • lung inflammation
        • OVA sensitized and challenged mice experience less infiltration of lymphocytes and polymorphonuclear cells into peribronchiolar and perivascular regions of the lungs   (MGI Ref ID J:135863)
        • less alveolar infiltration as well   (MGI Ref ID J:135863)
        • less increase of inflammatory cells in bronchoalveolar lavage   (MGI Ref ID J:135863)
        • less increase of IL-4, IL-5, and IL-13   (MGI Ref ID J:135863)
  • nervous system phenotype
  • abnormal cerebellum morphology
    • embryonic, high sialic acid forms of N-CAM persist on cell surfaces to 14 and 21 days of age   (MGI Ref ID J:6930)
  • abnormal inferior olivary complex morphology
    • individual olivary subnuclei are poorly defined relative to controls   (MGI Ref ID J:20982)
    • definition of subnuclei is better in 21 day old mice but regresses in adults   (MGI Ref ID J:20982)
    • olivary dendrites tend to be multipolar and well branched   (MGI Ref ID J:20982)
    • number of neurons drops 30% within 3 days of birth and continues to decline for 2 months   (MGI Ref ID J:20982)
    • number of neurons in adults is decreased 60% relative to newborns   (MGI Ref ID J:20982)
    • adult cell bodies are smaller than in newborns   (MGI Ref ID J:20982)
    • inferior olive extends further dorsally in the midline   (MGI Ref ID J:28468)
    • decreased cell density   (MGI Ref ID J:28468)
  • reproductive system phenotype
  • abnormal external female genitalia morphology
    • vaginal opening averaged 35 days (never earlier than 31 days) while controls averaged 28 days (earliest 26 days)   (MGI Ref ID J:1960)
  • abnormal female reproductive system physiology   (MGI Ref ID J:1960)
    • abnormal estrous cycle
      • irregular cycles   (MGI Ref ID J:1960)
      • delayed estrous cycle
        • onset of estrus at 45 days vs 40 days for controls   (MGI Ref ID J:1960)
      • prolonged estrus
        • prolonged vaginal estrus relative to controls   (MGI Ref ID J:1960)
      • prolonged metestrus   (MGI Ref ID J:1960)
    • reduced female fertility
      • no females mate before 2.5 months of age   (MGI Ref ID J:1960)
      • females sexual activity decreases after 4.5 months   (MGI Ref ID J:1960)
      • only one of 10 females still mating at 6 months of age   (MGI Ref ID J:1960)
  • abnormal fertility/fecundity
    • some couples receiving vestibular stimulation mated between the ages of 36 and 89 days of age   (MGI Ref ID J:14535)
    • no unstimulated couples mated   (MGI Ref ID J:14535)
    • reduced female fertility
      • no females mate before 2.5 months of age   (MGI Ref ID J:1960)
      • females sexual activity decreases after 4.5 months   (MGI Ref ID J:1960)
      • only one of 10 females still mating at 6 months of age   (MGI Ref ID J:1960)
  • abnormal male reproductive system physiology
    • vestibular stimulation improves the ability of males to mate with experienced females   (MGI Ref ID J:14535)
    • one to two months of social isolation results in increased mounting behavior when a receptive female is encountered   (MGI Ref ID J:26698)
    • successful mating occurs from 35-160 days after the end of male isolation   (MGI Ref ID J:26698)
  • behavior/neurological phenotype
  • abnormal maternal nurturing
    • females from heterozygous parents fail to nurture pups to weaning   (MGI Ref ID J:14497)
    • females from selected homozygous lineages sometimes (9/14) raise pups to weaning although growth rate of pups is lower than normal   (MGI Ref ID J:14497)
  • abnormal spatial learning
    • higher latency to escape at all time tested using two types of water maze   (MGI Ref ID J:30012)
    • less age related degradation in latency to escape although it is always greater than in controls   (MGI Ref ID J:30012)
  • respiratory system phenotype
  • abnormal lung compliance
    • lung resistance in response to methacholine challenge of OVA exposed mice fails to increase   (MGI Ref ID J:135863)
  • abnormal respiratory mucosa morphology
    • less mucous cell hyperplasia in airways after OVA exposure of sensitized mice   (MGI Ref ID J:135863)
  • lung inflammation
    • OVA sensitized and challenged mice experience less infiltration of lymphocytes and polymorphonuclear cells into peribronchiolar and perivascular regions of the lungs   (MGI Ref ID J:135863)
    • less alveolar infiltration as well   (MGI Ref ID J:135863)
    • less increase of inflammatory cells in bronchoalveolar lavage   (MGI Ref ID J:135863)
    • less increase of IL-4, IL-5, and IL-13   (MGI Ref ID J:135863)
  • taste/olfaction phenotype
  • *normal* taste/olfaction phenotype
    • male mice are able to distinguish between the vaginal secretions of estrus and non-estrus females   (MGI Ref ID J:15645)
    • abnormal olfaction
      • aversive threshold concentration for butanol is increased   (MGI Ref ID J:39053)
      • attractive threshold concentration for vanillin is increased   (MGI Ref ID J:39053)
      • amyl alchohol odor induced evoked field potential shows an increased latency preceding the functional response of mitral cells in the olfactory bulb   (MGI Ref ID J:107925)
      • N1 and N2 response amplitudes of the evoked field potential are significantly reduced   (MGI Ref ID J:107925)
  • hematopoietic system phenotype
  • abnormal macrophage physiology
    • LPS stimulated macrophage produce 2 fold more IL-1 relative to macrophage of controls   (MGI Ref ID J:28095)
  • increased IgE level
    • levels are elevated in unsensitized mice   (MGI Ref ID J:135863)
    • OVA sensitization causes an additional elevation in IgE levels   (MGI Ref ID J:135863)
    • OVA challenge of sensitized mice causes a very great increase in IgE levels   (MGI Ref ID J:135863)
  • spleen atrophy   (MGI Ref ID J:2228)
  • thymus atrophy   (MGI Ref ID J:2228)
  • muscle phenotype
  • abnormal vasoconstriction
    • contractions of the mesenteric artery induced by phenylephrin or serotonin are less than in controls   (MGI Ref ID J:109735)
  • abnormal vasodilation
    • blood flow induced dilation of the mesenteric artery is less than for controls   (MGI Ref ID J:109735)
    • endothelium-dependent and independent dilation is reduced   (MGI Ref ID J:109735)
  • endocrine/exocrine gland phenotype
  • thymus atrophy   (MGI Ref ID J:2228)

Rorasg/Rorasg

        involves: C57BL
  • nervous system phenotype
  • abnormal cerebellum morphology
    • cell surface antigen characteristics more embryonic in nature   (MGI Ref ID J:6088)
    • abnormal cerebellar layer morphology   (MGI Ref ID J:5968)
      • abnormal cerebellar Purkinje cell layer
        • Purkinje cell band thicker at 3 days of age   (MGI Ref ID J:5968)
        • abnormal Purkinje cell morphology
          • cells smaller in size with thinner processes   (MGI Ref ID J:5968)
          • larger, typical Purkinje cells are absent in intermediate regions of the cerebellum   (MGI Ref ID J:6185)
          • 60-90% of Purkinje cells are lost   (MGI Ref ID J:6185)
          • multiple climbing fiber synaptic connections to each Purkinje cell are maintained   (MGI Ref ID J:6260)
          • abnormal Purkinje cell dendrite morphology
            • no synapses form between Purkinje cell spines and the parallel fibers at 14 to 43 days of age   (MGI Ref ID J:5968)
            • reduced growth of dendrite arbor   (MGI Ref ID J:5968)
          • abnormal Purkinje cell differentiation
            • retarded   (MGI Ref ID J:5968)
        • delaminated Purkinje cell layer
          • typical laminar array fails to form   (MGI Ref ID J:5968)
      • abnormal cerebellar granule layer morphology   (MGI Ref ID J:5968)
        • abnormal cerebellar granule cell morphology
          • no synapses form between the parallel fibers and the Purkinje cell spines at 14 to 43 days of age   (MGI Ref ID J:5968)
          • synapses do develop between parallel fibers and stellate and basket cells   (MGI Ref ID J:5968)
          • degenerating parallel fibers begin to appear around 7 days and is well advanced by 14 days   (MGI Ref ID J:5968)
        • thin cerebellar granule layer   (MGI Ref ID J:5968)
      • thin cerebellar molecular layer   (MGI Ref ID J:5968)
    • abnormal cerebellum deep nucleus morphology
      • white matter in deep cerebellar nuclei is reduced to 42% of controls   (MGI Ref ID J:6554)
      • area occupied by deep neurons is reduced to 36% of controls but cell numbers are not reduced   (MGI Ref ID J:6554)
      • neurons in the deep nuclei are smaller than seen in controls   (MGI Ref ID J:6554)
    • small cerebellum
      • 62% of normal weight at birth   (MGI Ref ID J:6875)
      • weight is 36% of normal at 7 days   (MGI Ref ID J:6875)
  • abnormal neurotransmitter level
    • taurine and aspartate levels decline between 7 and 10 days   (MGI Ref ID J:6875)
    • low levels persist   (MGI Ref ID J:6875)
    • GABA levels in deep cerebellar nuclei are reduced at all ages examined   (MGI Ref ID J:6875)
    • GABA levels are 52% of controls at 7 days and 30% at 3 weeks   (MGI Ref ID J:6875)
    • abnormal synaptic glutamate release
      • glutamate levels drop between 7 and 10 days   (MGI Ref ID J:6875)
      • levels continue to drop over time   (MGI Ref ID J:6875)
  • homeostasis/metabolism phenotype
  • abnormal noradrenaline level
    • significantly elevated in cerebellum   (MGI Ref ID J:164122)
    • significantly elevated in cerebral cortex   (MGI Ref ID J:164122)
    • measurably increased in the spinal cord   (MGI Ref ID J:164122)
  • cellular phenotype
  • abnormal Purkinje cell differentiation
    • retarded   (MGI Ref ID J:5968)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Bmp5se related

Developmental Biology Research
Craniofacial and Palate Defects
Growth Defects
Skeletal Defects

Myo5ad related

Dermatology Research
Color and White Spotting Defects

Rorasg related

Neurobiology Research
Ataxia (Movement) Defects
Cerebellar Defects
      Purkinje cell defect
Receptor Defects
Tremor Defects

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Bmp5se
Allele Name short ear
Allele Type Spontaneous
Common Name(s) seGnJ;
Strain of Originmice from Abbie Lathrop mouse farm
Gene Symbol and Name Bmp5, bone morphogenetic protein 5
Chromosome 9
Gene Common Name(s) AU023399; expressed sequence AU023399; se; short ear;
General Note Phenotypic Similarity to Human Syndrome: Ear, Patella, Short Stature Syndrome (Meier-Gorlin Syndrome) in homozygous mice (J:24474)
Molecular Note The C to T transition creates a stop codon at amino acid 208. The resulting truncated protein does not include the carboxy terminal signaling portion of the molecule. [MGI Ref ID J:21484]
 
Allele Symbol Myo5ad
Allele Name dilute
Allele Type Spontaneous
Common Name(s) Maltese dilution; blue dilution; d; dv;
Strain of Originold mutant of the mouse fancy
Gene Symbol and Name Myo5a, myosin VA
Chromosome 9
Gene Common Name(s) 9630007J19Rik; AI413174; AI661011; D; Dbv; Dop; GS1; MVa; MYH12; MYO5; MYR12; Myo5; MyoVA; RIKEN cDNA 9630007J19 gene; d; dilute; expressed sequence AI413174; expressed sequence AI661011; flail; flailer; flr; myosin V; nmf244;
Molecular Note This mutation is the result of the integration of ecotropic murine leukemia virus Emv-3 into a noncoding region of the Myo5ad gene. Reversions of Myo5ad to wild-type are caused by excision of the virus leaving exactly one long terminal repeat in place. [MGI Ref ID J:6587] [MGI Ref ID J:7092] [MGI Ref ID J:7751]
 
Allele Symbol Rorasg
Allele Name staggerer
Allele Type Spontaneous
Common Name(s) RORalpha-; sg;
Strain of Originobese stock
Gene Symbol and Name Rora, RAR-related orphan receptor alpha
Chromosome 9
Gene Common Name(s) 9530021D13Rik; NR1F1; RIKEN cDNA 9530021D13 gene; ROR1; ROR2; ROR3; RZR-ALPHA; RZRA; Tennessee Mouse Genome Consortium 26; neuroscience mutagenesis facility, 267; nmf267; sg; staggerer; tmgc26;
Molecular Note This allele contains a 6.5kb genomic deletion of an exon encoding part of the ligand binding domain. The deletion results in an exon-skipping event that introduces a shift in the reading frame. The resulting protein is predicted to be truncated due to introduction of a premature stop codon. [MGI Ref ID J:31470]

Genotyping

Genotyping Information

Genotyping Protocols

Rorasg, Standard PCR


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Additional References

Bmp5se related

Cattanach BM. 1961. A chemically-induced variegated-type position effect in the mouse. Z Vererbungsl 92:165-82. [PubMed: 13877379]  [MGI Ref ID J:160128]

Deol MS; Green MC. 1966. Snell's waltzer, a new mutation affecting behaviour and the inner ear in the mouse. Genet Res 8(3):339-45. [PubMed: 5980120]  [MGI Ref ID J:5044]

DiLeone RJ; Russell LB; Kingsley DM. 1998. An extensive 3' regulatory region controls expression of Bmp5 in specific anatomical structures of the mouse embryo. Genetics 148(1):401-8. [PubMed: 9475750]  [MGI Ref ID J:45426]

GREEN MC. 1958. Effects of the short ear gene in the mouse on cartilage formation in healing bone fractures. J Exp Zool 137(1):75-88. [PubMed: 13563786]  [MGI Ref ID J:13011]

Green EL; Green MC. 1946. Effect of the short ear gene on number of ribs and presacral vertebrae in the house mouse Am Naturalist 80:619-25.  [MGI Ref ID J:100198]

Green EL; Green MC. 1942. The development of three manifestations of the short ear gene in the mouse J Morphol 70:1-19.  [MGI Ref ID J:15478]

Green MC. 1951. Further morphological effects of the short ear gene in the house mouse. J Morphol 88:1-22.  [MGI Ref ID J:13091]

Green MC. 1968. Mechanism of the pleiotropic effects of the short-ear mutant gene in the mouse. J Exp Zool 167(2):129-50. [PubMed: 5692092]  [MGI Ref ID J:5086]

Hashimoto M; Morita H; Ueno N. 2014. Molecular and cellular mechanisms of development underlying congenital diseases. Congenit Anom (Kyoto) 54(1):1-7. [PubMed: 24666178]  [MGI Ref ID J:209580]

Johnson DR. 1976. The interfrontal bone and mutant genes in the mouse. J Anat 121(3):507-13. [PubMed: 1018005]  [MGI Ref ID J:5776]

Jones JM; Huang JD; Mermall V; Hamilton BA; Mooseker MS; Escayg A; Copeland NG; Jenkins NA; Meisler MH. 2000. The mouse neurological mutant flailer expresses a novel hybrid gene derived by exon shuffling between Gnb5 and Myo5a. Hum Mol Genet 9(5):821-8. [PubMed: 10749990]  [MGI Ref ID J:61324]

Kangsamaksin T; Morris RJ. 2011. Bone morphogenetic protein 5 regulates the number of keratinocyte stem cells from the skin of mice. J Invest Dermatol 131(3):580-5. [PubMed: 21179110]  [MGI Ref ID J:182086]

Katagiri T; Boorla S; Frendo JL; Hogan BL; Karsenty G. 1998. Skeletal abnormalities in doubly heterozygous Bmp4 and Bmp7 mice. Dev Genet 22(4):340-8. [PubMed: 9664686]  [MGI Ref ID J:48538]

King JA; Marker PC; Seung KJ; Kingsley DM. 1994. BMP5 and the molecular, skeletal, and soft-tissue alterations in short ear mice. Dev Biol 166(1):112-22. [PubMed: 7958439]  [MGI Ref ID J:21484]

Kingsley DM; Bland AE; Grubber JM; Marker PC; Russell LB; Copeland NG; Jenkins NA. 1992. The mouse short ear skeletal morphogenesis locus is associated with defects in a bone morphogenetic member of the TGF beta superfamily. Cell 71(3):399-410. [PubMed: 1339316]  [MGI Ref ID J:3046]

Lacombe D; Toutain A; Gorlin RJ; Oley CA; Battin J. 1994. Clinical identification of a human equivalent to the short ear (se) murine phenotype. Ann Genet 37(4):184-91. [PubMed: 7710253]  [MGI Ref ID J:24474]

Lynch CJ. 1921. Short ears, an autosomal mutation in the house mouse Am Naturalist 55:421-426.  [MGI Ref ID J:14849]

Nadeau JH. 2001. Modifier genes in mice and humans. Nat Rev Genet 2(3):165-74. [PubMed: 11256068]  [MGI Ref ID J:88013]

Oak Ridge National Laboratory. 2005. Information obtained from the Oak Ridge National Laboratory Mutant Mouse Database (ORNL), Oak Ridge, TN Unpublished :.  [MGI Ref ID J:100221]

Pfendler KC; Yoon J; Taborn GU; Kuehn MR; Iannaccone PM. 2000. Nodal and bone morphogenetic protein 5 interact in murine mesoderm formation and implantation. Genesis 28(1):1-14. [PubMed: 11020711]  [MGI Ref ID J:65690]

Russell LB. 1971. Definition of functional units in a small chromosomal segment of the mouse and its use in interpreting the nature of radiation-induced mutations. Mutat Res 11(1):107-23. [PubMed: 5556347]  [MGI Ref ID J:12013]

Sloane JA; Vartanian TK. 2007. Myosin Va controls oligodendrocyte morphogenesis and myelination. J Neurosci 27(42):11366-75. [PubMed: 17942731]  [MGI Ref ID J:126066]

Solloway MJ; Dudley AT; Bikoff EK; Lyons KM; Hogan BL; Robertson EJ. 1998. Mice lacking Bmp6 function. Dev Genet 22(4):321-39. [PubMed: 9664685]  [MGI Ref ID J:48561]

Solloway MJ; Robertson EJ. 1999. Early embryonic lethality in Bmp5;Bmp7 double mutant mice suggests functional redundancy within the 60A subgroup. Development 126(8):1753-68. [PubMed: 10079236]  [MGI Ref ID J:53294]

The Mammalian Genetics Unit at Harwell. 2004. Information obtained from the Mammalian Genetics Unit, Medical Research Council (MRC), Harwell, UK Unpublished :.  [MGI Ref ID J:90559]

Tilleman H; Hakim V; Novikov O; Liser K; Nashelsky L; Di Salvio M; Krauthammer M; Scheffner O; Maor I; Mayseless O; Meir I; Kayam G; Sela-Donenfeld D; Simeone A; Brodski C. 2010. Bmp5/7 in concert with the mid-hindbrain organizer control development of noradrenergic locus coeruleus neurons. Mol Cell Neurosci 45(1):1-11. [PubMed: 20493948]  [MGI Ref ID J:171333]

Myo5ad related

Cattanach BM. 1961. A chemically-induced variegated-type position effect in the mouse. Z Vererbungsl 92:165-82. [PubMed: 13877379]  [MGI Ref ID J:160128]

Coleman DL. 1962. Effect of genic substitution on the incorporation of tyrosine into the melanin of mouse skin. Arch Biochem Biophys 96:562-8. [PubMed: 13880466]  [MGI Ref ID J:12173]

Copeland NG; Hutchison KW; Jenkins NA. 1983. Excision of the DBA ecotropic provirus in dilute coat-color revertants of mice occurs by homologous recombination involving the viral LTRs. Cell 33(2):379-87. [PubMed: 6305507]  [MGI Ref ID J:7092]

Engle LJ; Kennett RH. 1994. Cloning, analysis, and chromosomal localization of myoxin (MYH12), the human homologue to the mouse dilute gene. Genomics 19(3):407-16. [PubMed: 8188282]  [MGI Ref ID J:16915]

Goodwins IR; Vincent MAC. 1955. Further data on linkage between short-ear and Maltese dilution in the house mouse Heredity 9:413-4.  [MGI Ref ID J:259]

Grobman AB; Charles DR. 1947. Mutant white mice. A new dominant autosomal mutant affecting coat color in Mus musculus. J Hered 38:381-384.  [MGI Ref ID J:13058]

Hearing VJ; Phillips P; Lutzner MA. 1973. The fine structure of melanogenesis in coat color mutants of the mouse. J Ultrastruct Res 43(1):88-106. [PubMed: 4634048]  [MGI Ref ID J:5346]

Hutchison KW; Copeland NG; Jenkins NA. 1984. Dilute-coat-color locus of mice: nucleotide sequence analysis of the d+2J and d+Ha revertant alleles. Mol Cell Biol 4(12):2899-904. [PubMed: 6098826]  [MGI Ref ID J:7751]

Jenkins NA; Copeland NG; Taylor BA; Lee BK. 1981. Dilute (d) coat colour mutation of DBA/2J mice is associated with the site of integration of an ecotropic MuLV genome. Nature 293(5831):370-4. [PubMed: 6268990]  [MGI Ref ID J:6587]

Jenkins NA; Copeland NG; Taylor BA; Lee BK. 1982. Organization, distribution, and stability of endogenous ecotropic murine leukemia virus DNA sequences in chromosomes of Mus musculus. J Virol 43(1):26-36. [PubMed: 6287001]  [MGI Ref ID J:6844]

Libby RT; Lillo C; Kitamoto J; Williams DS; Steel KP. 2004. Myosin Va is required for normal photoreceptor synaptic activity. J Cell Sci 117(Pt 19):4509-15. [PubMed: 15316067]  [MGI Ref ID J:92181]

Markert CL; Silvers WK. 1956. The Effects of Genotype and Cell Environment on Melanoblast Differentiation in the House Mouse. Genetics 41(3):429-50. [PubMed: 17247639]  [MGI Ref ID J:12970]

Medical Research Council (MRC) Harwell. 2012. Direct Data Submission 2012/01/05 MGI Direct Data Submission :.  [MGI Ref ID J:178968]

Medical Research Council (MRC) Harwell. 2012. Direct Data Submission 2012/01/18 MGI Direct Data Submission :.  [MGI Ref ID J:179353]

Mercer JA; Seperack PK; Strobel MC; Copeland NG; Jenkins NA. 1991. Novel myosin heavy chain encoded by murine dilute coat colour locus [published erratum appears in Nature 1991 Aug 8;352(6335):547] Nature 349(6311):709-13. [PubMed: 1996138]  [MGI Ref ID J:11005]

Moore KJ; Swing DA; Copeland NG; Jenkins NA. 1990. Interaction of the murine dilute suppressor gene (dsu) with fourteen coat color mutations [published erratum appears in Genetics 1990 Sep;126(1):285] Genetics 125(2):421-30. [PubMed: 2379821]  [MGI Ref ID J:29467]

Moore KJ; Swing DA; Copeland NG; Jenkins NA. 1994. The murine dilute suppressor gene encodes a cell autonomous suppressor. Genetics 138(2):491-7. [PubMed: 7828830]  [MGI Ref ID J:20796]

Moore KJ; Swing DA; Rinchik EM; Mucenski ML; Buchberg AM; Copeland NG; Jenkins NA. 1988. The murine dilute suppressor gene dsu suppresses the coat-color phenotype of three pigment mutations that alter melanocyte morphology, d, ash and ln. Genetics 119(4):933-41. [PubMed: 3410303]  [MGI Ref ID J:9309]

MouseBookTM. 2005. Information obtained from MouseBook<sup>TM</sup>, Medical Research Council Mammalian Genetics Unit, Harwell, UK. Unpublished :.  [MGI Ref ID J:169366]

Murray WS. 1934. The breeding behavior of the dilute brown stock of mice (Little dba) Am J Cancer 20:573-593.  [MGI Ref ID J:2464]

O'Sullivan TN; Wu XS; Rachel RA; Huang JD; Swing DA; Matesic LE; Hammer JA 3rd; Copeland NG; Jenkins NA. 2004. dsu functions in a MYO5A-independent pathway to suppress the coat color of dilute mice. Proc Natl Acad Sci U S A 101(48):16831-6. [PubMed: 15550542]  [MGI Ref ID J:94728]

PIERRO LJ; CHASE HB. 1963. Slate--a new coat color mutant in the mouse. J Hered 54:47-50. [PubMed: 13943454]  [MGI Ref ID J:25388]

Pastural E; Barrat FJ; Dufourcq-Lagelouse R; Certain S; Sanal O ; Jabado N ; Seger R ; Griscelli C ; Fischer A ; de Saint Basile G. 1997. Griscelli disease maps to chromosome 15q21 and is associated with mutations in the myosin-Va gene. Nat Genet 16(3):289-92. [PubMed: 9207796]  [MGI Ref ID J:41253]

Provance DW Jr; Wei M; Ipe V; Mercer JA. 1996. Cultured melanocytes from dilute mutant mice exhibit dendritic morphology and altered melanosome distribution. Proc Natl Acad Sci U S A 93(25):14554-8. [PubMed: 8962090]  [MGI Ref ID J:37976]

Quevedo WC Jr.; Chase HB. 1958. An analysis of the light mutation of coat color in mice. J Morphol 102:329-345.  [MGI Ref ID J:13094]

RIKEN BioResource Center/RIKEN Genomic Sciences Center. 2008. A Large Scale Mutagenesis Program in RIKEN GSC PhenoSITE, World Wide Web (URL: http://www.brc.riken.jp/lab/gsc/mouse/) :.  [MGI Ref ID J:133634]

RUSSELL ES. 1949. A quantitative histological study of the pigment found in the coat-color mutants of the house mouse; interdependence among the variable granule attributes. Genetics 34(2):133-45. [PubMed: 18117146]  [MGI Ref ID J:148461]

Rachel RA; Nagashima K; O'Sullivan TN; Frost LS; Stefano FP; Marigo V; Boesze-Battaglia K. 2012. Melanoregulin, product of the dsu locus, links the BLOC-pathway and OA1 in organelle biogenesis. PLoS One 7(9):e42446. [PubMed: 22984402]  [MGI Ref ID J:191882]

Russell ES. 1948. A Quantitative Histological Study of the Pigment Found in the Coat Color Mutants of the House Mouse. II. Estimates of the Total Volume of Pigment. Genetics 33(3):228-36. [PubMed: 17247280]  [MGI Ref ID J:148462]

Russell ES. 1946. A Quantitative Histological Study of the Pigment Found in the Coat-Color Mutants of the House Mouse. I. Variable Attributes of the Pigment Granules. Genetics 31(3):327-46. [PubMed: 17247200]  [MGI Ref ID J:148463]

Russell ES. 1949. A Quantitative Histological Study of the Pigment Found in the Coat-Color Mutants of the House Mouse. IV. the Nature of the Effects of Genic Substitution in Five Major Allelic Series. Genetics 34(2):146-66. [PubMed: 17247308]  [MGI Ref ID J:12958]

Sweet HO. 1983. Dilute suppressor, a new suppressor gene in the house mouse. J Hered 74(4):305-6. [PubMed: 6886377]  [MGI Ref ID J:7171]

Yoshimura A; Fujii R; Watanabe Y; Okabe S; Fukui K; Takumi T. 2006. Myosin-Va facilitates the accumulation of mRNA/protein complex in dendritic spines. Curr Biol 16(23):2345-51. [PubMed: 17141617]  [MGI Ref ID J:117928]

Rorasg related

Angers M; Uldry M; Kong D; Gimble JM; Jetten AM. 2008. Mfsd2a encodes a novel major facilitator superfamily domain-containing protein highly induced in brown adipose tissue during fasting and adaptive thermogenesis. Biochem J 416(3):347-55. [PubMed: 18694395]  [MGI Ref ID J:143949]

Bahjaoui-Bouhaddi M; Padilla F; Nicolet M; Cifuentes-Diaz C; Fellmann D; Mege RM. 1997. Localized deposition of M-cadherin in the glomeruli of the granular layer during the postnatal development of mouse cerebellum. (Erratum 1997;382:139) J Comp Neurol 378(2):180-95. [PubMed: 9120059]  [MGI Ref ID J:38641]

Bakalian A; Kopmels B; Messer A; Fradelizi D; Delhaye-Bouchaud N; Wollman E; Mariani J. 1992. Peripheral macrophage abnormalities in mutant mice with spinocerebellar degeneration. Res Immunol 143(1):129-39. [PubMed: 1565842]  [MGI Ref ID J:2228]

Baumjohann D; Kageyama R; Clingan JM; Morar MM; Patel S; de Kouchkovsky D; Bannard O; Bluestone JA; Matloubian M; Ansel KM; Jeker LT. 2013. The microRNA cluster miR-17 approximately 92 promotes TFH cell differentiation and represses subset-inappropriate gene expression. Nat Immunol 14(8):840-8. [PubMed: 23812098]  [MGI Ref ID J:205722]

Baurle J; Hoshi M; Grusser-Cornehls U. 1998. Dependence of parvalbumin expression on Purkinje cell input in the deep cerebellar nuclei. J Comp Neurol 392(4):499-514. [PubMed: 9514513]  [MGI Ref ID J:118391]

Bensoula AN; Guastavino JM; Lalonde R; Portet R; Bertin R; Krafft B. 1995. Spatial navigation of staggerer and normal mice during juvenile and adult stages. Physiol Behav 58(5):823-5. [PubMed: 8577876]  [MGI Ref ID J:30012]

Berrebi AS; Morgan JI; Mugnaini E. 1990. The Purkinje cell class may extend beyond the cerebellum. J Neurocytol 19(5):643-54. [PubMed: 2077109]  [MGI Ref ID J:121314]

Besnard S; Bakouche J; Lemaigre-Dubreuil Y; Mariani J; Tedgui A; Henrion D. 2002. Smooth muscle dysfunction in resistance arteries of the staggerer mouse, a mutant of the nuclear receptor RORalpha. Circ Res 90(7):820-5. [PubMed: 11964376]  [MGI Ref ID J:109735]

Besnard S; Silvestre JS; Duriez M; Bakouche J; Lemaigre-Dubreuil Y; Mariani J; Levy BI; Tedgui A. 2001. Increased ischemia-induced angiogenesis in the staggerer mouse, a mutant of the nuclear receptor Roralpha. Circ Res 89(12):1209-15. [PubMed: 11739287]  [MGI Ref ID J:115425]

Blatt GJ; Eisenman LM. 1985. A qualitative and quantitative light microscopic study of the inferior olivary complex in the adult staggerer mutant mouse. J Neurogenet 2(1):51-66. [PubMed: 4020530]  [MGI Ref ID J:7948]

Boufares S; Guastavino JM; Larsson K. 1993. Restoration of staggerer mouse maternal behavior following long-term breeding selection. Physiol Behav 53(6):1151-5. [PubMed: 8346298]  [MGI Ref ID J:14497]

Brugg B; Dubreuil YL; Huber G; Wollman EE; Delhaye-Bouchaud N; Mariani J. 1995. Inflammatory processes induce beta-amyloid precursor protein changes in mouse brain. Proc Natl Acad Sci U S A 92(7):3032. [PubMed: 7708769]  [MGI Ref ID J:24161]

Caston J; Chianale C; Mariani J. 2004. Spatial memory of heterozygous staggerer (Rora(+)/Rora(sg)) versus normal (Rora(+)/Rora(+)) mice during aging. Behav Genet 34(3):319-24. [PubMed: 14990870]  [MGI Ref ID J:101986]

Caston J; Delhaye-Bouchaud N; Mariani J. 1995. Motor behavior of heterozygous staggerer mutant (+/sg) versus normal (+/+) mice during aging. Behav Brain Res 72(1-2):97-102. [PubMed: 8788862]  [MGI Ref ID J:31409]

Caston J; Hilber P; Chianale C; Mariani J. 2003. Effect of training on motor abilities of heterozygous staggerer mutant (Rora(+)/Rora(sg)) mice during aging. Behav Brain Res 141(1):35-42. [PubMed: 12672557]  [MGI Ref ID J:96224]

Chang SH; Reynolds JM; Pappu BP; Chen G; Martinez GJ; Dong C. 2011. Interleukin-17C Promotes Th17 Cell Responses and Autoimmune Disease via Interleukin-17 Receptor E. Immunity 35(4):611-21. [PubMed: 21982598]  [MGI Ref ID J:177650]

Chung Y; Chang SH; Martinez GJ; Yang XO; Nurieva R; Kang HS; Ma L; Watowich SS; Jetten AM; Tian Q; Dong C. 2009. Critical regulation of early Th17 cell differentiation by interleukin-1 signaling. Immunity 30(4):576-87. [PubMed: 19362022]  [MGI Ref ID J:147961]

Costanzo RV; Vila-Ortiz GJ; Perandones C; Carminatti H; Matilla A; Radrizzani M. 2006. Anp32e/Cpd1 regulates protein phosphatase 2A activity at synapses during synaptogenesis. Eur J Neurosci 23(2):309-24. [PubMed: 16420440]  [MGI Ref ID J:105399]

Crepel F; Delhaye-Bouchaud N; Guastavino JM; Sampaio I. 1980. Multiple innervation of cerebellar Purkinje cells by climbing fibres in staggerer mutant mouse. Nature 283(5746):483-4. [PubMed: 7352029]  [MGI Ref ID J:6260]

Deiss V; Baudoin C. 1997. Hyposmia for butanol and vanillin in mutant staggerer male mice. Physiol Behav 61(2):209-13. [PubMed: 9035249]  [MGI Ref ID J:39053]

Deiss V; Baudoin C. 1999. Olfactory learning abilities in staggerer mutant mice. C R Acad Sci III 322(6):467-71. [PubMed: 10457598]  [MGI Ref ID J:58061]

Deiss V; Dubois M; Lalonde R; Strazielle C. 2001. Cytochrome oxidase activity in the olfactory system of staggerer mutant mice. Brain Res 910(1-2):126-33. [PubMed: 11489262]  [MGI Ref ID J:71124]

Deiss V; Feron C; Baudoin C. 1999. Discrimination of olfactory sexual cues in staggerer mutant male mice. Physiol Behav 67(5):631-4. [PubMed: 10604831]  [MGI Ref ID J:96570]

Deiss V; Strazielle C; Lalonde R. 2000. Regional brain variations of cytochrome oxidase activity and motor co-ordination in staggerer mutant mice. Neuroscience 95(3):903-11. [PubMed: 10670457]  [MGI Ref ID J:111971]

Doulazmi M; Frederic F; Capone F; Becker-Andre M; Delhaye-Bouchaud N; Mariani J. 2001. A comparative study of Purkinje cells in two RORalpha gene mutant mice: staggerer and RORalpha(-/-). Brain Res Dev Brain Res 127(2):165-74. [PubMed: 11335003]  [MGI Ref ID J:69287]

Doulazmi M; Frederic F; Lemaigre-Dubreuil Y; Hadj-Sahraoui N ; Delhaye-Bouchaud N ; Mariani J. 1999. Cerebellar Purkinje cell loss during life span of the heterozygous staggerer mouse (Rora(+)/Rora(sg)) is gender-related. J Comp Neurol 411(2):267-73. [PubMed: 10404252]  [MGI Ref ID J:56379]

Duez H; Duhem C; Laitinen S; Patole PS; Abdelkarim M; Bois-Joyeux B; Danan JL; Staels B. 2009. Inhibition of adipocyte differentiation by RORalpha. FEBS Lett 583(12):2031-6. [PubMed: 19450581]  [MGI Ref ID J:150001]

Edelman GM; Chuong CM. 1982. Embryonic to adult conversion of neural cell adhesion molecules in normal and staggerer mice. Proc Natl Acad Sci U S A 79(22):7036-40. [PubMed: 6960362]  [MGI Ref ID J:6930]

Feron C; Baudoin C. 1992. Reactions of Staggerer and Non-Mutant Male Mice to Female Urine and Vaginal Secretion Odors Behav Processes 27(3):165-70.  [MGI Ref ID J:3557]

Feron C; Baudoin C. 1993. Sexual experience and preferences for odors of estrous females in staggerer mutant male mice. Behav Neural Biol 60(3):280-1. [PubMed: 8297325]  [MGI Ref ID J:15645]

Feron C; Baudoin C. 1998. Social isolation induces preference for odours of oestrous females in sexually naive male staggerer mutant mice. Chem Senses 23(1):119-21. [PubMed: 9530977]  [MGI Ref ID J:46472]

Feron C; Baudoin C. 1995. Social isolation partially restores reproduction of male staggerer mutant mice. Physiol Behav 58(1):107-10. [PubMed: 7667406]  [MGI Ref ID J:26698]

Feron C; Baudoin C. 1992. [Reduced influence of penile disability on the mating capacity of male staggerer mice] Reprod Nutr Dev 32(5-6):409-13. [PubMed: 1292478]  [MGI Ref ID J:32193]

Frantz GD; Wuenschell CW; Messer A; Tobin AJ. 1996. Presence of calbindin D28K and GAD67 mRNAs in both orthotopic and ectopic Purkinje cells of staggerer mice suggests that staggerer acts after the onset of cytodifferentiation. J Neurosci Res 44(3):255-62. [PubMed: 8723764]  [MGI Ref ID J:32917]

Furusawa J; Moro K; Motomura Y; Okamoto K; Zhu J; Takayanagi H; Kubo M; Koyasu S. 2013. Critical role of p38 and GATA3 in natural helper cell function. J Immunol 191(4):1818-26. [PubMed: 23851685]  [MGI Ref ID J:205695]

Genoux A; Dehondt H; Helleboid-Chapman A; Duhem C; Hum DW; Martin G; Pennacchio LA; Staels B; Fruchart-Najib J; Fruchart JC. 2005. Transcriptional regulation of apolipoprotein A5 gene expression by the nuclear receptor RORalpha. Arterioscler Thromb Vasc Biol 25(6):1186-92. [PubMed: 15790933]  [MGI Ref ID J:114292]

Gold DA; Baek SH; Schork NJ; Rose DW; Larsen DD; Sachs BD; Rosenfeld MG; Hamilton BA. 2003. RORalpha coordinates reciprocal signaling in cerebellar development through sonic hedgehog and calcium-dependent pathways. Neuron 40(6):1119-31. [PubMed: 14687547]  [MGI Ref ID J:87181]

Gold DA; Gent PM; Hamilton BA. 2007. ROR alpha in genetic control of cerebellum development: 50 staggering years. Brain Res 1140:19-25. [PubMed: 16427031]  [MGI Ref ID J:120622]

Grunwald GB; Eisenman LM. 1993. Analysis of protein variations in adult and postnatal day 11 staggerer and lurcher mutant mice. Brain Res Dev Brain Res 73(1):146-50. [PubMed: 8513552]  [MGI Ref ID J:11841]

Guastavino JM; Larsson K. 1992. The staggerer gene curtails the reproductive life span of females. Behav Genet 22(1):101-12. [PubMed: 1590727]  [MGI Ref ID J:1960]

Guastavino JM; Larsson K; Allain C; Jaisson P. 1993. Neonatal vestibular stimulation and mating in cerebellar mutants. Behav Genet 23(3):265-9. [PubMed: 8352721]  [MGI Ref ID J:14535]

Guo H; Sekiguchi M; Tanaka O; Inoue T; Shima H; Nagao M; Tamura S; Abe H. 1995. Protein phosphatase mRNA expression in Purkinje cells of staggerer and reeler mutant mice. Brain Res Mol Brain Res 33(1):121-6. [PubMed: 8774953]  [MGI Ref ID J:28842]

Hadj-Sahraoui N; Frederic F; Zanjani H; Delhaye-Bouchaud N; Herrup K; Mariani J. 2001. Progressive atrophy of cerebellar Purkinje cell dendrites during aging of the heterozygous staggerer mouse (Rora(+/sg)). Brain Res Dev Brain Res 126(2):201-9. [PubMed: 11248354]  [MGI Ref ID J:68149]

Hadj-Sahraoui N; Frederic F; Zanjani H; Herrup K; Delhaye-Bouchaud N ; Mariani J. 1997. Purkinje cell loss in heterozygous staggerer mutant mice during aging. Brain Res Dev Brain Res 98(1):1-8. [PubMed: 9027398]  [MGI Ref ID J:37701]

Halim TY; Maclaren A; Romanish MT; Gold MJ; McNagny KM; Takei F. 2012. Retinoic-Acid-receptor-related orphan nuclear receptor alpha is required for natural helper cell development and allergic inflammation. Immunity 37(3):463-74. [PubMed: 22981535]  [MGI Ref ID J:187662]

Halim TY; Steer CA; Matha L; Gold MJ; Martinez-Gonzalez I; McNagny KM; McKenzie AN; Takei F. 2014. Group 2 innate lymphoid cells are critical for the initiation of adaptive T helper 2 cell-mediated allergic lung inflammation. Immunity 40(3):425-35. [PubMed: 24613091]  [MGI Ref ID J:210240]

Hamilton BA; Frankel WN; Kerrebrock AW; Hawkins TL; FitzHugh W; Kusumi K; Russell LB; Mueller KL; van Berkel V; Birren BW; Kruglyak L; Lander ES. 1996. Disruption of the nuclear hormone receptor RORalpha in staggerer mice. Nature 379(6567):736-9. [PubMed: 8602221]  [MGI Ref ID J:31470]

Hams E; Armstrong ME; Barlow JL; Saunders SP; Schwartz C; Cooke G; Fahy RJ; Crotty TB; Hirani N; Flynn RJ; Voehringer D; McKenzie AN; Donnelly SC; Fallon PG. 2014. IL-25 and type 2 innate lymphoid cells induce pulmonary fibrosis. Proc Natl Acad Sci U S A 111(1):367-72. [PubMed: 24344271]  [MGI Ref ID J:206290]

Hatten ME; Messer A. 1978. Postnatal cerebellar cells from staggerer mutant mice express embryonic cell surface characteristic. Nature 276(5687):504-6. [PubMed: 723931]  [MGI Ref ID J:6068]

Herrup K. 1983. Role of staggerer gene in determining cell number in cerebellar cortex. I. Granule cell death is an indirect consequence of staggerer gene action. Brain Res 313(2):267-74. [PubMed: 6667376]  [MGI Ref ID J:28093]

Herrup K; Mullen RJ. 1979. Regional variation and absence of large neurons in the cerebellum of the staggerer mouse. Brain Res 172(1):1-12. [PubMed: 466453]  [MGI Ref ID J:6185]

Herrup K; Mullen RJ. 1979. Staggerer chimeras: intrinsic nature of Purkinje cell defects and implications for normal cerebellar development. Brain Res 178(2-3):443-57. [PubMed: 509213]  [MGI Ref ID J:11945]

Heuze P; Feron C; Baudoin C. 1997. Early behavioral development of mice is affected by staggerer mutation as soon as postnatal day three. Brain Res Dev Brain Res 101(1-2):81-4. [PubMed: 9263582]  [MGI Ref ID J:42144]

Ikeda M; Matsui K; Ishihara Y; Morita I; Murota S; Yuasa T; Miyatake T. 1994. Cerebellar nitric oxide synthase, cGMP and motor function in two lines of cerebellar mutant mice, Staggerer and Wriggle Mouse Sagami. Neurosci Lett 168(1-2):65-8. [PubMed: 7518067]  [MGI Ref ID J:18352]

Jaradat M; Stapleton C; Tilley SL; Dixon D; Erikson CJ; McCaskill JG; Kang HS; Angers M; Liao G; Collins J; Grissom S; Jetten AM. 2006. Modulatory role for retinoid-related orphan receptor alpha in allergen-induced lung inflammation. Am J Respir Crit Care Med 174(12):1299-309. [PubMed: 16973978]  [MGI Ref ID J:135863]

Jarvis CI; Staels B; Brugg B; Lemaigre-Dubreuil Y; Tedgui A; Mariani J. 2002. Age-related phenotypes in the staggerer mouse expand the RORalpha nuclear receptor's role beyond the cerebellum. Mol Cell Endocrinol 186(1):1-5. [PubMed: 11850116]  [MGI Ref ID J:75570]

Ji Z; Jin Q; Vogel MW. 1997. Evidence of spinocerebellar mossy fiber segregation in the juvenile staggerer cerebellum. J Comp Neurol 378(3):354-62. [PubMed: 9034896]  [MGI Ref ID J:38768]

Jin P; Sun Y; Grabowski GA. 2001. In vivo roles of RORalpha and Sp4 in the regulation of murine prosaposin gene. DNA Cell Biol 20(12):781-9. [PubMed: 11879571]  [MGI Ref ID J:74710]

Jorgensen OS. 1994. Neural cell adhesion molecule and D3 protein in the cerebellum of weaver mutant mice. Int J Dev Neurosci 12(3):213-25. [PubMed: 7942094]  [MGI Ref ID J:19350]

Journiac N; Jolly S; Jarvis C; Gautheron V; Rogard M; Trembleau A; Blondeau JP; Mariani J; Vernet-der Garabedian B. 2009. The nuclear receptor ROR(alpha) exerts a bi-directional regulation of IL-6 in resting and reactive astrocytes. Proc Natl Acad Sci U S A 106(50):21365-70. [PubMed: 19955433]  [MGI Ref ID J:155827]

Kang HS; Angers M; Beak JY; Wu X; Gimble JM; Wada T; Xie W; Collins JB; Grissom SF; Jetten AM. 2007. Gene expression profiling reveals a regulatory role for ROR alpha and ROR gamma in phase I and phase II metabolism. Physiol Genomics 31(2):281-94. [PubMed: 17666523]  [MGI Ref ID J:207076]

Kang HS; Okamoto K; Takeda Y; Beak JY; Gerrish K; Bortner CD; Degraff LM; Wada T; Xie W; Jetten AM. 2011. Transcriptional profiling reveals a role for ROR{alpha} in regulating gene expression in obesity-associated inflammation and hepatic steatosis. Physiol Genomics 43(13):818-28. [PubMed: 21540300]  [MGI Ref ID J:174804]

Kopmels B; Mariani J; Delhaye-Bouchaud N; Audibert F; Fradelizi D; Wollman EE. 1992. Evidence for a hyperexcitability state of staggerer mutant mice macrophages. J Neurochem 58(1):192-9. [PubMed: 1727430]  [MGI Ref ID J:28096]

Kopmels B; Mariani J; Taupin V; Delhaye-Bouchaud N; Wollman EE. 1991. Differential IL-6 mRNA expression by stimulated peripheral macrophages of Staggerer and Lurcher cerebellar mutant mice. Eur Cytokine Netw 2(5):345-53. [PubMed: 1804324]  [MGI Ref ID J:11652]

Kopmels B; Wollman EE; Guastavino JM; Delhaye-Bouchaud N; Fradelizi D; Mariani J. 1990. Interleukin-1 hyperproduction by in vitro activated peripheral macrophages from cerebellar mutant mice. J Neurochem 55(6):1980-5. [PubMed: 2230805]  [MGI Ref ID J:28095]

Lalonde R; Bensoula AN; Filali M. 1995. Rotorod sensorimotor learning in cerebellar mutant mice. Neurosci Res 22(4):423-6. [PubMed: 7478307]  [MGI Ref ID J:28880]

Lalonde R; Filali M; Bensoula AN; Lestienne F. 1996. Sensorimotor learning in three cerebellar mutant mice. Neurobiol Learn Mem 65(2):113-20. [PubMed: 8833100]  [MGI Ref ID J:31867]

Lalonde R; Filali M; Bensoula AN; Monnier C; Guastavino JM. 1996. Spatial learning in a Z-maze by cerebellar mutant mice. Physiol Behav 59(1):83-6. [PubMed: 8848495]  [MGI Ref ID J:30686]

Lalonde R; Strazielle C. 2008. Discrimination learning in Rora(sg) and Grid2(ho) mutant mice. Neurobiol Learn Mem 90(2):472-4. [PubMed: 18583162]  [MGI Ref ID J:154430]

Lalonde R; Strazielle C. 2007. Spontaneous and induced mouse mutations with cerebellar dysfunctions: behavior and neurochemistry. Brain Res 1140:51-74. [PubMed: 16499884]  [MGI Ref ID J:120621]

Landis DM; Sidman RL. 1978. Electron microscopic analysis of postnatal histogenesis in the cerebellar cortex of staggerer mutant mice. J Comp Neurol 179(4):831-63. [PubMed: 641237]  [MGI Ref ID J:5968]

Lau P; Fitzsimmons RL; Pearen MA; Watt MJ; Muscat GE. 2011. Homozygous staggerer (sg/sg) mice display improved insulin sensitivity and enhanced glucose uptake in skeletal muscle. Diabetologia :. [PubMed: 21279323]  [MGI Ref ID J:168538]

Lau P; Fitzsimmons RL; Raichur S; Wang SC; Lechtken A; Muscat GE. 2008. The orphan nuclear receptor, RORalpha, regulates gene expression that controls lipid metabolism: staggerer (SG/SG) mice are resistant to diet-induced obesity. J Biol Chem 283(26):18411-21. [PubMed: 18441015]  [MGI Ref ID J:138180]

Lemaigre-Dubreuil Y; Brugg B; Chianale C; Delhaye-Bouchaud N; Mariani J. 1996. Over-expression of interleukin-1 beta-converting enzyme mRNA in staggerer cerebellum. Neuroreport 7(11):1777-80. [PubMed: 8905663]  [MGI Ref ID J:36680]

Luntz-Leybman V; Rotter A; Zdilar D; Frostholm A. 1995. Uncoupling of GABAA/benzodiazepine receptor alpha 1, beta 2, and gamma 2 subunit mRNA expression in cerebellar Purkinje cells of staggerer mutant mice. J Neurosci 15(12):8121-30. [PubMed: 8613747]  [MGI Ref ID J:30353]

Mallet J; Huchet M; Pougeois R; Changeux JP. 1976. Anatomical, physiological and biochemical studies on the cerebellum from mutant mice. III. Protein differences associated with the weaver, staggerer and nervous mutations. Brain Res 103(2):291-312. [PubMed: 1252920]  [MGI Ref ID J:5619]

Mamontova A; Seguret-Mace S; Esposito B; Chaniale C; Bouly M; Delhaye-Bouchaud N; Luc G; Staels B; Duverger N; Mariani J; Tedgui A. 1998. Severe atherosclerosis and hypoalphalipoproteinemia in the staggerer mouse, a mutant of the nuclear receptor RORalpha. Circulation 98(24):2738-43. [PubMed: 9851961]  [MGI Ref ID J:52105]

Matsui K; Itoh K; Mizumachi M; Kubo H; Goto T; Sato S; Wada K. 1996. Effect of intranasal administration of thyrotropin-releasing hormone on ataxic gait in staggerer mice. Neurosci Lett 212(2):115-8. [PubMed: 8832652]  [MGI Ref ID J:35010]

Matsui K; Kato N; Watanabe N; Ando K. 1988. [Elevated immunoreactive-somatostatin levels in the brain of ataxic mutant mice] Jikken Dobutsu 37(3):263-8. [PubMed: 2901364]  [MGI Ref ID J:28478]

Matsui K; Wada K; Kwak S. 1994. Ataxia-ameliorating effects of YM-14673, a potent analog of thyrotropin releasing hormone, in ataxic mutant mice. Eur J Pharmacol 254(3):295-7. [PubMed: 8013566]  [MGI Ref ID J:18435]

Matysiak-Scholze U; Nehls M. 1997. The structural integrity of ROR alpha isoforms is mutated in staggerer mice: cerebellar coexpression of ROR alpha1 and ROR alpha4. Genomics 43(1):78-84. [PubMed: 9226375]  [MGI Ref ID J:41653]

McHedlidze T; Waldner M; Zopf S; Walker J; Rankin AL; Schuchmann M; Voehringer D; McKenzie AN; Neurath MF; Pflanz S; Wirtz S. 2013. Interleukin-33-dependent innate lymphoid cells mediate hepatic fibrosis. Immunity 39(2):357-71. [PubMed: 23954132]  [MGI Ref ID J:208227]

Messer A; Plummer-Siegard J; Eisenberg B. 1990. Staggerer mutant mouse Purkinje cells do not contain detectable calmodulin mRNA. J Neurochem 55(1):293-302. [PubMed: 2355223]  [MGI Ref ID J:28469]

Michel V; Monnier Z; Guastavino JM; Propper A; Math F. 2000. Functional alterations in the olfactory bulb of the staggerer mutant mouse. Neurosci Lett 280(1):1-4. [PubMed: 10696797]  [MGI Ref ID J:107925]

Miret-Duvaux O; Frederic F; Simon D; Guenet JL; Hanauer A; Delhaye-Bouchaud N; Mariani J. 1990. Glutamate dehydrogenase in cerebellar mutant mice: gene localization and enzyme activity in different tissues. J Neurochem 54(1):23-9. [PubMed: 2293612]  [MGI Ref ID J:10148]

Mitsuma T; Adachi K; Mukoyama M; Ando K. 1990. Pro-thyrotropin-releasing hormone concentrations in the brain of ataxic mice. J Neurol Sci 98(2-3):163-7. [PubMed: 2123001]  [MGI Ref ID J:28467]

Mitsumura K; Hosoi N; Furuya N; Hirai H. 2011. Disruption of metabotropic glutamate receptor signalling is a major defect at cerebellar parallel fibre-Purkinje cell synapses in staggerer mutant mice. J Physiol 589(Pt 13):3191-209. [PubMed: 21558162]  [MGI Ref ID J:189405]

Monnier Z; Bahjaoui-Bouhaddi M; Bride J; Bride M; Math F; Propper A. 1999. Structural and immunohistological modifications in olfactory bulb of the staggerer mutant mouse. Biol Cell 91(1):29-44. [PubMed: 10321020]  [MGI Ref ID J:55239]

Muramoto O; Ando K; Kanazawa I. 1982. Central noradrenaline metabolism in cerebellar ataxic mice. Brain Res 237(2):387-95. [PubMed: 6123371]  [MGI Ref ID J:164122]

Murase S; Hayashi Y. 1998. Expression pattern and neurotrophic role of the c-fms proto-oncogene M-CSF receptor in rodent Purkinje cells. J Neurosci 18(24):10481-92. [PubMed: 9852586]  [MGI Ref ID J:52174]

Murase S; Hayashi Y. 1996. Expression pattern of integrin beta 1 subunit in Purkinje cells of rat and cerebellar mutant mice. J Comp Neurol 375(2):225-37. [PubMed: 8915827]  [MGI Ref ID J:36459]

Nakagawa S; Watanabe M; Inoue Y. 1996. Altered gene expression of the N-methyl-D-aspartate receptor channel subunits in Purkinje cells of the staggerer mutant mouse. Eur J Neurosci 8(12):2644-51. [PubMed: 8996814]  [MGI Ref ID J:39065]

Nakagawa S; Watanabe M; Inoue Y. 1996. Regional variation in expression of calbindin and inositol 1,4,5-trisphosphate receptor type 1 mRNAs in the cerebellum of the staggerer mutant mouse. Eur J Neurosci 8(7):1401-7. [PubMed: 8758947]  [MGI Ref ID J:35712]

Nakagawa S; Watanabe M; Isobe T; Kondo H; Inoue Y. 1998. Cytological compartmentalization in the staggerer cerebellum, as revealed by calbindin immunohistochemistry for Purkinje cells. J Comp Neurol 395(1):112-20. [PubMed: 9590549]  [MGI Ref ID J:47380]

Nurieva RI; Chung Y; Hwang D; Yang XO; Kang HS; Ma L; Wang YH; Watowich SS; Jetten AM; Tian Q; Dong C. 2008. Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages. Immunity 29(1):138-49. [PubMed: 18599325]  [MGI Ref ID J:137869]

Okamoto K; Iwai Y; Oh-Hora M; Yamamoto M; Morio T; Aoki K; Ohya K; Jetten AM; Akira S; Muta T; Takayanagi H. 2010. IkappaBzeta regulates T(H)17 development by cooperating with ROR nuclear receptors. Nature 464(7293):1381-5. [PubMed: 20383124]  [MGI Ref ID J:159461]

Perandones C; Costanzo RV; Kowaljow V; Pivetta OH; Carminatti H; Radrizzani M. 2004. Correlation between synaptogenesis and the PTEN phosphatase expression in dendrites during postnatal brain development. Brain Res Mol Brain Res 128(1):8-19. [PubMed: 15337313]  [MGI Ref ID J:92848]

Qiu CH; Shimokawa N; Iwasaki T; Parhar IS; Koibuchi N. 2007. Alteration of cerebellar neurotropin messenger ribonucleic acids and the lack of thyroid hormone receptor augmentation by staggerer-type retinoic acid receptor-related orphan receptor-alpha mutation. Endocrinology 148(4):1745-53. [PubMed: 17218417]  [MGI Ref ID J:129580]

Radrizzani M; Carminatti H; Pivetta OH; Idoyaga Vargas VP. 1995. Developmental regulation of Thy 1.2 rate of synthesis in the mouse cerebellum. J Neurosci Res 42(2):220-7. [PubMed: 8568922]  [MGI Ref ID J:29491]

Raspe E; Duez H; Gervois P; Fievet C; Fruchart JC; Besnard S; Mariani J; Tedgui A; Staels B. 2001. Transcriptional regulation of apolipoprotein C-III gene expression by the orphan nuclear receptor RORalpha. J Biol Chem 276(4):2865-71. [PubMed: 11053433]  [MGI Ref ID J:124837]

Roffler-Tarlov S; Herrup K. 1981. Quantitative examination of the deep cerebellar nuclei in the staggerer mutant mouse. Brain Res 215(1-2):49-59. [PubMed: 7260600]  [MGI Ref ID J:6554]

Roffler-Tarlov S; Turey M. 1982. The content of amino acids in the developing cerebellar cortex and deep cerebellar nuclei of granule cell deficient mutant mice. Brain Res 247(1):65-73. [PubMed: 6127146]  [MGI Ref ID J:6875]

Ryo Y; Miyawaki A; Furuichi T; Mikoshiba K. 1993. Expression of the metabotropic glutamate receptor mGluR1 alpha and the ionotropic glutamate receptor GluR1 in the brain during the postnatal development of normal mouse and in the cerebellum from mutant mice. J Neurosci Res 36(1):19-32. [PubMed: 8230318]  [MGI Ref ID J:14425]

SIDMAN RL; LANE PW; DICKIE MM. 1962. Staggerer, a new mutation in the mouse affecting the cerebellum. Science 137:610-2. [PubMed: 13912552]  [MGI Ref ID J:13140]

Saito T; Hirano M; Ide T; Ichiki T; Koibuchi N; Sunagawa K; Hirano K. 2013. Pivotal role of Rho-associated kinase 2 in generating the intrinsic circadian rhythm of vascular contractility. Circulation 127(1):104-14. [PubMed: 23172836]  [MGI Ref ID J:209475]

Schaal H; Wille C; Wille W. 1985. Changes of ganglioside pattern during cerebellar development of normal and staggerer mice. J Neurochem 45(2):544-51. [PubMed: 4009175]  [MGI Ref ID J:7910]

Serinagaoglu Y; Zhang R; Zhang Y; Zhang L; Hartt G; Young AP; Oberdick J. 2007. A promoter element with enhancer properties, and the orphan nuclear receptor RORalpha, are required for Purkinje cell-specific expression of a Gi/o modulator. Mol Cell Neurosci 34(3):324-42. [PubMed: 17215137]  [MGI Ref ID J:123239]

Serra HG; Duvick L; Zu T; Carlson K; Stevens S; Jorgensen N; Lysholm A; Burright E; Zoghbi HY; Clark HB; Andresen JM; Orr HT. 2006. RORalpha-mediated Purkinje cell development determines disease severity in adult SCA1 mice. Cell 127(4):697-708. [PubMed: 17110330]  [MGI Ref ID J:116123]

Shirley LT; Messer A. 2004. Early postnatal Purkinje cells from staggerer mice undergo aberrant development in vitro with characteristic morphologic and gene expression abnormalities. Brain Res Dev Brain Res 152(2):153-7. [PubMed: 15351503]  [MGI Ref ID J:109172]

Soha JM; Herrup K. 1993. Purkinje cell dendrites in staggerer<-->wild type mouse chimeras lack the aberrant morphologies found in lurcher<-->wild type chimeras. J Comp Neurol 331(4):540-50. [PubMed: 8509510]  [MGI Ref ID J:12149]

Soha JM; Herrup K. 1995. Stunted morphologies of cerebellar Purkinje cells in lurcher and staggerer mice are cell-intrinsic effects of the mutant genes. J Comp Neurol 357(1):65-75. [PubMed: 7673468]  [MGI Ref ID J:26094]

Soha JM; Kim S; Crandall JE; Vogel MW. 1997. Rapid growth of parallel fibers in the cerebella of normal and staggerer mutant mice. J Comp Neurol 389(4):642-54. [PubMed: 9421144]  [MGI Ref ID J:44432]

Sonmez E; Herrup K. 1984. Role of staggerer gene in determining cell number in cerebellar cortex. II. Granule cell death and persistence of the external granule cell layer in young mouse chimeras. Brain Res 314(2):271-83. [PubMed: 6704753]  [MGI Ref ID J:28092]

Sotelo C. 1990. Cerebellar synaptogenesis: what we can learn from mutant mice. J Exp Biol 153:225-49. [PubMed: 2280222]  [MGI Ref ID J:10974]

Stapleton CM; Jaradat M; Dixon D; Kang HS; Kim SC; Liao G; Carey MA; Cristiano J; Moorman MP; Jetten AM. 2005. Enhanced susceptibility of staggerer (RORalphasg/sg) mice to lipopolysaccharide-induced lung inflammation. Am J Physiol Lung Cell Mol Physiol 289(1):L144-52. [PubMed: 15778248]  [MGI Ref ID J:104750]

Steinmayr M; Andre E; Conquet F; Rondi-Reig L; Delhaye-Bouchaud N ; Auclair N ; Daniel H ; Crepel F ; Mariani J ; Sotelo C ; Becker-Andre M. 1998. staggerer phenotype in retinoid-related orphan receptor alpha-deficient mice. Proc Natl Acad Sci U S A 95(7):3960-5. [PubMed: 9520475]  [MGI Ref ID J:46854]

Swanson DJ; Steshina EY; Wakenight P; Aldinger KA; Goldowitz D; Millen KJ; Chizhikov VV. 2010. Phenotypic and genetic analysis of the cerebellar mutant tmgc26, a new ENU-induced ROR-alpha allele. Eur J Neurosci 32(5):707-16. [PubMed: 20722722]  [MGI Ref ID J:171777]

Takeda Y; Jothi R; Birault V; Jetten AM. 2012. RORgamma directly regulates the circadian expression of clock genes and downstream targets in vivo. Nucleic Acids Res 40(17):8519-35. [PubMed: 22753030]  [MGI Ref ID J:199687]

Takeda Y; Kang HS; Angers M; Jetten AM. 2011. Retinoic acid-related orphan receptor {gamma} directly regulates neuronal PAS domain protein 2 transcription in vivo. Nucleic Acids Res 39(11):4769-82. [PubMed: 21317191]  [MGI Ref ID J:173696]

Trenkner E. 1979. Postnatal cerebellar cells of staggerer mutant mice express immature components on their surface. Nature 277(5697):566-7. [PubMed: 368650]  [MGI Ref ID J:6088]

Triarhou LC; Low WC; Ghetti B. 1987. Transplantation of cerebellar anlagen to hosts with genetic cerebellocortical atrophy. Anat Embryol (Berl) 176(2):145-54. [PubMed: 3619071]  [MGI Ref ID J:28471]

Tuong ZK; Lau P; Yeo JC; Pearen MA; Wall AA; Stanley AC; Stow JL; Muscat GE. 2013. Disruption of Roralpha1 and cholesterol 25-hydroxylase expression attenuates phagocytosis in male Roralphasg/sg mice. Endocrinology 154(1):140-9. [PubMed: 23239817]  [MGI Ref ID J:194611]

Vandunk C; Hunter LA; Gray PA. 2011. Development, maturation, and necessity of transcription factors in the mouse suprachiasmatic nucleus. J Neurosci 31(17):6457-67. [PubMed: 21525287]  [MGI Ref ID J:171421]

Varecka L; Wu CH; Rotter A; Frostholm A. 1994. GABAA/benzodiazepine receptor alpha 6 subunit mRNA in granule cells of the cerebellar cortex and cochlear nuclei: expression in developing and mutant mice. J Comp Neurol 339(3):341-52. [PubMed: 8132866]  [MGI Ref ID J:16213]

Vernet-der Garabedian B; Lemaigre-Dubreuil Y; Delhaye-Bouchaud N ; Mariani J. 1998. Abnormal IL-1beta cytokine expression in the cerebellum of the ataxic mutant mice staggerer and lurcher. Brain Res Mol Brain Res 62(2):224-7. [PubMed: 9813341]  [MGI Ref ID J:51056]

Vogel MW; Sinclair M; Qiu D; Fan H. 2000. Purkinje cell fate in staggerer mutants: agenesis versus cell death. J Neurobiol 42(3):323-37. [PubMed: 10645972]  [MGI Ref ID J:113250]

Wong SH; Walker JA; Jolin HE; Drynan LF; Hams E; Camelo A; Barlow JL; Neill DR; Panova V; Koch U; Radtke F; Hardman CS; Hwang YY; Fallon PG; McKenzie AN. 2012. Transcription factor RORalpha is critical for nuocyte development. Nat Immunol 13(3):229-36. [PubMed: 22267218]  [MGI Ref ID J:181284]

Yamazaki T; Yang XO; Chung Y; Fukunaga A; Nurieva R; Pappu B; Martin-Orozco N; Kang HS; Ma L; Panopoulos AD; Craig S; Watowich SS; Jetten AM; Tian Q; Dong C. 2008. CCR6 regulates the migration of inflammatory and regulatory T cells. J Immunol 181(12):8391-401. [PubMed: 19050256]  [MGI Ref ID J:142071]

Yang XO; Nurieva R; Martinez GJ; Kang HS; Chung Y; Pappu BP; Shah B; Chang SH; Schluns KS; Watowich SS; Feng XH; Jetten AM; Dong C. 2008. Molecular antagonism and plasticity of regulatory and inflammatory T cell programs. Immunity 29(1):44-56. [PubMed: 18585065]  [MGI Ref ID J:137851]

Yang XO; Pappu BP; Nurieva R; Akimzhanov A; Kang HS; Chung Y; Ma L; Shah B; Panopoulos AD; Schluns KS; Watowich SS; Tian Q; Jetten AM; Dong C. 2008. T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma. Immunity 28(1):29-39. [PubMed: 18164222]  [MGI Ref ID J:131020]

Yoon CH. 1972. Developmental mechanism for changes in cerebellum of staggerer mouse, a neurological mutant of genetic origin. Neurology 22(7):743-54. [PubMed: 4673255]  [MGI Ref ID J:5304]

Zanjani HS; Herrup K; Guastavino JM; Delhaye-Bouchaud N; Mariani J. 1994. Developmental studies of the inferior olivary nucleus in staggerer mutant mice. Brain Res Dev Brain Res 82(1-2):18-28. [PubMed: 7842506]  [MGI Ref ID J:20982]

Zanjani HS; Mariani J; Delhaye-Bouchaud N; Herrup K. 1992. Neuronal cell loss in heterozygous staggerer mutant mice: a model for genetic contributions to the aging process. Brain Res Dev Brain Res 67(2):153-60. [PubMed: 1511513]  [MGI Ref ID J:1431]

Zanjani HS; Mariani J; Herrup K. 1990. Cell loss in the inferior olive of the staggerer mutant mouse is an indirect effect of the gene. J Neurogenet 6(4):229-41. [PubMed: 2231177]  [MGI Ref ID J:28468]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $3300.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery of Strains Needing Progeny Testing
    At least two untested males and two untested females (two pairs) will be recovered (eight or more mice is typical). The total number of animals provided, their gender and genotype will vary. Untested animals typically are available to ship between 10 and 14 weeks from the date of your order. If the first recovery attempt is unsuccessful, a second recovery will be done, extending the overall recovery time to approximately 25 weeks. Progeny testing is required to identify the genotype of mice of this strain, as a genotyping assay is not available. This type of testing involves breeding the recovered animals and assessing the phenotype of the offspring in order to identify animals carrying the mutation of interest. We can perform the progeny testing for you as a service or we can ship all recovered animals to you for progeny testing at your facility. If you perform the progeny testing, there is no guarantee that a carrier will be identified. If we perform progeny testing as a service, additional breeding time will be required. In this case, when a male and female (one pair) are identified that carry the mutation, they and their offspring will be shipped. Delivery time for strains requiring progeny testing often exceeds 25 weeks and may take 12 months or more due to the difficulties in breeding some strains. The progeny testing cost is in addition to the recovery cost and is based on the number of boxes used and the time taken to produce the mice identified as carrying the mutation.
    Please note that identified pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation.

    Please contact Customer Service for more information on the cost of progeny testing for a strain, tel: 1-800-422-6423 or 1-207-288-5845 (from any location). The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
    Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $4290.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery of Strains Needing Progeny Testing
    At least two untested males and two untested females (two pairs) will be recovered (eight or more mice is typical). The total number of animals provided, their gender and genotype will vary. Untested animals typically are available to ship between 10 and 14 weeks from the date of your order. If the first recovery attempt is unsuccessful, a second recovery will be done, extending the overall recovery time to approximately 25 weeks. Progeny testing is required to identify the genotype of mice of this strain, as a genotyping assay is not available. This type of testing involves breeding the recovered animals and assessing the phenotype of the offspring in order to identify animals carrying the mutation of interest. We can perform the progeny testing for you as a service or we can ship all recovered animals to you for progeny testing at your facility. If you perform the progeny testing, there is no guarantee that a carrier will be identified. If we perform progeny testing as a service, additional breeding time will be required. In this case, when a male and female (one pair) are identified that carry the mutation, they and their offspring will be shipped. Delivery time for strains requiring progeny testing often exceeds 25 weeks and may take 12 months or more due to the difficulties in breeding some strains. The progeny testing cost is in addition to the recovery cost and is based on the number of boxes used and the time taken to produce the mice identified as carrying the mutation.
    Please note that identified pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation.

    Please contact Customer Service for more information on the cost of progeny testing for a strain, tel: 1-800-422-6423 or 1-207-288-5845 (from any location). The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
    Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Control Information

  Control
   Untyped from the colony
   000664 C57BL/6J
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.


See Terms of Use tab for General Terms and Conditions


The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
Ordering Information
JAX® Mice
Surgical and Preconditioning Services
JAX® Services
Customer Services and Support
Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
Technical Support Email Form

Terms of Use

Terms of Use


General Terms and Conditions


Contact information

General inquiries regarding Terms of Use

Contracts Administration

phone:207-288-6470

JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


(6.8)