Strain Name:

B6CBACa Aw-J/A-Plp1jp EdaTa/J

Stock Number:

000287

Order this mouse

Availability:

Cryopreserved - Ready for recovery

Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Former Names B6CBACa Aw-J/A-Plpjp EdaTa/J    (Changed: 05-JAN-05 )
B6CBACa-Aw-J/A-EdaTa Plpjp    (Changed: 15-DEC-04 )
B6CBACa-Aw-J/A-Plpjp EdaTa    (Changed: 15-DEC-04 )
Type Mutant Strain;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Mating SystemTJL Breeding Scheme: progeny test; heterozygote x F1 TJL Breeding Summary: Ta ?/+ + female x B6CBACa-Aw-J F1 male. Females which yield Plpjp/Y males become proven Ta Plpjp/+ + breeders for colony maintenance.
Specieslaboratory mouse
GenerationN59p
Generation Definitions

Appearance
white-bellied agouti, tremors
Related Genotype: Aw-J/A Plp1jp/Y

white-bellied agouti, unaffected
Related Genotype: Aw-J/A +/Y or +/?

agouti, tremors
Related Genotype: A/A Plp1jp/Y

agouti, unaffected
Related Genotype: A/A +/Y or +/?

Important Note
This strain is heterozygous for Plp1jp and EdaTa maintained on the same X chromosome.

Description
Hemizygous males carrying the X-linked jimpy spontaneous mutation (Plp1jp) appear normal when sitting quietly, but beginning at about 3 weeks of age they show a marked tremor of the hindquarters when attempting movement. After 3 weeks of age convulsions may occur. These males die between 20 and 40 days of age. In males, the CNS is very deficient in myelin, but the PNS is normally myelinated. Heterozygous jimpy females have normal lifespans with no overt phenotype. However, jimpy heterozygous females are reported to have reduced numbers of oligodendrocytes compared to wildtype females. While the mutation is recessive, only partial phenotypic rescue was attained by the transgenic expression of the two major isoforms, PLP and DM20, suggesting a dominant negative action from this allele (Nandon et al., 1994). This stock is also carrying the X-linked tabby mutation (EdaTa).

Development
The tabby (EdaTa) and jimpy (Plp1jp) mutations were imported to The Jackson Laboratory together from Dr. Mary Lyon at Harwell in 1961. Tabby had arisen spontaneously in a strain selected for large size (Falconer DS 1953. Z Indukt Abstammungs-Vererbungsl 85:210-19) and jimpy arose in an inbred line (Philips RJS. 1954. Z Indukt Abstammungs Vererbungsl 86:322-6) in 1954. The imported stock was segregating for other loci but tabby and jimpy, linked and located on the X Chromosome, were maintained by sibling matings generally of the EdaTa Plp1jp/+ + genotype crossed to a Ta/Y or +/Y male. In 1965 at approximately generation F6 a EdaTa Plp1jp/+ + female was outcrossed to a C57BL/6J-Aw-J male and pairs were mated. At F3 a EdaTa Plp1jp/+ + female was again crossed to a C57BL/6J-Aw-J male. The stock was then continually backcrossed into the C57BL/6J-Aw-J strain to N10. At N11 a cross of a EdaTa Plp1jp/+ + female was made to a CBA/Ca male and in the next generation a EdaTa Plp1jp/+ + female was crossed to the B6CBACa F1 hybrid male and the stock was then bred by crossing to the hybrid male each generation. It was cryopreserved in 1981 by mating EdaTa Plp1jp-?/+ + females at N71 to B6CBACa-Aw-J/A F1 males.

Control Information

  Control
   Untyped from the colony
 
  Considerations for Choosing Controls

Related Strains

View Strains carrying   Aw-J     (30 strains)

Strains carrying   EdaTa allele
000314   B6CBACa Aw-J/A-EdaTa/J-XO
000569   C57BL/6J-Aw-J-EdaTa +/+ ArTfm/J
000583   STOCK T(X;16)16H +/+ EdaTa
View Strains carrying   EdaTa     (3 strains)

View Strains carrying other alleles of Eda     (8 strains)

Strains carrying other alleles of Plp1
005975   B6.Cg-Tg(Plp1-cre/ERT)3Pop/J
003255   B6;129-Plp1tm1Kan/J
024701   D2.Cg-Tg(Plp1-cre/ERT)3Pop/SjJ
View Strains carrying other alleles of Plp1     (3 strains)

Strains carrying other alleles of a
002655   Mus pahari/EiJ
000251   AEJ.Cg-ae +/a Gdf5bp-H/J
000202   AEJ/Gn-bd/J
000199   AEJ/GnLeJ
000433   B10.C-H3c H13? A/(28NX)SnJ
000427   B10.CE-H13b Aw/(30NX)SnJ
000423   B10.KR-H13? A/SnJ
000420   B10.LP-H13b Aw/Sn
000477   B10.PA-Bloc1s6pa H3e at/SnJ
000419   B10.UW-H3b we Pax1un at/SnJ
003879   B10;TFLe-a/a T Itpr3tf/+ Itpr3tf/J
001538   B6 x B6C3Sn a/A-T(1;9)27H/J
000916   B6 x B6C3Sn a/A-T(5;12)31H/J
000602   B6 x B6C3Sn a/A-T(8;16)17H/J
002083   B6 x B6EiC3 a/A-T(7;16)235Dn/J
000507   B6 x B6EiC3 a/A-Otcspf/J
003759   B6 x B6EiC3Sn a/A-T(10;16)232Dn/J
002071   B6 x B6EiC3Sn a/A-T(11;17)202Dn/J
002113   B6 x B6EiC3Sn a/A-T(11A2;16B3)238Dn/J
002068   B6 x B6EiC3Sn a/A-T(11B1;16B5)233Dn/J
002069   B6 x B6EiC3Sn a/A-T(14E4or5;16B5)225Dn/J
001926   B6 x B6EiC3Sn a/A-T(15;16)198Dn/J
001832   B6 x B6EiC3Sn a/A-T(15E;16B1)60Dn/J
003758   B6 x B6EiC3Sn a/A-T(16C3-4;17A2)65Dn/J
001833   B6 x B6EiC3Sn a/A-T(1C2;16C3)45Dn/J
001903   B6 x B6EiC3Sn a/A-T(6F;18C)57Dn/J
001535   B6 x B6EiC3Sn a/A-T(8A4;12D1)69Dn/J
001831   B6 x B6EiC3Sn a/A-T(8C3;16B5)164Dn/J
000618   B6 x FSB/GnEi a/a Ctslfs/J
000577   B6 x STOCK a Oca2p Hps5ru2 Ednrbs/J
000601   B6 x STOCK a/a T(7;18)50H/J
000592   B6 x STOCK T(2;4)13H a/J
000769   B6.C/(HZ18)By-at-44J/J
000203   B6.C3-Aiy/a/J
000017   B6.C3-Avy/J
001572   B6.C3-am-J/J
000628   B6.CE-A Amy1b Amy2a5b/J
000021   B6.Cg-Ay/J
014608   B6;129S1-a Kitlsl-24J/GrsrJ
000231   B6;C3Fe a/a-Csf1op/J
004200   B6;CBACa Aw-J/A-Npr2cn-2J/GrsrJ
000785   B6;D2-a Ces1ce/EiJ
000604   B6C3 a/A-T(10;13)199H +/+ Lystbg-J/J or Lystbg-2J/J
001750   B6C3Fe a/a-Eif3cXs-J/J
002807   B6C3Fe a/a-Meox2fla/J
000506   B6C3Fe a/a-Qkqk-v/J
000224   B6C3Fe a/a-Scyl1mdf/J
003020   B6C3Fe a/a-Zdhhc21dep/J
001037   B6C3Fe a/a-Agtpbp1pcd/J
000221   B6C3Fe a/a-Alx4lst-J/J
002062   B6C3Fe a/a-Atp7aMo-8J/J
001756   B6C3Fe a/a-Cacng2stg/J
001815   B6C3Fe a/a-Col1a2oim/J
000209   B6C3Fe a/a-Dh/J
000211   B6C3Fe a/a-Dstdt-J/J
000210   B6C3Fe a/a-Edardl-J/J
000207   B6C3Fe a/a-Edaraddcr/J
000182   B6C3Fe a/a-Eef1a2wst/J
001278   B6C3Fe a/a-Glra1spd/J
000241   B6C3Fe a/a-Glrbspa/J
002875   B6C3Fe a/a-Hoxd13spdh/J
000304   B6C3Fe a/a-Krt71Ca Scn8amed-J/J
000226   B6C3Fe a/a-Largemyd/J
000636   B6C3Fe a/a-Lmx1adr-J/J
001280   B6C3Fe a/a-Lse/J
001573   B6C3Fe a/a-MitfMi/J
001035   B6C3Fe a/a-Napahyh/J
000181   B6C3Fe a/a-Otogtwt/J
000278   B6C3Fe a/a-Papss2bm Hps1ep Hps6ru/J
000205   B6C3Fe a/a-Papss2bm/J
002078   B6C3Fe a/a-Pcdh15av-2J/J
000246   B6C3Fe a/a-Pitpnavb/J
001430   B6C3Fe a/a-Ptch1mes/J
000235   B6C3Fe a/a-Relnrl/J
000237   B6C3Fe a/a-Rorasg/J
000290   B6C3Fe a/a-Sox10Dom/J
000230   B6C3Fe a/a-Tcirg1oc/J
003612   B6C3Fe a/a-Trak1hyrt/J
001512   B6C3Fe a/a-Ttnmdm/J
001607   B6C3Fe a/a-Unc5crcm/J
000005   B6C3Fe a/a-Wc/J
000243   B6C3Fe a/a-Wnt1sw/J
000248   B6C3Fe a/a-Xpl/J
000624   B6C3Fe a/a-anx/J
008044   B6C3Fe a/a-bpck/J
002018   B6C3Fe a/a-din/J
002339   B6C3Fe a/a-nma/J
000240   B6C3Fe a/a-soc/J
000063   B6C3Fe a/a-sy/J
001055   B6C3Fe a/a-tip/J
000245   B6C3Fe a/a-tn/J
000065   B6C3Fe a/a-we Pax1un at/J
000296   B6C3Fe-a/a Hoxa13Hd Mcoln3Va-J/J
000019   B6C3Fe-a/a-Itpr1opt/J
003301   B6C3FeF1 a/A-Eya1bor/J
001022   B6C3FeF1/J a/a
000314   B6CBACa Aw-J/A-EdaTa/J-XO
006450   B6EiC3 a/A-Vss/GrsrJ
000971   B6EiC3 a/A-Och/J
000551   B6EiC3 a/A-Tbx15de-H/J
000557   B6EiC3-+ a/LnpUl A/J
000504   B6EiC3Sn a/A-Cacnb4lh/J
000553   B6EiC3Sn a/A-Egfrwa2 Wnt3avt/J
000503   B6EiC3Sn a/A-Gy/J
001811   B6EiC3Sn a/A-Otcspf-ash/J
002343   B6EiC3Sn a/A-Otcspf/J
000391   B6EiC3Sn a/A-Pax6Sey-Dey/J
001923   B6EiC3Sn a/A-Ts(417)2Lws TimT(4;17)3Lws/J
001875   B6EiC3SnF1/J
000638   C3FeB6 A/Aw-J-Sptbn4qv-J/J
000200   C3FeB6 A/Aw-J-Ankank/J
000225   C3FeLe.B6 a/a-Ptpn6me/J
000198   C3FeLe.B6-a/J
000291   C3FeLe.Cg-a/a Hm KitlSl Krt71Ca-J/J
001272   C3H/HeSnJ-Ahvy/J
000099   C3HeB/FeJ-Avy/J
001886   C3HeB/FeJLe a/a-gnd/J
000584   C57BL/6J-+ T(1;2)5Ca/a +/J
000258   C57BL/6J-Ai/a/J
000774   C57BL/6J-Asy/a/J
000055   C57BL/6J-at-33J/J
000070   C57BL/6J-atd/J
000284   CWD/LeJ
000670   DBA/1J
000671   DBA/2J
001057   HPT/LeJ
000260   JGBF/LeJ
002468   KK.Cg-Ay/J
000262   LS/LeJ
000283   LT.CAST-A/J
000265   MY/HuLeJ
000308   SSL/LeJ
001759   STOCK A Tyrc Sha/J
001427   STOCK Aw us/J
000994   STOCK a Myo5ad Mregdsu/J
000064   STOCK a Tyrp1b Pmelsi/J
002238   STOCK a Tyrp1b shmy/J
001433   STOCK a skt/J
000579   STOCK a tp/J
000319   STOCK a us/J
002648   STOCK a/a Cln6nclf/J
000317   STOCK a/a Egfrwa2/J
000302   STOCK a/a MitfMi-wh +/+ Itpr1opt/J
000286   STOCK a/a Myo5ad fd/+ +/J
000281   STOCK a/a Tmem79ma Flgft/J
000206   STOCK a/a Tyrc-h/J
001432   STOCK a/a Tyrp1b Ndc1sks/Tyrp1b +/J
000312   STOCK stb + a/+ Fignfi a/J
000596   STOCK T(2;11)30H/+ x AEJ-a Gdf5bp-H/J or A/J-a Gdf5bp-J/J
000970   STOCK T(2;16)28H A/T(2;16)28H a/J
000590   STOCK T(2;4)1Sn a/J
000594   STOCK T(2;8)26H a/T(2;8)26H a Tyrp1+/Tyrp1b/J
000623   TR/DiEiJ
001145   WSB/EiJ
View Strains carrying other alleles of a     (154 strains)

Additional Web Information

JAX® NOTES, January 1990, 440. Tabby Stocks Available from The Jackson Laboratory.

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested.
Ectodermal Dysplasia 1, Hypohidrotic, X-Linked; XHED   (EDA)
Pelizaeus-Merzbacher Disease; PMD   (PLP1)
Spastic Paraplegia 2, X-Linked; SPG2   (PLP1)
Tooth Agenesis, Selective, X-Linked, 1; STHAGX1   (EDA)
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

Plp1jp/Y

        B6CB-Aw-J/A EdaTa Plp1jp
  • behavior/neurological phenotype
  • abnormal startle reflex
    • onset is developmentally delayed   (MGI Ref ID J:18363)
  • abnormal vocalization
    • up to P8, mice exhibit less ultrasonic vocalizations compared with wild-type mice   (MGI Ref ID J:18363)
  • hypoactivity
  • nervous system phenotype
  • abnormal astrocyte physiology
    • cell cycle length of astrocytes is increased by 5 to 6 hours compared with wild-type cells   (MGI Ref ID J:116364)
  • abnormal myelination   (MGI Ref ID J:5611)
    • microsomes prepared from brains of 18 day old homozygotes show a reduction in fatty acid chain elongation activity with arachidoyl CoA, behenoyl CoA, and palmitoyl CoA substrates   (MGI Ref ID J:160743)
  • abnormal oligodendrocyte morphology
    • as myelination advances oligodendrocytes become abnormal with lipid inclusions and multimembrane tubes unlike in wild-type mice   (MGI Ref ID J:5611)
    • decreased oligodendrocyte number
      • during the early period of myelination (1 to 6 days of age)   (MGI Ref ID J:5611)
  • growth/size/body phenotype
  • decreased body weight   (MGI Ref ID J:18363)
  • vision/eye phenotype
  • delayed eyelid opening   (MGI Ref ID J:18363)

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

Plp1jp/Plp1+

        B6CB-Aw-J/A EdaTa Plp1jp
  • nervous system phenotype
  • astrocytosis   (MGI Ref ID J:6895)

Plp1jp/Y

        Background Not Specified
  • mortality/aging
  • premature death
    • death usually occurs by 30 days commonly after a seizure   (MGI Ref ID J:13141)
    • mice die at around 28 days with some living as long as 40 days   (MGI Ref ID J:288)
  • nervous system phenotype
  • abnormal astrocyte morphology
    • freeze-etching of optic nerves shows that plasmalemma of astrocytes have twice normal numbers of assemblies of 7nm particles, which are similar to type III gap junctions, and these appear to unite abnormally with type I junctions   (MGI Ref ID J:159601)
  • abnormal brain morphology
    • brain contains traces of cholesterol ester   (MGI Ref ID J:13141)
    • abnormal brain white matter morphology
      • cytoplasmic nonpolar lipids are observed in the basis pedunculi, optic tract and white matter of the cerebellum and spinal cord; these cells appear to be fatty macrophages and are first observed in the 12 day old brain   (MGI Ref ID J:13141)
  • abnormal myelin sheath morphology
    • freeze-etching of optic nerves shows abnormally smooth protoplasmic fracture faces and exoplasmic fracture faces and there are fewer than normal intramyelinic tight junctions   (MGI Ref ID J:159601)
  • abnormal myelination
    • little myelin is found in any region of the central nervous system   (MGI Ref ID J:13141)
    • myelination is observed in the peripheral nervous system   (MGI Ref ID J:13141)
    • general architecture of gray and white matter is normal   (MGI Ref ID J:13141)
  • abnormal oligodendrocyte morphology
    • freeze-etching of optic nerves shows that the oligodendroglia plasma membrane is highly convoluted with numerous irregular invaginations and elevations   (MGI Ref ID J:159601)
  • environmentally induced seizures
    • when disturbed or handled mice exhibit convulsions characterized by body tension with head thrown back, fore limbs scrabbling and hind limbs stretched sideways for about 5 seconds sometimes followed by rigid extensor tetanus lasting 20 seconds unlike wild-type mice   (MGI Ref ID J:288)
  • tonic-clonic seizures
    • generalized seizures without focal onset occur by 4 weeks of age   (MGI Ref ID J:13141)
  • behavior/neurological phenotype
  • environmentally induced seizures
    • when disturbed or handled mice exhibit convulsions characterized by body tension with head thrown back, fore limbs scrabbling and hind limbs stretched sideways for about 5 seconds sometimes followed by rigid extensor tetanus lasting 20 seconds unlike wild-type mice   (MGI Ref ID J:288)
  • hindlimb paralysis
    • observed in some mice   (MGI Ref ID J:13141)
  • paraparesis
    • some animals exhibit hindlimb weakness by weaning age   (MGI Ref ID J:13141)
  • tonic-clonic seizures
    • generalized seizures without focal onset occur by 4 weeks of age   (MGI Ref ID J:13141)
  • tremors
    • tremors are first observed at about10-12 days of age   (MGI Ref ID J:13141)
    • mice exhibit intention tremors   (MGI Ref ID J:288)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

EdaTa related

Dermatology Research
Color and White Spotting Defects
Skin and Hair Texture Defects

Developmental Biology Research
Eye Defects

Sensorineural Research
Eye Defects

Plp1jp related

Neurobiology Research
Myelination Defects
Tremor Defects

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Aw-J
Allele Name white bellied agouti Jackson
Allele Type Spontaneous
Common Name(s) AWJ;
Strain of OriginC57BL/6J
Gene Symbol and Name a, nonagouti
Chromosome 2
Gene Common Name(s) AGSW; AGTI; AGTIL; ASP; As; SHEP9; agouti; agouti signal protein; agouti suppressor;
 
Allele Symbol EdaTa
Allele Name tabby
Allele Type Spontaneous
Common Name(s) Ta; Ta3; TaFa; Taf;
Strain of Originstock including A, C57BL, CBA, and RIII
Gene Symbol and Name Eda, ectodysplasin-A
Chromosome X
Gene Common Name(s) EDA1; Ed1; Eda-A1; Eda-A2; RGD1563178; Ta; tabby;
General Note This mutation arose in a strain selected for large size. Hemizygous mutant males breed satisfactorily, but homozygous mutant females are often sterile. Hemizygous mutant females are fully fertile (J:249).Hemizygous males and homozygous females are identical in phenotype with homozygous crinkled (Edaraddcr) and downless (Edardl) mice and with homozygous or heterozygous sleek (Dlslk) mice. They are characterized by absence of guard hairs and zigzags in the coat, a bald patch behind the ear, bald tail with a few kinks near the tip, reduced aperture of the eyelids, a respiratory disorder, and a modified agouti pattern (J:249). The number of vibrissae is reduced (J:14912). The incisors may be reduced or absent, and the molars are usually smaller than normal with the third molar often absent (J:5018, J:5138). There are defects of many endocrine glands. The structures affected by the mutation all arise embryologically as downgrowths of solid epithelial cords, not by invagination with a lumen or by outgrowths from deep grooves (J:5246).Hemizygous mutant females are most easily recognized if they are agouti, in which case they show transverse stripes of light-colored normal and dark tabby hair. They have normal incisors but may have mutant or intermediate-type molars (J:5138). A small proportion of heterozygous females may show some slight defects of some of the exocrine glands (J:5193).In the development of the coat of homozygous and hemizygous mutant mice, hair follicle initiation begins at 17 days of gestation, 3 days later than normal, and ends 1 or 2 days after birth, several days earlier than normal. The hairs are of only one type and resemble abnormal awls (J:12100, J:5137). By use of dermal--epidermal recombination grafts of embryonic flank skin, it was shown that EdaTa acts in the epidermis in its effects on structure of the hairs (J:6041). The effect of the mutation in preventing growth of hair on the tail may be either dermal or epidermal. The mutation may act directly on hair cells or via a diffusible product (J:7450). The phenotype of EdaTa/+ females has been extensively studied because of its relevance to the X-inactivation theory of dosage compensation (J:5018, J:5238).EdaTa and the related mutations Edaraddcr and Edardl disrupt normal development of certain epidermal derivatives, including sweat glands. Although the sensory innervation of footpad skin and the sympathetic innervation of blood vessels in the foot pad is normal in these mutants, the sympathetic fibers that normally innervate the sweat glands fail to develop (J:19910).A candidate gene for the human familial X-linked disorder hypohidrotic ectodermal dysplasia (EDA)(OMIM 305100) has been partially cloned. Eda, a candidate for which has also been cloned, is the homologous gene in the mouse, on the basis of phenotype - hypoplasia of sweat glands, teeth, and hair - and of homologous mapping. There is high sequence identity between the cloned portions of the two genes. Known Eda mutations have been identified in the candidate mouse gene. An extracellular collagenous domain of the mouse gene, not yet identified in the EDA gene, may represent the location of mutations in 85-90% of human families (J:42614). A mouse gene Eda (ectodysplasin-A) has been proposed as the site of the tabby mutations (J:44605).Exogenous epidermal growth factor can reverse phenotypic features of EdaTa mice, advancing the delayed opening of eyelids and eruption of incisors (J:42661) and inducing development of dermal ridges and functional sweat glands (J:42660). Expression of epidermal growth factor receptor is reduced in EDA and in EdaTa mice (J:33361).
Molecular Note This allele is characterized by an ~ 2 kb deletion: Genomic DNA was hybridized with an exon 1 probe showing a deletion including the coding region and primers for DNA flanking exon 1 failed to amplify in a PCR assay. [MGI Ref ID J:42614] [MGI Ref ID J:44605]
 
Allele Symbol Plp1jp
Allele Name jimpy
Allele Type Spontaneous
Common Name(s) jp;
Strain of Origin(KLM STOCK x XY STOCK)F1
Gene Symbol and Name Plp1, proteolipid protein (myelin) 1
Chromosome X
Gene Common Name(s) DM20; GPM6C; HLD1; MMPL; PLP; PLP/DM20; PMD; Plp; SPG2; jimpy; jp; msd; myelin synthesis deficiency; proteolipid protein (myelin); rsh; rump shaker;
Molecular Note Sequence analysis showed that this allele carries an A to G base change at the 3'splice acceptor site of intron 4. [MGI Ref ID J:20245] [MGI Ref ID J:42978] [MGI Ref ID J:42979] [MGI Ref ID J:8332] [MGI Ref ID J:8514]

Genotyping

Genotyping Information

Genotyping Protocols

Plp1jp, Pyrosequencing
Aw-J, Separated PCR


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Additional References

Dautigny A; Mattei MG; Morello D; Alliel PM; Pham-Dinh D; Amar L; Arnaud D; Simon D; Mattei JF; Guenet JL; Avner P. 1986. The structural gene coding for myelin-associated proteolipid protein is mutated in jimpy mice. Nature 321(6073):867-9. [PubMed: 2425262]  [MGI Ref ID J:8332]

Ferguson BM; Brockdorff N; Formstone E; Ngyuen T; Kronmiller JE; Zonana J. 1997. Cloning of Tabby, the murine homolog of the human EDA gene: evidence for a membrane-associated protein with a short collagenous domain. Hum Mol Genet 6(9):1589-94. [PubMed: 9285798]  [MGI Ref ID J:42614]

Nave KA; Lai C; Bloom FE; Milner RJ. 1986. Jimpy mutant mouse: a 74-base deletion in the mRNA for myelin proteolipid protein and evidence for a primary defect in RNA splicing. Proc Natl Acad Sci U S A 83(23):9264-8. [PubMed: 3466187]  [MGI Ref ID J:8514]

Srivastava AK; Pispa J; Hartung AJ; Du Y; Ezer S; Jenks T; Shimada T; Pekkanen M; Mikkola ML; Ko MS; Thesleff I; Kere J; Schlessinger D. 1997. The Tabby phenotype is caused by mutation in a mouse homologue of the EDA gene that reveals novel mouse and human exons and encodes a protein (ectodysplasin-A) with collagenous domains. Proc Natl Acad Sci U S A 94(24):13069-74. [PubMed: 9371801]  [MGI Ref ID J:44605]

Tvrdik P; Westerberg R; Silve S; Asadi A; Jakobsson A; Cannon B; Loison G; Jacobsson A. 2000. Role of a new mammalian gene family in the biosynthesis of very long chain fatty acids and sphingolipids. J Cell Biol 149(3):707-18. [PubMed: 10791983]  [MGI Ref ID J:61900]

Aw-J related

Aberg T; Wang XP; Kim JH; Yamashiro T; Bei M; Rice R; Ryoo HM; Thesleff I. 2004. Runx2 mediates FGF signaling from epithelium to mesenchyme during tooth morphogenesis. Dev Biol 270(1):76-93. [PubMed: 15136142]  [MGI Ref ID J:92174]

Banerjee H; Das A; Srivastava S; Mattoo HR; Thyagarajan K; Khalsa JK; Tanwar S; Das DS; Majumdar SS; George A; Bal V; Durdik JM; Rath S. 2012. A role for apoptosis-inducing factor in T cell development. J Exp Med 209(9):1641-53. [PubMed: 22869892]  [MGI Ref ID J:191446]

Barsh GS; Epstein CJ. 1989. Physical and genetic characterization of a 75-kilobase deletion associated with al, a recessive lethal allele at the mouse agouti locus. Genetics 121(4):811-8. [PubMed: 2566558]  [MGI Ref ID J:9799]

Baurle J; Vogten H; Grusser-Cornehls U. 1998. Course and targets of the calbindin D-28k subpopulation of primary vestibular afferents. J Comp Neurol 402(1):111-28. [PubMed: 9831049]  [MGI Ref ID J:118430]

Boran T; Lesot H; Peterka M; Peterkova R. 2005. Increased apoptosis during morphogenesis of the lower cheek teeth in tabby/EDA mice. J Dent Res 84(3):228-33. [PubMed: 15723861]  [MGI Ref ID J:112546]

Chinta SJ; Rane A; Yadava N; Andersen JK; Nicholls DG; Polster BM. 2009. Reactive oxygen species regulation by AIF- and complex I-depleted brain mitochondria. Free Radic Biol Med 46(7):939-47. [PubMed: 19280713]  [MGI Ref ID J:145908]

Cui CY; Hashimoto T; Grivennikov SI; Piao Y; Nedospasov SA; Schlessinger D. 2006. Ectodysplasin regulates the lymphotoxin-beta pathway for hair differentiation. Proc Natl Acad Sci U S A 103(24):9142-7. [PubMed: 16738056]  [MGI Ref ID J:111051]

Cui CY; Kunisada M; Esibizione D; Grivennikov SI; Piao Y; Nedospasov SA; Schlessinger D. 2007. Lymphotoxin-beta regulates periderm differentiation during embryonic skin development. Hum Mol Genet 16(21):2583-90. [PubMed: 17673451]  [MGI Ref ID J:129949]

Cunningham D; Spychala K; McLarren KW; Garza LA; Boerkoel CF; Herman GE. 2009. Developmental expression pattern of the cholesterogenic enzyme NSDHL and negative selection of NSDHL-deficient cells in the heterozygous Bpa(1H)/+ mouse. Mol Genet Metab 98(4):356-66. [PubMed: 19631568]  [MGI Ref ID J:155028]

Dickie MM. 1969. Mutations at the agouti locus in the mouse. J Hered 60(1):20-5. [PubMed: 5798139]  [MGI Ref ID J:30922]

Esibizione D; Cui CY; Schlessinger D. 2008. Candidate EDA targets revealed by expression profiling of primary keratinocytes from Tabby mutant mice. Gene 427(1-2):42-6. [PubMed: 18848976]  [MGI Ref ID J:143603]

Granholm DE; Reese RN; Granholm NH. 1996. Agouti alleles alter cysteine and glutathione concentrations in hair follicles and serum of mice (A y/a, A wJ/A wJ, and a/a). J Invest Dermatol 106(3):559-63. [PubMed: 8648194]  [MGI Ref ID J:32132]

Granholm DE; Reese RN; Granholm NH. 1995. Agouti alleles influence thiol concentrations in hair follicles and extrafollicular tissues of mice (Ay/a, AwJ/AwJ, a/a). Pigment Cell Res 8(6):302-6. [PubMed: 8789738]  [MGI Ref ID J:31403]

Hisatomi T; Nakao S; Murakami Y; Noda K; Nakazawa T; Notomi S; Connolly E; She H; Almulki L; Ito Y; Vavvas DG; Ishibashi T; Miller JW. 2012. The regulatory roles of apoptosis-inducing factor in the formation and regression processes of ocular neovascularization. Am J Pathol 181(1):53-61. [PubMed: 22613025]  [MGI Ref ID J:185543]

Jones JM; Huang JD; Mermall V; Hamilton BA; Mooseker MS; Escayg A; Copeland NG; Jenkins NA; Meisler MH. 2000. The mouse neurological mutant flailer expresses a novel hybrid gene derived by exon shuffling between Gnb5 and Myo5a. Hum Mol Genet 9(5):821-8. [PubMed: 10749990]  [MGI Ref ID J:61324]

Kappenman KE; Dvoracek MA; Harvison GA; Fuller BB; Granholm NH. 1992. Tyrosinase abundance and activity in murine hairbulb melanocytes of agouti mutants (C57BL/6J-a/a, Ay/a, and AwJ/AwJ). Pigment Cell Res Suppl 2:79-83. [PubMed: 1409442]  [MGI Ref ID J:1295]

Katoh A; Yoshida T; Himeshima Y; Mishina M; Hirano T. 2005. Defective control and adaptation of reflex eye movements in mutant mice deficient in either the glutamate receptor delta2 subunit or Purkinje cells. Eur J Neurosci 21(5):1315-26. [PubMed: 15813941]  [MGI Ref ID J:101081]

Knapp PE; Adjan VV; Hauser KF. 2009. Cell-specific loss of kappa-opioid receptors in oligodendrocytes of the dysmyelinating jimpy mouse. Neurosci Lett 451(2):114-8. [PubMed: 19110031]  [MGI Ref ID J:146365]

Lee M; Kim A; Chua SC Jr; Obici S; Wardlaw SL. 2007. Transgenic MSH overexpression attenuates the metabolic effects of a high-fat diet. Am J Physiol Endocrinol Metab 293(1):E121-31. [PubMed: 17374695]  [MGI Ref ID J:126508]

Lu W; Tsirka SE. 2002. Partial rescue of neural apoptosis in the Lurcher mutant mouse through elimination of tissue plasminogen activator. Development 129(8):2043-50. [PubMed: 11934869]  [MGI Ref ID J:111363]

Martin LA; Goldowitz D; Mittleman G. 2010. Repetitive behavior and increased activity in mice with Purkinje cell loss: a model for understanding the role of cerebellar pathology in autism. Eur J Neurosci 31(3):544-55. [PubMed: 20105240]  [MGI Ref ID J:159466]

Mayer TC; Fishbane JL. 1972. Mesoderm-ectoderm interaction in the production of the agouti pigmentation pattern in mice. Genetics 71(2):297-303. [PubMed: 4558326]  [MGI Ref ID J:5288]

Mitsumori K; Yasuhara K; Mori I; Hayashi S; Shimo T; Onodera H; Nomura T; Hayashi Y. 1998. Pulmonary fibrosis caused by N-methyl-N-nitrosourethane inhibits lung tumorigenesis by urethane in transgenic mice carrying the human prototype c-Ha-ras gene. Cancer Lett 129(2):181-90. [PubMed: 9719460]  [MGI Ref ID J:52138]

Monroe DG; Wipf LP; Diggins MR; Matthees DP; Granholm NH. 1998. Agouti-related maturation and tissue distribution of alpha-Melanocyte Stimulating Hormone in wild-type (AwJ/AwJ) and mutant (Ay/a,a/a) mice. Pigment Cell Res 11(5):310-3. [PubMed: 9877102]  [MGI Ref ID J:52183]

Mullen RJ. 1974. A<w-J> - white-bellied agouti-J Mouse News Lett 50:38.  [MGI Ref ID J:64104]

Mustonen T; Ilmonen M; Pummila M; Kangas AT; Laurikkala J; Jaatinen R; Pispa J; Gaide O; Schneider P; Thesleff I; Mikkola ML. 2004. Ectodysplasin A1 promotes placodal cell fate during early morphogenesis of ectodermal appendages. Development 131(20):4907-19. [PubMed: 15371307]  [MGI Ref ID J:128256]

O'donnell SM; Hansberger MW; Connolly JL; Chappell JD; Watson MJ; Pierce JM; Wetzel JD; Han W; Barton ES; Forrest JC; Valyi-Nagy T; Yull FE; Blackwell TS; Rottman JN; Sherry B; Dermody TS. 2005. Organ-specific roles for transcription factor NF-kappaB in reovirus-induced apoptosis and disease. J Clin Invest 115(9):2341-2350. [PubMed: 16100570]  [MGI Ref ID J:100906]

Peng J; Wu Z; Wu Y; Hsu M; Stevenson FF; Boonplueang R; Roffler-Tarlov SK; Andersen JK. 2002. Inhibition of caspases protects cerebellar granule cells of the weaver mouse from apoptosis and improves behavioral phenotype. J Biol Chem 277(46):44285-91. [PubMed: 12221097]  [MGI Ref ID J:119427]

Peng J; Xie L; Stevenson FF; Melov S; Di Monte DA; Andersen JK. 2006. Nigrostriatal dopaminergic neurodegeneration in the weaver mouse is mediated via neuroinflammation and alleviated by minocycline administration. J Neurosci 26(45):11644-51. [PubMed: 17093086]  [MGI Ref ID J:114943]

Poole TW. 1975. Dermal-epidermal interactions and the action of alleles at the agouti locus in the mouse. Dev Biol 42(2):203-10. [PubMed: 1090472]  [MGI Ref ID J:5519]

Probst FJ; Cooper ML; Cheung SW; Justice MJ. 2008. Genotype, phenotype, and karyotype correlation in the XO mouse model of Turner Syndrome. J Hered 99(5):512-7. [PubMed: 18499648]  [MGI Ref ID J:138994]

Prtenjaca A; Hill KA. 2011. Mutation frequency is not elevated in the cerebellum of harlequin/Big Blue((R)) mice but Class II deletions occur preferentially in young harlequin cerebellum. Mutat Res 707(1-2):53-60. [PubMed: 21195094]  [MGI Ref ID J:168461]

Smith DE; Xu SG. 2003. Ultrastructural organization of GABA-like immunoreactive profiles in the weaver substantia nigra. J Neurocytol 32(3):293-303. [PubMed: 14724391]  [MGI Ref ID J:121345]

Vandenput L; Swinnen JV; Boonen S; Van Herck E; Erben RG; Bouillon R; Vanderschueren D. 2004. Role of the androgen receptor in skeletal homeostasis: the androgen-resistant testicular feminized male mouse model. J Bone Miner Res 19(9):1462-70. [PubMed: 15312246]  [MGI Ref ID J:111491]

Wu Q; Miller RH; Ransohoff RM; Robinson S; Bu J; Nishiyama A. 2000. Elevated levels of the chemokine GRO-1 correlate with elevated oligodendrocyte progenitor proliferation in the jimpy mutant. J Neurosci 20(7):2609-17. [PubMed: 10729341]  [MGI Ref ID J:109469]

Yamago G; Takata Y; Furuta I; Urase K; Momoi T; Huh N. 2001. Suppression of hair follicle development inhibits induction of sonic hedgehog, patched, and patched-2 in hair germs in mice. Arch Dermatol Res 293(9):435-41. [PubMed: 11758785]  [MGI Ref ID J:116953]

Yoshida T; Katoh A; Ohtsuki G; Mishina M; Hirano T. 2004. Oscillating Purkinje neuron activity causing involuntary eye movement in a mutant mouse deficient in the glutamate receptor delta2 subunit. J Neurosci 24(10):2440-8. [PubMed: 15014119]  [MGI Ref ID J:97010]

Zhang M; Su YQ; Sugiura K; Xia G; Eppig JJ. 2010. Granulosa cell ligand NPPC and its receptor NPR2 maintain meiotic arrest in mouse oocytes. Science 330(6002):366-9. [PubMed: 20947764]  [MGI Ref ID J:164870]

van Empel VP; Bertrand AT; van der Nagel R; Kostin S; Doevendans PA; Crijns HJ; de Wit E; Sluiter W; Ackerman SL; De Windt LJ. 2005. Downregulation of apoptosis-inducing factor in harlequin mutant mice sensitizes the myocardium to oxidative stress-related cell death and pressure overload-induced decompensation. Circ Res 96(12):e92-e101. [PubMed: 15933268]  [MGI Ref ID J:110278]

EdaTa related

Aberg T; Wang XP; Kim JH; Yamashiro T; Bei M; Rice R; Ryoo HM; Thesleff I. 2004. Runx2 mediates FGF signaling from epithelium to mesenchyme during tooth morphogenesis. Dev Biol 270(1):76-93. [PubMed: 15136142]  [MGI Ref ID J:92174]

Blecher SR; Kapalanga J; Lalonde D. 1990. Induction of sweat glands by epidermal growth factor in murine X-linked anhidrotic ectodermal dysplasia. Nature 345(6275):542-4. [PubMed: 2348861]  [MGI Ref ID J:42660]

Boran T; Lesot H; Peterka M; Peterkova R. 2005. Increased apoptosis during morphogenesis of the lower cheek teeth in tabby/EDA mice. J Dent Res 84(3):228-33. [PubMed: 15723861]  [MGI Ref ID J:112546]

Cerghet M; Bessert DA; Nave KA; Skoff RP. 2001. Differential expression of apoptotic markers in jimpy and in Plp overexpressors: evidence for different apoptotic pathways. J Neurocytol 30(9-10):841-55. [PubMed: 12165674]  [MGI Ref ID J:121313]

Charles C; Pantalacci S; Peterkova R; Peterka M; Laudet V; Viriot L. 2007. Disruption of the palatal rugae pattern in Tabby (eda) mutant mice. Eur J Oral Sci 115(6):441-8. [PubMed: 18028050]  [MGI Ref ID J:147677]

Charles C; Pantalacci S; Tafforeau P; Headon D; Laudet V; Viriot L. 2009. Distinct impacts of Eda and Edar loss of function on the mouse dentition. PLoS ONE 4(4):e4985. [PubMed: 19340299]  [MGI Ref ID J:148176]

Claxton JH. 1967. The initiation and development of the hair follicle population in tabby mice. Genet Res 10:161-171.  [MGI Ref ID J:12100]

Dulos GJ; Bagchus WM. 2001. Androgens indirectly accelerate thymocyte apoptosis. Int Immunopharmacol 1(2):321-8. [PubMed: 11360932]  [MGI Ref ID J:109877]

FALCONER DS. 1953. [Total sex-linkage in the house mouse.] Z Indukt Abstamm Vererbungsl 85(2):210-9. [PubMed: 13103353]  [MGI Ref ID J:249]

Falconer DS; Latyszewski M. 1952. The environment in relation to selection for size in mice J Genet 51:67-80.  [MGI Ref ID J:78116]

Ferguson BM; Brockdorff N; Formstone E; Ngyuen T; Kronmiller JE; Zonana J. 1997. Cloning of Tabby, the murine homolog of the human EDA gene: evidence for a membrane-associated protein with a short collagenous domain. Hum Mol Genet 6(9):1589-94. [PubMed: 9285798]  [MGI Ref ID J:42614]

Fliniaux I; Mikkola ML; Lefebvre S; Thesleff I. 2008. Identification of dkk4 as a target of Eda-A1/Edar pathway reveals an unexpected role of ectodysplasin as inhibitor of Wnt signalling in ectodermal placodes. Dev Biol 320(1):60-71. [PubMed: 18508042]  [MGI Ref ID J:138365]

Fraser AS; Kindred BM. 1960. Selection for an invariant character, vibrissa number, in the house mouse. II. Limits to variability Aust J Biol Sci 13:48-58.  [MGI Ref ID J:14912]

Gruneberg H. 1965. Genes and genotypes affecting the teeth of the mouse. J Embryol Exp Morphol 14(2):137-59. [PubMed: 5893447]  [MGI Ref ID J:12999]

Gruneberg H. 1971. The glandular aspects of the tabby syndrome in the mouse. J Embryol Exp Morphol 25(1):1-19. [PubMed: 5548211]  [MGI Ref ID J:5193]

Gruneberg H. 1966. The molars of the tabby mouse, and a test of the 'single-active X-chromosome' hypothesis. J Embryol Exp Morphol 15(2):223-44. [PubMed: 5959976]  [MGI Ref ID J:5018]

Gruneberg H. 1971. The tabby syndrome in the mouse. Proc R Soc Lond B Biol Sci 179(55):139-56. [PubMed: 4399988]  [MGI Ref ID J:5246]

Gruneberg H. 1969. Threshold phenomena versus cell heredity in the manifestation of sex-linked genes in mammals. J Embryol Exp Morphol 22(2):145-79. [PubMed: 5361553]  [MGI Ref ID J:5137]

Guidry G; Landis SC. 1998. Target-dependent development of the vesicular acetylcholine transporter in rodent sweat gland innervation. Dev Biol 199(2):175-84. [PubMed: 9698438]  [MGI Ref ID J:107703]

Haara O; Fujimori S; Schmidt-Ullrich R; Hartmann C; Thesleff I; Mikkola ML. 2011. Ectodysplasin and Wnt pathways are required for salivary gland branching morphogenesis. Development 138(13):2681-91. [PubMed: 21652647]  [MGI Ref ID J:173573]

Hammerschmidt B; Schlake T. 2007. Localization of Shh expression by Wnt and Eda affects axial polarity and shape of hairs. Dev Biol 305(1):246-61. [PubMed: 17376426]  [MGI Ref ID J:121316]

Harsan L; Jalabi W; Grucker D; Ghandour MS. 2004. New insights on neuronal alterations in jimpy mutant brain. Neurochem Res 29(5):943-52. [PubMed: 15139292]  [MGI Ref ID J:106214]

Huh SH; Narhi K; Lindfors PH; Haara O; Yang L; Ornitz DM; Mikkola ML. 2013. Fgf20 governs formation of primary and secondary dermal condensations in developing hair follicles. Genes Dev 27(4):450-8. [PubMed: 23431057]  [MGI Ref ID J:193958]

Isaacs K; Brown G; Moore GP. 1998. Interactions between epidermal growth factor and the Tabby mutation in skin. Exp Dermatol 7(5):273-80. [PubMed: 9832315]  [MGI Ref ID J:53635]

Jamieson RV; Zhou SX; Wheatley SC; Koopman P; Tam PP. 1998. Sertoli cell differentiation and Y-chromosome activity: a developmental study of X-linked transgene activity in sex-reversed X/XSxra mouse embryos. Dev Biol 199(2):235-44. [PubMed: 9698443]  [MGI Ref ID J:107693]

Jaskoll T; Zhou YM; Trump G; Melnick M. 2003. Ectodysplasin receptor-mediated signaling is essential for embryonic submandibular salivary gland development. Anat Rec A Discov Mol Cell Evol Biol 271(2):322-31. [PubMed: 12629675]  [MGI Ref ID J:105968]

Johnston DS; Russell LD; Friel PJ; Griswold MD. 2001. Murine germ cells do not require functional androgen receptors to complete spermatogenesis following spermatogonial stem cell transplantation. Endocrinology 142(6):2405-8. [PubMed: 11356688]  [MGI Ref ID J:109878]

Kangas AT; Evans AR; Thesleff I; Jernvall J. 2004. Nonindependence of mammalian dental characters. Nature 432(7014):211-4. [PubMed: 15538367]  [MGI Ref ID J:94561]

Kapalanga J; Blecher SR. 1990. Effect of the X-linked gene Tabby (Ta) on eyelid opening and incisor eruption in neonatal mice is opposite to that of epidermal growth factor. Development 108(2):349-55. [PubMed: 2351074]  [MGI Ref ID J:42661]

Knapp PE; Adjan VV; Hauser KF. 2009. Cell-specific loss of kappa-opioid receptors in oligodendrocytes of the dysmyelinating jimpy mouse. Neurosci Lett 451(2):114-8. [PubMed: 19110031]  [MGI Ref ID J:146365]

Knapp PE; Dutta S; Skoff RP. 1990. Differences in levels of neuroglial cell death in jimpy male mice and carrier females. Dev Neurosci 12(3):145-52. [PubMed: 2364893]  [MGI Ref ID J:116371]

Knapp PE; Skoff RP. 1993. Jimpy mutation affects astrocytes: lengthening of the cell cycle in vitro. Dev Neurosci 15(1):31-6. [PubMed: 8269866]  [MGI Ref ID J:116364]

Koppinen P; Pispa J; Laurikkala J; Thesleff I; Mikkola ML. 2001. Signaling and subcellular localization of the TNF receptor Edar. Exp Cell Res 269(2):180-92. [PubMed: 11570810]  [MGI Ref ID J:71957]

Kosaras B; Kirschner DA. 1990. Radial component of CNS myelin: junctional subunit structure and supramolecular assembly. J Neurocytol 19(2):187-99. [PubMed: 2113569]  [MGI Ref ID J:121320]

Kristenova P; Peterka M; Lisi S; Gendrault JL; Lesot H; Peterkova R. 2002. Different morphotypes of functional dentition in the lower molar region of tabby (EDA) mice. Orthod Craniofac Res 5(4):205-14. [PubMed: 12416535]  [MGI Ref ID J:103894]

LYON MF; SEARLE AG; FORD CE; OHNO S. 1964. A MOUSE TRANSLOCATION SUPPRESSING SEX-LINKED VARIEGATION. Cytogenetics 15:306-23. [PubMed: 14248461]  [MGI Ref ID J:149655]

Langton AK; Herrick SE; Headon DJ. 2008. An extended epidermal response heals cutaneous wounds in the absence of a hair follicle stem cell contribution. J Invest Dermatol 128(5):1311-8. [PubMed: 18037901]  [MGI Ref ID J:135502]

Laurikkala J; Mikkola M; Mustonen T; Aberg T; Koppinen P; Pispa J; Nieminen P; Galceran J; Grosschedl R; Thesleff I. 2001. TNF signaling via the ligand-receptor pair ectodysplasin and edar controls the function of epithelial signaling centers and is regulated by Wnt and activin during tooth organogenesis. Dev Biol 229(2):443-55. [PubMed: 11203701]  [MGI Ref ID J:67054]

Laurikkala J; Pispa J; Jung HS; Nieminen P; Mikkola M; Wang X; Saarialho-Kere U; Galceran J; Grosschedl R; Thesleff I. 2002. Regulation of hair follicle development by the TNF signal ectodysplasin and its receptor Edar. Development 129(10):2541-53. [PubMed: 11973284]  [MGI Ref ID J:75943]

Le Goascogne C; Eychenne B; Tonon MC; Lachapelle F; Baumann N; Robel P. 2000. Neurosteroid progesterone is up-regulated in the brain of jimpy and shiverer mice. Glia 29(1):14-24. [PubMed: 10594919]  [MGI Ref ID J:78788]

Le Goascogne C; Sannanes N; Gouezou M; Baulieu EE; Robel P. 1993. Suppressed expression of the cytochrome P45017 alpha protein in the testicular feminized (Tfm) mouse testes. J Endocrinol 139(1):127-30. [PubMed: 8254285]  [MGI Ref ID J:15718]

Lyon MF. 1963. Attempts to test the inactive-X theory of dosage compensation in mammals Genet Res 4:93-103.  [MGI Ref ID J:272]

Lyon MF. 1970. Genetic activity of sex chromosomes in somatic cells of mammals. Philos Trans R Soc Lond B Biol Sci 259(828):41-52. [PubMed: 4399067]  [MGI Ref ID J:5238]

Mayer TC; Green MC. 1978. Epidermis is the site of action of tabby (Ta) in the mouse. Genetics 90(1):125-31. [PubMed: 359407]  [MGI Ref ID J:6041]

Melnick M; Phair RD; Lapidot SA; Jaskoll T. 2009. Salivary gland branching morphogenesis: a quantitative systems analysis of the Eda/Edar/NFkappaB paradigm. BMC Dev Biol 9:32. [PubMed: 19500387]  [MGI Ref ID J:152818]

Miard S; Peterkova R; Vonesch JL; Peterka M; Ruch JV; Lesot H. 1999. Alterations in the incisor development in the Tabby mouse. Int J Dev Biol 43(6):517-29. [PubMed: 10610025]  [MGI Ref ID J:104871]

Mou C; Jackson B; Schneider P; Overbeek PA; Headon DJ. 2006. Generation of the primary hair follicle pattern. Proc Natl Acad Sci U S A 103(24):9075-80. [PubMed: 16769906]  [MGI Ref ID J:111052]

Mustonen T; Ilmonen M; Pummila M; Kangas AT; Laurikkala J; Jaatinen R; Pispa J; Gaide O; Schneider P; Thesleff I; Mikkola ML. 2004. Ectodysplasin A1 promotes placodal cell fate during early morphogenesis of ectodermal appendages. Development 131(20):4907-19. [PubMed: 15371307]  [MGI Ref ID J:128256]

Narhi K; Jarvinen E; Birchmeier W; Taketo MM; Mikkola ML; Thesleff I. 2008. Sustained epithelial {beta}-catenin activity induces precocious hair development but disrupts hair follicle down-growth and hair shaft formation. Development 135(6):1019-28. [PubMed: 18256193]  [MGI Ref ID J:131961]

Pantalacci S; Prochazka J; Martin A; Rothova M; Lambert A; Bernard L; Charles C; Viriot L; Peterkova R; Laudet V. 2008. Patterning of palatal rugae through sequential addition reveals an anterior/posterior boundary in palatal development. BMC Dev Biol 8:116. [PubMed: 19087265]  [MGI Ref ID J:145173]

Pennycuik PR; Raphael KA. 1984. The tabby locus (Ta) in the mouse: its site of action in tail and body skin. Genet Res 43(1):51-63. [PubMed: 6373499]  [MGI Ref ID J:7450]

Peterkova R; Kristenova P; Lesot H; Lisi S; Vonesch JL; Gendrault JL; Peterka M. 2002. Different morphotypes of the tabby (EDA) dentition in the mouse mandible result from a defect in the mesio-distal segmentation of dental epithelium. Orthod Craniofac Res 5(4):215-26. [PubMed: 12416536]  [MGI Ref ID J:103893]

Peterkova R; Lesot H; Viriot L; Peterka M. 2005. The supernumerary cheek tooth in tabby/EDA mice-a reminiscence of the premolar in mouse ancestors. Arch Oral Biol 50(2):219-25. [PubMed: 15721153]  [MGI Ref ID J:98533]

Pispa J; Jung HS; Jernvall J; Kettunen P; Mustonen T; Tabata MJ; Kere J; Thesleff I. 1999. Cusp patterning defect in Tabby mouse teeth and its partial rescue by FGF. Dev Biol 216(2):521-34. [PubMed: 10642790]  [MGI Ref ID J:59068]

Pispa J; Pummila M; Barker PA; Thesleff I; Mikkola ML. 2008. Edar and Troy signalling pathways act redundantly to regulate initiation of hair follicle development. Hum Mol Genet 17(21):3380-91. [PubMed: 18689798]  [MGI Ref ID J:140329]

Probst FJ; Cooper ML; Cheung SW; Justice MJ. 2008. Genotype, phenotype, and karyotype correlation in the XO mouse model of Turner Syndrome. J Hered 99(5):512-7. [PubMed: 18499648]  [MGI Ref ID J:138994]

Rao MS; Jaszczak E; Landis SC. 1994. Innervation of footpads of normal and mutant mice lacking sweat glands. J Comp Neurol 346(4):613-25. [PubMed: 7983247]  [MGI Ref ID J:19910]

Rawlins EL; Hogan BL. 2005. Intercellular growth factor signaling and the development of mouse tracheal submucosal glands. Dev Dyn 233(4):1378-85. [PubMed: 15973734]  [MGI Ref ID J:119848]

Risnes S; Peterkova R; Lesot H. 2005. Distribution and structure of dental enamel in incisors of Tabby mice. Arch Oral Biol 50(2):181-4. [PubMed: 15721148]  [MGI Ref ID J:100300]

Schmidt-Ullrich R; Tobin DJ; Lenhard D; Schneider P; Paus R; Scheidereit C. 2006. NF-{kappa}B transmits Eda A1/EdaR signalling to activate Shh and cyclin D1 expression, and controls post-initiation hair placode down growth. Development 133(6):1045-57. [PubMed: 16481354]  [MGI Ref ID J:106549]

Silvers WK. 1979. The Coat Colors of Mice; A Model for Mammalian Gene Action and Interaction. In: The Coat Colors of Mice. Springer-Verlag, New York.  [MGI Ref ID J:78801]

Sofaer JA. 1979. Additive effects of the genes tabby and crinkled on tooth size in the mouse. Genet Res 33(2):169-74. [PubMed: 478295]  [MGI Ref ID J:151073]

Sofaer JA. 1969. Aspects of the tabby-crinkled-downless syndrome. I. The development of tabby teeth. J Embryol Exp Morphol 22(2):181-205. [PubMed: 5361554]  [MGI Ref ID J:5138]

Sofaer JA. 1969. Aspects of the tabby-crinkled-downless syndrome. II. Observations on the reaction to changes of genetic background. J Embryol Exp Morphol 22(2):207-27. [PubMed: 5361555]  [MGI Ref ID J:5139]

Sofaer JA. 1974. Differences between tabby and downless mouse epidermis and dermis in culture. Genet Res 23(2):219-25. [PubMed: 4420168]  [MGI Ref ID J:5489]

Sofaer JA; MacLean CJ. 1970. Dominance in threshold characters. A comparison of two tabby alleles in the mouse. Genetics 64(2):273-80. [PubMed: 5470481]  [MGI Ref ID J:5176]

Srivastava AK; Durmowicz MC; Hartung AJ; Hudson J; Ouzts LV; Donovan DM; Cui CY; Schlessinger D. 2001. Ectodysplasin-A1 is sufficient to rescue both hair growth and sweat glands in Tabby mice. Hum Mol Genet 10(26):2973-81. [PubMed: 11751679]  [MGI Ref ID J:73715]

Srivastava AK; Pispa J; Hartung AJ; Du Y; Ezer S; Jenks T; Shimada T; Pekkanen M; Mikkola ML; Ko MS; Thesleff I; Kere J; Schlessinger D. 1997. The Tabby phenotype is caused by mutation in a mouse homologue of the EDA gene that reveals novel mouse and human exons and encodes a protein (ectodysplasin-A) with collagenous domains. Proc Natl Acad Sci U S A 94(24):13069-74. [PubMed: 9371801]  [MGI Ref ID J:44605]

Sundberg JP (ed.). 1994. Handbook of Mouse Mutations with Skin and Hair Abnormalities: Animal Models and Biomedical Tools. In: Handbook of Mouse Mutations with Skin and Hair Abnormalities: Animal Models and Biomedical Tools. CRC Press, Boca Raton.  [MGI Ref ID J:30359]

Toda I; Sullivan BD; Wickham LA; Sullivan DA. 1999. Gender- and androgen-related influence on the expression of proto-oncogene and apoptotic factor mRNAs in lacrimal glands of autoimmune and non-autoimmune mice. J Steroid Biochem Mol Biol 71(1-2):49-61. [PubMed: 10619357]  [MGI Ref ID J:58967]

Tucker AS; Headon DJ; Courtney JM; Overbeek P; Sharpe PT. 2004. The activation level of the TNF family receptor, Edar, determines cusp number and tooth number during tooth development. Dev Biol 268(1):185-94. [PubMed: 15031115]  [MGI Ref ID J:92196]

Turtzo LC; Siegel C; McCullough LD. 2011. X chromosome dosage and the response to cerebral ischemia. J Neurosci 31(37):13255-9. [PubMed: 21917808]  [MGI Ref ID J:191548]

Vargas GA; Fantino E; George-Nascimento C; Gargus JJ; Haigler HT. 1996. Reduced epidermal growth factor receptor expression in hypohidrotic ectodermal dysplasia and Tabby mice. J Clin Invest 97(11):2426-32. [PubMed: 8647934]  [MGI Ref ID J:33361]

Vielkind U; Hardy MH. 1996. Changing patterns of cell adhesion molecules during mouse pelage hair follicle development. 2. Follicle morphogenesis in the hair mutants, Tabby and downy. Acta Anat (Basel) 157(3):183-94. [PubMed: 9226037]  [MGI Ref ID J:41386]

Voutilainen M; Lindfors PH; Lefebvre S; Ahtiainen L; Fliniaux I; Rysti E; Murtoniemi M; Schneider P; Schmidt-Ullrich R; Mikkola ML. 2012. Ectodysplasin regulates hormone-independent mammary ductal morphogenesis via NF-kappaB. Proc Natl Acad Sci U S A 109(15):5744-9. [PubMed: 22451941]  [MGI Ref ID J:183539]

Wells KL; Mou C; Headon DJ; Tucker AS. 2011. Defects and rescue of the minor salivary glands in Eda pathway mutants. Dev Biol 349(2):137-46. [PubMed: 20969842]  [MGI Ref ID J:168036]

Wells KL; Mou C; Headon DJ; Tucker AS. 2010. Recombinant EDA or Sonic Hedgehog rescue the branching defect in Ectodysplasin A pathway mutant salivary glands in vitro. Dev Dyn :. [PubMed: 20803597]  [MGI Ref ID J:164212]

Yamago G; Takata Y; Furuta I; Urase K; Momoi T; Huh N. 2001. Suppression of hair follicle development inhibits induction of sonic hedgehog, patched, and patched-2 in hair germs in mice. Arch Dermatol Res 293(9):435-41. [PubMed: 11758785]  [MGI Ref ID J:116953]

Zhang Y; Tomann P; Andl T; Gallant NM; Huelsken J; Jerchow B; Birchmeier W; Paus R; Piccolo S; Mikkola ML; Morrisey EE; Overbeek PA; Scheidereit C; Millar SE; Schmidt-Ullrich R. 2009. Reciprocal requirements for EDA/EDAR/NF-kappaB and Wnt/beta-catenin signaling pathways in hair follicle induction. Dev Cell 17(1):49-61. [PubMed: 19619491]  [MGI Ref ID J:151982]

Plp1jp related

Bakalian A; Kopmels B; Messer A; Fradelizi D; Delhaye-Bouchaud N; Wollman E; Mariani J. 1992. Peripheral macrophage abnormalities in mutant mice with spinocerebellar degeneration. Res Immunol 143(1):129-39. [PubMed: 1565842]  [MGI Ref ID J:2228]

Baracskay KL; Duchala CS; Miller RH; Macklin WB; Trapp BD. 2002. Oligodendrogenesis is differentially regulated in gray and white matter of jimpy mice. J Neurosci Res 70(5):645-54. [PubMed: 12424732]  [MGI Ref ID J:105526]

Benjamins JA; Studzinski DM; Skoff RP. 1994. Analysis of myelin proteolipid protein and F0 ATPase subunit 9 in normal and jimpy CNS. Neurochem Res 19(8):1013-22. [PubMed: 7528346]  [MGI Ref ID J:19841]

Billings-Gagliardi S; Adcock LH; Lamperti ED; Schwing-Stanhope G; Wolf MK. 1983. Myelination of jp,jpmsd, and qk axons by normal glia in vitro: ultrastructural and autoradiographic evidence. Brain Res 268(2):255-66. [PubMed: 6871684]  [MGI Ref ID J:7126]

Billings-Gagliardi S; Adcock LH; Schwing GB; Wolf MK. 1980. Hypomyelinated mutant mice. II. Myelination in vitro. Brain Res 200(1):135-50. [PubMed: 7417802]  [MGI Ref ID J:160672]

Billings-Gagliardi S; Karthigasan J; Kirschner DA; Wolf MK. 1990. Quaking*jimpy double mutant mice: additional evidence for independence of primary deficits in jimpy. Brain Res Mol Brain Res 7(3):189-98. [PubMed: 1692389]  [MGI Ref ID J:160671]

Boison D; Stoffel W. 1994. Disruption of the compacted myelin sheath of axons of the central nervous system in proteolipid protein-deficient mice. Proc Natl Acad Sci U S A 91(24):11709-13. [PubMed: 7526402]  [MGI Ref ID J:21976]

Bolivar VJ; Brown RE. 1995. Selective retrieval of jimpy mutant pups over normal male littermates by lactating female B6CBACa-Aw-J/A-Ta jp mice. Behav Genet 25(1):75-80. [PubMed: 7755521]  [MGI Ref ID J:23638]

Bolivar VJ; Brown RE. 1994. The ontogeny of ultrasonic vocalizations and other behaviors in male jimpy (jp/Y) mice and their normal male littermates. Dev Psychobiol 27(2):101-10. [PubMed: 8187967]  [MGI Ref ID J:18363]

Cammer W; Zhang H. 1999. Atypical glial cells in demyelinated and hypomyelinated mouse brains. Brain Res 837(1-2):188-92. [PubMed: 10434002]  [MGI Ref ID J:56773]

Campagnoni AT; Campagnoni CW; Bourre JM; Jacque C; Baumann N. 1984. Cell-free synthesis of myelin basic proteins in normal and dysmyelinating mutant mice. J Neurochem 42(3):733-9. [PubMed: 6198470]  [MGI Ref ID J:7310]

Campagnoni CW; Garbay B; Micevych P; Pribyl T; Kampf K; Handley VW; Campagnoni AT. 1992. DM20 mRNA splice product of the myelin proteolipid protein gene is expressed in the murine heart. J Neurosci Res 33(1):148-55. [PubMed: 1280689]  [MGI Ref ID J:3020]

Cattanach BM; Beechey CV. 1991. Evidence of allelism between rumpshaker and jimpy. Mouse Genome 89:271.  [MGI Ref ID J:14304]

Cerghet M; Bessert DA; Nave KA; Skoff RP. 2001. Differential expression of apoptotic markers in jimpy and in Plp overexpressors: evidence for different apoptotic pathways. J Neurocytol 30(9-10):841-55. [PubMed: 12165674]  [MGI Ref ID J:121313]

Chen H; Cabon F; Sun P; Parmantier E; Dupouey P; Jacque C; Zalc B. 1993. Regional and developmental variations of GFAP and actin mRNA levels in the CNS of jimpy and shiverer mutant mice. J Mol Neurosci 4(2):89-96. [PubMed: 8217522]  [MGI Ref ID J:17936]

Dautigny A; Mattei MG; Morello D; Alliel PM; Pham-Dinh D; Amar L; Arnaud D; Simon D; Mattei JF; Guenet JL; Avner P. 1986. The structural gene coding for myelin-associated proteolipid protein is mutated in jimpy mice. Nature 321(6073):867-9. [PubMed: 2425262]  [MGI Ref ID J:8332]

Denisenko-Nehrbass N; Goutebroze L; Galvez T; Bonnon C; Stankoff B; Ezan P; Giovannini M; Faivre-Sarrailh C; Girault JA. 2003. Association of Caspr/paranodin with tumour suppressor schwannomin/merlin and beta1 integrin in the central nervous system. J Neurochem 84(2):209-21. [PubMed: 12558984]  [MGI Ref ID J:126709]

Duncan ID. 1990. Dissection of the phenotype and genotype of the X-linked myelin mutants. Ann N Y Acad Sci 605:110-21. [PubMed: 2268114]  [MGI Ref ID J:160048]

Edelman GM; Chuong CM. 1982. Embryonic to adult conversion of neural cell adhesion molecules in normal and staggerer mice. Proc Natl Acad Sci U S A 79(22):7036-40. [PubMed: 6960362]  [MGI Ref ID J:6930]

Edgar JM; Anderson TJ; Dickinson PJ; Barrie JA; McCulloch MC; Nave KA; Griffiths IR. 2002. Survival of, and competition between, oligodendrocytes expressing different alleles of the Plp gene. J Cell Biol 158(4):719-29. [PubMed: 12177040]  [MGI Ref ID J:78727]

Eicher EM. 1972. msd and jp allelic. Mouse News Lett 46:31.  [MGI Ref ID J:13526]

Eicher EM; Hoppe PC. 1973. Use of chimeras to transmit lethal genes in the mouse and to demonstrate allelism of the two X-linked male lethal genes jp and msd. J Exp Zool 183(2):181-4. [PubMed: 4686192]  [MGI Ref ID J:5322]

Fannon AM; Mastronardi FG; Moscarello MA. 1994. Isolation and identification of proteolipid proteins in jimpy mouse brain. Neurochem Res 19(8):1005-12. [PubMed: 7528345]  [MGI Ref ID J:19840]

Feutz AC; Bellomi I; Allinquant B; Schladenhaufen Y; Ghandour MS. 1995. Isolation and characterization of defective jimpy oligodendrocytes in culture. J Neurocytol 24(11):865-77. [PubMed: 8576715]  [MGI Ref ID J:30514]

Frail DE; Braun PE. 1985. Abnormal expression of the myelin-associated glycoprotein in the central nervous system of dysmyelinating mutant mice. J Neurochem 45(4):1071-5. [PubMed: 2411865]  [MGI Ref ID J:7990]

Gotow T; Leterrier JF; Ohsawa Y; Watanabe T; Isahara K; Shibata R; Ikenaka K; Uchiyama Y. 1999. Abnormal expression of neurofilament proteins in dysmyelinating axons located in the central nervous system of jimpy mutant mice. Eur J Neurosci 11(11):3893-903. [PubMed: 10583478]  [MGI Ref ID J:59860]

Griffiths IR; Schneider A; Anderson J; Nave KA. 1995. Transgenic and natural mouse models of proteolipid protein (PLP)-related dysmyelination and demyelination. Brain Pathol 5(3):275-81. [PubMed: 8520727]  [MGI Ref ID J:31051]

Harsan L; Jalabi W; Grucker D; Ghandour MS. 2004. New insights on neuronal alterations in jimpy mutant brain. Neurochem Res 29(5):943-52. [PubMed: 15139292]  [MGI Ref ID J:106214]

Hatfield JS; Skoff RP. 1982. GFAP immunoreactivity reveals astrogliosis in females heterozygous for jimpy. Brain Res 250(1):123-31. [PubMed: 6291720]  [MGI Ref ID J:6895]

Hudson LD; Berndt JA; Puckett C; Kozak CA; Lazzarini RA. 1987. Aberrant splicing of proteolipid protein mRNA in the dysmyelinating jimpy mutant mouse. Proc Natl Acad Sci U S A 84(5):1454-8. [PubMed: 3469678]  [MGI Ref ID J:20245]

Ikenaka K; Furuichi T; Iwasaki Y; Moriguchi A; Okano H; Mikoshiba K. 1988. Myelin proteolipid protein gene structure and its regulation of expression in normal and jimpy mutant mice. J Mol Biol 199(4):587-96. [PubMed: 2451027]  [MGI Ref ID J:9096]

Jacque C; Delassalle A; Raoul M; Baumann N. 1983. Myelin basic protein deposition in the optic and sciatic nerves of dysmyelinating mutants quaking, jimpy, Trembler, mld, and shiverer during development. J Neurochem 41(5):1335-40. [PubMed: 6194264]  [MGI Ref ID J:12030]

Jacque C; Lachapelle F; Collier P; Raoul M; Baumann N. 1980. Accumulation of GFA, the monomeric precursor of the gliofilaments, during development in normal mice and dysmyelinating mutants. J Neurosci Res 5(5):379-85. [PubMed: 7192321]  [MGI Ref ID J:159595]

Jenkins SM; Bennett V. 2002. Developing nodes of Ranvier are defined by ankyrin-G clustering and are independent of paranodal axoglial adhesion. Proc Natl Acad Sci U S A 99(4):2303-8. [PubMed: 11842202]  [MGI Ref ID J:109527]

Johnson RS; Roder JC; Riordan JR. 1995. Over-expression of the DM-20 myelin proteolipid causes central nervous system demyelination in transgenic mice. J Neurochem 64(3):967-76. [PubMed: 7532214]  [MGI Ref ID J:24069]

Kagawa T; Ikenaka K; Inoue Y; Kuriyama S; Tsujii T; Nakao J; Nakajima K; Aruga J; Okano H; Mikoshiba K. 1994. Glial cell degeneration and hypomyelination caused by overexpression of myelin proteolipid protein gene. Neuron 13(2):427-42. [PubMed: 7520255]  [MGI Ref ID J:81165]

Kagawa T; Nakao J; Yamada M; Shimizu K; Hayakawa T; Mikoshiba K; Ikenaka K. 1994. Fate of jimpy-type oligodendrocytes in jimpy heterozygote. J Neurochem 62(5):1887-93. [PubMed: 7512620]  [MGI Ref ID J:18263]

Knapp PE; Adjan VV; Hauser KF. 2009. Cell-specific loss of kappa-opioid receptors in oligodendrocytes of the dysmyelinating jimpy mouse. Neurosci Lett 451(2):114-8. [PubMed: 19110031]  [MGI Ref ID J:146365]

Knapp PE; Bartlett WP; Williams LA; Yamada M; Ikenaka K; Skoff RP. 1999. Programmed cell death without DNA fragmentation in the jimpy mouse: secreted factors can enhance survival. Cell Death Differ 6(2):136-45. [PubMed: 10200560]  [MGI Ref ID J:53665]

Knapp PE; Benjamins JA; Skoff RP. 1996. Epigenetic factors up-regulate expression of myelin proteins in the dysmyelinating jimpy mutant mouse. J Neurobiol 29(2):138-50. [PubMed: 8821173]  [MGI Ref ID J:31558]

Knapp PE; Dutta S; Skoff RP. 1990. Differences in levels of neuroglial cell death in jimpy male mice and carrier females. Dev Neurosci 12(3):145-52. [PubMed: 2364893]  [MGI Ref ID J:116371]

Knapp PE; Ismaili S; Hauser KF; Ghandour MS. 1999. Abnormal Ca(2+) regulation in oligodendrocytes from the dysmyelinating jimpy mouse. Brain Res 847(2):332-7. [PubMed: 10575104]  [MGI Ref ID J:58599]

Knapp PE; Skoff RP. 1993. Jimpy mutation affects astrocytes: lengthening of the cell cycle in vitro. Dev Neurosci 15(1):31-6. [PubMed: 8269866]  [MGI Ref ID J:116364]

Kopmels B; Wollman EE; Guastavino JM; Delhaye-Bouchaud N; Fradelizi D; Mariani J. 1990. Interleukin-1 hyperproduction by in vitro activated peripheral macrophages from cerebellar mutant mice. J Neurochem 55(6):1980-5. [PubMed: 2230805]  [MGI Ref ID J:28095]

Kosaras B; Kirschner DA. 1990. Radial component of CNS myelin: junctional subunit structure and supramolecular assembly. J Neurocytol 19(2):187-99. [PubMed: 2113569]  [MGI Ref ID J:121320]

Kuchler S; Zanetta JP; Zaepfel M; Badache A; Sarlieve LL; Gumpel M; Baumann N; Vincendon G. 1990. Endogenous cerebellar soluble lectin and its ligands in central nervous system myelin of quaking and jimpy mutant mice. Dev Neurosci 12(6):382-97. [PubMed: 2076671]  [MGI Ref ID J:116788]

Lachapelle F; Gumpel M; Baumann N. 1994. Contribution of transplantations to the understanding of the role of the PLP gene. Neurochem Res 19(8):1083-90. [PubMed: 7528353]  [MGI Ref ID J:19842]

Lachapelle F; Lapie P; Campagnoni AT; Gumpel M. 1991. Oligodendrocytes of the jimpy phenotype can be partially restored by environmental factors in vivo. J Neurosci Res 29(2):235-43. [PubMed: 1890702]  [MGI Ref ID J:27477]

Lachapelle F; Lapie P; Gumpel M. 1992. Oligodendrocytes from jimpy and normal mature tissue can be 'activated' when transplanted in a newborn environment. Dev Neurosci 14(2):105-13. [PubMed: 1396170]  [MGI Ref ID J:3029]

Le Goascogne C; Eychenne B; Tonon MC; Lachapelle F; Baumann N; Robel P. 2000. Neurosteroid progesterone is up-regulated in the brain of jimpy and shiverer mice. Glia 29(1):14-24. [PubMed: 10594919]  [MGI Ref ID J:78788]

Li WX; Kuchler S; Zaepfel M; Badache A; Thomas D; Vincendon G; Baumann N; Zanetta JP. 1993. Cerebellar soluble lectin and its glycoprotein ligands in the developing brain of control and dysmyelinating mutant mice. Neurochem Int 22(2):125-33. [PubMed: 8439766]  [MGI Ref ID J:4577]

Macklin WB; Gardinier MV; King KD; Kampf K. 1987. An AG----GG transition at a splice site in the myelin proteolipid protein gene in jimpy mice results in the removal of an exon. FEBS Lett 223(2):417-21. [PubMed: 2444462]  [MGI Ref ID J:42979]

Mateu L; Luzzati V; Vonasek E; Borgo M; Lachapelle F. 1996. Order-disorder phenomena in myelinated nerve sheaths. VI. The effects of quaking, jimpy and shiverer mutations: an X-ray scattering study of mouse sciatic and optic nerves. J Mol Biol 256(2):319-29. [PubMed: 8594199]  [MGI Ref ID J:31918]

Mathis C; Denisenko-Nehrbass N; Girault JA; Borrelli E. 2001. Essential role of oligodendrocytes in the formation and maintenance of central nervous system nodal regions. Development 128(23):4881-90. [PubMed: 11731467]  [MGI Ref ID J:72956]

Matthieu JM; Widmer S; Herschkowitz. 1973. Jimpy, an anomaly of, myelin maturation. Biochemical study of myelination phases. Brain Res 55(2):403-12. [PubMed: 4123465]  [MGI Ref ID J:5352]

Meier C; Bischoff A. 1974. Dysmyelination in jimpy mouse. Electron microscopic study. J Neuropathol Exp Neurol 33(3):343-53. [PubMed: 4835113]  [MGI Ref ID J:5461]

Meier C; Bischoff A. 1975. Oligodendroglial cell development in jimpy mice and controls. An electron-microscopic study in the optic nerve. J Neurol Sci 26(4):517-28. [PubMed: 1206429]  [MGI Ref ID J:5611]

Meier C; Herschkowitz N; Bischoff A. 1974. Morphological and biochemical observations in the Jimpy spinal cord. Acta Neuropathol (Berl) 27(4):349-62. [PubMed: 4366515]  [MGI Ref ID J:5465]

Mikoshiba K; Kohsaka S; Hayakawa T; Takamatsu K; Tsukada Y. 1985. Immunohistochemical localization of 2',3'-cyclic nucleotide 3'-phosphodiesterase and myelin basic protein in the central nervous system of the jimpy and the normal mouse. J Neurochem 44(3):686-91. [PubMed: 2579194]  [MGI Ref ID J:7747]

Montague P; Dickinson PJ; McCallion AS; Stewart GJ; Savioz A ; Davies RW ; Kennedy PG ; Griffiths IR. 1997. Developmental expression of the murine Mobp gene. J Neurosci Res 49(2):133-43. [PubMed: 9272636]  [MGI Ref ID J:42121]

Moriguchi A; Ikenaka K; Furuichi T; Okano H; Iwasaki Y; Mikoshiba K. 1987. The fifth exon of the myelin proteolipid protein-coding gene is not utilized in the brain of jimpy mutant mice. Gene 55(2-3):333-7. [PubMed: 2444499]  [MGI Ref ID J:20094]

Murad S; Kishimoto Y. 1975. Alpha hydroxylation of lignoceric acid to cerebronic acid during brain development. Diminished hydroxylase activity in myelin-deficient mouse mutants. J Biol Chem 250(15):5841-6. [PubMed: 1150661]  [MGI Ref ID J:106960]

Nadon NL; Arnheiter H; Hudson LD. 1994. A combination of PLP and DM20 transgenes promotes partial myelination in the jimpy mouse. J Neurochem 63(3):822-33. [PubMed: 7519661]  [MGI Ref ID J:19774]

Nave KA; Bloom FE; Milner RJ. 1987. A single nucleotide difference in the gene for myelin proteolipid protein defines the jimpy mutation in mouse. J Neurochem 49(6):1873-7. [PubMed: 2445921]  [MGI Ref ID J:42978]

Nave KA; Lai C; Bloom FE; Milner RJ. 1986. Jimpy mutant mouse: a 74-base deletion in the mRNA for myelin proteolipid protein and evidence for a primary defect in RNA splicing. Proc Natl Acad Sci U S A 83(23):9264-8. [PubMed: 3466187]  [MGI Ref ID J:8514]

Nishiyama A. 1998. Glial progenitor cells in normal and pathological states. Keio J Med 47(4):205-8. [PubMed: 9884514]  [MGI Ref ID J:53266]

Omlin FX; Bischoff A; Moor H. 1980. Myelin and glial membrane structures in the optic nerve of normal and jimpy mouse J Neuropathol Exp Neurol 39(3):215-31.  [MGI Ref ID J:159601]

Ono J; Harada K; Takahashi M; Maeda M; Ikenaka K; Sakurai K; Sakai N; Kagawa T; Fritz-Zieroth B; Nagai T; Nihei A; Hashimoto S; Okada S. 1995. Differentiation between dysmyelination and demyelination using magnetic resonance diffusional anisotropy. Brain Res 671(1):141-8. [PubMed: 7728526]  [MGI Ref ID J:22996]

Peyron F; Timsit S; Thomas JL; Kagawa T; Ikenaka K; Zalc B. 1997. In situ expression of PLP/DM-20, MBP, and CNP during embryonic and postnatal development of the jimpy mutant and of transgenic mice overexpressing PLP. J Neurosci Res 50(2):190-201. [PubMed: 9373029]  [MGI Ref ID J:44118]

Phillips RJS. 1954. Jimpy, a new totally sexlinked gene in the house mouse. Z Indukt Abstamm Vererbungsl 86(3):322-6. [PubMed: 14360249]  [MGI Ref ID J:288]

Rawal N; Lee YJ; Paik WK; Kim S. 1992. Studies on NG-methylarginine derivatives in myelin basic protein from developing and mutant mouse brain. Biochem J 287(Pt 3):929-35. [PubMed: 1280107]  [MGI Ref ID J:3367]

Readhead C; Schneider A; Griffiths I; Nave KA. 1994. Premature arrest of myelin formation in transgenic mice with increased proteolipid protein gene dosage. Neuron 12(3):583-95. [PubMed: 7512350]  [MGI Ref ID J:17373]

SIDMAN RL; DICKIE MM; APPEL SH. 1964. MUTANT MICE (QUAKING AND JIMPY) WITH DEFICIENT MYELINATION IN THE CENTRAL NERVOUS SYSTEM. Science 144:309-11. [PubMed: 14169723]  [MGI Ref ID J:13141]

Schneider AM; Griffiths IR; Readhead C; Nave KA. 1995. Dominant-negative action of the jimpy mutation in mice complemented with an autosomal transgene for myelin proteolipid protein. Proc Natl Acad Sci U S A 92(10):4447-51. [PubMed: 7538670]  [MGI Ref ID J:25201]

Sinclair A; Raz Y; Kirschner DA; Villa-Komaroff L; Wolf MK; Billings-Gagliardi S. 1991. Shiverer jimpy double mutant mice. V. Correlation of genotype and myelin proteins. Dev Neurosci 13(3):138-42. [PubMed: 1721567]  [MGI Ref ID J:2529]

Skoff RP; Ghandour MS. 1995. Oligodendrocytes in female carriers of the jimpy gene make more myelin than normal oligodendrocytes. J Comp Neurol 355(1):124-33. [PubMed: 7636008]  [MGI Ref ID J:24977]

Sorg BA; Smith MM; Campagnoni AT. 1987. Developmental expression of the myelin proteolipid protein and basic protein mRNAs in normal and dysmyelinating mutant mice. J Neurochem 49(4):1146-54. [PubMed: 2442307]  [MGI Ref ID J:28225]

Suneja SK; Nagi MN; Cook L; Cinti DL. 1991. Decreased long-chain fatty acyl CoA elongation activity in quaking and jimpy mouse brain: deficiency in one enzyme or multiple enzyme activities? J Neurochem 57(1):140-6. [PubMed: 2051161]  [MGI Ref ID J:160743]

Thomson CE; Anderson TJ; McCulloch MC; Dickinson P; Vouyiouklis DA; Griffiths IR. 1999. The early phenotype associated with the jimpy mutation of the proteolipid protein gene. J Neurocytol 28(3):207-21. [PubMed: 10617903]  [MGI Ref ID J:60081]

Toda T; Hayakawa I; Matsubayashi Y; Tanaka K; Ikenaka K; Lu QR; Kawasaki H. 2008. Termination of lesion-induced plasticity in the mouse barrel cortex in the absence of oligodendrocytes. Mol Cell Neurosci 39(1):40-9. [PubMed: 18588982]  [MGI Ref ID J:141900]

Vela Hernandez JM; Dalmau I; Gonzalez B; Castellano B. 1997. Abnormal expression of the proliferating cell nuclear antigen (PCNA) in the spinal cord of the hypomyelinated Jimpy mutant mice. Brain Res 747(1):130-9. [PubMed: 9042536]  [MGI Ref ID J:39032]

Vela JM; Dalmau I; Acarin L; Gonzalez B; Castellano B. 1995. Microglial cell reaction in the gray and white matter in spinal cords from jimpy mice. An enzyme histochemical study at the light and electron microscope level. Brain Res 694(1-2):287-98. [PubMed: 8974656]  [MGI Ref ID J:29237]

Vela JM; Gonzalez B; Castellano B. 1998. Understanding glial abnormalities associated with myelin deficiency in the jimpy mutant mouse. Brain Res Brain Res Rev 26(1):29-42. [PubMed: 9600623]  [MGI Ref ID J:47188]

Verity AN; Levine MS; Campagnoni AT. 1990. Gene expression in the jimpy mutant: evidence for fewer oligodendrocytes expressing myelin protein genes and impaired translocation of myelin basic protein mRNA. Dev Neurosci 12(6):359-72. [PubMed: 1706246]  [MGI Ref ID J:116372]

Vermeesch MK; Knapp PE; Skoff RP; Studzinski DM; Benjamins JA. 1990. Death of individual oligodendrocytes in jimpy brain precedes expression of proteolipid protein. Dev Neurosci 12(4-5):303-15. [PubMed: 1705211]  [MGI Ref ID J:116789]

Vouyiouklis DA; Barrie JA; Griffiths IR; Thomson CE. 2000. A proteolipid protein-specific pre-mRNA (Ppm-1) contains intron 3 and is up-regulated during myelination in the CNS. J Neurochem 74(3):940-8. [PubMed: 10693924]  [MGI Ref ID J:60320]

Weiner JA; Hecht JH; Chun J. 1998. Lysophosphatidic acid receptor gene vzg-1/lpA1/edg-2 is expressed by mature oligodendrocytes during myelination in the postnatal murine brain. J Comp Neurol 398(4):587-98. [PubMed: 9717712]  [MGI Ref ID J:49099]

Willard HF; Riordan JR. 1985. Assignment of the gene for myelin proteolipid protein to the X chromosome: implications for X-linked myelin disorders. Science 230(4728):940-2. [PubMed: 3840606]  [MGI Ref ID J:8082]

Williams WC 2nd; Gard AL. 1997. In vitro death of jimpy oligodendrocytes: correlation with onset of DM-20/PLP expression and resistance to oligodendrogliotrophic factors. J Neurosci Res 50(2):177-89. [PubMed: 9373028]  [MGI Ref ID J:44558]

Wolf MK; Holden AB. 1969. Tissue culture analysis of the inherited defect of central nervous system myelination in jimpy mice. J Neuropathol Exp Neurol 28(2):195-213. [PubMed: 5787429]  [MGI Ref ID J:5115]

Wolf MK; Kardon GB; Adcock LH; Billings-Gagliardi S. 1983. Hypomyelinated mutant mice. V. Relationship between jp and jpmsd re-examined on identical genetic backgrounds. Brain Res 271(1):121-9. [PubMed: 6883111]  [MGI Ref ID J:7157]

Wu Q; Miller RH; Ransohoff RM; Robinson S; Bu J; Nishiyama A. 2000. Elevated levels of the chemokine GRO-1 correlate with elevated oligodendrocyte progenitor proliferation in the jimpy mutant. J Neurosci 20(7):2609-17. [PubMed: 10729341]  [MGI Ref ID J:109469]

Health & husbandry

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Colony Maintenance

Breeding & HusbandryHemizygous EdaTa males can be identified by one day of age by the absence of post orbital bristle. They lack fur behind the ears and on the tail. EdaTa ?/+ + have stripes. EdaTa ?/EdaTa + and EdaTa ?/Y have no stripes, no hair behind the ears or on the tail, and often have a bent tail tip. ? Plp1jp/Y can be identified by 10 days of age with severe tremor in rear legs and by 20-30 days of age they die. EdaTa and Plp1jp are 15 cM apart on the X chromosome. Thus, the expected Mendelian ratios are as follows: 85% of EdaTa ?/+ + females prove to be EdaTa Plp1jp/+ +; 15% of EdaTa ?/EdaTa ? or + ?/+ + females prove to carry Plp1jp; 85% of EdaTa ?/Y males prove to carry Plp1jp; 15% of +?/Y males prove to carry Plp1jp.
Mating SystemTJL Breeding Scheme: progeny test; heterozygote x F1 TJL Breeding Summary: Ta ?/+ + female x B6CBACa-Aw-J F1 male. Females which yield Plpjp/Y males become proven Ta Plpjp/+ + breeders for colony maintenance.

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $3300.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $4290.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

General Supply Notes

  • View the complete collection of spontaneous mutants in the Mouse Mutant Resource.

Control Information

  Control
   Untyped from the colony
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

Important Note

This strain is heterozygous for Plp1jp and EdaTa maintained on the same X chromosome.

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.


See Terms of Use tab for General Terms and Conditions


The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
Ordering Information
JAX® Mice
Surgical and Preconditioning Services
JAX® Services
Customer Services and Support
Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
Technical Support Email Form

Terms of Use

Terms of Use


General Terms and Conditions


Contact information

General inquiries regarding Terms of Use

Contracts Administration

phone:207-288-6470

JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


(6.8)