Strain Name: |
B6CBACa Aw-J/A-we a Mafbkr/J |
|---|---|
Stock Number: |
000288 |
Availability: | Repository-Cryopreserved |
General Terms and Conditions |
| Former Name |
B6CBACa Aw-J/A-we a MafbKrml-kr/J (Changed: 15-DEC-04
) |
|
Krmlkr (Changed: 15-DEC-04
) | |
| Genes & Alleles | Aw-J; Mafb; Mafbkr; a; we; |
Product Information
Strain Details
Type JAX® GEMM® Strain - Mutant Strain Additional information on JAX® GEMM® Strains. Type JAX® GEMM® Strain - Radiation Induced Mutation Type JAX® GEMM® Strain - Spontaneous Mutation Species laboratory mouse Generation N16F2p
Gene & Allele Details
| Allele Symbol | Aw-J | ||
|---|---|---|---|
| Allele Name | white bellied agouti Jackson | ||
| Common Name(s) | AWJ; | ||
| Strain of Origin | C57BL/6J | ||
| Gene Symbol and Name | a, nonagouti | ||
| Chromosome | 2 | ||
| Gene Common Name(s) | AGSW; AGTI; AGTIL; ASP; As; MGC126092; MGC126093; SHEP9; agouti; agouti signal protein; agouti suppressor; | ||
| Allele Symbol | Mafbkr | ||
| Allele Name | kreisler | ||
| Common Name(s) | Krmlkr; MafbKrml-kr; | ||
| Gene Symbol and Name | Mafb, v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian) | ||
| Chromosome | 2 | ||
| Gene Common Name(s) | KRML; Kreisler; Kreisler (maf-related) leucine zipper protein; Krml; Krml1; MGC43127; b-maf; kr; kreisler; | ||
| General Note | In homozygotes both the bone and membranous labyrinths of the inner ear are very abnormal. The abnormality traces back to faulty segmentation of the neural tube in the region of the rhombencephalon in eight 3/4-day embryos, followed by degeneration of cells in the fourth rhombomere (J:13001). The abnormalities of the neural tube are thought to lead to an abnormal position of the ear vesicles, which in 9-day kreisler embryos are not directly in contact with the neural tube as they are in normal embryos. An imperfect capsule forms around the vesicle, and extracapsular cysts result from growth of the vesicle through gaps in the capsule. The cysts are often quite large and located under the brain (J:13001, J:15032). The lack of segmentation caudally from the boundary between rhombomere 3 (r3) and r4 is correlated to altered expression patterns for genes associated with segmentation development, such as Egr2 and Hoxa3 (J:1490) along with other Hox genes (J:4596). It is proposed that the kreisler mutant lacks r5 and r6, with the cells that should be included in these rhombomeres adopting an r4 character. The abnormal amount of cell death observed results from disposal of the excess of r4 cells (J:19631). The loss of two rhombomeres results in ectopicdevelopment of structures, e.g., the development of the hyoid bone from a second arch anlage rather than from the missing third arch structure as in normal mice (J:4596). Shortening of the cell cycle in otocysts of 11-day embryos has been described (J:5392). The abnormal behavior resulting from these defects is very similar to that of the degenerative group of circling mutants. Viability and fertility of Mafbkr/Mafbkr mice are less than normal. Males are more likely to breed than are females (J:13001). | ||
| Molecular Note | A chromosomal inversion approximately 0.8 +/- 0.8cM in length very near the Mafb gene. The effect of the inversion appears to be to abolish transcription from the Mafb gene, not by physical disruption of the transcribed sequences, but by separation froma putative regulatory element or introduction of an inhibitory element. [MGI Ref ID J:22020] | ||
| Allele Symbol | we | ||
| Allele Name | wellhaarig | ||
| Strain of Origin | Agnes Bluhm's stocks | ||
| General Note | Arose as a spontaneous mutation in the stocks of Agnes Bluhm. Homozygotes are fully fertile. They have curly whiskers at 2 to 3 days of age and a wavy first coat, most strongly evident between 10 and 21 days. In later coats the waviness is lost. The hairs have a lower average diameter then those of normal mice (J:208). we has been shown to be on Chr 2 closely linked to pallid (Pldn) and has been bred in coupling with Pldn (J:247) with no interaction between the two genes. However, Graff et al. (J:8296) reported a cross between we/we and pa/pa mice that produced F2 pallid wellhaarig offspring in much higher than expected frequency, all showing a severe skeletal abnormality and early death. The authors hypothesized that the effect was due to complementary action of genes in the pa-we segment and that the F2 pallid wellhaarig mice were pa we/pa + in genotype, accounting for the excess of this class in the F2. Why the results of this cross differed from those of similar previous crosses is not clear. | ||
Genotyping Protocols
Aw-J
Related Strains
Inversions
View Inversions (47 strains)
000419 B10.UW-H3b we Pax1un at/SnJ 000065 B6C3Fe a/a-we Pax1un at/J
003656 AKR/J-we4J/J 000475 B10.129-weBkr/CyJ
Research Applications
This mouse can be used to support research in many areas including:Mafbkr related
we relatedDevelopmental Biology Research
Neural Tube Defects
Neurobiology Research
Neural Tube Defects
Vestibular and Hearing Defects
Sensorineural Research
Vestibular and Hearing Defects
Dermatology Research
Skin and Hair Texture Defects
References
Additional ReferencesPrice and Supply Information
| Strain Name: | B6CBACa Aw-J/A-we a Mafbkr/J |
| Stock Number: | 000288 |
Price Details
IMPORTANT NOTE: Prices are based on shipping destination. To view prices, select your shipping destination.
*NO Shipping Destination selected!
Supply Details
| Standard Supply | Repository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information. |
|---|---|
| Supply Notes |
Cryorecovery - Standard. The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two males and two females (two pairs) will be provided, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the delivery time to approximately 25 weeks. At least one member of each pair will be of known genotype and will carry the mutation if it is a mutant strain. Please note that pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Price represents a repository maintenance fee, which includes the cost of recovery of the strain from the cryopreservation resource and the periodic replacement of the frozen embryos used for recovery. Cryorecovery to establish a Dedicated Supply for greater quantities of mice. |
| Licensing | See General Terms and Conditions below |
General Terms and Conditions
View JAX® Mice & Services Conditions of Use.
The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
Purchasing Information
JAX® Mice Orders
Surgical Services
Contact Information
Orders & Technical Support
Tel: 800.422.6423 or 207.288.5845
Fax: 207.288.6150
Technical Support Email Form