| |||||||||||
- Description
- Phenotype
- Genes & alleles
- Genotyping
- Health & husbandry
- References
- Purchasing information
- Terms of Use
Description
The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.
Strain Information
Former Names B6CBACa Aw-J/A-we a MafbKrml-kr/J (Changed: 15-DEC-04 ) Krmlkr (Changed: 15-DEC-04 ) Type Mutant Strain; Radiation Induced Mutation; Spontaneous Mutation; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Species laboratory mouse Generation N16F2p
Related Strains
Inversions
View Inversions (48 strains)
000419 B10.UW-H3b we Pax1un at/SnJ 000065 B6C3Fe a/a-we Pax1un at/J
003656 AKR/J-we4J/J 000475 B10.129-weBkr/CyJ
Phenotype
Phenotype Information
assigned by genotype
The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.
we/we
Background Not Specified
- touch/vibrissae phenotype
- curly vibrissae (MGI Ref ID J:208)
- curly whiskers are evident shortly after birth
- skin/coat/nails phenotype
- thin hair shaft (MGI Ref ID J:208)
- smaller average diameter hair shaft than normal
- waved hair (MGI Ref ID J:208)
- the coat comes in very wavy, the wave most apparent between 10 and 21 days of age, then the wave decreases with age
This mouse can be used to support research in many areas including:Mafbkr related
we relatedDevelopmental Biology Research
Neural Tube Defects
Neurobiology Research
Neural Tube Defects
Vestibular and Hearing Defects
Sensorineural Research
Vestibular and Hearing Defects
Dermatology Research
Skin and Hair Texture Defects
Genes & Alleles
Gene & Allele Information
| Allele Symbol | Aw-J | ||
|---|---|---|---|
| Allele Name | white bellied agouti Jackson | ||
| Allele Type | Spontaneous | ||
| Common Name(s) | AWJ; | ||
| Strain of Origin | C57BL/6J | ||
| Gene Symbol and Name | a, nonagouti | ||
| Chromosome | 2 | ||
| Gene Common Name(s) | AGSW; AGTI; AGTIL; ASP; As; MGC126092; MGC126093; SHEP9; agouti; agouti signal protein; agouti suppressor; | ||
| Allele Symbol | Mafbkr | ||
| Allele Name | kreisler | ||
| Allele Type | Radiation induced | ||
| Common Name(s) | Krmlkr; MafbKrml-kr; | ||
| Gene Symbol and Name | Mafb, v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian) | ||
| Chromosome | 2 | ||
| Gene Common Name(s) | KRML; Kreisler; Kreisler (maf-related) leucine zipper protein; Krml; Krml1; MGC43127; b-maf; kr; kreisler; | ||
| General Note | In homozygotes both the bone and membranous labyrinths of the inner ear are very abnormal. The abnormality traces back to faulty segmentation of the neural tube in the region of the rhombencephalon in eight 3/4-day embryos, followed by degeneration of cells in the fourth rhombomere (J:13001). The abnormalities of the neural tube are thought to lead to an abnormal position of the ear vesicles, which in 9-day kreisler embryos are not directly in contact with the neural tube as they are in normal embryos. An imperfect capsule forms around the vesicle, and extracapsular cysts result from growth of the vesicle through gaps in the capsule. The cysts are often quite large and located under the brain (J:13001, J:15032). The lack of segmentation caudally from the boundary between rhombomere 3 (r3) and r4 is correlated to altered expression patterns for genes associated with segmentation development, such as Egr2 and Hoxa3 (J:1490) along with other Hox genes (J:4596). It is proposed that the kreisler mutant lacks r5 and r6, with the cells that should be included in these rhombomeres adopting an r4 character. The abnormal amount of cell death observed results from disposal of the excess of r4 cells (J:19631). The loss of two rhombomeres results in ectopicdevelopment of structures, e.g., the development of the hyoid bone from a second arch anlage rather than from the missing third arch structure as in normal mice (J:4596). Shortening of the cell cycle in otocysts of 11-day embryos has been described (J:5392). The abnormal behavior resulting from these defects is very similar to that of the degenerative group of circling mutants. Viability and fertility of Mafbkr/Mafbkr mice are less than normal. Males are more likely to breed than are females (J:13001). | ||
| Molecular Note | A chromosomal inversion approximately 0.8 +/- 0.8cM in length very near the Mafb gene. The effect of the inversion appears to be to abolish transcription from the Mafb gene, not by physical disruption of the transcribed sequences, but by separation froma putative regulatory element or introduction of an inhibitory element. [MGI Ref ID J:22020] | ||
| Allele Symbol | we | ||
| Allele Name | wellhaarig | ||
| Allele Type | Spontaneous | ||
| Strain of Origin | Agnes Bluhm's stocks | ||
| Gene Symbol and Name | we, wellhaarig | ||
| Chromosome | 2 | ||
Genotyping
Genotyping Information
This strain will not have a genotyping protocol or one is not currently available.
Helpful Links
Genotyping resources and troubleshooting
References
References
Additional References
Cordes SP; Barsh GS. 1994. The mouse segmentation gene kr encodes a novel basic domain-leucine zipper transcription factor. Cell 79(6):1025-34. [PubMed: 8001130] [MGI Ref ID J:22020]
McKay IJ; Muchamore I; Krumlauf R; Maden M; Lumsden A; Lewis J. 1994. The kreisler mouse: a hindbrain segmentation mutant that lacks two rhombomeres. Development 120(8):2199-211. [PubMed: 7925021] [MGI Ref ID J:19631]
Aw-J relatedMafbkr relatedAberg T; Wang XP; Kim JH; Yamashiro T; Bei M; Rice R; Ryoo HM; Thesleff I. 2004. Runx2 mediates FGF signaling from epithelium to mesenchyme during tooth morphogenesis. Dev Biol 270(1):76-93. [PubMed: 15136142] [MGI Ref ID J:92174]
Barsh GS; Epstein CJ. 1989. Physical and genetic characterization of a 75-kilobase deletion associated with al, a recessive lethal allele at the mouse agouti locus. Genetics 121(4):811-8. [PubMed: 2566558] [MGI Ref ID J:9799]
Baurle J; Vogten H; Grusser-Cornehls U. 1998. Course and targets of the calbindin D-28k subpopulation of primary vestibular afferents. J Comp Neurol 402(1):111-28. [PubMed: 9831049] [MGI Ref ID J:118430]
Boran T; Lesot H; Peterka M; Peterkova R. 2005. Increased apoptosis during morphogenesis of the lower cheek teeth in tabby/EDA mice. J Dent Res 84(3):228-33. [PubMed: 15723861] [MGI Ref ID J:112546]
Chinta SJ; Rane A; Yadava N; Andersen JK; Nicholls DG; Polster BM. 2009. Reactive oxygen species regulation by AIF- and complex I-depleted brain mitochondria. Free Radic Biol Med 46(7):939-47. [PubMed: 19280713] [MGI Ref ID J:145908]
Cui CY; Hashimoto T; Grivennikov SI; Piao Y; Nedospasov SA; Schlessinger D. 2006. Ectodysplasin regulates the lymphotoxin-beta pathway for hair differentiation. Proc Natl Acad Sci U S A 103(24):9142-7. [PubMed: 16738056] [MGI Ref ID J:111051]
Cui CY; Kunisada M; Esibizione D; Grivennikov SI; Piao Y; Nedospasov SA; Schlessinger D. 2007. Lymphotoxin-beta regulates periderm differentiation during embryonic skin development. Hum Mol Genet 16(21):2583-90. [PubMed: 17673451] [MGI Ref ID J:129949]
Dickie MM. 1969. Mutations at the agouti locus in the mouse. J Hered 60(1):20-5. [PubMed: 5798139] [MGI Ref ID J:30922]
Esibizione D; Cui CY; Schlessinger D. 2008. Candidate EDA targets revealed by expression profiling of primary keratinocytes from Tabby mutant mice. Gene 427(1-2):42-6. [PubMed: 18848976] [MGI Ref ID J:143603]
Granholm DE; Reese RN; Granholm NH. 1996. Agouti alleles alter cysteine and glutathione concentrations in hair follicles and serum of mice (A y/a, A wJ/A wJ, and a/a). J Invest Dermatol 106(3):559-63. [PubMed: 8648194] [MGI Ref ID J:32132]
Granholm DE; Reese RN; Granholm NH. 1995. Agouti alleles influence thiol concentrations in hair follicles and extrafollicular tissues of mice (Ay/a, AwJ/AwJ, a/a). Pigment Cell Res 8(6):302-6. [PubMed: 8789738] [MGI Ref ID J:31403]
Jones JM; Huang JD; Mermall V; Hamilton BA; Mooseker MS; Escayg A; Copeland NG; Jenkins NA; Meisler MH. 2000. The mouse neurological mutant flailer expresses a novel hybrid gene derived by exon shuffling between Gnb5 and Myo5a. Hum Mol Genet 9(5):821-8. [PubMed: 10749990] [MGI Ref ID J:61324]
Kappenman KE; Dvoracek MA; Harvison GA; Fuller BB; Granholm NH. 1992. Tyrosinase abundance and activity in murine hairbulb melanocytes of agouti mutants (C57BL/6J-a/a, Ay/a, and AwJ/AwJ). Pigment Cell Res Suppl 2:79-83. [PubMed: 1409442] [MGI Ref ID J:1295]
Katoh A; Yoshida T; Himeshima Y; Mishina M; Hirano T. 2005. Defective control and adaptation of reflex eye movements in mutant mice deficient in either the glutamate receptor delta2 subunit or Purkinje cells. Eur J Neurosci 21(5):1315-26. [PubMed: 15813941] [MGI Ref ID J:101081]
Knapp PE; Adjan VV; Hauser KF. 2009. Cell-specific loss of kappa-opioid receptors in oligodendrocytes of the dysmyelinating jimpy mouse. Neurosci Lett 451(2):114-8. [PubMed: 19110031] [MGI Ref ID J:146365]
Lee M; Kim A; Chua SC Jr; Obici S; Wardlaw SL. 2007. Transgenic MSH overexpression attenuates the metabolic effects of a high-fat diet. Am J Physiol Endocrinol Metab 293(1):E121-31. [PubMed: 17374695] [MGI Ref ID J:126508]
Lu W; Tsirka SE. 2002. Partial rescue of neural apoptosis in the Lurcher mutant mouse through elimination of tissue plasminogen activator. Development 129(8):2043-50. [PubMed: 11934869] [MGI Ref ID J:111363]
Mayer TC; Fishbane JL. 1972. Mesoderm-ectoderm interaction in the production of the agouti pigmentation pattern in mice. Genetics 71(2):297-303. [PubMed: 4558326] [MGI Ref ID J:5288]
Mitsumori K; Yasuhara K; Mori I; Hayashi S; Shimo T; Onodera H; Nomura T; Hayashi Y. 1998. Pulmonary fibrosis caused by N-methyl-N-nitrosourethane inhibits lung tumorigenesis by urethane in transgenic mice carrying the human prototype c-Ha-ras gene. Cancer Lett 129(2):181-90. [PubMed: 9719460] [MGI Ref ID J:52138]
Monroe DG; Wipf LP; Diggins MR; Matthees DP; Granholm NH. 1998. Agouti-related maturation and tissue distribution of alpha-Melanocyte Stimulating Hormone in wild-type (AwJ/AwJ) and mutant (Ay/a,a/a) mice. Pigment Cell Res 11(5):310-3. [PubMed: 9877102] [MGI Ref ID J:52183]
Mullen RJ. 1974. A<w-J> - white-bellied agouti-J Mouse News Lett 50:38. [MGI Ref ID J:64104]
Mustonen T; Ilmonen M; Pummila M; Kangas AT; Laurikkala J; Jaatinen R; Pispa J; Gaide O; Schneider P; Thesleff I; Mikkola ML. 2004. Ectodysplasin A1 promotes placodal cell fate during early morphogenesis of ectodermal appendages. Development 131(20):4907-19. [PubMed: 15371307] [MGI Ref ID J:128256]
O'donnell SM; Hansberger MW; Connolly JL; Chappell JD; Watson MJ; Pierce JM; Wetzel JD; Han W; Barton ES; Forrest JC; Valyi-Nagy T; Yull FE; Blackwell TS; Rottman JN; Sherry B; Dermody TS. 2005. Organ-specific roles for transcription factor NF-kappaB in reovirus-induced apoptosis and disease. J Clin Invest 115(9):2341-2350. [PubMed: 16100570] [MGI Ref ID J:100906]
Peng J; Wu Z; Wu Y; Hsu M; Stevenson FF; Boonplueang R; Roffler-Tarlov SK; Andersen JK. 2002. Inhibition of caspases protects cerebellar granule cells of the weaver mouse from apoptosis and improves behavioral phenotype. J Biol Chem 277(46):44285-91. [PubMed: 12221097] [MGI Ref ID J:119427]
Peng J; Xie L; Stevenson FF; Melov S; Di Monte DA; Andersen JK. 2006. Nigrostriatal dopaminergic neurodegeneration in the weaver mouse is mediated via neuroinflammation and alleviated by minocycline administration. J Neurosci 26(45):11644-51. [PubMed: 17093086] [MGI Ref ID J:114943]
Poole TW. 1975. Dermal-epidermal interactions and the action of alleles at the agouti locus in the mouse. Dev Biol 42(2):203-10. [PubMed: 1090472] [MGI Ref ID J:5519]
Probst FJ; Cooper ML; Cheung SW; Justice MJ. 2008. Genotype, phenotype, and karyotype correlation in the XO mouse model of Turner Syndrome. J Hered 99(5):512-7. [PubMed: 18499648] [MGI Ref ID J:138994]
Smith DE; Xu SG. 2003. Ultrastructural organization of GABA-like immunoreactive profiles in the weaver substantia nigra. J Neurocytol 32(3):293-303. [PubMed: 14724391] [MGI Ref ID J:121345]
Vandenput L; Swinnen JV; Boonen S; Van Herck E; Erben RG; Bouillon R; Vanderschueren D. 2004. Role of the androgen receptor in skeletal homeostasis: the androgen-resistant testicular feminized male mouse model. J Bone Miner Res 19(9):1462-70. [PubMed: 15312246] [MGI Ref ID J:111491]
Wu Q; Miller RH; Ransohoff RM; Robinson S; Bu J; Nishiyama A. 2000. Elevated levels of the chemokine GRO-1 correlate with elevated oligodendrocyte progenitor proliferation in the jimpy mutant. J Neurosci 20(7):2609-17. [PubMed: 10729341] [MGI Ref ID J:109469]
Yamago G; Takata Y; Furuta I; Urase K; Momoi T; Huh N. 2001. Suppression of hair follicle development inhibits induction of sonic hedgehog, patched, and patched-2 in hair germs in mice. Arch Dermatol Res 293(9):435-41. [PubMed: 11758785] [MGI Ref ID J:116953]
Yoshida T; Katoh A; Ohtsuki G; Mishina M; Hirano T. 2004. Oscillating Purkinje neuron activity causing involuntary eye movement in a mutant mouse deficient in the glutamate receptor delta2 subunit. J Neurosci 24(10):2440-8. [PubMed: 15014119] [MGI Ref ID J:97010]
van Empel VP; Bertrand AT; van der Nagel R; Kostin S; Doevendans PA; Crijns HJ; de Wit E; Sluiter W; Ackerman SL; De Windt LJ. 2005. Downregulation of apoptosis-inducing factor in harlequin mutant mice sensitizes the myocardium to oxidative stress-related cell death and pressure overload-induced decompensation. Circ Res 96(12):e92-e101. [PubMed: 15933268] [MGI Ref ID J:110278]
we relatedAdam J; Haddon C; Lewis J; McKay I; Myat A. 1992. The deaf kreisler mouse: a hindbrain segmentation mutant Hered Deaf News 8:10-11. [MGI Ref ID J:1490]
Chatonnet F; del Toro ED; Voiculescu O; Charnay P; Champagnat J. 2002. Different respiratory control systems are affected in homozygous and heterozygous kreisler mutant mice. Eur J Neurosci 15(4):684-92. [PubMed: 11886449] [MGI Ref ID J:89413]
Choo D; Ward J; Reece A; Dou H; Lin Z; Greinwald J. 2006. Molecular mechanisms underlying inner ear patterning defects in kreisler mutants. Dev Biol 289(2):308-17. [PubMed: 16325169] [MGI Ref ID J:104329]
Cordes SP; Barsh GS. 1994. The mouse segmentation gene kr encodes a novel basic domain-leucine zipper transcription factor. Cell 79(6):1025-34. [PubMed: 8001130] [MGI Ref ID J:22020]
DEOL MS. 1964. THE ABNORMALITIES OF THE INNER EAR IN KREISLER MICE. J Embryol Exp Morphol 12:475-90. [PubMed: 14207033] [MGI Ref ID J:13001]
Deol MS. 1976. Deficiencies of the inner ear in the mouse and their origin Colloq Int (Collques Internationaux) C.N.R.S. 266:163-171. [MGI Ref ID J:136112]
Eichmann A; Grapin-Botton A; Kelly L; Graf T; Le Douarin NM; Sieweke M. 1997. The expression pattern of the mafB/kr gene in birds and mice reveals that the kreisler phenotype does not represent a null mutant. Mech Dev 65(1-2):111-22. [PubMed: 9256349] [MGI Ref ID J:42034]
Frohman MA; Martin GR; Cordes SP; Halamek LP; Barsh GS. 1993. Altered rhombomere-specific gene expression and hyoid bone differentiation in the mouse segmentation mutant, kreisler (kr). Development 117(3):925-36. [PubMed: 8100767] [MGI Ref ID J:4596]
Garel S; Garcia-Dominguez M; Charnay P. 2000. Control of the migratory pathway of facial branchiomotor neurones Development 127(24):5297-307. [PubMed: 11076752] [MGI Ref ID J:65601]
Hertwig P. 1944. Die Genese der Hirn- und Gehororganmissbildungen bei rontgenmutierten Kreisler-Mausen Z Mensch Vererb Konst 18:327-54. [MGI Ref ID J:15032]
Hertwig P. 1942. Neue Mutationen und Koppelungsgruppen bei der Hausmaus Z Indukt Abstamm Vererbungsl 80:220-246. [MGI Ref ID J:208]
Manzanares M; Trainor PA; Nonchev S; Ariza-McNaughton L; Brodie J; Gould A; Marshall H; Morrison A; Kwan CT; Sham MH; Wilkinson DG; Krumlauf R. 1999. The role of kreisler in segmentation during hindbrain development. Dev Biol 211(2):220-37. [PubMed: 10395784] [MGI Ref ID J:56427]
McKay IJ; Lewis J; Lumsden A. 1997. Organization and development of facial motor neurons in the kreisler mutant mouse. Eur J Neurosci 9(7):1499-506. [PubMed: 9240407] [MGI Ref ID J:43333]
McKay IJ; Lewis J; Lumsden A. 1996. The role of FGF-3 in early inner ear development: an analysis in normal and kreisler mutant mice. Dev Biol 174(2):370-8. [PubMed: 8631508] [MGI Ref ID J:32033]
McKay IJ; Muchamore I; Krumlauf R; Maden M; Lumsden A; Lewis J. 1994. The kreisler mouse: a hindbrain segmentation mutant that lacks two rhombomeres. Development 120(8):2199-211. [PubMed: 7925021] [MGI Ref ID J:19631]
Mechta-Grigoriou F; Giudicelli F; Pujades C; Charnay P; Yaniv M. 2003. c-jun regulation and function in the developing hindbrain. Dev Biol 258(2):419-31. [PubMed: 12798298] [MGI Ref ID J:83936]
Ruben RJ. 1973. Development and cell kinetics of the kreisler (kr-kr) mouse. Laryngoscope 83(9):1440-68. [PubMed: 4758758] [MGI Ref ID J:5392]
Vazquez-Echeverria C; Dominguez-Frutos E; Charnay P; Schimmang T; Pujades C. 2008. Analysis of mouse kreisler mutants reveals new roles of hindbrain-derived signals in the establishment of the otic neurogenic domain. Dev Biol 322(1):167-78. [PubMed: 18703040] [MGI Ref ID J:142115]
FALCONER DS. 1954. Linkage in the mouse: the sex-linked genes and Rough. Z Indukt Abstamm Vererbungsl 86(2):263-8. [PubMed: 13227156] [MGI Ref ID J:247]
Graff RJ; Simmons D; Meyer J; Martin-Morgan D; Kurtz M. 1986. Abnormal bone production associated with mutant mouse genes pa and we. J Hered 77(2):109-13. [PubMed: 3711636] [MGI Ref ID J:8296]
Hertwig P. 1942. Neue Mutationen und Koppelungsgruppen bei der Hausmaus Z Indukt Abstamm Vererbungsl 80:220-246. [MGI Ref ID J:208]
Koniukhov BV; Kupriianov SD. 1990. [The mutant gene wellhaarig disturbs the differentiation of hair follicle cells in the mouse] Ontogenez 21(1):56-62. [PubMed: 1694022] [MGI Ref ID J:153649]
Koniukhov BV; Malinina NA; Martynov MIu. 2004. [The we gene is a modifier of the wal gene in mice] Genetika 40(7):968-74. [PubMed: 15458208] [MGI Ref ID J:153574]
Koniukhov BV; Vsevolodov EB; Sazhina MV. 1993. [An ultrastructural analysis of the cells of the outer root sheath of the hair follicles in mice of the wellhaarig mutant strain] Ontogenez 24(1):96-102. [PubMed: 8474761] [MGI Ref ID J:153577]
Martynova MIu; Isaev DA; Koniukhov BV. 2002. [Effects of the mutant gene wellhaarig in chimeric mice] Genetika 38(11):1511-7. [PubMed: 12500677] [MGI Ref ID J:153575]
Sundberg JP (ed.). 1994. . In: Handbook of Mouse Mutations with Skin and Hair Abnormalities: Animal Models and Biomedical Tools. CRC Press, Boca Raton. [MGI Ref ID J:30359]
Health & husbandry
Health & Colony Maintenance Information
Currently there no information available for this strain. This may be due to the supply level of this strain.
Purchasing information
Pricing, Supply Level & Notes, Controls, General Terms & Conditions
Pricing
| Pricing for USA, Canada and Mexico shipping destinations |
|
Animals Provided
Price (US dollars $) Cryorecovery Fee $1900.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Additional Supply Details
| Pricing for International shipping destinations |
|
Animals Provided
Price (US dollars $) Cryorecovery Fee $2470.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Additional Supply Details
|
|
|
Supply Details
| Standard Supply | Cryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information. |
|---|---|
| Supply Notes |
|
Payment Terms and Conditions
Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.
See Terms of Use tab for General Terms and Conditions
The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
Purchasing Information
JAX® Mice Orders
Surgical Services
Contact Information
Orders & Technical Support
Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
Technical Support Email Form
Terms of Use
Terms of Use
General Terms and Conditions
Contact information
General inquiries
Contracts Administration
| phone: | 207-288-6470 |
| fax: | 207-288-6655 |
JAX® Mice, Products & Services Conditions of Use
"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.No Warranty
MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.
In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.
No Liability
In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. In purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.
MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.
The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.
Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.