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Strain Name:

B6C3Fe-a/a Hoxa13Hd Mcoln3Va-J/J

Stock Number:

000296

Availability:

Repository-Cryopreserved

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General Terms and Conditions

Former Name      B6C3Fe-a/a Hoxa13Hd McolnVa-J    (Changed: 15-DEC-04 )
      B6C3Fe-a/a-Hoxa13Hd McolnVa-J    (Changed: 15-DEC-04 )
      B6C3Fe-a/a-Hoxa13Hd VaJ    (Changed: 15-DEC-04 )
Genes & Alleles   Hoxa13;   Hoxa13Hd;   Mcoln3;   Mcoln3Va-J;   a;

Product Information

Strain Details

Type JAX® GEMM® Strain - Mutant Stock
Additional information on JAX® GEMM® Strains.
Type JAX® GEMM® Strain - Spontaneous Mutation
Specieslaboratory mouse
GenerationN53p

Appearance
Hoxa13Hd: black, toe defects to hindfeet
Related Genotype: a/a Hoxa13Hd/+ +/+

Mcoln3Va-J: slightly diluted black with spotting on belly or head, ataxic
Related Genotype: Mcoln3Va-J/+ +/+

Mcoln3Va-J: agouti, unaffected
Related Genotype: A/A +/+ +/+

Hoxa13Hd: black unaffected
Related Genotype: a/a +/+ +/+

Strain Description
Mice heterozygous for the varitint-waddler Jackson spontaneous mutation (Mcoln3Va-J) are more pigmented than the original varitint waddler mice (Mcoln3Va) and behave normally although they are deaf. They have slightly diluted coat color, a large irregular belly spot, and white feet and tail tip. Homozygous mutant mice have extensive white spotting interspersed with patches of diluted color. They are deaf but behave normally and are fertile. Compound heterozygotes of the two alleles (Mcoln3Va-J/Mcoln3Va) are similar to Mcoln3Va-J/Mcoln3Va-J mice but are smaller with more white spotting and abnormal behavior. They are deaf and circle vigorously. Viability and fertility of Mcoln3Va-J/Mcoln3Va mice are considerably reduced. This strain is also carrying the semidominant hypodactyly spontaneous mutation (Hoxa13Hd). Heterozygous hypodactyly mutant mice are viable and fertile. Heterozygotes are missing the terminal phalanx of the first digit of the hindfoot and show variable penetrance for shortening or missing first phalanx. The forefeet are normal. Homozygous mutant mice have a single digit on each foot and greatly reduced carpals, metacarpals, tarsals, and metatarsals. The surviving digit is probably the fifth. Most homozygotes die before birth, but a few have survived to maturity but are sterile.

Strain Development
The mutation hypodactyly (Hoxa13Hd) arose spontaneously in strain MYA/Hu of Dr. K. P. Hummel at The Jackson Laboratory in approximately 1965. It was backcrossed onto a hybrid of C3HeB/Hu x DBAfB/Hu for 5 generations before being backcrossed onto C57BL/6J for 7 generations. The mutation Mcoln3Va-J arose spontaneously in a chromosome 3 linkage testing stock and was backcrossed onto C57BL/6J for 10 generations before crossing to C57BL/6J-Hoxa13Hd/+ at N7. This Hoxa13Hd Mcoln3Va-J stock was sibling bred for 2 generations and backcrossed once to C57BL/6J and then crossed to the B6C3Fe-a/a F1 hybrid and maintained by continued crosses to this hybrid. In 1987 B6C3F1-a/a F1 females were bred with Hoxa13Hd Mcoln3Va-J/+ + males at N5F2 to generate embryos for cryopreservation.

Related Disease (OMIM) Terms

Hand-Foot-Uterus Syndrome
Mammalian Phenotype Terms assigned by genotype

Hoxa13Hd/Hoxa13+

        B6C3Fe-a/a Hoxa13Hd Mcoln3Va-J/J
  • endocrine/exocrine gland phenotype
  • abnormal sex gland morphology (MGI Ref ID J:54823)
    • decrease in the number of duct tips in the ampullary gland
    • abnormal coagulating gland morphology (MGI Ref ID J:54823)
      • 29% have one lobe of the coagulating gland duct that has a single main duct
    • abnormal seminal gland morphology (MGI Ref ID J:54823)
      • seminal vesicles have an altered curvature and spiked clefting and lack the secondary and tertiary branches
      • small seminal gland (MGI Ref ID J:54823)
        • 86% have seminal vesicles that are two thirds the size of wild type
    • decreased prostate duct number (MGI Ref ID J:54823)
      • decrease in the number of duct tips in the dorsal and lateral divisions of the dorsolateral prostate and the ventral prostate
    • small prostate (MGI Ref ID J:54823)
      • 57% have a smaller dorsal prostate, 43% have a smaller lateral prostate, and 43% have a smaller ventral prostate
      • small ventral prostate (MGI Ref ID J:54823)
        • 43% have a smaller ventral prostate
  • reproductive system phenotype
  • abnormal female reproductive anatomy (MGI Ref ID J:58731)
    • exhibit an anterior transformation of cervical tissue to a uterine stromal phenotype
  • abnormal sex gland morphology (MGI Ref ID J:54823)
    • decrease in the number of duct tips in the ampullary gland
    • abnormal coagulating gland morphology (MGI Ref ID J:54823)
      • 29% have one lobe of the coagulating gland duct that has a single main duct
    • abnormal seminal gland morphology (MGI Ref ID J:54823)
      • seminal vesicles have an altered curvature and spiked clefting and lack the secondary and tertiary branches
      • small seminal gland (MGI Ref ID J:54823)
        • 86% have seminal vesicles that are two thirds the size of wild type
    • decreased prostate duct number (MGI Ref ID J:54823)
      • decrease in the number of duct tips in the dorsal and lateral divisions of the dorsolateral prostate and the ventral prostate
    • small prostate (MGI Ref ID J:54823)
      • 57% have a smaller dorsal prostate, 43% have a smaller lateral prostate, and 43% have a smaller ventral prostate
      • small ventral prostate (MGI Ref ID J:54823)
        • 43% have a smaller ventral prostate

Hoxa13Hd/Hoxa13Hd

        B6C3Fe-a/a Hoxa13Hd Mcoln3Va-J/J
  • digestive/alimentary phenotype
  • intestinal obstruction (MGI Ref ID J:58731)
    • 2 of 3 males exhibit bowel obstructions
  • short perineum (MGI Ref ID J:58731)
    • 5 of 6 females exhibit a reduced ano-vaginal distance
  • renal/urinary system phenotype
  • abnormal urinary system morphology (MGI Ref ID J:58731)
    • one third of females exhibit urinary tract defects
    • abnormal penis morphology (MGI Ref ID J:58731)
      • the proximal part of the penian bone is smaller and mishapen
    • abnormal urethra morphology (MGI Ref ID J:58731)
      • urethra is abnormally located within the serosal layer in females
      • urethrovaginal fistula (MGI Ref ID J:58731)
        • 1 of 18 females exhibit an abnormal fistula connecting the bladder and vaginal cavity
    • abnormal urinary bladder morphology (MGI Ref ID J:58731)
      • 2 of 3 males exhibit cystic bladders
      • 1 of 18 females lack a bladder
      • urinary bladder hypoplasia (MGI Ref ID J:58731)
        • 1 of 3 males exhibit a hypoplastic bladder
    • kidney cysts (MGI Ref ID J:58731)
      • 3 of 18 females exhibit cystic kidneys
    • renal hypoplasia (MGI Ref ID J:58731)
      • 1 of 18 females exhibt a hypoplastic kidney
  • reproductive system phenotype
  • abnormal female reproductive anatomy (MGI Ref ID J:58731)
    • stromal tissue surrounding the cervical canals is smaller and the cervical canal is greatly reduced in size
    • the columnar-to-squamosal epithelial transition that characterizes mature cervical-vaginal tissue is poitioned within uterine-like stroma rather than cervical tissue
    • exhibit an anterior transformation of cervical tissue to a uterine stromal phenotype
    • abnormal cervix morphology (MGI Ref ID J:58731)
      • cervix is hypoplastic
    • abnormal uterus morphology (MGI Ref ID J:58731)
      • 5 of 18 females exhibit enlarged, fluid-filled uterine horns
    • abnormal vagina morphology (MGI Ref ID J:58731)
      • profoundly small vaginal cavity
      • urethrovaginal fistula (MGI Ref ID J:58731)
        • 1 of 18 females exhibit an abnormal fistula connecting the bladder and vaginal cavity
  • abnormal penis morphology (MGI Ref ID J:58731)
    • the proximal part of the penian bone is smaller and mishapen
  • female infertility (MGI Ref ID J:58731)
  • male infertility (MGI Ref ID J:58731)
  • short perineum (MGI Ref ID J:58731)
    • 5 of 6 females exhibit a reduced ano-vaginal distance

The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.

Mcoln3Va-J/Mcoln3+

        Background Not Specified
  • hearing/vestibular/ear phenotype
  • deafness (MGI Ref ID J:5286)
  • behavior/neurological phenotype
  • *normal* behavior/neurological phenotype (MGI Ref ID J:64107)
    • behave normally unlike Mcoln3Va
  • pigmentation phenotype
  • abnormal skin pigmentation (MGI Ref ID J:5286)
    • white feet
    • non-pigmented tail tip (MGI Ref ID J:5286)
  • belly spot (MGI Ref ID J:5286)
    • mice exhibit a large, irregular belly spot
  • diluted coat color (MGI Ref ID J:5286)
  • variegated coat color (MGI Ref ID J:64107)
    • a slightly dilute coat color, large irregular belly spots and white feet and tail tips
    • not as varicolored as unlike Mcoln3Va
  • skin/coat/nails phenotype
  • abnormal skin pigmentation (MGI Ref ID J:5286)
    • white feet
    • non-pigmented tail tip (MGI Ref ID J:5286)
  • belly spot (MGI Ref ID J:5286)
    • mice exhibit a large, irregular belly spot
  • diluted coat color (MGI Ref ID J:5286)
  • variegated coat color (MGI Ref ID J:64107)
    • a slightly dilute coat color, large irregular belly spots and white feet and tail tips
    • not as varicolored as unlike Mcoln3Va
  • limbs/digits/tail phenotype
  • non-pigmented tail tip (MGI Ref ID J:5286)

Mcoln3Va-J/Mcoln3Va-J

        Background Not Specified
  • hearing/vestibular/ear phenotype
  • deafness (MGI Ref ID J:5286)
  • behavior/neurological phenotype
  • *normal* behavior/neurological phenotype (MGI Ref ID J:64107)
    • both sexes are fertile and do not have the abnormal behavior of Mcoln3Va
    • able to swim
    • mice swim and behave normally
  • pigmentation phenotype
  • diluted coat color (MGI Ref ID J:5286)
  • variegated coat color (MGI Ref ID J:64107)
    • mostly white with patches of dilute color
  • white spotting (MGI Ref ID J:5286)
  • skin/coat/nails phenotype
  • diluted coat color (MGI Ref ID J:5286)
  • variegated coat color (MGI Ref ID J:64107)
    • mostly white with patches of dilute color
  • white spotting (MGI Ref ID J:5286)

Gene & Allele Details

Allele Symbol Hoxa13Hd
Allele Name hypodactyly
Common Name(s) Hd;
Strain of OriginMYA/Hu
Gene Symbol and Name Hoxa13, homeo box A13
Chromosome 6
Gene Common Name(s) HOX1; HOX1J; Hd; Hox-1.10; RGD1562483; homeo box-1 cluster, gene 10; hypodactyly;
General Note

A double mutant of the hydrocephalic-polydactyly mutation, hophpy, and the hypodactyly mutation, Hoxa13Hd, produced offspring of normal hallux phenotype. The first mutant tends to multiply, the second to eliminate halluces, and the two cancel each other (J:23839).

Molecular Note A 50-base pair deletion in the first exon of the Hd allele that probably arose from unequal recombination or misalignment between triplet repeats. [MGI Ref ID J:33715]
 
Allele Symbol Mcoln3Va-J
Allele Name varitint waddler Jackson
Common Name(s) VaJ;
Strain of OriginSTOCK Mcoln3
Gene Symbol and Name Mcoln3, mucolipin 3
Chromosome 3
Gene Common Name(s) 6720490O21Rik; FLJ11006; FLJ36629; MGC71509; RIKEN cDNA 6720490O21 gene; TRP-ML3; TRPML3; Va; varitint-waddler;
General Note This mutation was found in a linkage cross involving Mcoln3Va, and probably arose by mutation from Mcoln3Va. (J:5286)
Molecular Note This allele has a T-to-C transition at nucleotide 1085 within exon 8. This results in a change from isoleucine to threonine at amino acid 362 in the second extracellular loop. The Mcoln3Va-J allele, which arose on a strain segregating for the more severe Mcoln3Va allele, also has the G-to-C transversion at nucleotide 1255 specific to the Mcoln3Va allele indicating that the Mcoln3Va-J allele contains an additional point mutation to the Mcoln3Va allele. The less severe phenotype of the Mcoln3Va-J allele suggests that the T-to-C transition at nucleotide 1085 might mitigate the effects of the G-to-C mutation at nucleotide 1255 although the impact of genetic background must be considered. The encoded protein can be detected in the hair cells of heterozygous and homozygous mice. [MGI Ref ID J:80336]
 
Allele Symbol a
Allele Name nonagouti

Control Information

  Control
   Wild-type from the colony
 
  Considerations for Choosing Controls

Colony Maintenance

Breeding & HusbandryMcolnVa-J and Hoxa13Hd are on separate chromosomes and assort independently. The mice distributed are heterozygous carriers for either one or the other mutation, but not both.

Related Strains

Strains carrying   Mcoln3Va-J allele
000126   B6By.Cg-Sd Mcoln3Va-J Krt25Re/J
View Strains carrying   Mcoln3Va-J     (1 strain)

Strains carrying   a allele
003879   B10;TFLe-a/a T tf/+ tf/J
001538   B6 x B6C3Sn a/A-T(1;9)27H/J
000916   B6 x B6C3Sn a/A-T(5;12)31H/J
000602   B6 x B6C3Sn a/A-T(8;16)17H/J
000618   B6 x FSB/GnEi a/a Ctslfs/J
000577   B6 x STOCK a Oca2p Hps5ru2 Ednrbs/J
000601   B6 x STOCK a/a T(7;18)50H/J
000592   B6 x STOCK T(2;4)13H a/J
000001   B6.C3 A/a Mgrn1md/J
000785   B6;D2-a Es1e/J
000604   B6C3 a/A-T(10;13)199H +/+ Lystbg-J/J or Lystbg-2J/J
002807   B6C3Fe a/a-Meox2fla/J
000224   B6C3Fe a/a-Scyl1mdf/J
001037   B6C3Fe a/a-Agtpbp1pcd/J
000221   B6C3Fe a/a-Alx4lst-J/J
002062   B6C3Fe a/a-Atp7aMo-8J/J
001756   B6C3Fe a/a-Cacng2stg/J
001815   B6C3Fe a/a-Col1a2oim/J
000231   B6C3Fe a/a-Csf1op/J
000209   B6C3Fe a/a-Dh/J
000211   B6C3Fe a/a-Dstdt-J/J
000210   B6C3Fe a/a-Edardl-J/J
000207   B6C3Fe a/a-Edaraddcr/J
000182   B6C3Fe a/a-Eef1a2wst/J
001278   B6C3Fe a/a-Glra1spd/J
000241   B6C3Fe a/a-Glrbspa/J
002875   B6C3Fe a/a-Hoxd13spdh/J
000304   B6C3Fe a/a-Krt71Ca Scn8amed-J/J
000226   B6C3Fe a/a-Largemyd/J
000636   B6C3Fe a/a-Lmx1adr-J/J
001280   B6C3Fe a/a-Lse/J
001573   B6C3Fe a/a-MitfMi/J
001035   B6C3Fe a/a-Napahyh/J
000181   B6C3Fe a/a-Otogtwt/J
000278   B6C3Fe a/a-Papss2bm Hps1ep Hps6ru/J
000205   B6C3Fe a/a-Papss2bm/J
002078   B6C3Fe a/a-Pcdh15av-2J/J
000246   B6C3Fe a/a-Pitpnavb/J
001430   B6C3Fe a/a-Ptch1mes/J
000506   B6C3Fe a/a-Qkqk/J
000235   B6C3Fe a/a-Relnrl/J
000237   B6C3Fe a/a-Rorasg/J
000290   B6C3Fe a/a-Sox10Dom/J
000230   B6C3Fe a/a-Tcirg1oc/J
003612   B6C3Fe a/a-Trak1hyrt/J
001512   B6C3Fe a/a-Ttnmdm/J
001607   B6C3Fe a/a-Unc5crcm/J
000005   B6C3Fe a/a-Wc/J
000243   B6C3Fe a/a-Wnt1sw/J
000248   B6C3Fe a/a-Xpl/J
001750   B6C3Fe a/a-XsJ/J
000624   B6C3Fe a/a-anx/J
003020   B6C3Fe a/a-dep/J
002018   B6C3Fe a/a-din/J
002339   B6C3Fe a/a-nma/J
000240   B6C3Fe a/a-soc/J
000063   B6C3Fe a/a-sy/J
001055   B6C3Fe a/a-tip/J
000245   B6C3Fe a/a-tn/J
000019   B6C3Fe-a/a-Itpr1opt/J
001022   B6C3FeF1/J a/a
000971   B6EiC3 a/A-Och/J
000551   B6EiC3 a/A-Tbx15de-H/J
006450   B6EiC3 a/A-Vss/J
000557   B6EiC3-+ a/LnpUl A/J
000503   B6EiC3Sn a/A-Gy/J
001811   B6EiC3Sn a/A-Otcspf-ash/J
002343   B6EiC3Sn a/A-Otcspf/J
000391   B6EiC3Sn a/A-Pax6Sey-Dey/J
001924   B6EiC3Sn a/A-Ts(1716)65Dn
001923   B6EiC3Sn a/A-Ts(417)2Lws Tim/J
000225   C3FeLe.B6 a/a-Ptpn6me/J
000198   C3FeLe.B6-a/J
000291   C3FeLe.Cg-a/a Hm KitlSl Krt71Ca-J/J
001886   C3HeB/FeJLe a/a-gnd/J
000584   C57BL/6J-+ T(1;2)5Ca/a +/J
000284   CWD/LeJ
000670   DBA/1J
000671   DBA/2J
001057   HPT/LeJ
000260   JGBF/LeJ
000265   MY/HuLeJ
000308   SSL/LeJ
000994   STOCK a Myo5ad Mregdsu/J
000064   STOCK a Tyrp1b Sisi/J
002238   STOCK a Tyrp1b shmy/J
001433   STOCK a skt/J
000579   STOCK a tp/J
000319   STOCK a us/J
002648   STOCK a/a Cln6nclf/J
000317   STOCK a/a Egfrwa2/J
000302   STOCK a/a MitfMi-wh +/+ Itpr1opt/J
000286   STOCK a/a Myo5ad fd/+ +/J
000206   STOCK a/a Tyrc-h/J
001432   STOCK a/a Tyrp1b sks/Tyrp1b +/J
000281   STOCK a/a ma ft/ma ft/J
000312   STOCK stb + a/+ Fignfi a/J
000596   STOCK T(2;11)30H/+ x AEJ-a Gdf5bp-H/J or A/J-a Gdf5bp-J/J
000970   STOCK T(2;16)28H A/T(2;16)28H a/J
000590   STOCK T(2;4)1Sn a/J
000594   STOCK T(2;8)26H a/T(2;8)26H a Tyrp1+/Tyrp1b/J
000623   TR/DiEiJ
View Strains carrying   a     (102 strains)

Strains carrying other alleles of Mcoln3
000071   C57BL/6J-Mcoln3Va/J
000268   RSV/LeJ
View Strains carrying other alleles of Mcoln3     (2 strains)

Strains carrying other alleles of a
003301   (C57BL/6J x C3H-Eya1bor)F1/J
000251   AEJ.Cg-ae +/a Gdf5bp-H/J
000202   AEJ/Gn-bd/J
000199   AEJ/GnLeJ
000427   B10.CE-H13b Aw/(30NX)SnJ
000420   B10.LP-H13b Aw/Sn
000477   B10.PA-Pldnpa H3e at/SnJ
000419   B10.UW-H3b we Pax1un at/SnJ
000593   B6 x B6CBCa Aw-J/A-Grid2Lc T(2;6)7Ca MitfMi-wh/J
000502   B6 x B6CBCa Aw-J/A-Myo5aflr Gnb5flr/J
000599   B6 x B6CBCa Aw-J/A-T(5;13)264Ca KitW-v/J
002083   B6 x B6EiC3 a/A-T(7;16)235Dn/J
000507   B6 x B6EiC3 a/A-Otcspf/J
002016   B6(Cg)-Aw-J EdaTa-6J Chr YB6-Sxr/EiJ
000552   B6-Aw-J-EdaTa-6J.Cg-Sxr
001730   B6-Aw-J-EdaTa-6J.Cg-Sxrb Hya-/J
000841   B6-Aw-J.CBy-EdaTa-By/J
001809   B6-Aw-J.Cg-EdaTa-6J +/+ ArTfm/J
000600   B6-Gpi1b x B6CBCa Aw-J/A-T(7;15)9H Gpi1a/J
000769   B6.C/(HZ18)By-at-44J/J
000203   B6.C3-Aiy/a/J
000017   B6.C3Fe-Avy/J
000628   B6.CE-A Amy1b Amy2b/J
005505   B6.Cg-Ay Slc7a11sut/LmLlp
000021   B6.Cg-Ay/J
001572   B6.Cg-am-J/J
100409   B6129PF1/J-Aw-J/Aw
004200   B6;CBACa Aw-J/A-Npr2cn-2J/J
000505   B6C3 Aw-J/A-Mutedmu/J
000604   B6C3 a/A-T(10;13)199H +/+ Lystbg-J/J or Lystbg-2J/J
000065   B6C3Fe a/a-we Pax1un at/J
000314   B6CBACa Aw-J/A-EdaTa/J-XO
000501   B6CBACa Aw-J/A-Aifm1Hq/J
001046   B6CBACa Aw-J/A-Grid2Lc/J
000500   B6CBACa Aw-J/A-Gs/J
002703   B6CBACa Aw-J/A-Hydinhy3/J
000247   B6CBACa Aw-J/A-Kcnj6wv/J
000287   B6CBACa Aw-J/A-Plp1jp EdaTa/J
000515   B6CBACa Aw-J/A-SfnEr/J
000242   B6CBACa Aw-J/A-spc/J
000288   B6CBACa Aw-J/A-we a Mafbkr/J
001201   B6CBACaF1/J-Aw-J/A
001752   B6CBCa Aw-J/A-T(7;15)9H/J
006450   B6EiC3 a/A-Vss/J
000557   B6EiC3-+ a/LnpUl A/J
000504   B6EiC3Sn a/A-Cacnb4lh/J
000553   B6EiC3Sn a/A-Egfrwa2 Wnt3avt/J
001811   B6EiC3Sn a/A-Otcspf-ash/J
002343   B6EiC3Sn a/A-Otcspf/J
001923   B6EiC3Sn a/A-Ts(417)2Lws Tim/J
000200   C3FeB6 A/Aw-J-Ankank/J
000638   C3FeB6 A/Aw-J-Spnb4qv-J/J
001203   C3FeB6F1/J A/Aw-J
001272   C3H/HeSnJ-Ahvy/J
000099   C3HeB/FeJ-Avy/J
000338   C57BL/6J Aw-J-EdaTa-6J/J
000258   C57BL/6J-Ai/a/J
000774   C57BL/6J-Asy/a/J
000569   C57BL/6J-Aw-J-EdaTa +/+ ArTfm/J
000051   C57BL/6J-Aw-J/J
000055   C57BL/6J-at-33J/J
000070   C57BL/6J-atd/J
002468   KK.Cg-Ay/J
000262   LS/LeJ
000283   LT.CAST-A/J
001759   STOCK A Tyrc Sha/J
001427   STOCK Aw us/J
View Strains carrying other alleles of a     (67 strains)

Research Applications

This mouse can be used to support research in many areas including:

Hoxa13Hd related

Developmental Biology Research
Skeletal Defects

Mcoln3Va-J related

Dermatology Research
Color and White Spotting Defects

Neurobiology Research
Vestibular and Hearing Defects

Sensorineural Research
Vestibular and Hearing Defects

References

Additional References

Price and Supply Information

Strain Name: B6C3Fe-a/a Hoxa13Hd Mcoln3Va-J/J
Stock Number: 000296

Price Details

IMPORTANT NOTE: Prices are based on shipping destination. To view prices, select your shipping destination.

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Supply Details

Standard SupplyRepository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information.
Supply Notes Cryorecovery - Standard.
The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two males and two females (two pairs) will be provided, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the delivery time to approximately 25 weeks. At least one member of each pair will be of known genotype and will carry the mutation if it is a mutant strain. Please note that pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Price represents a repository maintenance fee, which includes the cost of recovery of the strain from the cryopreservation resource and the periodic replacement of the frozen embryos used for recovery.

Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
One to two pairs will be recovered to establish a Dedicated Supply of mice. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services: Tel: 1-800-422-6423 or 1-207-288-5845; Email: jaxservices@jax.org.
This strain is included in the Mouse Mutant Resource collection.
Genomic DNA is available for this strain from the Mouse DNA Resource.

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Control InformationView Control Information in Strain Details.

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The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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Orders & Technical Support
Tel: 800.422.6423 or 207.288.5845
Fax: 207.288.6150
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