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Strain Name:

STOCK a/a MitfMi-wh +/+ Itpr1opt/J

Stock Number:

000302

Availability:

Repository-Cryopreserved

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General Terms and Conditions

Genes & Alleles   Itpr1;   Itpr1opt;   Mitf;   MitfMi-wh;   a;

Product Information

Strain Details

Type JAX® GEMM® Strain - Mutant Stock
Additional information on JAX® GEMM® Strains.
Specieslaboratory mouse
GenerationN1

Strain Description
Mutations at the Mitf locus affect eye size, pigmentation, and the capacity for secondary bone resorption. Mice homozygous for the white allele (MitfMi-wh) display an overall absence of pigment cells with the exception of the retina which expresses a few giving the eye a small amount of pigment. Homozygotes show slight microphthalmia but a normal skeleton. Heterozygotes (MitfMi-wh/+) have a diluted coat color, light ears, a white belly spot, and in rare cases a dorsal spot. In addition, they display abnormalities of both the cochlear and vestibular portions of the inner ear. Mice homozygous for the opisthotonus spontaneous mutation (Itpr1opt) display a characteristic upward arching of head and tail. Homozygous mutant mice can be recognized at about 10 days of age by their loss of balance when standing or moving. Typical behavior of 15 to 20 day old homozygotes consists of falling over and struggling to get up. Agitation and severe opisthotonus ensue with death occuring by weaning age or before.

Related Disease (OMIM) Terms

Albinism, Ocular, with Sensorineural Deafness
Tietz Syndrome
Waardenburg Syndrome, Type IIA; WS2A
Mammalian Phenotype Terms assigned by genotype

The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.

Itpr1opt/Itpr1opt

        involves: C57BLKS
  • lethality-postnatal
  • lethality at weaning (MGI Ref ID J:37547)
    • mice die by weaning age or earlier
    • mice die at 3-4 weeks of age
  • behavior/neurological phenotype
  • abnormal locomotor activity (MGI Ref ID J:37547)
    • abnormal locomotor ability
    • abnormal locomotor coordination (MGI Ref ID J:50383)
      • abnormal walking
  • impaired balance (MGI Ref ID J:13536)
    • at 10 days of age, mice exhibit a loss of balance when standing or moving
    • at 15-20 days of age, mice constantly fall over on their sides
  • impaired coordination (MGI Ref ID J:50383)
  • impaired righting response (MGI Ref ID J:13536)
    • at 15-20 days of age, mice struggle to right themselves
  • opisthotonus (MGI Ref ID J:13536)
    • severe after 15-20 days of age
  • seizures (MGI Ref ID J:50383)
    • visible seizures appear by P14; range from body tremors to full tonic clonic convulsions; progressive with age
    • range from subtle tremors to marked convulsions; progressive severity with age
  • weakness (MGI Ref ID J:50383)
    • weak and sickly appearance by 7 days of age
  • cellular phenotype
  • abnormal cell physiology (MGI Ref ID J:50383)
    • quisqualate (QA) treatment of Purkinje neurons elicited a similar calcium release as controls; repeated QA application showed a less attenuated response in mutant cells than in controls
  • growth/size phenotype
  • decreased body size (MGI Ref ID J:37547)
    • reported as smaller than littermates
  • muscle phenotype
  • opisthotonus (MGI Ref ID J:13536)
    • severe after 15-20 days of age
  • nervous system phenotype
  • *normal* nervous system phenotype (MGI Ref ID J:50383)
    • normal cerebellum morphology; normal numbers and morphology of Purkinje cells
    • gross anatomy of the cerebellum appears normal
    • seizures (MGI Ref ID J:50383)
      • visible seizures appear by P14; range from body tremors to full tonic clonic convulsions; progressive with age
      • range from subtle tremors to marked convulsions; progressive severity with age

MitfMi-wh/Mitf+

        involves: C57BL/6 * DBA
  • pigmentation phenotype
  • abnormal skin pigmentation (MGI Ref ID J:13058)
    • reduced foot pigmentation
    • abnormal tail pigmentation (MGI Ref ID J:13058)
      • reduced tail pigmentation
  • diluted coat color (MGI Ref ID J:13058)
    • coat color is gray and somewhat lighter than that of Myo5ad homozygotes
    • coat color darkens slightly with age
  • reduced eye pigmentation (MGI Ref ID J:13058)
    • eyes are a very dark ruby color
  • skin/coat/nails phenotype
  • abnormal skin pigmentation (MGI Ref ID J:13058)
    • reduced foot pigmentation
    • abnormal tail pigmentation (MGI Ref ID J:13058)
      • reduced tail pigmentation
  • diluted coat color (MGI Ref ID J:13058)
    • coat color is gray and somewhat lighter than that of Myo5ad homozygotes
    • coat color darkens slightly with age
  • limbs/digits/tail phenotype
  • abnormal tail pigmentation (MGI Ref ID J:13058)
    • reduced tail pigmentation
  • vision/eye phenotype
  • reduced eye pigmentation (MGI Ref ID J:13058)
    • eyes are a very dark ruby color

MitfMi-wh/MitfMi-wh

        involves: C57BL/6 * DBA
  • pigmentation phenotype
  • absent coat pigmentation (MGI Ref ID J:13058)
    • coat color is indistinguishable from that of Tyrc homozygotes
  • ocular albinism (MGI Ref ID J:13058)
    • eyes are pink and pigmentless
  • vision/eye phenotype
  • microphthalmia (MGI Ref ID J:13058)
    • eye size appears reduced compared to f Tyrc homozygotes
  • ocular albinism (MGI Ref ID J:13058)
    • eyes are pink and pigmentless
  • growth/size phenotype
  • decreased body size (MGI Ref ID J:13058)
    • reduced body size compared to f Tyrc homozygotes
  • reproductive system phenotype
  • decreased litter size (MGI Ref ID J:13058)
    • litter size is reduced in homozygous female to homozygous male crosses
  • skin/coat/nails phenotype
  • absent coat pigmentation (MGI Ref ID J:13058)
    • coat color is indistinguishable from that of Tyrc homozygotes

MitfMi-wh/MitfMi-wh

        B6.Cg-MitfMi-wh
  • pigmentation phenotype
  • abnormal retinal pigment epithelium morphology (MGI Ref ID J:5046)
    • pigment granules are absent at E11
    • at E11.5 and E12, the pigment layer is irregullar, mainly in the dorsal region
    • after E12 in some area the cells are columnar rather than cuboidal
    • at all stages the number of mitoses is increased compared to control pigment layers
    • abnormal retinal pigmentation (MGI Ref ID J:5046)
      • pigment granules are absent from the pigment layer at E11
      • after E12, a few pigment granules may be found in the front edge of the pigment layer
      • at birth a few pigment granules are present near the iris
  • vision/eye phenotype
  • abnormal eye development (MGI Ref ID J:5046)
    • at E12 the choroid fissure is mostly closed but the joining of the retinal nervous layer is not smooth and a large retinal eversion is present at the rear of the optic cup where the fissure fails to close
    • in newborns the retinal eversion remains obvious in the unclosed portions of the choroid fissure
    • abnormal optic cup morphology (MGI Ref ID J:5046)
      • slightly reduced in size from E13 onwards
      • irregularly formed surrounding less than half of the spherical lens
    • abnormal optic stalk morphology (MGI Ref ID J:5046)
      • slight increase in diameter at E11
      • shorter and somewhat greater in diameter at E11.5 and E12
  • abnormal posterior eye segment morphology (MGI Ref ID J:5046)
    • the lens fills the space normally occupied by the vitreous body
    • abnormal choroid morphology (MGI Ref ID J:5046)
      • at birth the choroid fissure is irregularly closed in the anterior eye and open from the posterior part of the lens to the rear of the optic cup
      • in newborns the retinal eversion remains obvious in the unclosed portions of the choroid fissure
    • abnormal retinal neuronal layer morphology (MGI Ref ID J:5046)
      • at birth, the layers are less clearly defined
    • abnormal retinal pigment epithelium morphology (MGI Ref ID J:5046)
      • pigment granules are absent at E11
      • at E11.5 and E12, the pigment layer is irregullar, mainly in the dorsal region
      • after E12 in some area the cells are columnar rather than cuboidal
      • at all stages the number of mitoses is increased compared to control pigment layers
      • abnormal retinal pigmentation (MGI Ref ID J:5046)
        • pigment granules are absent from the pigment layer at E11
        • after E12, a few pigment granules may be found in the front edge of the pigment layer
        • at birth a few pigment granules are present near the iris
  • microphthalmia (MGI Ref ID J:5046)
    • slightly smaller at birth
  • skeleton phenotype
  • *normal* skeleton phenotype (MGI Ref ID J:5046)
    • unlike MitfMi homozygotes no skeletal abnormalities are seen

Gene & Allele Details

Allele Symbol Itpr1opt
Allele Name opisthotonus
Common Name(s) Itpr-1opt;
Strain of OriginC57BLKS-Leprdb-2J
Gene Symbol and Name Itpr1, inositol 1,4,5-triphosphate receptor 1
Chromosome 6
Gene Common Name(s) D6Pas2; DNA segment, Chr 6, Pasteur Institute 2; I145TR; INSP3R1; IP3R; IP3R1; InsP3R type I; Ip3r; Itpr-1; P400; Pcp-1; Pcp1; Purkinje cell protein 1; SCA15; SCA16; inositol 1,4,5-triphosphate binding protein; opisthotonus; opt;
Molecular Note The molecular defect underlying the phenotype in the opisthotonus mouse involves a genomic deletion that alters the Itpr1 protein. The genomic deletion removes the first two exons from the mRNA, but does not disrupt the translational reading frame. The protein is reduced in expression and is predicted to have lost several modulatory sites. [MGI Ref ID J:37547]
 
Allele Symbol MitfMi-wh
Allele Name white
Common Name(s) Miwh;
Strain of Origin(C57BL x DBA)F1
Gene Symbol and Name Mitf, microphthalmia-associated transcription factor
Chromosome 6
Gene Common Name(s) MI; WS2A; bHLHe32; black eyed white; bw; mi; microphthalmia; vit; vitiligo; wh;
General Note Combination heterozygotes of MitfMi-wh/MitfMi, MitfMi-wh/MitfMi-b, and MitfMi-wh/MitfMi-ws show some interallelic complementation in that the heterozygote of the two alleles is more nearlynormal than either homozygote (J:12967, J:19656). MitfMi-b/MitfMi-wh agouti mice are light cream with white spots and ruby eyes (J:15061).
Molecular Note T to A transversion at bp 764, which leads to an isoleucine to asparagine substitution at the corresponding amino acid (212) in the encoded protein. This mutation is in the basic region of the protein. [MGI Ref ID J:19656] [MGI Ref ID J:21366]
 
Allele Symbol a
Allele Name nonagouti

Control Information

  Allele   Control
 Itpr1opt  Untyped from the colony
   Untyped from the colony
 
  Considerations for Choosing Controls

Genotyping Protocols

Itpr1opt

Related Strains

Strains carrying   Itpr1opt allele
000019   B6C3Fe-a/a-Itpr1opt/J
View Strains carrying   Itpr1opt     (1 strain)

View Strains carrying   MitfMi-wh     (7 strains)

Strains carrying   a allele
003879   B10;TFLe-a/a T tf/+ tf/J
001538   B6 x B6C3Sn a/A-T(1;9)27H/J
000916   B6 x B6C3Sn a/A-T(5;12)31H/J
000602   B6 x B6C3Sn a/A-T(8;16)17H/J
000618   B6 x FSB/GnEi a/a Ctslfs/J
000577   B6 x STOCK a Oca2p Hps5ru2 Ednrbs/J
000601   B6 x STOCK a/a T(7;18)50H/J
000592   B6 x STOCK T(2;4)13H a/J
000001   B6.C3 A/a Mgrn1md/J
000785   B6;D2-a Es1e/J
000604   B6C3 a/A-T(10;13)199H +/+ Lystbg-J/J or Lystbg-2J/J
002807   B6C3Fe a/a-Meox2fla/J
000224   B6C3Fe a/a-Scyl1mdf/J
001037   B6C3Fe a/a-Agtpbp1pcd/J
000221   B6C3Fe a/a-Alx4lst-J/J
002062   B6C3Fe a/a-Atp7aMo-8J/J
001756   B6C3Fe a/a-Cacng2stg/J
001815   B6C3Fe a/a-Col1a2oim/J
000231   B6C3Fe a/a-Csf1op/J
000209   B6C3Fe a/a-Dh/J
000211   B6C3Fe a/a-Dstdt-J/J
000210   B6C3Fe a/a-Edardl-J/J
000207   B6C3Fe a/a-Edaraddcr/J
000182   B6C3Fe a/a-Eef1a2wst/J
001278   B6C3Fe a/a-Glra1spd/J
000241   B6C3Fe a/a-Glrbspa/J
002875   B6C3Fe a/a-Hoxd13spdh/J
000304   B6C3Fe a/a-Krt71Ca Scn8amed-J/J
000226   B6C3Fe a/a-Largemyd/J
000636   B6C3Fe a/a-Lmx1adr-J/J
001280   B6C3Fe a/a-Lse/J
001573   B6C3Fe a/a-MitfMi/J
001035   B6C3Fe a/a-Napahyh/J
000181   B6C3Fe a/a-Otogtwt/J
000278   B6C3Fe a/a-Papss2bm Hps1ep Hps6ru/J
000205   B6C3Fe a/a-Papss2bm/J
002078   B6C3Fe a/a-Pcdh15av-2J/J
000246   B6C3Fe a/a-Pitpnavb/J
001430   B6C3Fe a/a-Ptch1mes/J
000506   B6C3Fe a/a-Qkqk/J
000235   B6C3Fe a/a-Relnrl/J
000237   B6C3Fe a/a-Rorasg/J
000290   B6C3Fe a/a-Sox10Dom/J
000230   B6C3Fe a/a-Tcirg1oc/J
003612   B6C3Fe a/a-Trak1hyrt/J
001512   B6C3Fe a/a-Ttnmdm/J
001607   B6C3Fe a/a-Unc5crcm/J
000005   B6C3Fe a/a-Wc/J
000243   B6C3Fe a/a-Wnt1sw/J
000248   B6C3Fe a/a-Xpl/J
001750   B6C3Fe a/a-XsJ/J
000624   B6C3Fe a/a-anx/J
003020   B6C3Fe a/a-dep/J
002018   B6C3Fe a/a-din/J
002339   B6C3Fe a/a-nma/J
000240   B6C3Fe a/a-soc/J
000063   B6C3Fe a/a-sy/J
001055   B6C3Fe a/a-tip/J
000245   B6C3Fe a/a-tn/J
000296   B6C3Fe-a/a Hoxa13Hd Mcoln3Va-J/J
000019   B6C3Fe-a/a-Itpr1opt/J
001022   B6C3FeF1/J a/a
000971   B6EiC3 a/A-Och/J
000551   B6EiC3 a/A-Tbx15de-H/J
006450   B6EiC3 a/A-Vss/J
000557   B6EiC3-+ a/LnpUl A/J
000503   B6EiC3Sn a/A-Gy/J
001811   B6EiC3Sn a/A-Otcspf-ash/J
002343   B6EiC3Sn a/A-Otcspf/J
000391   B6EiC3Sn a/A-Pax6Sey-Dey/J
001924   B6EiC3Sn a/A-Ts(1716)65Dn
001923   B6EiC3Sn a/A-Ts(417)2Lws Tim/J
000225   C3FeLe.B6 a/a-Ptpn6me/J
000198   C3FeLe.B6-a/J
000291   C3FeLe.Cg-a/a Hm KitlSl Krt71Ca-J/J
001886   C3HeB/FeJLe a/a-gnd/J
000584   C57BL/6J-+ T(1;2)5Ca/a +/J
000284   CWD/LeJ
000670   DBA/1J
000671   DBA/2J
001057   HPT/LeJ
000260   JGBF/LeJ
000265   MY/HuLeJ
000308   SSL/LeJ
000994   STOCK a Myo5ad Mregdsu/J
000064   STOCK a Tyrp1b Sisi/J
002238   STOCK a Tyrp1b shmy/J
001433   STOCK a skt/J
000579   STOCK a tp/J
000319   STOCK a us/J
002648   STOCK a/a Cln6nclf/J
000317   STOCK a/a Egfrwa2/J
000286   STOCK a/a Myo5ad fd/+ +/J
000206   STOCK a/a Tyrc-h/J
001432   STOCK a/a Tyrp1b sks/Tyrp1b +/J
000281   STOCK a/a ma ft/ma ft/J
000312   STOCK stb + a/+ Fignfi a/J
000596   STOCK T(2;11)30H/+ x AEJ-a Gdf5bp-H/J or A/J-a Gdf5bp-J/J
000970   STOCK T(2;16)28H A/T(2;16)28H a/J
000590   STOCK T(2;4)1Sn a/J
000594   STOCK T(2;8)26H a/T(2;8)26H a Tyrp1+/Tyrp1b/J
000623   TR/DiEiJ
View Strains carrying   a     (102 strains)

Strains carrying other alleles of Mitf
003046   B6(FVB)-MitfMi-Mee/J
000158   B6.Cg-MitfMi-wh/MitfMi/J
000184   B6.Cg-MitfMi-wh/Mitfmi-rw/J
000157   B6.Cg-MitfMi-wh/Mitfmi-sp/J
001573   B6C3Fe a/a-MitfMi/J
000956   B6CB-Mitfmi-rw/J
002611   C57BL/6J-Mitfmi-bws/J
002134   C57BL/6J-Mitfmi-vit/J
View Strains carrying other alleles of Mitf     (8 strains)

Strains carrying other alleles of a
003301   (C57BL/6J x C3H-Eya1bor)F1/J
000251   AEJ.Cg-ae +/a Gdf5bp-H/J
000202   AEJ/Gn-bd/J
000199   AEJ/GnLeJ
000427   B10.CE-H13b Aw/(30NX)SnJ
000420   B10.LP-H13b Aw/Sn
000477   B10.PA-Pldnpa H3e at/SnJ
000419   B10.UW-H3b we Pax1un at/SnJ
000593   B6 x B6CBCa Aw-J/A-Grid2Lc T(2;6)7Ca MitfMi-wh/J
000502   B6 x B6CBCa Aw-J/A-Myo5aflr Gnb5flr/J
000599   B6 x B6CBCa Aw-J/A-T(5;13)264Ca KitW-v/J
002083   B6 x B6EiC3 a/A-T(7;16)235Dn/J
000507   B6 x B6EiC3 a/A-Otcspf/J
002016   B6(Cg)-Aw-J EdaTa-6J Chr YB6-Sxr/EiJ
000552   B6-Aw-J-EdaTa-6J.Cg-Sxr
001730   B6-Aw-J-EdaTa-6J.Cg-Sxrb Hya-/J
000841   B6-Aw-J.CBy-EdaTa-By/J
001809   B6-Aw-J.Cg-EdaTa-6J +/+ ArTfm/J
000600   B6-Gpi1b x B6CBCa Aw-J/A-T(7;15)9H Gpi1a/J
000769   B6.C/(HZ18)By-at-44J/J
000203   B6.C3-Aiy/a/J
000017   B6.C3Fe-Avy/J
000628   B6.CE-A Amy1b Amy2b/J
005505   B6.Cg-Ay Slc7a11sut/LmLlp
000021   B6.Cg-Ay/J
001572   B6.Cg-am-J/J
100409   B6129PF1/J-Aw-J/Aw
004200   B6;CBACa Aw-J/A-Npr2cn-2J/J
000505   B6C3 Aw-J/A-Mutedmu/J
000604   B6C3 a/A-T(10;13)199H +/+ Lystbg-J/J or Lystbg-2J/J
000065   B6C3Fe a/a-we Pax1un at/J
000314   B6CBACa Aw-J/A-EdaTa/J-XO
000501   B6CBACa Aw-J/A-Aifm1Hq/J
001046   B6CBACa Aw-J/A-Grid2Lc/J
000500   B6CBACa Aw-J/A-Gs/J
002703   B6CBACa Aw-J/A-Hydinhy3/J
000247   B6CBACa Aw-J/A-Kcnj6wv/J
000287   B6CBACa Aw-J/A-Plp1jp EdaTa/J
000515   B6CBACa Aw-J/A-SfnEr/J
000242   B6CBACa Aw-J/A-spc/J
000288   B6CBACa Aw-J/A-we a Mafbkr/J
001201   B6CBACaF1/J-Aw-J/A
001752   B6CBCa Aw-J/A-T(7;15)9H/J
006450   B6EiC3 a/A-Vss/J
000557   B6EiC3-+ a/LnpUl A/J
000504   B6EiC3Sn a/A-Cacnb4lh/J
000553   B6EiC3Sn a/A-Egfrwa2 Wnt3avt/J
001811   B6EiC3Sn a/A-Otcspf-ash/J
002343   B6EiC3Sn a/A-Otcspf/J
001923   B6EiC3Sn a/A-Ts(417)2Lws Tim/J
000200   C3FeB6 A/Aw-J-Ankank/J
000638   C3FeB6 A/Aw-J-Spnb4qv-J/J
001203   C3FeB6F1/J A/Aw-J
001272   C3H/HeSnJ-Ahvy/J
000099   C3HeB/FeJ-Avy/J
000338   C57BL/6J Aw-J-EdaTa-6J/J
000258   C57BL/6J-Ai/a/J
000774   C57BL/6J-Asy/a/J
000569   C57BL/6J-Aw-J-EdaTa +/+ ArTfm/J
000051   C57BL/6J-Aw-J/J
000055   C57BL/6J-at-33J/J
000070   C57BL/6J-atd/J
002468   KK.Cg-Ay/J
000262   LS/LeJ
000283   LT.CAST-A/J
001759   STOCK A Tyrc Sha/J
001427   STOCK Aw us/J
View Strains carrying other alleles of a     (67 strains)

Research Applications

This mouse can be used to support research in many areas including:

Itpr1opt related

Neurobiology Research
Epilepsy
Metabolic Defects
Receptor Defects

MitfMi-wh related

Dermatology Research
Color and White Spotting Defects

Endocrine Deficiency Research
Bone/Bone Marrow Defects

Immunology and Inflammation Research
Immunodeficiency Associated with Other Defects

Mouse/Human Gene Homologs
Waardenburg syndrome, type IIA

Neurobiology Research
Vestibular and Hearing Defects

Sensorineural Research
Eye Defects
Vestibular and Hearing Defects

References

Additional References

Price and Supply Information

Strain Name: STOCK a/a MitfMi-wh +/+ Itpr1opt/J
Stock Number: 000302

Price Details

IMPORTANT NOTE: Prices are based on shipping destination. To view prices, select your shipping destination.

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Supply Details

Standard SupplyRepository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information.
Supply Notes Cryorecovery of Strains Needing Progeny Testing.
The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two untested males and two untested females (two pairs) will be recovered, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the overall recovery time to approximately 25 weeks. However, all pups recovered will be sent.

Progeny testing is required to identify the genotype of mice of this strain, as a genotyping assay is not available. This type of testing involves breeding the recovered animals and assessing the phenotype of the offspring in order to identify animals carrying the mutation of interest. We can perform the progeny testing for you as a service or we can ship all recovered animals (at least two untested pairs) to you for progeny testing at your facility. If you perform the progeny testing, there is NO guarantee that a carrier will be identified. If we perform progeny testing as a service, additional breeding time will be required. In this case, when a male and female (one pair) are identified that carry the mutation, they and their offspring will be shipped. Delivery time for strains requiring progeny testing often exceeds 25 weeks and may take 12 months or more due to the difficulties in breeding some strains. The progeny testing cost is in addition to the recovery cost and is based on the number of boxes used and the time taken to produce the mice identified as carrying the mutation. Please note that identified pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Please contact Customer Service for more information on the cost of progeny testing for a strain: Tel: 1-800-422-6423 or 1-207-288-5845.

Cryorecovery to establish a Dedicated Supply for greater quantities of mice
One to two pairs will be recovered to establish a Dedicated Supply of mice. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services: Tel: 1-800-422-6423 or 1-207-288-5845; Email: jaxservices@jax.org.
Genomic DNA is available for this strain from the Mouse DNA Resource.

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Control InformationView Control Information in Strain Details.

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The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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