Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Former Names STOCK Dll3pu + Tyrc-ch/+ p Tyrc-ch/J    (Changed: 11-FEB-08 ) Type Mutant Stock; Radiation Induced Mutation; Spontaneous Mutation; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Mating System Progeny Tested         (Female x Male)   13-FEB-08 TJL Breeding Scheme: progeny test; for Dll3pu: heterozygote x heterozygote in repulsion with Oca2p; for Oca2p: heterozygote x heterozygote in repulsion with Dll3pu; for Tyrc-ch: homozygote x homozygote TJL Breeding Summary: this strain is maintained with Dll3pu and Oca2p in repulsion via a progeny test in which ? + Tyrc-ch/+ ? Tyrc-ch are progeny tested then bred Dll3pu+Tyrc-ch/+ Oca2pTyrc-ch x Dll3pu+Tyrc-ch/+ Oca2pTyrc-ch. Species laboratory mouse Generation F14 Generation Definitions

Appearance
pink-eyed fawn, pudgy
Related Genotype: Dll3^pu Oca2^p Tyr^c-ch/Dll3^pu Oca2^p Tyr^c-ch

pink-eyed fawn, unaffected
Related Genotype: + Oca2^p Tyr^c-ch/? Oca2^p Tyr^c-ch

chinchilla, unaffected
Related Genotype: ? + Tyr^c-ch/+ ? Tyr^c-ch

chinchilla, pudgy
Related Genotype: Dll3^pu ? Tyr^c-ch/Dll3^pu + Tyr^c-ch

Important Note
This strain is homozygous for Tyr^c-ch and segregating for Dll3^pu and Oca2^p which are maintained in repulsion.

Development
Pudgy (Dll3^pu) arose in the descendants of an x-rayed (101/Rl x C3H/Rl)F1 male from the specific locus experiments at Oak Ridge National Laboratory prior to 1961. It is located on Chromosome 7 linked to pink eyed dilution (Oca2^p) and chinchilla (Tyr^c-ch). The pudgy stock with Oca2^p and Tyr^c-ch was imported into The Jackson Laboratory from Dr. L.B. Russell at Oak Ridge in 1961. It was maintained as a close (not inbred) stock by mating Dll3^pu + Tyr^c-ch/Dll3^pu + Tyr^c-ch males to + Oca2^p Tyr^c-ch/+ Oca2^p Tyr^c-ch females in one generation followed by Dll3^pu + Tyr^c-ch/+ Oca2^p Tyr^c-ch matings the next generation until 1983 and then it was sibling mated using the same alternating generations. It was cryopreserved in 1983 using Dll3^pu + Tyr^c-ch/+ Oca2^p Tyr^c-ch males x Dll3^pu + Tyr^c-ch/+ Oca2^p Tyr^c-ch or untested females at F13.

Control Information

	Control
	Untyped from the colony
Considerations for Choosing Controls

Related Strains

Strains carrying   Oca2^p allele

000004	ABP/LeJ
000577	B6 x STOCK a Oca2p Hps5ru2 Ednrbs/J
001059	B6By.Cg-Oca2p/J
000619	FS/EiJ
001618	STOCK Oca2p Prop1df/J

View Strains carrying   Oca2^p     (5 strains)

Strains carrying   Tyr^c-ch allele

000091	129T1/Sv-Oca2+ Tyrc-ch Dnd1Ter/J
000578	B6 x STOCK Tyrc-ch Bmp5se +/+ Myo6sv/J
000619	FS/EiJ
004624	FVB.129P2-Pde6b+ Tyrc-ch Fmr1tm1Cgr/J
004828	FVB.129P2-Pde6b+ Tyrc-ch/AntJ
000271	SH1/LeJ

View Strains carrying   Tyr^c-ch     (6 strains)

Strains carrying other alleles of Dll3

005040

STOCK Tg(Pfkl)224Yg/J-Dll3pu-J/GrsrJ

View Strains carrying other alleles of Dll3     (1 strain)

Strains carrying other alleles of Oca2

000090	129S1/Sv-Oca2+ Tyr+ KitlSl-J/J
001279	129T1/Sv-Oca2+ Tyrc-ch Aft/J
000091	129T1/Sv-Oca2+ Tyrc-ch Dnd1Ter/J
000004	ABP/LeJ
000822	B6 x 129S1/SvEi Oca2+ Tyr+-Vsx2or-J/J
000577	B6 x STOCK a Oca2p Hps5ru2 Ednrbs/J
001059	B6By.Cg-Oca2p/J
002460	C3H/HeJ-Oca2p-J Is(7;1)40H/J
000513	C3H/HeJ-Oca2p-J/J
001136	C57BL/6J-Oca2p-un+2J/J
001506	C57BL/6J-Oca2p-un+3J/J
001810	C57BL/6J-Oca2p-un+4J/J
001513	C57BL/6J-Oca2p-un+5J/J
001499	C57BL/6J-Oca2p-un+6J/J
001033	C57BL/6J-Oca2p-un+J/J
000028	C57BL/6J-Oca2p-un/J
000619	FS/EiJ
000494	J.Cg-Oca2+ Tyr+ Lystbg/J
001584	STOCK Oca2p-J/Oca2p-bs/J
001585	STOCK Oca2p-d/Oca2p-25H/J
000823	STOCK Oca2p-d/Oca2p-6H/J
001747	STOCK Oca2p-d/Oca2p-cp/J
001618	STOCK Oca2p Prop1df/J

View Strains carrying other alleles of Oca2     (23 strains)

Strains carrying other alleles of Tyr

000090	129S1/Sv-Oca2+ Tyr+ KitlSl-J/J
000091	129T1/Sv-Oca2+ Tyrc-ch Dnd1Ter/J
005445	A.B6 Tyr+-Cybanmf333/J
005012	A.B6 Tyr+-Myo5ad-l31J/J
002565	A.B6-Tyr+/J
001017	AKXD10/TyJ
000765	AKXD13/TyJ
000954	AKXD15/TyJ
000958	AKXD16/TyJ
001093	AKXD18/TyJ
001062	AKXD21/TyJ
000947	AKXD22/TyJ
000969	AKXD24/TyJ
000777	AKXD6/TyJ
000763	AKXD9/TyJ
000409	B10.129P-H1b Hbbd Tyrc Ea7a/(5M)oSnJ
000418	B10.129P-H1b Tyrc Hbbd/(5M)nSnJ
000432	B10.C-H1b Hbbd Tyrc/(41N)SnJ
000580	B10.D2/nSn-Tyrc-4J/J
000822	B6 x 129S1/SvEi Oca2+ Tyr+-Vsx2or-J/J
000578	B6 x STOCK Tyrc-ch Bmp5se +/+ Myo6sv/J
017614	B6(Cg)-Tyrc-2J Tg(UBC-mCherry)1Phbs/J
000058	B6(Cg)-Tyrc-2J/J
008647	B6.129P2(Cg)-Trpa1tm1Kykw Tyrc-2J/J
000383	B6.C-Tyrc H1b Hbbd/ByJ
013590	B6.Cg-Braftm1Mmcm Ptentm1Hwu Tg(Tyr-cre/ERT2)13Bos/BosJ
003819	B6.Cg-Per2tm1Brd Tyrc-Brd/J
007484	B6.Cg-Tyrc-2J Tg(Tyr)3412ARpw Tg(Sry-EGFP)92Ei/EiJ
000035	B6.Cg-Tyrc-J/J
000104	B6.Cg-Tyrc-h/J
012328	B6.Cg-Tg(Tyr-cre/ERT2)13Bos/J
000054	B6.D2-Tyrc-p/J
000899	C.B6-Tyr+ Hbbs/J
000339	C3H/HeJ-Tyrc-9J/J
001294	C3H/HeJ-Tyrc-a/J
001002	C57BL/10SnJ-Tyrc-11J/J
001006	CBA/J-Tyrc-10J/J
000657	CE/J
000619	FS/EiJ
004624	FVB.129P2-Pde6b+ Tyrc-ch Fmr1tm1Cgr/J
004828	FVB.129P2-Pde6b+ Tyrc-ch/AntJ
007483	FVB.Cg-Tg(Tyr)3412ARpw Tg(Sry-EGFP)92Ei/EiJ
000494	J.Cg-Oca2+ Tyr+ Lystbg/J
002281	NFS.C58-Tyr+/J
004304	NOD.CBALs-Tyr+/LtJ
000271	SH1/LeJ
001759	STOCK A Tyrc Sha/J
000006	STOCK Hk Tyrc/J
014173	STOCK Tyrc-2J Omptm1.1(COP4*/EYFP)Tboz/J
000206	STOCK a/a Tyrc-h/J

View Strains carrying other alleles of Tyr     (50 strains)

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI

      assigned by genotype

The following phenotype information may relate to a genetic background differing from this JAX^® Mice strain.

Dll3^pu/Dll3^pu

        involves: 101/Rl * C3H/Rl

• mortality/aging
• partial postnatal lethality
  • reduced viability after birth   (MGI Ref ID J:14975)
• growth/size phenotype
• decreased body length
  • the whole trunk region is shortened   (MGI Ref ID J:14975)
• embryogenesis phenotype
• abnormal somite development
  • homozygotes exhibit defective segmentation; although the paraxial mesoderm forms somite tissue with an epithelially arranged outer layer, this material either shows only an abortive segmentation into somites or, in the tail, none at all   (MGI Ref ID J:14975)
  • somites are not clearly defined along the tail, are irregular in shape, and the intersegmental fissures are less well defined   (MGI Ref ID J:14975)
  • presomitic mesoderm is thickened and disorganized at E9.5 and segmental borders between epithelial somites are not formed   (MGI Ref ID J:48518)
• • abnormal rostral-caudal patterning of the somites
    • the boundaries between rostral-caudal compartments within somites are severely disrupted as indicated by abnormal spatial localization of various gene markers   (MGI Ref ID J:48518)
  • abnormal somite shape   (MGI Ref ID J:14975)
    • somites appear irregular in shape   (MGI Ref ID J:48518)
  • abnormal somite size
    • somites appear irregular in size   (MGI Ref ID J:48518)
  • delayed somite formation
    • in the tail, the paraxial mesoderm is formed into solid somite tissue with some delay and in a less orderly fashion   (MGI Ref ID J:14975)
• skeleton phenotype
• abnormal cranium morphology
  • anomalies in the skull in the immediate vicinity of the foramen magnum   (MGI Ref ID J:14975)
• abnormal rib morphology
  • ribs are irregular, particularly in the caudal half of the thoracic region, where the ribs tend to be bunched together   (MGI Ref ID J:14975)
• • rib bifurcation   (MGI Ref ID J:48518)
  • rib fusion   (MGI Ref ID J:48518)
    • irregular rib fusions   (MGI Ref ID J:14975)
• abnormal sclerotome morphology
  • sclerotome tissue remains continuous and gives rise to abnormal blastema which then chondrify and ossify   (MGI Ref ID J:14975)
• abnormal sternebra morphology
  • fusions between adjacent sternebrae, often at an angle, are common   (MGI Ref ID J:14975)
• abnormal vertebrae morphology
  • vertebral column consists of a jumble of vertebrae and fragments of vertebrae   (MGI Ref ID J:14975)
  • deformed vertebrae   (MGI Ref ID J:48518)
• • decreased caudal vertebrae number   (MGI Ref ID J:14975)
  • vertebral fusion
    • highly irregular fusions between vertebrae and fragments of vertebrae   (MGI Ref ID J:14975)
• kyphosis   (MGI Ref ID J:14975)
• lordosis   (MGI Ref ID J:14975)
• short vertebral column
  • shortened all along its length   (MGI Ref ID J:14975)
• muscle phenotype
• abnormal dermomyotome development
  • segmentation into the dermomyotome is belated   (MGI Ref ID J:14975)
• nervous system phenotype
• abnormal brain ependyma morphology
  • 3 of 6 adults show unusual unilateral and bilateral cysts in the lateral ventricular ependymal linings   (MGI Ref ID J:48518)
• abnormal dorsal root ganglion morphology
  • spinal ganglia are irregularly formed and unevenly spaced   (MGI Ref ID J:48518)
• • fused dorsal root ganglion
    • spinal ganglia is an almost continuous mass instead of being separate from each other as in wild-type   (MGI Ref ID J:14975)
• abnormal spinal nerve morphology
  • spinal nerves are irregularly formed and unevenly spaced   (MGI Ref ID J:48518)
• limbs/digits/tail phenotype
• decreased caudal vertebrae number   (MGI Ref ID J:14975)
• short tail
  • tail is reduced to a small stub or is all but absent   (MGI Ref ID J:14975)
• thin tail
  • tails are thinner distally and are pointed at the tip at E14   (MGI Ref ID J:14975)
• behavior/neurological phenotype
• abnormal sexual interaction
  • mutants are poor breeders   (MGI Ref ID J:14975)
• craniofacial phenotype
• abnormal cranium morphology
  • anomalies in the skull in the immediate vicinity of the foramen magnum   (MGI Ref ID J:14975)

Dll3^pu/Dll3^pu

        involves: 101/Rl * C3H/He * C3H/Rl * C57BL/6

• growth/size phenotype
• decreased body length
  • truncation of the body   (MGI Ref ID J:75954)
• limbs/digits/tail phenotype
• short tail
  • tail is short, however it is longer than in Dll3^tm1Rbe homozygous embryos   (MGI Ref ID J:75954)
• skeleton phenotype
• abnormal skeleton morphology
  • at E14.5, defects in the preskeleton are very similar to those of Dll3^tm1Rbe homozygous embryos   (MGI Ref ID J:75954)
  • skeletal dysplasia of embryos is less severe than seen in Dll3^tm1Rbe homozygous embryos   (MGI Ref ID J:75954)
• • abnormal vertebrae morphology
    • misaligned vertebrae   (MGI Ref ID J:75954)
  • rib fusion   (MGI Ref ID J:75954)

View Research Applications

Research Applications

This mouse can be used to support research in many areas including:

Dll3^pu related

Developmental Biology Research
Neurodevelopmental Defects
Skeletal Defects

Oca2^p related

Dermatology Research
Color and White Spotting Defects

Mouse/Human Gene Homologs
albinism, oculocutaneous type II, OCA2

Neurobiology Research
Angelman syndrome

Tyr^c-ch related

Dermatology Research
Color and White Spotting Defects

Developmental Biology Research
Neurodevelopmental Defects
Skeletal Defects

Mouse/Human Gene Homologs
albinism, tyrosine negative

Genes & Alleles

Gene & Allele Information provided by MGI

Allele Symbol		Dll3pu
Allele Name		pudgy
Allele Type		Radiation induced
Common Name(s)		pu;
Strain of Origin		(101/Rl x C3H/Rl)F1
Gene Symbol and Name		Dll3, delta-like 3 (Drosophila)
Chromosome		7
Gene Common Name(s)		SCDO1; pu; pudgy;
General Note		The pudgy mutation appeared in descendants of an X-rayed male at the Oak Ridge National Laboratory. (J:14975). It has been suggested that Dll3pu may be a recurrence of stub (sb), a skeletal mutant now extinct (J:245).
Molecular Note		Sequencing of Dll3 shows that Dll3pu mutants have a 4 bp deletion in the third exon leading to a frameshift and early truncation of the expected Dll3 product ahead of the conserved DSL domain. [MGI Ref ID J:48518]
Allele Symbol		Oca2p
Allele Name		pink-eyed dilution
Allele Type		Spontaneous
Common Name(s)		p;
Strain of Origin		Asiatic fancy mice
Gene Symbol and Name		Oca2, oculocutaneous albinism II
Chromosome		7
Gene Common Name(s)		BEY; BEY1; BEY2; BOCA; D15S12; D7H15S12; D7Icr28RN; D7Nic1; DNA segment, Chr 7, Institute for Cancer Research 28RN; DNA segment, Chr 7, Nicholls 1; DNA segment, Chr 7, human D15S12; EYCL; EYCL2; EYCL3; HCL3; P; PED; SHEP1; p; pink-eyed dilution;
General Note		p is a very old mutation carried in many varieties of fancy mice (J:12958). It has been suggested that the original mutation occurred in Japanese wild mice, Mus musculus molossinus (J:19782). Homozygotes have pink eyes with pigmentation very much reduced but not completely absent in both the retina and choroid. The black pigment of the hair is very much diluted, but the yellow pigment is only slightly affected. Pigment granules are irregular and shred-like in shape. The small amount of pigment they contain is of wild-type color (J:12970, J:12958). The fine structure of the pigment granules was said by Moyer (J:5001) to be disrupted, but Hearing et al. (J:5346) found the structure to be normal, with premature termination of the melanization process. In tissue culture of the eye, the amount of pigment formed can be increased by increasing the concentration of tyrosine. This suggests that p may block the melanin-synthesizing pathway by interference with tyrosine supply (J:12726). The site of gene action is in the melanocytes and not in either the dermis or the epidermis (J:7988). A presumed p gene has been cloned (J:2206). It was isolated from mouse melanoma and melanocyte libraries and is missing or altered in six independent p mutant alleles (J:2206). By sequence comparison, the human P locus, deletions of which are associated with hypopigmentation, is orthologous to p (J:2206). P maps to Chr 15q, near the Prader--Willi syndrome locus. On the basis of this location, the p mutation has been proposed to provide a mouse model for Prader--Willi syndrome, for Angelman syndrome, for one form of hypomelanosis of Ito (J:3253), and for type II oculocutaneous albinism (J:3600). A small nuclear ribonucleoprotein particle gene Snrpn maps near p and its human ortholog in the homologous Prader--Willi region of human Chromosome 15 (J:3623). Snrpn appears to be a better candidate for the Prader-Willi syndrome ortholog. P is deleted in human type II oculocutaneous albinism, making p a model for this disease (J:3600).
Allele Symbol		Tyrc-ch
Allele Name		chinchilla
Allele Type		Spontaneous
Common Name(s)		cch; cr;
Strain of Origin		fancier's stock
Gene Symbol and Name		Tyr, tyrosinase
Chromosome		7
Gene Common Name(s)		C; CMM8; OCA1A; OCAIA; SHEP3; albino; c; skc35; skin/coat color 35;
Molecular Note		The mutation in the chinchilla allele was found to be a G to A point mutation that results in an amino acid change at position 464 from alanine to threonine. [MGI Ref ID J:19279]

Genotyping

Genotyping Information

Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Additional References

Gridley T. 2003. Notch signaling and inherited disease syndromes. Hum Mol Genet 12(Suppl 1):R9-R13. [PubMed: 12668592]  [MGI Ref ID J:82719]

Dll3^pu related

Chen J; Kang L; Zhang N. 2005. Negative feedback loop formed by Lunatic fringe and Hes7 controls their oscillatory expression during somitogenesis. Genesis 43(4):196-204. [PubMed: 16342160]  [MGI Ref ID J:104451]

Dunn LC; Gluecksohn-Schoenheimer S. 1942. Stub, a new mutation in the mouse with marked effects on the spinal column J Hered 33:235-9.  [MGI Ref ID J:245]

Dunwoodie SL; Clements M; Sparrow DB; Sa X; Conlon RA; Beddington RS. 2002. Axial skeletal defects caused by mutation in the spondylocostal dysplasia/pudgy gene Dll3 are associated with disruption of the segmentation clock within the presomitic mesoderm. Development 129(7):1795-806. [PubMed: 11923214]  [MGI Ref ID J:75954]

Gruneberg H. 1961. Genetical studies on the skeleton of the mouse. XXIX. Pudgy Genet Res 2:384-93.  [MGI Ref ID J:14975]

Hartman BH; Hayashi T; Nelson BR; Bermingham-McDonogh O; Reh TA. 2007. Dll3 is expressed in developing hair cells in the mammalian cochlea. Dev Dyn 236(10):2875-83. [PubMed: 17823936]  [MGI Ref ID J:125514]

Kusumi K; Dunwoodie SL; Krumlauf R. 2001. Dynamic expression patterns of the pudgy/spondylocostal dysostosis gene Dll3 in the developing nervous system. Mech Dev 100(1):141-4. [PubMed: 11118901]  [MGI Ref ID J:88448]

Kusumi K; Mimoto MS; Covello KL; Beddington RS; Krumlauf R; Dunwoodie SL. 2004. Dll3 pudgy mutation differentially disrupts dynamic expression of somite genes. Genesis 39(2):115-21. [PubMed: 15170697]  [MGI Ref ID J:107136]

Kusumi K; Sun ES; Kerrebrock AW; Bronson RT; Chi DC; Bulotsky MS ; Spencer JB ; Birren BW ; Frankel WN ; Lander ES. 1998. The mouse pudgy mutation disrupts Delta homologue Dll3 and initiation of early somite boundaries. Nat Genet 19(3):274-8. [PubMed: 9662403]  [MGI Ref ID J:48518]

Machka C; Kersten M; Zobawa M; Harder A; Horsch M; Halder T; Lottspeich F; Hrabe de Angelis M; Beckers J. 2005. Identification of Dll1 (Delta1) target genes during mouse embryogenesis using differential expression profiling. Gene Expr Patterns 6(1):94-101. [PubMed: 15979417]  [MGI Ref ID J:103128]

Nelson BR; Hartman BH; Ray CA; Hayashi T; Bermingham-McDonogh O; Reh TA. 2009. Acheate-scute like 1 (Ascl1) is required for normal delta-like (Dll) gene expression and notch signaling during retinal development. Dev Dyn 238(9):2163-2178. [PubMed: 19191219]  [MGI Ref ID J:151457]

Schubert FR; Tremblay P; Mansouri A; Faisst AM; Kammandel B; Lumsden A; Gruss P; Dietrich S. 2001. Early mesodermal phenotypes in splotch suggest a role for Pax3 in the formation of epithelial somites. Dev Dyn 222(3):506-21. [PubMed: 11747084]  [MGI Ref ID J:72525]

Schwarting GA; Gridley T; Henion TR. 2007. Notch1 expression and ligand interactions in progenitor cells of the mouse olfactory epithelium. J Mol Histol 38(6):543-53. [PubMed: 17605079]  [MGI Ref ID J:130594]

William DA; Saitta B; Gibson JD; Traas J; Markov V; Gonzalez DM; Sewell W; Anderson DM; Pratt SC; Rappaport EF; Kusumi K. 2007. Identification of oscillatory genes in somitogenesis from functional genomic analysis of a human mesenchymal stem cell model. Dev Biol 305(1):172-86. [PubMed: 17362910]  [MGI Ref ID J:121317]

Oca2^p related

Brilliant MH; Ching A; Nakatsu Y; Eicher EM. 1994. The original pink-eyed dilution mutation (p) arose in Asiatic mice: implications for the H4 minor histocompatibility antigen, Myod1 regulation and the origin of inbred strains. Genetics 138(1):203-11. [PubMed: 8001787]  [MGI Ref ID J:19782]

Cattanach BM. 1961. A chemically-induced variegated-type position effect in the mouse. Z Vererbungsl 92:165-82. [PubMed: 13877379]  [MGI Ref ID J:160128]

Cook MN; Dunning JP; Wiley RG; Chesler EJ; Johnson DK; Miller DR; Goldowitz D. 2007. Neurobehavioral mutants identified in an ENU-mutagenesis project. Mamm Genome 18(8):559-72. [PubMed: 17629744]  [MGI Ref ID J:125716]

Feldman HW. 1924. Linkage of Albino Allelomorphs in Rats and Mice. Genetics 9(5):487-92. [PubMed: 17246054]  [MGI Ref ID J:93]

Gardner JM; Nakatsu Y; Gondo Y; Lee S; Lyon MF; King RA; Brilliant MH. 1992. The mouse pink-eyed dilution gene: association with human Prader-Willi and Angelman syndromes. Science 257(5073):1121-4. [PubMed: 1509264]  [MGI Ref ID J:2206]

Gruneberg H. 1952. . In: The Genetics of the Mouse. Martinus Nijhoff, The Hague.  [MGI Ref ID J:30758]

Haldane JBS; Sprunt AD; Haldane NM. 1915. Reduplication in mice J Genet 5:133-135.  [MGI Ref ID J:100]

Lyon MF. 1963. Attempts to test the inactive-X theory of dosage compensation in mammals Genet Res 4:93-103.  [MGI Ref ID J:272]

Lyon MF; King TR; Gondo Y; Gardner JM; Nakatsu Y; Eicher EM; Brilliant MH. 1992. Genetic and molecular analysis of recessive alleles at the pink-eyed dilution (p) locus of the mouse. Proc Natl Acad Sci U S A 89(15):6968-72. [PubMed: 1495987]  [MGI Ref ID J:2108]

Markert CL; Silvers WK. 1956. The Effects of Genotype and Cell Environment on Melanoblast Differentiation in the House Mouse. Genetics 41(3):429-50. [PubMed: 17247639]  [MGI Ref ID J:12970]

Medical Research Council (MRC) Harwell. 2012. Direct Data Submission 2012/01/19_gXj10F MGI Direct Data Submission :.  [MGI Ref ID J:179354]

Moore KJ; Swing DA; Copeland NG; Jenkins NA. 1990. Interaction of the murine dilute suppressor gene (dsu) with fourteen coat color mutations [published erratum appears in Genetics 1990 Sep;126(1):285] Genetics 125(2):421-30. [PubMed: 2379821]  [MGI Ref ID J:29467]

Moyer FH. 1966. Genetic variations in the fine structure and ontogeny of mouse melanin granules. Am Zool 6(1):43-66. [PubMed: 5902512]  [MGI Ref ID J:5001]

Oak Ridge National Laboratory. 2005. Information obtained from the Oak Ridge National Laboratory Mutant Mouse Database (ORNL), Oak Ridge, TN Unpublished :.  [MGI Ref ID J:100221]

PIERRO LJ; CHASE HB. 1963. Slate--a new coat color mutant in the mouse. J Hered 54:47-50. [PubMed: 13943454]  [MGI Ref ID J:25388]

Pierro LJ; Chase HB. 1965. Temporary hair loss associated with the slate mutation of coat colour in the mouse Nature 205:579-580.  [MGI Ref ID J:83269]

Quevedo WC Jr.; Chase HB. 1958. An analysis of the light mutation of coat color in mice. J Morphol 102:329-345.  [MGI Ref ID J:13094]

RUSSELL ES. 1949. A quantitative histological study of the pigment found in the coat-color mutants of the house mouse; interdependence among the variable granule attributes. Genetics 34(2):133-45. [PubMed: 18117146]  [MGI Ref ID J:148461]

Rinchik EM; Bultman SJ; Horsthemke B; Lee ST; Strunk KM; Spritz RA; Avidano KM; Jong MT; Nicholls RD. 1993. A gene for the mouse pink-eyed dilution locus and for human type II oculocutaneous albinism. Nature 361(6407):72-6. [PubMed: 8421497]  [MGI Ref ID J:3600]

Russell ES. 1948. A Quantitative Histological Study of the Pigment Found in the Coat Color Mutants of the House Mouse. II. Estimates of the Total Volume of Pigment. Genetics 33(3):228-36. [PubMed: 17247280]  [MGI Ref ID J:148462]

Russell ES. 1946. A Quantitative Histological Study of the Pigment Found in the Coat-Color Mutants of the House Mouse. I. Variable Attributes of the Pigment Granules. Genetics 31(3):327-46. [PubMed: 17247200]  [MGI Ref ID J:148463]

Russell ES. 1949. A Quantitative Histological Study of the Pigment Found in the Coat-Color Mutants of the House Mouse. IV. the Nature of the Effects of Genic Substitution in Five Major Allelic Series. Genetics 34(2):146-66. [PubMed: 17247308]  [MGI Ref ID J:12958]

Russell LB; Montgomery CS; Cacheiro NL; Johnson DK. 1995. Complementation analyses for 45 mutations encompassing the pink-eyed dilution (p) locus of the mouse. Genetics 141(4):1547-62. [PubMed: 8601493]  [MGI Ref ID J:29903]

Silvers WK. 1979. The Coat Colors of Mice; A Model for Mammalian Gene Action and Interaction. In: The Coat Colors of Mice. Springer-Verlag, New York.  [MGI Ref ID J:78801]

Wakamatsu K; Hirobe T; Ito S. 2007. High levels of melanin-related metabolites in plasma from pink-eyed dilution mice. Pigment Cell Res 20(3):222-4. [PubMed: 17516930]  [MGI Ref ID J:148667]

Tyr^c-ch related

Anderson PD; Lam MY; Poirier C; Bishop CE; Nadeau JH. 2009. The role of the mouse y chromosome on susceptibility to testicular germ cell tumors. Cancer Res 69(8):3614-8. [PubMed: 19351821]  [MGI Ref ID J:147731]

Beermann F; Ruppert S; Hummler E; Bosch FX; Muller G; Ruther U; Schutz G. 1990. Rescue of the albino phenotype by introduction of a functional tyrosinase gene into mice. EMBO J 9(9):2819-26. [PubMed: 2118105]  [MGI Ref ID J:19279]

Bhattacharya C; Aggarwal S; Zhu R; Kumar M; Zhao M; Meistrich ML; Matin A. 2007. The mouse dead-end gene isoform alpha is necessary for germ cell and embryonic viability. Biochem Biophys Res Commun 355(1):194-9. [PubMed: 17291453]  [MGI Ref ID J:118625]

Cattanach BM. 1961. A chemically-induced variegated-type position effect in the mouse. Z Vererbungsl 92:165-82. [PubMed: 13877379]  [MGI Ref ID J:160128]

Dunn LC. 1936. Studies on multiple allelomorphic series in the house mouse. I. Description of agouti and albino series of allelomorphs J Genet 33:443-53.  [MGI Ref ID J:22600]

Erickson RP; Gluecksohn-Waelsch S; Cori CF. 1968. Glucose-6-phosphatase deficiency caused by radiation-induced alleles at the albino locus in the mouse. Proc Natl Acad Sci U S A 59(2):437-44. [PubMed: 4296364]  [MGI Ref ID J:5063]

Errijgers V; Van Dam D; Gantois I; Van Ginneken CJ; Grossman AW; D'Hooge R; De Deyn PP; Kooy RF. 2007. FVB.129P2-Pde6b(+) Tyr(c-ch)/Ant, a sighted variant of the FVB/N mouse strain suitable for behavioral analysis. Genes Brain Behav 6(6):552-7. [PubMed: 17083330]  [MGI Ref ID J:137779]

Feldman HW. 1935. A fifth allelomorph in the albino series of the house mouse J Mammal 16:207-210.  [MGI Ref ID J:83666]

Feldman HW. 1922. A fourth allelomorph in the albino series in mice Am Naturalist 56:573-574.  [MGI Ref ID J:14850]

Klebig ML; Kwon BS; Rinchik EM. 1992. Physical analysis of murine albino deletions that disrupt liver-specific gene regulation or mesoderm development. Mamm Genome 2(1):51-63. [PubMed: 1543902]  [MGI Ref ID J:1540]

Laiosa MD; Lai ZW; Thurmond TS; Fiore NC; DeRossi C; Holdener BC; Gasiewicz TA; Silverstone AE. 2002. 2,3,7,8-tetrachlorodibenzo-p-dioxin causes alterations in lymphocyte development and thymic atrophy in hemopoietic chimeras generated from mice deficient in ARNT2. Toxicol Sci 69(1):117-24. [PubMed: 12215665]  [MGI Ref ID J:113951]

Lamoreux ML; Wakamatsu K; Ito S. 2001. Interaction of major coat color gene functions in mice as studied by chemical analysis of eumelanin and pheomelanin. Pigment Cell Res 14(1):23-31. [PubMed: 11277491]  [MGI Ref ID J:103803]

Lighthouse JK; Zhang L; Hsieh JC; Rosenquist T; Holdener BC. 2010. MESD is essential for apical localization of megalin/LRP2 in the visceral endoderm. Dev Dyn :. [PubMed: 21061374]  [MGI Ref ID J:168622]

Lossie AC; Nakamura H; Thomas SE; Justice MJ. 2005. Mutation of l7Rn3 shows that Odz4 is required for mouse gastrulation. Genetics 169(1):285-99. [PubMed: 15489520]  [MGI Ref ID J:96673]

Lyon MF. 1963. Attempts to test the inactive-X theory of dosage compensation in mammals Genet Res 4:93-103.  [MGI Ref ID J:272]

Medical Research Council (MRC) Harwell. 2012. Direct Data Submission 2012/01/26_RcwkIU MGI Direct Data Submission :.  [MGI Ref ID J:179802]

Moyer FH. 1966. Genetic variations in the fine structure and ontogeny of mouse melanin granules. Am Zool 6(1):43-66. [PubMed: 5902512]  [MGI Ref ID J:5001]

Pietropaolo S; Guilleminot A; Martin B; D'Amato FR; Crusio WE. 2011. Genetic-background modulation of core and variable autistic-like symptoms in Fmr1 knock-out mice. PLoS One 6(2):e17073. [PubMed: 21364941]  [MGI Ref ID J:171069]

RUSSELL ES. 1949. A quantitative histological study of the pigment found in the coat-color mutants of the house mouse; interdependence among the variable granule attributes. Genetics 34(2):133-45. [PubMed: 18117146]  [MGI Ref ID J:148461]

Russell ES. 1948. A Quantitative Histological Study of the Pigment Found in the Coat Color Mutants of the House Mouse. II. Estimates of the Total Volume of Pigment. Genetics 33(3):228-36. [PubMed: 17247280]  [MGI Ref ID J:148462]

Russell ES. 1946. A Quantitative Histological Study of the Pigment Found in the Coat-Color Mutants of the House Mouse. I. Variable Attributes of the Pigment Granules. Genetics 31(3):327-46. [PubMed: 17247200]  [MGI Ref ID J:148463]

Schedl A; Ruppert S; Kelsey G; Thies E; Niswander L; Magnuson T; Klebig ML; Rinchik EM; Schutz G. 1992. Chromosome jumping from flanking markers defines the minimal region for alf/hsdr-1 within the albino-deletion complex. Genomics 14(2):288-97. [PubMed: 1427845]  [MGI Ref ID J:2638]

Silvers WK. 1979. The Coat Colors of Mice; A Model for Mammalian Gene Action and Interaction. In: The Coat Colors of Mice. Springer-Verlag, New York.  [MGI Ref ID J:78801]

Strumbos JG; Brown MR; Kronengold J; Polley DB; Kaczmarek LK. 2010. Fragile X mental retardation protein is required for rapid experience-dependent regulation of the potassium channel Kv3.1b. J Neurosci 30(31):10263-71. [PubMed: 20685971]  [MGI Ref ID J:162850]

Sweet HO. 1987. Acromelanic (c<a>) Mouse News Lett 78:56.  [MGI Ref ID J:14994]

Takeuchi S; Yamamoto H; Takeuchi T. 1988. Expression of tyrosinase gene in mice Genome 30(Suppl 1):260 (Abstr.).  [MGI Ref ID J:30744]

Townsend D; Witkop CJ Jr; Mattson J. 1981. Tyrosinase subcellular distribution and kinetic parameters in wild type and C-locus mutant C57BL/6J mice. J Exp Zool 216(1):113-9. [PubMed: 6793688]  [MGI Ref ID J:6611]

Vasiliou V; Buetler T; Eaton DL; Nebert DW. 2000. Comparison of oxidative stress response parameters in newborn mouse liver versus simian virus 40 (SV40)-transformed hepatocyte cell lines. Biochem Pharmacol 59(6):703-12. [PubMed: 10677587]  [MGI Ref ID J:60274]

Vasiliou V; Reuter SF; Nebert DW. 1997. Extrahepatic expression of NAD(P)H:menadione oxidoreductase, UDP glucuronosyltransferase-1A6, microsomal aldehyde dehydrogenase, and hepatic nuclear factor-1 alpha mRNAs in ch/ch and 14CoS/14CoS mice. Biochem Biophys Res Commun 233(3):631-6. [PubMed: 9168903]  [MGI Ref ID J:40515]

Wu M; Rinchik EM; Wilkinson E; Johnson DK. 1997. Inherited somatic mosaicism caused by an intracisternal A particle insertion in the mouse tyrosinase gene. Proc Natl Acad Sci U S A 94(3):890-4. [PubMed: 9023352]  [MGI Ref ID J:38209]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, RG10/RG30.

Colony Maintenance

Mating System

Progeny Tested         (Female x Male)   13-FEB-08

TJL Breeding Scheme: progeny test; for Dll3pu: heterozygote x heterozygote in repulsion with Oca2p; for Oca2p: heterozygote x heterozygote in repulsion with Dll3pu; for Tyrc-ch: homozygote x homozygote TJL Breeding Summary: this strain is maintained with Dll3pu and Oca2p in repulsion via a progeny test in which ? + Tyrc-ch/+ ? Tyrc-ch are progeny tested then bred Dll3pu+Tyrc-ch/+ Oca2pTyrc-ch x Dll3pu+Tyrc-ch/+ Oca2pTyrc-ch.

Purchasing information

Pricing, Supply Level & Notes, Controls

General Supply Notes

• This strain is included in the Mouse Mutant Resource collection.
• Genomic DNA is available for this strain from the Mouse DNA Resource.

Control Information

	Control
	Untyped from the colony
Considerations for Choosing Controls
Control Pricing Information for Genetically Engineered Mutant Strains.

Important Note

This strain is homozygous for Tyr^c-ch and segregating for Dll3^pu and Oca2^p which are maintained in repulsion.

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Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.

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The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

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