Strain Name:

STOCK Dll3pu + Tyrc-ch/+ Oca2p Tyrc-ch/J

Stock Number:

000306

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Availability:

Cryopreserved - Ready for recovery

Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Former Names STOCK Dll3pu + Tyrc-ch/+ p Tyrc-ch/J    (Changed: 11-FEB-08 )
Type Mutant Stock; Radiation Induced Mutation; Spontaneous Mutation;
Additional information on Genetically Engineered and Mutant Mice.
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Mating SystemProgeny Tested         (Female x Male)   13-FEB-08
TJL Breeding Scheme: progeny test; for Dll3pu: heterozygote x heterozygote in repulsion with Oca2p; for Oca2p: heterozygote x heterozygote in repulsion with Dll3pu; for Tyrc-ch: homozygote x homozygote

TJL Breeding Summary: this strain is maintained with Dll3pu and Oca2p in repulsion via a progeny test in which ? + Tyrc-ch/+ ? Tyrc-ch are progeny tested then bred Dll3pu+Tyrc-ch/+ Oca2pTyrc-ch x Dll3pu+Tyrc-ch/+ Oca2pTyrc-ch.

Specieslaboratory mouse
GenerationF14
Generation Definitions

Appearance
pink-eyed fawn, pudgy
Related Genotype: Dll3pu Oca2p Tyrc-ch/Dll3pu Oca2p Tyrc-ch

pink-eyed fawn, unaffected
Related Genotype: + Oca2p Tyrc-ch/? Oca2p Tyrc-ch

chinchilla, unaffected
Related Genotype: ? + Tyrc-ch/+ ? Tyrc-ch

chinchilla, pudgy
Related Genotype: Dll3pu ? Tyrc-ch/Dll3pu + Tyrc-ch

Important Note
This strain is homozygous for Tyrc-ch and segregating for Dll3pu and Oca2p which are maintained in repulsion.

Development
Pudgy (Dll3pu) arose in the descendants of an x-rayed (101/Rl x C3H/Rl)F1 male from the specific locus experiments at Oak Ridge National Laboratory prior to 1961. It is located on Chromosome 7 linked to pink eyed dilution (Oca2p) and chinchilla (Tyrc-ch). The pudgy stock with Oca2p and Tyrc-ch was imported into The Jackson Laboratory from Dr. L.B. Russell at Oak Ridge in 1961. It was maintained as a close (not inbred) stock by mating Dll3pu + Tyrc-ch/Dll3pu + Tyrc-ch males to + Oca2p Tyrc-ch/+ Oca2p Tyrc-ch females in one generation followed by Dll3pu + Tyrc-ch/+ Oca2p Tyrc-ch matings the next generation until 1983 and then it was sibling mated using the same alternating generations. It was cryopreserved in 1983 using Dll3pu + Tyrc-ch/+ Oca2p Tyrc-ch males x Dll3pu + Tyrc-ch/+ Oca2p Tyrc-ch or untested females at F13.

Control Information

  Control
   Untyped from the colony
 
  Considerations for Choosing Controls

Related Strains

Strains carrying   Oca2p allele
000004   ABP/LeJ
000577   B6 x STOCK a Oca2p Hps5ru2 Ednrbs/J
001059   B6By.Cg-Oca2p/J
000619   FS/EiJ
001618   STOCK Oca2p Prop1df/J
View Strains carrying   Oca2p     (5 strains)

Strains carrying   Tyrc-ch allele
000091   129T1/Sv-Oca2+ Tyrc-ch Dnd1Ter/J
000578   B6 x STOCK Tyrc-ch Bmp5se +/+ Myo6sv/J
000619   FS/EiJ
004624   FVB.129P2-Pde6b+ Tyrc-ch Fmr1tm1Cgr/J
004828   FVB.129P2-Pde6b+ Tyrc-ch/AntJ
000271   SH1/LeJ
View Strains carrying   Tyrc-ch     (6 strains)

Strains carrying other alleles of Dll3
005040   STOCK Tg(Pfkl)224Yg/J-Dll3pu-J/GrsrJ
View Strains carrying other alleles of Dll3     (1 strain)

View Strains carrying other alleles of Oca2     (17 strains)

Strains carrying other alleles of Tyr
000090   129S1/Sv-Oca2+ Tyr+ KitlSl-J/J
005445   A.B6 Tyr+-Cybanmf333/J
005012   A.B6 Tyr+-Myo5ad-l31J/J
002565   A.B6-Tyr+/J
001017   AKXD10/TyJ
000765   AKXD13/TyJ
000954   AKXD15/TyJ
000958   AKXD16/TyJ
001093   AKXD18/TyJ
001062   AKXD21/TyJ
000947   AKXD22/TyJ
000969   AKXD24/TyJ
000777   AKXD6/TyJ
000763   AKXD9/TyJ
000409   B10.129P-H1b Hbbd Tyrc Ea7a/(5M)oSnJ
000418   B10.129P-H1b Tyrc Hbbd/(5M)nSnJ
000432   B10.C-H1b Hbbd Tyrc/(41N)SnJ
000580   B10.D2/nSn-Tyrc-4J/J
000822   B6 x 129S1/SvEi Oca2+ Tyr+-Vsx2or-J/J
017614   B6(Cg)-Tyrc-2J Tg(UBC-mCherry)1Phbs/J
000058   B6(Cg)-Tyrc-2J/J
008647   B6.129P2(Cg)-Trpa1tm1.1Kykw Tyrc-2J/J
000383   B6.C-Tyrc H1b Hbbd/ByJ
013590   B6.Cg-Braftm1Mmcm Ptentm1Hwu Tg(Tyr-cre/ERT2)13Bos/BosJ
003819   B6.Cg-Per2tm1Brd Tyrc-Brd/J
023429   B6.Cg-Tyrc-2J Cdkn1atm1Hpw/J
007484   B6.Cg-Tyrc-2J Tg(Tyr)3412ARpw Tg(Sry-EGFP)92Ei/EiJ
000035   B6.Cg-Tyrc-J/J
000104   B6.Cg-Tyrc-h/J
005349   B6.Cg-awag Tyrc-2J/GrsrJ
012328   B6.Cg-Tg(Tyr-cre/ERT2)13Bos/J
000054   B6.D2-Tyrc-p/J
023428   B6;129X1-Tyrc-2J Cdkn1atm2Hpw/J
000899   C.B6-Tyr+ Hbbs/J
000339   C3H/HeJ-Tyrc-9J/J
001294   C3H/HeJ-Tyrc-a/J
001002   C57BL/10SnJ-Tyrc-11J/J
012257   CB6-Tg(Tyr-TAg)BJjw/Mmjax
001006   CBA/J-Tyrc-10J/J
000657   CE/J
007483   FVB.Cg-Tg(Tyr)3412ARpw Tg(Sry-EGFP)92Ei/EiJ
000494   J.Cg-Oca2+ Tyr+ Lystbg/J
002281   NFS.C58-Tyr+/J
004304   NOD.CBALs-Tyr+/LtJ
001759   STOCK A Tyrc Sha/J
018129   STOCK Fah1R Tyrc/RJ
000006   STOCK Hk Tyrc/J
014173   STOCK Omptm1.1(COP4*/EYFP)Tboz/J
000206   STOCK a/a Tyrc-h/J
View Strains carrying other alleles of Tyr     (49 strains)

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested.
Albinism, Ocular, with Sensorineural Deafness   (TYR)
Albinism, Oculocutaneous, Type IA; OCA1A   (TYR)
Albinism, Oculocutaneous, Type IB; OCA1B   (TYR)
Albinism, Oculocutaneous, Type II; OCA2   (OCA2)
Spondylocostal Dysostosis 1, Autosomal Recessive; SCDO1   (DLL3)
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

Dll3pu/Dll3pu

        involves: 101/Rl * C3H/Rl
  • mortality/aging
  • partial postnatal lethality
    • reduced viability after birth   (MGI Ref ID J:14975)
  • growth/size/body phenotype
  • decreased body length
    • the whole trunk region is shortened   (MGI Ref ID J:14975)
  • embryogenesis phenotype
  • abnormal somite development
    • homozygotes exhibit defective segmentation; although the paraxial mesoderm forms somite tissue with an epithelially arranged outer layer, this material either shows only an abortive segmentation into somites or, in the tail, none at all   (MGI Ref ID J:14975)
    • somites are not clearly defined along the tail, are irregular in shape, and the intersegmental fissures are less well defined   (MGI Ref ID J:14975)
    • presomitic mesoderm is thickened and disorganized at E9.5 and segmental borders between epithelial somites are not formed   (MGI Ref ID J:48518)
    • abnormal rostral-caudal patterning of the somites
      • the boundaries between rostral-caudal compartments within somites are severely disrupted as indicated by abnormal spatial localization of various gene markers   (MGI Ref ID J:48518)
    • abnormal somite shape   (MGI Ref ID J:14975)
      • somites appear irregular in shape   (MGI Ref ID J:48518)
    • abnormal somite size
      • somites appear irregular in size   (MGI Ref ID J:48518)
    • delayed somite formation
      • in the tail, the paraxial mesoderm is formed into solid somite tissue with some delay and in a less orderly fashion   (MGI Ref ID J:14975)
  • skeleton phenotype
  • abnormal cranium morphology
    • anomalies in the skull in the immediate vicinity of the foramen magnum   (MGI Ref ID J:14975)
  • abnormal rib morphology
    • ribs are irregular, particularly in the caudal half of the thoracic region, where the ribs tend to be bunched together   (MGI Ref ID J:14975)
    • rib bifurcation   (MGI Ref ID J:48518)
    • rib fusion   (MGI Ref ID J:48518)
      • irregular rib fusions   (MGI Ref ID J:14975)
  • abnormal sclerotome morphology
    • sclerotome tissue remains continuous and gives rise to abnormal blastema which then chondrify and ossify   (MGI Ref ID J:14975)
  • abnormal vertebrae morphology
    • vertebral column consists of a jumble of vertebrae and fragments of vertebrae   (MGI Ref ID J:14975)
    • deformed vertebrae   (MGI Ref ID J:48518)
    • decreased caudal vertebrae number   (MGI Ref ID J:14975)
    • vertebral fusion
      • highly irregular fusions between vertebrae and fragments of vertebrae   (MGI Ref ID J:14975)
  • kyphosis   (MGI Ref ID J:14975)
  • lordosis   (MGI Ref ID J:14975)
  • short vertebral column
    • shortened all along its length   (MGI Ref ID J:14975)
  • sternebra fusion
    • fusions between adjacent sternebrae, often at an angle, are common   (MGI Ref ID J:14975)
  • muscle phenotype
  • abnormal dermomyotome development
    • segmentation into the dermomyotome is belated   (MGI Ref ID J:14975)
  • nervous system phenotype
  • abnormal brain ependyma morphology
    • 3 of 6 adults show unusual unilateral and bilateral cysts in the lateral ventricular ependymal linings   (MGI Ref ID J:48518)
  • abnormal dorsal root ganglion morphology
    • spinal ganglia are irregularly formed and unevenly spaced   (MGI Ref ID J:48518)
    • fused dorsal root ganglion
      • spinal ganglia is an almost continuous mass instead of being separate from each other as in wild-type   (MGI Ref ID J:14975)
  • abnormal spinal nerve morphology
    • spinal nerves are irregularly formed and unevenly spaced   (MGI Ref ID J:48518)
  • limbs/digits/tail phenotype
  • decreased caudal vertebrae number   (MGI Ref ID J:14975)
  • short tail
    • tail is reduced to a small stub or is all but absent   (MGI Ref ID J:14975)
  • thin tail
    • tails are thinner distally and are pointed at the tip at E14   (MGI Ref ID J:14975)
  • behavior/neurological phenotype
  • abnormal sexual interaction
    • mutants are poor breeders   (MGI Ref ID J:14975)
  • craniofacial phenotype
  • abnormal cranium morphology
    • anomalies in the skull in the immediate vicinity of the foramen magnum   (MGI Ref ID J:14975)

Dll3pu/Dll3pu

        involves: 101/Rl * C3H/He * C3H/Rl * C57BL/6
  • growth/size/body phenotype
  • decreased body length
    • truncation of the body   (MGI Ref ID J:75954)
  • limbs/digits/tail phenotype
  • short tail
    • tail is short, however it is longer than in Dll3tm1Rbe homozygous embryos   (MGI Ref ID J:75954)
  • skeleton phenotype
  • abnormal skeleton morphology
    • at E14.5, defects in the preskeleton are very similar to those of Dll3tm1Rbe homozygous embryos   (MGI Ref ID J:75954)
    • skeletal dysplasia of embryos is less severe than seen in Dll3tm1Rbe homozygous embryos   (MGI Ref ID J:75954)
    • abnormal vertebrae morphology
      • misaligned vertebrae   (MGI Ref ID J:75954)
    • rib fusion   (MGI Ref ID J:75954)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Dll3pu related

Developmental Biology Research
Neurodevelopmental Defects
Skeletal Defects

Oca2p related

Dermatology Research
Color and White Spotting Defects

Neurobiology Research
Angelman syndrome

Tyrc-ch related

Dermatology Research
Color and White Spotting Defects

Developmental Biology Research
Neurodevelopmental Defects
Skeletal Defects

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Dll3pu
Allele Name pudgy
Allele Type Radiation induced
Common Name(s) pu;
Strain of Origin(101/Rl x C3H/Rl)F1
Gene Symbol and Name Dll3, delta-like 3 (Drosophila)
Chromosome 7
Gene Common Name(s) SCDO1; pu; pudgy;
General Note The pudgy mutation appeared in descendants of an X-rayed male at the Oak Ridge National Laboratory. (J:14975). It has been suggested that Dll3pu may be a recurrence of stub (sb), a skeletal mutant now extinct (J:245).
Molecular Note Sequencing of Dll3 shows that Dll3pu mutants have a 4 bp deletion in the third exon leading to a frameshift and early truncation of the expected Dll3 product ahead of the conserved DSL domain. [MGI Ref ID J:48518]
 
Allele Symbol Oca2p
Allele Name pink-eyed dilution
Allele Type Spontaneous
Common Name(s) p;
Strain of OriginAsiatic fancy mice
Gene Symbol and Name Oca2, oculocutaneous albinism II
Chromosome 7
Gene Common Name(s) BEY; BEY1; BEY2; BOCA; D15S12; D7H15S12; D7Icr28RN; D7Nic1; DNA segment, Chr 7, Institute for Cancer Research 28RN; DNA segment, Chr 7, Nicholls 1; DNA segment, Chr 7, human D15S12; EYCL; EYCL2; EYCL3; HCL3; P; PED; SHEP1; p; pink-eyed dilution;
General Note

p is a very old mutation carried in many varieties of fancy mice (J:12958). It has been suggested that the original mutation occurred in Japanese wild mice, Mus musculus molossinus (J:19782).

Homozygotes have pink eyes with pigmentation very much reduced but not completely absent in both the retina and choroid. The black pigment of the hair is very much diluted, but the yellow pigment is only slightly affected. Pigment granules are irregular and shred-like in shape. The small amount of pigment they contain is of wild-type color (J:12970, J:12958). The fine structure of the pigment granules was said by Moyer (J:5001) to be disrupted, but Hearing et al. (J:5346) found the structure to be normal, with premature termination of the melanization process.

In tissue culture of the eye, the amount of pigment formed can be increased by increasing the concentration of tyrosine. This suggests that p may block the melanin-synthesizing pathway by interference with tyrosine supply (J:12726). The site of gene action is in the melanocytes and not in either the dermis or the epidermis (J:7988).

A presumed p gene has been cloned (J:2206). It was isolated from mouse melanoma and melanocyte libraries and is missing or altered in six independent p mutant alleles (J:2206). By sequence comparison, the human P locus, deletions of which are associated with hypopigmentation, is orthologous to p (J:2206). P maps to Chr 15q, near the Prader--Willi syndrome locus. On the basis of this location, the p mutation has been proposed to provide a mouse model for Prader--Willi syndrome, for Angelman syndrome, for one form of hypomelanosis of Ito (J:3253), and for type II oculocutaneous albinism (J:3600). A small nuclear ribonucleoprotein particle gene Snrpn maps near p and its human ortholog in the homologous Prader--Willi region of human Chromosome 15 (J:3623). Snrpn appears to be a better candidate for the Prader-Willi syndrome ortholog. P is deleted in human type II oculocutaneous albinism, making p a model for this disease (J:3600).

 
Allele Symbol Tyrc-ch
Allele Name chinchilla
Allele Type Spontaneous
Common Name(s) cch; cr;
Strain of Originfancier's stock
Gene Symbol and Name Tyr, tyrosinase
Chromosome 7
Gene Common Name(s) ATN; C; CMM8; OCA1; OCA1A; OCAIA; SHEP3; albino; c; skc35; skin/coat color 35;
Molecular Note The mutation in the chinchilla allele was found to be a G to A point mutation that results in an amino acid change at position 464 from alanine to threonine. [MGI Ref ID J:19279]

Genotyping

Genotyping Information


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Additional References

Gridley T. 2003. Notch signaling and inherited disease syndromes. Hum Mol Genet 12(Suppl 1):R9-R13. [PubMed: 12668592]  [MGI Ref ID J:82719]

Dll3pu related

Chen J; Kang L; Zhang N. 2005. Negative feedback loop formed by Lunatic fringe and Hes7 controls their oscillatory expression during somitogenesis. Genesis 43(4):196-204. [PubMed: 16342160]  [MGI Ref ID J:104451]

Dunn LC; Gluecksohn-Schoenheimer S. 1942. Stub, a new mutation in the mouse with marked effects on the spinal column J Hered 33:235-9.  [MGI Ref ID J:245]

Dunwoodie SL; Clements M; Sparrow DB; Sa X; Conlon RA; Beddington RS. 2002. Axial skeletal defects caused by mutation in the spondylocostal dysplasia/pudgy gene Dll3 are associated with disruption of the segmentation clock within the presomitic mesoderm. Development 129(7):1795-806. [PubMed: 11923214]  [MGI Ref ID J:75954]

Gruneberg H. 1961. Genetical studies on the skeleton of the mouse. XXIX. Pudgy Genet Res 2:384-93.  [MGI Ref ID J:14975]

Hartman BH; Hayashi T; Nelson BR; Bermingham-McDonogh O; Reh TA. 2007. Dll3 is expressed in developing hair cells in the mammalian cochlea. Dev Dyn 236(10):2875-83. [PubMed: 17823936]  [MGI Ref ID J:125514]

Kusumi K; Dunwoodie SL; Krumlauf R. 2001. Dynamic expression patterns of the pudgy/spondylocostal dysostosis gene Dll3 in the developing nervous system. Mech Dev 100(1):141-4. [PubMed: 11118901]  [MGI Ref ID J:88448]

Kusumi K; Mimoto MS; Covello KL; Beddington RS; Krumlauf R; Dunwoodie SL. 2004. Dll3 pudgy mutation differentially disrupts dynamic expression of somite genes. Genesis 39(2):115-21. [PubMed: 15170697]  [MGI Ref ID J:107136]

Kusumi K; Sun ES; Kerrebrock AW; Bronson RT; Chi DC; Bulotsky MS ; Spencer JB ; Birren BW ; Frankel WN ; Lander ES. 1998. The mouse pudgy mutation disrupts Delta homologue Dll3 and initiation of early somite boundaries. Nat Genet 19(3):274-8. [PubMed: 9662403]  [MGI Ref ID J:48518]

Machka C; Kersten M; Zobawa M; Harder A; Horsch M; Halder T; Lottspeich F; Hrabe de Angelis M; Beckers J. 2005. Identification of Dll1 (Delta1) target genes during mouse embryogenesis using differential expression profiling. Gene Expr Patterns 6(1):94-101. [PubMed: 15979417]  [MGI Ref ID J:103128]

Nelson BR; Hartman BH; Ray CA; Hayashi T; Bermingham-McDonogh O; Reh TA. 2009. Acheate-scute like 1 (Ascl1) is required for normal delta-like (Dll) gene expression and notch signaling during retinal development. Dev Dyn 238(9):2163-2178. [PubMed: 19191219]  [MGI Ref ID J:151457]

Schubert FR; Tremblay P; Mansouri A; Faisst AM; Kammandel B; Lumsden A; Gruss P; Dietrich S. 2001. Early mesodermal phenotypes in splotch suggest a role for Pax3 in the formation of epithelial somites. Dev Dyn 222(3):506-21. [PubMed: 11747084]  [MGI Ref ID J:72525]

Schwarting GA; Gridley T; Henion TR. 2007. Notch1 expression and ligand interactions in progenitor cells of the mouse olfactory epithelium. J Mol Histol 38(6):543-53. [PubMed: 17605079]  [MGI Ref ID J:130594]

William DA; Saitta B; Gibson JD; Traas J; Markov V; Gonzalez DM; Sewell W; Anderson DM; Pratt SC; Rappaport EF; Kusumi K. 2007. Identification of oscillatory genes in somitogenesis from functional genomic analysis of a human mesenchymal stem cell model. Dev Biol 305(1):172-86. [PubMed: 17362910]  [MGI Ref ID J:121317]

Oca2p related

Brilliant MH; Ching A; Nakatsu Y; Eicher EM. 1994. The original pink-eyed dilution mutation (p) arose in Asiatic mice: implications for the H4 minor histocompatibility antigen, Myod1 regulation and the origin of inbred strains. Genetics 138(1):203-11. [PubMed: 8001787]  [MGI Ref ID J:19782]

Cattanach BM. 1961. A chemically-induced variegated-type position effect in the mouse. Z Vererbungsl 92:165-82. [PubMed: 13877379]  [MGI Ref ID J:160128]

Clement Y; Prut L; Saurini F; Mineur YS; Le Guisquet AM; Vedrine S; Andres C; Vodjdani G; Belzung C. 2012. Gabra5-gene haplotype block associated with behavioral properties of the full agonist benzodiazepine chlordiazepoxide. Behav Brain Res 233(2):474-82. [PubMed: 22677273]  [MGI Ref ID J:190469]

Cook MN; Dunning JP; Wiley RG; Chesler EJ; Johnson DK; Miller DR; Goldowitz D. 2007. Neurobehavioral mutants identified in an ENU-mutagenesis project. Mamm Genome 18(8):559-72. [PubMed: 17629744]  [MGI Ref ID J:125716]

Feldman HW. 1924. Linkage of Albino Allelomorphs in Rats and Mice. Genetics 9(5):487-92. [PubMed: 17246054]  [MGI Ref ID J:93]

Gardner JM; Nakatsu Y; Gondo Y; Lee S; Lyon MF; King RA; Brilliant MH. 1992. The mouse pink-eyed dilution gene: association with human Prader-Willi and Angelman syndromes. Science 257(5073):1121-4. [PubMed: 1509264]  [MGI Ref ID J:2206]

Gruneberg H. 1952. . In: The Genetics of the Mouse. Martinus Nijhoff, The Hague.  [MGI Ref ID J:30758]

Haldane JBS; Sprunt AD; Haldane NM. 1915. Reduplication in mice J Genet 5:133-135.  [MGI Ref ID J:100]

Lyon MF. 1963. Attempts to test the inactive-X theory of dosage compensation in mammals Genet Res 4:93-103.  [MGI Ref ID J:272]

Lyon MF; King TR; Gondo Y; Gardner JM; Nakatsu Y; Eicher EM; Brilliant MH. 1992. Genetic and molecular analysis of recessive alleles at the pink-eyed dilution (p) locus of the mouse. Proc Natl Acad Sci U S A 89(15):6968-72. [PubMed: 1495987]  [MGI Ref ID J:2108]

Markert CL; Silvers WK. 1956. The Effects of Genotype and Cell Environment on Melanoblast Differentiation in the House Mouse. Genetics 41(3):429-50. [PubMed: 17247639]  [MGI Ref ID J:12970]

Medical Research Council (MRC) Harwell. 2012. Direct Data Submission 2012/01/19 MGI Direct Data Submission :.  [MGI Ref ID J:179354]

Moore KJ; Swing DA; Copeland NG; Jenkins NA. 1990. Interaction of the murine dilute suppressor gene (dsu) with fourteen coat color mutations [published erratum appears in Genetics 1990 Sep;126(1):285] Genetics 125(2):421-30. [PubMed: 2379821]  [MGI Ref ID J:29467]

Moyer FH. 1966. Genetic variations in the fine structure and ontogeny of mouse melanin granules. Am Zool 6(1):43-66. [PubMed: 5902512]  [MGI Ref ID J:5001]

Oak Ridge National Laboratory. 2005. Information obtained from the Oak Ridge National Laboratory Mutant Mouse Database (ORNL), Oak Ridge, TN Unpublished :.  [MGI Ref ID J:100221]

PIERRO LJ; CHASE HB. 1963. Slate--a new coat color mutant in the mouse. J Hered 54:47-50. [PubMed: 13943454]  [MGI Ref ID J:25388]

Pierro LJ; Chase HB. 1965. Temporary hair loss associated with the slate mutation of coat colour in the mouse Nature 205:579-580.  [MGI Ref ID J:83269]

Quevedo WC Jr.; Chase HB. 1958. An analysis of the light mutation of coat color in mice. J Morphol 102:329-345.  [MGI Ref ID J:13094]

RUSSELL ES. 1949. A quantitative histological study of the pigment found in the coat-color mutants of the house mouse; interdependence among the variable granule attributes. Genetics 34(2):133-45. [PubMed: 18117146]  [MGI Ref ID J:148461]

Rinchik EM; Bultman SJ; Horsthemke B; Lee ST; Strunk KM; Spritz RA; Avidano KM; Jong MT; Nicholls RD. 1993. A gene for the mouse pink-eyed dilution locus and for human type II oculocutaneous albinism. Nature 361(6407):72-6. [PubMed: 8421497]  [MGI Ref ID J:3600]

Russell ES. 1948. A Quantitative Histological Study of the Pigment Found in the Coat Color Mutants of the House Mouse. II. Estimates of the Total Volume of Pigment. Genetics 33(3):228-36. [PubMed: 17247280]  [MGI Ref ID J:148462]

Russell ES. 1946. A Quantitative Histological Study of the Pigment Found in the Coat-Color Mutants of the House Mouse. I. Variable Attributes of the Pigment Granules. Genetics 31(3):327-46. [PubMed: 17247200]  [MGI Ref ID J:148463]

Russell ES. 1949. A Quantitative Histological Study of the Pigment Found in the Coat-Color Mutants of the House Mouse. IV. the Nature of the Effects of Genic Substitution in Five Major Allelic Series. Genetics 34(2):146-66. [PubMed: 17247308]  [MGI Ref ID J:12958]

Russell LB; Montgomery CS; Cacheiro NL; Johnson DK. 1995. Complementation analyses for 45 mutations encompassing the pink-eyed dilution (p) locus of the mouse. Genetics 141(4):1547-62. [PubMed: 8601493]  [MGI Ref ID J:29903]

Silvers WK. 1979. The Coat Colors of Mice; A Model for Mammalian Gene Action and Interaction. In: The Coat Colors of Mice. Springer-Verlag, New York.  [MGI Ref ID J:78801]

Wakamatsu K; Hirobe T; Ito S. 2007. High levels of melanin-related metabolites in plasma from pink-eyed dilution mice. Pigment Cell Res 20(3):222-4. [PubMed: 17516930]  [MGI Ref ID J:148667]

Tyrc-ch related

Anderson PD; Lam MY; Poirier C; Bishop CE; Nadeau JH. 2009. The role of the mouse y chromosome on susceptibility to testicular germ cell tumors. Cancer Res 69(8):3614-8. [PubMed: 19351821]  [MGI Ref ID J:147731]

Beermann F; Ruppert S; Hummler E; Bosch FX; Muller G; Ruther U; Schutz G. 1990. Rescue of the albino phenotype by introduction of a functional tyrosinase gene into mice. EMBO J 9(9):2819-26. [PubMed: 2118105]  [MGI Ref ID J:19279]

Bhattacharya C; Aggarwal S; Zhu R; Kumar M; Zhao M; Meistrich ML; Matin A. 2007. The mouse dead-end gene isoform alpha is necessary for germ cell and embryonic viability. Biochem Biophys Res Commun 355(1):194-9. [PubMed: 17291453]  [MGI Ref ID J:118625]

Cattanach BM. 1961. A chemically-induced variegated-type position effect in the mouse. Z Vererbungsl 92:165-82. [PubMed: 13877379]  [MGI Ref ID J:160128]

Dobkin C; Rabe A; Dumas R; El Idrissi A; Haubenstock H; Brown WT. 2000. Fmr1 knockout mouse has a distinctive strain-specific learning impairment. Neuroscience 100(2):423-9. [PubMed: 11008180]  [MGI Ref ID J:119166]

Dunn LC. 1936. Studies on multiple allelomorphic series in the house mouse. I. Description of agouti and albino series of allelomorphs J Genet 33:443-53.  [MGI Ref ID J:22600]

Erickson RP; Gluecksohn-Waelsch S; Cori CF. 1968. Glucose-6-phosphatase deficiency caused by radiation-induced alleles at the albino locus in the mouse. Proc Natl Acad Sci U S A 59(2):437-44. [PubMed: 4296364]  [MGI Ref ID J:5063]

Errijgers V; Van Dam D; Gantois I; Van Ginneken CJ; Grossman AW; D'Hooge R; De Deyn PP; Kooy RF. 2007. FVB.129P2-Pde6b(+) Tyr(c-ch)/Ant, a sighted variant of the FVB/N mouse strain suitable for behavioral analysis. Genes Brain Behav 6(6):552-7. [PubMed: 17083330]  [MGI Ref ID J:137779]

Feldman HW. 1935. A fifth allelomorph in the albino series of the house mouse J Mammal 16:207-210.  [MGI Ref ID J:83666]

Feldman HW. 1922. A fourth allelomorph in the albino series in mice Am Naturalist 56:573-574.  [MGI Ref ID J:14850]

Klebig ML; Kwon BS; Rinchik EM. 1992. Physical analysis of murine albino deletions that disrupt liver-specific gene regulation or mesoderm development. Mamm Genome 2(1):51-63. [PubMed: 1543902]  [MGI Ref ID J:1540]

Laiosa MD; Lai ZW; Thurmond TS; Fiore NC; DeRossi C; Holdener BC; Gasiewicz TA; Silverstone AE. 2002. 2,3,7,8-tetrachlorodibenzo-p-dioxin causes alterations in lymphocyte development and thymic atrophy in hemopoietic chimeras generated from mice deficient in ARNT2. Toxicol Sci 69(1):117-24. [PubMed: 12215665]  [MGI Ref ID J:113951]

Lamoreux ML; Wakamatsu K; Ito S. 2001. Interaction of major coat color gene functions in mice as studied by chemical analysis of eumelanin and pheomelanin. Pigment Cell Res 14(1):23-31. [PubMed: 11277491]  [MGI Ref ID J:103803]

Lighthouse JK; Zhang L; Hsieh JC; Rosenquist T; Holdener BC. 2010. MESD is essential for apical localization of megalin/LRP2 in the visceral endoderm. Dev Dyn :. [PubMed: 21061374]  [MGI Ref ID J:168622]

Lossie AC; Nakamura H; Thomas SE; Justice MJ. 2005. Mutation of l7Rn3 shows that Odz4 is required for mouse gastrulation. Genetics 169(1):285-99. [PubMed: 15489520]  [MGI Ref ID J:96673]

Lyon MF. 1963. Attempts to test the inactive-X theory of dosage compensation in mammals Genet Res 4:93-103.  [MGI Ref ID J:272]

Medical Research Council (MRC) Harwell. 2012. Direct Data Submission 2012/01/26 MGI Direct Data Submission :.  [MGI Ref ID J:179802]

Moyer FH. 1966. Genetic variations in the fine structure and ontogeny of mouse melanin granules. Am Zool 6(1):43-66. [PubMed: 5902512]  [MGI Ref ID J:5001]

Pietropaolo S; Guilleminot A; Martin B; D'Amato FR; Crusio WE. 2011. Genetic-background modulation of core and variable autistic-like symptoms in Fmr1 knock-out mice. PLoS One 6(2):e17073. [PubMed: 21364941]  [MGI Ref ID J:171069]

RUSSELL ES. 1949. A quantitative histological study of the pigment found in the coat-color mutants of the house mouse; interdependence among the variable granule attributes. Genetics 34(2):133-45. [PubMed: 18117146]  [MGI Ref ID J:148461]

Russell ES. 1948. A Quantitative Histological Study of the Pigment Found in the Coat Color Mutants of the House Mouse. II. Estimates of the Total Volume of Pigment. Genetics 33(3):228-36. [PubMed: 17247280]  [MGI Ref ID J:148462]

Russell ES. 1946. A Quantitative Histological Study of the Pigment Found in the Coat-Color Mutants of the House Mouse. I. Variable Attributes of the Pigment Granules. Genetics 31(3):327-46. [PubMed: 17247200]  [MGI Ref ID J:148463]

Schedl A; Ruppert S; Kelsey G; Thies E; Niswander L; Magnuson T; Klebig ML; Rinchik EM; Schutz G. 1992. Chromosome jumping from flanking markers defines the minimal region for alf/hsdr-1 within the albino-deletion complex. Genomics 14(2):288-97. [PubMed: 1427845]  [MGI Ref ID J:2638]

Silvers WK. 1979. The Coat Colors of Mice; A Model for Mammalian Gene Action and Interaction. In: The Coat Colors of Mice. Springer-Verlag, New York.  [MGI Ref ID J:78801]

Strumbos JG; Brown MR; Kronengold J; Polley DB; Kaczmarek LK. 2010. Fragile X mental retardation protein is required for rapid experience-dependent regulation of the potassium channel Kv3.1b. J Neurosci 30(31):10263-71. [PubMed: 20685971]  [MGI Ref ID J:162850]

Sweet HO. 1987. Acromelanic (c<a>) Mouse News Lett 78:56.  [MGI Ref ID J:14994]

Takeuchi S; Yamamoto H; Takeuchi T. 1988. Expression of tyrosinase gene in mice Genome 30(Suppl 1):260 (Abstr.).  [MGI Ref ID J:30744]

Townsend D; Witkop CJ Jr; Mattson J. 1981. Tyrosinase subcellular distribution and kinetic parameters in wild type and C-locus mutant C57BL/6J mice. J Exp Zool 216(1):113-9. [PubMed: 6793688]  [MGI Ref ID J:6611]

Vasiliou V; Buetler T; Eaton DL; Nebert DW. 2000. Comparison of oxidative stress response parameters in newborn mouse liver versus simian virus 40 (SV40)-transformed hepatocyte cell lines. Biochem Pharmacol 59(6):703-12. [PubMed: 10677587]  [MGI Ref ID J:60274]

Vasiliou V; Reuter SF; Nebert DW. 1997. Extrahepatic expression of NAD(P)H:menadione oxidoreductase, UDP glucuronosyltransferase-1A6, microsomal aldehyde dehydrogenase, and hepatic nuclear factor-1 alpha mRNAs in ch/ch and 14CoS/14CoS mice. Biochem Biophys Res Commun 233(3):631-6. [PubMed: 9168903]  [MGI Ref ID J:40515]

Wu M; Rinchik EM; Wilkinson E; Johnson DK. 1997. Inherited somatic mosaicism caused by an intracisternal A particle insertion in the mouse tyrosinase gene. Proc Natl Acad Sci U S A 94(3):890-4. [PubMed: 9023352]  [MGI Ref ID J:38209]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Colony Maintenance

Mating SystemProgeny Tested         (Female x Male)   13-FEB-08
TJL Breeding Scheme: progeny test; for Dll3pu: heterozygote x heterozygote in repulsion with Oca2p; for Oca2p: heterozygote x heterozygote in repulsion with Dll3pu; for Tyrc-ch: homozygote x homozygote

TJL Breeding Summary: this strain is maintained with Dll3pu and Oca2p in repulsion via a progeny test in which ? + Tyrc-ch/+ ? Tyrc-ch are progeny tested then bred Dll3pu+Tyrc-ch/+ Oca2pTyrc-ch x Dll3pu+Tyrc-ch/+ Oca2pTyrc-ch.

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $3175.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery of Strains Needing Progeny Testing
    At least two untested males and two untested females (two pairs) will be recovered (eight or more mice is typical). The total number of animals provided, their gender and genotype will vary. Untested animals typically are available to ship between 13 and 16 weeks from the date of your order. If the first recovery attempt is unsuccessful, a second recovery will be done, extending the overall recovery time to approximately 25 weeks. Progeny testing is required to identify the genotype of mice of this strain, as a genotyping assay is not available. This type of testing involves breeding the recovered animals and assessing the phenotype of the offspring in order to identify animals carrying the mutation of interest. We can perform the progeny testing for you as a service or we can ship all recovered animals to you for progeny testing at your facility. If you perform the progeny testing, there is NO guarantee that a carrier will be identified. If we perform progeny testing as a service, additional breeding time will be required. In this case, when a male and female (one pair) are identified that carry the mutation, they and their offspring will be shipped. Delivery time for strains requiring progeny testing often exceeds 25 weeks and may take 12 months or more due to the difficulties in breeding some strains. The progeny testing cost is in addition to the recovery cost and is based on the number of boxes used and the time taken to produce the mice identified as carrying the mutation.
    Please note that identified pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation.

    Please contact Customer Service for more information on the cost of progeny testing for a strain: Tel: 1-800-422-6423 or 1-207-288-5845 (from any location). The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
    Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $4127.50
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery of Strains Needing Progeny Testing
    At least two untested males and two untested females (two pairs) will be recovered (eight or more mice is typical). The total number of animals provided, their gender and genotype will vary. Untested animals typically are available to ship between 13 and 16 weeks from the date of your order. If the first recovery attempt is unsuccessful, a second recovery will be done, extending the overall recovery time to approximately 25 weeks. Progeny testing is required to identify the genotype of mice of this strain, as a genotyping assay is not available. This type of testing involves breeding the recovered animals and assessing the phenotype of the offspring in order to identify animals carrying the mutation of interest. We can perform the progeny testing for you as a service or we can ship all recovered animals to you for progeny testing at your facility. If you perform the progeny testing, there is NO guarantee that a carrier will be identified. If we perform progeny testing as a service, additional breeding time will be required. In this case, when a male and female (one pair) are identified that carry the mutation, they and their offspring will be shipped. Delivery time for strains requiring progeny testing often exceeds 25 weeks and may take 12 months or more due to the difficulties in breeding some strains. The progeny testing cost is in addition to the recovery cost and is based on the number of boxes used and the time taken to produce the mice identified as carrying the mutation.
    Please note that identified pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation.

    Please contact Customer Service for more information on the cost of progeny testing for a strain: Tel: 1-800-422-6423 or 1-207-288-5845 (from any location). The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
    Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

General Supply Notes

  • View the complete collection of spontaneous mutants in the Mouse Mutant Resource.

Control Information

  Control
   Untyped from the colony
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

Important Note

This strain is homozygous for Tyrc-ch and segregating for Dll3pu and Oca2p which are maintained in repulsion.

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.


See Terms of Use tab for General Terms and Conditions


The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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phone:207-288-6470

JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

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In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

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In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


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