Strain Name: |
B6.C3-Mgrn1md/J |
|---|---|
Stock Number: |
000309 |
Availability: | Repository-Cryopreserved |
General Terms and Conditions |
| Former Name |
B6.C3-md/+ (Changed: 15-DEC-04
) |
| Genes & Alleles | Mgrn1; Mgrn1md; |
Product Information
Strain Details
Type JAX® GEMM® Strain - Congenic Additional information on JAX® GEMM® Strains. Type JAX® GEMM® Strain - Mutant Strain Type JAX® GEMM® Strain - Spontaneous Mutation Species laboratory mouse Generation N7F14N1p
Mammalian Phenotype Terms assigned by genotype |
Gene & Allele Details
| Allele Symbol | Mgrn1md | ||
|---|---|---|---|
| Allele Name | mahoganoid | ||
| Common Name(s) | md; | ||
| Strain of Origin | C3H/HeJ | ||
| Gene Symbol and Name | Mgrn1, mahogunin, ring finger 1 | ||
| Chromosome | 16 | ||
| Gene Common Name(s) | 2610042J20Rik; KIAA0544; N28182; RGD1311862; RIKEN cDNA 2610042J20 gene; RNF156; expressed sequence N28182; mKIAA0544; mahoganoid; md; nc; non-agouti curly; non-agouti-curly; | ||
| General Note | The original md mutation arose in the C3H/HeJ strain. This gene is similar to mahogany (Atrnmg) in its effects on coat color, but causes less darkening of the back, ears, and tail of agouti mice (J:13379)(J:13791). | ||
| Molecular Note | The mutation in md has been attributed to a 5 kb retroviral insertion located in the intronic region 5' of exon 12. Northern analysis and RT-PCR indicate that the expression of transcript is greatly reduced in these mice. [MGI Ref ID J:80182] | ||
Related Strains
Strains carrying Mgrn1md allele
000001 B6.C3 A/a Mgrn1md/J 000223 C3H/HeJ-Mgrn1md/J 001277 STOCK Mgrn1md Igl-1b Igl1-rlo/J View Strains carrying Mgrn1md (3 strains)
000809 C3H/HeJ-Mgrn1md-2J/J
Additional Web Information
Congenic Nomenclature
Research Applications
This mouse can be used to support research in many areas including:Mgrn1md related
Dermatology Research
Color and White Spotting Defects
Skin and Hair Texture Defects
References
Additional ReferencesPrice and Supply Information
| Strain Name: | B6.C3-Mgrn1md/J |
| Stock Number: | 000309 |
Price Details
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Supply Details
| Standard Supply | Repository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information. |
|---|---|
| Supply Notes |
Cryorecovery - Standard. The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two males and two females (two pairs) will be provided, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the delivery time to approximately 25 weeks. At least one member of each pair will be of known genotype and will carry the mutation if it is a mutant strain. Please note that pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Price represents a repository maintenance fee, which includes the cost of recovery of the strain from the cryopreservation resource and the periodic replacement of the frozen embryos used for recovery. Cryorecovery to establish a Dedicated Supply for greater quantities of mice. |
| Licensing | See General Terms and Conditions below |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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