| ||||||||||||||||||
- Description
- Disease & phenotype
- Genes & alleles
- Genotyping
- Health & care
- References
- Pricing & purchasing
- Terms of use
Description
Strain Information
Former Names B6CBACa-Aw-J/A-EdaTa/O (Changed: 26-JUL-10 ) B6CBACa Aw-J/A-EdaTa/O/J (Changed: 15-MAY-07 ) B6CBACa-Aw-J/A-EdaTa/O (Changed: 15-DEC-04 ) Type Mutant Stock; Spontaneous Mutation; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Mating System Outcross-Intercross (Female x Male) 01-MAR-06 TJL Breeding Scheme: hemizygote x F1 then (X/O) wild type sibling x hemizygote
TJL Breeding Summary: genotypes of breeders are EdaTa/O x B6CBCaF1Aw-J/A in the first generation then +/O x EdaTa/Y in the second generation. Viable offspring produced from the first generation breeder pair are EdaTa/+ females, +/O females, and EdaTa/Y males.
Viable offspring produced from the second generation breeder pair are EdaTa/+ females, normal +/Y males, and EdaTa/O females.Species laboratory mouse Generation N73F2 (01-FEB-11)
Generation DefinitionsAppearance
tabby (yellow coat, no hair on ears and tail, bald patch behind ears, no guard hairs; tails may show epidermal ulcers)
Related Genotype: A/A EdaTa/O females or Aw-J/A? EdaTa/O females or A/A EdaTa/Y males or Aw-J/A? EdaTa/Y males
agouti with mosaic striped coat
Related Genotype: A/A EdaTa/+ females
white-bellied agouti with mosaic striped coat
Related Genotype: Aw-J/A? EdaTa/+ females
agouti, no striping in coat
Related Genotype: A/A +/+ or A/A +/O females or A/A +/Y
white-bellied agouti, no striping in coat
Related Genotype: Aw-J/A? +/+ or Aw-J/A? +/O females or Aw-J/A? +/YDescription
XO or monsomy X mice lack a second sex chromosome. The condition is inherited as an X-linked dominant trait with male lethality. XO mice exhibit some degree of growth retardation, high frequency hearing loss, reduced thyroid activity, reduced body temperature and some behavioral abnormalities. Unlike Turner Syndrome in humans, XO females are fertile. The two-step mating system for this strain (described under Mating System) incorporates the X-linked coat color marker tabby so that mice can be identified by a combination of coat color and sex. This strain may be useful for studies of Turner Syndrome or X-linked recessive alleles.
Control Information
| Control | ||
|---|---|---|
| +/+, EdaTa/+ or +/Y from the colony | ||
| 001201 B6CBACaF1/J-Aw-J/A | (approximate) | |
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying A allele
002083 B6 x B6EiC3 a/A-T(7;16)235Dn/J 000507 B6 x B6EiC3 a/A-Otcspf/J 000628 B6.CE-A Amy1b Amy2a5b/J 004200 B6;CBACa Aw-J/A-Npr2cn-2J/GrsrJ 000604 B6C3 a/A-T(10;13)199H +/+ Lystbg-J/J or Lystbg-2J/J 003301 B6C3FeF1 a/A-Eya1bor/J 006450 B6EiC3 a/A-Vss/GrsrJ 000557 B6EiC3-+ a/LnpUl A/J 000504 B6EiC3Sn a/A-Cacnb4lh/J 000553 B6EiC3Sn a/A-Egfrwa2 Wnt3avt/J 001811 B6EiC3Sn a/A-Otcspf-ash/J 002343 B6EiC3Sn a/A-Otcspf/J 001923 B6EiC3Sn a/A-Ts(417)2Lws TimT(4;17)3Lws/J 000638 C3FeB6 A/Aw-J-Sptbn4qv-J/J 000200 C3FeB6 A/Aw-J-Ankank/J 000283 LT.CAST-A/J 001759 STOCK A Tyrc Sha/J 001145 WSB/EiJ View Strains carrying A (18 strains)
000287 B6CBACa Aw-J/A-Plp1jp EdaTa/J 000569 C57BL/6J-Aw-J-EdaTa +/+ ArTfm/J 000583 STOCK T(X;16)16H +/+ EdaTa
002016 B6(Cg)-Aw-J EdaTa-6J Chr YB6-Sxr/EiJ 001809 B6.Cg-Aw-J EdaTa-6J +/+ ArTfm/J 000552 B6.Cg-Aw-J EdaTa-6J Sxr 001730 B6.Cg-Aw-J EdaTa-6J Sxrb Hya-/J 000841 B6.Cg-Aw-J EdaTa-By/J 001232 C3H/HeJ-EdaTa-5J/J 000338 C57BL/6J Aw-J-EdaTa-6J/J 003112 STOCK EdaTa-5J/J
Additional Web Information
JAX® NOTES, January 1990, 440. Tabby Stocks Available from The Jackson Laboratory.
Phenotype
Phenotype Information
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested. Ectodermal Dysplasia 1, Hypohidrotic, X-Linked; XHED (EDA)
Skin/Hair/Eye Pigmentation, Variation In, 9; SHEP9 (ASIP)
Tooth Agenesis, Selective, X-Linked, 1; STHAGX1 (EDA)
assigned by genotype
EdaTa/Eda+
B6CBACa Aw-J/A-EdaTa/J-XO
- craniofacial phenotype
- abnormal palatal rugae morphology
- mice exhibit abnormalities in the palatal rugae pattern including shortness of rugae, division of rugae, and S-shaped rugae and rugae discoradance (MGI Ref ID J:147677)
- rugae V and VI are most often affected (MGI Ref ID J:147677)
- mice exhibit more ruga VI and VII abnormalities than in homozygotes (MGI Ref ID J:147677)
- mice exhibit fewer ruga V abnormalities than in homozygotes (MGI Ref ID J:147677)
- ruga V is more often absent compared to in homozygotes (MGI Ref ID J:147677)
- ruga IV is S-shaped less often than in homozygotes (MGI Ref ID J:147677)
- digestive/alimentary phenotype
- abnormal palatal rugae morphology
- mice exhibit abnormalities in the palatal rugae pattern including shortness of rugae, division of rugae, and S-shaped rugae and rugae discoradance (MGI Ref ID J:147677)
- rugae V and VI are most often affected (MGI Ref ID J:147677)
- mice exhibit more ruga VI and VII abnormalities than in homozygotes (MGI Ref ID J:147677)
- mice exhibit fewer ruga V abnormalities than in homozygotes (MGI Ref ID J:147677)
- ruga V is more often absent compared to in homozygotes (MGI Ref ID J:147677)
- ruga IV is S-shaped less often than in homozygotes (MGI Ref ID J:147677)
EdaTa/EdaTa
B6CBACa Aw-J/A-EdaTa/J-XO
- craniofacial phenotype
- abnormal palatal rugae morphology
- only 13% of mice exhibit a normal palatal rugae pattern (MGI Ref ID J:147677)
- 32% of mice exhibit different number of rugae on the left and right side compared to 25% of wild-type mice (MGI Ref ID J:147677)
- mice exhibit abnormalities in the palatal rugae pattern including shortness of rugae, absence of rugae, S-shaped rugae, and rugae discordance (MGI Ref ID J:147677)
- rugae V and VI are most often affected (MGI Ref ID J:147677)
- mice exhibit fewer ruga VI and VII abnormalities than in heterozygotes (MGI Ref ID J:147677)
- mice exhibit more ruga V abnormalities than in heterozygotes (MGI Ref ID J:147677)
- ruga V is less often absent compared to in heterozygotes (MGI Ref ID J:147677)
- ruga IV is S-shaped more often than in heterozygotes and wild-type mice (MGI Ref ID J:147677)
- digestive/alimentary phenotype
- abnormal palatal rugae morphology
- only 13% of mice exhibit a normal palatal rugae pattern (MGI Ref ID J:147677)
- 32% of mice exhibit different number of rugae on the left and right side compared to 25% of wild-type mice (MGI Ref ID J:147677)
- mice exhibit abnormalities in the palatal rugae pattern including shortness of rugae, absence of rugae, S-shaped rugae, and rugae discordance (MGI Ref ID J:147677)
- rugae V and VI are most often affected (MGI Ref ID J:147677)
- mice exhibit fewer ruga VI and VII abnormalities than in heterozygotes (MGI Ref ID J:147677)
- mice exhibit more ruga V abnormalities than in heterozygotes (MGI Ref ID J:147677)
- ruga V is less often absent compared to in heterozygotes (MGI Ref ID J:147677)
- ruga IV is S-shaped more often than in heterozygotes and wild-type mice (MGI Ref ID J:147677)
EdaTa/Y
B6CBACa Aw-J/A-EdaTa/J-XO
- craniofacial phenotype
- abnormal palatal rugae morphology
- only 13% of mice exhibit a normal palatal rugae pattern (MGI Ref ID J:147677)
- mice exhibit abnormalities in the palatal rugae pattern including shortness of rugae, absence of rugae, S-shaped rugae, and rugae discordance (MGI Ref ID J:147677)
- rugae V and VI are most often affected (MGI Ref ID J:147677)
- digestive/alimentary phenotype
- abnormal palatal rugae morphology
- only 13% of mice exhibit a normal palatal rugae pattern (MGI Ref ID J:147677)
- mice exhibit abnormalities in the palatal rugae pattern including shortness of rugae, absence of rugae, S-shaped rugae, and rugae discordance (MGI Ref ID J:147677)
- rugae V and VI are most often affected (MGI Ref ID J:147677)
The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.
EdaTa/Eda+
C57BL/6J-Aw-J-EdaTa +/+ ArTfm/J
- craniofacial phenotype
- abnormal palatal rugae morphology
- mice exhibit abnormalities in the palatal rugae pattern including shortness of rugae, division of rugae, and S-shaped rugae and rugae discoradance (MGI Ref ID J:147677)
- rugae V and VI are most often affected (MGI Ref ID J:147677)
- mice exhibit more ruga VI and VII abnormalities than in homozygotes (MGI Ref ID J:147677)
- mice exhibit fewer ruga V abnormalities than in homozygotes (MGI Ref ID J:147677)
- ruga V is more often absent compared to in homozygotes (MGI Ref ID J:147677)
- ruga IV is S-shaped less often than in homozygotes (MGI Ref ID J:147677)
- digestive/alimentary phenotype
- abnormal palatal rugae morphology
- mice exhibit abnormalities in the palatal rugae pattern including shortness of rugae, division of rugae, and S-shaped rugae and rugae discoradance (MGI Ref ID J:147677)
- rugae V and VI are most often affected (MGI Ref ID J:147677)
- mice exhibit more ruga VI and VII abnormalities than in homozygotes (MGI Ref ID J:147677)
- mice exhibit fewer ruga V abnormalities than in homozygotes (MGI Ref ID J:147677)
- ruga V is more often absent compared to in homozygotes (MGI Ref ID J:147677)
- ruga IV is S-shaped less often than in homozygotes (MGI Ref ID J:147677)
EdaTa/Eda+
Background Not Specified
- pigmentation phenotype
- abnormal coat/hair pigmentation (MGI Ref ID J:249)
- absent phaeomelanin
- restricted loss of agouti hair color contributes to the appearance of transverse markings on an agouti background (MGI Ref ID J:249)
- irregular coat pigmentation
- transverse markings are the result of regional loss of phaeomelanin from agouti hairs and absence or significant loss of of zigzag hairs (MGI Ref ID J:249)
- transverse fur striping
- this appearance is the result of regional loss of phaeomelanin from agouti hairs and absence of zigzag hairs (MGI Ref ID J:249)
- integument phenotype
- abnormal coat/hair pigmentation (MGI Ref ID J:249)
- absent phaeomelanin
- restricted loss of agouti hair color contributes to the appearance of transverse markings on an agouti background (MGI Ref ID J:249)
- irregular coat pigmentation
- transverse markings are the result of regional loss of phaeomelanin from agouti hairs and absence or significant loss of of zigzag hairs (MGI Ref ID J:249)
- transverse fur striping
- this appearance is the result of regional loss of phaeomelanin from agouti hairs and absence of zigzag hairs (MGI Ref ID J:249)
- abnormal hair texture
- a result of loss of zigzag type hairs (MGI Ref ID J:249)
- absent zigzag hairs
- transverse markings are most distinct where this hair type is absent (MGI Ref ID J:249)
- decreased zigzag hair amount
- scarse or absent (MGI Ref ID J:249)
- striated fur
EdaTa/Y
Background Not Specified
- craniofacial phenotype
- abnormal nose morphology (MGI Ref ID J:249)
- abnormal nasal cavity morphology
- accumulation of hair in nasal cavities results in "snuffling" (MGI Ref ID J:249)
- limbs/digits/tail phenotype
- abnormal tail morphology
- pigmentation phenotype
- abnormal coat/hair pigmentation (MGI Ref ID J:249)
- absent phaeomelanin
- absence of agouti-banding on dorsal hair results in a dark stripe in that region (MGI Ref ID J:249)
- abnormal skin pigmentation
- noteably delayed (MGI Ref ID J:249)
- respiratory system phenotype
- abnormal nose morphology (MGI Ref ID J:249)
- abnormal nasal cavity morphology
- accumulation of hair in nasal cavities results in "snuffling" (MGI Ref ID J:249)
- vision/eye phenotype
- narrow eye opening (MGI Ref ID J:249)
- integument phenotype
- abnormal coat/ hair morphology (MGI Ref ID J:249)
- abnormal coat/hair pigmentation (MGI Ref ID J:249)
- absent phaeomelanin
- absence of agouti-banding on dorsal hair results in a dark stripe in that region (MGI Ref ID J:249)
- abnormal hair growth
- hair does not develop behind the ears and on the tail (MGI Ref ID J:249)
- abnormal hair texture
- due to the absence of guard-hairs and zig-zag hairs (MGI Ref ID J:249)
- absent guard hair (MGI Ref ID J:249)
- absent zigzag hairs (MGI Ref ID J:249)
- abnormal hair follicle development
- E14-17 embryos lack the complement of prominent hair follicles for this age (MGI Ref ID J:249)
- abnormal skin pigmentation
- noteably delayed (MGI Ref ID J:249)
- abnormal vibrissa number
- thin skin
- noted a few days after birth (MGI Ref ID J:249)
This mouse can be used to support research in many areas including:
EdaTa relatedReproductive Biology Research
Fertility Defects
Turner's syndrome
Dermatology Research
Color and White Spotting Defects
Skin and Hair Texture Defects
Developmental Biology Research
Eye Defects
Mouse/Human Gene Homologs
hypohidrotic ectodermal dysplasia
Sensorineural Research
Eye Defects
Genes & Alleles
Gene & Allele Information provided by MGI
| Allele Symbol | A | ||
|---|---|---|---|
| Allele Name | wild-type agouti | ||
| Allele Type | Spontaneous | ||
| Common Name(s) | dark-bellied agouti; | ||
| Strain of Origin | various | ||
| Gene Symbol and Name | a, nonagouti | ||
| Chromosome | 2 | ||
| Gene Common Name(s) | AGSW; AGTI; AGTIL; ASP; As; SHEP9; agouti; agouti signal protein; agouti suppressor; | ||
| General Note | The A allele is usually regarded as a wild-type allele. The C3H and CBA mouse sublines are homozygous for agouti. Hairs are black with a subapical yellow band. This black-yellow-black pattern is referred to as agouti. The general appearance is yellowish brown, slightly lighter on the belly than on the back. | ||
| Molecular Note | This allele, often referred to as wild-type, comprises a novel 131 amino acid protein encoded in a gene comprising four exons, three coding, spanning 18kb. Unique changes in this gene account for all other alleles that have been molecularly characterized. The expression of this allele is almost always dominant to other alleles of this gene. [MGI Ref ID J:3523] | ||
| Allele Symbol | Aw-J | ||
| Allele Name | white bellied agouti Jackson | ||
| Allele Type | Spontaneous | ||
| Common Name(s) | AWJ; | ||
| Strain of Origin | C57BL/6J | ||
| Gene Symbol and Name | a, nonagouti | ||
| Chromosome | 2 | ||
| Gene Common Name(s) | AGSW; AGTI; AGTIL; ASP; As; SHEP9; agouti; agouti signal protein; agouti suppressor; | ||
| Allele Symbol | EdaTa | ||
| Allele Name | tabby | ||
| Allele Type | Spontaneous | ||
| Common Name(s) | Ta; Ta3; TaFa; Taf; | ||
| Strain of Origin | stock including A, C57BL, CBA, and RIII | ||
| Gene Symbol and Name | Eda, ectodysplasin-A | ||
| Chromosome | X | ||
| Gene Common Name(s) | ECTD1; ED1; ED1-A1; ED1-A2; EDA1; EDA2; Eda-A1; Eda-A2; HED; HED1; ODT1; RGD1563178; STHAGX1; Ta; XHED; XLHED; tabby; | ||
| General Note | This mutation arose in a strain selected for large size. Hemizygous mutant males breed satisfactorily, but homozygous mutant females are often sterile. Hemizygous mutant females are fully fertile (J:249).Hemizygous males and homozygous females are identical in phenotype with homozygous crinkled (Edaraddcr) and downless (Edardl) mice and with homozygous or heterozygous sleek (Dlslk) mice. They are characterized by absence of guard hairs and zigzags in the coat, a bald patch behind the ear, bald tail with a few kinks near the tip, reduced aperture of the eyelids, a respiratory disorder, and a modified agouti pattern (J:249). The number of vibrissae is reduced (J:14912). The incisors may be reduced or absent, and the molars are usually smaller than normal with the third molar often absent (J:5018, J:5138). There are defects of many endocrine glands. The structures affected by the mutation all arise embryologically as downgrowths of solid epithelial cords, not by invagination with a lumen or by outgrowths from deep grooves (J:5246).Hemizygous mutant females are most easily recognized if they are agouti, in which case they show transverse stripes of light-colored normal and dark tabby hair. They have normal incisors but may have mutant or intermediate-type molars (J:5138). A small proportion of heterozygous females may show some slight defects of some of the exocrine glands (J:5193).In the development of the coat of homozygous and hemizygous mutant mice, hair follicle initiation begins at 17 days of gestation, 3 days later than normal, and ends 1 or 2 days after birth, several days earlier than normal. The hairs are of only one type and resemble abnormal awls (J:12100, J:5137). By use of dermal--epidermal recombination grafts of embryonic flank skin, it was shown that EdaTa acts in the epidermis in its effects on structure of the hairs (J:6041). The effect of the mutation in preventing growth of hair on the tail may be either dermal or epidermal. The mutation may act directly on hair cells or via a diffusible product (J:7450). The phenotype of EdaTa/+ females has been extensively studied because of its relevance to the X-inactivation theory of dosage compensation (J:5018, J:5238).EdaTa and the related mutations Edaraddcr and Edardl disrupt normal development of certain epidermal derivatives, including sweat glands. Although the sensory innervation of footpad skin and the sympathetic innervation of blood vessels in the foot pad is normal in these mutants, the sympathetic fibers that normally innervate the sweat glands fail to develop (J:19910).A candidate gene for the human familial X-linked disorder hypohidrotic ectodermal dysplasia (EDA)(OMIM 305100) has been partially cloned. Eda, a candidate for which has also been cloned, is the homologous gene in the mouse, on the basis of phenotype - hypoplasia of sweat glands, teeth, and hair - and of homologous mapping. There is high sequence identity between the cloned portions of the two genes. Known Eda mutations have been identified in the candidate mouse gene. An extracellular collagenous domain of the mouse gene, not yet identified in the EDA gene, may represent the location of mutations in 85-90% of human families (J:42614). A mouse gene Eda (ectodysplasin-A) has been proposed as the site of the tabby mutations (J:44605).Exogenous epidermal growth factor can reverse phenotypic features of EdaTa mice, advancing the delayed opening of eyelids and eruption of incisors (J:42661) and inducing development of dermal ridges and functional sweat glands (J:42660). Expression of epidermal growth factor receptor is reduced in EDA and in EdaTa mice (J:33361). | ||
| Molecular Note | This allele is characterized by an ~ 2 kb deletion: Genomic DNA was hybridized with an exon 1 probe showing a deletion including the coding region and primers for DNA flanking exon 1 failed to amplify in a PCR assay. [MGI Ref ID J:42614] [MGI Ref ID J:44605] | ||
References
References provided by MGI
Selected Reference(s)
Deckers JF; Van der Kroon PH. 1981. Some characteristics of the XO mouse (Mus musculus L.) I. Vitality: Growth adn metabolism Genetica 55:179-185. [MGI Ref ID J:139220]
Green MC. 1967. XO mosaic origin Mouse News Lett 37:33. [MGI Ref ID J:166122]
Lynn PM; Davies W. 2007. The 39,XO mouse as a model for the neurobiology of Turner syndrome and sex-biased neuropsychiatric disorders. Behav Brain Res 179(2):173-82. [PubMed: 17367875] [MGI Ref ID J:120158]
Probst FJ; Cooper ML; Cheung SW; Justice MJ. 2008. Genotype, phenotype, and karyotype correlation in the XO mouse model of Turner Syndrome. J Hered 99(5):512-7. [PubMed: 18499648] [MGI Ref ID J:138994]
Additional References
Aberg T; Wang XP; Kim JH; Yamashiro T; Bei M; Rice R; Ryoo HM; Thesleff I. 2004. Runx2 mediates FGF signaling from epithelium to mesenchyme during tooth morphogenesis. Dev Biol 270(1):76-93. [PubMed: 15136142] [MGI Ref ID J:92174]
Agulnik AI; Harrison WR; Bishop CE. 2001. Smcy transgene does not rescue spermatogenesis in sex-reversed mice. Mamm Genome 12(2):112-6. [PubMed: 11210179] [MGI Ref ID J:69107]
Cattanach BM. 1962. Flecked Mouse News Lett 27:31. [MGI Ref ID J:31415]
Hultcrantz M; Stenberg AE; Fransson A; Canlon B. 2000. Characterization of hearing in an X,0 'Turner mouse'. Hear Res 143(1-2):182-8. [PubMed: 10771195] [MGI Ref ID J:108844]
Jaskoll T; Zhou YM; Trump G; Melnick M. 2003. Ectodysplasin receptor-mediated signaling is essential for embryonic submandibular salivary gland development. Anat Rec A Discov Mol Cell Evol Biol 271(2):322-31. [PubMed: 12629675] [MGI Ref ID J:105968]
Koppinen P; Pispa J; Laurikkala J; Thesleff I; Mikkola ML. 2001. Signaling and subcellular localization of the TNF receptor Edar. Exp Cell Res 269(2):180-92. [PubMed: 11570810] [MGI Ref ID J:71957]
Russell WL; Russell LB; Gower JS. 1959. Exceptional inheritance of a sex-linked gene in the mouse explained on the basis that the X/O sex-chromosome constitution is female. Proc Natl Acad Sci U S A 45(4):554-560. [PubMed: 16590412] [MGI Ref ID J:13126]
A relatedAw-J relatedBlewitt ME; Vickaryous NK; Hemley SJ; Ashe A; Bruxner TJ; Preis JI; Arkell R; Whitelaw E. 2005. An N-ethyl-N-nitrosourea screen for genes involved in variegation in the mouse. Proc Natl Acad Sci U S A 102(21):7629-34. [PubMed: 15890782] [MGI Ref ID J:99816]
Bultman SJ; Michaud EJ; Woychik RP. 1992. Molecular characterization of the mouse agouti locus. Cell 71(7):1195-204. [PubMed: 1473152] [MGI Ref ID J:3523]
Bundschuh VG; Madry M. 1988. [atwp mutation in an albino mouse substrain (AB/Hum-1)] Z Versuchstierkd 31(6):249-54. [PubMed: 3227730] [MGI Ref ID J:16568]
Czyzyk TA; Sikorski MA; Yang L; McKnight GS. 2008. Disruption of the RIIbeta subunit of PKA reverses the obesity syndrome of Agouti lethal yellow mice. Proc Natl Acad Sci U S A 105(1):276-81. [PubMed: 18172198] [MGI Ref ID J:131039]
Dickie MM. 1969. Mutations at the agouti locus in the mouse. J Hered 60(1):20-5. [PubMed: 5798139] [MGI Ref ID J:30922]
Dry FW. 1928. The agouti coloration of the mouse (Mus Musculus) and the rat (Mus Norvegicus). J Genet 20:131-144. [MGI Ref ID J:46318]
Dunn LC. 1945. A New Eye Color Mutant in the Mouse with Asymmetrical Expression. Proc Natl Acad Sci U S A 31(11):343-6. [PubMed: 16578176] [MGI Ref ID J:13122]
Galbraith DB; Wolff GL; Brewer NL. 1979. Tissue microenvironment and the genetic control of hair pigment patterns in mice Dev Genet 1(2):167-179. [MGI Ref ID J:156092]
Guido V; and The Mouse Mutant Resource (MMR) at The Jackson Laboratory. 2002. Two new mutations of white bellied agouti, w-46J and w-47J MGI Direct Data Submission :. [MGI Ref ID J:77218]
Jackson IJ; Budd PS; Keighren M; McKie L. 2007. Humanized MC1R transgenic mice reveal human specific receptor function. Hum Mol Genet 16(19):2341-8. [PubMed: 17652101] [MGI Ref ID J:129904]
Kelly EM. 1957. Beige, bg Mouse News Lett 16:36. [MGI Ref ID J:29744]
Mather K; North SB. 1940. Umbrous: a case of dominance modification in mice. J Genet 40:229-41. [MGI Ref ID J:280]
MouseBookTM. 2005. Information obtained from MouseBook<sup>TM</sup>, Medical Research Council Mammalian Genetics Unit, Harwell, UK. Unpublished :. [MGI Ref ID J:169366]
Perry WL; Copeland NG; Jenkins NA. 1994. The molecular basis for dominant yellow agouti coat color mutations. Bioessays 16(10):705-7. [PubMed: 7980472] [MGI Ref ID J:21244]
Phillips RJS. 1966. A cis-trans position effect at the A locus of the house mouse. Genetics 54(2):485-95. [PubMed: 5968639] [MGI Ref ID J:5027]
Quevedo WC Jr.; Chase HB. 1958. An analysis of the light mutation of coat color in mice. J Morphol 102:329-345. [MGI Ref ID J:13094]
Silvers WK. 1979. The Coat Colors of Mice; A Model for Mammalian Gene Action and Interaction. In: The Coat Colors of Mice. Springer-Verlag, New York. [MGI Ref ID J:78801]
Siracusa LD; Washburn LL; Swing DA; Argeson AC; Jenkins NA; Copeland NG. 1995. Hypervariable yellow (Ahvy), a new murine agouti mutation: Ahvy displays the largest variation in coat color phenotypes of all known agouti alleles. J Hered 86(2):121-8. [PubMed: 7751596] [MGI Ref ID J:24247]
EdaTa relatedAberg T; Wang XP; Kim JH; Yamashiro T; Bei M; Rice R; Ryoo HM; Thesleff I. 2004. Runx2 mediates FGF signaling from epithelium to mesenchyme during tooth morphogenesis. Dev Biol 270(1):76-93. [PubMed: 15136142] [MGI Ref ID J:92174]
Banerjee H; Das A; Srivastava S; Mattoo HR; Thyagarajan K; Khalsa JK; Tanwar S; Das DS; Majumdar SS; George A; Bal V; Durdik JM; Rath S. 2012. A role for apoptosis-inducing factor in T cell development. J Exp Med 209(9):1641-53. [PubMed: 22869892] [MGI Ref ID J:191446]
Barsh GS; Epstein CJ. 1989. Physical and genetic characterization of a 75-kilobase deletion associated with al, a recessive lethal allele at the mouse agouti locus. Genetics 121(4):811-8. [PubMed: 2566558] [MGI Ref ID J:9799]
Baurle J; Vogten H; Grusser-Cornehls U. 1998. Course and targets of the calbindin D-28k subpopulation of primary vestibular afferents. J Comp Neurol 402(1):111-28. [PubMed: 9831049] [MGI Ref ID J:118430]
Boran T; Lesot H; Peterka M; Peterkova R. 2005. Increased apoptosis during morphogenesis of the lower cheek teeth in tabby/EDA mice. J Dent Res 84(3):228-33. [PubMed: 15723861] [MGI Ref ID J:112546]
Chinta SJ; Rane A; Yadava N; Andersen JK; Nicholls DG; Polster BM. 2009. Reactive oxygen species regulation by AIF- and complex I-depleted brain mitochondria. Free Radic Biol Med 46(7):939-47. [PubMed: 19280713] [MGI Ref ID J:145908]
Cui CY; Hashimoto T; Grivennikov SI; Piao Y; Nedospasov SA; Schlessinger D. 2006. Ectodysplasin regulates the lymphotoxin-beta pathway for hair differentiation. Proc Natl Acad Sci U S A 103(24):9142-7. [PubMed: 16738056] [MGI Ref ID J:111051]
Cui CY; Kunisada M; Esibizione D; Grivennikov SI; Piao Y; Nedospasov SA; Schlessinger D. 2007. Lymphotoxin-beta regulates periderm differentiation during embryonic skin development. Hum Mol Genet 16(21):2583-90. [PubMed: 17673451] [MGI Ref ID J:129949]
Cunningham D; Spychala K; McLarren KW; Garza LA; Boerkoel CF; Herman GE. 2009. Developmental expression pattern of the cholesterogenic enzyme NSDHL and negative selection of NSDHL-deficient cells in the heterozygous Bpa(1H)/+ mouse. Mol Genet Metab 98(4):356-66. [PubMed: 19631568] [MGI Ref ID J:155028]
Dickie MM. 1969. Mutations at the agouti locus in the mouse. J Hered 60(1):20-5. [PubMed: 5798139] [MGI Ref ID J:30922]
Esibizione D; Cui CY; Schlessinger D. 2008. Candidate EDA targets revealed by expression profiling of primary keratinocytes from Tabby mutant mice. Gene 427(1-2):42-6. [PubMed: 18848976] [MGI Ref ID J:143603]
Granholm DE; Reese RN; Granholm NH. 1996. Agouti alleles alter cysteine and glutathione concentrations in hair follicles and serum of mice (A y/a, A wJ/A wJ, and a/a). J Invest Dermatol 106(3):559-63. [PubMed: 8648194] [MGI Ref ID J:32132]
Granholm DE; Reese RN; Granholm NH. 1995. Agouti alleles influence thiol concentrations in hair follicles and extrafollicular tissues of mice (Ay/a, AwJ/AwJ, a/a). Pigment Cell Res 8(6):302-6. [PubMed: 8789738] [MGI Ref ID J:31403]
Hisatomi T; Nakao S; Murakami Y; Noda K; Nakazawa T; Notomi S; Connolly E; She H; Almulki L; Ito Y; Vavvas DG; Ishibashi T; Miller JW. 2012. The regulatory roles of apoptosis-inducing factor in the formation and regression processes of ocular neovascularization. Am J Pathol 181(1):53-61. [PubMed: 22613025] [MGI Ref ID J:185543]
Jones JM; Huang JD; Mermall V; Hamilton BA; Mooseker MS; Escayg A; Copeland NG; Jenkins NA; Meisler MH. 2000. The mouse neurological mutant flailer expresses a novel hybrid gene derived by exon shuffling between Gnb5 and Myo5a. Hum Mol Genet 9(5):821-8. [PubMed: 10749990] [MGI Ref ID J:61324]
Kappenman KE; Dvoracek MA; Harvison GA; Fuller BB; Granholm NH. 1992. Tyrosinase abundance and activity in murine hairbulb melanocytes of agouti mutants (C57BL/6J-a/a, Ay/a, and AwJ/AwJ). Pigment Cell Res Suppl 2:79-83. [PubMed: 1409442] [MGI Ref ID J:1295]
Katoh A; Yoshida T; Himeshima Y; Mishina M; Hirano T. 2005. Defective control and adaptation of reflex eye movements in mutant mice deficient in either the glutamate receptor delta2 subunit or Purkinje cells. Eur J Neurosci 21(5):1315-26. [PubMed: 15813941] [MGI Ref ID J:101081]
Knapp PE; Adjan VV; Hauser KF. 2009. Cell-specific loss of kappa-opioid receptors in oligodendrocytes of the dysmyelinating jimpy mouse. Neurosci Lett 451(2):114-8. [PubMed: 19110031] [MGI Ref ID J:146365]
Lee M; Kim A; Chua SC Jr; Obici S; Wardlaw SL. 2007. Transgenic MSH overexpression attenuates the metabolic effects of a high-fat diet. Am J Physiol Endocrinol Metab 293(1):E121-31. [PubMed: 17374695] [MGI Ref ID J:126508]
Lu W; Tsirka SE. 2002. Partial rescue of neural apoptosis in the Lurcher mutant mouse through elimination of tissue plasminogen activator. Development 129(8):2043-50. [PubMed: 11934869] [MGI Ref ID J:111363]
Martin LA; Goldowitz D; Mittleman G. 2010. Repetitive behavior and increased activity in mice with Purkinje cell loss: a model for understanding the role of cerebellar pathology in autism. Eur J Neurosci 31(3):544-55. [PubMed: 20105240] [MGI Ref ID J:159466]
Mayer TC; Fishbane JL. 1972. Mesoderm-ectoderm interaction in the production of the agouti pigmentation pattern in mice. Genetics 71(2):297-303. [PubMed: 4558326] [MGI Ref ID J:5288]
Mitsumori K; Yasuhara K; Mori I; Hayashi S; Shimo T; Onodera H; Nomura T; Hayashi Y. 1998. Pulmonary fibrosis caused by N-methyl-N-nitrosourethane inhibits lung tumorigenesis by urethane in transgenic mice carrying the human prototype c-Ha-ras gene. Cancer Lett 129(2):181-90. [PubMed: 9719460] [MGI Ref ID J:52138]
Monroe DG; Wipf LP; Diggins MR; Matthees DP; Granholm NH. 1998. Agouti-related maturation and tissue distribution of alpha-Melanocyte Stimulating Hormone in wild-type (AwJ/AwJ) and mutant (Ay/a,a/a) mice. Pigment Cell Res 11(5):310-3. [PubMed: 9877102] [MGI Ref ID J:52183]
Mullen RJ. 1974. A<w-J> - white-bellied agouti-J Mouse News Lett 50:38. [MGI Ref ID J:64104]
Mustonen T; Ilmonen M; Pummila M; Kangas AT; Laurikkala J; Jaatinen R; Pispa J; Gaide O; Schneider P; Thesleff I; Mikkola ML. 2004. Ectodysplasin A1 promotes placodal cell fate during early morphogenesis of ectodermal appendages. Development 131(20):4907-19. [PubMed: 15371307] [MGI Ref ID J:128256]
O'donnell SM; Hansberger MW; Connolly JL; Chappell JD; Watson MJ; Pierce JM; Wetzel JD; Han W; Barton ES; Forrest JC; Valyi-Nagy T; Yull FE; Blackwell TS; Rottman JN; Sherry B; Dermody TS. 2005. Organ-specific roles for transcription factor NF-kappaB in reovirus-induced apoptosis and disease. J Clin Invest 115(9):2341-2350. [PubMed: 16100570] [MGI Ref ID J:100906]
Peng J; Wu Z; Wu Y; Hsu M; Stevenson FF; Boonplueang R; Roffler-Tarlov SK; Andersen JK. 2002. Inhibition of caspases protects cerebellar granule cells of the weaver mouse from apoptosis and improves behavioral phenotype. J Biol Chem 277(46):44285-91. [PubMed: 12221097] [MGI Ref ID J:119427]
Peng J; Xie L; Stevenson FF; Melov S; Di Monte DA; Andersen JK. 2006. Nigrostriatal dopaminergic neurodegeneration in the weaver mouse is mediated via neuroinflammation and alleviated by minocycline administration. J Neurosci 26(45):11644-51. [PubMed: 17093086] [MGI Ref ID J:114943]
Poole TW. 1975. Dermal-epidermal interactions and the action of alleles at the agouti locus in the mouse. Dev Biol 42(2):203-10. [PubMed: 1090472] [MGI Ref ID J:5519]
Prtenjaca A; Hill KA. 2011. Mutation frequency is not elevated in the cerebellum of harlequin/Big Blue((R)) mice but Class II deletions occur preferentially in young harlequin cerebellum. Mutat Res 707(1-2):53-60. [PubMed: 21195094] [MGI Ref ID J:168461]
Smith DE; Xu SG. 2003. Ultrastructural organization of GABA-like immunoreactive profiles in the weaver substantia nigra. J Neurocytol 32(3):293-303. [PubMed: 14724391] [MGI Ref ID J:121345]
Vandenput L; Swinnen JV; Boonen S; Van Herck E; Erben RG; Bouillon R; Vanderschueren D. 2004. Role of the androgen receptor in skeletal homeostasis: the androgen-resistant testicular feminized male mouse model. J Bone Miner Res 19(9):1462-70. [PubMed: 15312246] [MGI Ref ID J:111491]
Wu Q; Miller RH; Ransohoff RM; Robinson S; Bu J; Nishiyama A. 2000. Elevated levels of the chemokine GRO-1 correlate with elevated oligodendrocyte progenitor proliferation in the jimpy mutant. J Neurosci 20(7):2609-17. [PubMed: 10729341] [MGI Ref ID J:109469]
Yamago G; Takata Y; Furuta I; Urase K; Momoi T; Huh N. 2001. Suppression of hair follicle development inhibits induction of sonic hedgehog, patched, and patched-2 in hair germs in mice. Arch Dermatol Res 293(9):435-41. [PubMed: 11758785] [MGI Ref ID J:116953]
Yoshida T; Katoh A; Ohtsuki G; Mishina M; Hirano T. 2004. Oscillating Purkinje neuron activity causing involuntary eye movement in a mutant mouse deficient in the glutamate receptor delta2 subunit. J Neurosci 24(10):2440-8. [PubMed: 15014119] [MGI Ref ID J:97010]
Zhang M; Su YQ; Sugiura K; Xia G; Eppig JJ. 2010. Granulosa cell ligand NPPC and its receptor NPR2 maintain meiotic arrest in mouse oocytes. Science 330(6002):366-9. [PubMed: 20947764] [MGI Ref ID J:164870]
van Empel VP; Bertrand AT; van der Nagel R; Kostin S; Doevendans PA; Crijns HJ; de Wit E; Sluiter W; Ackerman SL; De Windt LJ. 2005. Downregulation of apoptosis-inducing factor in harlequin mutant mice sensitizes the myocardium to oxidative stress-related cell death and pressure overload-induced decompensation. Circ Res 96(12):e92-e101. [PubMed: 15933268] [MGI Ref ID J:110278]
Aberg T; Wang XP; Kim JH; Yamashiro T; Bei M; Rice R; Ryoo HM; Thesleff I. 2004. Runx2 mediates FGF signaling from epithelium to mesenchyme during tooth morphogenesis. Dev Biol 270(1):76-93. [PubMed: 15136142] [MGI Ref ID J:92174]
Blecher SR; Kapalanga J; Lalonde D. 1990. Induction of sweat glands by epidermal growth factor in murine X-linked anhidrotic ectodermal dysplasia. Nature 345(6275):542-4. [PubMed: 2348861] [MGI Ref ID J:42660]
Boran T; Lesot H; Peterka M; Peterkova R. 2005. Increased apoptosis during morphogenesis of the lower cheek teeth in tabby/EDA mice. J Dent Res 84(3):228-33. [PubMed: 15723861] [MGI Ref ID J:112546]
Cerghet M; Bessert DA; Nave KA; Skoff RP. 2001. Differential expression of apoptotic markers in jimpy and in Plp overexpressors: evidence for different apoptotic pathways. J Neurocytol 30(9-10):841-55. [PubMed: 12165674] [MGI Ref ID J:121313]
Charles C; Pantalacci S; Peterkova R; Peterka M; Laudet V; Viriot L. 2007. Disruption of the palatal rugae pattern in Tabby (eda) mutant mice. Eur J Oral Sci 115(6):441-8. [PubMed: 18028050] [MGI Ref ID J:147677]
Charles C; Pantalacci S; Tafforeau P; Headon D; Laudet V; Viriot L. 2009. Distinct impacts of Eda and Edar loss of function on the mouse dentition. PLoS ONE 4(4):e4985. [PubMed: 19340299] [MGI Ref ID J:148176]
Claxton JH. 1967. The initiation and development of the hair follicle population in tabby mice. Genet Res 10:161-171. [MGI Ref ID J:12100]
Dulos GJ; Bagchus WM. 2001. Androgens indirectly accelerate thymocyte apoptosis. Int Immunopharmacol 1(2):321-8. [PubMed: 11360932] [MGI Ref ID J:109877]
FALCONER DS. 1953. [Total sex-linkage in the house mouse.] Z Indukt Abstamm Vererbungsl 85(2):210-9. [PubMed: 13103353] [MGI Ref ID J:249]
Falconer DS; Latyszewski M. 1952. The environment in relation to selection for size in mice J Genet 51:67-80. [MGI Ref ID J:78116]
Ferguson BM; Brockdorff N; Formstone E; Ngyuen T; Kronmiller JE; Zonana J. 1997. Cloning of Tabby, the murine homolog of the human EDA gene: evidence for a membrane-associated protein with a short collagenous domain. Hum Mol Genet 6(9):1589-94. [PubMed: 9285798] [MGI Ref ID J:42614]
Fliniaux I; Mikkola ML; Lefebvre S; Thesleff I. 2008. Identification of dkk4 as a target of Eda-A1/Edar pathway reveals an unexpected role of ectodysplasin as inhibitor of Wnt signalling in ectodermal placodes. Dev Biol 320(1):60-71. [PubMed: 18508042] [MGI Ref ID J:138365]
Fraser AS; Kindred BM. 1960. Selection for an invariant character, vibrissa number, in the house mouse. II. Limits to variability Aust J Biol Sci 13:48-58. [MGI Ref ID J:14912]
Gruneberg H. 1965. Genes and genotypes affecting the teeth of the mouse. J Embryol Exp Morphol 14(2):137-59. [PubMed: 5893447] [MGI Ref ID J:12999]
Gruneberg H. 1971. The glandular aspects of the tabby syndrome in the mouse. J Embryol Exp Morphol 25(1):1-19. [PubMed: 5548211] [MGI Ref ID J:5193]
Gruneberg H. 1966. The molars of the tabby mouse, and a test of the 'single-active X-chromosome' hypothesis. J Embryol Exp Morphol 15(2):223-44. [PubMed: 5959976] [MGI Ref ID J:5018]
Gruneberg H. 1971. The tabby syndrome in the mouse. Proc R Soc Lond B Biol Sci 179(55):139-56. [PubMed: 4399988] [MGI Ref ID J:5246]
Gruneberg H. 1969. Threshold phenomena versus cell heredity in the manifestation of sex-linked genes in mammals. J Embryol Exp Morphol 22(2):145-79. [PubMed: 5361553] [MGI Ref ID J:5137]
Guidry G; Landis SC. 1998. Target-dependent development of the vesicular acetylcholine transporter in rodent sweat gland innervation. Dev Biol 199(2):175-84. [PubMed: 9698438] [MGI Ref ID J:107703]
Haara O; Fujimori S; Schmidt-Ullrich R; Hartmann C; Thesleff I; Mikkola ML. 2011. Ectodysplasin and Wnt pathways are required for salivary gland branching morphogenesis. Development 138(13):2681-91. [PubMed: 21652647] [MGI Ref ID J:173573]
Hammerschmidt B; Schlake T. 2007. Localization of Shh expression by Wnt and Eda affects axial polarity and shape of hairs. Dev Biol 305(1):246-61. [PubMed: 17376426] [MGI Ref ID J:121316]
Harsan L; Jalabi W; Grucker D; Ghandour MS. 2004. New insights on neuronal alterations in jimpy mutant brain. Neurochem Res 29(5):943-52. [PubMed: 15139292] [MGI Ref ID J:106214]
Huh SH; Narhi K; Lindfors PH; Haara O; Yang L; Ornitz DM; Mikkola ML. 2013. Fgf20 governs formation of primary and secondary dermal condensations in developing hair follicles. Genes Dev 27(4):450-8. [PubMed: 23431057] [MGI Ref ID J:193958]
Isaacs K; Brown G; Moore GP. 1998. Interactions between epidermal growth factor and the Tabby mutation in skin. Exp Dermatol 7(5):273-80. [PubMed: 9832315] [MGI Ref ID J:53635]
Jamieson RV; Zhou SX; Wheatley SC; Koopman P; Tam PP. 1998. Sertoli cell differentiation and Y-chromosome activity: a developmental study of X-linked transgene activity in sex-reversed X/XSxra mouse embryos. Dev Biol 199(2):235-44. [PubMed: 9698443] [MGI Ref ID J:107693]
Jaskoll T; Zhou YM; Trump G; Melnick M. 2003. Ectodysplasin receptor-mediated signaling is essential for embryonic submandibular salivary gland development. Anat Rec A Discov Mol Cell Evol Biol 271(2):322-31. [PubMed: 12629675] [MGI Ref ID J:105968]
Johnston DS; Russell LD; Friel PJ; Griswold MD. 2001. Murine germ cells do not require functional androgen receptors to complete spermatogenesis following spermatogonial stem cell transplantation. Endocrinology 142(6):2405-8. [PubMed: 11356688] [MGI Ref ID J:109878]
Kangas AT; Evans AR; Thesleff I; Jernvall J. 2004. Nonindependence of mammalian dental characters. Nature 432(7014):211-4. [PubMed: 15538367] [MGI Ref ID J:94561]
Kapalanga J; Blecher SR. 1990. Effect of the X-linked gene Tabby (Ta) on eyelid opening and incisor eruption in neonatal mice is opposite to that of epidermal growth factor. Development 108(2):349-55. [PubMed: 2351074] [MGI Ref ID J:42661]
Knapp PE; Adjan VV; Hauser KF. 2009. Cell-specific loss of kappa-opioid receptors in oligodendrocytes of the dysmyelinating jimpy mouse. Neurosci Lett 451(2):114-8. [PubMed: 19110031] [MGI Ref ID J:146365]
Knapp PE; Dutta S; Skoff RP. 1990. Differences in levels of neuroglial cell death in jimpy male mice and carrier females. Dev Neurosci 12(3):145-52. [PubMed: 2364893] [MGI Ref ID J:116371]
Knapp PE; Skoff RP. 1993. Jimpy mutation affects astrocytes: lengthening of the cell cycle in vitro. Dev Neurosci 15(1):31-6. [PubMed: 8269866] [MGI Ref ID J:116364]
Koppinen P; Pispa J; Laurikkala J; Thesleff I; Mikkola ML. 2001. Signaling and subcellular localization of the TNF receptor Edar. Exp Cell Res 269(2):180-92. [PubMed: 11570810] [MGI Ref ID J:71957]
Kosaras B; Kirschner DA. 1990. Radial component of CNS myelin: junctional subunit structure and supramolecular assembly. J Neurocytol 19(2):187-99. [PubMed: 2113569] [MGI Ref ID J:121320]
Kristenova P; Peterka M; Lisi S; Gendrault JL; Lesot H; Peterkova R. 2002. Different morphotypes of functional dentition in the lower molar region of tabby (EDA) mice. Orthod Craniofac Res 5(4):205-14. [PubMed: 12416535] [MGI Ref ID J:103894]
LYON MF; SEARLE AG; FORD CE; OHNO S. 1964. A MOUSE TRANSLOCATION SUPPRESSING SEX-LINKED VARIEGATION. Cytogenetics 15:306-23. [PubMed: 14248461] [MGI Ref ID J:149655]
Langton AK; Herrick SE; Headon DJ. 2008. An extended epidermal response heals cutaneous wounds in the absence of a hair follicle stem cell contribution. J Invest Dermatol 128(5):1311-8. [PubMed: 18037901] [MGI Ref ID J:135502]
Laurikkala J; Mikkola M; Mustonen T; Aberg T; Koppinen P; Pispa J; Nieminen P; Galceran J; Grosschedl R; Thesleff I. 2001. TNF signaling via the ligand-receptor pair ectodysplasin and edar controls the function of epithelial signaling centers and is regulated by Wnt and activin during tooth organogenesis. Dev Biol 229(2):443-55. [PubMed: 11203701] [MGI Ref ID J:67054]
Laurikkala J; Pispa J; Jung HS; Nieminen P; Mikkola M; Wang X; Saarialho-Kere U; Galceran J; Grosschedl R; Thesleff I. 2002. Regulation of hair follicle development by the TNF signal ectodysplasin and its receptor Edar. Development 129(10):2541-53. [PubMed: 11973284] [MGI Ref ID J:75943]
Le Goascogne C; Eychenne B; Tonon MC; Lachapelle F; Baumann N; Robel P. 2000. Neurosteroid progesterone is up-regulated in the brain of jimpy and shiverer mice. Glia 29(1):14-24. [PubMed: 10594919] [MGI Ref ID J:78788]
Le Goascogne C; Sannanes N; Gouezou M; Baulieu EE; Robel P. 1993. Suppressed expression of the cytochrome P45017 alpha protein in the testicular feminized (Tfm) mouse testes. J Endocrinol 139(1):127-30. [PubMed: 8254285] [MGI Ref ID J:15718]
Lyon MF. 1963. Attempts to test the inactive-X theory of dosage compensation in mammals Genet Res 4:93-103. [MGI Ref ID J:272]
Lyon MF. 1970. Genetic activity of sex chromosomes in somatic cells of mammals. Philos Trans R Soc Lond B Biol Sci 259(828):41-52. [PubMed: 4399067] [MGI Ref ID J:5238]
Mayer TC; Green MC. 1978. Epidermis is the site of action of tabby (Ta) in the mouse. Genetics 90(1):125-31. [PubMed: 359407] [MGI Ref ID J:6041]
Melnick M; Phair RD; Lapidot SA; Jaskoll T. 2009. Salivary gland branching morphogenesis: a quantitative systems analysis of the Eda/Edar/NFkappaB paradigm. BMC Dev Biol 9:32. [PubMed: 19500387] [MGI Ref ID J:152818]
Miard S; Peterkova R; Vonesch JL; Peterka M; Ruch JV; Lesot H. 1999. Alterations in the incisor development in the Tabby mouse. Int J Dev Biol 43(6):517-29. [PubMed: 10610025] [MGI Ref ID J:104871]
Mou C; Jackson B; Schneider P; Overbeek PA; Headon DJ. 2006. Generation of the primary hair follicle pattern. Proc Natl Acad Sci U S A 103(24):9075-80. [PubMed: 16769906] [MGI Ref ID J:111052]
Mustonen T; Ilmonen M; Pummila M; Kangas AT; Laurikkala J; Jaatinen R; Pispa J; Gaide O; Schneider P; Thesleff I; Mikkola ML. 2004. Ectodysplasin A1 promotes placodal cell fate during early morphogenesis of ectodermal appendages. Development 131(20):4907-19. [PubMed: 15371307] [MGI Ref ID J:128256]
Narhi K; Jarvinen E; Birchmeier W; Taketo MM; Mikkola ML; Thesleff I. 2008. Sustained epithelial {beta}-catenin activity induces precocious hair development but disrupts hair follicle down-growth and hair shaft formation. Development 135(6):1019-28. [PubMed: 18256193] [MGI Ref ID J:131961]
Pantalacci S; Prochazka J; Martin A; Rothova M; Lambert A; Bernard L; Charles C; Viriot L; Peterkova R; Laudet V. 2008. Patterning of palatal rugae through sequential addition reveals an anterior/posterior boundary in palatal development. BMC Dev Biol 8:116. [PubMed: 19087265] [MGI Ref ID J:145173]
Pennycuik PR; Raphael KA. 1984. The tabby locus (Ta) in the mouse: its site of action in tail and body skin. Genet Res 43(1):51-63. [PubMed: 6373499] [MGI Ref ID J:7450]
Peterkova R; Kristenova P; Lesot H; Lisi S; Vonesch JL; Gendrault JL; Peterka M. 2002. Different morphotypes of the tabby (EDA) dentition in the mouse mandible result from a defect in the mesio-distal segmentation of dental epithelium. Orthod Craniofac Res 5(4):215-26. [PubMed: 12416536] [MGI Ref ID J:103893]
Peterkova R; Lesot H; Viriot L; Peterka M. 2005. The supernumerary cheek tooth in tabby/EDA mice-a reminiscence of the premolar in mouse ancestors. Arch Oral Biol 50(2):219-25. [PubMed: 15721153] [MGI Ref ID J:98533]
Pispa J; Jung HS; Jernvall J; Kettunen P; Mustonen T; Tabata MJ; Kere J; Thesleff I. 1999. Cusp patterning defect in Tabby mouse teeth and its partial rescue by FGF. Dev Biol 216(2):521-34. [PubMed: 10642790] [MGI Ref ID J:59068]
Pispa J; Pummila M; Barker PA; Thesleff I; Mikkola ML. 2008. Edar and Troy signalling pathways act redundantly to regulate initiation of hair follicle development. Hum Mol Genet 17(21):3380-91. [PubMed: 18689798] [MGI Ref ID J:140329]
Rao MS; Jaszczak E; Landis SC. 1994. Innervation of footpads of normal and mutant mice lacking sweat glands. J Comp Neurol 346(4):613-25. [PubMed: 7983247] [MGI Ref ID J:19910]
Rawlins EL; Hogan BL. 2005. Intercellular growth factor signaling and the development of mouse tracheal submucosal glands. Dev Dyn 233(4):1378-85. [PubMed: 15973734] [MGI Ref ID J:119848]
Risnes S; Peterkova R; Lesot H. 2005. Distribution and structure of dental enamel in incisors of Tabby mice. Arch Oral Biol 50(2):181-4. [PubMed: 15721148] [MGI Ref ID J:100300]
Schmidt-Ullrich R; Tobin DJ; Lenhard D; Schneider P; Paus R; Scheidereit C. 2006. NF-{kappa}B transmits Eda A1/EdaR signalling to activate Shh and cyclin D1 expression, and controls post-initiation hair placode down growth. Development 133(6):1045-57. [PubMed: 16481354] [MGI Ref ID J:106549]
Silvers WK. 1979. The Coat Colors of Mice; A Model for Mammalian Gene Action and Interaction. In: The Coat Colors of Mice. Springer-Verlag, New York. [MGI Ref ID J:78801]
Sofaer JA. 1979. Additive effects of the genes tabby and crinkled on tooth size in the mouse. Genet Res 33(2):169-74. [PubMed: 478295] [MGI Ref ID J:151073]
Sofaer JA. 1969. Aspects of the tabby-crinkled-downless syndrome. I. The development of tabby teeth. J Embryol Exp Morphol 22(2):181-205. [PubMed: 5361554] [MGI Ref ID J:5138]
Sofaer JA. 1969. Aspects of the tabby-crinkled-downless syndrome. II. Observations on the reaction to changes of genetic background. J Embryol Exp Morphol 22(2):207-27. [PubMed: 5361555] [MGI Ref ID J:5139]
Sofaer JA. 1974. Differences between tabby and downless mouse epidermis and dermis in culture. Genet Res 23(2):219-25. [PubMed: 4420168] [MGI Ref ID J:5489]
Sofaer JA; MacLean CJ. 1970. Dominance in threshold characters. A comparison of two tabby alleles in the mouse. Genetics 64(2):273-80. [PubMed: 5470481] [MGI Ref ID J:5176]
Srivastava AK; Durmowicz MC; Hartung AJ; Hudson J; Ouzts LV; Donovan DM; Cui CY; Schlessinger D. 2001. Ectodysplasin-A1 is sufficient to rescue both hair growth and sweat glands in Tabby mice. Hum Mol Genet 10(26):2973-81. [PubMed: 11751679] [MGI Ref ID J:73715]
Srivastava AK; Pispa J; Hartung AJ; Du Y; Ezer S; Jenks T; Shimada T; Pekkanen M; Mikkola ML; Ko MS; Thesleff I; Kere J; Schlessinger D. 1997. The Tabby phenotype is caused by mutation in a mouse homologue of the EDA gene that reveals novel mouse and human exons and encodes a protein (ectodysplasin-A) with collagenous domains. Proc Natl Acad Sci U S A 94(24):13069-74. [PubMed: 9371801] [MGI Ref ID J:44605]
Sundberg JP (ed.). 1994. Handbook of Mouse Mutations with Skin and Hair Abnormalities: Animal Models and Biomedical Tools. In: Handbook of Mouse Mutations with Skin and Hair Abnormalities: Animal Models and Biomedical Tools. CRC Press, Boca Raton. [MGI Ref ID J:30359]
Toda I; Sullivan BD; Wickham LA; Sullivan DA. 1999. Gender- and androgen-related influence on the expression of proto-oncogene and apoptotic factor mRNAs in lacrimal glands of autoimmune and non-autoimmune mice. J Steroid Biochem Mol Biol 71(1-2):49-61. [PubMed: 10619357] [MGI Ref ID J:58967]
Tucker AS; Headon DJ; Courtney JM; Overbeek P; Sharpe PT. 2004. The activation level of the TNF family receptor, Edar, determines cusp number and tooth number during tooth development. Dev Biol 268(1):185-94. [PubMed: 15031115] [MGI Ref ID J:92196]
Turtzo LC; Siegel C; McCullough LD. 2011. X chromosome dosage and the response to cerebral ischemia. J Neurosci 31(37):13255-9. [PubMed: 21917808] [MGI Ref ID J:191548]
Vargas GA; Fantino E; George-Nascimento C; Gargus JJ; Haigler HT. 1996. Reduced epidermal growth factor receptor expression in hypohidrotic ectodermal dysplasia and Tabby mice. J Clin Invest 97(11):2426-32. [PubMed: 8647934] [MGI Ref ID J:33361]
Vielkind U; Hardy MH. 1996. Changing patterns of cell adhesion molecules during mouse pelage hair follicle development. 2. Follicle morphogenesis in the hair mutants, Tabby and downy. Acta Anat (Basel) 157(3):183-94. [PubMed: 9226037] [MGI Ref ID J:41386]
Voutilainen M; Lindfors PH; Lefebvre S; Ahtiainen L; Fliniaux I; Rysti E; Murtoniemi M; Schneider P; Schmidt-Ullrich R; Mikkola ML. 2012. Ectodysplasin regulates hormone-independent mammary ductal morphogenesis via NF-kappaB. Proc Natl Acad Sci U S A 109(15):5744-9. [PubMed: 22451941] [MGI Ref ID J:183539]
Wells KL; Mou C; Headon DJ; Tucker AS. 2011. Defects and rescue of the minor salivary glands in Eda pathway mutants. Dev Biol 349(2):137-46. [PubMed: 20969842] [MGI Ref ID J:168036]
Wells KL; Mou C; Headon DJ; Tucker AS. 2010. Recombinant EDA or Sonic Hedgehog rescue the branching defect in Ectodysplasin A pathway mutant salivary glands in vitro. Dev Dyn :. [PubMed: 20803597] [MGI Ref ID J:164212]
Yamago G; Takata Y; Furuta I; Urase K; Momoi T; Huh N. 2001. Suppression of hair follicle development inhibits induction of sonic hedgehog, patched, and patched-2 in hair germs in mice. Arch Dermatol Res 293(9):435-41. [PubMed: 11758785] [MGI Ref ID J:116953]
Zhang Y; Tomann P; Andl T; Gallant NM; Huelsken J; Jerchow B; Birchmeier W; Paus R; Piccolo S; Mikkola ML; Morrisey EE; Overbeek PA; Scheidereit C; Millar SE; Schmidt-Ullrich R. 2009. Reciprocal requirements for EDA/EDAR/NF-kappaB and Wnt/beta-catenin signaling pathways in hair follicle induction. Dev Cell 17(1):49-61. [PubMed: 19619491] [MGI Ref ID J:151982]
Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Room Number FGB29
Colony Maintenance
Mating System Outcross-Intercross (Female x Male) 01-MAR-06 TJL Breeding Scheme: hemizygote x F1 then (X/O) wild type sibling x hemizygote
TJL Breeding Summary: genotypes of breeders are EdaTa/O x B6CBCaF1Aw-J/A in the first generation then +/O x EdaTa/Y in the second generation. Viable offspring produced from the first generation breeder pair are EdaTa/+ females, +/O females, and EdaTa/Y males.
Viable offspring produced from the second generation breeder pair are EdaTa/+ females, normal +/Y males, and EdaTa/O females.Diet Information LabDiet® 5K52/5K67
Pricing and Purchasing
Pricing, Supply Level & Notes, Controls
| Pricing for USA, Canada and Mexico shipping destinations |
|
Live Mice
Price per mouse (US dollars $) Gender Genotypes Provided Individual Mouse $232.00 Female or Male Hemizygous for EdaTa $177.00 Female Hemizygous for X Individual Mouse $177.00 Female Heterozygous for EdaTa
Price per Pair (US dollars $) Pair Genotype $342.00 Hemizygous for EdaTa x B6CBACaF1/J-Aw-J/A (001201) $409.00 Hemizygous for X x Hemizygous for EdaTa Standard Supply
Repository-Live. Repository-Live represents an exclusive set of over 1500 unique mouse models maintained at The Jackson Laboratory to support a vast array of research areas. The breeding colonies for Repository Strains provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. Repository-live orders are treated as custom orders. Within 2 business days, we respond to each availability inquiry or order with various delivery options. Repository Strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping.
| Pricing for International shipping destinations |
|
Live Mice
Price per mouse (US dollars $) Gender Genotypes Provided Individual Mouse $301.60 Female or Male Hemizygous for EdaTa $230.10 Female Hemizygous for X Individual Mouse $230.10 Female Heterozygous for EdaTa
Price per Pair (US dollars $) Pair Genotype $444.60 Hemizygous for EdaTa x B6CBACaF1/J-Aw-J/A (001201) $531.70 Hemizygous for X x Hemizygous for EdaTa Standard Supply
Repository-Live. Repository-Live represents an exclusive set of over 1500 unique mouse models maintained at The Jackson Laboratory to support a vast array of research areas. The breeding colonies for Repository Strains provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. Repository-live orders are treated as custom orders. Within 2 business days, we respond to each availability inquiry or order with various delivery options. Repository Strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping.
|
|
|
Standard Supply
Repository-Live. Repository-Live represents an exclusive set of over 1500 unique mouse models maintained at The Jackson Laboratory to support a vast array of research areas. The breeding colonies for Repository Strains provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. Repository-live orders are treated as custom orders. Within 2 business days, we respond to each availability inquiry or order with various delivery options. Repository Strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping.
General Supply Notes
- View the complete collection of spontaneous mutants in the Mouse Mutant Resource.
- Genomic DNA is available for this strain from the Mouse DNA Resource.
Control Information
| Control | ||
|---|---|---|
| +/+, EdaTa/+ or +/Y from the colony | ||
| 001201 B6CBACaF1/J-Aw-J/A | (approximate) | |
| Considerations for Choosing Controls | ||
| Control Pricing Information for Genetically Engineered Mutant Strains. | ||
Payment Terms and Conditions
Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.
See Terms of Use tab for General Terms and Conditions
The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering Information
JAX® Mice
Surgical and Preconditioning Services
JAX® Services
Customer Services and Support
Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
Technical Support Email Form
Terms of Use
Terms of Use
General Terms and Conditions
Contact information
General inquiries regarding Terms of UseContracts Administration
| phone: | 207-288-6470 |
| fax: | 207-288-6655 |
JAX® Mice, Products & Services Conditions of Use
"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.No Warranty
MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.
In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.
No Liability
In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.
MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.
The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.
Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.