Former Names BXD-20/TyJ (Changed: 15-DEC-04 ) Type Recombinant Inbred (RI); Additional information on Recombinant Inbred Mice. Visit our online Nomenclature tutorial. Mating System Sibling x Sibling (Female x Male) 01-MAR-06 Species laboratory mouse RI progenitor C57BL/6J DBA/2J H2 Haplotype b Generation F48N5F75+10p+3 (15-SEP-12)
Related Genotype: a/a Tyrp1+/Tyrp1+ Myo5a+/Myo5a+
The BXD RI strains are used to study the genetics of behavioral phenotypes including alcohol and drug addiction, stress, and locomotor activity.The BXD set of RI strains also are used in the genetic analysis of numerous complex or potentially complex physiologic phenotypes including differences in organ weight and bone mineral density. The strain distribution pattern (SDP) for BXD RI strains is available through the Mouse Genome Informatics Recombinant Inbred Strain Distribution Patterns.
The BXD set of RI strains was developed in the laboratory of Benjamin Taylor and was transferred to The Jackson Laboratory from Dr. Taylor's research colony upon his retirement. Of 42 BXD RI strains originally derived from the C57BL/6J (Stock No. 000664) and DBA/2J (Stock No. 000671), a number have become extinct over the years. The other BXD RI strains now being distributed are listed under "Related Recombinant Inbred Strains."
In 1982/83 after BXD-20/Ty had been intercrossed approximately 48 times (uncertain of exact date and filial generation number) one F20 BXD20/Ty male was outcrossed once to a single C57BL/6J female. The N1 offspring from this cross were then backcrossed to their sire, and this process was repeated 4 times. In total the outcross to C57BL/6J was followed by 4 consecutive backcrosses to the same F20 BXD-2/Ty male. The line was then intercrossed and after 20 additional generations of inbreeding efforts began to cryopreserve the strain. The generation numbers of the cryopreserved mice range from F20N5F19W through F20N5F34).
000036 BXD1/TyJ 007143 BXD100/RwwJ 007144 BXD101/RwwJ 007145 BXD102/RwwJ 000012 BXD11/TyJ 000045 BXD12/TyJ 000040 BXD13/TyJ 000329 BXD14/TyJ 000095 BXD15/TyJ 000013 BXD16/TyJ 000015 BXD18/TyJ 000010 BXD19/TyJ 000075 BXD2/TyJ 000077 BXD21/TyJ 000043 BXD22/TyJ 005243 BXD24/TyJ 000031 BXD24/TyJ-Cep290rd16/J 000081 BXD25/TyJ 000041 BXD27/TyJ 000047 BXD28/TyJ 000029 BXD29-Tlr4lps-2J/J 010981 BXD29/Ty 000083 BXD31/TyJ 000078 BXD32/TyJ 003222 BXD33/TyJ 003223 BXD34/TyJ 003225 BXD36/TyJ 003227 BXD38/TyJ 003228 BXD39/TyJ 003229 BXD40/TyJ 003230 BXD42/TyJ 007093 BXD43/RwwJ 007094 BXD44/RwwJ 007096 BXD45/RwwJ 007097 BXD48/RwwJ 007139 BXD48a/RwwJ 007098 BXD49/RwwJ 000037 BXD5/TyJ 007099 BXD50/RwwJ 007100 BXD51/RwwJ 017749 BXD53/2RwwJ 007103 BXD55/RwwJ 007104 BXD56/RwwJ 000007 BXD6/TyJ 007105 BXD60/RwwJ 007106 BXD61/RwwJ 007107 BXD62/RwwJ 007108 BXD63/RwwJ 007109 BXD64/RwwJ 007109 BXD64/RwwJ 007110 BXD65/RwwJ 007140 BXD65a/RwwJ 009677 BXD65b/RwwJ 007111 BXD66/RwwJ 007112 BXD67/RwwJ 007113 BXD68/RwwJ 007114 BXD69/RwwJ 007115 BXD70/RwwJ 007116 BXD71/RwwJ 007117 BXD73/RwwJ 007124 BXD73a/RwwJ 007146 BXD73b/RwwJ 007118 BXD74/RwwJ 007119 BXD75/RwwJ 007121 BXD77/RwwJ 007123 BXD79/RwwJ 000084 BXD8/TyJ 007125 BXD81/RwwJ 007126 BXD83/RwwJ 007127 BXD84/RwwJ 007128 BXD85/RwwJ 007129 BXD86/RwwJ 007130 BXD87/RwwJ 017750 BXD88/2RwwJ 007132 BXD89/RwwJ 000105 BXD9/TyJ 007133 BXD90/RwwJ 017751 BXD91/2RwwJ 007138 BXD95/RwwJ 007141 BXD98/RwwJView BXD Strains (80 strains)
View Phenotypic DataPhenotypic DataView Research Applications
Alexander RC; Wright R; Freed W. 1996. Quantitative trait loci contributing to phencyclidine-induced and amphetamine-induced locomotor behavior in inbred mice. Neuropsychopharmacology 15(5):484-90. [PubMed: 8914121] [MGI Ref ID J:36714]
Belknap JK; Crabbe JC; Plomin R; McClearn GE; Sampson KE; O'Toole LA; Gora-Maslak G. 1992. Single-locus control of saccharin intake in BXD/Ty recombinant inbred (RI) mice: some methodological implications for RI strain analysis. Behav Genet 22(1):81-100. [PubMed: 1590732] [MGI Ref ID J:1952]
Belknap JK; Metten P; Helms ML; O'Toole LA; Angeli-Gade S; Crabbe JC; Phillips TJ. 1993. Quantitative trait loci (QTL) applications to substances of abuse: physical dependence studies with nitrous oxide and ethanol in BXD mice. Behav Genet 23(2):213-22. [PubMed: 8512534] [MGI Ref ID J:11831]
Belknap JK; Mogil JS; Helms ML; Richards SP; O'Toole LA; Bergeson SE; Buck KJ. 1995. Localization to chromosome 10 of a locus influencing morphine analgesia in crosses derived from C57BL/6 and DBA/2 strains. Life Sci 57(10):PL117-24. [PubMed: 7643715] [MGI Ref ID J:28263]
Belknap JK; Phillips TJ; O'Toole LA. 1992. Quantitative trait loci associated with brain weight in the BXD/Ty recombinant inbred mouse strains. Brain Res Bull 29(3-4):337-44. [PubMed: 1393606] [MGI Ref ID J:2827]
Cabib S; Oliverio A; Ventura R; Lucchese F; Puglisi-Allegra S. 1997. Brain dopamine receptor plasticity: testing a diathesis-stress hypothesis in an animal model. Psychopharmacology (Berl) 132(2):153-60. [PubMed: 9266612] [MGI Ref ID J:68169]
Crabbe JC. 1998. Provisional mapping of quantitative trait loci for chronic ethanol withdrawal severity in BXD recombinant inbred mice. J Pharmacol Exp Ther 286(1):263-71. [PubMed: 9655868] [MGI Ref ID J:49185]
Crabbe JC; Belknap JK; Mitchell SR; Crawshaw LI. 1994. Quantitative trait loci mapping of genes that influence the sensitivity and tolerance to ethanol-induced hypothermia in BXD recombinant inbred mice. J Pharmacol Exp Ther 269(1):184-92. [PubMed: 8169823] [MGI Ref ID J:18566]
Cunningham CL. 1995. Localization of genes influencing ethanol-induced conditioned place preference and locomotor activity in BXD recombinant inbred mice. Psychopharmacology (Berl) 120(1):28-41. [PubMed: 7480533] [MGI Ref ID J:28135]
Gora-Maslak G; McClearn GE; Crabbe JC; Phillips TJ; Belknap JK; Plomin R. 1991. Use of recombinant inbred strains to identify quantitative trait loci in psychopharmacology. Psychopharmacology (Berl) 104(4):413-24. [PubMed: 1780413] [MGI Ref ID J:39738]
Grisel JE; Belknap JK; O'Toole LA; Helms ML; Wenger CD; Crabbe JC. 1997. Quantitative trait loci affecting methamphetamine responses in BXD recombinant inbred mouse strains. J Neurosci 17(2):745-54. [PubMed: 8987796] [MGI Ref ID J:37546]
Hofstetter JR; Mayeda AR; Possidente B; Nurnberger JI. 1995. Quantitative trait loci (QTL) for circadian rhythms of locomotor activity in mice. Behav Genet 25(6):545-56. [PubMed: 8540893] [MGI Ref ID J:29803]
Hofstetter JR; Possidente B; Mayeda AR. 1999. Provisional QTL for circadian period of wheel running in laboratory mice: quantitative genetics of period in RI mice. Chronobiol Int 16(3):269-79. [PubMed: 10373097] [MGI Ref ID J:55774]
Klein RF; Mitchell SR; Phillips TJ; Belknap JK; Orwoll ES. 1998. Quantitative trait loci affecting peak bone mineral density in mice. J Bone Miner Res 13(11):1648-56. [PubMed: 9797472] [MGI Ref ID J:50828]
Miner LL; Marley RJ. 1995. Chromosomal mapping of loci influencing sensitivity to cocaine-induced seizures in BXD recombinant inbred strains of mice. Psychopharmacology (Berl) 117(1):62-6. [PubMed: 7724703] [MGI Ref ID J:23071]
Mogil JS; Richards SP; O'Toole LA; Helms ML; Mitchell SR; Kest B; Belknap JK. 1997. Identification of a sex-specific quantitative trait locus mediating nonopioid stress-induced analgesia in female mice. J Neurosci 17(20):7995-8002. [PubMed: 9315917] [MGI Ref ID J:43467]
Phillips TJ; Huson M; Gwiazdon C; Burkhart-Kasch S; Shen EH. 1995. Effects of acute and repeated ethanol exposures on the locomotor activity of BXD recombinant inbred mice. Alcohol Clin Exp Res 19(2):269-78. [PubMed: 7625557] [MGI Ref ID J:25695]
Phillips TJ; Huson MG; McKinnon CS. 1998. Localization of genes mediating acute and sensitized locomotor responses to cocaine in BXD/Ty recombinant inbred mice. J Neurosci 18(8):3023-34. [PubMed: 9526019] [MGI Ref ID J:46922]
Plomin R; McClearn GE; Gora-Maslak G; Neiderhiser JM. 1991. Use of recombinant inbred strains to detect quantitative trait loci associated with behavior. Behav Genet 21(2):99-116. [PubMed: 2049054] [MGI Ref ID J:11248]
Quock RM; Mueller JL; Vaughn LK; Belknap JK. 1996. Nitrous oxide antinociception in BXD recombinant inbred mouse strains and identification of quantitative trait loci. Brain Res 725(1):23-9. [PubMed: 8828582] [MGI Ref ID J:34065]
Roberts AJ; Phillips TJ; Belknap JK; Finn DA; Keith LD. 1995. Genetic analysis of the corticosterone response to ethanol in BXD recombinant inbred mice. Behav Neurosci 109(6):1199-208. [PubMed: 8748968] [MGI Ref ID J:31087]
Rodriguez LA; Plomin R; Blizard DA; Jones BC; McClearn GE. 1995. Alcohol acceptance, preference, and sensitivity in mice. II. Quantitative trait loci mapping analysis using BXD recombinant inbred strains. Alcohol Clin Exp Res 19(2):367-73. [PubMed: 7625571] [MGI Ref ID J:25698]
Tarricone BJ; Hwang WG; Hingtgen JN; Mitchell SR; Belknap JK; Nurnberger JI. 1995. Identification of a locus on mouse chromosome 17 associated with high-affinity choline uptake using BXD recombinant inbred mice and quantitative trait loci analysis. Genomics 27(1):161-4. [PubMed: 7665164] [MGI Ref ID J:25620]
Zidek V; Musilova A; Pintir J; Simakova M; Pravenec M. 1998. Genetic dissection of testicular weight in the mouse with the BXD recombinant inbred strains. Mamm Genome 9(7):503-5. [PubMed: 9657844] [MGI Ref ID J:48698]
Animal Health ReportsRoom Number FGB27
Mating System Sibling x Sibling (Female x Male) 01-MAR-06
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Price per mouse (US dollars $) Gender Individual Mouse $143.00 Female or Male
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