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Strain Name:

C57BL/6J Aw-J-EdaTa-6J/J

Stock Number:

000338

Availability:

Repository-Cryopreserved

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General Terms and Conditions

Former Name      C57BL/6J-Aw-J-EdaTa-6J/J    (Changed: 18-FEB-05 )
Genes & Alleles   Aw-J;   Eda;   EdaTa-6J;   a;

Product Information

Strain Details

Type JAX® GEMM® Strain - Mutant Strain
Additional information on JAX® GEMM® Strains.
Type JAX® GEMM® Strain - Spontaneous Mutation
Mating SystemHeterozygote x +/+ sibling         (Female x Male)
Specieslaboratory mouse
GenerationN3F16p

Appearance
white-bellied agouti and mosaic striped coat
Related Genotype: Aw-J/Aw-J EdaTa-6J/+ females

white-bellied agouti, no striping in coat
Related Genotype: Aw-J/Aw-J +/+ females or Aw-J/Aw-J +/Y males

tabby (yellow coat, no hair on ears and tail, bald patch behind ears, no guard hairs)
Related Genotype: Aw-J/Aw-J EdaTa-6J /Y males

Related Disease (OMIM) Terms

Ectodermal Dysplasia 1; ED1
Mammalian Phenotype Terms assigned by genotype

EdaTa-6J/Y

        C57BL/6J Aw-J-EdaTa-6J/J
  • endocrine/exocrine gland phenotype
  • absent meibomian glands (MGI Ref ID J:86628)
  • absent palmar eccrine glands (MGI Ref ID J:86628)
  • absent preputial gland (MGI Ref ID J:86628)
    • absent preputial glands
  • skin/coat/nails phenotype
  • abnormal hair types (MGI Ref ID J:86628)
    • males have more medium-length hair, however because they lack guard and zigzag hairs the overall number of hair follicles is the same
    • absent guard hair (MGI Ref ID J:86628)
    • absent zigzag hairs (MGI Ref ID J:86628)
  • abnormal skin morphology (MGI Ref ID J:86628)
    • do not exhibit skin ridges on the tail as in wild type
    • absent meibomian glands (MGI Ref ID J:86628)
    • absent preputial gland (MGI Ref ID J:86628)
      • absent preputial glands
  • localized bare skin (MGI Ref ID J:86628)
    • mutants have a bald patch behind the ear and absent hair on the tail
  • short hair (MGI Ref ID J:86628)
    • hair coat is short and thin
  • yellow coat color (MGI Ref ID J:86628)
    • hair coat is yellowish
  • growth/size phenotype
  • decreased body weight (MGI Ref ID J:86628)
    • at 5 months of age, weight is 77% that of wild type
  • craniofacial phenotype
  • decreased molar number (MGI Ref ID J:86628)
    • mutants have 2-3 molars compared to 3 in wild type
  • vision/eye phenotype
  • abnormal eye morphology (MGI Ref ID J:99510)
    • several males have abundant mucus in the eye at 23 weeks of age
    • abnormal cornea morphology (MGI Ref ID J:99510)
      • more than 80% develop progressive corneal lesions beginning at 4-9 weeks of age such as neovascularization, keratitis, ulceration, and keratinization
      • abnormal corneal epithelium morphology (MGI Ref ID J:99510)
        • mutants exhibit a progressive corneal epithelia defect starting at 8-9 weeks of age and develop epithelial edema and acanthosis
      • corneal opacity (MGI Ref ID J:99510)
        • 9 of 15 males have grossly visible white or white and red central, elevated corneal opacities at around 23 weeks of age
      • corneal vascularization (MGI Ref ID J:99510)
        • corneal neovascularization begins at 8-9 weeks of age and eventually leads to vision loss
      • increased incidence of corneal inflammation (MGI Ref ID J:99510)
        • increased susceptibility to corneal inflammation is seen from 8 weeks of age in males housed in convention housing but not in mice in a pathogen-free facility
    • abnormal eyelid morphology (MGI Ref ID J:99510)
      • thickened eyelid margins and loss of hair along the eyelid margins
      • absent meibomian glands (MGI Ref ID J:86628)
      • blepharitis (MGI Ref ID J:99510)
      • narrow eye opening (MGI Ref ID J:99510)
        • narrowed palpebral fissures
    • conjunctivitis (MGI Ref ID J:99510)
  • blindness (MGI Ref ID J:99510)
    • develop severe blinding lesions in the cornea over time
    • blindness by 9 months of age
  • eye inflammation (MGI Ref ID J:99510)
    • more than 80% show ocular surface inflammation (limbitis, conjunctivitis, blepharitis)
    • conjunctivitis (MGI Ref ID J:99510)
  • immune system phenotype
  • eye inflammation (MGI Ref ID J:99510)
    • more than 80% show ocular surface inflammation (limbitis, conjunctivitis, blepharitis)
    • blepharitis (MGI Ref ID J:99510)
    • conjunctivitis (MGI Ref ID J:99510)
    • increased incidence of corneal inflammation (MGI Ref ID J:99510)
      • increased susceptibility to corneal inflammation is seen from 8 weeks of age in males housed in convention housing but not in mice in a pathogen-free facility
  • limbs/digits/tail phenotype
  • absent palmar eccrine glands (MGI Ref ID J:86628)
  • pigmentation phenotype
  • yellow coat color (MGI Ref ID J:86628)
    • hair coat is yellowish
  • reproductive system phenotype
  • absent preputial gland (MGI Ref ID J:86628)
    • absent preputial glands

Gene & Allele Details

Allele Symbol Aw-J
Allele Name white bellied agouti Jackson
Common Name(s) AWJ;
Strain of OriginC57BL/6J
Gene Symbol and Name a, nonagouti
Chromosome 2
Gene Common Name(s) AGSW; AGTI; AGTIL; ASP; As; MGC126092; MGC126093; SHEP9; agouti; agouti signal protein; agouti suppressor;
 
Allele Symbol EdaTa-6J
Allele Name tabby 6 Jackson
Common Name(s) Ta6J; Tabby;
Strain of OriginC57BL/6J-tp3J/J
Gene Symbol and Name Eda, ectodysplasin-A
Chromosome X
Gene Common Name(s) ED1; ED1-A1; ED1-A2; EDA1; EDA2; Eda-A1; Eda-A2; HED; RGD1563178; Ta; XHED; XLHED; tabby;
Molecular Note This allele is defined by a base pair deletion (at position 1049) resulting in a frameshift mutation. [MGI Ref ID J:42614]

Control Information

  Control
   Wild-type from the colony
 
  Considerations for Choosing Controls

Genotyping Protocols

Aw-J

Related Strains

View Strains carrying   Aw-J     (31 strains)

Strains carrying   EdaTa-6J allele
002016   B6(Cg)-Aw-J EdaTa-6J Chr YB6-Sxr/EiJ
000552   B6-Aw-J-EdaTa-6J.Cg-Sxr
001730   B6-Aw-J-EdaTa-6J.Cg-Sxrb Hya-/J
001809   B6-Aw-J.Cg-EdaTa-6J +/+ ArTfm/J
View Strains carrying   EdaTa-6J     (4 strains)

Strains carrying other alleles of Eda
000841   B6-Aw-J.CBy-EdaTa-By/J
000314   B6CBACa Aw-J/A-EdaTa/J-XO
000287   B6CBACa Aw-J/A-Plp1jp EdaTa/J
001232   C3H/HeJ-EdaTa-5J/J
000569   C57BL/6J-Aw-J-EdaTa +/+ ArTfm/J
003112   STOCK EdaTa-5J/J
000583   STOCK T(X;16)16H +/+ EdaTa
View Strains carrying other alleles of Eda     (7 strains)

Strains carrying other alleles of a
003301   (C57BL/6J x C3H-Eya1bor)F1/J
000251   AEJ.Cg-ae +/a Gdf5bp-H/J
000202   AEJ/Gn-bd/J
000199   AEJ/GnLeJ
000427   B10.CE-H13b Aw/(30NX)SnJ
000420   B10.LP-H13b Aw/Sn
000477   B10.PA-Pldnpa H3e at/SnJ
000419   B10.UW-H3b we Pax1un at/SnJ
003879   B10;TFLe-a/a T tf/+ tf/J
001538   B6 x B6C3Sn a/A-T(1;9)27H/J
000916   B6 x B6C3Sn a/A-T(5;12)31H/J
000602   B6 x B6C3Sn a/A-T(8;16)17H/J
002083   B6 x B6EiC3 a/A-T(7;16)235Dn/J
000507   B6 x B6EiC3 a/A-Otcspf/J
000618   B6 x FSB/GnEi a/a Ctslfs/J
000577   B6 x STOCK a Oca2p Hps5ru2 Ednrbs/J
000601   B6 x STOCK a/a T(7;18)50H/J
000592   B6 x STOCK T(2;4)13H a/J
000769   B6.C/(HZ18)By-at-44J/J
000001   B6.C3 A/a Mgrn1md/J
000203   B6.C3-Aiy/a/J
000017   B6.C3Fe-Avy/J
000628   B6.CE-A Amy1b Amy2b/J
005505   B6.Cg-Ay Slc7a11sut/LmLlp
000021   B6.Cg-Ay/J
001572   B6.Cg-am-J/J
004200   B6;CBACa Aw-J/A-Npr2cn-2J/J
000785   B6;D2-a Es1e/J
000604   B6C3 a/A-T(10;13)199H +/+ Lystbg-J/J or Lystbg-2J/J
002807   B6C3Fe a/a-Meox2fla/J
000224   B6C3Fe a/a-Scyl1mdf/J
001037   B6C3Fe a/a-Agtpbp1pcd/J
000221   B6C3Fe a/a-Alx4lst-J/J
002062   B6C3Fe a/a-Atp7aMo-8J/J
001756   B6C3Fe a/a-Cacng2stg/J
001815   B6C3Fe a/a-Col1a2oim/J
000231   B6C3Fe a/a-Csf1op/J
000209   B6C3Fe a/a-Dh/J
000211   B6C3Fe a/a-Dstdt-J/J
000210   B6C3Fe a/a-Edardl-J/J
000207   B6C3Fe a/a-Edaraddcr/J
000182   B6C3Fe a/a-Eef1a2wst/J
001278   B6C3Fe a/a-Glra1spd/J
000241   B6C3Fe a/a-Glrbspa/J
002875   B6C3Fe a/a-Hoxd13spdh/J
000304   B6C3Fe a/a-Krt71Ca Scn8amed-J/J
000226   B6C3Fe a/a-Largemyd/J
000636   B6C3Fe a/a-Lmx1adr-J/J
001280   B6C3Fe a/a-Lse/J
001573   B6C3Fe a/a-MitfMi/J
001035   B6C3Fe a/a-Napahyh/J
000181   B6C3Fe a/a-Otogtwt/J
000278   B6C3Fe a/a-Papss2bm Hps1ep Hps6ru/J
000205   B6C3Fe a/a-Papss2bm/J
002078   B6C3Fe a/a-Pcdh15av-2J/J
000246   B6C3Fe a/a-Pitpnavb/J
001430   B6C3Fe a/a-Ptch1mes/J
000506   B6C3Fe a/a-Qkqk/J
000235   B6C3Fe a/a-Relnrl/J
000237   B6C3Fe a/a-Rorasg/J
000290   B6C3Fe a/a-Sox10Dom/J
000230   B6C3Fe a/a-Tcirg1oc/J
003612   B6C3Fe a/a-Trak1hyrt/J
001512   B6C3Fe a/a-Ttnmdm/J
001607   B6C3Fe a/a-Unc5crcm/J
000005   B6C3Fe a/a-Wc/J
000243   B6C3Fe a/a-Wnt1sw/J
000248   B6C3Fe a/a-Xpl/J
001750   B6C3Fe a/a-XsJ/J
000624   B6C3Fe a/a-anx/J
003020   B6C3Fe a/a-dep/J
002018   B6C3Fe a/a-din/J
002339   B6C3Fe a/a-nma/J
000240   B6C3Fe a/a-soc/J
000063   B6C3Fe a/a-sy/J
001055   B6C3Fe a/a-tip/J
000245   B6C3Fe a/a-tn/J
000065   B6C3Fe a/a-we Pax1un at/J
000296   B6C3Fe-a/a Hoxa13Hd Mcoln3Va-J/J
000019   B6C3Fe-a/a-Itpr1opt/J
001022   B6C3FeF1/J a/a
001752   B6CBCa Aw-J/A-T(7;15)9H/J
000971   B6EiC3 a/A-Och/J
000551   B6EiC3 a/A-Tbx15de-H/J
006450   B6EiC3 a/A-Vss/J
000557   B6EiC3-+ a/LnpUl A/J
000504   B6EiC3Sn a/A-Cacnb4lh/J
000553   B6EiC3Sn a/A-Egfrwa2 Wnt3avt/J
000503   B6EiC3Sn a/A-Gy/J
001811   B6EiC3Sn a/A-Otcspf-ash/J
002343   B6EiC3Sn a/A-Otcspf/J
000391   B6EiC3Sn a/A-Pax6Sey-Dey/J
001924   B6EiC3Sn a/A-Ts(1716)65Dn
001923   B6EiC3Sn a/A-Ts(417)2Lws Tim/J
000200   C3FeB6 A/Aw-J-Ankank/J
000638   C3FeB6 A/Aw-J-Spnb4qv-J/J
000225   C3FeLe.B6 a/a-Ptpn6me/J
000198   C3FeLe.B6-a/J
000291   C3FeLe.Cg-a/a Hm KitlSl Krt71Ca-J/J
001272   C3H/HeSnJ-Ahvy/J
000099   C3HeB/FeJ-Avy/J
001886   C3HeB/FeJLe a/a-gnd/J
000584   C57BL/6J-+ T(1;2)5Ca/a +/J
000258   C57BL/6J-Ai/a/J
000774   C57BL/6J-Asy/a/J
000055   C57BL/6J-at-33J/J
000070   C57BL/6J-atd/J
000284   CWD/LeJ
000670   DBA/1J
000671   DBA/2J
001057   HPT/LeJ
000260   JGBF/LeJ
002468   KK.Cg-Ay/J
000262   LS/LeJ
000283   LT.CAST-A/J
000265   MY/HuLeJ
000308   SSL/LeJ
001759   STOCK A Tyrc Sha/J
001427   STOCK Aw us/J
000994   STOCK a Myo5ad Mregdsu/J
000064   STOCK a Tyrp1b Sisi/J
002238   STOCK a Tyrp1b shmy/J
001433   STOCK a skt/J
000579   STOCK a tp/J
000319   STOCK a us/J
002648   STOCK a/a Cln6nclf/J
000317   STOCK a/a Egfrwa2/J
000302   STOCK a/a MitfMi-wh +/+ Itpr1opt/J
000286   STOCK a/a Myo5ad fd/+ +/J
000206   STOCK a/a Tyrc-h/J
001432   STOCK a/a Tyrp1b sks/Tyrp1b +/J
000281   STOCK a/a ma ft/ma ft/J
000312   STOCK stb + a/+ Fignfi a/J
000596   STOCK T(2;11)30H/+ x AEJ-a Gdf5bp-H/J or A/J-a Gdf5bp-J/J
000970   STOCK T(2;16)28H A/T(2;16)28H a/J
000590   STOCK T(2;4)1Sn a/J
000594   STOCK T(2;8)26H a/T(2;8)26H a Tyrp1+/Tyrp1b/J
000623   TR/DiEiJ
View Strains carrying other alleles of a     (138 strains)

Additional Web Information

JAX® NOTES, January 1990, 440. Tabby Stocks Available from The Jackson Laboratory.

Research Applications

This mouse can be used to support research in many areas including:

EdaTa-6J related

Dermatology Research
Color and White Spotting Defects
Skin and Hair Texture Defects

Developmental Biology Research
Eye Defects

Mouse/Human Gene Homologs
hypohidrotic ectodermal dysplasia

Sensorineural Research
Eye Defects

References

Additional References

Price and Supply Information

Strain Name: C57BL/6J Aw-J-EdaTa-6J/J
Stock Number: 000338

Price Details

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Supply Details

Standard SupplyRepository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information.
Supply Notes Cryorecovery - Standard.
The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two males and two females (two pairs) will be provided, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the delivery time to approximately 25 weeks. At least one member of each pair will be of known genotype and will carry the mutation if it is a mutant strain. Please note that pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Price represents a repository maintenance fee, which includes the cost of recovery of the strain from the cryopreservation resource and the periodic replacement of the frozen embryos used for recovery.

Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
One to two pairs will be recovered to establish a Dedicated Supply of mice. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services: Tel: 1-800-422-6423 or 1-207-288-5845; Email: jaxservices@jax.org.
This strain is included in the Mouse Mutant Resource collection.
Genomic DNA is available for this strain from the Mouse DNA Resource.

LicensingSee General Terms and Conditions below  
Control InformationView Control Information in Strain Details.

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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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