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- Description
- Phenotype
- Genes & alleles
- Genotyping
- Health & husbandry
- References
- Purchasing information
- Terms of Use
Description
The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.
Strain Information
Former Names C57BL/6J-Aw-J-EdaTa-6J/J (Changed: 18-FEB-05 ) Type Mutant Strain; Spontaneous Mutation; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Mating System Heterozygote x +/+ sibling (Female x Male) 01-MAR-06 Species laboratory mouse Generation N3F16p Appearance
white-bellied agouti and mosaic striped coat
Related Genotype: Aw-J/Aw-J EdaTa-6J/+ females
white-bellied agouti, no striping in coat
Related Genotype: Aw-J/Aw-J +/+ females or Aw-J/Aw-J +/Y males
tabby (yellow coat, no hair on ears and tail, bald patch behind ears, no guard hairs)
Related Genotype: Aw-J/Aw-J EdaTa-6J /Y males
Control Information
| Control | ||
|---|---|---|
| Wild-type from the colony | ||
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying Aw-J allele
View Strains carrying Aw-J (31 strains)
002016 B6(Cg)-Aw-J EdaTa-6J Chr YB6-Sxr/EiJ 000552 B6-Aw-J-EdaTa-6J.Cg-Sxr 001730 B6-Aw-J-EdaTa-6J.Cg-Sxrb Hya-/J 001809 B6-Aw-J.Cg-EdaTa-6J +/+ ArTfm/J
000841 B6-Aw-J.CBy-EdaTa-By/J 000314 B6CBACa Aw-J/A-EdaTa/J-XO 000287 B6CBACa Aw-J/A-Plp1jp EdaTa/J 001232 C3H/HeJ-EdaTa-5J/J 000569 C57BL/6J-Aw-J-EdaTa +/+ ArTfm/J 003112 STOCK EdaTa-5J/J 000583 STOCK T(X;16)16H +/+ EdaTa
Additional Web Information
JAX® NOTES, January 1990, 440. Tabby Stocks Available from The Jackson Laboratory.
Phenotype
Phenotype Information
Ectodermal Dysplasia, Hypohidrotic, X-Linked; XHED - Models with phenotypic similarity to human disease where etiologies involve orthologs.1
1 Human genes are associated with this disease. Orthologs of those genes appear in the mouse genotype(s).
assigned by genotype
EdaTa-6J/Eda+
C57BL/6J Aw-J-EdaTa-6J/J
- craniofacial phenotype
- abnormal hard palate (MGI Ref ID J:147677)
- mice exhibit abnormalities in the palatal rugae pattern including absence of rugae, S-shaped rugae, and discordance of rugae
- rugae V and VI are most often affected
- digestive/alimentary phenotype
- abnormal hard palate (MGI Ref ID J:147677)
- mice exhibit abnormalities in the palatal rugae pattern including absence of rugae, S-shaped rugae, and discordance of rugae
- rugae V and VI are most often affected
EdaTa-6J/Y
C57BL/6J Aw-J-EdaTa-6J/J
- endocrine/exocrine gland phenotype
- absent meibomian glands (MGI Ref ID J:86628)
- absent palmar eccrine glands (MGI Ref ID J:86628)
- absent preputial gland (MGI Ref ID J:86628)
- absent preputial glands
- skin/coat/nails phenotype
- abnormal hair types (MGI Ref ID J:86628)
- males have more medium-length hair, however because they lack guard and zigzag hairs the overall number of hair follicles is the same
- abnormal skin morphology (MGI Ref ID J:86628)
- do not exhibit skin ridges on the tail as in wild-type
- focal hair loss (MGI Ref ID J:86628)
- mutants have a bald patch behind the ear and absent hair on the tail
- short hair (MGI Ref ID J:86628)
- hair coat is short and thin
- yellow coat color (MGI Ref ID J:86628)
- hair coat is yellowish
- growth/size phenotype
- decreased body weight (MGI Ref ID J:86628)
- at 5 months of age, weight is 77% that of wild-type
- craniofacial phenotype
- decreased molar number (MGI Ref ID J:86628)
- mutants have 2-3 molars compared to 3 in wild-type
- vision/eye phenotype
- abnormal eye morphology (MGI Ref ID J:99510)
- several males have abundant mucus in the eye at 23 weeks of age
- abnormal cornea morphology (MGI Ref ID J:99510)
- more than 80% develop progressive corneal lesions beginning at 4-9 weeks of age such as neovascularization, keratitis, ulceration, and keratinization
- abnormal corneal epithelium morphology (MGI Ref ID J:99510)
- mutants exhibit a progressive corneal epithelia defect starting at 8-9 weeks of age and develop epithelial edema and acanthosis
- corneal opacity (MGI Ref ID J:99510)
- 9 of 15 males have grossly visible white or white and red central, elevated corneal opacities at around 23 weeks of age
- corneal vascularization (MGI Ref ID J:99510)
- corneal neovascularization begins at 8-9 weeks of age and eventually leads to vision loss
- increased incidence of corneal inflammation (MGI Ref ID J:99510)
- increased susceptibility to corneal inflammation is seen from 8 weeks of age in males housed in convention housing but not in mice in a pathogen-free facility
- abnormal eyelid morphology (MGI Ref ID J:99510)
- thickened eyelid margins and loss of hair along the eyelid margins
- absent meibomian glands (MGI Ref ID J:86628)
- blepharitis (MGI Ref ID J:99510)
- narrow eye opening (MGI Ref ID J:99510)
- narrowed palpebral fissures
- conjunctivitis (MGI Ref ID J:99510)
- blindness (MGI Ref ID J:99510)
- develop severe blinding lesions in the cornea over time
- blindness by 9 months of age
- eye inflammation (MGI Ref ID J:99510)
- more than 80% show ocular surface inflammation (limbitis, conjunctivitis, blepharitis)
- conjunctivitis (MGI Ref ID J:99510)
- immune system phenotype
- eye inflammation (MGI Ref ID J:99510)
- more than 80% show ocular surface inflammation (limbitis, conjunctivitis, blepharitis)
- blepharitis (MGI Ref ID J:99510)
- conjunctivitis (MGI Ref ID J:99510)
- increased incidence of corneal inflammation (MGI Ref ID J:99510)
- increased susceptibility to corneal inflammation is seen from 8 weeks of age in males housed in convention housing but not in mice in a pathogen-free facility
- limbs/digits/tail phenotype
- absent palmar eccrine glands (MGI Ref ID J:86628)
- pigmentation phenotype
- yellow coat color (MGI Ref ID J:86628)
- hair coat is yellowish
- reproductive system phenotype
- absent preputial gland (MGI Ref ID J:86628)
- absent preputial glands
- renal/urinary system phenotype
- absent preputial gland (MGI Ref ID J:86628)
- absent preputial glands
- cardiovascular system phenotype
- corneal vascularization (MGI Ref ID J:99510)
- corneal neovascularization begins at 8-9 weeks of age and eventually leads to vision loss
This mouse can be used to support research in many areas including:EdaTa-6J related
Dermatology Research
Color and White Spotting Defects
Skin and Hair Texture Defects
Developmental Biology Research
Eye Defects
Mouse/Human Gene Homologs
hypohidrotic ectodermal dysplasia
Sensorineural Research
Eye Defects
Genes & Alleles
Gene & Allele Information
| Allele Symbol | Aw-J | ||
|---|---|---|---|
| Allele Name | white bellied agouti Jackson | ||
| Allele Type | Spontaneous | ||
| Common Name(s) | AWJ; | ||
| Strain of Origin | C57BL/6J | ||
| Gene Symbol and Name | a, nonagouti | ||
| Chromosome | 2 | ||
| Gene Common Name(s) | AGSW; AGTI; AGTIL; ASP; As; MGC126092; MGC126093; SHEP9; agouti; agouti signal protein; agouti suppressor; | ||
| Allele Symbol | EdaTa-6J | ||
| Allele Name | tabby 6 Jackson | ||
| Allele Type | Spontaneous | ||
| Common Name(s) | Ta2; Ta6J; Tabby; | ||
| Strain of Origin | C57BL/6J-tp3J/J | ||
| Gene Symbol and Name | Eda, ectodysplasin-A | ||
| Chromosome | X | ||
| Gene Common Name(s) | ED1; ED1-A1; ED1-A2; EDA1; EDA2; Eda-A1; Eda-A2; HED; RGD1563178; Ta; XHED; XLHED; tabby; | ||
| Molecular Note | This allele is defined by a base pair deletion (at position 1049) resulting in a frameshift mutation. [MGI Ref ID J:42614] | ||
Genotyping
Genotyping Information
This strain will not have a genotyping protocol or one is not currently available.
Helpful Links
Genotyping resources and troubleshooting
References
References
Additional References
Cui CY; Durmowicz M; Ottolenghi C; Hashimoto T; Griggs B; Srivastava AK; Schlessinger D. 2003. Inducible mEDA-A1 transgene mediates sebaceous gland hyperplasia and differential formation of two types of mouse hair follicles. Hum Mol Genet 12(22):2931-40. [PubMed: 14506134] [MGI Ref ID J:86628]
Srivastava AK; Durmowicz MC; Hartung AJ; Hudson J; Ouzts LV; Donovan DM; Cui CY; Schlessinger D. 2001. Ectodysplasin-A1 is sufficient to rescue both hair growth and sweat glands in Tabby mice. Hum Mol Genet 10(26):2973-81. [PubMed: 11751679] [MGI Ref ID J:73715]
Aw-J relatedEdaTa-6J relatedAberg T; Wang XP; Kim JH; Yamashiro T; Bei M; Rice R; Ryoo HM; Thesleff I. 2004. Runx2 mediates FGF signaling from epithelium to mesenchyme during tooth morphogenesis. Dev Biol 270(1):76-93. [PubMed: 15136142] [MGI Ref ID J:92174]
Barsh GS; Epstein CJ. 1989. Physical and genetic characterization of a 75-kilobase deletion associated with al, a recessive lethal allele at the mouse agouti locus. Genetics 121(4):811-8. [PubMed: 2566558] [MGI Ref ID J:9799]
Baurle J; Vogten H; Grusser-Cornehls U. 1998. Course and targets of the calbindin D-28k subpopulation of primary vestibular afferents. J Comp Neurol 402(1):111-28. [PubMed: 9831049] [MGI Ref ID J:118430]
Boran T; Lesot H; Peterka M; Peterkova R. 2005. Increased apoptosis during morphogenesis of the lower cheek teeth in tabby/EDA mice. J Dent Res 84(3):228-33. [PubMed: 15723861] [MGI Ref ID J:112546]
Chinta SJ; Rane A; Yadava N; Andersen JK; Nicholls DG; Polster BM. 2009. Reactive oxygen species regulation by AIF- and complex I-depleted brain mitochondria. Free Radic Biol Med 46(7):939-47. [PubMed: 19280713] [MGI Ref ID J:145908]
Cui CY; Hashimoto T; Grivennikov SI; Piao Y; Nedospasov SA; Schlessinger D. 2006. Ectodysplasin regulates the lymphotoxin-beta pathway for hair differentiation. Proc Natl Acad Sci U S A 103(24):9142-7. [PubMed: 16738056] [MGI Ref ID J:111051]
Cui CY; Kunisada M; Esibizione D; Grivennikov SI; Piao Y; Nedospasov SA; Schlessinger D. 2007. Lymphotoxin-beta regulates periderm differentiation during embryonic skin development. Hum Mol Genet 16(21):2583-90. [PubMed: 17673451] [MGI Ref ID J:129949]
Dickie MM. 1969. Mutations at the agouti locus in the mouse. J Hered 60(1):20-5. [PubMed: 5798139] [MGI Ref ID J:30922]
Esibizione D; Cui CY; Schlessinger D. 2008. Candidate EDA targets revealed by expression profiling of primary keratinocytes from Tabby mutant mice. Gene 427(1-2):42-6. [PubMed: 18848976] [MGI Ref ID J:143603]
Granholm DE; Reese RN; Granholm NH. 1996. Agouti alleles alter cysteine and glutathione concentrations in hair follicles and serum of mice (A y/a, A wJ/A wJ, and a/a). J Invest Dermatol 106(3):559-63. [PubMed: 8648194] [MGI Ref ID J:32132]
Granholm DE; Reese RN; Granholm NH. 1995. Agouti alleles influence thiol concentrations in hair follicles and extrafollicular tissues of mice (Ay/a, AwJ/AwJ, a/a). Pigment Cell Res 8(6):302-6. [PubMed: 8789738] [MGI Ref ID J:31403]
Jones JM; Huang JD; Mermall V; Hamilton BA; Mooseker MS; Escayg A; Copeland NG; Jenkins NA; Meisler MH. 2000. The mouse neurological mutant flailer expresses a novel hybrid gene derived by exon shuffling between Gnb5 and Myo5a. Hum Mol Genet 9(5):821-8. [PubMed: 10749990] [MGI Ref ID J:61324]
Kappenman KE; Dvoracek MA; Harvison GA; Fuller BB; Granholm NH. 1992. Tyrosinase abundance and activity in murine hairbulb melanocytes of agouti mutants (C57BL/6J-a/a, Ay/a, and AwJ/AwJ). Pigment Cell Res Suppl 2:79-83. [PubMed: 1409442] [MGI Ref ID J:1295]
Katoh A; Yoshida T; Himeshima Y; Mishina M; Hirano T. 2005. Defective control and adaptation of reflex eye movements in mutant mice deficient in either the glutamate receptor delta2 subunit or Purkinje cells. Eur J Neurosci 21(5):1315-26. [PubMed: 15813941] [MGI Ref ID J:101081]
Knapp PE; Adjan VV; Hauser KF. 2009. Cell-specific loss of kappa-opioid receptors in oligodendrocytes of the dysmyelinating jimpy mouse. Neurosci Lett 451(2):114-8. [PubMed: 19110031] [MGI Ref ID J:146365]
Lee M; Kim A; Chua SC Jr; Obici S; Wardlaw SL. 2007. Transgenic MSH overexpression attenuates the metabolic effects of a high-fat diet. Am J Physiol Endocrinol Metab 293(1):E121-31. [PubMed: 17374695] [MGI Ref ID J:126508]
Lu W; Tsirka SE. 2002. Partial rescue of neural apoptosis in the Lurcher mutant mouse through elimination of tissue plasminogen activator. Development 129(8):2043-50. [PubMed: 11934869] [MGI Ref ID J:111363]
Mayer TC; Fishbane JL. 1972. Mesoderm-ectoderm interaction in the production of the agouti pigmentation pattern in mice. Genetics 71(2):297-303. [PubMed: 4558326] [MGI Ref ID J:5288]
Mitsumori K; Yasuhara K; Mori I; Hayashi S; Shimo T; Onodera H; Nomura T; Hayashi Y. 1998. Pulmonary fibrosis caused by N-methyl-N-nitrosourethane inhibits lung tumorigenesis by urethane in transgenic mice carrying the human prototype c-Ha-ras gene. Cancer Lett 129(2):181-90. [PubMed: 9719460] [MGI Ref ID J:52138]
Monroe DG; Wipf LP; Diggins MR; Matthees DP; Granholm NH. 1998. Agouti-related maturation and tissue distribution of alpha-Melanocyte Stimulating Hormone in wild-type (AwJ/AwJ) and mutant (Ay/a,a/a) mice. Pigment Cell Res 11(5):310-3. [PubMed: 9877102] [MGI Ref ID J:52183]
Mullen RJ. 1974. A<w-J> - white-bellied agouti-J Mouse News Lett 50:38. [MGI Ref ID J:64104]
Mustonen T; Ilmonen M; Pummila M; Kangas AT; Laurikkala J; Jaatinen R; Pispa J; Gaide O; Schneider P; Thesleff I; Mikkola ML. 2004. Ectodysplasin A1 promotes placodal cell fate during early morphogenesis of ectodermal appendages. Development 131(20):4907-19. [PubMed: 15371307] [MGI Ref ID J:128256]
O'donnell SM; Hansberger MW; Connolly JL; Chappell JD; Watson MJ; Pierce JM; Wetzel JD; Han W; Barton ES; Forrest JC; Valyi-Nagy T; Yull FE; Blackwell TS; Rottman JN; Sherry B; Dermody TS. 2005. Organ-specific roles for transcription factor NF-kappaB in reovirus-induced apoptosis and disease. J Clin Invest 115(9):2341-2350. [PubMed: 16100570] [MGI Ref ID J:100906]
Peng J; Wu Z; Wu Y; Hsu M; Stevenson FF; Boonplueang R; Roffler-Tarlov SK; Andersen JK. 2002. Inhibition of caspases protects cerebellar granule cells of the weaver mouse from apoptosis and improves behavioral phenotype. J Biol Chem 277(46):44285-91. [PubMed: 12221097] [MGI Ref ID J:119427]
Peng J; Xie L; Stevenson FF; Melov S; Di Monte DA; Andersen JK. 2006. Nigrostriatal dopaminergic neurodegeneration in the weaver mouse is mediated via neuroinflammation and alleviated by minocycline administration. J Neurosci 26(45):11644-51. [PubMed: 17093086] [MGI Ref ID J:114943]
Poole TW. 1975. Dermal-epidermal interactions and the action of alleles at the agouti locus in the mouse. Dev Biol 42(2):203-10. [PubMed: 1090472] [MGI Ref ID J:5519]
Probst FJ; Cooper ML; Cheung SW; Justice MJ. 2008. Genotype, phenotype, and karyotype correlation in the XO mouse model of Turner Syndrome. J Hered 99(5):512-7. [PubMed: 18499648] [MGI Ref ID J:138994]
Smith DE; Xu SG. 2003. Ultrastructural organization of GABA-like immunoreactive profiles in the weaver substantia nigra. J Neurocytol 32(3):293-303. [PubMed: 14724391] [MGI Ref ID J:121345]
Vandenput L; Swinnen JV; Boonen S; Van Herck E; Erben RG; Bouillon R; Vanderschueren D. 2004. Role of the androgen receptor in skeletal homeostasis: the androgen-resistant testicular feminized male mouse model. J Bone Miner Res 19(9):1462-70. [PubMed: 15312246] [MGI Ref ID J:111491]
Wu Q; Miller RH; Ransohoff RM; Robinson S; Bu J; Nishiyama A. 2000. Elevated levels of the chemokine GRO-1 correlate with elevated oligodendrocyte progenitor proliferation in the jimpy mutant. J Neurosci 20(7):2609-17. [PubMed: 10729341] [MGI Ref ID J:109469]
Yamago G; Takata Y; Furuta I; Urase K; Momoi T; Huh N. 2001. Suppression of hair follicle development inhibits induction of sonic hedgehog, patched, and patched-2 in hair germs in mice. Arch Dermatol Res 293(9):435-41. [PubMed: 11758785] [MGI Ref ID J:116953]
Yoshida T; Katoh A; Ohtsuki G; Mishina M; Hirano T. 2004. Oscillating Purkinje neuron activity causing involuntary eye movement in a mutant mouse deficient in the glutamate receptor delta2 subunit. J Neurosci 24(10):2440-8. [PubMed: 15014119] [MGI Ref ID J:97010]
van Empel VP; Bertrand AT; van der Nagel R; Kostin S; Doevendans PA; Crijns HJ; de Wit E; Sluiter W; Ackerman SL; De Windt LJ. 2005. Downregulation of apoptosis-inducing factor in harlequin mutant mice sensitizes the myocardium to oxidative stress-related cell death and pressure overload-induced decompensation. Circ Res 96(12):e92-e101. [PubMed: 15933268] [MGI Ref ID J:110278]
Charles C; Pantalacci S; Peterkova R; Peterka M; Laudet V; Viriot L. 2007. Disruption of the palatal rugae pattern in Tabby (eda) mutant mice. Eur J Oral Sci 115(6):441-8. [PubMed: 18028050] [MGI Ref ID J:147677]
Cui CY; Durmowicz M; Ottolenghi C; Hashimoto T; Griggs B; Srivastava AK; Schlessinger D. 2003. Inducible mEDA-A1 transgene mediates sebaceous gland hyperplasia and differential formation of two types of mouse hair follicles. Hum Mol Genet 12(22):2931-40. [PubMed: 14506134] [MGI Ref ID J:86628]
Cui CY; Hashimoto T; Grivennikov SI; Piao Y; Nedospasov SA; Schlessinger D. 2006. Ectodysplasin regulates the lymphotoxin-beta pathway for hair differentiation. Proc Natl Acad Sci U S A 103(24):9142-7. [PubMed: 16738056] [MGI Ref ID J:111051]
Cui CY; Kunisada M; Esibizione D; Grivennikov SI; Piao Y; Nedospasov SA; Schlessinger D. 2007. Lymphotoxin-beta regulates periderm differentiation during embryonic skin development. Hum Mol Genet 16(21):2583-90. [PubMed: 17673451] [MGI Ref ID J:129949]
Cui CY; Smith JA; Schlessinger D; Chan CC. 2005. X-linked anhidrotic ectodermal dysplasia disruption yields a mouse model for ocular surface disease and resultant blindness. Am J Pathol 167(1):89-95. [PubMed: 15972955] [MGI Ref ID J:99510]
Esibizione D; Cui CY; Schlessinger D. 2008. Candidate EDA targets revealed by expression profiling of primary keratinocytes from Tabby mutant mice. Gene 427(1-2):42-6. [PubMed: 18848976] [MGI Ref ID J:143603]
Ferguson BM; Brockdorff N; Formstone E; Ngyuen T; Kronmiller JE; Zonana J. 1997. Cloning of Tabby, the murine homolog of the human EDA gene: evidence for a membrane-associated protein with a short collagenous domain. Hum Mol Genet 6(9):1589-94. [PubMed: 9285798] [MGI Ref ID J:42614]
Kunisada M; Cui CY; Piao Y; Ko MS; Schlessinger D. 2009. Requirement for Shh and Fox family genes at different stages in sweat gland development. Hum Mol Genet 18(10):1769-78. [PubMed: 19270025] [MGI Ref ID J:147576]
Sweet HO; Davisson MT. 1995. Remutations at The Jackson Laboratory (Update to Mouse Genome 1993; 91:862-5 - J16313) Mouse Genome 93(4):1030-4. [MGI Ref ID J:30778]
Vandenput L; Swinnen JV; Boonen S; Van Herck E; Erben RG; Bouillon R; Vanderschueren D. 2004. Role of the androgen receptor in skeletal homeostasis: the androgen-resistant testicular feminized male mouse model. J Bone Miner Res 19(9):1462-70. [PubMed: 15312246] [MGI Ref ID J:111491]
Health & husbandry
Health & Colony Maintenance Information
Colony Maintenance
Mating System Heterozygote x +/+ sibling (Female x Male) 01-MAR-06
Purchasing information
Pricing, Supply Level & Notes, Controls, General Terms & Conditions
Pricing
| Pricing for USA, Canada and Mexico shipping destinations |
|
Animals Provided
Price (US dollars $) Cryorecovery Fee $1900.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Additional Supply Details
| Pricing for International shipping destinations |
|
Animals Provided
Price (US dollars $) Cryorecovery Fee $2470.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Additional Supply Details
|
|
|
Supply Details
| Standard Supply | Cryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information. |
|---|---|
| Supply Notes |
|
Control Information
| Control | ||
|---|---|---|
| Wild-type from the colony | ||
| Considerations for Choosing Controls | ||
| USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
| International - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
Payment Terms and Conditions
Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.
See Terms of Use tab for General Terms and Conditions
The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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