Strain Name: |
CXB5/ByJ |
|---|---|
Stock Number: |
000355 |
Availability: | Repository- Live |
General Terms and Conditions |
| Former Name |
CXB-5 (Changed: 26-APR-07
) |
|
CXB-5/ByJ (Changed: 15-DEC-04
) | |
|
CXB-I (Changed: 15-DEC-04
) | |
| Genes & Alleles | Fgfr2; Fgfr2svs; Hld; |
Product Information
Strain Details
Type Recombinant Inbred (Ri) Additional information on Recombinant Inbred Mice. Mating System Sibling x Sibling (Female x Male) Species laboratory mouse RI progenitor BALB/cBy C57BL/6By H2 Haplotype b Generation [F64p]+F7 (10-DEC-07) Appearance
albino
Related Genotype: a/a Tyrp1b/Tyrp1b Tyrc/TyrcImportant Note
This strain is homozygous for a naturally occurring insertion in Fgfr2 resulting in aberrant splicing, however, our sequencing data indicates that the insert orientation is opposite to the published information (Kuslak 2007). The mutation, seminal vesicle shape (svs), is associated with abnormal morphology of the prostate and seminal vesicles.Strain Description
Like BALB/cByJ, this recombinant inbred carries the mutation hippocampal lamination defect or Hld, an allele responsible for abnormal neuronal migration to the pyramidal cell layer (Nowakowski RS, et al, Jnl Neurogen, 1984).
Gene & Allele Details
| Allele Symbol | Fgfr2svs | ||
|---|---|---|---|
| Allele Name | seminal vesicle shape | ||
| Common Name(s) | svs; | ||
| Strain of Origin | CXB5/By | ||
| Gene Symbol and Name | Fgfr2, fibroblast growth factor receptor 2 | ||
| Chromosome | 7 | ||
| Gene Common Name(s) | AU043015; AW556123; BEK; BFR-1; Bek; CD332; CEK3; CFD1; ECT1; FLJ98662; Fgfr-2; Fgfr-7; Fgfr7; JWS; JWS; TK14; K-SAM; KGFR; KGFRTr; TK14; TK25; bacterially expressed kinase; expressed sequence AU043015; expressed sequence AW556123; fibroblast growth factor receptor 7; seminal vesicle shape; svs; | ||
| General Note | Seminiferous tubules in male mice of the CXBI/ByEss recombinant inbred strain were found to be tubular and smooth, in contrast to normal mice such as C57BL/6By males, in which the seminal vesicles are curved and convoluted. A recessive autosomal mutationapparently occurred early in the inbreeding of the CXB recombinant inbred lines, as the abnormality was not present in either of the parental strains, C57BL/6ByEss or BALB/cByEss, but is present in both CXBI/ByJax and CXBI/ByLac. The mutation has been given the name and symbol seminal vesicle shape, svs. It appears to be linked to Tyr on Chr 7. In segregating crosses, svs/svs homozygotes had slightly lighter seminal vesicles than normal, though the weights of other androgen target organs were not reduced. Seminal vesicles responded to exogenous testosterone by increased size, but their shape did not change. The protein pattern under SDS--acrylamide gel electrophoresis differed between parent lines, but was not affected by the svs gene. A difference in the electrophoretic pattern for 27 kDa proteins was attributed to a new gene, Svp4 (J:9441). | ||
| Molecular Note | Insertion into intron 10 of a 491-bp mouse leukemia virus long terminal repeat (MLV-LTR) sequence results in aberrant alternative splicing of the transcript with exclusion from most mature mutant mRNA species of exon 8IIIb, which encodes the domain required for specific binding to FGF ligands in developing prostate and seminal vesicle mesenchyme. [MGI Ref ID J:119935] | ||
| Allele Symbol | Hld | ||
| Allele Name | hippocampal lamination defect | ||
| Strain of Origin | BALB/cJ | ||
| General Note | Abnormal laminar organization of the pyramidal layer of the cerebellum, particularly in the proximal segment of the layer, occurs in the BALB/cJ strain (J:5787). A single gene, Hld for hippocampal lamination defect, was shown to cause this abnormality in a cross of BALB/c with C57BL/6 and in the CXB recombinant inbred strains (J:13989). In normal strains, the latest formed or youngest neurons migrate past the earlier formed or older neurons to a position in the pyramidal layer that is superficial to that of the older cells. In BALB/cJ, the positions are reversed, with the older cells lying superior to the younger ones (J:5787). Since mossy fibers form synapses primarily with the older cells, this aberrant pattern of cell migration in BALB/c leads to adifferent pattern of mossy-fiber synapses, easily visualized with Timm's stain (J:5486). The dendritic excrescences induced by contact with mossy fibers on late-generated pyramidal cells in +/+ mice occur at sites on both the apical and basal dendrites; in Hld/Hld mice, they occur in two sites on the apical dendrites only (J:12029). | ||
Colony Maintenance
| Diet Information | LabDiet® 5K52/5K67 |
|---|
Related Strains
CXB By Strains
000351 CXB1/ByJ 000352 CXB2/ByJ 000353 CXB3/ByJ 000354 CXB4/ByJ 000356 CXB6/ByJ 000357 CXB7/ByJ View CXB By Strains (6 strains)
001026 BALB/cByJ 000651 BALB/cJ 000351 CXB1/ByJ 000353 CXB3/ByJ 000354 CXB4/ByJ 000357 CXB7/ByJ
Phenotypic Data
Mouse Phenome Database
Wellcome Trust Centre for Human Genetics: Mouse Recombinant Inbred Line (RIL) Genotype Data for CXB RI Line
Animal Health Reports
Room Number FGB29
Research Applications
This mouse can be used to support research in many areas including:
Neurobiology Research
Behavioral and Learning Defects
Reproductive Biology Research
Endocrine Deficiencies Affecting Gonads
Research Tools
Genetics Research (Gene Mapping: Tools for QTL Mapping, Segregation and Linkage Analysis)
References
Additional ReferencesPrice and Supply Information
| Strain Name: | CXB5/ByJ |
| Stock Number: | 000355 |
Price Details
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Supply Details
| Standard Supply | Repository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of ~nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within 48 hours of order placement. |
|---|---|
| Supply Notes |
Usually shipped between four and six weeks of age. This strain is included in the Special Mutant Stock Resource collection. Genomic DNA is available for this strain from the Mouse DNA Resource. |
| Licensing | See General Terms and Conditions below |
General Terms and Conditions
View JAX® Mice & Services Conditions of Use.
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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