Strain Name: |
CXB7/ByJ |
|---|---|
Stock Number: |
000357 |
Availability: | Repository- Live |
General Terms and Conditions |
| Former Name |
CXB-7/ByJ (Changed: 15-DEC-04
) |
|
CXB-K (Changed: 15-DEC-04
) | |
| Genes & Alleles | Hld; |
Product Information
Strain Details
Type Recombinant Inbred (Ri) Additional information on Recombinant Inbred Mice. Mating System Sibling x Sibling (Female x Male) Species laboratory mouse RI progenitor BALB/cBy C57BL/6By H2 Haplotype b Generation F135 (10-DEC-07) Appearance
black
Related Genotype: a/a Tyrp1+/Tyrp1+ Tyr+/Tyr+Strain Description
The CXB7/ByJ recombinant inbred strain is widely used because of a deficiency in mu opioid receptors. Like BALB/cByJ, this recombinant inbred carries the mutation hippocampal lamination defect or Hld, an allele responsible for abnormal neuronal migration to the pyramidal cell layer (Nowakowski RS, et al, Jnl Neurogen, 1984).Strain Development
BALB/cBy and C57BL/6By inbred strains are the progenitors to the set of CXB recombinant inbred strains developed by Dr. Don Bailey of The Jackson Laboratory.
Gene & Allele Details
| Allele Symbol | Hld | ||
|---|---|---|---|
| Allele Name | hippocampal lamination defect | ||
| Strain of Origin | BALB/cJ | ||
| General Note | Abnormal laminar organization of the pyramidal layer of the cerebellum, particularly in the proximal segment of the layer, occurs in the BALB/cJ strain (J:5787). A single gene, Hld for hippocampal lamination defect, was shown to cause this abnormality in a cross of BALB/c with C57BL/6 and in the CXB recombinant inbred strains (J:13989). In normal strains, the latest formed or youngest neurons migrate past the earlier formed or older neurons to a position in the pyramidal layer that is superficial to that of the older cells. In BALB/cJ, the positions are reversed, with the older cells lying superior to the younger ones (J:5787). Since mossy fibers form synapses primarily with the older cells, this aberrant pattern of cell migration in BALB/c leads to adifferent pattern of mossy-fiber synapses, easily visualized with Timm's stain (J:5486). The dendritic excrescences induced by contact with mossy fibers on late-generated pyramidal cells in +/+ mice occur at sites on both the apical and basal dendrites; in Hld/Hld mice, they occur in two sites on the apical dendrites only (J:12029). | ||
Colony Maintenance
| Diet Information | LabDiet® 5K52/5K67 |
|---|
Related Strains
CXB By Strains
000351 CXB1/ByJ 000352 CXB2/ByJ 000353 CXB3/ByJ 000354 CXB4/ByJ 000355 CXB5/ByJ 000356 CXB6/ByJ View CXB By Strains (6 strains)
001026 BALB/cByJ 000651 BALB/cJ 000351 CXB1/ByJ 000353 CXB3/ByJ 000354 CXB4/ByJ 000355 CXB5/ByJ
Phenotypic Data
Mouse Phenome Database
Wellcome Trust Centre for Human Genetics: Mouse Recombinant Inbred Line (RIL) Genotype Data for CXB RI Line
Animal Health Reports
Room Number FGB29
Research Applications
This mouse can be used to support research in many areas including:
Neurobiology Research
Behavioral and Learning Defects (mu opioid receptor deficiency)
Research Tools
Genetics Research (Gene Mapping: Tools for QTL Mapping, Segregation and Linkage Analysis)
References
Additional ReferencesPrice and Supply Information
| Strain Name: | CXB7/ByJ |
| Stock Number: | 000357 |
Price Details
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Supply Details
| Standard Supply | Repository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of ~nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within 48 hours of order placement. |
|---|---|
| Supply Notes |
Usually shipped between four and six weeks of age. This strain is included in the Special Mutant Stock Resource collection. Genomic DNA is available for this strain from the Mouse DNA Resource. |
| Licensing | See General Terms and Conditions below |
General Terms and Conditions
View JAX® Mice & Services Conditions of Use.
The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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