Strain Name:

B6EiC3Sn a/A-Pax6Sey-Dey/J

Stock Number:

000391

Availability:

Repository- Live

Description

Strain Information

Former Names B6EiC3Sn-a/A-Pax6Sey-Dey    (Changed: 15-DEC-04 )
Type Mutant Strain; Spontaneous Mutation;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Mating SystemF1 x Heterozygote         (Female x Male)   01-MAR-06
TJL Breeding Summary: B6EiC3Sn-a/A F1 x heterozygote
Specieslaboratory mouse
GenerationN65F1 (11-NOV-08)

Appearance
small eyes, black
Related Genotype: Pax6Sey-Dey a/+ a

small eyes, agouti
Related Genotype: Pax6Sey-Dey A/+ ?

normal eyes, black
Related Genotype: + a/+ a

normal eyes, agouti
Related Genotype: + A/+ ?

Description
Mice homozygous for the spontaneous semidominant Dickie's small eye mutation(Pax6Sey-Dey) die during embryogenesis. Heterozygous mutant mice are characterized by an overall small body size, small eyes with coloboma, small or lacking lens with cataract, abnormal folding of the retina and reduction of the pigment layer. The anterior chamber is usually missing. Mutations in the Pax6 gene lead to an impairment of axonal growth and differentiation, and delay migration of preneuronal cells. Optic nerve cross-sectional area and fiber count are decreased in these mutant mice, but probably indirectly as a consequence of reduced neural retina size. Formation of lens and of nasal cavity placodes are dependent on normal Pax6 expression.

Control Information

  Control
   Wild-type from the colony
 
  Considerations for Choosing Controls

Related Strains

Strains carrying   a allele
003879   B10;TFLe-a/a T tf/+ tf/J
001538   B6 x B6C3Sn a/A-T(1;9)27H/J
000916   B6 x B6C3Sn a/A-T(5;12)31H/J
000602   B6 x B6C3Sn a/A-T(8;16)17H/J
000618   B6 x FSB/GnEi a/a Ctslfs/J
000577   B6 x STOCK a Oca2p Hps5ru2 Ednrbs/J
000601   B6 x STOCK a/a T(7;18)50H/J
000592   B6 x STOCK T(2;4)13H a/J
000001   B6.C3 A/a Mgrn1md/J
000231   B6;C3Fe a/a-Csf1op/J
000785   B6;D2-a Es1e/EiJ
000604   B6C3 a/A-T(10;13)199H +/+ Lystbg-J/J or Lystbg-2J/J
002807   B6C3Fe a/a-Meox2fla/J
000224   B6C3Fe a/a-Scyl1mdf/J
001037   B6C3Fe a/a-Agtpbp1pcd/J
000221   B6C3Fe a/a-Alx4lst-J/J
002062   B6C3Fe a/a-Atp7aMo-8J/J
001756   B6C3Fe a/a-Cacng2stg/J
001815   B6C3Fe a/a-Col1a2oim/J
000209   B6C3Fe a/a-Dh/J
000211   B6C3Fe a/a-Dstdt-J/J
000210   B6C3Fe a/a-Edardl-J/J
000207   B6C3Fe a/a-Edaraddcr/J
000182   B6C3Fe a/a-Eef1a2wst/J
001278   B6C3Fe a/a-Glra1spd/J
000241   B6C3Fe a/a-Glrbspa/J
002875   B6C3Fe a/a-Hoxd13spdh/J
000304   B6C3Fe a/a-Krt71Ca Scn8amed-J/J
000226   B6C3Fe a/a-Largemyd/J
000636   B6C3Fe a/a-Lmx1adr-J/J
001280   B6C3Fe a/a-Lse/J
001573   B6C3Fe a/a-MitfMi/J
001035   B6C3Fe a/a-Napahyh/J
000181   B6C3Fe a/a-Otogtwt/J
000278   B6C3Fe a/a-Papss2bm Hps1ep Hps6ru/J
000205   B6C3Fe a/a-Papss2bm/J
002078   B6C3Fe a/a-Pcdh15av-2J/J
000246   B6C3Fe a/a-Pitpnavb/J
001430   B6C3Fe a/a-Ptch1mes/J
000506   B6C3Fe a/a-Qkqk/J
000235   B6C3Fe a/a-Relnrl/J
000237   B6C3Fe a/a-Rorasg/J
000290   B6C3Fe a/a-Sox10Dom/J
000230   B6C3Fe a/a-Tcirg1oc/J
003612   B6C3Fe a/a-Trak1hyrt/J
001512   B6C3Fe a/a-Ttnmdm/J
001607   B6C3Fe a/a-Unc5crcm/J
000005   B6C3Fe a/a-Wc/J
000243   B6C3Fe a/a-Wnt1sw/J
000248   B6C3Fe a/a-Xpl/J
001750   B6C3Fe a/a-XsJ/J
000624   B6C3Fe a/a-anx/J
008044   B6C3Fe a/a-bpck/J
003020   B6C3Fe a/a-dep/J
002018   B6C3Fe a/a-din/J
002339   B6C3Fe a/a-nma/J
000240   B6C3Fe a/a-soc/J
000063   B6C3Fe a/a-sy/J
001055   B6C3Fe a/a-tip/J
000245   B6C3Fe a/a-tn/J
000296   B6C3Fe-a/a Hoxa13Hd Mcoln3Va-J/J
000019   B6C3Fe-a/a-Itpr1opt/J
001022   B6C3FeF1/J a/a
006450   B6EiC3 a/A-Vss/GrsrJ
000971   B6EiC3 a/A-Och/J
000551   B6EiC3 a/A-Tbx15de-H/J
000557   B6EiC3-+ a/LnpUl A/J
000503   B6EiC3Sn a/A-Gy/J
001811   B6EiC3Sn a/A-Otcspf-ash/J
002343   B6EiC3Sn a/A-Otcspf/J
001924   B6EiC3Sn a/A-Ts(1716)65Dn
001923   B6EiC3Sn a/A-Ts(417)2Lws Tim/J
000225   C3FeLe.B6 a/a-Ptpn6me/J
008425   C3FeLe.B6-a Trl/J
000198   C3FeLe.B6-a/J
000291   C3FeLe.Cg-a/a Hm KitlSl Krt71Ca-J/J
001886   C3HeB/FeJLe a/a-gnd/J
000584   C57BL/6J-+ T(1;2)5Ca/a +/J
000284   CWD/LeJ
000670   DBA/1J
000671   DBA/2J
001057   HPT/LeJ
000260   JGBF/LeJ
000265   MY/HuLeJ
000308   SSL/LeJ
000994   STOCK a Myo5ad Mregdsu/J
000064   STOCK a Tyrp1b Sisi/J
002238   STOCK a Tyrp1b shmy/J
001433   STOCK a skt/J
000579   STOCK a tp/J
000319   STOCK a us/J
002648   STOCK a/a Cln6nclf/J
000317   STOCK a/a Egfrwa2/J
000302   STOCK a/a MitfMi-wh +/+ Itpr1opt/J
000286   STOCK a/a Myo5ad fd/+ +/J
000206   STOCK a/a Tyrc-h/J
001432   STOCK a/a Tyrp1b sks/Tyrp1b +/J
000281   STOCK a/a ma Flgft/ma Flgft/J
000312   STOCK stb + a/+ Fignfi a/J
000596   STOCK T(2;11)30H/+ x AEJ-a Gdf5bp-H/J or A/J-a Gdf5bp-J/J
000970   STOCK T(2;16)28H A/T(2;16)28H a/J
000590   STOCK T(2;4)1Sn a/J
000594   STOCK T(2;8)26H a/T(2;8)26H a Tyrp1+/Tyrp1b/J
000623   TR/DiEiJ
View Strains carrying   a     (104 strains)

Strains carrying other alleles of a
003301   (C57BL/6J x C3H-Eya1bor)F1/J
000251   AEJ.Cg-ae +/a Gdf5bp-H/J
000202   AEJ/Gn-bd/J
000199   AEJ/GnLeJ
000433   B10.C-H3c H13? A/(28NX)SnJ
000427   B10.CE-H13b Aw/(30NX)SnJ
000423   B10.KR-H13? A/SnJ
000420   B10.LP-H13b Aw/Sn
000477   B10.PA-Pldnpa H3e at/SnJ
000419   B10.UW-H3b we Pax1un at/SnJ
000593   B6 x B6CBCa Aw-J/A-Grid2Lc T(2;6)7Ca MitfMi-wh/J
000502   B6 x B6CBCa Aw-J/A-Myo5aflr Gnb5flr/J
000599   B6 x B6CBCa Aw-J/A-T(5;13)264Ca KitW-v/J
002083   B6 x B6EiC3 a/A-T(7;16)235Dn/J
000507   B6 x B6EiC3 a/A-Otcspf/J
003759   B6 x B6EiC3Sn a/A-T(10;16)232Dn/J
002071   B6 x B6EiC3Sn a/A-T(11;17)202Dn/J
002113   B6 x B6EiC3Sn a/A-T(11A2;16B3)238Dn/J
002068   B6 x B6EiC3Sn a/A-T(11B1;16B5)233Dn/J
002069   B6 x B6EiC3Sn a/A-T(14E4or5;16B5)225Dn/J
001926   B6 x B6EiC3Sn a/A-T(15;16)198Dn/J
001832   B6 x B6EiC3Sn a/A-T(15E;16B1)60Dn/J
003758   B6 x B6EiC3Sn a/A-T(16C3-4;17A2)65Dn/J
001833   B6 x B6EiC3Sn a/A-T(1C2;16C3)45Dn/J
001903   B6 x B6EiC3Sn a/A-T(6F;18C)57Dn/J
001535   B6 x B6EiC3Sn a/A-T(8A4;12D1)69Dn/J
001831   B6 x B6EiC3Sn a/A-T(8C3;16B5)164Dn/J
002016   B6(Cg)-Aw-J EdaTa-6J Chr YB6-Sxr/EiJ
000552   B6-Aw-J-EdaTa-6J.Cg-Sxr
001730   B6-Aw-J-EdaTa-6J.Cg-Sxrb Hya-/J
000841   B6-Aw-J.CBy-EdaTa-By/J
001809   B6-Aw-J.Cg-EdaTa-6J +/+ ArTfm/J
000600   B6-Gpi1b x B6CBCa Aw-J/A-T(7;15)9H Gpi1a/J
000769   B6.C/(HZ18)By-at-44J/J
000203   B6.C3-Aiy/a/J
000017   B6.C3-Avy/J
001572   B6.C3-am-J/J
000628   B6.CE-A Amy1b Amy2a5b/J
000021   B6.Cg-Ay/J
100409   B6129PF1/J-Aw-J/Aw
004200   B6;CBACa Aw-J/A-Npr2cn-2J/GrsrJ
000505   B6C3 Aw-J/A-Mutedmu/J
000604   B6C3 a/A-T(10;13)199H +/+ Lystbg-J/J or Lystbg-2J/J
000065   B6C3Fe a/a-we Pax1un at/J
000314   B6CBACa Aw-J/A-EdaTa/J-XO
000501   B6CBACa Aw-J/A-Aifm1Hq/J
001046   B6CBACa Aw-J/A-Grid2Lc/J
000500   B6CBACa Aw-J/A-Gs/J
002703   B6CBACa Aw-J/A-Hydinhy3/J
000247   B6CBACa Aw-J/A-Kcnj6wv/J
000287   B6CBACa Aw-J/A-Plp1jp EdaTa/J
000515   B6CBACa Aw-J/A-SfnEr/J
000242   B6CBACa Aw-J/A-spc/J
000288   B6CBACa Aw-J/A-we a Mafbkr/J
001201   B6CBACaF1/J-Aw-J/A
001752   B6CBCa Aw-J/A-T(7;15)9H/J
006450   B6EiC3 a/A-Vss/GrsrJ
000557   B6EiC3-+ a/LnpUl A/J
000504   B6EiC3Sn a/A-Cacnb4lh/J
000553   B6EiC3Sn a/A-Egfrwa2 Wnt3avt/J
001811   B6EiC3Sn a/A-Otcspf-ash/J
002343   B6EiC3Sn a/A-Otcspf/J
001923   B6EiC3Sn a/A-Ts(417)2Lws Tim/J
001875   B6EiC3SnF1/J
000200   C3FeB6 A/Aw-J-Ankank/J
000638   C3FeB6 A/Aw-J-Spnb4qv-J/J
001203   C3FeB6F1/J A/Aw-J
001272   C3H/HeSnJ-Ahvy/J
000099   C3HeB/FeJ-Avy/J
000338   C57BL/6J Aw-J-EdaTa-6J/J
000258   C57BL/6J-Ai/a/J
000774   C57BL/6J-Asy/a/J
000569   C57BL/6J-Aw-J-EdaTa +/+ ArTfm/J
000051   C57BL/6J-Aw-J/J
000055   C57BL/6J-at-33J/J
000070   C57BL/6J-atd/J
002468   KK.Cg-Ay/J
000262   LS/LeJ
000283   LT.CAST-A/J
001759   STOCK A Tyrc Sha/J
001427   STOCK Aw us/J
View Strains carrying other alleles of a     (81 strains)

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms
Aniridia; AN - Models with phenotypic similarity to human disease where etiologies involve orthologs.1
NOTPeters Anomaly - Models with phenotypic similarity to human disease where etiologies involve orthologs.1
NOTWilms Tumor, Aniridia, Genitourinary Anomalies, and Mental Retardation Syndrome; WAGR - Models with phenotypic similarity to human disease where etiologies involve orthologs.1
1 Human genes are associated with this disease. Orthologs of those genes appear in the mouse genotype(s).
View Mammalian Phenotype Terms

Mammalian Phenotype Terms
      assigned by genotype

Pax6Sey-Dey/Pax6+

        B6EiC3Sn a/A-Pax6Sey-Dey/J
  • vision/eye phenotype
  • abnormal corneal epithelium morphology (MGI Ref ID J:83791)
    • the corneal epithelium is 1 to 7 cell layers thick instead of 8 to 10 as in wild-type mice
    • reduction in cell layers is apparent at P14 and P21
    • unlike in wild-type mice, basal cells are more rounded and the cell layers are not packed tightly
    • no goblet cells are observed
    • at 6 weeks, cell proliferation rates are increased (45% proliferative index compared to 4% proliferative index in wild-type mice)
    • however, apoptosis rates are normal
    • adhesion between cells in the suprabasal middle and superficial layers is disrupted
  • abnormal corneal stroma morphology (MGI Ref ID J:83791)
    • the stroma exhibits varied thickness and a general disorganizeation with large aggregates of laminn in the anterior region

The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.

Pax6Sey-Dey/Pax6+

        C3H/HeJ-Pax6Sey-Dey
  • lethality-prenatal/perinatal
  • neonatal lethality (MGI Ref ID J:6072)
    • 5% of mice die 8 to 10 hours after birth
  • vision/eye phenotype
  • abnormal lens development (MGI Ref ID J:6072)
    • lens pit development is delayed by 1 to 2 days relative to in wild-type mice
    • fused cornea and lens (MGI Ref ID J:6072)
  • abnormal retina morphology (MGI Ref ID J:6072)
    • the retina is abnormally folded
    • abnormal retinal pigment epithelium morphology (MGI Ref ID J:6072)
      • mice have a reduced retinal pigment layer
  • aniridia (MGI Ref ID J:10820)
  • cataracts (MGI Ref ID J:6072)
    • lens have anterior cataracts
  • coloboma (MGI Ref ID J:6072)
    • coloboma is visible by 11 days of gestation
  • iris hypoplasia (MGI Ref ID J:6072)
    • mice exhibit a partial or complete lose of iris tissue
    • mice have an eye phenotype similar to aniridia
  • microphthalmia (MGI Ref ID J:6072)
    • mice have small eyes that are half the size of normal eyes
    • the anterior chamber of the eye is missing
  • small lens (MGI Ref ID J:6072)
    • lens are small or absent
  • nervous system phenotype
  • exencephaly (MGI Ref ID J:6072)
    • at day 7 to 8 of gestation 2 embryos were found with exencephaly
  • pigmentation phenotype
  • abnormal retinal pigment epithelium morphology (MGI Ref ID J:6072)
    • mice have a reduced retinal pigment layer
  • belly spot (MGI Ref ID J:6072)
    • mice have a white spot on their sternum that extends into a belt in some mice
  • hypopigmentation (MGI Ref ID J:6072)
    • mice have reduced pigmentation on their feet and tails
  • skin/coat/nails phenotype
  • belly spot (MGI Ref ID J:6072)
    • mice have a white spot on their sternum that extends into a belt in some mice
  • growth/size phenotype
  • decreased body size (MGI Ref ID J:6072)
    • mice are 10 to 20% smaller in size than wild-type mice
  • decreased fetal size (MGI Ref ID J:6072)
    • mice are smaller than wild-type mice before birth and remain so the rest of their lives
  • tumorigenesis
  • *normal* tumorigenesis (MGI Ref ID J:10820)
    • despite the loss of Wt1, no abnormal tumors are detected in mice
  • renal/urinary system phenotype
  • *normal* renal/urinary system phenotype (MGI Ref ID J:10820)
    • mice have normal urogenital organs

Pax6Sey-Dey/Pax6+

        involves: C3H/HeJ
  • growth/size phenotype
  • decreased body length (MGI Ref ID J:14117)
    • heterozygous embryos are on average 13% smaller than wild-type littermates in crown-rump length
  • vision/eye phenotype
  • coloboma (MGI Ref ID J:14117)
  • lethality-prenatal/perinatal
  • prenatal lethality (MGI Ref ID J:14117)
    • fewer than expected heterozygotes survive to birth

Pax6Sey-Dey/Pax6Sey-Dey

        C3H/HeJ-Pax6Sey-Dey
  • lethality-prenatal/perinatal
  • embryonic lethality before somite formation (MGI Ref ID J:6072)
    • embryos die between E6 and E7

Pax6Sey-Dey/Pax6Sey

        involves: C3H/HeJ
  • respiratory system phenotype
  • absent olfactory placodes (MGI Ref ID J:14117)
    • 23% of embryos from a heterozygous intercross show not development of nasal placodes
  • taste/olfaction phenotype
  • absent olfactory placodes (MGI Ref ID J:14117)
    • 23% of embryos from a heterozygous intercross show not development of nasal placodes
  • vision/eye phenotype
  • absent lens vesicle (MGI Ref ID J:14117)
    • 23% of embryos from a heterozygous intercross show no development of the lens
  • coloboma (MGI Ref ID J:14117)
    • approximately a third of the embryos 14.5 days or older from heterozygous intercrosses are colobomatous
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Pax6Sey-Dey related

Developmental Biology Research
Neurodevelopmental Defects

Mouse/Human Gene Homologs
aniridia type II

Neurobiology Research
Neurodevelopmental Defects

Sensorineural Research
Cataracts
      cortical
Eye Defects

Genes & Alleles

Gene & Allele Information

 
Allele Symbol Pax6Sey-Dey
Allele Name small eye, Dickie
Allele Type Spontaneous
Common Name(s) SeyDey;
Strain of OriginC3H/HeJ
Gene Symbol and Name Pax6, paired box gene 6
Chromosome 2
Gene Common Name(s) 1500038E17Rik; AEY11; AN; AN2; D11S812E; Dey; Dickie's small eye; Gsfaey11; MGC17209; MGDA; Pax-6; RIKEN cDNA 1500038E17 gene; Sey; WAGR; gsf abnormal eyes 11; small eye;
General Note Pax6Sey-Dey is very similar to Pax6Sey-H in its effects in both homozygotes and heterozygotes.
Molecular Note A large deletion that also includes the neighboring Wilm's tumor gene (Wt1). Precise breakpoints have not been mapped. [MGI Ref ID J:10820]
 
Allele Symbol a
Allele Name nonagouti
Allele Type Spontaneous

Genotyping

Genotyping Information

This strain will not have a genotyping protocol or one is not currently available.

Helpful Links

Genotyping resources and troubleshooting

References

References

Additional References

Hill RE; Favor J; Hogan BL; Ton CC; Saunders GF; Hanson IM; Prosser J; Jordan T; Hastie ND; van Heyningen V. 1991. Mouse small eye results from mutations in a paired-like homeobox-containing gene [published erratum appears in Nature 1992 Feb 20;355(6362):750] Nature 354(6354):522-5. [PubMed: 1684639]  [MGI Ref ID J:2301]

Theiler K; Varnum DS; Stevens LC. 1978. Development of Dickie's small eye, a mutation in the house mouse. Anat Embryol (Berl) 155(1):81-6. [PubMed: 103464]  [MGI Ref ID J:6072]

Pax6Sey-Dey related

Curto GG; Lara JM; Parrilla M; Aijon J; Velasco A. 2007. Modifications of the retina neuronal populations of the heterozygous mutant small eye mouse, the Sey(Dey). Brain Res 1127(1):163-76. [PubMed: 17113047]  [MGI Ref ID J:116600]

Davis J; Duncan MK; Robison WG Jr; Piatigorsky J. 2003. Requirement for Pax6 in corneal morphogenesis: a role in adhesion. J Cell Sci 116(Pt 11):2157-67. [PubMed: 12692153]  [MGI Ref ID J:83791]

Davisson MT. 1986. Position of Dey on Chr 2 Mouse News Lett 75:30-31.  [MGI Ref ID J:14099]

Glaser T; Lane J; Housman D. 1990. A mouse model of the aniridia-Wilms tumor deletion syndrome. Science 250(4982):823-7. [PubMed: 2173141]  [MGI Ref ID J:10820]

Harbers K; Soriano P; Muller U; Jaenisch R. 1986. High frequency of unequal recombination in pseudoautosomal region shown by proviral insertion in transgenic mouse. Nature 324(6098):682-5. [PubMed: 3025741]  [MGI Ref ID J:8543]

Hogan BL; Hetherington CM; Lyon MF. 1987. Allelism of small eyes (Sey) with Dickie's small eye (Dey) on Chromosome 2. Mouse News Lett 77:135-8.  [MGI Ref ID J:14117]

Kim J; Lauderdale JD. 2008. Overexpression of pairedless Pax6 in the retina disrupts corneal development and affects lens cell survival. Dev Biol 313(1):434-54. [PubMed: 18062951]  [MGI Ref ID J:130501]

Lovicu FJ; Steven P; Saika S; McAvoy JW. 2004. Aberrant lens fiber differentiation in anterior subcapsular cataract formation: a process dependent on reduced levels of Pax6. Invest Ophthalmol Vis Sci 45(6):1946-53. [PubMed: 15161862]  [MGI Ref ID J:134694]

Ma C; Papermaster D; Cepko CL. 1998. A unique pattern of photoreceptor degeneration in cyclin D1 mutant mice. Proc Natl Acad Sci U S A 95(17):9938-43. [PubMed: 9707579]  [MGI Ref ID J:49399]

Theiler K; Varnum DS; Stevens LC. 1978. Development of Dickie's small eye, a mutation in the house mouse. Anat Embryol (Berl) 155(1):81-6. [PubMed: 103464]  [MGI Ref ID J:6072]

Varnum D; Stevens. 1974. Dickie's small eye (Dey) Mouse News Lett 50:43.  [MGI Ref ID J:24775]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           FGB29

Colony Maintenance

Mating SystemF1 x Heterozygote         (Female x Male)   01-MAR-06
TJL Breeding Summary: B6EiC3Sn-a/A F1 x heterozygote

Purchasing information

Pricing, Supply Level & Notes, Controls, General Terms & Conditions

Pricing

Pricing for USA, Canada and Mexico shipping destinations View International pricing
Weeks of AgePrice (US dollars $)GenderGenotypes Provided
Individual Mouse $136.60Female or MaleHeterozygous for Pax6Sey-Dey
Pairs /Price (US dollars $)Pair Genotype
$230.70B6EiC3SnF1/J (001875) x Heterozygous for Pax6Sey-Dey

Additional Supply Details

Pricing for International shipping destinations View USA Canada and Mexico pricing
Weeks of AgePrice (US dollars $)GenderGenotypes Provided
Individual Mouse $177.60Female or MaleHeterozygous for Pax6Sey-Dey
Pairs /Price (US dollars $)Pair Genotype
$300.00B6EiC3SnF1/J (001875) x Heterozygous for Pax6Sey-Dey

Additional Supply Details

Supply Details

Standard SupplyRepository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of approximately nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within two business days following order placement.
Supply Notes

Control Information

  Control
   Wild-type from the colony
 
  Considerations for Choosing Controls
  USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains.
  International - Control Pricing Information for Genetically Engineered Mutant Strains.

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The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. In purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


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