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Strain Name:

B6EiC3Sn a/A-Pax6Sey-Dey/J

Stock Number:

000391

Availability:

Repository- Live

Price and Supply Information

General Terms and Conditions

Former Name      B6EiC3Sn-a/A-Pax6Sey-Dey    (Changed: 15-DEC-04 )
Genes & Alleles   Pax6;   Pax6Sey-Dey;   a;

Product Information

Strain Details

Type JAX® GEMM® Strain - Mutant Strain
Additional information on JAX® GEMM® Strains.
Type JAX® GEMM® Strain - Spontaneous Mutation
Mating SystemF1 x Heterozygote         (Female x Male)
TJL Breeding Summary: B6EiC3Sn-a/A F1 x heterozygote
Specieslaboratory mouse
GenerationN62F1 (14-DEC-07)

Appearance
small eyes, black
Related Genotype: Pax6Sey-Dey a/+ a

small eyes, agouti
Related Genotype: Pax6Sey-Dey A/+ ?

normal eyes, black
Related Genotype: + a/+ a

normal eyes, agouti
Related Genotype: + A/+ ?

Strain Description
Mice homozygous for the spontaneous semidominant Dickie's small eye mutation(Pax6Sey-Dey) die during embryogenesis. Heterozygous mutant mice are characterized by an overall small body size, small eyes with coloboma, small or lacking lens with cataract, abnormal folding of the retina and reduction of the pigment layer. The anterior chamber is usually missing. Mutations in the Pax6 gene lead to an impairment of axonal growth and differentiation, and delay migration of preneuronal cells. Optic nerve cross-sectional area and fiber count are decreased in these mutant mice, but probably indirectly as a consequence of reduced neural retina size. Formation of lens and of nasal cavity placodes are dependent on normal Pax6 expression.

Related Disease (OMIM) Terms

Aniridia, Type II; AN2
NOTPeters Anomaly
NOTWagr Syndrome
Mammalian Phenotype Terms assigned by genotype

Pax6Sey-Dey/Pax6+

        B6EiC3Sn a/A-Pax6Sey-Dey/J
  • vision/eye phenotype
  • abnormal corneal epithelium morphology (MGI Ref ID J:83791)
    • the corneal epithelium is 1 to 7 cell layers thick instead of 8 to 10 as in wild type mice
    • reduction in cell layers is apparent at P14 and P21
    • unlike in wild type mice, basal cells are more rounded and the cell layers are not packed tightly
    • no goblet cells are observed
    • at 6 weeks, cell proliferation rates are increased (45% proliferative index compared to 4% proliferative index in wild type mice)
    • however, apoptosis rates are normal
    • adhesion between cells in the suprabasal middle and superficial layers is disrupted
  • abnormal corneal stroma morphology (MGI Ref ID J:83791)
    • the stroma exhibits varied thickness and a general disorganizeation with large aggregates of laminn in the anterior region

The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.

Pax6Sey-Dey/Pax6+

        C3H/HeJ-Pax6Sey-Dey
  • lethality-prenatal/perinatal
  • neonatal lethality (MGI Ref ID J:6072)
    • 5% of mice die 8 to 10 hours after birth
  • vision/eye phenotype
  • abnormal lens development (MGI Ref ID J:6072)
    • lens pit development is delayed by 1 to 2 days relative to in wild type mice
    • fused cornea and lens (MGI Ref ID J:6072)
  • abnormal retina morphology (MGI Ref ID J:6072)
    • the retina is abnormally folded
    • abnormal retinal pigment epithelium morphology (MGI Ref ID J:6072)
      • mice have a reduced retinal pigment layer
  • aniridia (MGI Ref ID J:10820)
  • cataracts (MGI Ref ID J:6072)
    • lens have anterior cataracts
  • coloboma (MGI Ref ID J:6072)
    • coloboma is visible by 11 days of gestation
  • iris hypoplasia (MGI Ref ID J:6072)
    • mice exhibit a partial or complete lose of iris tissue
    • mice have an eye phenotype similar to aniridia
  • microphthalmia (MGI Ref ID J:6072)
    • mice have small eyes that are half the size of normal eyes
    • the anterior chamber of the eye is missing
  • small lens (MGI Ref ID J:6072)
    • lens are small or absent
  • nervous system phenotype
  • exencephaly (MGI Ref ID J:6072)
    • at day 7 to 8 of gestation 2 embryos were found with exencephaly
  • pigmentation phenotype
  • abnormal retinal pigment epithelium morphology (MGI Ref ID J:6072)
    • mice have a reduced retinal pigment layer
  • belly spot (MGI Ref ID J:6072)
    • mice have a white spot on their sternum that extends into a belt in some mice
  • hypopigmentation (MGI Ref ID J:6072)
    • mice have reduced pigmentation on their feet and tails
  • skin/coat/nails phenotype
  • belly spot (MGI Ref ID J:6072)
    • mice have a white spot on their sternum that extends into a belt in some mice
  • growth/size phenotype
  • decreased body size (MGI Ref ID J:6072)
    • mice are 10 to 20% smaller in size than wild type mice
  • reduced fetal size (MGI Ref ID J:6072)
    • mice are smaller than wild type mice before birth and remain so the rest of their lives
  • tumorigenesis
  • *normal* tumorigenesis (MGI Ref ID J:10820)
    • despite the loss of Wt1, no abnormal tumors are detected in mice
  • renal/urinary system phenotype
  • *normal* renal/urinary system phenotype (MGI Ref ID J:10820)
    • mice have normal urogential organs

Pax6Sey-Dey/Pax6Sey-Dey

        C3H/HeJ-Pax6Sey-Dey
  • lethality-prenatal/perinatal
  • embryonic lethality before somite formation (MGI Ref ID J:6072)
    • embryos die between E6 and E7

Gene & Allele Details

Allele Symbol Pax6Sey-Dey
Allele Name small eye, Dickie
Common Name(s) SeyDey;
Strain of OriginC3H/HeJ
Gene Symbol and Name Pax6, paired box gene 6
Chromosome 2
Gene Common Name(s) 1500038E17Rik; AEY11; AN; AN2; D11S812E; Dey; Dickie's small eye; Gsfaey11; MGC17209; MGDA; Pax-6; RIKEN cDNA 1500038E17 gene; Sey; WAGR; gsf abnormal eyes 11; small eye;
General Note Pax6Sey-Dey is very similar to Pax6Sey-H in its effects in both homozygotes and heterozygotes.
Molecular Note A large deletion that also includes the neighboring Wilm's tumor gene (Wt1). Precise breakpoints have not been mapped. [MGI Ref ID J:10820]
 
Allele Symbol a
Allele Name nonagouti

Control Information

  Allele   Control
 Pax6Sey-Dey  Wild-type from the colony
 
  Considerations for Choosing Controls
  Control Pricing Information for JAX® GEMM® Strains

Related Strains

Strains carrying   a allele
003879   B10;TFLe-a/a T tf/+ tf/J
001538   B6 x B6C3Sn a/A-T(1;9)27H/J
000916   B6 x B6C3Sn a/A-T(5;12)31H/J
000602   B6 x B6C3Sn a/A-T(8;16)17H/J
000618   B6 x FSB/GnEi a/a Ctslfs/J
000577   B6 x STOCK a Oca2p Hps5ru2 Ednrbs/J
000601   B6 x STOCK a/a T(7;18)50H/J
000592   B6 x STOCK T(2;4)13H a/J
000001   B6.C3 A/a Mgrn1md/J
000785   B6;D2-a Es1e/J
000604   B6C3 a/A-T(10;13)199H +/+ Lystbg-J/J or Lystbg-2J/J
002807   B6C3Fe a/a-Meox2fla/J
000224   B6C3Fe a/a-Scyl1mdf/J
001037   B6C3Fe a/a-Agtpbp1pcd/J
000221   B6C3Fe a/a-Alx4lst-J/J
002062   B6C3Fe a/a-Atp7aMo-8J/J
001756   B6C3Fe a/a-Cacng2stg/J
001815   B6C3Fe a/a-Col1a2oim/J
000231   B6C3Fe a/a-Csf1op/J
000209   B6C3Fe a/a-Dh/J
000211   B6C3Fe a/a-Dstdt-J/J
000210   B6C3Fe a/a-Edardl-J/J
000207   B6C3Fe a/a-Edaraddcr/J
000182   B6C3Fe a/a-Eef1a2wst/J
001278   B6C3Fe a/a-Glra1spd/J
000241   B6C3Fe a/a-Glrbspa/J
002875   B6C3Fe a/a-Hoxd13spdh/J
000304   B6C3Fe a/a-Krt71Ca Scn8amed-J/J
000226   B6C3Fe a/a-Largemyd/J
000636   B6C3Fe a/a-Lmx1adr-J/J
001280   B6C3Fe a/a-Lse/J
001573   B6C3Fe a/a-MitfMi/J
001035   B6C3Fe a/a-Napahyh/J
000181   B6C3Fe a/a-Otogtwt/J
000278   B6C3Fe a/a-Papss2bm Hps1ep Hps6ru/J
000205   B6C3Fe a/a-Papss2bm/J
002078   B6C3Fe a/a-Pcdh15av-2J/J
000246   B6C3Fe a/a-Pitpnavb/J
001430   B6C3Fe a/a-Ptch1mes/J
000506   B6C3Fe a/a-Qkqk/J
000235   B6C3Fe a/a-Relnrl/J
000237   B6C3Fe a/a-Rorasg/J
000290   B6C3Fe a/a-Sox10Dom/J
000230   B6C3Fe a/a-Tcirg1oc/J
003612   B6C3Fe a/a-Trak1hyrt/J
001512   B6C3Fe a/a-Ttnmdm/J
001607   B6C3Fe a/a-Unc5crcm/J
000005   B6C3Fe a/a-Wc/J
000243   B6C3Fe a/a-Wnt1sw/J
000248   B6C3Fe a/a-Xpl/J
001750   B6C3Fe a/a-XsJ/J
000624   B6C3Fe a/a-anx/J
003020   B6C3Fe a/a-dep/J
002018   B6C3Fe a/a-din/J
002339   B6C3Fe a/a-nma/J
000240   B6C3Fe a/a-soc/J
000063   B6C3Fe a/a-sy/J
001055   B6C3Fe a/a-tip/J
000245   B6C3Fe a/a-tn/J
000296   B6C3Fe-a/a Hoxa13Hd Mcoln3Va-J/J
000019   B6C3Fe-a/a-Itpr1opt/J
001022   B6C3FeF1/J a/a
000971   B6EiC3 a/A-Och/J
000551   B6EiC3 a/A-Tbx15de-H/J
006450   B6EiC3 a/A-Vss/J
000557   B6EiC3-+ a/LnpUl A/J
000503   B6EiC3Sn a/A-Gy/J
001811   B6EiC3Sn a/A-Otcspf-ash/J
002343   B6EiC3Sn a/A-Otcspf/J
001924   B6EiC3Sn a/A-Ts(1716)65Dn
001923   B6EiC3Sn a/A-Ts(417)2Lws Tim/J
000225   C3FeLe.B6 a/a-Ptpn6me/J
000198   C3FeLe.B6-a/J
000291   C3FeLe.Cg-a/a Hm KitlSl Krt71Ca-J/J
001886   C3HeB/FeJLe a/a-gnd/J
000584   C57BL/6J-+ T(1;2)5Ca/a +/J
000284   CWD/LeJ
000670   DBA/1J
000671   DBA/2J
001057   HPT/LeJ
000260   JGBF/LeJ
000265   MY/HuLeJ
000308   SSL/LeJ
000994   STOCK a Myo5ad Mregdsu/J
000064   STOCK a Tyrp1b Sisi/J
002238   STOCK a Tyrp1b shmy/J
001433   STOCK a skt/J
000579   STOCK a tp/J
000319   STOCK a us/J
002648   STOCK a/a Cln6nclf/J
000317   STOCK a/a Egfrwa2/J
000302   STOCK a/a MitfMi-wh +/+ Itpr1opt/J
000286   STOCK a/a Myo5ad fd/+ +/J
000206   STOCK a/a Tyrc-h/J
001432   STOCK a/a Tyrp1b sks/Tyrp1b +/J
000281   STOCK a/a ma ft/ma ft/J
000312   STOCK stb + a/+ Fignfi a/J
000596   STOCK T(2;11)30H/+ x AEJ-a Gdf5bp-H/J or A/J-a Gdf5bp-J/J
000970   STOCK T(2;16)28H A/T(2;16)28H a/J
000590   STOCK T(2;4)1Sn a/J
000594   STOCK T(2;8)26H a/T(2;8)26H a Tyrp1+/Tyrp1b/J
000623   TR/DiEiJ
View Strains carrying   a     (102 strains)

Strains carrying other alleles of a
003301   (C57BL/6J x C3H-Eya1bor)F1/J
000251   AEJ.Cg-ae +/a Gdf5bp-H/J
000202   AEJ/Gn-bd/J
000199   AEJ/GnLeJ
000427   B10.CE-H13b Aw/(30NX)SnJ
000420   B10.LP-H13b Aw/Sn
000477   B10.PA-Pldnpa H3e at/SnJ
000419   B10.UW-H3b we Pax1un at/SnJ
000593   B6 x B6CBCa Aw-J/A-Grid2Lc T(2;6)7Ca MitfMi-wh/J
000502   B6 x B6CBCa Aw-J/A-Myo5aflr Gnb5flr/J
000599   B6 x B6CBCa Aw-J/A-T(5;13)264Ca KitW-v/J
002083   B6 x B6EiC3 a/A-T(7;16)235Dn/J
000507   B6 x B6EiC3 a/A-Otcspf/J
002016   B6(Cg)-Aw-J EdaTa-6J Chr YB6-Sxr/EiJ
000552   B6-Aw-J-EdaTa-6J.Cg-Sxr
001730   B6-Aw-J-EdaTa-6J.Cg-Sxrb Hya-/J
000841   B6-Aw-J.CBy-EdaTa-By/J
001809   B6-Aw-J.Cg-EdaTa-6J +/+ ArTfm/J
000600   B6-Gpi1b x B6CBCa Aw-J/A-T(7;15)9H Gpi1a/J
000769   B6.C/(HZ18)By-at-44J/J
000203   B6.C3-Aiy/a/J
000017   B6.C3Fe-Avy/J
000628   B6.CE-A Amy1b Amy2b/J
005505   B6.Cg-Ay Slc7a11sut/LmLlp
000021   B6.Cg-Ay/J
001572   B6.Cg-am-J/J
100409   B6129PF1/J-Aw-J/Aw
004200   B6;CBACa Aw-J/A-Npr2cn-2J/J
000505   B6C3 Aw-J/A-Mutedmu/J
000604   B6C3 a/A-T(10;13)199H +/+ Lystbg-J/J or Lystbg-2J/J
000065   B6C3Fe a/a-we Pax1un at/J
000314   B6CBACa Aw-J/A-EdaTa/J-XO
000501   B6CBACa Aw-J/A-Aifm1Hq/J
001046   B6CBACa Aw-J/A-Grid2Lc/J
000500   B6CBACa Aw-J/A-Gs/J
002703   B6CBACa Aw-J/A-Hydinhy3/J
000247   B6CBACa Aw-J/A-Kcnj6wv/J
000287   B6CBACa Aw-J/A-Plp1jp EdaTa/J
000515   B6CBACa Aw-J/A-SfnEr/J
000242   B6CBACa Aw-J/A-spc/J
000288   B6CBACa Aw-J/A-we a Mafbkr/J
001201   B6CBACaF1/J-Aw-J/A
001752   B6CBCa Aw-J/A-T(7;15)9H/J
006450   B6EiC3 a/A-Vss/J
000557   B6EiC3-+ a/LnpUl A/J
000504   B6EiC3Sn a/A-Cacnb4lh/J
000553   B6EiC3Sn a/A-Egfrwa2 Wnt3avt/J
001811   B6EiC3Sn a/A-Otcspf-ash/J
002343   B6EiC3Sn a/A-Otcspf/J
001923   B6EiC3Sn a/A-Ts(417)2Lws Tim/J
000200   C3FeB6 A/Aw-J-Ankank/J
000638   C3FeB6 A/Aw-J-Spnb4qv-J/J
001203   C3FeB6F1/J A/Aw-J
001272   C3H/HeSnJ-Ahvy/J
000099   C3HeB/FeJ-Avy/J
000338   C57BL/6J Aw-J-EdaTa-6J/J
000258   C57BL/6J-Ai/a/J
000774   C57BL/6J-Asy/a/J
000569   C57BL/6J-Aw-J-EdaTa +/+ ArTfm/J
000051   C57BL/6J-Aw-J/J
000055   C57BL/6J-at-33J/J
000070   C57BL/6J-atd/J
002468   KK.Cg-Ay/J
000262   LS/LeJ
000283   LT.CAST-A/J
001759   STOCK A Tyrc Sha/J
001427   STOCK Aw us/J
View Strains carrying other alleles of a     (67 strains)

Animal Health Reports

Room Number           FGB29

Research Applications

This mouse can be used to support research in many areas including:

Pax6Sey-Dey related

Developmental Biology Research
Neurodevelopmental Defects

Mouse/Human Gene Homologs
aniridia type II

Neurobiology Research
Neurodevelopmental Defects

Sensorineural Research
Cataracts (cortical)
Eye Defects

References

Additional References

Price and Supply Information

Strain Name: B6EiC3Sn a/A-Pax6Sey-Dey/J
Stock Number: 000391

Price Details

IMPORTANT NOTE: Prices are based on shipping destination. The shipping destinations are:

*Pricing for Shipping Destination selected:

        USA, Canada and Mexico

Price(s) in US dollars ($)Genotype(s) Provided
Individual Mouse Price $124.20Heterozygous for Pax6Sey-Dey
Pair $215.60B6EiC3SnF1/J (001875) x Heterozygous for Pax6Sey-Dey

Supply Details

Standard SupplyRepository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of ~nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within 48 hours of order placement.
Supply Notes Histology and Tissue Collection Services are available for all JAX® Mice strains. For more information, please contact Customer Service at orderquest@jax.org or 1-800-422-6423.
Usually shipped between four and eight weeks of age.
This strain is included in the Mouse Mutant Resource collection.
Genomic DNA is available for this strain from the Mouse DNA Resource.
LicensingSee General Terms and Conditions below  
Control InformationView Control Information in Strain Details.
View Control Pricing Information for JAX® Strains.

General Terms and Conditions

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The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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