Strain Name:

B10ScSn.Cg-T/J

Stock Number:

000405

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Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Former Names C57BL/10ScSn-T/J    (Changed: 13-MAR-08 )
Type Congenic; Mutant Strain; Spontaneous Mutation;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Additional information on Congenic nomenclature.
Specieslaboratory mouse
GenerationN18p
Generation Definitions

Related Strains

View Strains carrying   T     (4 strains)

Strains carrying other alleles of T
003879   B10;TFLe-a/a T tf/+ tf/J
004591   B6 x B6Ei.Cg-TWis/EiJ
000953   B6 x BALB/cBy-T4J/J
001518   B6 x STOCK T tf/th45 tf/J
000567   B6.Cg-T2J +/+ Qkqk-v/J
001015   B6.Cg-T4Or/J
001054   B6.Cg-TOrl/EiJ
000350   B6By.Cg-KitW-v MitfMi-wh T/J
016926   BTBR T+ tf-Fbxl3Ovtm/J
002282   BTBR T+ tf/J
001053   C3Sn.AK-Thp/EiJ
000545   C57BL/6J-T2J/J
001199   C57BL/6J-T5J/J
001961   C57BL/6JEi x STOCK T T(16;17)43H/+ T(16;17)43H/Ei
001814   STOCK Tc/J
View Strains carrying other alleles of T     (15 strains)

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.

T/T

        Background Not Specified
  • mortality/aging
  • complete embryonic lethality during organogenesis
    • die around E11   (MGI Ref ID J:13018)
  • embryogenesis phenotype
  • abnormal limb bud morphology   (MGI Ref ID J:11933)
    • posterior limb buds are absent as the posterior region of the body does not develop   (MGI Ref ID J:13018)
    • anterior limb buds are directed dorsad rather than ventrad   (MGI Ref ID J:13018)
  • abnormal neural tube morphology/development   (MGI Ref ID J:11933)
    • neural tube is slightly irregular at E8.5 and by E9, is markedly irregular in the posterior end; neural tube is more affected in the posterior than anterior end   (MGI Ref ID J:13018)
    • exhibit asymmetry of the neural tube in the mid-region at around E9   (MGI Ref ID J:13018)
    • neural tube sends out branches with secondary lumina and often the branch becomes larger than the primary neural tube   (MGI Ref ID J:13018)
    • in some embryos, the neural tube lumen is ruptured to the outside and is continuous with the amniotic cavity   (MGI Ref ID J:13018)
    • few cases show fusion between the neural tube and the gut in the posterior region   (MGI Ref ID J:13018)
    • abnormal folding and kinking of the neural folds at E8 that culminates in ectopic tubular epithelial structures lying ventral to the developing endogenous neural folds   (MGI Ref ID J:59271)
    • kinked neural tube   (MGI Ref ID J:59271)
  • abnormal placenta development
    • results in embryonic death at at E10.75   (MGI Ref ID J:11933)
  • abnormal primitive streak formation
    • backward growth does not occur preventing organization of the posterior axis and emergence of the allantoic placental stalk   (MGI Ref ID J:11933)
  • abnormal somite development   (MGI Ref ID J:11933)
    • somites appear normal at early stages but at later stages, they are reduced and by E10, somite tissue is almost absent   (MGI Ref ID J:13018)
  • absent notochord
    • notochord is absent, except for fragments in early stages   (MGI Ref ID J:13018)
  • caudal body truncation
    • posterior region of the body is greatly reduced at E10   (MGI Ref ID J:13018)
  • decreased embryo size   (MGI Ref ID J:13018)
    • structures posterior to the forelimb buds are not formed   (MGI Ref ID J:11933)
  • notochord degeneration   (MGI Ref ID J:11933)
  • growth/size phenotype
  • decreased embryo size   (MGI Ref ID J:13018)
    • structures posterior to the forelimb buds are not formed   (MGI Ref ID J:11933)
  • cardiovascular system phenotype
  • abnormal dorsal aorta morphology
    • one of the two dorsal arotae is obliterated by a diverticulum from the neural tube   (MGI Ref ID J:13018)
  • abnormal heart development
    • heart development is sometimes retarded   (MGI Ref ID J:13018)
  • abnormal pericardium morphology
    • commonly, the pericardial cavity is enlarged and is often filled with blood at E10   (MGI Ref ID J:13018)
  • hemorrhage
    • E10 homozygotes contain numerous blood-filled sinuses in the posterior end   (MGI Ref ID J:13018)
    • pericardial cavity is often filled with blood at E10   (MGI Ref ID J:13018)
  • craniofacial phenotype
  • abnormal head shape
    • in a few cases, the head region, particularly the mouth, is malformed   (MGI Ref ID J:13018)
  • limbs/digits/tail phenotype
  • abnormal limb bud morphology   (MGI Ref ID J:11933)
    • posterior limb buds are absent as the posterior region of the body does not develop   (MGI Ref ID J:13018)
    • anterior limb buds are directed dorsad rather than ventrad   (MGI Ref ID J:13018)
  • short tail   (MGI Ref ID J:13018)
  • nervous system phenotype
  • abnormal nervous system development
    • no regular segmental dorsal ganglia are formed in E10 embryos although ganglion tissue is found   (MGI Ref ID J:13018)
    • abnormal neural tube morphology/development   (MGI Ref ID J:11933)
      • neural tube is slightly irregular at E8.5 and by E9, is markedly irregular in the posterior end; neural tube is more affected in the posterior than anterior end   (MGI Ref ID J:13018)
      • exhibit asymmetry of the neural tube in the mid-region at around E9   (MGI Ref ID J:13018)
      • neural tube sends out branches with secondary lumina and often the branch becomes larger than the primary neural tube   (MGI Ref ID J:13018)
      • in some embryos, the neural tube lumen is ruptured to the outside and is continuous with the amniotic cavity   (MGI Ref ID J:13018)
      • few cases show fusion between the neural tube and the gut in the posterior region   (MGI Ref ID J:13018)
      • abnormal folding and kinking of the neural folds at E8 that culminates in ectopic tubular epithelial structures lying ventral to the developing endogenous neural folds   (MGI Ref ID J:59271)
      • kinked neural tube   (MGI Ref ID J:59271)
  • integument phenotype
  • abnormal epidermal layer morphology
    • exhibit transient blistering of the dorsal epithelium, first seen at the time of the formation of the first few somites but is completely gone by the time the embryo has attained the second flexure   (MGI Ref ID J:13018)
  • bleb
    • embryos exhibit small paired or unpaired blebs or small vesicles on either side of the mid-line at E8.5-9   (MGI Ref ID J:13018)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

T related

Developmental Biology Research
Skeletal Defects

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol T
Allele Name brachyury
Allele Type Spontaneous
Common Name(s) T1;
Strain of OriginLaboratory stock
Gene Symbol and Name T, brachyury
Chromosome 17
Gene Common Name(s) Bra; Low; Lr; T1; TFT; Tl2; Tl3; brachyury-like 2; brachyury-like 3; cou; coupe; low ratio;
Molecular Note Pulsed-field gel electrophoresis revealed an altered restriction fragment size consistent with a deletion of 160-200kb. [MGI Ref ID J:126311] [MGI Ref ID J:21263]

Genotyping

Genotyping Information


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Additional References

T related

Babiarz B; Garrisi GJ; Bennett D. 1982. Genetic analysis of the tw73 haplotype of the mouse using deletion mutations: evidence for a parasitic lethal mutation. Genet Res 39(2):111-20. [PubMed: 7084665]  [MGI Ref ID J:175674]

Bennett D. 1975. The T-locus of the mouse. Cell 6:441-454.  [MGI Ref ID J:11933]

Bucan M; Herrmann BG; Frischauf AM; Bautch VL; Bode V; Silver LM; Martin GR; Lehrach H. 1987. Deletion and duplication of DNA sequences is associated with the embryonic lethal phenotype of the t9 complementation group of the mouse t complex. Genes Dev 1(4):376-85. [PubMed: 3678828]  [MGI Ref ID J:8922]

Chesley P. 1935. Development of the short-tailed mutant in the house mouse. J Exp Zool 70:429-459.  [MGI Ref ID J:13018]

Dobrovolskaia-Zavadskaia N. 1927. Sur la mortification spontanee de la queue chez la souris nouveau-nee et sur l'existence d'un caractere (facteur) hereditaire "non-viable" C R Seances Soc Biol Fil 97:114-16.  [MGI Ref ID J:14909]

Dunn LC; Bennett D. 1971. Lethal alleles near locus T in the house mouse population on the Jutland Peninsula, Denmark Evolution 25(3):451-53.  [MGI Ref ID J:175677]

Dunn LC; Gluecksohn-Waelsch S. 1953. Genetic Analysis of Seven Newly Discovered Mutant Alleles at Locus T in the House Mouse. Genetics 38(3):261-71. [PubMed: 17247438]  [MGI Ref ID J:36683]

Fujimoto A; Baba N; Wakasugi N. 1991. A tail length modifier gene discovered in the Japanese wild mice (Mus musculus molossinus). Jpn J Genet 66(2):141-54. [PubMed: 1859671]  [MGI Ref ID J:14919]

Fujimoto A; Wakasugi N; Tomita T. 1994. The developmental and morphological studies on the neural and skeletal abnormalities in the t/btm tailless mice. Dev Growth Differ 36(4):409-417.  [MGI Ref ID J:21054]

GRUNEBERG H. 1958. Genetical studies on the skeleton of the mouse. XXIII. The development of brachyury and anury. J Embryol Exp Morphol 6(3):424-43. [PubMed: 13575656]  [MGI Ref ID J:15081]

Guenet JL; Condamine H; Gaillard J; Jacob F. 1980. twPa-1, twPa-2, twPa-3: three new t-haplotypes in the mouse. Genet Res 36(2):211-7. [PubMed: 7461454]  [MGI Ref ID J:6461]

Harrison SM; Houzelstein D; Dunwoodie SL; Beddington RS. 2000. Sp5, a new member of the Sp1 family, is dynamically expressed during development and genetically interacts with brachyury Dev Biol 227(2):358-72. [PubMed: 11071760]  [MGI Ref ID J:65743]

Herrmann BG; Labeit S; Poustka A; King TR; Lehrach H. 1990. Cloning of the T gene required in mesoderm formation in the mouse [see comments] Nature 343(6259):617-22. [PubMed: 2154694]  [MGI Ref ID J:21263]

Kinder SJ; Tsang TE; Ang SL; Behringer RR; Tam PP. 2001. Defects of the body plan of mutant embryos lacking Lim1, Otx2 or Hnf3beta activity. Int J Dev Biol 45(1 Spec No):347-55. [PubMed: 11291865]  [MGI Ref ID J:74124]

King T; Beddington RS; Brown NA. 1998. The role of the brachyury gene in heart development and left-right specification in the mouse. Mech Dev 79(1-2):29-37. [PubMed: 10349618]  [MGI Ref ID J:52218]

Le Saux F; Besson MJ; Maurin Y. 2002. Abnormal postnatal ontogeny of the locus coeruleus in the epileptic mutant mouse quaking. Brain Res Dev Brain Res 136(2):197-205. [PubMed: 12101037]  [MGI Ref ID J:109168]

Lyon MF. 1984. Transmission ratio distortion in mouse t-haplotypes is due to multiple distorter genes acting on a responder locus. Cell 37(2):621-8. [PubMed: 6722884]  [MGI Ref ID J:7443]

Lyon MF; Bechtol KB. 1977. Derivation of mutant t-haplotypes of the mouse by presumed duplication or deletion. Genet Res 30(1):63-76. [PubMed: 924142]  [MGI Ref ID J:5889]

Nadeau JH. 2001. Modifier genes in mice and humans. Nat Rev Genet 2(3):165-74. [PubMed: 11256068]  [MGI Ref ID J:88013]

Rennebeck GM; Lader E; Chen Q; Bohm RA; Cai ZS; Faust C; Magnuson T; Pease LR; Artzt K. 1995. Is there a Brachyury the Second? Analysis of a transgenic mutation involved in notochord maintenance in mice. Dev Biol 172(1):206-17. [PubMed: 7589801]  [MGI Ref ID J:29666]

Ruvinsky A; Polyakov A; Agulnik A; Tichy H; Figueroa F; Klein J. 1991. Low diversity of t haplotypes in the eastern form of the house mouse, Mus musculus L. Genetics 127(1):161-8. [PubMed: 2016041]  [MGI Ref ID J:32745]

Searle AG. 1966. Curtailed, a new dominant T-allele in the house mouse. Genet Res 7(1):86-95. [PubMed: 5906493]  [MGI Ref ID J:5003]

Silver LM; Artzt K. 1981. Recombination suppression of mouse t-haplotypes due to chromatin mismatching. Nature 290(5801):68-70. [PubMed: 7207588]  [MGI Ref ID J:6478]

Stott D; Kispert A; Herrmann BG. 1993. Rescue of the tail defect of Brachyury mice. Genes Dev 7(2):197-203. [PubMed: 8436292]  [MGI Ref ID J:3956]

Styrna J; Klein J. 1981. Evidence for two regions in the mouse t complex controlling transmission ratios. Genet Res 38(3):315-25. [PubMed: 7333459]  [MGI Ref ID J:6700]

Vojtiskova M; Viklicky V; Voracova B; Lewis SE; Gluecksohn-Waelsch S. 1976. The effects of a t-allele (tAE5) in the mouse on the lymphoid system and reproduction. J Embryol Exp Morphol 36(2):443-51. [PubMed: 1003081]  [MGI Ref ID J:83862]

Wittler L; Shin EH; Grote P; Kispert A; Beckers A; Gossler A; Werber M; Herrmann BG. 2007. Expression of Msgn1 in the presomitic mesoderm is controlled by synergism of WNT signalling and Tbx6. EMBO Rep 8(8):784-9. [PubMed: 17668009]  [MGI Ref ID J:129900]

Wu JI; Centilli MA; Vasquez G; Young S; Scolnick J; Durfee LA; Spearow JL; Schwantz SD; Rennebeck G; Artzt K. 2007. tint Maps to Mouse Chromosome 6 and May Interact With a Notochordal Enhancer of Brachyury. Genetics 177(2):1151-61. [PubMed: 17954925]  [MGI Ref ID J:126311]

Yamaguchi TP; Takada S; Yoshikawa Y; Wu N; McMahon AP. 1999. T (Brachyury) is a direct target of Wnt3a during paraxial mesoderm specification. Genes Dev 13(24):3185-90. [PubMed: 10617567]  [MGI Ref ID J:59271]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, RG10/RG30.

Purchasing information

Pricing, Supply Level & Notes, Controls


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Order this mouse

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $1980.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information.

Supply Notes

  • Cryorecovery - Standard.
    We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. The total number of animals provided, their gender and genotype will vary. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 13 and 16 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
    Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

Pricing for International shipping destinations View USA Canada and Mexico Pricing
Order this mouse

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $2574.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information.

Supply Notes

  • Cryorecovery - Standard.
    We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. The total number of animals provided, their gender and genotype will vary. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 13 and 16 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
    Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information.

General Supply Notes

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