|This C57BL/6J congenic strain is useful because it carries the T lymphocyte specific Thy1a (Thy1.1) allele. Donor T cells can be easily distinguished from recipient T cells by both flow cytometric and histological analysis using appropriate antibodies.|
Type Congenic; Mutant Strain; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Mating System Sibling x Sibling (Female x Male) 01-MAR-06 Breeding Considerations This strain is a challenging breeder. Species laboratory mouse Background Strain C57BL/6J Donor Strain PL/J Generation N11F127 (17-SEP-12)
Donating Investigator Dr. Marianna Cherry, JAX
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Related Genotype: a/a
This C57BL/6J congenic strain is useful because it carries the T lymphocyte specific Thy1a (Thy1.1) allele. Donor T cells can be easily distinguished from recipient T cells by both flow cytometric and histological analysis using appropriate antibodies.
This congenic strain was generated by Evie Sargent in the laboratory of Dr. Marianna Cherry at The Jackson Laboratory beginning sometime between 1968 and 1972. The Thy1 allele from PL/J was bred onto C57BL/6J at The Jackson Laboratory until backcross generation N10 and this strain was then maintained by sibling intercrossing homozygotes.
|Considerations for Choosing Controls|
Strains carrying Thy1a allele
005895 B10.Cg-Thy1a H2d Tg(TcraCl1,TcrbCl1)1Shrm/J 001317 B6.Cg-Gpi1a Thy1a Igha/J 022073 B6.Cg-Rag1tm1Mom Thy1a Tg(Tcra2C,Tcrb2C)1Dlo/J 014550 B6.Cg-Thy1a Tg(TcraCWM5,TcrbCWM5)1807Wuth/J 005023 B6.Cg-Thy1a/Cy Tg(TcraTcrb)8Rest/J 000983 B6.PL/(84NS)CyJ 017351 BKa.Cg-Ptprcb Bmi1tm1Ilw Thy1a/J 007687 BKa.Cg-Sox17tm1Sjm Ptprcb Thy1a/J 007686 BKa.Cg-Sox17tm2Sjm Ptprcb Thy1a/J 005307 CBy.Cg-Thy1a Tg(TcraCl4,TcrbCl4)1Shrm/ShrmJ 005922 CBy.Cg-Thy1a Tg(TcraCl1,TcrbCl1)1Shrm/J 005443 CBy.PL(B6)-Thy1a/ScrJ 005686 NOD.Cg-Thy1a Tg(TcraCl4,TcrbCl4)1Shrm/ShrmJ 004483 NOD.NON-Thy1a/1LtJ 002721 NOD.NON-Thy1a/J 005651 SJL.AK-Thy1a/TseJ 003961 SJL.Cg Thy1a-Noxo1hslt/JView Strains carrying Thy1a (17 strains)Strains carrying other alleles of Thy1
017798 B6.Cg-Mapttm1Hnd Tg(Thy1-MAPT*)3610Gds/Mmjax 009126 B6.Cg-Nos2tm1Lau Tg(Thy1-APPSwDutIowa)BWevn/Mmjax 008730 B6.Cg-Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/Mmjax 007901 B6.Cg-Tg(Thy1-Brainbow1.0)HLich/J 007911 B6.Cg-Tg(Thy1-Brainbow1.1)MLich/J 007921 B6.Cg-Tg(Thy1-Brainbow2.1)RLich/J 003710 B6.Cg-Tg(Thy1-CFP)23Jrs/J 014131 B6.Cg-Tg(Thy1-CFP)IJrs/GfngJ 007940 B6.Cg-Tg(Thy1-CFP/COX8A)C1Lich/J 007967 B6.Cg-Tg(Thy1-CFP/COX8A)S2Lich/J 012597 B6.Cg-Tg(Thy1-COL25A1)861Yfu/J 007612 B6.Cg-Tg(Thy1-COP4/EYFP)18Gfng/J 007615 B6.Cg-Tg(Thy1-COP4/EYFP)9Gfng/J 013161 B6.Cg-Tg(Thy1-Clomeleon)1Gjau/J 007919 B6.Cg-Tg(Thy1-EGFP)OJrs/GfngJ 005630 B6.Cg-Tg(Thy1-EYFP)15Jrs/J 009611 B6.Cg-Tg(Thy1-Nlgn1)6Hnes/J 009612 B6.Cg-Tg(Thy1-Nlgn2)6Hnes/J 021069 B6.Cg-Tg(Thy1-PA-GFP)5Rmpl/J 021070 B6.Cg-Tg(Thy1-PA-GFP)6Rmpl/J 003709 B6.Cg-Tg(Thy1-YFP)16Jrs/J 003782 B6.Cg-Tg(Thy1-YFP)HJrs/J 005627 B6.Cg-Tg(Thy1-YFP/Syp)10Jrs/J 007606 B6.Cg-Tg(Thy1-cre/ERT2,-EYFP)AGfng/J 004807 B6;129-Psen1tm1Mpm Tg(APPSwe,tauP301L)1Lfa/Mmjax 007910 B6;CBA-Tg(Thy1-Brainbow1.0)LLich/J 011070 B6;CBA-Tg(Thy1-EGFP)SJrs/NdivJ 017892 B6;CBA-Tg(Thy1-GCaMP2.2c)8Gfng/J 017893 B6;CBA-Tg(Thy1-GCaMP3)6Gfng/J 014130 B6;CBA-Tg(Thy1-YFP)GJrs/GfngJ 014651 B6;CBA-Tg(Thy1-spH)21Vnmu/J 015814 B6;CBA-Tg(Thy1-spH)64Vnmu/FrkJ 012341 B6;SJL-Tg(Thy1-COP3/EYFP)1Gfng/J 012344 B6;SJL-Tg(Thy1-COP3/EYFP)4Gfng/J 012348 B6;SJL-Tg(Thy1-COP3/EYFP)8Gfng/J 012350 B6;SJL-Tg(Thy1-COP4*H134R/EYFP)20Gfng/J 008004 B6;SJL-Tg(Thy1-ECFP/VAMP2)1Sud/J 012836 B6;SJL-Tg(Thy1-TARDBP)4Singh/J 007610 B6;SJL-Tg(Thy1-cre/ERT2,-EYFP)VGfng/J 012332 B6;SJL-Tg(Thy1-hop/EYFP)2Gfng/J 012334 B6;SJL-Tg(Thy1-hop/EYFP)4Gfng/J 006554 B6SJL-Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/Mmjax 017590 B6SJL-Tg(Thy1-DCTN1*G59S)M2Pcw/J 007880 B6SJL-Tg(Thy1-Stx1a/EYFP)1Sud/J 007856 B6SJL-Tg(Thy1-Syt1/ECFP)1Sud/J 017589 B6SJL-Tg(Thy1-TARDBP*G298S)S97Pcw/J 007027 C57BL/6-Tg(Thy1-APPSwDutIowa)BWevn/Mmjax 010800 C57BL/6-Tg(Thy1-PTGS2)300Kand/J 010703 C57BL/6-Tg(Thy1-PTGS2)303Kand/J 012769 C57BL/6-Tg(Thy1-Sncg)HvP36Putt/J 024339 C57BL/6J-Tg(Thy1-GCaMP6f)GP5.11Dkim/J 024276 C57BL/6J-Tg(Thy1-GCaMP6f)GP5.5Dkim/J 024275 C57BL/6J-Tg(Thy1-GCaMP6s)GP4.3Dkim/J 016936 C57BL/6N-Tg(Thy1-SNCA)12Mjff/J 017682 C57BL/6N-Tg(Thy1-SNCA)15Mjff/J 018671 D2.Cg-Tg(Thy1-CFP)23Jrs/SjJ 008230 FVB(Cg)-Tg(Thy1-SOD1*G93A)T3Hgrd/J 006143 FVB/N-Tg(Thy1-cre)1Vln/J 021226 STOCK Tg(Thy1-Brainbow3.1)18Jrs/J 021225 STOCK Tg(Thy1-Brainbow3.1)3Jrs/J 021227 STOCK Tg(Thy1-Brainbow3.2)7Jrs/J 013162 STOCK Tg(Thy1-Clomeleon)12Gjau/J 013163 STOCK Tg(Thy1-Clomeleon)13Gjau/J 007788 STOCK Tg(Thy1-EGFP)MJrs/J 012708 STOCK Tg(Thy1-cre/ERT2,-EYFP)HGfng/PyngJView Strains carrying other alleles of Thy1 (65 strains)
View Research ApplicationsResearch ApplicationsCurrently there is no phenotype information for this strain.This mouse can be used to support research in many areas including:
Immunology, Inflammation and Autoimmunity Research
CD Antigens, Antigen Receptors, and Histocompatibility Markers
Tissue/Cell Markers: T cell specific surface marker
Immunology, Inflammation and Autoimmunity Research
T cell specific surface marker
|Allele Name||a variant|
|Allele Type||Not Applicable|
|Common Name(s)||Thy-1.1; Thy1.1; Thy1a; theta-AKR; thetaAKR;|
|Site of Expression||The Thy1 locus determines a surface antigen present on cells of the thymus, a number of mouse leukemias, brain, and in lesser amounts on lymph node and spleen cells.|
|Gene Symbol and Name||Thy1, thymus cell antigen 1, theta|
|Gene Common Name(s)||CD7; CD90; T25; Thy 1.2; Thy-1; Thy-1.2; Thy1.1; Thy1.2; theta;|
The Thy1 locus determines a surface antigen present on cells of the thymus, a number of mouse leukemias, brain, and in lesser amounts on lymph node and spleen cells. The allele Thy1a determines an antigenic specificity, Thy-1.1, found in the AKR and RF strains; the allele Thy1b determines an antigenic specificity, Thy-1.2, found in the C3HeB/Fe and many other strains (J:5243, J:5012, J:4469). The Thy1 antigen is probably present on all T lymphocytes and absent from all B lymphocytes, and it thus serves as a valuable T-cell marker (J:5243). It is very widely used in experiments designed to determine the distribution and function of T-cells. Thy1 specifies a T-cell surface glycoprotein, T25, with a molecular weight of 25 kDa (J:5707). The protein appears to be anchored in the cell membrane by a lipid that is either phosphotidylinositol or closely related to it (J:12016). Thy1 may function in the cell membrane as a signal transduction molecule (J:8333). The Thy1 locus, or possibly a gene closely linked to it, controls quantitative expression of a protein that isthe same size as Thy1 and is expressed on thymus and brain but not on lymph node and spleen cells (J:7900).
|Molecular Note||The allele Thy1a determines an antigenic specificity, Thy-1.1, found in the AKR and RF strains.|
Thy1aEnd Point, End Point Analysis
The Jackson Laboratory does not have a PCR genotyping assay for the Thy1a (Thy1.1) allele. Antibodies for Thy1a can be used with FACS.
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Animal Health ReportsRoom Number AX8
Mating System Sibling x Sibling (Female x Male) 01-MAR-06 Breeding Considerations This strain is a challenging breeder. Diet Information LabDiet® 5K54
|Pricing for USA, Canada and Mexico shipping destinations|
Level 2. Up to 100 mice. Larger quantities or custom orders arranged upon request.
|Pricing for International shipping destinations|
Level 2. Up to 100 mice. Larger quantities or custom orders arranged upon request.
|Considerations for Choosing Controls|
|Control Pricing Information for Genetically Engineered Mutant Strains.|
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