Strain Name:

B10.129P-H1b Hbbd Tyrc Ea7a/(5M)oSnJ

Stock Number:

000409

Availability:

Cryopreserved - Ready for recovery

Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Former Names B10.129P-H1b Hbbd Tyrc Ea7a (5M)/oSn    (Changed: 15-DEC-04 )
B10.129P-H1b Hbbd Tyrc Ea7a(5M)/oSn    (Changed: 15-DEC-04 )
Type Congenic; Minor Histocompatibility Congenic; Mutant Strain;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Additional information on Congenic nomenclature.
Specieslaboratory mouse
Background Strain C57BL/10Sn
Donor Strain 129P/Sn
GenerationN9 F86p

Control Information

  Control
   000666 C57BL/10SnJ
 
  Considerations for Choosing Controls

Related Strains

Strains carrying   Hbbd allele
000418   B10.129P-H1b Tyrc Hbbd/(5M)nSnJ
000432   B10.C-H1b Hbbd Tyrc/(41N)SnJ
000383   B6.C-Tyrc H1b Hbbd/ByJ
002074   B6.Cg-Gpi1a Hbbd H1b/DehJ
View Strains carrying   Hbbd     (4 strains)

Strains carrying   Tyrc allele
001017   AKXD10/TyJ
000765   AKXD13/TyJ
000954   AKXD15/TyJ
000958   AKXD16/TyJ
001093   AKXD18/TyJ
001062   AKXD21/TyJ
000947   AKXD22/TyJ
000969   AKXD24/TyJ
000777   AKXD6/TyJ
000763   AKXD9/TyJ
000418   B10.129P-H1b Tyrc Hbbd/(5M)nSnJ
000432   B10.C-H1b Hbbd Tyrc/(41N)SnJ
000383   B6.C-Tyrc H1b Hbbd/ByJ
001759   STOCK A Tyrc Sha/J
000006   STOCK Hk Tyrc/J
View Strains carrying   Tyrc     (15 strains)

Strains carrying other alleles of H1
000418   B10.129P-H1b Tyrc Hbbd/(5M)nSnJ
000432   B10.C-H1b Hbbd Tyrc/(41N)SnJ
000425   B10.D2-H1a/(58N)SnJ
000383   B6.C-Tyrc H1b Hbbd/ByJ
002074   B6.Cg-Gpi1a Hbbd H1b/DehJ
000413   C3.K-H1b/nSnJ
View Strains carrying other alleles of H1     (6 strains)

Strains carrying other alleles of Hbb
000562   B6(Cg)-Tubtub/J
002204   B6.129P2-Hbbtm1Unc/J
003250   B6;129P2-Hbbtm2Unc/J
000899   C.B6-Tyr+ Hbbs/J
000996   C57BL/6J-Hbbd3th/J
000758   C57BL/6J-Hbbp Hrrh-7J/J
003342   STOCK Hbatm1Paz Hbbtm1Tow Tg(HBA-HBBs)41Paz/J
View Strains carrying other alleles of Hbb     (7 strains)

View Strains carrying other alleles of Tyr     (31 strains)

Phenotype

Phenotype Information

View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Immunology and Inflammation Research
CD Antigens, Antigen Receptors, and Histocompatibility Markers

Hbbd related

Hematological Research
Hemoglobin Defects

Mouse/Human Gene Homologs
thalassemia, beta

Tyrc related

Dermatology Research
Color and White Spotting Defects
      oculocutaneous albinism, type I

Mouse/Human Gene Homologs
albinism, tyrosine negative

Genes & Alleles

Gene & Allele Information

 
Allele Symbol Hbbd
Allele Name d
Allele Type Not Applicable
Strain of OriginBALB/c
Gene Symbol and Name Hbb, hemoglobin beta chain complex
Chromosome 7
Gene Common Name(s) CD113t-C; beta-globin;
 
Allele Symbol Tyrc
Allele Name albino
Allele Type Spontaneous
Common Name(s) c;
Strain of Originold mutant of the mouse fancy
Gene Symbol and Name Tyr, tyrosinase
Chromosome 7
Gene Common Name(s) C; OCA1A; OCAIA; SHEP3; albino; c; skc35; skin/coat color 35;
General Note Tyrc, albino. This very old mutant was already known in Greek and Roman times. Hair and eyes are completely devoid of pigment (J:5436, J:5001, J:30725). The albino mutation affects the amount of tyrosinase, and thus of melanin, in pigment cells, but does not interfere with the production of pigment cells themselves (J:12173, J:13092). Melanocytes with melanosomes showing normal fine structure occur in the retina and hair follicles. Pigment granules are smaller and fewer than normal and completely lack melanin (J:5346, J:5001, J:30725). Tyrosinase is almost absent (J:12173).Although Tyr is the structural gene for tyrosinase, some albino mutations may affect tyrosinase enzyme regulation rather than structure (J:6611), suggesting that these mutations affect tyrosinase inhibition (J:5346), presumably via control regions of the gene. All the mutant alleles are recessive to wild-type in phenotype, but heterozygotes with wild-type produce intermediate amounts of tyrosinase (J:12173).Albino-locus mutants with lightly pigmented eyes have a reduced number of fibers of the optic nerve going to the ipsilateral lateral geniculate nucleus of the brain. This is probably a secondary effect of reduced tyrosinase activity or amount of pigment in the pigmentepithelium, since genes at other loci that reduce eye pigmentation also cause the same anomaly (J:5436, J:6064).Abnormal retinal pathways disrupted at the optic chiasm that occur in albinism can be corrected with a Tyr normal transgene (J:22320).Lipofuscin is a terminal oxidation product pigment that accumulates with age. In a cross of C57BL/6J and BALB/cJ, which differ in cardiac deposition of the pigment, this trait segregated with albinism, and is controlled by the Tyr locus (J:15460).Tyrc homozygotes do not perform as well as normal in a number of behavioral tests. It is likely that this effect is mediated, at least in part, by defective vision resulting from lack of retinal pigment (J:5470, J:5360, J:5378).
Molecular Note The specific mutation in the albino allele is a G to C transversion causing an amino acid change from cysteine to serine. This mutation introduces a DdeI enzyme restriction site. [MGI Ref ID J:10889] [MGI Ref ID J:40223]
 
Gene Symbol and Name Ea7, erythrocyte antigen 7
Chromosome UN
Gene Common Name(s) Ea-7;
 
Gene Symbol and Name H1, histocompatibility 1
Chromosome 7
Gene Common Name(s) H-1;

Genotyping

Genotyping Information

This strain will not have a genotyping protocol or one is not currently available.

Helpful Links

Genotyping resources and troubleshooting

References

References

Additional References

Hbbd related

Hempe JM; Ory-Ascani J; Hsia D. 2007. Genetic variation in mouse beta globin cysteine content modifies glutathione metabolism: implications for the use of mouse models. Exp Biol Med (Maywood) 232(3):437-44. [PubMed: 17327478]  [MGI Ref ID J:118857]

Russell ES; McFarland EC. 1974. Genetics of mouse hemoglobins. Ann N Y Acad Sci 241(0):25-38. [PubMed: 4611305]  [MGI Ref ID J:5500]

Ueda Y; Miyashita N; Imai K; Yamaguchi Y; Takamura K; Notohara M; Shiroishi T; Kawashima T; Ning L; Wang C; Wu X; Moriwaki K. 1999. Nucleotide sequences of the mouse globin beta gene cDNAs in a wild derived new haplotype Hbb(w1). Mamm Genome 10(9):879-82. [PubMed: 10441738]  [MGI Ref ID J:56833]

Tyrc related

Bharti K; Liu W; Csermely T; Bertuzzi S; Arnheiter H. 2008. Alternative promoter use in eye development: the complex role and regulation of the transcription factor MITF. Development 135(6):1169-78. [PubMed: 18272592]  [MGI Ref ID J:132153]

Chen J; Reifsnyder PC; Scheuplein F; Schott WH; Mileikovsky M; Soodeen-Karamath S; Nagy A; Dosch MH; Ellis J; Koch-Nolte F; Leiter EH. 2005. 'Agouti NOD': identification of a CBA-derived Idd locus on Chromosome 7 and its use for chimera production with NOD embryonic stem cells. Mamm Genome 16(10):775-83. [PubMed: 16261419]  [MGI Ref ID J:102639]

Coleman DL. 1962. Effect of genic substitution on the incorporation of tyrosine into the melanin of mouse skin. Arch Biochem Biophys 96:562-8. [PubMed: 13880466]  [MGI Ref ID J:12173]

Detlefsen JA. 1921. A new mutation in the house mouse Am Naturalist 55:469-73.  [MGI Ref ID J:34484]

Dickie MM. 1966. Platinum Mouse News Lett 34:30.  [MGI Ref ID J:13442]

Guillery RW. 1974. Visual pathways in albinos. Sci Am 230(5):44-54. [PubMed: 4822986]  [MGI Ref ID J:5436]

Hearing VJ; Phillips P; Lutzner MA. 1973. The fine structure of melanogenesis in coat color mutants of the mouse. J Ultrastruct Res 43(1):88-106. [PubMed: 4634048]  [MGI Ref ID J:5346]

Hegmann JP; Kieso RA; Hartman HB. 1974. Gene differences influencing visual system function and behavior. Behav Genet 4(2):165-70. [PubMed: 4842093]  [MGI Ref ID J:5470]

Jackson IJ; Bennett DC. 1990. Identification of the albino mutation of mouse tyrosinase by analysis of an in vitro revertant. Proc Natl Acad Sci U S A 87(18):7010-4. [PubMed: 2119500]  [MGI Ref ID J:40223]

Jeffery G; Schutz G; Montoliu L. 1994. Correction of abnormal retinal pathways found with albinism by introduction of a functional tyrosinase gene in transgenic mice. Dev Biol 166(2):460-4. [PubMed: 7813769]  [MGI Ref ID J:22320]

Juriloff DM; Harris MJ; Wong V; Miller JE. 1992. Studies of a spontaneous lethal mutation at the albino locus in SELH/Bc mice. Genome 35(2):342-6. [PubMed: 1618394]  [MGI Ref ID J:62]

Karst SY; Ward-Bailey PF; Smith R; Washburn L; Bergstrom D; Johnson KR; Donahue LR; Davisson MT. 2009. Chick Yellow: a new mutation on Chromosome 3 causing eye and coat color phenotypes MGI Direct Data Submission :.  [MGI Ref ID J:149273]

Mouse Genome Informatics (MGI). 2005. Information obtained from the Oak Ridge National Laboratory Mutant Mouse Database (ORNL), Oak Ridge, TN (http://bio.lsd.ornl.gov/mouse/) :.  [MGI Ref ID J:100221]

Moyer FH. 1966. Genetic variations in the fine structure and ontogeny of mouse melanin granules. Am Zool 6(1):43-66. [PubMed: 5902512]  [MGI Ref ID J:5001]

Qiao JH; Welch CL; Xie PZ; Fishbein MC; Lusis AJ. 1993. Involvement of the tyrosinase gene in the deposition of cardiac lipofuscin in mice. Association with aortic fatty streak development. J Clin Invest 92(5):2386-93. [PubMed: 8227355]  [MGI Ref ID J:15460]

Rios M; Habecker B; Sasaoka T; Eisenhofer G; Tian H; Landis S ; Chikaraishi D ; Roffler-Tarlov S. 1999. Catecholamine synthesis is mediated by tyrosinase in the absence of tyrosine hydroxylase. J Neurosci 19(9):3519-26. [PubMed: 10212311]  [MGI Ref ID J:54692]

Russell LB; Hunsicker PR; Cacheiro NL; Rinchik EM. 1992. Genetic, cytogenetic, and molecular analyses of mutations induced by melphalan demonstrate high frequencies of heritable deletions and other rearrangements from exposure of postspermatogonial stages of the mouse. Proc Natl Acad Sci U S A 89(13):6182-6. [PubMed: 1352884]  [MGI Ref ID J:24557]

SILVERS WK. 1958. Origin and identity of clear cells found in hair bulbs of albino mice. Anat Rec 130(2):135-44. [PubMed: 13545569]  [MGI Ref ID J:30725]

Silvers WK. 1956. Pigment cells: occurrence in hair follicles. J Morphol 99:41-55.  [MGI Ref ID J:13092]

Sweet HO. 1987. Acromelanic (c<a>) Mouse News Lett 78:56.  [MGI Ref ID J:14994]

Thiessen DD; Lindzey G; Owen K. 1970. Behavior and allelic variations in enzyme activity and coat color at the C locus of the mouse. Behav Genet 1(3):257-67. [PubMed: 5005683]  [MGI Ref ID J:5360]

Townsend D; Witkop CJ Jr; Mattson J. 1981. Tyrosinase subcellular distribution and kinetic parameters in wild type and C-locus mutant C57BL/6J mice. J Exp Zool 216(1):113-9. [PubMed: 6793688]  [MGI Ref ID J:6611]

Tyler PA. 1970. Coat color differences and runway learning in mice. Behav Genet 1(2):149-55. [PubMed: 5527659]  [MGI Ref ID J:5378]

Wakamatsu K; Hirobe T; Ito S. 2007. High levels of melanin-related metabolites in plasma from pink-eyed dilution mice. Pigment Cell Res 20(3):222-4. [PubMed: 17516930]  [MGI Ref ID J:148667]

Yokoyama T; Silversides DW; Waymire KG; Kwon BS; Takeuchi T; Overbeek PA. 1990. Conserved cysteine to serine mutation in tyrosinase is responsible for the classical albino mutation in laboratory mice. Nucleic Acids Res 18(24):7293-8. [PubMed: 2124349]  [MGI Ref ID J:10889]

Health & husbandry

Health & Colony Maintenance Information

Currently there no information available for this strain. This may be due to the supply level of this strain.

Purchasing information

Pricing, Supply Level & Notes, Controls, General Terms & Conditions

Pricing

Pricing for USA, Canada and Mexico shipping destinations View International pricing
Price (US dollars $)
Cryorecovery Fee $1900.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Additional Supply Details

Pricing for International shipping destinations View USA Canada and Mexico pricing
Price (US dollars $)
Cryorecovery Fee $2470.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Additional Supply Details

Supply Details

Standard SupplyCryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information.
Supply Notes
  • Cryorecovery - Standard.
    We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. The total number of animals provided, their gender and genotype will vary. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 13 and 16 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
    Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

  • Genomic DNA is available for this strain from the Mouse DNA Resource.

Control Information

  Control
   000666 C57BL/10SnJ
 
  Considerations for Choosing Controls
  USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains.
  International - Control Pricing Information for Genetically Engineered Mutant Strains.

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