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Type Minor Histocompatibility Congenic; Mutant Strain; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Species laboratory mouse Background Strain C57BL/10Sn Donor Strain UW/Le Generation N8F84p
| Control | ||
|---|---|---|
| 000666 C57BL/10SnJ | ||
| Considerations for Choosing Controls | ||
Strains carrying Pax1un allele
000065 B6C3Fe a/a-we Pax1un at/J View Strains carrying Pax1un (1 strain)
Strains carrying at allele
000477 B10.PA-Pldnpa H3e at/SnJ 000065 B6C3Fe a/a-we Pax1un at/J 000262 LS/LeJ View Strains carrying at (3 strains)
Strains carrying we allele
000065 B6C3Fe a/a-we Pax1un at/J 000288 B6CBACa Aw-J/A-we a Mafbkr/J View Strains carrying we (2 strains)
Strains carrying other alleles of H3
000433 B10.C-H3c H13? A/(28NX)SnJ 000429 B10.C-H3c/SnJ 000424 B10.KR-H3d/SnJ 000422 B10.LP-H3b H13b/(36NS)Sn 000421 B10.LP-H3b/Sn 000477 B10.PA-Pldnpa H3e at/SnJ 001286 B6.C-H3c/ByJ View Strains carrying other alleles of H3 (7 strains)
Strains carrying other alleles of a
View Strains carrying other alleles of a (176 strains)
Strains carrying other alleles of we
003656 AKR/J-we4J/J 000475 B10.129-weBkr/CyJ View Strains carrying other alleles of we (2 strains)
View Mammalian Phenotype Terms
Mammalian Phenotype Terms
assigned by genotype
The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.
Pax1un/Pax1un
B6.Cg-Pax1un
- skeleton phenotype
- abnormal cervical vertebrae morphology (MGI Ref ID J:49339)
- the ossification center of C7 is missing unlike in wild-type mice
- abnormal lumbar vertebrae morphology (MGI Ref ID J:49339)
- the ossification centers at L3 and all caudally following segments are fused to the pedicles
- duel ossification centers are found from L2 to L5 and the centrum of L4 is completely split
- abnormal rib attachment (MGI Ref ID J:49339)
- the proximal ends of the thirteenth rib pair are ossified unlike in wild-type mice
we/we
Background Not Specified
- touch/vibrissae phenotype
- curly vibrissae (MGI Ref ID J:208)
- curly whiskers are evident shortly after birth
- skin/coat/nails phenotype
- thin hair shaft (MGI Ref ID J:208)
- smaller average diameter hair shaft than normal
- waved hair (MGI Ref ID J:208)
- the coat comes in very wavy, the wave most apparent between 10 and 21 days of age, then the wave decreases with age
View Research Applications
Research Applications
This mouse can be used to support research in many areas including:
Pax1un relatedImmunology and Inflammation Research
CD Antigens, Antigen Receptors, and Histocompatibility Markers
at relatedDevelopmental Biology Research
Skeletal Defects
we relatedDermatology Research
Color and White Spotting Defects
Skin and Hair Texture Defects
| Allele Symbol | Pax1un | ||
|---|---|---|---|
| Allele Name | undulated | ||
| Allele Type | Spontaneous | ||
| Common Name(s) | un; | ||
| Strain of Origin | fancier's mice | ||
| Gene Symbol and Name | Pax1, paired box gene 1 | ||
| Chromosome | 2 | ||
| Gene Common Name(s) | HUP48; Pax-1; hbs; hunchback; un; undulated; wavy tail; wt; | ||
| Molecular Note | A point mutation results in a substitution of glycine for serine at position 15 of the paired box motifand markedly decreases the DNA-binding ability of the Pax1 protein and changes its DNA specificity. [MGI Ref ID J:9424] | ||
| Allele Symbol | at | ||
| Allele Name | black and tan | ||
| Allele Type | Spontaneous | ||
| Strain of Origin | English fancy stock | ||
| Gene Symbol and Name | a, nonagouti | ||
| Chromosome | 2 | ||
| Gene Common Name(s) | AGSW; AGTI; AGTIL; ASP; As; MGC126092; MGC126093; SHEP9; agouti; agouti signal protein; agouti suppressor; | ||
| General Note | The black and tan mutation was found by Dunn (J:15011) in a strain obtained from an English fancier. The back is black and the belly cream or yellow. Effects are recessive to A on back but dominant on belly. A/at mice resemble Aw/-.Dermal--epidermal recombination experiments have shown that the regional differences in color are determined by gene action in the dermis (J:5672).This allele is recessive to A and Aw on the dorsum and dominant to all agouti alleles on the ventrum except for Aw from which it is indistinguishable (J:78801) . | ||
| Molecular Note | This allele comprises a 6 kb insertion containing a retrovirus-like transposable element VL30 and a single 526 bp repeat into the first intron of the agouti gene at the same position as for alleles a and Aw. [MGI Ref ID J:16984] | ||
| Allele Symbol | we | ||
| Allele Name | wellhaarig | ||
| Allele Type | Spontaneous | ||
| Strain of Origin | Agnes Bluhm's stocks | ||
| Gene Symbol and Name | we, wellhaarig | ||
| Chromosome | 2 | ||
| Gene Symbol and Name | H3, histocompatibility 3 | ||
| Chromosome | 2 | ||
| Gene Common Name(s) | H-3; | ||
This strain will not have a genotyping protocol or one is not currently available.
Helpful Links
Genotyping resources and troubleshooting
Pax1un relatedat relatedAubin J; Lemieux M; Moreau J; Lapointe J; Jeannotte L. 2002. Cooperation of Hoxa5 and Pax1 Genes during Formation of the Pectoral Girdle. Dev Biol 244(1):96-113. [PubMed: 11900462] [MGI Ref ID J:75823]
Balling R; Deutsch U; Gruss P. 1988. undulated, a mutation affecting the development of the mouse skeleton, has a point mutation in the paired box of Pax 1. Cell 55(3):531-5. [PubMed: 3180219] [MGI Ref ID J:9424]
Chalepakis G; Fritsch R; Fickenscher H; Deutsch U; Goulding M; Gruss P. 1991. The molecular basis of the undulated/Pax-1 mutation. Cell 66(5):873-84. [PubMed: 1889089] [MGI Ref ID J:31264]
Dietrich S; Gruss P. 1995. undulated phenotypes suggest a role of Pax-1 for the development of vertebral and extravertebral structures. Dev Biol 167(2):529-48. [PubMed: 7875377] [MGI Ref ID J:23331]
Gruneberg H. 1950. Genetical studies on the skeleton of the mouse. II. Undulated and its "modifiers". J Genet 50:142-173. [MGI Ref ID J:13037]
Gruneberg H. 1954. Genetical studies on the skeleton of the mouse. XII. The development of undulated. J Genet 52(2):441-455. [MGI Ref ID J:13043]
Helwig U; Imai K; Schmahl W; Thomas BE; Varnum DS; Nadeau JH; Balling R. 1995. Interaction between undulated and Patch leads to an extreme form of spina bifida in double-mutant mice. Nat Genet 11(1):60-3. [PubMed: 7550316] [MGI Ref ID J:28396]
Johnson DR. 1976. The interfrontal bone and mutant genes in the mouse. J Anat 121(3):507-13. [PubMed: 1018005] [MGI Ref ID J:5776]
Joosten PH; van Zoelen EJ; Murre C. 2005. Pax1/E2a Double-Mutant Mice Develop Non-Lethal Neural Tube Defects that Resemble Human Malformations. Transgenic Res 14(6):983-7. [PubMed: 16315099] [MGI Ref ID J:103567]
Nadeau JH. 2001. Modifier genes in mice and humans. Nat Rev Genet 2(3):165-74. [PubMed: 11256068] [MGI Ref ID J:88013]
Quondamatteo F; Zieger J; Gotz W; Miosge N; Herken R. 2000. Extensive glycosylation changes revealed by lectin histochemistry in morphologically normal prenatal tissues of the mouse mutant undulated (un/un). Anat Rec 258(3):243-51. [PubMed: 10705344] [MGI Ref ID J:61387]
Timmons PM; Wallin J; Rigby PW; Balling R. 1994. Expression and function of Pax 1 during development of the pectoral girdle. Development 120(10):2773-85. [PubMed: 7607069] [MGI Ref ID J:20965]
Wilm B; Dahl E; Peters H; Balling R; Imai K. 1998. Targeted disruption of Pax1 defines its null phenotype and proves haploinsufficiency. Proc Natl Acad Sci U S A 95(15):8692-7. [PubMed: 9671740] [MGI Ref ID J:49339]
Wright ME. 1947. Undulated: a new genetic factor in Mus musculus affecting the spine and tail Heredity 1:137-41. [MGI Ref ID J:314]
we relatedBultman SJ; Klebig ML; Michaud EJ; Sweet HO; Davisson MT; Woychik RP. 1994. Molecular analysis of reverse mutations from nonagouti (a) to black-and-tan (a(t)) and white-bellied agouti (Aw) reveals alternative forms of agouti transcripts. Genes Dev 8(4):481-90. [PubMed: 8125260] [MGI Ref ID J:16984]
Candille SI; Raamsdonk CD; Chen C; Kuijper S; Chen-Tsai Y; Russ A; Meijlink F; Barsh GS. 2004. Dorsoventral patterning of the mouse coat by tbx15. PLoS Biol 2(1):E3. [PubMed: 14737183] [MGI Ref ID J:87455]
Dickie MM. 1969. Mutations at the agouti locus in the mouse. J Hered 60(1):20-5. [PubMed: 5798139] [MGI Ref ID J:30922]
Dunn LC. 1928. A Fifth Allelomorph in the Agouti Series of the House Mouse. Proc Natl Acad Sci U S A 14(10):816-9. [PubMed: 16587414] [MGI Ref ID J:15011]
Dunn LC. 1936. Studies on multiple allelomorphic series in the house mouse. I. Description of agouti and albino series of allelomorphs J Genet 33:443-53. [MGI Ref ID J:22600]
Galbraith DB; Wolff GL; Brewer NL. 1980. Hair pigment patterns in different integumental environments of the mouse. Influence of the agouti suppressor (A<s>) mutation on expression of agouti locus alleles. J Hered 71:229-234. [MGI Ref ID J:12033]
Hollander WF. 1973. a<t>/a Mouse News Lett 48:33. [MGI Ref ID J:27528]
Leamy LJ; Hrubant HE. 1971. Effects of alleles at the agouti locus on odontometric traits in the C57BL-6 strain of house mice. Genetics 67(1):87-96. [PubMed: 5556294] [MGI Ref ID J:16571]
Miller MW; Duhl DM; Vrieling H; Cordes SP; Ollmann MM; Winkes BM; Barsh GS. 1993. Cloning of the mouse agouti gene predicts a secreted protein ubiquitously expressed in mice carrying the lethal yellow mutation. Genes Dev 7(3):454-67. [PubMed: 8449404] [MGI Ref ID J:4186]
Poole TW. 1982. The agouti suppressor (As) coat color mutation in mice: developmental effects on the expression of agouti locus alleles. J Exp Zool 220(1):57-64. [PubMed: 7077265] [MGI Ref ID J:6763]
Poole TW; Silvers WK. 1976. The development of regional pigmentation patterns in black and tan (at) mice. J Exp Zool 197(1):115-9. [PubMed: 781177] [MGI Ref ID J:5672]
SILVERS WK. 1958. An experimental approach to action of genes at the agouti locus in the mouse. III. Transplants of newborn Aw-, A-and at-skin to Ay-, Aw-, A-and aa hosts. J Exp Zool 137(1):189-96. [PubMed: 13563791] [MGI Ref ID J:13013]
Sandgren K; Larsson LT; Ekelund M; Robinsson D; Ekblad E. 1998. Functional and morphological examination of ganglionic and aganglionic distal gut from the lethal spotted mouse. Eur J Pediatr Surg 8(4):234-9. [PubMed: 9783148] [MGI Ref ID J:113064]
Silvers WK. 1979. The Coat Colors of Mice; A Model for Mammalian Gene Action and Interaction. In: The Coat Colors of Mice. Springer-Verlag, New York. [MGI Ref ID J:78801]
Summerhayes IC; Franks LM. 1979. Effects of donor age on neoplastic transformation of adult mouse bladder epithelium in vitro. J Natl Cancer Inst 62(4):1017-23. [PubMed: 107359] [MGI Ref ID J:56454]
Vrieling H; Duhl DM; Millar SE; Miller KA; Barsh GS. 1994. Differences in dorsal and ventral pigmentation result from regional expression of the mouse agouti gene. Proc Natl Acad Sci U S A 91(12):5667-71. [PubMed: 8202545] [MGI Ref ID J:18750]
Wolff GL. 1978. Influence of maternal phenotype on metabolic differentiation of agouti locus mutants in the mouse. Genetics 88(3):529-39. [PubMed: 640377] [MGI Ref ID J:5964]
FALCONER DS. 1954. Linkage in the mouse: the sex-linked genes and Rough. Z Indukt Abstamm Vererbungsl 86(2):263-8. [PubMed: 13227156] [MGI Ref ID J:247]
Graff RJ; Simmons D; Meyer J; Martin-Morgan D; Kurtz M. 1986. Abnormal bone production associated with mutant mouse genes pa and we. J Hered 77(2):109-13. [PubMed: 3711636] [MGI Ref ID J:8296]
Hertwig P. 1942. Neue Mutationen und Koppelungsgruppen bei der Hausmaus Z Indukt Abstamm Vererbungsl 80:220-246. [MGI Ref ID J:208]
Koniukhov BV; Kupriianov SD. 1990. [The mutant gene wellhaarig disturbs the differentiation of hair follicle cells in the mouse] Ontogenez 21(1):56-62. [PubMed: 1694022] [MGI Ref ID J:153649]
Koniukhov BV; Malinina NA; Martynov MIu. 2004. [The we gene is a modifier of the wal gene in mice] Genetika 40(7):968-74. [PubMed: 15458208] [MGI Ref ID J:153574]
Koniukhov BV; Vsevolodov EB; Sazhina MV. 1993. [An ultrastructural analysis of the cells of the outer root sheath of the hair follicles in mice of the wellhaarig mutant strain] Ontogenez 24(1):96-102. [PubMed: 8474761] [MGI Ref ID J:153577]
Martynova MIu; Isaev DA; Koniukhov BV. 2002. [Effects of the mutant gene wellhaarig in chimeric mice] Genetika 38(11):1511-7. [PubMed: 12500677] [MGI Ref ID J:153575]
Sundberg JP (ed.). 1994. . In: Handbook of Mouse Mutations with Skin and Hair Abnormalities: Animal Models and Biomedical Tools. CRC Press, Boca Raton. [MGI Ref ID J:30359]
Colony Maintenance
Diet Information LabDiet® 5K52/5K67
| Pricing for USA, Canada and Mexico shipping destinations |
|
Animals Provided
Price (US dollars $) Cryorecovery Fee $1900.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
| Pricing for International shipping destinations |
|
Animals Provided
Price (US dollars $) Cryorecovery Fee $2470.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
| Standard Supply | Cryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information. |
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| Supply Notes |
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| Control | ||
|---|---|---|
| 000666 C57BL/10SnJ | ||
| Considerations for Choosing Controls | ||
| USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
| International - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
Purchasing Information
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Fax: 1-207-288-6150
Technical Support Email Form
| phone: | 207-288-6470 |
| fax: | 207-288-6655 |
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