Strain Name: |
B10.UW-H3b we Pax1un at/SnJ |
|---|---|
Stock Number: |
000419 |
Availability: | Repository-Cryopreserved |
General Terms and Conditions |
| Genes & Alleles | H3; Pax1; Pax1un; a; at; we; ; |
Product Information
Strain Details
Type JAX® GEMM® Strain - Minor Histocompatibility Congenic Additional information on JAX® GEMM® Strains. Type JAX® GEMM® Strain - Mutant Strain Species laboratory mouse Background Strain C57BL/10Sn Donor Strain UW/Le Generation N8F84p
Gene & Allele Details
| Allele Symbol | Pax1un | ||
|---|---|---|---|
| Allele Name | undulated | ||
| Common Name(s) | un; | ||
| Strain of Origin | fancier's mice | ||
| Gene Symbol and Name | Pax1, paired box gene 1 | ||
| Chromosome | 2 | ||
| Gene Common Name(s) | HUP48; Pax-1; hbs; hunchback; un; undulated; wavy tail; wt; | ||
| General Note | This mutation was found in mice obtained from a Cambridge, England, fancier (J:314). DNA analysis determined that the undulated mutation represented a substitution of glycine for serine at position 15 of the paired box motif in Pax1 (J:9424). This substitution markedly decreases the DNA-binding ability of the Pax1 protein and changes its DNA specificity (J:31264).Homozygotes have a shortened and usually kinked tail. The caudal vertebrae are reduced in size but not in number. The tail kinks can easily be flattened out with the fingers but immediately return when the tail is released. Some homozygotes have marked kyphosis of the lower thoracic and upper lumbar region. The vertebrae are abnormally formed over the whole spine. The acromion process of the scapula is reduced or absent (J:13037). The anomalies can be traced to the 11th day of gestation. The condensations of mesenchyme cranial to the sclerotomic fissure are smaller than normal. Instead of joining with the primitive centra in front of them to form the body of the vertebra, they remain with the material posterior to the sclerotomic fissure and enter into the intervertebral disk. The vertebrae are thus smaller and the disks larger than normal (J:13043).The double-mutant mouse homozygous for both Pax1un and patch (PdgfraPh) exhibits an extreme form of spina bifida. Neither the undulated nor the patch phenotypes are more extreme in the double mutant, and neither mutation alone has spina bifida effects (J:28396). | ||
| Molecular Note | A point mutation results in a substitution of glycine for serine at position 15 of the paired box motif. [MGI Ref ID J:9424] | ||
| Allele Symbol | at | ||
| Allele Name | black and tan | ||
| Strain of Origin | English fancy stock | ||
| Gene Symbol and Name | a, nonagouti | ||
| Chromosome | 2 | ||
| Gene Common Name(s) | AGSW; AGTI; AGTIL; ASP; As; MGC126092; MGC126093; SHEP9; agouti; agouti signal protein; agouti suppressor; | ||
| General Note | The black and tan mutation was found by Dunn (J:15011) in a strain obtained from an English fancier. The back is black and the belly cream or yellow. Effects are recessive to A on back but dominant on belly. A/at mice resemble Aw/-.Dermal--epidermal recombination experiments have shown that the regional differences in color are determined by gene action in the dermis (J:5672).This allele is recessive to A and Aw on the dorsum and dominant to all agouti alleles on the ventrum except for Aw from which it is indistinguishable (J:78801) . | ||
| Molecular Note | This allele comprises a 6 kb insertion containing a retrovirus-like transposable element VL30 and a single 526 bp repeat into the first intron of the agouti gene at the same position as for alleles a and Aw. [MGI Ref ID J:16984] | ||
| Allele Symbol | we | ||
| Allele Name | wellhaarig | ||
| Strain of Origin | Agnes Bluhm's stocks | ||
| General Note | Arose as a spontaneous mutation in the stocks of Agnes Bluhm. Homozygotes are fully fertile. They have curly whiskers at 2 to 3 days of age and a wavy first coat, most strongly evident between 10 and 21 days. In later coats the waviness is lost. The hairs have a lower average diameter then those of normal mice (J:208). we has been shown to be on Chr 2 closely linked to pallid (Pldn) and has been bred in coupling with Pldn (J:247) with no interaction between the two genes. However, Graff et al. (J:8296) reported a cross between we/we and pa/pa mice that produced F2 pallid wellhaarig offspring in much higher than expected frequency, all showing a severe skeletal abnormality and early death. The authors hypothesized that the effect was due to complementary action of genes in the pa-we segment and that the F2 pallid wellhaarig mice were pa we/pa + in genotype, accounting for the excess of this class in the F2. Why the results of this cross differed from those of similar previous crosses is not clear. | ||
| Gene Symbol and Name | H3, histocompatibility 3 | ||
| Chromosome | 2 | ||
| Gene Common Name(s) | H-3; | ||
Control Information
| Control | ||
|---|---|---|
| 000666 C57BL/10SnJ | ||
| Considerations for Choosing Controls | ||
Colony Maintenance
| Diet Information | LabDiet® 5K52/5K67 |
|---|
Related Strains
Strains carrying Pax1un allele
000065 B6C3Fe a/a-we Pax1un at/J View Strains carrying Pax1un (1 strain)
000477 B10.PA-Pldnpa H3e at/SnJ 000065 B6C3Fe a/a-we Pax1un at/J 000262 LS/LeJ
000065 B6C3Fe a/a-we Pax1un at/J 000288 B6CBACa Aw-J/A-we a Mafbkr/J
Additional Web Information
Congenic Nomenclature
Research Applications
This mouse can be used to support research in many areas including:
Pax1un relatedImmunology and Inflammation Research
CD Antigens, Antigen Receptors, and Histocompatibility Markers
at relatedDevelopmental Biology Research
Skeletal Defects
we relatedDermatology Research
Color and White Spotting Defects
Skin and Hair Texture Defects
References
Additional ReferencesPrice and Supply Information
| Strain Name: | B10.UW-H3b we Pax1un at/SnJ |
| Stock Number: | 000419 |
Price Details
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Supply Details
| Standard Supply | Repository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information. |
|---|---|
| Supply Notes |
Cryorecovery - Standard. The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two males and two females (two pairs) will be provided, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the delivery time to approximately 25 weeks. At least one member of each pair will be of known genotype and will carry the mutation if it is a mutant strain. Please note that pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Price represents a repository maintenance fee, which includes the cost of recovery of the strain from the cryopreservation resource and the periodic replacement of the frozen embryos used for recovery. Cryorecovery to establish a Dedicated Supply for greater quantities of mice. |
| Licensing | See General Terms and Conditions below |
| Control Information | View Control Information in Strain Details. |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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