| |||||||||||
Former Names B10.C-H1b Hbbd Tyrc (41N)/Sn (Changed: 15-DEC-04 ) B10.C-H1b Hbbd Tyrc(41N)/Sn (Changed: 15-DEC-04 ) Type Congenic; Minor Histocompatibility Congenic; Mutant Strain; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Species laboratory mouse Background Strain C57BL/10Sn Donor Strain BALB/c Generation N8 F89p
| Control | ||
|---|---|---|
| 000666 C57BL/10SnJ | ||
| Considerations for Choosing Controls | ||
Strains carrying Hbbd allele
000409 B10.129P-H1b Hbbd Tyrc Ea7a/(5M)oSnJ 000418 B10.129P-H1b Tyrc Hbbd/(5M)nSnJ 000383 B6.C-Tyrc H1b Hbbd/ByJ 002074 B6.Cg-Gpi1a Hbbd H1b/DehJ View Strains carrying Hbbd (4 strains)
Strains carrying Tyrc allele
001017 AKXD10/TyJ 000765 AKXD13/TyJ 000954 AKXD15/TyJ 000958 AKXD16/TyJ 001093 AKXD18/TyJ 001062 AKXD21/TyJ 000947 AKXD22/TyJ 000969 AKXD24/TyJ 000777 AKXD6/TyJ 000763 AKXD9/TyJ 000409 B10.129P-H1b Hbbd Tyrc Ea7a/(5M)oSnJ 000418 B10.129P-H1b Tyrc Hbbd/(5M)nSnJ 000383 B6.C-Tyrc H1b Hbbd/ByJ 001759 STOCK A Tyrc Sha/J 000006 STOCK Hk Tyrc/J View Strains carrying Tyrc (15 strains)
Strains carrying other alleles of H1
000409 B10.129P-H1b Hbbd Tyrc Ea7a/(5M)oSnJ 000418 B10.129P-H1b Tyrc Hbbd/(5M)nSnJ 000425 B10.D2-H1a/(58N)SnJ 000383 B6.C-Tyrc H1b Hbbd/ByJ 002074 B6.Cg-Gpi1a Hbbd H1b/DehJ 000413 C3.K-H1b/nSnJ View Strains carrying other alleles of H1 (6 strains)
Strains carrying other alleles of Hbb
000562 B6(Cg)-Tubtub/J 002204 B6.129P2-Hbbtm1Unc/J 003250 B6;129P2-Hbbtm2Unc/J 000899 C.B6-Tyr+ Hbbs/J 000996 C57BL/6J-Hbbd3th/J 000758 C57BL/6J-Hbbp Hrrh-7J/J 003342 STOCK Hbatm1Paz Hbbtm1Tow Tg(HBA-HBBs)41Paz/J View Strains carrying other alleles of Hbb (7 strains)
Strains carrying other alleles of Tyr
000090 129S1/Sv-Oca2+ Tyr+ KitlSl-J/J 000091 129T1/Sv-Oca2+ Tyrc-ch Dnd1Ter/J 001279 129T1/Sv-Oca2+ Tyrc-ch-Aft/J 005445 A.B6 Tyr+-Cybanmf333/J 005012 A.B6 Tyr+-Myo5ad-l31J/J 002565 A.B6-Tyr+/J 000580 B10.D2/nSn-Tyrc-4J/J 000822 B6 x 129S1/SvEi Oca2+ Tyr+-Vsx2or-J/J 000578 B6 x STOCK Tyrc-ch Bmp5se +/+ Myo6sv/J 000058 B6(Cg)-Tyrc-2J/J 007484 B6.Cg-Tyrc-2J Tg(Tyr)3412ARpw Tg(Sry-EGFP)92Ei/EiJ 000035 B6.Cg-Tyrc-J/J 000104 B6.Cg-Tyrc-h/J 000054 B6.D2-Tyrc-p/J 000899 C.B6-Tyr+ Hbbs/J 000339 C3H/HeJ-Tyrc-9J/J 001294 C3H/HeJ-Tyrc-a/J 001002 C57BL/10SnJ-Tyrc-11J/J 001006 CBA/J-Tyrc-10J/J 000657 CE/J 000619 FS/EiJ 004828 FVB.129P2-Pde6b+ Tyrc-ch/AntJ 007483 FVB.Cg-Tg(Tyr)3412ARpw Tg(Sry-EGFP)92Ei/EiJ 000494 J.Cg-Oca2+ Tyr+ Lystbg/J 002281 NFS.C58-Tyr+/J 004304 NOD.CBALs-Tyr+/LtJ 005115 NOD.FVB-Tg(INS-MT2A,Tyr)1Pne/PneJ 005114 NOD.FVB-Tg(Ins1-Cat,Tyr)25Pne/PneJ 000271 SH1/LeJ 000306 STOCK Dll3pu + Tyrc-ch/+ Oca2p Tyrc-ch/J 000206 STOCK a/a Tyrc-h/J View Strains carrying other alleles of Tyr (31 strains)
View Research Applications
Research Applications
This mouse can be used to support research in many areas including:
Hbbd relatedImmunology and Inflammation Research
CD Antigens, Antigen Receptors, and Histocompatibility Markers
Tyrc relatedHematological Research
Hemoglobin Defects
Mouse/Human Gene Homologs
thalassemia, beta
Dermatology Research
Color and White Spotting Defects
oculocutaneous albinism, type I
Mouse/Human Gene Homologs
albinism, tyrosine negative
| Allele Symbol | Hbbd | ||
|---|---|---|---|
| Allele Name | d | ||
| Allele Type | Not Applicable | ||
| Strain of Origin | BALB/c | ||
| Gene Symbol and Name | Hbb, hemoglobin beta chain complex | ||
| Chromosome | 7 | ||
| Gene Common Name(s) | CD113t-C; beta-globin; | ||
| Allele Symbol | Tyrc | ||
| Allele Name | albino | ||
| Allele Type | Spontaneous | ||
| Common Name(s) | c; | ||
| Strain of Origin | old mutant of the mouse fancy | ||
| Gene Symbol and Name | Tyr, tyrosinase | ||
| Chromosome | 7 | ||
| Gene Common Name(s) | C; OCA1A; OCAIA; SHEP3; albino; c; skc35; skin/coat color 35; | ||
| General Note | Tyrc, albino. This very old mutant was already known in Greek and Roman times. Hair and eyes are completely devoid of pigment (J:5436, J:5001, J:30725). The albino mutation affects the amount of tyrosinase, and thus of melanin, in pigment cells, but does not interfere with the production of pigment cells themselves (J:12173, J:13092). Melanocytes with melanosomes showing normal fine structure occur in the retina and hair follicles. Pigment granules are smaller and fewer than normal and completely lack melanin (J:5346, J:5001, J:30725). Tyrosinase is almost absent (J:12173).Although Tyr is the structural gene for tyrosinase, some albino mutations may affect tyrosinase enzyme regulation rather than structure (J:6611), suggesting that these mutations affect tyrosinase inhibition (J:5346), presumably via control regions of the gene. All the mutant alleles are recessive to wild-type in phenotype, but heterozygotes with wild-type produce intermediate amounts of tyrosinase (J:12173).Albino-locus mutants with lightly pigmented eyes have a reduced number of fibers of the optic nerve going to the ipsilateral lateral geniculate nucleus of the brain. This is probably a secondary effect of reduced tyrosinase activity or amount of pigment in the pigmentepithelium, since genes at other loci that reduce eye pigmentation also cause the same anomaly (J:5436, J:6064).Abnormal retinal pathways disrupted at the optic chiasm that occur in albinism can be corrected with a Tyr normal transgene (J:22320).Lipofuscin is a terminal oxidation product pigment that accumulates with age. In a cross of C57BL/6J and BALB/cJ, which differ in cardiac deposition of the pigment, this trait segregated with albinism, and is controlled by the Tyr locus (J:15460).Tyrc homozygotes do not perform as well as normal in a number of behavioral tests. It is likely that this effect is mediated, at least in part, by defective vision resulting from lack of retinal pigment (J:5470, J:5360, J:5378). | ||
| Molecular Note | The specific mutation in the albino allele is a G to C transversion causing an amino acid change from cysteine to serine. This mutation introduces a DdeI enzyme restriction site. [MGI Ref ID J:10889] [MGI Ref ID J:40223] | ||
| Gene Symbol and Name | H1, histocompatibility 1 | ||
| Chromosome | 7 | ||
| Gene Common Name(s) | H-1; | ||
This strain will not have a genotyping protocol or one is not currently available.
Helpful Links
Genotyping resources and troubleshooting
Hbbd relatedTyrc relatedHempe JM; Ory-Ascani J; Hsia D. 2007. Genetic variation in mouse beta globin cysteine content modifies glutathione metabolism: implications for the use of mouse models. Exp Biol Med (Maywood) 232(3):437-44. [PubMed: 17327478] [MGI Ref ID J:118857]
Russell ES; McFarland EC. 1974. Genetics of mouse hemoglobins. Ann N Y Acad Sci 241(0):25-38. [PubMed: 4611305] [MGI Ref ID J:5500]
Ueda Y; Miyashita N; Imai K; Yamaguchi Y; Takamura K; Notohara M; Shiroishi T; Kawashima T; Ning L; Wang C; Wu X; Moriwaki K. 1999. Nucleotide sequences of the mouse globin beta gene cDNAs in a wild derived new haplotype Hbb(w1). Mamm Genome 10(9):879-82. [PubMed: 10441738] [MGI Ref ID J:56833]
Bharti K; Liu W; Csermely T; Bertuzzi S; Arnheiter H. 2008. Alternative promoter use in eye development: the complex role and regulation of the transcription factor MITF. Development 135(6):1169-78. [PubMed: 18272592] [MGI Ref ID J:132153]
Chen J; Reifsnyder PC; Scheuplein F; Schott WH; Mileikovsky M; Soodeen-Karamath S; Nagy A; Dosch MH; Ellis J; Koch-Nolte F; Leiter EH. 2005. 'Agouti NOD': identification of a CBA-derived Idd locus on Chromosome 7 and its use for chimera production with NOD embryonic stem cells. Mamm Genome 16(10):775-83. [PubMed: 16261419] [MGI Ref ID J:102639]
Coleman DL. 1962. Effect of genic substitution on the incorporation of tyrosine into the melanin of mouse skin. Arch Biochem Biophys 96:562-8. [PubMed: 13880466] [MGI Ref ID J:12173]
Detlefsen JA. 1921. A new mutation in the house mouse Am Naturalist 55:469-73. [MGI Ref ID J:34484]
Dickie MM. 1966. Platinum Mouse News Lett 34:30. [MGI Ref ID J:13442]
Guillery RW. 1974. Visual pathways in albinos. Sci Am 230(5):44-54. [PubMed: 4822986] [MGI Ref ID J:5436]
Hearing VJ; Phillips P; Lutzner MA. 1973. The fine structure of melanogenesis in coat color mutants of the mouse. J Ultrastruct Res 43(1):88-106. [PubMed: 4634048] [MGI Ref ID J:5346]
Hegmann JP; Kieso RA; Hartman HB. 1974. Gene differences influencing visual system function and behavior. Behav Genet 4(2):165-70. [PubMed: 4842093] [MGI Ref ID J:5470]
Jackson IJ; Bennett DC. 1990. Identification of the albino mutation of mouse tyrosinase by analysis of an in vitro revertant. Proc Natl Acad Sci U S A 87(18):7010-4. [PubMed: 2119500] [MGI Ref ID J:40223]
Jeffery G; Schutz G; Montoliu L. 1994. Correction of abnormal retinal pathways found with albinism by introduction of a functional tyrosinase gene in transgenic mice. Dev Biol 166(2):460-4. [PubMed: 7813769] [MGI Ref ID J:22320]
Juriloff DM; Harris MJ; Wong V; Miller JE. 1992. Studies of a spontaneous lethal mutation at the albino locus in SELH/Bc mice. Genome 35(2):342-6. [PubMed: 1618394] [MGI Ref ID J:62]
Karst SY; Ward-Bailey PF; Smith R; Washburn L; Bergstrom D; Johnson KR; Donahue LR; Davisson MT. 2009. Chick Yellow: a new mutation on Chromosome 3 causing eye and coat color phenotypes MGI Direct Data Submission :. [MGI Ref ID J:149273]
Mouse Genome Informatics (MGI). 2005. Information obtained from the Oak Ridge National Laboratory Mutant Mouse Database (ORNL), Oak Ridge, TN (http://bio.lsd.ornl.gov/mouse/) :. [MGI Ref ID J:100221]
Moyer FH. 1966. Genetic variations in the fine structure and ontogeny of mouse melanin granules. Am Zool 6(1):43-66. [PubMed: 5902512] [MGI Ref ID J:5001]
Qiao JH; Welch CL; Xie PZ; Fishbein MC; Lusis AJ. 1993. Involvement of the tyrosinase gene in the deposition of cardiac lipofuscin in mice. Association with aortic fatty streak development. J Clin Invest 92(5):2386-93. [PubMed: 8227355] [MGI Ref ID J:15460]
Rios M; Habecker B; Sasaoka T; Eisenhofer G; Tian H; Landis S ; Chikaraishi D ; Roffler-Tarlov S. 1999. Catecholamine synthesis is mediated by tyrosinase in the absence of tyrosine hydroxylase. J Neurosci 19(9):3519-26. [PubMed: 10212311] [MGI Ref ID J:54692]
Russell LB; Hunsicker PR; Cacheiro NL; Rinchik EM. 1992. Genetic, cytogenetic, and molecular analyses of mutations induced by melphalan demonstrate high frequencies of heritable deletions and other rearrangements from exposure of postspermatogonial stages of the mouse. Proc Natl Acad Sci U S A 89(13):6182-6. [PubMed: 1352884] [MGI Ref ID J:24557]
SILVERS WK. 1958. Origin and identity of clear cells found in hair bulbs of albino mice. Anat Rec 130(2):135-44. [PubMed: 13545569] [MGI Ref ID J:30725]
Silvers WK. 1956. Pigment cells: occurrence in hair follicles. J Morphol 99:41-55. [MGI Ref ID J:13092]
Sweet HO. 1987. Acromelanic (c<a>) Mouse News Lett 78:56. [MGI Ref ID J:14994]
Thiessen DD; Lindzey G; Owen K. 1970. Behavior and allelic variations in enzyme activity and coat color at the C locus of the mouse. Behav Genet 1(3):257-67. [PubMed: 5005683] [MGI Ref ID J:5360]
Townsend D; Witkop CJ Jr; Mattson J. 1981. Tyrosinase subcellular distribution and kinetic parameters in wild type and C-locus mutant C57BL/6J mice. J Exp Zool 216(1):113-9. [PubMed: 6793688] [MGI Ref ID J:6611]
Tyler PA. 1970. Coat color differences and runway learning in mice. Behav Genet 1(2):149-55. [PubMed: 5527659] [MGI Ref ID J:5378]
Wakamatsu K; Hirobe T; Ito S. 2007. High levels of melanin-related metabolites in plasma from pink-eyed dilution mice. Pigment Cell Res 20(3):222-4. [PubMed: 17516930] [MGI Ref ID J:148667]
Yokoyama T; Silversides DW; Waymire KG; Kwon BS; Takeuchi T; Overbeek PA. 1990. Conserved cysteine to serine mutation in tyrosinase is responsible for the classical albino mutation in laboratory mice. Nucleic Acids Res 18(24):7293-8. [PubMed: 2124349] [MGI Ref ID J:10889]
Colony Maintenance
Diet Information LabDiet® 5K52/5K67
| Pricing for USA, Canada and Mexico shipping destinations |
|
Animals Provided
Price (US dollars $) Cryorecovery Fee $1900.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
| Pricing for International shipping destinations |
|
Animals Provided
Price (US dollars $) Cryorecovery Fee $2470.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
| Standard Supply | Cryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information. |
|---|---|
| Supply Notes |
|
| Control | ||
|---|---|---|
| 000666 C57BL/10SnJ | ||
| Considerations for Choosing Controls | ||
| USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
| International - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
Purchasing Information
JAX® Mice Orders
Surgical Services
Contact Information
Orders & Technical Support
Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
Technical Support Email Form
| phone: | 207-288-6470 |
| fax: | 207-288-6655 |
MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.
In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.
In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. In purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.
MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.
The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.
Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.