Strain Name:

C3.SW-H2b/SnJ

Stock Number:

000438

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Availability:

Level 3

Male mice from the C3.SW-H2b/SnJ congenic strain are predisposed to maturity-onset impairment of glucose tolerance and hyperinsulinemia with some mice exhibiting hyperglycemia, and they are susceptible to the diabetogenic effects of multiple low doses of streptozotocin. In addition these mice have been used in many different immunological studies.

Description

Strain Information

Type Congenic; Major Histocompatibility Congenic; Mutant Strain;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Additional information on Congenic nomenclature.
Mating SystemHomozygote x Homozygote         (Female x Male)   01-MAR-06
Breeding Considerations This strain is a good breeder.
Specieslaboratory mouse
Background Strain C3H/HeSnJ
Donor Strain Swiss Non-inbred
H2 Haplotypebc (see, Fischer Lindahl K 1997)
GenerationN11F143 (24-SEP-12)
Generation Definitions

Appearance
agouti
Related Genotype: A/A

Description
Male mice from the C3.SW-H2b/SnJ congenic strain are predisposed to maturity-onset impairment of glucose tolerance and hyperinsulinemia with some mice exhibiting hyperglycemia. Symptoms occur much later, between 5 and 8 months of age, than most of the single gene obese and diabetic strains. In addition, male mice are susceptible to the diabetogenic effects of multiple low doses of streptozotocin (40 mg/kg BW.day X 5).

Development
This strain was created, beginning in 1948, by George Snell by transferring the H2b haplotype from a mouse of an outbred Swiss stock onto the C3H/HeDiSn inbred strain by 11 rounds of backcross-intercross breeding (Snell 1958).

Control Information

  Control
   000661 C3H/HeSnJ
 
  Considerations for Choosing Controls

Related Strains

Strains carrying   H2b allele
002089   AK.B6-H2b Fv1b/J
002090   AK.B6-H2b/J
001094   AK.L-H2b/1CyTyJ
002995   B6 x C.B10-H2b/LiMcdJ-Fbn2fp-2J/J
000944   B6.SJL-H2b C3c/2CyJ
001041   BKS.B6-H2b/J
001892   BRVR.B10-H2b/J
002845   C.B-H2b Tg(H2-Dd)D8Gja/LilJ
001952   C.B10-H2b/LilMcdJ
001768   C3.Cg-Irs1Sml H2b/GrsrJ
000435   D1.LP-H2b H2-T18b?/SnJ
002591   NOD.B10Sn-H2b/J
006935   NOD.Cg-H2b thnh/J
View Strains carrying   H2b     (13 strains)

Strains carrying other alleles of H2
006500   129.NOD-(D17Mit175-H2)/J
001649   A.BY H2bc H2-T18f/SnJ-Dstncorn1/J
000140   A.BY-H2bc H2-T18f/SnJ
000472   A.CA-H2f H2-T18a/SnJ
000471   A.SW-H2s H2-T18b/SnJ
001066   A.TH-H2t2/SfDvEgMobJ
001067   A.TL-H2t1/SfDvEgMobJ
001095   AK.L-H2oz2/CyJ
001096   AK.L-H2oz3/CyJ
000470   AK.M-H2m H2-T18a/nSnJ
003851   ALR.NOD-(D17Mit30-D17Mit123)/Lt
000469   B10.A-H2a H2-T18a/SgSnJ
000468   B10.A-H2h2/(2R)SgSnJ
001150   B10.A-H2h4/(4R)SgDvEgJ
001149   B10.A-H2i3/(3R)SgDvEgJ
000467   B10.A-H2i5 H2-T18a/(5R)SgSnJ
000466   B10.AKM-H2m H2-T18a/SnJ
001954   B10.AQR-H2y1/KljMcdJ
000465   B10.BR-H2k2 H2-T18a/SgSnJ
004804   B10.BR-H2k2 H2-T18a/SgSnJJrep
005308   B10.Cg-H2d Tg(TcraCl4,TcrbCl4)1Shrm/ShrmJ
005534   B10.Cg-H2d Tg(Ins2-HA)165Bri/ShrmJ
010514   B10.Cg-H2g Tg(Cd4-Klra1)6295Dl/J
006446   B10.Cg-H2h4 Sh3pxd2bnee/GrsrJ
006102   B10.Cg-H2k Tg(Il2/NFAT-luc)83Rinc/J
006100   B10.Cg-H2k Tg(NFkB/Fos-luc)26Rinc/J
005895   B10.Cg-Thy1a H2d Tg(TcraCl1,TcrbCl1)1Shrm/J
002024   B10.D1-H2q/SgJ
001163   B10.D2-H2bm23/EgJ
000462   B10.D2-H2d/n2SnJ
001164   B10.D2-H2dm1/EgJ
001151   B10.D2-H2g3/(103R)EgJ
001153   B10.D2-H2i7/(107R)EgJ
001152   B10.D2-H2ia/(106R)EgJ
000460   B10.D2-Hc0 H2d H2-T18c/o2SnJ
000461   B10.D2-Hc0 H2d H2-T18c/oSnJ
000463   B10.D2-Hc1 H2d H2-T18c/nSnJ
003147   B10.D2-Hc1 H2d H2-T18c/nSnJ-Tg(DO11.10)10Dlo/J
000464   B10.DA-H2qp1 H2-T18b/(80NS)SnJ
001823   B10.F-H2bp5/(14R)J
001818   B10.F-H2pb1/(13R)J
001012   B10.HTG-H2g/2CyJ
000999   B10.HTG-H2g/3CyJ
001894   B10.LG-H2ar1/J
000459   B10.M-H2f H2-T18a?/SnJ
002225   B10.M-H2f/nMob Fmn1ld-2J/J
001068   B10.M-H2f/nMobJ
000739   B10.M-H2fm2/MobJ
001154   B10.MBR-H2bq1/SxEgJ
010972   B10.NOD-(rs13459151-rs13483054)/1107MrkJ
001825   B10.P-H2kp1/(10R)SgJ
003199   B10.PL-H2u H2-T18a/(73NS)Sn-Tg(TCRA)B1Jg/J
003200   B10.PL-H2u H2-T18a/(73NS)Sn-Tg(TCRB)C14Jg/J
000458   B10.PL-H2u H2-T18a/(73NS)SnJ
000457   B10.RIII-H2r H2-T18b/(71NS)SnJ
001069   B10.RIII-H2r/(71NS)nMobJ
001760   B10.S-H2as1/(8R)/J
001953   B10.S-H2s/SgMcdJ
001817   B10.S-H2sm1/(12R)SgJ
001650   B10.S-H2t4/(9R)/J
000456   B10.SM H2v H2-T18b/(70NS)Sn-cw/J
001155   B10.T-H2y2/(6R)SgDvEgJ
000445   B10.WB-H2j H2-T18b/SnJ
000444   B10.Y-H2pa H2-T18c/SnJ
003483   B6 x B10.D1-H2q/SgJ-Nox3het-2J/J
003561   B6 x B10.PL-H2u/(73NS)Sn-Hxl/J
003584   B6.129S2-H2dlAb1-Ea/J
001148   B6.AK-H2k/FlaEgJ
001895   B6.AK-H2k/J
001160   B6.C-H2bm10/KhEgJ
001161   B6.C-H2bm11/KhEgJ
000364   B6.C-H2bm2/ByJ
000369   B6.C-H2bm4/ByJ
001158   B6.C-H2bm7/KhEgJ
000360   B6.C-H2d Mdmg1BALB/cBy/aByJ
000359   B6.C-H2d/bByJ
001429   B6.C-H2g6/J
005715   B6.Cg H2g7-Tg(Ins2-CD80)3B7Flv/LwnJ
007958   B6.Cg-H2b3/FlaCmwJ
007959   B6.Cg-H2b4/FlaCmwJ
005717   B6.Cg-Sostdc1shk H2g7/GrsrJ
003068   B6.NOD-(Csf2-D11Mit42) (D17Mit21-D17Mit10)/J
004554   B6.NOD-(D17Mit21-D17Mit10) Tg(TCRaAI4)1Dvs/DvsJ
004555   B6.NOD-(D17Mit21-D17Mit10) Tg(TCRbAI4)1Dvs/DvsJ
003300   B6.NOD-(D17Mit21-D17Mit10)/LtJ
003069   B6.NOD-(D1Mit3-Bcl2) (D17Mit21-D17Mit10)/LtJ
003071   B6.NOD-(D1Mit5.1-D1Mit15) (D17Mit21-D17Mit10)/J
003067   B6.NOD-(D3Mit132-Tshb) (D17Mit21-D17Mit10)/J
003066   B6.NOD-(D6Mit54-D6Mit14) (D17Mit21-D17Mit10)/J
024949   B6.NOD-(D11Mit167) H2g7/DvsJ
025223   B6.NOD-(D11Mit167-D11Mit48) H2g7/DvsJ
000966   B6.SJL-H2s C3c/1CyJ
000945   B6.SW/1CyJ
003374   B6;129S2-H2dlAb1-Ea/J
003240   B6;B10.A-H2a-Tg(H2KmPCC)2939Stoe/J
002844   BALB.5R-H2i5/LilJ
001165   BALB/c-H2dm2/KhEgJ
001893   BRVR.D2-H2d/J
000443   C3.HTG-H2g H2-T18b?/SnJ
000441   C3.JK-H2j H2-T18b/SnJ
000440   C3.LG-H2ar1/CkcCyJ
000439   C3.NB-H2p H2-T18c?/SnJ
000473   C3H-H2o2 C4bb/SfSnJ
001156   C57BL/6J-H2bm3/EgJ
001157   C57BL/6Kh-H2bm5/KhEgJ
000437   D1.C-H2d H2-T18c/SnJ
000436   D1.DA-H2qp1/SnJ
000434   LP.RIII-H2r H2-T18b/SnJ
001383   LT.MA-Glo1b H2k/J
004447   NOD.Cg-H2h4/DilTacUmmJ
001626   NOD.NON-H2nb1/LtJ
002032   NOD.SW-H2q/J
001627   NON.NOD-H2g7/LtJ
002974   STOCK Ces1ce H2d/J
001308   STOCK H2473a/J
003154   WLC.C-H2d/MorJ
003153   WLC.Cg-H2d Mtv2a/MorJ
View Strains carrying other alleles of H2     (117 strains)

Phenotype

Phenotype Information

View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Diabetes and Obesity Research
Hyperinsulinemia
      adult onset, males
Insulin Resistance
      males

H2b related

Immunology, Inflammation and Autoimmunity Research
CD Antigens, Antigen Receptors, and Histocompatibility Markers

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol H2b
Allele Name b variant
Allele Type Not Applicable
Gene Symbol and Name H2, histocompatibility-2, MHC
Chromosome 17
Gene Common Name(s) H-2; MHC-II;
General Note The b variant has been observed in the following strains: C57BL/10, C57BL/10SnJ, BXSB/MpJ, C57BL/6J, C57L/J, LP/J, 129P3/J, 129P1/ReJ.

Genotyping

Genotyping Information

The Jackson Laboratory has not developed a genotyping protocol for H2 haplotypes. The following reference may helpful: Saha BK. J Immunol Meth 1996 Jul 17;194(1):77-83. (PMID: 8690943). Alternatively, haplotype-specific antibodies can be used with FACS.

Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Fischer Lindahl K. 1997. On naming H2 haplotypes: functional significance of MHC class Ib alleles. Immunogenetics 46(1):53-62. [PubMed: 9148789]  [MGI Ref ID J:41130]

Le PH; Leiter EH; Leyendecker JR. 1985. Genetic control of susceptibility to streptozotocin diabetes in inbred mice: effect of testosterone and H-2 haplotype. Endocrinology 116(6):2450-5. [PubMed: 3888611]  [MGI Ref ID J:109951]

Leiter EH. 1988. Control of spontaneous glucose intolerance, hyperinsulinemia, and islet hyperplasia in nonobese C3H.SW male mice by Y-linked locus and adrenal gland. Metabolism 37(7):689-96. [PubMed: 3290627]  [MGI Ref ID J:9235]

Additional References

H2b related

Arancibia-Carcamo CV; Osawa H; Arnett HA; Haskova Z; George AJ; Ono SJ; Ting JP; Streilein JW. 2004. A CIITA-independent pathway that promotes expression of endogenous rather than exogenous peptides in immune-privileged sites. Eur J Immunol 34(2):471-80. [PubMed: 14768052]  [MGI Ref ID J:115470]

Bakir HY; Tomiyama-Miyaji C; Watanabe H; Nagura T; Kawamura T; Sekikawa H; Abo T. 2006. Reasons why DBA/2 mice are resistant to malarial infection: expansion of CD3int B220+ gammadelta T cells with double-negative CD4- CD8- phenotype in the liver. Immunology 117(1):127-35. [PubMed: 16423048]  [MGI Ref ID J:106141]

Bergmann CC; Ramakrishna C; Kornacki M; Stohlman SA. 2001. Impaired T cell immunity in B cell-deficient mice following viral central nervous system infection. J Immunol 167(3):1575-83. [PubMed: 11466379]  [MGI Ref ID J:120484]

Blazar BR; Carreno BM; Panoskaltsis-Mortari A; Carter L; Iwai Y; Yagita H; Nishimura H; Taylor PA. 2003. Blockade of programmed death-1 engagement accelerates graft-versus-host disease lethality by an IFN-gamma-dependent mechanism. J Immunol 171(3):1272-7. [PubMed: 12874215]  [MGI Ref ID J:120213]

Brackertz D; Mitchell GF; Vadas MA; Mackay IR; Miller JF. 1977. Studies on antigen-induced arthritis in mice. II. Immunologic correlates of arthritis susceptibility in mice. J Immunol 118(5):1639-44. [PubMed: 300752]  [MGI Ref ID J:24641]

Buhlmann JE; Gonzalez M; Ginther B; Panoskaltsis-Mortari A; Blazar BR; Greiner DL; Rossini AA; Flavell R; Noelle RJ. 1999. Cutting edge: sustained expansion of CD8+ T cells requires CD154 expression by Th cells in acute graft versus host disease. J Immunol 162(8):4373-6. [PubMed: 10201970]  [MGI Ref ID J:119788]

Campbell IK; Hamilton JA; Wicks IP. 2000. Collagen-induced arthritis in C57BL/6 (H-2b) mice: new insights into an important disease model of rheumatoid arthritis. Eur J Immunol 30(6):1568-75. [PubMed: 10898492]  [MGI Ref ID J:62698]

Chan K; Lee DJ; Schubert A; Tang CM; Crain B; Schoenberger SP; Corr M. 2001. The roles of MHC class II, CD40, and B7 costimulation in CTL induction by plasmid DNA. J Immunol 166(5):3061-6. [PubMed: 11207256]  [MGI Ref ID J:126695]

Chapes SK; Beharka AA. 1998. Salmonella infections in the absence of the major histocompatibility complex II. J Leukoc Biol 63(3):297-304. [PubMed: 9500516]  [MGI Ref ID J:119805]

Chiang BL; Bearer E; Ansari A; Dorshkind K; Gershwin ME. 1990. The BM12 mutation and autoantibodies to dsDNA in NZB.H-2bm12 mice. J Immunol 145(1):94-101. [PubMed: 2358682]  [MGI Ref ID J:104189]

Clarke SR; Barnden M; Kurts C; Carbone FR; Miller JF; Heath WR. 2000. Characterization of the ovalbumin-specific TCR transgenic line OT-I: MHC elements for positive and negative selection. Immunol Cell Biol 78(2):110-7. [PubMed: 10762410]  [MGI Ref ID J:133645]

Clatch RJ; Melvold RW; Miller SD; Lipton HL. 1985. Theiler's murine encephalomyelitis virus (TMEV)-induced demyelinating disease in mice is influenced by the H-2D region: correlation with TEMV-specific delayed-type hypersensitivity. J Immunol 135(2):1408-14. [PubMed: 3925009]  [MGI Ref ID J:85035]

Cretin N; Bracy J; Hanson K; Iacomini J. 2002. The role of T cell help in the production of antibodies specific for Gal alpha 1-3Gal. J Immunol 168(3):1479-83. [PubMed: 11801692]  [MGI Ref ID J:112060]

Croxford AL; Akilli-Ozturk O; Rieux-Laucat F; Forster I; Waisman A; Buch T. 2008. MHC-restricted T cell receptor signaling is required for alphabeta TCR replacement of the pre T cell receptor. Eur J Immunol 38(2):391-9. [PubMed: 18203137]  [MGI Ref ID J:131357]

D'Orazio SE; Halme DG; Ploegh HL; Starnbach MN. 2003. Class Ia MHC-deficient BALB/c mice generate CD8+ T cell-mediated protective immunity against Listeria monocytogenes infection. J Immunol 171(1):291-8. [PubMed: 12817010]  [MGI Ref ID J:123815]

D'Orazio SE; Shaw CA; Starnbach MN. 2006. H2-M3-restricted CD8+ T cells are not required for MHC class Ib-restricted immunity against Listeria monocytogenes. J Exp Med 203(2):383-91. [PubMed: 16461341]  [MGI Ref ID J:118952]

Dalloul AH; Ngo K; Fung-Leung WP. 1996. CD4-negative cytotoxic T cells with a T cell receptor alpha/beta intermediate expression in CD8-deficient mice. Eur J Immunol 26(1):213-8. [PubMed: 8566069]  [MGI Ref ID J:112982]

El-Sawy T; Belperio JA; Strieter RM; Remick DG; Fairchild RL. 2005. Inhibition of polymorphonuclear leukocyte-mediated graft damage synergizes with short-term costimulatory blockade to prevent cardiac allograft rejection. Circulation 112(3):320-31. [PubMed: 15998678]  [MGI Ref ID J:117219]

Evans CF; Rall GF; Killeen N; Littman D; Oldstone MB. 1993. CD2-deficient mice generate virus-specific cytotoxic T lymphocytes upon infection with lymphocytic choriomeningitis virus. J Immunol 151(11):6259-64. [PubMed: 7902375]  [MGI Ref ID J:110661]

Feuillet V; Lucas B; Di Santo JP; Bismuth G; Trautmann A. 2005. Multiple survival signals are delivered by dendritic cells to naive CD4+ T cells. Eur J Immunol 35(9):2563-72. [PubMed: 16078277]  [MGI Ref ID J:113487]

Ford MS; Zhang ZX; Chen W; Zhang L. 2006. Double-negative T regulatory cells can develop outside the thymus and do not mature from CD8+ T cell precursors. J Immunol 177(5):2803-9. [PubMed: 16920915]  [MGI Ref ID J:139556]

Fu G; Vallee S; Rybakin V; McGuire MV; Ampudia J; Brockmeyer C; Salek M; Fallen PR; Hoerter JA; Munshi A; Huang YH; Hu J; Fox HS; Sauer K; Acuto O; Gascoigne NR. 2009. Themis controls thymocyte selection through regulation of T cell antigen receptor-mediated signaling. Nat Immunol 10(8):848-56. [PubMed: 19597499]  [MGI Ref ID J:151074]

Gerloni M; Castiglioni P; Zanetti M. 2005. The cooperation between two CD4 T cells induces tumor protective immunity in MUC.1 transgenic mice. J Immunol 175(10):6551-9. [PubMed: 16272309]  [MGI Ref ID J:119394]

Ghendler Y; Hussey RE; Witte T; Mizoguchi E; Clayton LK; Bhan AK; Koyasu S; Chang HC; Reinherz EL. 1997. Double-positive T cell receptor(high) thymocytes are resistant to peptide/major histocompatibility complex ligand-induced negative selection. Eur J Immunol 27(9):2279-89. [PubMed: 9341770]  [MGI Ref ID J:133112]

Ghendler Y; Teng MK; Liu JH; Witte T; Liu J; Kim KS; Kern P; Chang HC; Wang JH; Reinherz EL. 1998. Differential thymic selection outcomes stimulated by focal structural alteration in peptide/major histocompatibility complex ligands. Proc Natl Acad Sci U S A 95(17):10061-6. [PubMed: 9707600]  [MGI Ref ID J:119802]

Grob P; Schijns VE; van den Broek MF; Cox SP; Ackermann M; Suter M. 1999. Role of the individual interferon systems and specific immunity in mice in controlling systemic dissemination of attenuated pseudorabies virus infection. J Virol 73(6):4748-54. [PubMed: 10233935]  [MGI Ref ID J:110066]

Gubbels MR; Jorgensen TN; Metzger TE; Menze K; Steele H; Flannery SA; Rozzo SJ; Kotzin BL. 2005. Effects of MHC and gender on lupus-like autoimmunity in Nba2 congenic mice. J Immunol 175(9):6190-6. [PubMed: 16237116]  [MGI Ref ID J:119371]

Horwitz MS; Krahl T; Fine C; Lee J; Sarvetnick N. 1999. Protection from lethal coxsackievirus-induced pancreatitis by expression of gamma interferon. J Virol 73(3):1756-66. [PubMed: 9971752]  [MGI Ref ID J:120473]

Jenkinson EJ; Van Ewijk W; Owen JJ. 1981. Major histocompatibility complex antigen expression on the epithelium of the developing thymus in normal and nude mice. J Exp Med 153(2):280-92. [PubMed: 6940949]  [MGI Ref ID J:109960]

Jiang F; Yoshida T; Nakaki F; Terawaki S; Chikuma S; Kato Y; Okazaki IM; Honjo T; Okazaki T. 2009. Identification of QTLs that modify peripheral neuropathy in NOD.H2b-Pdcd1-/- mice. Int Immunol 21(5):499-509. [PubMed: 19261693]  [MGI Ref ID J:148183]

Jiang W; Anderson MS; Bronson R; Mathis D; Benoist C. 2005. Modifier loci condition autoimmunity provoked by Aire deficiency. J Exp Med 202(6):805-15. [PubMed: 16172259]  [MGI Ref ID J:107432]

Kageyama Y; Koide Y; Yoshida A; Uchijima M; Arai T; Miyamoto S; Ozeki T; Hiyoshi M; Kushida K; Inoue T. 1998. Reduced susceptibility to collagen-induced arthritis in mice deficient in IFN-gamma receptor. J Immunol 161(3):1542-8. [PubMed: 9686622]  [MGI Ref ID J:119066]

Kerkar SP; Goldszmid RS; Muranski P; Chinnasamy D; Yu Z; Reger RN; Leonardi AJ; Morgan RA; Wang E; Marincola FM; Trinchieri G; Rosenberg SA; Restifo NP. 2011. IL-12 triggers a programmatic change in dysfunctional myeloid-derived cells within mouse tumors. J Clin Invest 121(12):4746-57. [PubMed: 22056381]  [MGI Ref ID J:184027]

Klein J; Figueroa F; David CS. 1983. H-2 haplotypes, genes and antigens: second listing. II. The H-2 complex. Immunogenetics 17(6):553-96. [PubMed: 6407984]  [MGI Ref ID J:7097]

Knudsen NP; Norskov-Lauritsen S; Dolganov GM; Schoolnik GK; Lindenstrom T; Andersen P; Agger EM; Aagaard C. 2014. Tuberculosis vaccine with high predicted population coverage and compatibility with modern diagnostics. Proc Natl Acad Sci U S A 111(3):1096-101. [PubMed: 24395772]  [MGI Ref ID J:206476]

Kohlmeyer J; Cron M; Landsberg J; Bald T; Renn M; Mikus S; Bondong S; Wikasari D; Gaffal E; Hartmann G; Tuting T. 2009. Complete regression of advanced primary and metastatic mouse melanomas following combination chemoimmunotherapy. Cancer Res 69(15):6265-74. [PubMed: 19622767]  [MGI Ref ID J:150944]

Kouskoff V; Korganow AS; Duchatelle V; Degott C; Benoist C; Mathis D. 1996. Organ-specific disease provoked by systemic autoimmunity. Cell 87(5):811-22. [PubMed: 8945509]  [MGI Ref ID J:36815]

Krupnick AS; Gelman AE; Barchet W; Richardson S; Kreisel FH; Turka LA; Colonna M; Patterson GA; Kreisel D. 2005. Murine vascular endothelium activates and induces the generation of allogeneic CD4+25+Foxp3+ regulatory T cells. J Immunol 175(10):6265-70. [PubMed: 16272276]  [MGI Ref ID J:119348]

Laky K; Lewis JM; Tigelaar RE; Puddington L. 2003. Distinct requirements for IL-7 in development of TCR gamma delta cells during fetal and adult life. J Immunol 170(8):4087-94. [PubMed: 12682238]  [MGI Ref ID J:125438]

Lehmann-Grube F; Lohler J; Utermohlen O; Gegin C. 1993. Antiviral immune responses of lymphocytic choriomeningitis virus-infected mice lacking CD8+ T lymphocytes because of disruption of the beta 2-microglobulin gene. J Virol 67(1):332-9. [PubMed: 8093219]  [MGI Ref ID J:111102]

Leiter EH. 1998. NOD Mice and Related Strains: Origins, Husbandry and Biology Introduction. In: NOD Mice and Related Strains: Research Applications in Diabetes, AIDS, Cancer, and Other Diseases. RG Landes, Austin.  [MGI Ref ID J:110093]

Leng Q; Ge Q; Nguyen T; Eisen HN; Chen J. 2007. Stage-dependent reactivity of thymocytes to self-peptide--MHC complexes. Proc Natl Acad Sci U S A 104(12):5038-43. [PubMed: 17360333]  [MGI Ref ID J:120081]

Lin H; Rathmell JC; Gray GS; Thompson CB; Leiden JM; Alegre ML. 1998. Cytotoxic T lymphocyte antigen 4 (CTLA4) blockade accelerates the acute rejection of cardiac allografts in CD28-deficient mice: CTLA4 can function independently of CD28. J Exp Med 188(1):199-204. [PubMed: 9653096]  [MGI Ref ID J:115143]

Longhi MP; Sivasankar B; Omidvar N; Morgan BP; Gallimore A. 2005. Cutting edge: murine CD59a modulates antiviral CD4+ T cell activity in a complement-independent manner. J Immunol 175(11):7098-102. [PubMed: 16301611]  [MGI Ref ID J:122201]

Lucas JA; Atherly LO; Berg LJ. 2002. The absence of Itk inhibits positive selection without changing lineage commitment. J Immunol 168(12):6142-51. [PubMed: 12055226]  [MGI Ref ID J:123795]

Medema JP; de Jong J; van Hall T; Melief CJ; Offringa R. 1999. Immune escape of tumors in vivo by expression of cellular FLICE-inhibitory protein. J Exp Med 190(7):1033-8. [PubMed: 10510093]  [MGI Ref ID J:115086]

Mendiratta SK; Kovalik JP; Hong S; Singh N; Martin WD; Van Kaer L. 1999. Peptide dependency of alloreactive CD4+ T cell responses. Int Immunol 11(3):351-60. [PubMed: 10221647]  [MGI Ref ID J:110542]

Merino R; Shibata T; De Kossodo S; Izui S. 1989. Differential effect of the autoimmune Yaa and lpr genes on the acceleration of lupus-like syndrome in MRL/MpJ mice. Eur J Immunol 19(11):2131-7. [PubMed: 2599002]  [MGI Ref ID J:108759]

Miyashita N; Migita S; Moriwaki K. 1987. Effects of H-2 complex and non-H-2 background on urethane-induced chromosomal aberrations in mice. Mutat Res 176(1):59-67. [PubMed: 3099189]  [MGI Ref ID J:109945]

Mizoguchi E; Mizoguchi A; Preffer FI; Bhan AK. 2000. Regulatory role of mature B cells in a murine model of inflammatory bowel disease. Int Immunol 12(5):597-605. [PubMed: 10784605]  [MGI Ref ID J:110524]

Murphy DB. 1986. Overview: the murine MHC. In: Handbook of Experimental Immunology. Vol. 3, Genetic and Molecular Immunology. Blackwell Scientific Publ., Oxford.  [MGI Ref ID J:30731]

Nakajima H; Leonard WJ. 1999. Role of Bcl-2 in alpha beta T cell development in mice deficient in the common cytokine receptor gamma-chain: the requirement for Bcl-2 differs depending on the TCR/MHC affinity. J Immunol 162(2):782-90. [PubMed: 9916699]  [MGI Ref ID J:52019]

Nawijn MC; Piavaux BJ; Jeurink PV; Gras R; Reinders MA; Stearns T; Foote S; Hylkema MN; Groot PC; Korstanje R; Oosterhout AJ. 2011. Identification of the Mhc region as an asthma susceptibility locus in recombinant congenic mice. Am J Respir Cell Mol Biol 45(2):295-303. [PubMed: 20971879]  [MGI Ref ID J:186824]

Nguyen CQ; Gao JH; Kim H; Saban DR; Cornelius JG; Peck AB. 2007. IL-4-STAT6 signal transduction-dependent induction of the clinical phase of Sjogren's syndrome-like disease of the nonobese diabetic mouse. J Immunol 179(1):382-90. [PubMed: 17579059]  [MGI Ref ID J:149416]

Oberg L; Johansson S; Michaelsson J; Tomasello E; Vivier E; Karre K; Hoglund P. 2004. Loss or mismatch of MHC class I is sufficient to trigger NK cell-mediated rejection of resting lymphocytes in vivo - role of KARAP/DAP12-dependent and -independent pathways. Eur J Immunol 34(6):1646-53. [PubMed: 15162434]  [MGI Ref ID J:115484]

Ophir E; Or-Geva N; Gurevich I; Tal O; Eidelstein Y; Shezen E; Margalit R; Lask A; Shakhar G; Hagin D; Bachar-Lustig E; Reich-Zeliger S; Beilhack A; Negrin R; Reisner Y. 2013. Murine anti-third-party central-memory CD8(+) T cells promote hematopoietic chimerism under mild conditioning: lymph-node sequestration and deletion of anti-donor T cells. Blood 121(7):1220-8. [PubMed: 23223359]  [MGI Ref ID J:194621]

Panoskaltsis-Mortari A; Hermanson JR; Taras E; Wangensteen OD; Charo IF; Rollins BJ; Blazar BR. 2004. Post-BMT lung injury occurs independently of the expression of CCL2 or its receptor, CCR2, on host cells. Am J Physiol Lung Cell Mol Physiol 286(2):L284-92. [PubMed: 14527928]  [MGI Ref ID J:101226]

Pereira P; Zijlstra M; McMaster J; Loring JM; Jaenisch R; Tonegawa S. 1992. Blockade of transgenic gamma delta T cell development in beta 2-microglobulin deficient mice. EMBO J 11(1):25-31. [PubMed: 1531458]  [MGI Ref ID J:111105]

Peterson KE; Iwashiro M; Hasenkrug KJ; Chesebro B. 2000. Major histocompatibility complex class I gene controls the generation of gamma interferon-producing CD4(+) and CD8(+) T cells important for recovery from friend retrovirus-induced leukemia J Virol 74(11):5363-7. [PubMed: 10799615]  [MGI Ref ID J:62492]

Podolin PL; Pressey A; DeLarato NH; Fischer PA; Peterson LB; Wicker LS. 1993. I-E+ nonobese diabetic mice develop insulitis and diabetes. J Exp Med 178(3):793-803. [PubMed: 8350054]  [MGI Ref ID J:14178]

Porcellini S; Traggiai E; Schenk U; Ferrera D; Matteoli M; Lanzavecchia A; Michalak M; Grassi F. 2006. Regulation of peripheral T cell activation by calreticulin. J Exp Med 203(2):461-71. [PubMed: 16492806]  [MGI Ref ID J:119147]

Qiu H; Wang S; Yang J; Fan Y; Joyee AG; Han X; Jiao L; Yang X. 2005. Resistance to chlamydial lung infection is dependent on major histocompatibility complex as well as non-major histocompatibility complex determinants. Immunology 116(4):499-506. [PubMed: 16313363]  [MGI Ref ID J:106140]

Remer KA; Roeger B; Hambrecht C; Moll H. 2010. Natural killer cells support the induction of protective immunity during dendritic cell-mediated vaccination against Leishmania major. Immunology 131(4):570-82. [PubMed: 20673238]  [MGI Ref ID J:167103]

Rodrigues OR; Moura RA; Gomes-Pereira S; Santos-Gomes GM. 2006. H-2 complex influences cytokine gene expression in Leishmania infantum-infected macrophages. Cell Immunol 243(2):118-26. [PubMed: 17316586]  [MGI Ref ID J:120728]

Roffe E; Rothfuchs AG; Santiago HC; Marino AP; Ribeiro-Gomes FL; Eckhaus M; Antonelli LR; Murphy PM. 2012. IL-10 limits parasite burden and protects against fatal myocarditis in a mouse model of Trypanosoma cruzi infection. J Immunol 188(2):649-60. [PubMed: 22156594]  [MGI Ref ID J:180798]

Rowland SL; Leahy KF; Halverson R; Torres RM; Pelanda R. 2010. BAFF receptor signaling aids the differentiation of immature B cells into transitional B cells following tonic BCR signaling. J Immunol 185(8):4570-81. [PubMed: 20861359]  [MGI Ref ID J:164719]

Ryan CM; Schell TD. 2006. Accumulation of CD8+ T cells in advanced-stage tumors and delay of disease progression following secondary immunization against an immunorecessive epitope. J Immunol 177(1):255-67. [PubMed: 16785521]  [MGI Ref ID J:114942]

Sachs DH; Arn JS; Hansen TH. 1979. Two new recombinant H-2 haplotypes, one of which juxtaposes Kb and Ik alleles. J Immunol 123(5):1965-9. [PubMed: 114582]  [MGI Ref ID J:109962]

Santiago ML; Montano M; Benitez R; Messer RJ; Yonemoto W; Chesebro B; Hasenkrug KJ; Greene WC. 2008. Apobec3 encodes Rfv3, a gene influencing neutralizing antibody control of retrovirus infection. Science 321(5894):1343-6. [PubMed: 18772436]  [MGI Ref ID J:138778]

Sasada T; Yang Y; Lai CC; Touma M; Clayton LK; Liu JH; Parisini E; Wang JH; Reinherz EL. 2003. Disparate peptide-dependent thymic selection outcomes in beta2M-deficient mice versus TAP-1-deficient mice: implications for repertoire formation. Eur J Immunol 33(2):368-80. [PubMed: 12645934]  [MGI Ref ID J:115696]

Selin LK; Varga SM; Wong IC; Welsh RM. 1998. Protective heterologous antiviral immunity and enhanced immunopathogenesis mediated by memory T cell populations. J Exp Med 188(9):1705-15. [PubMed: 9802982]  [MGI Ref ID J:115234]

Shimamura M; Huang YY. 2002. Presence of a novel subset of NKT cells bearing an invariant V(alpha)19.1-J(alpha)26 TCR alpha chain. FEBS Lett 516(1-3):97-100. [PubMed: 11959111]  [MGI Ref ID J:109181]

Sho M; Yamada A; Najafian N; Salama AD; Harada H; Sandner SE; Sanchez-Fueyo A; Zheng XX; Strom TB; Sayegh MH. 2002. Physiological mechanisms of regulating alloimmunity: cytokines, CTLA-4, CD25+ cells, and the alloreactive T cell clone size. J Immunol 169(7):3744-51. [PubMed: 12244168]  [MGI Ref ID J:120408]

Sivasankar B; Donev RM; Longhi MP; Hughes TR; Davies R; Cole DS; Morgan BP; Marchbank KJ. 2007. CD59a deficient mice display reduced B cell activity and antibody production in response to T-dependent antigens. Mol Immunol 44(11):2978-87. [PubMed: 17296227]  [MGI Ref ID J:119703]

Skelsey ME; Mayhew E; Niederkorn JY. 2003. Splenic B cells act as antigen presenting cells for the induction of anterior chamber-associated immune deviation. Invest Ophthalmol Vis Sci 44(12):5242-51. [PubMed: 14638723]  [MGI Ref ID J:107362]

Smyth LA; Ratnasothy K; Moreau A; Alcock S; Sagoo P; Meader L; Tanriver Y; Buckland M; Lechler R; Lombardi G. 2013. Tolerogenic Donor-Derived Dendritic Cells Risk Sensitization In Vivo owing to Processing and Presentation by Recipient APCs. J Immunol 190(9):4848-60. [PubMed: 23536635]  [MGI Ref ID J:195514]

Steinhoff U; Maloy KJ; Burkhart C; Clark AJ; Rulicke T; Hengartner H; Zinkernagel RM. 1999. Variable immune response against a developmentally regulated self-antigen. J Autoimmun 12(1):27-34. [PubMed: 10028019]  [MGI Ref ID J:119612]

Sundberg J. 2007. The Jackson Aging Center MGI Direct Data Submission :.  [MGI Ref ID J:122261]

Sutton VR; Waterhouse NJ; Browne KA; Sedelies K; Ciccone A; Anthony D; Koskinen A; Mullbacher A; Trapani JA. 2007. Residual active granzyme B in cathepsin C-null lymphocytes is sufficient for perforin-dependent target cell apoptosis. J Cell Biol 176(4):425-33. [PubMed: 17283185]  [MGI Ref ID J:119725]

Svensson M; Wick MJ. 1999. Classical MHC class I peptide presentation of a bacterial fusion protein by bone marrow-derived dendritic cells. Eur J Immunol 29(1):180-8. [PubMed: 9933099]  [MGI Ref ID J:115229]

Tormo D; Ferrer A; Bosch P; Gaffal E; Basner-Tschakarjan E; Wenzel J; Tuting T. 2006. Therapeutic efficacy of antigen-specific vaccination and toll-like receptor stimulation against established transplanted and autochthonous melanoma in mice. Cancer Res 66(10):5427-35. [PubMed: 16707471]  [MGI Ref ID J:109052]

Touma M; Antonini V; Kumar M; Osborn SL; Bobenchik AM; Keskin DB; Connolly JE; Grusby MJ; Reinherz EL; Clayton LK. 2007. Functional role for I kappa BNS in T cell cytokine regulation as revealed by targeted gene disruption. J Immunol 179(3):1681-92. [PubMed: 17641034]  [MGI Ref ID J:132071]

Ueno T; Habicht A; Clarkson MR; Albin MJ; Yamaura K; Boenisch O; Popoola J; Wang Y; Yagita H; Akiba H; Ansari MJ; Yang J; Turka LA; Rothstein DM; Padera RF; Najafian N; Sayegh MH. 2008. The emerging role of T cell Ig mucin 1 in alloimmune responses in an experimental mouse transplant model. J Clin Invest 118(2):742-51. [PubMed: 18172549]  [MGI Ref ID J:131045]

Venkatesan P; Finch RG; Wakelin D. 1993. MHC haplotype influences primary Giardia muris infections in H-2 congenic strains of mice. Int J Parasitol 23(5):661-4. [PubMed: 8225770]  [MGI Ref ID J:21687]

Wang L; Han R; Lee I; Hancock AS; Xiong G; Gunn MD; Hancock WW. 2005. Permanent survival of fully MHC-mismatched islet allografts by targeting a single chemokine receptor pathway. J Immunol 175(10):6311-8. [PubMed: 16272282]  [MGI Ref ID J:119345]

Waring P; Mullbacher A. 2001. Cell death mediated by alloreactive cytotoxic T cells via the granule exocytosis or the Fas pathway is independent of p34cdc2 kinase: Fas dependent killing of cells arrested in the cell cycle. Immunol Cell Biol 79(3):264-73. [PubMed: 11380680]  [MGI Ref ID J:110426]

Wills-Karp M; Rani R; Dienger K; Lewkowich I; Fox JG; Perkins C; Lewis L; Finkelman FD; Smith DE; Bryce PJ; Kurt-Jones EA; Wang TC; Sivaprasad U; Hershey GK; Herbert DR. 2012. Trefoil factor 2 rapidly induces interleukin 33 to promote type 2 immunity during allergic asthma and hookworm infection. J Exp Med 209(3):607-22. [PubMed: 22329990]  [MGI Ref ID J:182513]

Willse A; Kwak J; Yamazaki K; Preti G; Wahl JH; Beauchamp GK. 2006. Individual odortypes: interaction of MHC and background genes. Immunogenetics 58(12):967-82. [PubMed: 17089117]  [MGI Ref ID J:116154]

Yoshida T; Jiang F; Honjo T; Okazaki T. 2008. PD-1 deficiency reveals various tissue-specific autoimmunity by H-2b and dose-dependent requirement of H-2g7 for diabetes in NOD mice. Proc Natl Acad Sci U S A 105(9):3533-8. [PubMed: 18299579]  [MGI Ref ID J:132764]

Yu G; Xu X; Vu MD; Kilpatrick ED; Li XC. 2006. NK cells promote transplant tolerance by killing donor antigen-presenting cells. J Exp Med 203(8):1851-8. [PubMed: 16864660]  [MGI Ref ID J:124395]

Zhang ZX; Yang L; Young KJ; DuTemple B; Zhang L. 2000. Identification of a previously unknown antigen-specific regulatory T cell and its mechanism of suppression. Nat Med 6(7):782-9. [PubMed: 10888927]  [MGI Ref ID J:118729]

Zosky GR; Larcombe AN; White OJ; Burchell JT; von Garnier C; Holt PG; Turner DJ; Wikstrom ME; Sly PD; Stumbles PA. 2009. Airway hyperresponsiveness is associated with activated CD4+ T cells in the airways. Am J Physiol Lung Cell Mol Physiol 297(2):L373-9. [PubMed: 19482896]  [MGI Ref ID J:151339]

Health & husbandry

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Animal Health Reports

Room Number           MP16

Colony Maintenance

Mating SystemHomozygote x Homozygote         (Female x Male)   01-MAR-06
Breeding Considerations This strain is a good breeder.

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Level 3. Up to 50 mice. Larger quantities or custom orders arranged upon request.

Supply Notes

  • Shipped at a specific age in weeks. Mice at a precise age in days, littermates and retired breeders are also available.
View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Level 3. Up to 50 mice. Larger quantities or custom orders arranged upon request.

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   000661 C3H/HeSnJ
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

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