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- Description
- Phenotype
- Genes & alleles
- Genotyping
- Health & husbandry
- References
- Purchasing information
- Terms of Use
Description
The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.
Strain Information
Former Names B10.SM-H2v H2-T18b (70NS)/Sn-cw (Changed: 15-DEC-04 ) B10.SM-H2v H2-T18b/(70NS)Sn-cw (Changed: 15-DEC-04 ) Type Congenic; Major Histocompatibility Congenic; Mutant Strain; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Species laboratory mouse Background Strain C57BL/10SnSg Donor Strain SM/J Generation N10 F79
Control Information
| Control | ||
|---|---|---|
| 000666 C57BL/10SnJ | ||
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying cw allele
000284 CWD/LeJ View Strains carrying cw (1 strain)
Phenotype
Phenotype Information
assigned by genotype
The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.
cw/cw
CBA/Cbi
- touch/vibrissae phenotype
- abnormal vibrissa morphology (MGI Ref ID J:5006)
- curly vibrissae (MGI Ref ID J:5006)
- curled vibrissae are obvious soon after birth
- pigmentation phenotype
- darkened coat color (MGI Ref ID J:5006)
- described for a CBA background
- skin/coat/nails phenotype
- abnormal coat/ hair morphology (MGI Ref ID J:5006)
cw/cw
CWD/Agl
- touch/vibrissae phenotype
- curly vibrissae (MGI Ref ID J:24875)
- easliy observed soon after birth
- tumorigenesis
- lymphoma (MGI Ref ID J:24875)
- B cell derived lymphoma (MGI Ref ID J:24875)
- this mutation is an experimental model for B-cell lymphoma
- 85% of mice develop lymphoma
- histology indicates follicular germinal center-cell lymphoma
- immunofluoresence assays demonstrate absence of thymus cell antigens
- immunofluoresence assays reveal 100% of cells are positive for surface immuoglobulin
- a leukemic blood profile is not usually associated with this lymphoma
- hematopoietic system phenotype
- abnormal spleen morphology (MGI Ref ID J:24875)
- enlarged spleen (MGI Ref ID J:24875)
- enlarged thymus (MGI Ref ID J:24875)
- less than 20% of mice develop enlarged lymphoma
- immune system phenotype
- abnormal immune system morphology (MGI Ref ID J:24875)
- abnormal lymph node morphology (MGI Ref ID J:24875)
- abnormal spleen morphology (MGI Ref ID J:24875)
- enlarged spleen (MGI Ref ID J:24875)
- enlarged thymus (MGI Ref ID J:24875)
- less than 20% of mice develop enlarged lymphoma
- life span-post-weaning/aging
- premature death (MGI Ref ID J:24875)
- mean survival time is 500 days
cw/cw+
CBA/CbiThis mouse can be used to support research in many areas including:
cw relatedImmunology and Inflammation Research
CD Antigens, Antigen Receptors, and Histocompatibility Markers
Dermatology Research
Skin and Hair Texture Defects
Genes & Alleles
Gene & Allele Information
| Allele Symbol | cw | ||
|---|---|---|---|
| Allele Name | curly whiskers | ||
| Allele Type | Spontaneous | ||
| Strain of Origin | CBA/Cbi | ||
| Gene Symbol and Name | cw, curly whiskers | ||
| Chromosome | 9 | ||
| Gene Common Name(s) | thd; | ||
| Gene Symbol and Name | H2-T18, histocompatibility 2, T region locus 18 | ||
| Chromosome | 17 | ||
| Gene Common Name(s) | H-2T18; TL Ag; Tla; thymus leukemia antigen; | ||
| Gene Symbol and Name | H2, histocompatibility-2, MHC | ||
| Chromosome | 17 | ||
| Gene Common Name(s) | H-2; MHC-II; | ||
Genotyping
Genotyping Information
This strain will not have a genotyping protocol or one is not currently available.
Helpful Links
Genotyping resources and troubleshooting
References
References
Additional References
cw relatedAngel JM; Bedigian HG. 1984. Expression of murine leukemia viruses in B-cell lymphomas of CWD/Agl mice. J Virol 52(2):691-4. [PubMed: 6092692] [MGI Ref ID J:24875]
Falconer DS; Isaacson JH. 1966. Curly-whiskers and its linkage with tail-kinks in linkage group II of the mouse. Genet Res 8(1):111-3. [PubMed: 5911159] [MGI Ref ID J:5006]
Sundberg JP (ed.). 1994. . In: Handbook of Mouse Mutations with Skin and Hair Abnormalities: Animal Models and Biomedical Tools. CRC Press, Boca Raton. [MGI Ref ID J:30359]
Health & husbandry
Health & Colony Maintenance Information
Colony Maintenance
Diet Information LabDiet® 5K52/5K67
Purchasing information
Pricing, Supply Level & Notes, Controls, General Terms & Conditions
Pricing
| Pricing for USA, Canada and Mexico shipping destinations |
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Animals Provided
Price (US dollars $) Cryorecovery Fee $1900.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Additional Supply Details
| Pricing for International shipping destinations |
|
Animals Provided
Price (US dollars $) Cryorecovery Fee $2470.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Additional Supply Details
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Supply Details
| Standard Supply | Cryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information. |
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| Supply Notes |
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Control Information
| Control | ||
|---|---|---|
| 000666 C57BL/10SnJ | ||
| Considerations for Choosing Controls | ||
| USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
| International - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
Payment Terms and Conditions
Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.
See Terms of Use tab for General Terms and Conditions
The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
Purchasing Information
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Contact Information
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Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
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| phone: | 207-288-6470 |
| fax: | 207-288-6655 |
JAX® Mice, Products & Services Conditions of Use
"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.No Warranty
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Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.