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Strain Name:

B10.RIII-H2r H2-T18b/(71NS)SnJ

Stock Number:

000457

Availability:

Level 2

Price and Supply Information

General Terms and Conditions

Former Name      B10.RIII-H2r H2-T18b (71NS)/Sn    (Changed: 15-DEC-04 )
      B10.RIII-H2r H2-T18b/(71NS)Sn    (Changed: 15-DEC-04 )
Genes & Alleles   H2-T18;   H2;   ;

Product Information

Strain Details

Type JAX® GEMM® Strain - Congenic
Additional information on JAX® GEMM® Strains.
Type JAX® GEMM® Strain - Major Histocompatibility Congenic
Type JAX® GEMM® Strain - Mutant Strain
Mating SystemSibling x Sibling         (Female x Male)
Specieslaboratory mouse
Background Strain C57BL/10Sn
Donor Strain RIII/WySn
GenerationN8F124 (03-JAN-08)

Appearance
black
Related Genotype: a/a

Strain Description
This congenic strain develops chronic and relapsing experimental autoimmune encephalomyelitis (EAE) after immunization with myelin basic protein (MBP). Susceptibility is associated with the major histocompatibility complex (MHC) allele, H2r, the T cell receptor V b8 chain, and other non MHC loci. This strain also is susceptible to induction of collagen-induced arthritis.

Gene & Allele Details

Gene Symbol and Name H2-T18, histocompatibility 2, T region locus 18
Chromosome 17
Gene Common Name(s) H-2T18; TL Ag; Tla; thymus leukemia antigen;
Gene Symbol and Name H2, histocompatibility-2, MHC
Chromosome 17
Gene Common Name(s) H-2; MHC-II;

Control Information

  Control
   000666 C57BL/10SnJ
 
  Considerations for Choosing Controls
  Control Pricing Information for JAX® GEMM® Strains

Colony Maintenance

Diet Information LabDiet® 5K52/5K67

Additional Web Information

Congenic Nomenclature
Genetic Quality Control Annual Report

Animal Health Reports

Room Number           MP15
Room Number           MP23

Research Applications

This mouse can be used to support research in many areas including:

Immunology and Inflammation Research
Autoimmunity (collagen induced arthritis)
Autoimmunity (experimental allergic encephalomyelitis (EAE))
CD Antigens, Antigen Receptors, and Histocompatibility Markers
Inflammation (collagen induced arthritis)

References

Selected Reference(s)

Blom AB; van Lent PL; Holthuysen AE; van den Berg WB. 1999. Immune complexes, but not streptococcal cell walls or zymosan, cause chronic arthritis in mouse strains susceptible for collagen type II auto-immune arthritis. Cytokine 11(12):1046-56. [PubMed: 10623430]  [MGI Ref ID J:109891]

Hankey DJ; Lightman SL; Baker D. 2001. Interphotoreceptor retinoid binding protein peptide-induced uveitis in B10.RIII mice: characterization of disease parameters and immunomodulation. Exp Eye Res 72(3):341-50. [PubMed: 11180983]  [MGI Ref ID J:68968]

Silver PB; Chan CC; Wiggert B; Caspi RR. 1999. The requirement for pertussis to induce EAU is strain-dependent: B10.RIII, but not B10.A mice, develop EAU and Th1 responses to IRBP without pertussis treatment. Invest Ophthalmol Vis Sci 40(12):2898-905. [PubMed: 10549650]  [MGI Ref ID J:58195]

Su SB; Silver PB; Zhang M; Chan CC; Caspi RR. 2001. Pertussis toxin inhibits induction of tissue-specific autoimmune disease by disrupting G protein-coupled signals. J Immunol 167(1):250-6. [PubMed: 11418656]  [MGI Ref ID J:109874]

Price and Supply Information

Strain Name: B10.RIII-H2r H2-T18b/(71NS)SnJ
Stock Number: 000457

Price Details

IMPORTANT NOTE: Prices are based on shipping destination. The shipping destinations are:

*Pricing for Shipping Destination selected:

        International

Price(s) in US dollars ($)Genotype(s) Provided
3-5 weeks $55.60Homozygous for H2r, Homozygous for H2-T18bFemale
6 weeks $58.10Homozygous for H2r, Homozygous for H2-T18bFemale
7 weeks $60.60Homozygous for H2r, Homozygous for H2-T18bFemale
8 weeks $63.10Homozygous for H2r, Homozygous for H2-T18bFemale
3-5 weeks $55.60Homozygous for H2r, Homozygous for H2-T18bMale
6 weeks $58.10Homozygous for H2r, Homozygous for H2-T18bMale
7 weeks $60.60Homozygous for H2r, Homozygous for H2-T18bMale
8 weeks $63.10Homozygous for H2r, Homozygous for H2-T18bMale

Supply Details

Standard SupplyLevel 2. Up to 100 mice. Larger quantities or custom orders arranged upon request.
Supply Notes Histology and Tissue Collection Services are available for all JAX® Mice strains. For more information, please contact Customer Service at orderquest@jax.org or 1-207-288-5845.
Shipped at a specific age in weeks. Mice at a precise age in days, littermates and retired breeders are also available.
Strains that must be genotyped are not available until five to seven weeks of age.
Genomic DNA is available for this strain from the Mouse DNA Resource.
LicensingSee General Terms and Conditions below  
Control InformationView Control Information in Strain Details.
View Control Pricing Information for JAX® Strains.

General Terms and Conditions

View JAX® Mice & Services Conditions of Use.

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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