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- Description
- Phenotype
- Genes & alleles
- Genotyping
- Health & husbandry
- References
- Purchasing information
- Terms of Use
Description
The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.
Strain Information
Type Congenic; Major Histocompatibility Congenic; Mutant Strain; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Species laboratory mouse Background Strain C57BL/10Sn Donor Strain Non-inbred Generation F92 Appearance
black
Related Genotype: a/aDescription
This congenic strain carries H2f derived from the non-inbred stock M (see development field). This strain also carries the Pgk2b allele and the Tlad allele. (Snell GD, 1958; Snell GD, 1978; Eicher et al., 1978; Flaherty et al., 1977).Development
This strain was one of George Snell's congenic resistant lines used in defining H2 alleles. The original donor strain was a non-inbred line called M which was homozygous for a and Ca and wild type for Tyrp. M was bred to C57BL/6JSn then the F1 offspring were sibling mated and the F2 mice were selected for rejection of a C57BL/6J tumor and a surviving F2 mouse was then backcrossed to C57BL/6JSn. This backcross-intercross selection protocol was continued and Snell recorded the generation number for each generation in this scheme as G#. In the 1978 text "Origins of Inbred Mice", Snell gives the generation for strain B10.M/Sn as G12F13J3F47 and the N equivalent generation as NE8F47. He adds that "Strain B10.M was originally B6.M. Subsequently two matings were made to C57BL/10, so three fourths of the background genes should be from this strain." The Jackson Laboratory has since maintained this strain by sibling breeding. Although this strain is not a full congenic on the C57BL/10 background, the name assigned by Snell, B10.M/Sn, is being maintained for historical reasons. (Snell GD, 1958; Snell GD, 1978).
Control Information
| Control | ||
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| 000666 C57BL/10SnJ | ||
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying other alleles of H2-T18
View Strains carrying other alleles of H2-T18 (33 strains)
Phenotype
Phenotype Information
This mouse can be used to support research in many areas including:
Immunology and Inflammation Research
CD Antigens, Antigen Receptors, and Histocompatibility Markers
Genes & Alleles
Gene & Allele Information
| Gene Symbol and Name | H2-T18, histocompatibility 2, T region locus 18 | ||
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| Chromosome | 17 | ||
| Gene Common Name(s) | H-2T18; TL Ag; Tla; thymus leukemia antigen; | ||
| Gene Symbol and Name | H2, histocompatibility-2, MHC | ||
| Chromosome | 17 | ||
| Gene Common Name(s) | H-2; MHC-II; | ||
Genotyping
Genotyping Information
This strain will not have a genotyping protocol or one is not currently available.
Helpful Links
Genotyping resources and troubleshooting
References
References
Additional References
Eicher EM; Cherry M; Flaherty L. 1978. Autosomal phosphoglycerate kinase linked to mouse major histocompatibility complex. Mol Gen Genet 158(3):225-8. [PubMed: 628373] [MGI Ref ID J:5942]
Flaherty L; Sullivan K; Zimmerman D. 1977. The Tla locus: a new allele and antigenic specificity. J Immunol 119(2):571-5. [PubMed: 69663] [MGI Ref ID J:5845]
Health & husbandry
Health & Colony Maintenance Information
Colony Maintenance
Diet Information LabDiet® 5K52/5K67
Purchasing information
Pricing, Supply Level & Notes, Controls, General Terms & Conditions
Pricing
| Pricing for USA, Canada and Mexico shipping destinations |
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Animals Provided
Price (US dollars $) Cryorecovery Fee $1900.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Additional Supply Details
| Pricing for International shipping destinations |
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Animals Provided
Price (US dollars $) Cryorecovery Fee $2470.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Additional Supply Details
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Supply Details
| Standard Supply | Cryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information. |
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| Supply Notes |
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Control Information
| Control | ||
|---|---|---|
| 000666 C57BL/10SnJ | ||
| Considerations for Choosing Controls | ||
| USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
| International - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
Payment Terms and Conditions
Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.
See Terms of Use tab for General Terms and Conditions
The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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Contact Information
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Tel: 1-800-422-6423 or 1-207-288-5845
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Terms of Use
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Contact information
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| phone: | 207-288-6470 |
| fax: | 207-288-6655 |
JAX® Mice, Products & Services Conditions of Use
"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.No Warranty
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The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.
Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.