JAX Mice Database - 000461 B10.D2-Hc<0> H2<d> H2-T18<c>/oSnJ

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Strain Name:	B10.D2-Hc⁰ H2^d H2-T18^c/oSnJ
Stock Number:	000461
Availability:	Level 3

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General Terms and Conditions

Former Name	B10.D2/oSnJ (Changed: 31-OCT-05 )
Genes & Alleles	H2-T18; H2; H2^d; Hc; Hc⁰; ;

Product Information

Strain Details

Type JAX^® GEMM^® Strain - Congenic

Additional information on JAX^® GEMM^® Strains.

Type JAX^® GEMM^® Strain - Major Histocompatibility Congenic

Type JAX^® GEMM^® Strain - Mutant Strain

Mating System Homozygote x Homozygote (Female x Male)

Species laboratory mouse

Background Strain C57BL/10Sn

Donor Strain DBA/2

Generation N6F106 (14-DEC-06)

Appearance
black
Related Genotype: a/a
Strain Description
This congenic strain carries the H2^d haplotype from DBA/2J following six generations of backcrossing to C57BL/10Sn. This strain still carries the Hc⁰ allele from DBA/2J, making them serum C5 deficient. Mice have increased susceptibility to certain pathogens and impaired chemotactic responses of neutrophils. Allograft rejection is prolonged. The following inbred strains are also homozygous for the Hc⁰ allele: A/HeJ (Stock No. 000645), AKR/J (Stock No. 000648), DBA/2J (Stock No. 000671), NOD/LtJ (Stock No. 001976), NZB/BlNJ (Stock No. 000684), and SWR/J (Stock No. 000689).

Mammalian Phenotype Terms assigned by genotype

The following phenotype information may relate to a genetic background differing from this JAX^® Mice strain.
Hc⁰/Hc⁰
B10.D2-Hc⁰
homeostasis/metabolism phenotype

decreased susceptibility to injury (MGI Ref ID J:120567)

mice are resistant to ischemia reperfusion-induced renal injury

serum urea nitrogen is reduced 35% to 40% compared to wild type mice subjected to ischemia reperfusion

Gene & Allele Details

Allele Symbol		H2^d
Allele Name		d variant
Gene Symbol and Name		H2, histocompatibility-2, MHC
Chromosome		17
Gene Common Name(s)		H-2; MHC-II;
General Note		The d variant has been observed in the following strains: DBA/2, DBA/2J BALB/c, BALB/cByJ, BALB/cJ, C57BLKS, NZB

Allele Symbol		Hc⁰
Allele Name		deficient
Common Name(s)		C5-; C5-d; C5-def; C5-deficient; hc^o;
Gene Symbol and Name		Hc, hemolytic complement
Chromosome		2
Gene Common Name(s)		C5; C5a; CPAMD4; FLJ17816; FLJ17822; He; MGC142298;
General Note		This is an allele characteristic of various inbred mouse strains including the following: A/HeJ, AKR/J, DBA/2J, NZB/B1NJ, SWR/J, B10.D2/oSnJ Hc was identified as a candidate gene for Abhr2 in a microarray analysis of lung mRNA from A/J, C3H/HeJ, and (A/J x C3H/HeJ)F1 x A/J backcross animals. Hc genotype shows statistically significant correlation to allergen-induced bronchial hyperresponsive phenotype. The A/J allele contains a 2 bp deletion resulting in deficient Hc mRNA and protein production and is associated with susceptibility to allergen-induced bronchial hyperresponsiveness. (J:108211)
Molecular Note		A 2 base "TA" deletion at positions 62 and 63 of an 83 base pair exon near the 5' end of the gene is found in the following mouse strains: A/HeJ, AKR/J, DBA/2J, NZB/B1NJ, SWR/J, B10.D2/oSnJ. The consequence of this deletion is the creation of a stop codon starting four bases after the deletion. A truncated product of 216 amino acids is predicted as a result although contradictory reports exist that a larger pro-C5 protein may be synthesized. Nevertheless, macrophages from mouse strains carrying this allele do not secrete complement 5. [MGI Ref ID J:23983]
Gene Symbol and Name		H2-T18, histocompatibility 2, T region locus 18
Chromosome		17
Gene Common Name(s)		H-2T18; TL Ag; Tla; thymus leukemia antigen;

Control Information

	Control
	000463 B10.D2-Hc¹ H2^d H2-T18^c/nSnJ
	000666 C57BL/10SnJ

Considerations for Choosing Controls

Colony Maintenance

Diet Information	LabDiet® 5K52/5K67

Related Strains

Strains carrying H2^d allele

005308 B10.Cg-H2^d Tg(TcraCl4,TcrbCl4)1Shrm/ShrmJ

005534 B10.Cg-H2^d Tg(Ins2-HA)165Bri/ShrmJ

005895 B10.Cg-Thy1^a H2^d Tg(TcraCl1,TcrbCl1)1Shrm/J

000462 B10.D2-H2^d/n2SnJ

000460 B10.D2-Hc⁰ H2^d H2-T18^c/o2SnJ

000463 B10.D2-Hc¹ H2^d H2-T18^c/nSnJ

003147 B10.D2-Hc¹ H2^d H2-T18^c/nSnJ-Tg(DO11.10)10Dlo/J

000360 B6.C-H2^d Mdmg1^BALB/cBy/aByJ

000359 B6.C-H2^d/bByJ

001893 BRVR.D2-H2^d/J

000437 D1.C-H2^d H2-T18^c/SnJ

003153 WLC.C-H2^d.GR-Mtv2/MorJ

003154 WLC.C-H2^d/MorJ

View Strains carrying H2^d (13 strains)

Strains carrying Hc⁰ allele

000645 A/HeJ

000646 A/J

000647 A/WySnJ

000648 AKR/J

000460 B10.D2-Hc⁰ H2^d H2-T18^c/o2SnJ

000657 CE/J

000671 DBA/2J

007048 DBA/2J-Gpnmb⁺/SjJ

001800 FVB/NJ

001491 FVB/NMob

000674 I/LnJ

001303 NOD.CB17-Prkdc^scid/J

001976 NOD/ShiLtJ

000684 NZB/BlNJ

000682 RF/J

000688 ST/bJ

000689 SWR/J

View Strains carrying Hc⁰ (17 strains)

Phenotypic Data

Mouse Phenome Database
Mouse Phenome Database / SNP Facility

Additional Web Information

Congenic Nomenclature
Genetic Quality Control Annual Report
JAX^® NOTES, October 1989; 439. Splenic Melanosis in Black Mice.

Animal Health Reports

Room Number MP13

Research Applications

This mouse can be used to support research in many areas including:

Developmental Biology Research
Lymphoid Tissue Defects (hematopoietic defects)

Immunology and Inflammation Research
CD Antigens, Antigen Receptors, and Histocompatibility Markers

H2^d related

Immunology and Inflammation Research
CD Antigens, Antigen Receptors, and Histocompatibility Markers

Hc⁰ related

Immunodeficiency (specific complement deficiency)

Research Tools
Immunology and Inflammation Research (specific complement deficiency) (C5 complement)

References

Additional References

Price and Supply Information

Strain Name:	*B10.D2-Hc⁰ H2^d H2-T18^c/oSnJ*
Stock Number:	000461

Price Details

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Supply Details

Standard Supply	Level 3. Up to 50 mice. Larger quantities or custom orders arranged upon request.
Supply Notes	Shipped at a specific age in weeks. Mice at a precise age in days, littermates and retired breeders are also available. Strains that must be genotyped are not available until five to seven weeks of age. Genomic DNA is available for this strain from the Mouse DNA Resource.
Licensing	See General Terms and Conditions below
Control Information	View Control Information in Strain Details.

General Terms and Conditions

View JAX^® Mice & Services Conditions of Use.

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

Ordering and Purchasing Information

Purchasing Information
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Surgical Services

Contact Information
Orders & Technical Support
Tel: 800.422.6423 or 207.288.5845
Fax: 207.288.6150
Technical Support Email Form

Go to JAX^® Mice Query Form

005308	B10.Cg-H2^d Tg(TcraCl4,TcrbCl4)1Shrm/ShrmJ
005534	B10.Cg-H2^d Tg(Ins2-HA)165Bri/ShrmJ
005895	B10.Cg-Thy1^a H2^d Tg(TcraCl1,TcrbCl1)1Shrm/J
000462	B10.D2-H2^d/n2SnJ
000460	B10.D2-Hc⁰ H2^d H2-T18^c/o2SnJ
000463	B10.D2-Hc¹ H2^d H2-T18^c/nSnJ
003147	B10.D2-Hc¹ H2^d H2-T18^c/nSnJ-Tg(DO11.10)10Dlo/J
000360	B6.C-H2^d Mdmg1^BALB/cBy/aByJ
000359	B6.C-H2^d/bByJ
001893	BRVR.D2-H2^d/J
000437	D1.C-H2^d H2-T18^c/SnJ
003153	WLC.C-H2^d.GR-Mtv2/MorJ
003154	WLC.C-H2^d/MorJ

000645	A/HeJ
000646	A/J
000647	A/WySnJ
000648	AKR/J
000460	B10.D2-Hc⁰ H2^d H2-T18^c/o2SnJ
000657	CE/J
000671	DBA/2J
007048	DBA/2J-Gpnmb⁺/SjJ
001800	FVB/NJ
001491	FVB/NMob
000674	I/LnJ
001303	NOD.CB17-Prkdc^scid/J
001976	NOD/ShiLtJ
000684	NZB/BlNJ
000682	RF/J
000688	ST/bJ
000689	SWR/J

Strain Name:

B10.D2-Hc0 H2d H2-T18c/oSnJ

Stock Number:

000461

Availability:

Level 3

General Terms and Conditions

Product Information

Strain Details

Hc0/Hc0

Gene & Allele Details

Control Information

Colony Maintenance

Related Strains

Phenotypic Data

Additional Web Information

Animal Health Reports

Research Applications

References

Price and Supply Information

Price Details

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Supply Details

General Terms and Conditions

The Jackson Laboratory's Genotype Promise

B10.D2-Hc⁰ H2^d H2-T18^c/oSnJ

Hc⁰/Hc⁰