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Genes & Alleles

H2;   H2-T18;   H2k;   ;

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Product Information

Strain Details

Type JAX® GEMM® Strain - Congenic Additional information on JAX® GEMM® Strains. Type JAX® GEMM® Strain - Major Histocompatibility Congenic Type JAX® GEMM® Strain - Mutant Strain Mating System Sibling x Sibling         (Female x Male) Species laboratory mouse Background Strain C57BL/10SnSg Donor Strain C57BR/cdJ Generation N9F102 (14-DEC-06)

Appearance
black, may exhibit white belly spots
Related Genotype: a/a

Strain Description
Some phenotypic parameters of the B10.BR-H2^k H2-T18^a/SgSnJ mice may have changed recently relative to the strain's previous performance. In order to confirm that a change had occurred and in order to better characterize any differences that may have arisen, animals were recovered from cryo-preserved embryos of the strain (Stock No. 004804) that had been frozen in 1991, and the two lines of B10.BR-H2^k H2-T18^a/SgSnJ were compared. Differences between the two strains have been identified in the CD4/CD8 ratios among several cell populations, and in some dendritic cell populations. As more information is gathered, this website will be updated. Both colonies of B10.BR-H2^k H2-T18^a/SgSnJ (Stock No's. 000465 and 004804) may exhibit white belly spots; these spots are considered a strain characteristic.

Gene & Allele Details

Allele Symbol		H2k
Allele Name		k variant
Common Name(s)		H-2k;
Gene Symbol and Name		H2, histocompatibility-2, MHC
Chromosome		17
Gene Common Name(s)		H-2; MHC-II;
General Note		The k variant has been observed in the following strains: C3H, C3H/HeJ, C3H/An, C3H/Bi, C3H/DiSn, C3H/St, CBA, CBA/CaJ, CBA/N, AKR/J, CE/J, C57BR/cdJ, C58/J, MA/J, RF/J, ST/bJ, MRL/MpJ-Faslpr/J
Gene Symbol and Name		H2-T18, histocompatibility 2, T region locus 18
Chromosome		17
Gene Common Name(s)		H-2T18; TL Ag; Tla; thymus leukemia antigen;

Control Information

	Control
	000666 C57BL/10SnJ	(approximate)
Considerations for Choosing Controls

Colony Maintenance

Diet Information	LabDiet® 5K52/5K67

Related Strains

Strains carrying   H2^k allele

004804	B10.BR-H2k H2-T18a/SgSnJJrep
006102	B10.Cg-H2k Tg(Il2/NFAT-luc)83Rinc/J
006100	B10.Cg-H2k Tg(NFkB/Fos-luc)26Rinc/J
001148	B6.AK-H2k/FlaEgJ
001895	B6.AK-H2k/J
001951	C.C3-H2k/LilMcdJ
001383	LT.MA-Glo1b H2k/J

View Strains carrying   H2^k     (7 strains)

Additional Web Information

Congenic Nomenclature
Genetic Quality Control Annual Report
JAX Notes, October 1989; 439. Splenic Melanosis in Black Mice.
Level B Pathogen, November /December 2003

Animal Health Reports

Room Number           MP13

Research Applications

This mouse can be used to support research in many areas including:

Immunology and Inflammation Research
CD Antigens, Antigen Receptors, and Histocompatibility Markers

H2^k related

Immunology and Inflammation Research
CD Antigens, Antigen Receptors, and Histocompatibility Markers

References

Additional References

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Price and Supply Information

Strain Name:	B10.BR-H2k H2-T18a/SgSnJ
Stock Number:	000465

Price Details

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Supply Details

Standard Supply	Level 2. Up to 100 mice. Larger quantities or custom orders arranged upon request.
Supply Notes	Shipped at a specific age in weeks. Mice at a precise age in days, littermates and retired breeders are also available. Strains that must be genotyped are not available until five to seven weeks of age. Genomic DNA is available for this strain from the Mouse DNA Resource.
Licensing	See General Terms and Conditions below
Control Information	View Control Information in Strain Details.

General Terms and Conditions

View JAX^® Mice & Services Conditions of Use.

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

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