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- Description
- Phenotype
- Genes & alleles
- Genotyping
- Health & husbandry
- References
- Purchasing information
- Terms of Use
Description
Strain Information
Former Names B10.BR-H2k H2-T18a/SgSnJ (Changed: 24-JUN-10 ) Type Congenic; Major Histocompatibility Congenic; Mutant Strain; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Mating System Sibling x Sibling (Female x Male) 01-MAR-06 Breeding Considerations This strain is a challenging breeder. Species laboratory mouse Background Strain C57BL/10SnSg Donor Strain C57BR/cdJ Generation N9F110 (02-JAN-10)
Generation Definitions
View larger imageAppearance
black, may exhibit white belly spots
Related Genotype: a/aDescription
Some phenotypic parameters of the B10.BR-H2k2 H2-T18a/SgSnJ mice may have changed recently relative to the strain's previous performance. In order to confirm that a change had occurred and in order to better characterize any differences that may have arisen, animals were recovered from cryopreserved embryos of the strain (Stock No. 004804) that had been frozen in 1991, and the two lines of B10.BR-H2k2 H2-T18a/SgSnJ were compared. Differences between the two strains have been identified in the CD4/CD8 ratios among several cell populations, and in some dendritic cell populations. As more information is gathered, this website will be updated. Both colonies of B10.BR-H2k2 H2-T18a/SgSnJ (Stock No's. 000465 and 004804) may exhibit white belly spots; these spots are considered a strain characteristic.
Control Information
| Control | ||
|---|---|---|
| 000666 C57BL/10SnJ | (approximate) | |
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying other alleles of H2-T18
View Strains carrying other alleles of H2-T18 (32 strains)
Additional Web Information
Genetic Quality Control Annual Report
JAX® NOTES, October 1989; 439. Splenic Melanosis in Black Mice.
Level B Pathogen, November /December 2003
Phenotype
Phenotype Information
This mouse can be used to support research in many areas including:
Immunology and Inflammation Research
CD Antigens, Antigen Receptors, and Histocompatibility Markers
Genes & Alleles
Gene & Allele Information provided by MGI
| Gene Symbol and Name | H2, histocompatibility-2, MHC | ||
|---|---|---|---|
| Chromosome | 17 | ||
| Gene Common Name(s) | H-2; MHC-II; | ||
| Gene Symbol and Name | H2-T18, histocompatibility 2, T region locus 18 | ||
| Chromosome | 17 | ||
| Gene Common Name(s) | H-2T18; TL Ag; Tla; thymus leukemia antigen; | ||
Genotyping
Genotyping Information
The Jackson Laboratory has not developed a genotyping protocol for H2 haplotypes. The following reference may helpful: Saha BK. J Immunol Meth 1996 Jul 17;194(1):77-83. (PMID: 8690943). Alternatively, haplotype-specific antibodies can be used with FACS.
Helpful Links
Genotyping resources and troubleshooting
Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Room Number AX5
Room Number MP19
Colony Maintenance
Mating System Sibling x Sibling (Female x Male) 01-MAR-06 Breeding Considerations This strain is a challenging breeder.
Purchasing information
Pricing, Supply Level & Notes, Controls
| Pricing for USA, Canada and Mexico shipping destinations |
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Live Mice
Weeks of Age Price (US dollars $) Gender Genotypes Provided 3-5 weeks $47.30 Female or Male Homozygous for H2k2, Homozygous for H2-T18a 6 weeks $49.55 Female or Male Homozygous for H2k2, Homozygous for H2-T18a 7 weeks $51.80 Female or Male Homozygous for H2k2, Homozygous for H2-T18a 8 weeks $54.05 Female or Male Homozygous for H2k2, Homozygous for H2-T18a Standard Supply
Level 3. Up to 50 mice. Larger quantities or custom orders arranged upon request.
Supply Notes
- Shipped at a specific age in weeks. Mice at a precise age in days, littermates and retired breeders are also available.
| Pricing for International shipping destinations |
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Live Mice
Weeks of Age Price (US dollars $) Gender Genotypes Provided 3-5 weeks $61.50 Female or Male Homozygous for H2k2, Homozygous for H2-T18a 6 weeks $64.50 Female or Male Homozygous for H2k2, Homozygous for H2-T18a 7 weeks $67.40 Female or Male Homozygous for H2k2, Homozygous for H2-T18a 8 weeks $70.30 Female or Male Homozygous for H2k2, Homozygous for H2-T18a Standard Supply
Level 3. Up to 50 mice. Larger quantities or custom orders arranged upon request.
Supply Notes
- Shipped at a specific age in weeks. Mice at a precise age in days, littermates and retired breeders are also available.
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Standard Supply
Level 3. Up to 50 mice. Larger quantities or custom orders arranged upon request.
General Supply Notes
- Genomic DNA is available for this strain from the Mouse DNA Resource.
Control Information
| Control | ||
|---|---|---|
| 000666 C57BL/10SnJ | (approximate) | |
| Considerations for Choosing Controls | ||
| Control Pricing Information for Genetically Engineered Mutant Strains. | ||
Payment Terms and Conditions
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See Terms of Use tab for General Terms and Conditions
The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering Information
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