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- Description
- Phenotype
- Genes & alleles
- Genotyping
- Health & husbandry
- References
- Purchasing information
- Terms of Use
Description
Strain Information
Type Congenic; Major Histocompatibility Congenic; Mutant Strain; Additional information on Genetically Engineered Mutant Mice. Mating System Homozygote x Homozygote (Female x Male) Species laboratory mouse Background Strain C57BL/10SnSg Donor Strain A/WySn Generation N11F104 (03-JAN-08) Appearance
black
Related Genotype: a/a
Control Information
| Control | ||
|---|---|---|
| 000666 C57BL/10SnJ | (approximate) | |
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying H2a allele
003240 B6;B10.A-H2a-Tg(H2KmPCC)2939Stoe/J View Strains carrying H2a (1 strain)
Additional Web Information
Congenic Nomenclature
Genetic Quality Control Annual Report
JAX® NOTES, October 1989; 439. Splenic Melanosis in Black Mice.
Phenotype
Phenotype Information
This mouse can be used to support research in many areas including:
H2a relatedImmunology and Inflammation Research
CD Antigens, Antigen Receptors, and Histocompatibility Markers
Immunology and Inflammation Research
CD Antigens, Antigen Receptors, and Histocompatibility Markers
Genes & Alleles
Gene & Allele Information
| Allele Symbol | H2a | ||
|---|---|---|---|
| Allele Name | a variant | ||
| Allele Type | Not Applicable | ||
| Gene Symbol and Name | H2, histocompatibility-2, MHC | ||
| Chromosome | 17 | ||
| Gene Common Name(s) | H-2; MHC-II; | ||
| General Note | The a variant has been observed in the following strains: A/J, B10.A | ||
| Gene Symbol and Name | H2-T18, histocompatibility 2, T region locus 18 | ||
| Chromosome | 17 | ||
| Gene Common Name(s) | H-2T18; TL Ag; Tla; thymus leukemia antigen; | ||
Genotyping
Genotyping Information
This strain will not have a genotyping protocol or one is not currently available.
Helpful Links
Optimizing PCR Protocols
References
References
Additional References
H2a relatedCemerski S; Das J; Locasale J; Arnold P; Giurisato E; Markiewicz MA; Fremont D; Allen PM; Chakraborty AK; Shaw AS. 2007. The stimulatory potency of T cell antigens is influenced by the formation of the immunological synapse. Immunity 26(3):345-55. [PubMed: 17346997] [MGI Ref ID J:120073]
El-Sawy T; Belperio JA; Strieter RM; Remick DG; Fairchild RL. 2005. Inhibition of polymorphonuclear leukocyte-mediated graft damage synergizes with short-term costimulatory blockade to prevent cardiac allograft rejection. Circulation 112(3):320-31. [PubMed: 15998678] [MGI Ref ID J:117219]
Klein J; Figueroa F; David CS. 1983. H-2 haplotypes, genes and antigens: second listing. II. The H-2 complex. Immunogenetics 17(6):553-96. [PubMed: 6407984] [MGI Ref ID J:7097]
Miyashita N; Migita S; Moriwaki K. 1987. Effects of H-2 complex and non-H-2 background on urethane-induced chromosomal aberrations in mice. Mutat Res 176(1):59-67. [PubMed: 3099189] [MGI Ref ID J:109945]
Peterson KE; Iwashiro M; Hasenkrug KJ; Chesebro B. 2000. Major histocompatibility complex class I gene controls the generation of gamma interferon-producing CD4(+) and CD8(+) T cells important for recovery from friend retrovirus-induced leukemia J Virol 74(11):5363-7. [PubMed: 10799615] [MGI Ref ID J:62492]
Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Room Number MP19
Colony Maintenance
Mating System Homozygote x Homozygote (Female x Male) Diet Information LabDiet® 5K52/5K67
Purchasing information
Pricing, Supply Level & Notes, Controls, General Terms & Conditions
Pricing
| Pricing for USA, Canada and Mexico shipping destinations |
|
*Price(s) in US dollars ($)
Weeks of Age Price* Gender Genotypes Provided 3-5 weeks $18.80 Female or Male Homozygous for H2a, Homozygous for H2-T18a 6 weeks $20.70 Female or Male Homozygous for H2a, Homozygous for H2-T18a 7 weeks $22.60 Female or Male Homozygous for H2a, Homozygous for H2-T18a 8 weeks $24.50 Female or Male Homozygous for H2a, Homozygous for H2-T18a 9 weeks $26.40 Female or Male Homozygous for H2a, Homozygous for H2-T18a 10 weeks $28.30 Female or Male Homozygous for H2a, Homozygous for H2-T18a
Additional Supply Details
| Supply Notes |
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| Pricing for International shipping destinations |
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*Price(s) in US dollars ($)
Weeks of Age Price* Gender Genotypes Provided 3-5 weeks $24.50 Female or Male Homozygous for H2a, Homozygous for H2-T18a 6 weeks $27.00 Female or Male Homozygous for H2a, Homozygous for H2-T18a 7 weeks $29.50 Female or Male Homozygous for H2a, Homozygous for H2-T18a 8 weeks $32.00 Female or Male Homozygous for H2a, Homozygous for H2-T18a 9 weeks $34.50 Female or Male Homozygous for H2a, Homozygous for H2-T18a 10 weeks $37.00 Female or Male Homozygous for H2a, Homozygous for H2-T18a
Additional Supply Details
| Supply Notes |
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Supply Details
| Standard Supply | Level 3. Up to 50 mice. Larger quantities or custom orders arranged upon request. |
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| Supply Notes |
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Control Information
| Control | ||
|---|---|---|
| 000666 C57BL/10SnJ | (approximate) | |
| Considerations for Choosing Controls | ||
| USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
| International - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
General Terms and Conditions
See Terms of Use
The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
Purchasing Information
JAX® Mice Orders
Surgical Services
Contact Information
Orders & Technical Support
Tel: 800.422.6423 or 207.288.5845
Fax: 207.288.6150
Technical Support Email Form
Terms of Use
Terms of Use
General Terms and Conditions
Contact information
General inquiries
Contracts Administration
| phone: | 207-288-6470 |
| fax: | 207-288-6655 |
JAX® Mice & Services Conditions of Use
“Each recipient institution, including its employees and other researchers under its control (RECIPIENT), of mice or services using mice from The Jackson Laboratory (TJL) agrees that such mice, descendants of those mice derived by inbreeding or crossbreeding, including unmodified derivatives of those mice or their descendants (“MICE”) shall not be: (i) used for any purpose other than the internal research of the RECIPIENT, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services with respect to MICE. Acceptance of MICE from TJL shall be deemed agreement by RECIPIENT to these conditions, and departure from these conditions requires The Jackson Laboratory’s prior written authorization.”No Warranty
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In no event shall The Jackson Laboratory, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, products or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of The Jackson Laboratory, its agents or employees. In purchasing or receiving MICE, products or services from The Jackson Laboratory, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges The Jackson Laboratory from all such causes of action or damages, and further agrees to defend and indemnify The Jackson Laboratory from any costs or damages arising out of any third party claims.
MICE and biological materials are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.
The foregoing represents the General Terms and Conditions applicable to The Jackson Laboratory’s MICE, products and services. In addition, special terms and conditions of sale of certain MICE, products and services may be set forth separately in The Jackson Laboratory web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, products and services by The Jackson Laboratory, and by its licensees and distributors.
Acceptance of delivery of MICE, products or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on The Jackson Laboratory, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, products services by The Jackson Laboratory.