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| In this congenic strain, the A/WySn H2 complex (H2a), including the nonclassical class 1 T18a (thymus leukemia (TL) antigen) locus, was introgressed onto the C57BL/10SnSg background. Mice congenic for H2 haplotypes are widely used in immunologic research and often vary in immune response and pathogen susceptibility from the recipient strain. | |||||||||||||||
- Description
- Disease & phenotype
- Genes & alleles
- Genotyping
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Description
Strain Information
Former Names B10.A/SgSnJ (Changed: 07-MAR-12 ) Type Congenic; Major Histocompatibility Congenic; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Mating System Homozygote x Homozygote (Female x Male) 01-MAR-06 Breeding Considerations This strain is a good breeder. Species laboratory mouse Background Strain C57BL/10SnSg Donor Strain A/WySn Generation N11F119 (17-SEP-12)
Generation Definitions
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black
Related Genotype: a/aDescription
In this congenic strain, the A/WySn H2 complex (H2a), including the nonclassical class 1 T18a (thymus leukemia (TL) antigen) locus, on chromosome 17 was introgressed onto the C57BL/10SnSg background. H2a is a recombinant haplotype and occurs in the A inbred strains. The H2a haplotype contains the following alleles: class I K - k, class II A and E - k, class I D - d, and nonclassical loci Qa and T18 - a. In contrast to this congenic, C57BL/6 and C57BL/10 mice carry a natural deletion of the T18 (T18b) gene. Mice congenic for H2 haplotypes are widely used in immunologic research and often vary in immune response and pathogen susceptibility from the recipient strain.Development
In this congenic strain, the A/WySn H2 complex (H2a), including the class 1 T18a (thymus leukemia (TL) antigen) locus, on chromosome 17 was introgressed onto the C57BL/10SnSg background for 10+ generations.
Control Information
| Control | ||
|---|---|---|
| 000666 C57BL/10SnJ | (approximate) | |
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying H2-T18a allele
000465 B10.BR-H2k2 H2-T18a/SgSnJ 004804 B10.BR-H2k2 H2-T18a/SgSnJJrep 001737 B6.Cg-Hrhr H2-T18a/J View Strains carrying H2-T18a (3 strains)
003240 B6;B10.A-H2a-Tg(H2KmPCC)2939Stoe/J
Additional Web Information
JAX® NOTES, October 1989; 439. Splenic Melanosis in Black Mice.
Phenotype
Phenotype Information
This mouse can be used to support research in many areas including:
H2a relatedImmunology, Inflammation and Autoimmunity Research
CD Antigens, Antigen Receptors, and Histocompatibility Markers
Immunology, Inflammation and Autoimmunity Research
CD Antigens, Antigen Receptors, and Histocompatibility Markers
Genes & Alleles
Gene & Allele Information provided by MGI
| Allele Symbol | H2-T18a | ||
|---|---|---|---|
| Allele Name | a variant | ||
| Allele Type | Not Applicable | ||
| Common Name(s) | Tlaa; | ||
| Gene Symbol and Name | H2-T18, histocompatibility 2, T region locus 18 | ||
| Chromosome | 17 | ||
| Gene Common Name(s) | H-2T18; TL Ag; Tla; thymus leukemia antigen; | ||
| Molecular Note | The allele H2-T18a determines presence of the antigenic specificities TL.1, 2, 3, 5, 6, 7 and occurs in strains A, C57BR, C58, SJL, and others. | ||
| Allele Symbol | H2a | ||
| Allele Name | a variant | ||
| Allele Type | Not Applicable | ||
| Gene Symbol and Name | H2, histocompatibility-2, MHC | ||
| Chromosome | 17 | ||
| Gene Common Name(s) | H-2; MHC-II; | ||
| General Note | The a variant has been observed in the following strains: A/J, B10.A | ||
Genotyping
Genotyping Information
The Jackson Laboratory has not developed a genotyping protocol for H2 haplotypes. The following reference may helpful: Saha BK. J Immunol Meth 1996 Jul 17;194(1):77-83. (PMID: 8690943). Alternatively, haplotype-specific antibodies can be used with FACS.
Helpful Links
Genotyping resources and troubleshooting
References
References provided by MGI
Additional References
H2-T18a relatedH2a relatedBOYSE EA; OLD LJ; LUELL S. 1964. GENETIC DETERMINATION OF THE TL (THYMUSLEUKAEMIA) ANTIGEN IN THE MOUSE. Nature 201:779. [PubMed: 14161199] [MGI Ref ID J:13118]
Chen YT; Obata Y; Stockert E; Old LJ. 1985. Thymus-leukemia (TL) antigens of the mouse. Analysis of TL mRNA and TL cDNA TL+ and TL- strains. J Exp Med 162(4):1134-48. [PubMed: 3840195] [MGI Ref ID J:8035]
Chorney MJ; Shen FW; Tung JS; Boyse EA. 1985. Additional products of the Tla locus of the mouse. Proc Natl Acad Sci U S A 82(20):7044-7. [PubMed: 3876563] [MGI Ref ID J:8045]
Flaherty L; Rinchik E. 1980. A new allele and antigen at the Tla locus. Immunogenetics 11(2):205-8. [PubMed: 6157647] [MGI Ref ID J:6368]
Gowdy KM; Nugent JL; Martinu T; Potts E; Snyder LD; Foster WM; Palmer SM. 2012. Protective role of T-bet and Th1 cytokines in pulmonary graft-versus-host disease and peribronchiolar fibrosis. Am J Respir Cell Mol Biol 46(2):249-56. [PubMed: 21960548] [MGI Ref ID J:191909]
Shen FW; Chorney MJ; Boyse EA. 1982. Further polymorphism of the Tla locus defined by monoclonal TL antibodies. Immunogenetics 15(6):573-8. [PubMed: 7106865] [MGI Ref ID J:6828]
Yamazaki K; Beauchamp GK; Bard J; Thomas L; Boyse EA. 1982. Chemosensory recognition of phenotypes determined by the Tla and H-2K regions of chromosome 17 of the mouse. Proc Natl Acad Sci U S A 79(24):7828-31. [PubMed: 6961454] [MGI Ref ID J:6964]
Cemerski S; Das J; Locasale J; Arnold P; Giurisato E; Markiewicz MA; Fremont D; Allen PM; Chakraborty AK; Shaw AS. 2007. The stimulatory potency of T cell antigens is influenced by the formation of the immunological synapse. Immunity 26(3):345-55. [PubMed: 17346997] [MGI Ref ID J:120073]
El-Sawy T; Belperio JA; Strieter RM; Remick DG; Fairchild RL. 2005. Inhibition of polymorphonuclear leukocyte-mediated graft damage synergizes with short-term costimulatory blockade to prevent cardiac allograft rejection. Circulation 112(3):320-31. [PubMed: 15998678] [MGI Ref ID J:117219]
Klein J; Figueroa F; David CS. 1983. H-2 haplotypes, genes and antigens: second listing. II. The H-2 complex. Immunogenetics 17(6):553-96. [PubMed: 6407984] [MGI Ref ID J:7097]
Miyashita N; Migita S; Moriwaki K. 1987. Effects of H-2 complex and non-H-2 background on urethane-induced chromosomal aberrations in mice. Mutat Res 176(1):59-67. [PubMed: 3099189] [MGI Ref ID J:109945]
Peterson KE; Iwashiro M; Hasenkrug KJ; Chesebro B. 2000. Major histocompatibility complex class I gene controls the generation of gamma interferon-producing CD4(+) and CD8(+) T cells important for recovery from friend retrovirus-induced leukemia J Virol 74(11):5363-7. [PubMed: 10799615] [MGI Ref ID J:62492]
Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Room Number AX5
Colony Maintenance
Mating System Homozygote x Homozygote (Female x Male) 01-MAR-06 Breeding Considerations This strain is a good breeder.
Pricing and Purchasing
Pricing, Supply Level & Notes, Controls
| Pricing for USA, Canada and Mexico shipping destinations |
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Live Mice
Weeks of Age Price per mouse (US dollars $) Gender Genotypes Provided 3 weeks $25.90 Female or Male Homozygous for H2a, Homozygous for H2-T18a 4 weeks $25.90 Female or Male Homozygous for H2a, Homozygous for H2-T18a 5 weeks $25.90 Female or Male Homozygous for H2a, Homozygous for H2-T18a 6 weeks $28.25 Female or Male Homozygous for H2a, Homozygous for H2-T18a 7 weeks $30.65 Female or Male Homozygous for H2a, Homozygous for H2-T18a 8 weeks $33.05 Female or Male Homozygous for H2a, Homozygous for H2-T18a 9 weeks $35.40 Female or Male Homozygous for H2a, Homozygous for H2-T18a 10 weeks $37.80 Female or Male Homozygous for H2a, Homozygous for H2-T18a Standard Supply
Level 4. Up to 10 mice. Larger quantities or custom orders arranged upon request. Expected delivery up to one to three months.
Supply Notes
- Shipped at a specific age in weeks. Mice at a precise age in days, littermates and retired breeders are also available.
| Pricing for International shipping destinations |
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Live Mice
Weeks of Age Price per mouse (US dollars $) Gender Genotypes Provided 3 weeks $33.70 Female or Male Homozygous for H2a, Homozygous for H2-T18a 4 weeks $33.70 Female or Male Homozygous for H2a, Homozygous for H2-T18a 5 weeks $33.70 Female or Male Homozygous for H2a, Homozygous for H2-T18a 6 weeks $36.80 Female or Male Homozygous for H2a, Homozygous for H2-T18a 7 weeks $39.90 Female or Male Homozygous for H2a, Homozygous for H2-T18a 8 weeks $43.00 Female or Male Homozygous for H2a, Homozygous for H2-T18a 9 weeks $46.10 Female or Male Homozygous for H2a, Homozygous for H2-T18a 10 weeks $49.20 Female or Male Homozygous for H2a, Homozygous for H2-T18a Standard Supply
Level 4. Up to 10 mice. Larger quantities or custom orders arranged upon request. Expected delivery up to one to three months.
Supply Notes
- Shipped at a specific age in weeks. Mice at a precise age in days, littermates and retired breeders are also available.
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Standard Supply
Level 4. Up to 10 mice. Larger quantities or custom orders arranged upon request. Expected delivery up to one to three months.
General Supply Notes
- Genomic DNA is available for this strain from the Mouse DNA Resource.
Control Information
| Control | ||
|---|---|---|
| 000666 C57BL/10SnJ | (approximate) | |
| Considerations for Choosing Controls | ||
| Control Pricing Information for Genetically Engineered Mutant Strains. | ||
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering Information
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