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Type Congenic; Major Histocompatibility Congenic; Mutant Strain; Additional information on Genetically Engineered Mutant Mice. Mating System Homozygote x Homozygote (Female x Male) Species laboratory mouse Background Strain A/WySn Donor Strain Non-inbred Swiss Generation N14F117 (03-JAN-08) Appearance
albino
Related Genotype: a/a Typr1b/Tyrp1b Tyrc/TyrcDevelopment
The H2s haplotype, including H2-T18b , was transferred by George Snell from a non-inbred Swiss mouse to the A/WySn strain background by 14 generations of backcrossing (Klein 1968, p. 804).
| Control | ||
|---|---|---|
| 000647 A/WySnJ | ||
| Considerations for Choosing Controls | ||
Strains carrying H2s allele
001953 B10.S-H2s/SgMcdJ 000966 B6.SJL-H2s C3c/1CyJ View Strains carrying H2s (2 strains)
Congenic Nomenclature
Genetic Quality Control Annual Report
View Research Applications
Research Applications
This mouse can be used to support research in many areas including:
H2s relatedImmunology and Inflammation Research
Autoimmunity (experimental allergic encephalomyelitis (EAE))
CD Antigens, Antigen Receptors, and Histocompatibility Markers
Immunology and Inflammation Research
CD Antigens, Antigen Receptors, and Histocompatibility Markers
| Allele Symbol | H2s | ||
|---|---|---|---|
| Allele Name | s variant | ||
| Allele Type | Not Applicable | ||
| Gene Symbol and Name | H2, histocompatibility-2, MHC | ||
| Chromosome | 17 | ||
| Gene Common Name(s) | H-2; MHC-II; | ||
| General Note | The s variant has been observed in the following strains: SJL/J, A.SW, B10.S | ||
| Gene Symbol and Name | H2-T18, histocompatibility 2, T region locus 18 | ||
| Chromosome | 17 | ||
| Gene Common Name(s) | H-2T18; TL Ag; Tla; thymus leukemia antigen; | ||
This strain will not have a genotyping protocol or one is not currently available.
Helpful Links
Optimizing PCR Protocols
Tsunoda I; Kuang LQ; Theil DJ; Fujinami RS. 2000. Antibody association with a novel model for primary progressive multiple sclerosis: induction of relapsing-remitting and progressive forms of EAE in H2s mouse strains. Brain Pathol 10(3):402-18. [PubMed: 10885659] [MGI Ref ID J:137818]
Tsunoda I; Libbey JE; Kuang LQ; Terry EJ; Fujinami RS. 2005. Massive apoptosis in lymphoid organs in animal models for primary and secondary progressive multiple sclerosis. Am J Pathol 167(6):1631-46. [PubMed: 16314476] [MGI Ref ID J:137817]
H2s relatedChiorazzi N; Fox DA; Katz DH. 1977. Hapten-specific IgE antibody responses in mice. VII. Conversion of IgE non-responder strains to IgE responders by elimination of suppressor T cell activity. J Immunol 118(1):48-54. [PubMed: 299762] [MGI Ref ID J:5739]
Clarke SR; Barnden M; Kurts C; Carbone FR; Miller JF; Heath WR. 2000. Characterization of the ovalbumin-specific TCR transgenic line OT-I: MHC elements for positive and negative selection. Immunol Cell Biol 78(2):110-7. [PubMed: 10762410] [MGI Ref ID J:133645]
Clatch RJ; Melvold RW; Miller SD; Lipton HL. 1985. Theiler's murine encephalomyelitis virus (TMEV)-induced demyelinating disease in mice is influenced by the H-2D region: correlation with TEMV-specific delayed-type hypersensitivity. J Immunol 135(2):1408-14. [PubMed: 3925009] [MGI Ref ID J:85035]
El-Sawy T; Belperio JA; Strieter RM; Remick DG; Fairchild RL. 2005. Inhibition of polymorphonuclear leukocyte-mediated graft damage synergizes with short-term costimulatory blockade to prevent cardiac allograft rejection. Circulation 112(3):320-31. [PubMed: 15998678] [MGI Ref ID J:117219]
Fischer Lindahl K. 1997. On naming H2 haplotypes: functional significance of MHC class Ib alleles. Immunogenetics 46(1):53-62. [PubMed: 9148789] [MGI Ref ID J:41130]
Havarinasab S; Haggqvist B; Bjorn E; Pollard KM; Hultman P. 2005. Immunosuppressive and autoimmune effects of thimerosal in mice. Toxicol Appl Pharmacol 204(2):109-21. [PubMed: 15808517] [MGI Ref ID J:97345]
Kappel CA; Dal Canto MC; Melvold RW; Kim BS. 1991. Hierarchy of effects of the MHC and T cell receptor beta-chain genes in susceptibility to Theiler's murine encephalomyelitis virus-induced demyelinating disease. J Immunol 147(12):4322-6. [PubMed: 1836484] [MGI Ref ID J:2746]
Klein J; Figueroa F; David CS. 1983. H-2 haplotypes, genes and antigens: second listing. II. The H-2 complex. Immunogenetics 17(6):553-96. [PubMed: 6407984] [MGI Ref ID J:7097]
Lipton HL; Melvold R. 1984. Genetic analysis of susceptibility to Theiler's virus-induced demyelinating disease in mice. J Immunol 132(4):1821-5. [PubMed: 6699403] [MGI Ref ID J:25443]
Mendiratta SK; Kovalik JP; Hong S; Singh N; Martin WD; Van Kaer L. 1999. Peptide dependency of alloreactive CD4+ T cell responses. Int Immunol 11(3):351-60. [PubMed: 10221647] [MGI Ref ID J:110542]
Miyashita N; Migita S; Moriwaki K. 1987. Effects of H-2 complex and non-H-2 background on urethane-induced chromosomal aberrations in mice. Mutat Res 176(1):59-67. [PubMed: 3099189] [MGI Ref ID J:109945]
Murphy DB. 1986. Overview: the murine MHC. In: Handbook of Experimental Immunology. Vol. 3, Genetic and Molecular Immunology. Blackwell Scientific Publ., Oxford. [MGI Ref ID J:30731]
Tsunoda I; Kuang LQ; Theil DJ; Fujinami RS. 2000. Antibody association with a novel model for primary progressive multiple sclerosis: induction of relapsing-remitting and progressive forms of EAE in H2s mouse strains. Brain Pathol 10(3):402-18. [PubMed: 10885659] [MGI Ref ID J:137818]
Tsunoda I; Libbey JE; Kuang LQ; Terry EJ; Fujinami RS. 2005. Massive apoptosis in lymphoid organs in animal models for primary and secondary progressive multiple sclerosis. Am J Pathol 167(6):1631-46. [PubMed: 16314476] [MGI Ref ID J:137817]
Warfvinge K; Hansson H; Hultman P. 1995. Systemic autoimmunity due to mercury vapor exposure in genetically susceptible mice: dose-response studies. Toxicol Appl Pharmacol 132(2):299-309. [PubMed: 7785057] [MGI Ref ID J:27810]
Zhang ZX; Yang L; Young KJ; DuTemple B; Zhang L. 2000. Identification of a previously unknown antigen-specific regulatory T cell and its mechanism of suppression. Nat Med 6(7):782-9. [PubMed: 10888927] [MGI Ref ID J:118729]
Animal Health Reports
Room Number AX8
Colony Maintenance
Mating System Homozygote x Homozygote (Female x Male) Diet Information LabDiet® 5K52/5K67
| Pricing for USA, Canada and Mexico shipping destinations |
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*Price(s) in US dollars ($)
Weeks of Age Price* Gender Genotypes Provided 3-5 weeks $37.70 Female or Male Homozygous for H2s, Homozygous for H2-T18b 6 weeks $39.60 Female or Male Homozygous for H2s, Homozygous for H2-T18b 7 weeks $41.50 Female or Male Homozygous for H2s, Homozygous for H2-T18b 8 weeks $43.40 Female or Male Homozygous for H2s, Homozygous for H2-T18b
| Supply Notes |
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| Pricing for International shipping destinations |
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*Price(s) in US dollars ($)
Weeks of Age Price* Gender Genotypes Provided 3-5 weeks $49.10 Female or Male Homozygous for H2s, Homozygous for H2-T18b 6 weeks $51.60 Female or Male Homozygous for H2s, Homozygous for H2-T18b 7 weeks $54.10 Female or Male Homozygous for H2s, Homozygous for H2-T18b 8 weeks $56.60 Female or Male Homozygous for H2s, Homozygous for H2-T18b
| Supply Notes |
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| Standard Supply | Level 4. Up to 10 mice. Larger quantities or custom orders arranged upon request. Expected delivery up to one to three months. |
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| Supply Notes |
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| Control | ||
|---|---|---|
| 000647 A/WySnJ | ||
| Considerations for Choosing Controls | ||
| USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
| International - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
Purchasing Information
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| phone: | 207-288-6470 |
| fax: | 207-288-6655 |
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