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| This is an H2 congenic strain in which the H2s and H2-T18b alleles were transferred from a non-inbred Swiss mouse to the A/WySn strain. | |||||||||||
- Description
- Phenotype
- Genes & alleles
- Genotyping
- Health & husbandry
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Description
Strain Information
Type Congenic; Major Histocompatibility Congenic; Mutant Strain; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Mating System Homozygote x Homozygote (Female x Male) 01-MAR-06 Species laboratory mouse Background Strain A/WySn Donor Strain Non-inbred Swiss Generation N14F117 (03-JAN-08)
View larger imageAppearance
albino
Related Genotype: a/a Typr1b/Tyrp1b Tyrc/TyrcDevelopment
The H2s haplotype, including H2-T18b , was transferred by George Snell from a non-inbred Swiss mouse to the A/WySn strain background by 14 generations of backcrossing (Klein 1968, p. 804).
Control Information
| Control | ||
|---|---|---|
| 000647 A/WySnJ | ||
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying H2s allele
001953 B10.S-H2s/SgMcdJ 000966 B6.SJL-H2s C3c/1CyJ View Strains carrying H2s (2 strains)
Additional Web Information
Genetic Quality Control Annual Report
Phenotype
Phenotype Information
This mouse can be used to support research in many areas including:
H2s relatedImmunology and Inflammation Research
Autoimmunity
experimental allergic encephalomyelitis (EAE)
CD Antigens, Antigen Receptors, and Histocompatibility Markers
Immunology and Inflammation Research
CD Antigens, Antigen Receptors, and Histocompatibility Markers
Genes & Alleles
Gene & Allele Information
| Allele Symbol | H2s | ||
|---|---|---|---|
| Allele Name | s variant | ||
| Allele Type | Not Applicable | ||
| Gene Symbol and Name | H2, histocompatibility-2, MHC | ||
| Chromosome | 17 | ||
| Gene Common Name(s) | H-2; MHC-II; | ||
| General Note | The s variant has been observed in the following strains: SJL/J, A.SW, B10.S | ||
| Gene Symbol and Name | H2-T18, histocompatibility 2, T region locus 18 | ||
| Chromosome | 17 | ||
| Gene Common Name(s) | H-2T18; TL Ag; Tla; thymus leukemia antigen; | ||
Genotyping
Genotyping Information
The Jackson Laboratory has not developed a genotyping protocol for H2 haplotypes. The following reference may helpful: Saha BK. J Immunol Meth 1996 Jul 17;194(1):77-83. (PMID: 8690943). Alternatively, haplotype-specific antibodies can be used with FACS.
Helpful Links
Genotyping resources and troubleshooting
References
References
Additional References
Tsunoda I; Kuang LQ; Theil DJ; Fujinami RS. 2000. Antibody association with a novel model for primary progressive multiple sclerosis: induction of relapsing-remitting and progressive forms of EAE in H2s mouse strains. Brain Pathol 10(3):402-18. [PubMed: 10885659] [MGI Ref ID J:137818]
Tsunoda I; Libbey JE; Kuang LQ; Terry EJ; Fujinami RS. 2005. Massive apoptosis in lymphoid organs in animal models for primary and secondary progressive multiple sclerosis. Am J Pathol 167(6):1631-46. [PubMed: 16314476] [MGI Ref ID J:137817]
H2s relatedChiorazzi N; Fox DA; Katz DH. 1977. Hapten-specific IgE antibody responses in mice. VII. Conversion of IgE non-responder strains to IgE responders by elimination of suppressor T cell activity. J Immunol 118(1):48-54. [PubMed: 299762] [MGI Ref ID J:5739]
Clarke SR; Barnden M; Kurts C; Carbone FR; Miller JF; Heath WR. 2000. Characterization of the ovalbumin-specific TCR transgenic line OT-I: MHC elements for positive and negative selection. Immunol Cell Biol 78(2):110-7. [PubMed: 10762410] [MGI Ref ID J:133645]
Clatch RJ; Melvold RW; Miller SD; Lipton HL. 1985. Theiler's murine encephalomyelitis virus (TMEV)-induced demyelinating disease in mice is influenced by the H-2D region: correlation with TEMV-specific delayed-type hypersensitivity. J Immunol 135(2):1408-14. [PubMed: 3925009] [MGI Ref ID J:85035]
El-Sawy T; Belperio JA; Strieter RM; Remick DG; Fairchild RL. 2005. Inhibition of polymorphonuclear leukocyte-mediated graft damage synergizes with short-term costimulatory blockade to prevent cardiac allograft rejection. Circulation 112(3):320-31. [PubMed: 15998678] [MGI Ref ID J:117219]
Fischer Lindahl K. 1997. On naming H2 haplotypes: functional significance of MHC class Ib alleles. Immunogenetics 46(1):53-62. [PubMed: 9148789] [MGI Ref ID J:41130]
Havarinasab S; Haggqvist B; Bjorn E; Pollard KM; Hultman P. 2005. Immunosuppressive and autoimmune effects of thimerosal in mice. Toxicol Appl Pharmacol 204(2):109-21. [PubMed: 15808517] [MGI Ref ID J:97345]
Kappel CA; Dal Canto MC; Melvold RW; Kim BS. 1991. Hierarchy of effects of the MHC and T cell receptor beta-chain genes in susceptibility to Theiler's murine encephalomyelitis virus-induced demyelinating disease. J Immunol 147(12):4322-6. [PubMed: 1836484] [MGI Ref ID J:2746]
Klein J; Figueroa F; David CS. 1983. H-2 haplotypes, genes and antigens: second listing. II. The H-2 complex. Immunogenetics 17(6):553-96. [PubMed: 6407984] [MGI Ref ID J:7097]
Lipton HL; Melvold R. 1984. Genetic analysis of susceptibility to Theiler's virus-induced demyelinating disease in mice. J Immunol 132(4):1821-5. [PubMed: 6699403] [MGI Ref ID J:25443]
Mendiratta SK; Kovalik JP; Hong S; Singh N; Martin WD; Van Kaer L. 1999. Peptide dependency of alloreactive CD4+ T cell responses. Int Immunol 11(3):351-60. [PubMed: 10221647] [MGI Ref ID J:110542]
Miyashita N; Migita S; Moriwaki K. 1987. Effects of H-2 complex and non-H-2 background on urethane-induced chromosomal aberrations in mice. Mutat Res 176(1):59-67. [PubMed: 3099189] [MGI Ref ID J:109945]
Murphy DB. 1986. Overview: the murine MHC. In: Handbook of Experimental Immunology. Vol. 3, Genetic and Molecular Immunology. Blackwell Scientific Publ., Oxford. [MGI Ref ID J:30731]
Tsunoda I; Kuang LQ; Theil DJ; Fujinami RS. 2000. Antibody association with a novel model for primary progressive multiple sclerosis: induction of relapsing-remitting and progressive forms of EAE in H2s mouse strains. Brain Pathol 10(3):402-18. [PubMed: 10885659] [MGI Ref ID J:137818]
Tsunoda I; Libbey JE; Kuang LQ; Terry EJ; Fujinami RS. 2005. Massive apoptosis in lymphoid organs in animal models for primary and secondary progressive multiple sclerosis. Am J Pathol 167(6):1631-46. [PubMed: 16314476] [MGI Ref ID J:137817]
Warfvinge K; Hansson H; Hultman P. 1995. Systemic autoimmunity due to mercury vapor exposure in genetically susceptible mice: dose-response studies. Toxicol Appl Pharmacol 132(2):299-309. [PubMed: 7785057] [MGI Ref ID J:27810]
Zhang ZX; Yang L; Young KJ; DuTemple B; Zhang L. 2000. Identification of a previously unknown antigen-specific regulatory T cell and its mechanism of suppression. Nat Med 6(7):782-9. [PubMed: 10888927] [MGI Ref ID J:118729]
Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Room Number AX8
Colony Maintenance
Mating System Homozygote x Homozygote (Female x Male) 01-MAR-06 Diet Information LabDiet® 5K52/5K67
Purchasing information
Pricing, Supply Level & Notes, Controls, General Terms & Conditions
Pricing
| Pricing for USA, Canada and Mexico shipping destinations |
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Weeks of Age Price (US dollars $) Gender Genotypes Provided 3-5 weeks $40.75 Female or Male Homozygous for H2s, Homozygous for H2-T18b 6 weeks $42.80 Female or Male Homozygous for H2s, Homozygous for H2-T18b 7 weeks $44.85 Female or Male Homozygous for H2s, Homozygous for H2-T18b 8 weeks $46.90 Female or Male Homozygous for H2s, Homozygous for H2-T18b
Additional Supply Details
| Pricing for International shipping destinations |
|
Weeks of Age Price (US dollars $) Gender Genotypes Provided 3-5 weeks $53.00 Female or Male Homozygous for H2s, Homozygous for H2-T18b 6 weeks $55.70 Female or Male Homozygous for H2s, Homozygous for H2-T18b 7 weeks $58.40 Female or Male Homozygous for H2s, Homozygous for H2-T18b 8 weeks $61.10 Female or Male Homozygous for H2s, Homozygous for H2-T18b
Additional Supply Details
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Supply Details
| Standard Supply | Level 4. Up to 10 mice. Larger quantities or custom orders arranged upon request. Expected delivery up to one to three months. |
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| Supply Notes |
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Control Information
| Control | ||
|---|---|---|
| 000647 A/WySnJ | ||
| Considerations for Choosing Controls | ||
| USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
| International - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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