Strain Name:

J.Cg-Oca2+ Tyr+ Lystbg/J

Stock Number:

000494

Availability:

Cryopreserved - Ready for recovery

Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Former Names J.Cg-p+ Tyr+ Lystbg/J    (Changed: 11-FEB-08 )
SJL.Cg-p+ Tyr+ Lystbg    (Changed: 15-DEC-04 )
Type Congenic; Mutant Strain;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Additional information on Congenic nomenclature.
Specieslaboratory mouse
Background Strain SJL/J
Donor Strain Lystbg Oak Ridge irr.; Oca2+ C57BL/6 ?; +Tyr-c C57BL/6 ?
GenerationNE13F50p

Appearance
brown agouti, retinal degeneration, affected
Related Genotype: A/A Lystbg/Lystbg Pde6brd1/Pde6brd1

Description
Mice homozygous for the beige spontaneous mutation (Lystbg) are characterized by a condition that closely resembles Chediak-Higashi disease in man and similar conditions in mink and cattle. Abnormal giant lysosomal granules occur in all tissues with granule-containing cells, including granulocytes, lymphocytes, cells of the liver, kidney, central nervous system, pancreas, and thyroid, and the ducts of most glands; in type II pneumocytes; in mast cells; and in retinal pigment epithelium. Granulocytes from beige homozygous mutant mice mice show defective chemotaxis and reduced bactericidal activity. Beige mice are more susceptible than controls to pneumonitis and to various viral, bacterial, and parasitic infections. Natural killer (NK) cells from beige mice exhibit decreased endogenous cytotoxic activity. Beige mice also have a defective cytotoxic T-cell and cytotoxic antibody response to allogeneic tumor cells. Syngeneic tumor cells grow better in beige mice than in littermate controls, an effect thought to be due to the deficiency of NK cells. Beige mice have platelet storage pool deficiency, leading to a prolonged bleeding time. The immunodeficiency of beige mutant mice has been used, especially in combination with the scid mutation (Prkdcscid), in tissue graft and disease studies.

Control Information

  Control
   000686 SJL/J
 
  Considerations for Choosing Controls

Related Strains

Strains carrying   Lystbg allele
000204   B6.C3Rl-Lystbg/J
000269   SB/LeJ
View Strains carrying   Lystbg     (2 strains)

View Strains carrying   Oca2+     (4 strains)

Strains carrying   Tyr+ allele
000090   129S1/Sv-Oca2+ Tyr+ KitlSl-J/J
005445   A.B6 Tyr+-Cybanmf333/J
005012   A.B6 Tyr+-Myo5ad-l31J/J
002565   A.B6-Tyr+/J
000822   B6 x 129S1/SvEi Oca2+ Tyr+-Vsx2or-J/J
000899   C.B6-Tyr+ Hbbs/J
002281   NFS.C58-Tyr+/J
004304   NOD.CBALs-Tyr+/LtJ
View Strains carrying   Tyr+     (8 strains)

Strains carrying other alleles of Lyst
000604   B6C3 a/A-T(10;13)199H +/+ Lystbg-J/J or Lystbg-2J/J
000509   C3.Cg-Lystbg-2J/J
000629   C57BL/6J-Lystbg-J/J
View Strains carrying other alleles of Lyst     (3 strains)

View Strains carrying other alleles of Oca2     (19 strains)

View Strains carrying other alleles of Tyr     (38 strains)

Additional Web Information

JAX® NOTES, Spring 1991; 445. Why C57BL/6J-bgJ (beige) Mice are not Beige.
JAX® NOTES, Winter 1992; 448. The Beige (BgJ) Mutation.

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms
Chediak-Higashi Syndrome; CHS - Models with phenotypic similarity to human disease where etiologies involve orthologs.1
1 Human genes are associated with this disease. Orthologs of those genes appear in the mouse genotype(s).
View Mammalian Phenotype Terms

Mammalian Phenotype Terms
      assigned by genotype

The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.

Lystbg/Lystbg

        C3H/Rl
  • pigmentation phenotype
  • abnormal eye pigmentation (MGI Ref ID J:29744)
  • diluted coat color (MGI Ref ID J:29744)
  • irregular coat pigmentation (MGI Ref ID J:29744)
  • skin/coat/nails phenotype
  • diluted coat color (MGI Ref ID J:29744)
  • irregular coat pigmentation (MGI Ref ID J:29744)
  • vision/eye phenotype
  • abnormal eye pigmentation (MGI Ref ID J:29744)

Lystbg/Lystbg

        B6.C3Rl-Lystbg
  • tumorigenesis
  • increased incidence of induced tumors (MGI Ref ID J:6302)
  • pigmentation phenotype
  • abnormal melanosome morphology (MGI Ref ID J:5346)
    • enlarged hair follicle melanin granules (MGI Ref ID J:5078)
  • cellular phenotype
  • abnormal lysosome morphology (MGI Ref ID J:29294)
    • accumulation of giant lysosomes in kidney/renal tubule cells (MGI Ref ID J:5590)
  • lysosomal protein accumulation (MGI Ref ID J:5338)
  • hematopoietic system phenotype
  • abnormal eosinophil morphology (MGI Ref ID J:5078)
    • presence of giant granules in cells
  • abnormal lymphocyte morphology (MGI Ref ID J:5078)
    • presence of giant granules in cells
  • abnormal neutrophil morphology (MGI Ref ID J:5078)
    • presence of giant granules in cells
  • immune system phenotype
  • abnormal eosinophil morphology (MGI Ref ID J:5078)
    • presence of giant granules in cells
  • abnormal lymphocyte morphology (MGI Ref ID J:5078)
    • presence of giant granules in cells
  • abnormal neutrophil morphology (MGI Ref ID J:5078)
    • presence of giant granules in cells
  • defective cytotoxic T cell cytolysis (MGI Ref ID J:6692)
  • impaired NK cell cytolysis (MGI Ref ID J:6213)
  • increased susceptibility to parasitic infection (MGI Ref ID J:6946)
  • renal/urinary system phenotype
  • accumulation of giant lysosomes in kidney/renal tubule cells (MGI Ref ID J:5590)
  • skin/coat/nails phenotype
  • enlarged hair follicle melanin granules (MGI Ref ID J:5078)
  • nervous system phenotype
  • abnormal hippocampal mossy fiber morphology (MGI Ref ID J:4978)
  • ectopic Bergmann glia cells (MGI Ref ID J:4978)
  • ectopic Purkinje cell (MGI Ref ID J:4978)
  • ectopic granule cells (MGI Ref ID J:4978)
  • ectopic pyramidal neurons (MGI Ref ID J:4978)
  • behavior/neurological phenotype
  • abnormal vestibuloocular reflex (MGI Ref ID J:29747)
    • mice exhibit an inverted optokinetic nystagmus in response to stimulation of only the temporal retina
    • mice exhibit eye movements with a vertical component in response to horizontally moving, full-field stimuli
  • enhanced behavioral response to xenobiotics (MGI Ref ID J:29294)
    • sleep time is increased in mice exposed to pentobarbital, tribromoethanol, or alphaxalone compared to controls
  • hearing/vestibular/ear phenotype
  • abnormal vestibuloocular reflex (MGI Ref ID J:29747)
    • mice exhibit an inverted optokinetic nystagmus in response to stimulation of only the temporal retina
    • mice exhibit eye movements with a vertical component in response to horizontally moving, full-field stimuli

Lystbg/Lystbg

        B6.C3Rl-Lystbg/J
  • cellular phenotype
  • abnormal lysosome morphology (MGI Ref ID J:6629)
    • light and electron microscopic cytochemistry of cultured fibroblasts shows large dense bodies have an origin through fusion of lysosomes
  • abnormal lysosome physiology (MGI Ref ID J:6801)
    • significant increase in lysosomal enzyme activity of beta-galactosidase and beta-glucuronidase, and to a lesser extent N-acetyl-beta-hexoseaminidase, in kidney extracts
  • immune system phenotype
  • abnormal NK cell physiology (MGI Ref ID J:6801)
    • lower natural killer cell activity
  • respiratory system phenotype
  • abnormal lung development (MGI Ref ID J:149429)
    • impaired respiratory alveologenesis (MGI Ref ID J:149429)
      • alveolar maturation is impaired, resulting in abnormally large alveoli
  • emphysema (MGI Ref ID J:149429)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Lystbg related

Cardiovascular Research
Atherosclerosis

Dermatology Research
Color and White Spotting Defects

Hematological Research
Immunological Defects
Platelet Defects
      platelet storage pool deficiency

Immunology and Inflammation Research
CD Antigens, Antigen Receptors, and Histocompatibility Markers
Immunodeficiency
Intracellular Signaling Molecules

Internal/Organ Research
Kidney Defects
      lysosomal enzyme abnormalities

Metabolism Research

Mouse/Human Gene Homologs
Chediak-Higashi syndrome

Research Tools
Immunology and Inflammation Research
      NK Cell Deficiency

Tyr+ related

Dermatology Research
Color and White Spotting Defects
      oculocutaneous albinism, type I

Mouse/Human Gene Homologs
albinism, tyrosine negative
      wildtype

Genes & Alleles

Gene & Allele Information

 
Allele Symbol Lystbg
Allele Name beige
Allele Type Radiation induced
Common Name(s) 30B/22B; CHS mice; bg;
Strain of OriginC3H/Rl
Gene Symbol and Name Lyst, lysosomal trafficking regulator
Chromosome 13
Gene Common Name(s) Beige; CHS; CHS1; D13Sfk13; DNA segment, Chr 13, Stephen F. Kingsmore 13; beige; bg;
Molecular Note This allele is an insertion of a partial LINE 1 repetitive element into an intron of the gene. The insertion included only the most 3' 1097 bp of the element producing a frameshift mutation resulting in a truncated protein predicted to be missing the last 1442 amino acids. [MGI Ref ID J:33734] [MGI Ref ID J:41243]
 
Allele Symbol Oca2+
Allele Name wild type
Allele Type Not Specified
Gene Symbol and Name Oca2, oculocutaneous albinism II
Chromosome 7
Gene Common Name(s) BEY; BEY1; BEY2; BOCA; D15S12; D7H15S12; D7Icr28RN; D7Nic1; DNA segment, Chr 7, Institute for Cancer Research 28RN; DNA segment, Chr 7, Nicholls 1; DNA segment, Chr 7, human D15S12; EYCL; EYCL2; EYCL3; HCL3; P; PED; SHEP1; p; pink-eyed dilution;
 
Allele Symbol Tyr+
Allele Name wild type
Allele Type Not Applicable
Gene Symbol and Name Tyr, tyrosinase
Chromosome 7
Gene Common Name(s) C; OCA1A; OCAIA; SHEP3; albino; c; skc35; skin/coat color 35;

Genotyping

Genotyping Information

This strain will not have a genotyping protocol or one is not currently available.

Helpful Links

Genotyping resources and troubleshooting

References

References

Additional References

Gallin JI; Bujak JS; Patten E; Wolff SM. 1974. Granulocyte function in the Chediak-Higashi syndrome of mice. Blood 43(2):201-6. [PubMed: 4589319]  [MGI Ref ID J:5405]

Perou CM; Moore KJ; Nagle DL; Misumi DJ; Woolf EA; McGrail SH; Holmgren L; Brody TH; Dussault BJ Jr; Monroe CA; Duyk GM; Pryor RJ; Li L; Justice MJ; Kaplan J. 1996. Identification of the murine beige gene by YAC complementation and positional cloning. Nat Genet 13(3):303-8. [PubMed: 8673129]  [MGI Ref ID J:33734]

Roder JC. 1979. The beige mutation in the mouse. I. A stem cell predetermined impairment in natural killer cell function. J Immunol 123(5):2168-73. [PubMed: 489978]  [MGI Ref ID J:6213]

Schiller NK; Black AS; Bradshaw GP; Bonnet DJ; Curtiss LK. 2004. Participation of macrophages in atherosclerotic lesion morphology in LDLr-/- mice. J Lipid Res 45(8):1398-409. [PubMed: 15175354]  [MGI Ref ID J:91367]

Lystbg related

Ahmed F; Lundin LG; Shire JG. 1989. Lysosomal mutations increase susceptibility to anaesthetics. Experientia 45(11-12):1133-5. [PubMed: 2513223]  [MGI Ref ID J:29294]

Ahmed F; Shire JG. 1985. Lysosomal mutations inhibit lipofuscinosis of the spleen in C57BL mice. J Hered 76(4):311-2. [PubMed: 4031470]  [MGI Ref ID J:7980]

Andoh M; Zhang G; Russell-Lodrigue KE; Shive HR; Weeks BR; Samuel JE. 2007. T Cells Are Essential for Bacterial Clearance, and Gamma Interferon, Tumor Necrosis Factor Alpha, and B Cells Are Crucial for Disease Development in Coxiella burnetii Infection in Mice. Infect Immun 75(7):3245-55. [PubMed: 17438029]  [MGI Ref ID J:122426]

Appelberg R; Castro AG; Gomes S; Pedrosa J; Silva MT. 1995. Susceptibility of beige mice to Mycobacterium avium: role of neutrophils. Infect Immun 63(9):3381-7. [PubMed: 7642266]  [MGI Ref ID J:28292]

Barthold SW; de Souza M. 1995. Exacerbation of Lyme arthritis in beige mice. J Infect Dis 172(3):778-84. [PubMed: 7658072]  [MGI Ref ID J:28297]

Bertin A. 1992. Comparison of susceptibility of inbred and outbred infant mice to Escherichia coli heat-stable enterotoxin STa. Infect Immun 60(8):3117-21. [PubMed: 1639480]  [MGI Ref ID J:2117]

Borges R; Jaen R; Freire F; Gomez JF; Villafruela C; Yanes E. 2001. Morphological and functional characterization of beige mouse adrenomedullary secretory vesicles. Cell Tissue Res 304(1):159-64. [PubMed: 11383882]  [MGI Ref ID J:105112]

Brandt EJ; Elliott RW; Swank RT. 1975. Defective lysosomal enzyme secretion in kidneys of Chediak-Higashi (beige) mice. J Cell Biol 67(3):774-88. [PubMed: 408]  [MGI Ref ID J:5590]

Cavarra E; Martorana PA; de Santi M; Bartalesi B; Cortese S; Gambelli F; Lungarella G. 1999. Neutrophil influx into the lungs of beige mice is followed by elastolytic damage and emphysema. Am J Respir Cell Mol Biol 20(2):264-9. [PubMed: 9922217]  [MGI Ref ID J:53722]

Chi EY; Ignacio E; Lagunoff D. 1978. Mast cell granule formation in the beige mouse. J Histochem Cytochem 26(2):131-7. [PubMed: 624833]  [MGI Ref ID J:5935]

Chow LH. 1993. Studies of virus-induced myocardial injury in mice: value of the scid mutation on different genetic backgrounds and combined with other mutations. Lab Anim Sci 43(2):133-5. [PubMed: 8391609]  [MGI Ref ID J:12476]

Clark EA; Roths JB; Murphy ED; Ledbetter JA; Clagett JA. 1982. The beige (bg) gene influences the development of autoimmune disease in SB/Le male mice. In: NK Cells and Other Natural Effector Cells. Academic Press, New York.  [MGI Ref ID J:30716]

Clark EA; Shultz LD; Pollack SB. 1981. Mutations in mice that influence natural killer (NK) cell activity. Immunogenetics 12(5-6):601-13. [PubMed: 6971254]  [MGI Ref ID J:6485]

Defosse DL; Duray PH; Johnson RC. 1992. The NIH-3 immunodeficient mouse is a model for Lyme borreliosis myositis and carditis. Am J Pathol 141(1):3-10. [PubMed: 1632468]  [MGI Ref ID J:1423]

Dominique V; Francis L. 1995. Interactions of the scid or beige mutations with the viable motheaten mutation. Autoimmunity 22(4):199-207. [PubMed: 8781712]  [MGI Ref ID J:33985]

Elin RJ; Edelin JB; Wolff SM. 1974. Infection and immunoglobulin concentrations in Chediak-Higashi mice. Infect Immun 10(1):88-91. [PubMed: 4601767]  [MGI Ref ID J:5471]

Enriquez FJ; Sterling CR. 1991. Cryptosporidium infections in inbred strains of mice. J Protozool 38(6):100S-102S. [PubMed: 1818124]  [MGI Ref ID J:598]

Feith GW; Assmann KJ; Bogman MJ; van Gompel AP; Schalkwijk J; Koene RA. 1993. Lack of albuminuria in the early heterologous phase of anti-GBM nephritis in beige mice. Kidney Int 43(4):824-7. [PubMed: 8479118]  [MGI Ref ID J:12891]

Fernandez NC; Lozier A; Flament C; Ricciardi-Castagnoli P; Bellet D; Suter M; Perricaudet M; Tursz T; Maraskovsky E; Zitvogel L. 1999. Dendritic cells directly trigger NK cell functions: cross-talk relevant in innate anti-tumor immune responses in vivo. Nat Med 5(4):405-11. [PubMed: 10202929]  [MGI Ref ID J:54135]

Galli SJ; Hammel I. 1984. Unequivocal delayed hypersensitivity in mast cell-deficient and beige mice. Science 226(4675):710-3. [PubMed: 6494907]  [MGI Ref ID J:127346]

Gallin JI; Bujak JS; Patten E; Wolff SM. 1974. Granulocyte function in the Chediak-Higashi syndrome of mice. Blood 43(2):201-6. [PubMed: 4589319]  [MGI Ref ID J:5405]

Gallo-Hendrikx E; Percy D; Copps J; McKeown B; Quinton M; McMillan I; Croy BA; Wildeman AG. 1999. Evaluation of three lines of immunodeficient mice for the study of spontaneous metastatic tumors. APMIS 107(2):245-56. [PubMed: 10225324]  [MGI Ref ID J:54114]

Guo H; Sekiguchi M; Shimai K. 1992. Cytoarchitectonic abnormalities in cerebellum and hippocampal formation of beige mutant mouse. Tokai J Exp Clin Med 17(1):53-61. [PubMed: 1523694]  [MGI Ref ID J:4978]

Haliotis T; Ball JK; Dexter D; Roder JC. 1985. Spontaneous and induced primary oncogenesis in natural killer (NK)-cell-deficient beige mutant mice. Int J Cancer 35(4):505-13. [PubMed: 2985510]  [MGI Ref ID J:80649]

Harkness RE; Guimond MJ; McBey BA; Klein MH; Percy DH; Croy BA. 1993. Branhamella catarrhalis pathogenesis in SCID and SCID/beige mice. Brief report. APMIS 101(10):805-10. [PubMed: 8267959]  [MGI Ref ID J:16050]

Hearing VJ; Phillips P; Lutzner MA. 1973. The fine structure of melanogenesis in coat color mutants of the mouse. J Ultrastruct Res 43(1):88-106. [PubMed: 4634048]  [MGI Ref ID J:5346]

Hua C; Chang B; Ma B-L; Li Y; Wang G. 1992. Reduction of lymphokine-activated killer cell activity by the introduction of the beige gene into SCID mice ILAR News 34(1-2):S15-S16.  [MGI Ref ID J:2627]

Ishigaki Y; Hayakawa J; Hashimoto N; Nikaido H; Nikaido O. 1996. New immunodeficient mouse strains bred by introducing beige and xid mutations into the KSN nude strain. (Correction: 1996 Dec;46(6):691) Lab Anim Sci 46(4):418-24. [PubMed: 8872993]  [MGI Ref ID J:36125]

Ishigaki Y; Yasuda K; Hashimoto N; Hayakawa J; Hiai H; Nikaido O. 1998. A comparison of UVB-carcinogenesis between nude mice and nude beige mice. J Radiat Res (Tokyo) 39(2):119-27. [PubMed: 9735600]  [MGI Ref ID J:52659]

Ishigaki Y; Yasuda K; Hashimoto N; Nikaido H; Nikaido O; Hayakawa JI. 1998. Enhanced human tumor cell transplantability in a new congenic immunodeficient mouse; KSN-BNX. Folia Microbiol (Praha) 43(5):493-4. [PubMed: 9821307]  [MGI Ref ID J:52313]

Jensen BL; Rasch R; Nyengaard JR; Skott O. 1997. Giant renin secretory granules in beige mouse renal afferent arterioles. Cell Tissue Res 288(2):399-406. [PubMed: 9082976]  [MGI Ref ID J:41539]

Johnson LL; Sayles PC. 1995. Strong cytolytic activity of natural killer cells is neither necessary nor sufficient for preimmune resistance to Toxoplasma gondii infection. Nat Immun 14(4):209-15. [PubMed: 8696010]  [MGI Ref ID J:113057]

Jones-Carson J; Vazquez-Torres A; Balish E. 1995. Defective killing of Candida albicans hyphae by neutrophils from beige mice. J Infect Dis 171(6):1664-7. [PubMed: 7769315]  [MGI Ref ID J:25930]

Kaido T; Gresser I; Maury C; Maunoury MT; Vignaux F; Belardelli F. 1993. Sensitized T lymphocytes render DBA/2 beige mice responsive to IFN alpha/beta therapy of Friend erythroleukemia visceral metastases. Int J Cancer 54(3):475-81. [PubMed: 8509222]  [MGI Ref ID J:12190]

Karre K; Klein GO; Kiessling R; Klein G; Roder JC. 1980. Low natural in vivo resistance to syngeneic leukaemias in natural killer-deficient mice. Nature 284(5757):624-6. [PubMed: 7366734]  [MGI Ref ID J:6302]

Keil M; Lungarella G; Cavarra E; van Even P; Martorana PA. 1996. A scanning electron microscopic investigation of genetic emphysema in tight-skin, pallid, and beige mice, three different C57 BL/6J mutants. Lab Invest 74(2):353-62. [PubMed: 8780155]  [MGI Ref ID J:31735]

Kelly EM. 1957. Beige, bg Mouse News Lett 16:36.  [MGI Ref ID J:29744]

Kirkpatrick CE; Farrell JP. 1982. Leishmaniasis in beige mice. Infect Immun 38(3):1208-16. [PubMed: 6218091]  [MGI Ref ID J:6946]

Kisucka J; Butterfield CE; Duda DG; Eichenberger SC; Saffaripour S; Ware J; Ruggeri ZM; Jain RK; Folkman J; Wagner DD. 2006. Platelets and platelet adhesion support angiogenesis while preventing excessive hemorrhage. Proc Natl Acad Sci U S A 103(4):855-60. [PubMed: 16418262]  [MGI Ref ID J:105659]

Kuntz L; Jachez B; Roman D; Loor F. 1993. Modulation of adoptively transferred viable motheaten pathology in sublethally irradiated normal recipient mice by normal hematopoietic cells. Cell Immunol 146(1):215-21. [PubMed: 8093859]  [MGI Ref ID J:3800]

Lane PW; Murphy ED. 1972. Susceptibility to spontaneous pneumonitis in an inbred strain of beige and satin mice. Genetics 72(3):451-60. [PubMed: 4643821]  [MGI Ref ID J:5311]

Lode HN; Xiang R; Pertl U; Forster E; Schoenberger SP; Gillies SD; Reisfeld RA. 2000. Melanoma immunotherapy by targeted IL-2 depends on CD4(+) T-cell help mediated by CD40/CD40L interaction. J Clin Invest 105(11):1623-30. [PubMed: 10841521]  [MGI Ref ID J:62762]

Lu L; Ghose AK; Quail MR; Albom MS; Durkin JT; Holskin BP; Angeles TS; Meyer SL; Ruggeri BA; Cheng M. 2009. ALK mutants in the kinase domain exhibit altered kinase activity and differential sensitivity to small molecule ALK inhibitors. Biochemistry 48(16):3600-9. [PubMed: 19249873]  [MGI Ref ID J:149248]

Lutzner MA; Lowrie CT; Jordan HW. 1967. Giant granules in leukocytes of the beige mouse. J Hered 58(6):299-300. [PubMed: 5590154]  [MGI Ref ID J:5078]

Maruo K; Shimamura K; Hioki K; Itoh M; Ueyama Y; Tamaoki N. 1993. Role of X-linked immunodeficiency (xid) and NK activity in rejection of human tumor xenotransplants in nude mice. APMIS 101(5):345-52. [PubMed: 8329195]  [MGI Ref ID J:14379]

Mathiasen JR; Raffa RB; Vaught JL. 1987. C57BL/6J-bgJ (beige) mice: differential sensitivity in the tail flick test to centrally administered mu- and delta-opioid receptor agonists. Life Sci 40(20):1989-94. [PubMed: 3033418]  [MGI Ref ID J:29746]

McGarry MP; Reddington M; Novak EK; Swank RT. 1999. Survival and lung pathology of mouse models of Hermansky-Pudlak syndrome and Chediak-Higashi syndrome. Proc Soc Exp Biol Med 220(3):162-8. [PubMed: 10193444]  [MGI Ref ID J:53228]

McGarry RC; Walker R; Roder JC. 1984. The cooperative effect of the satin and beige mutations in the suppression of NK and CTL activities in mice. Immunogenetics 20(5):527-34. [PubMed: 6334024]  [MGI Ref ID J:7649]

McLeod R; Estes RG; Mack DG; Cohen H. 1984. Immune response of mice to ingested Toxoplasma gondii: a model of toxoplasma infection acquired by ingestion. J Infect Dis 149(2):234-44. [PubMed: 6699433]  [MGI Ref ID J:39992]

Mosier DE; Stell KL; Gulizia RJ; Torbett BE; Gilmore GL. 1993. Homozygous scid/scid;beige/beige mice have low levels of spontaneous or neonatal T cell-induced B cell generation. J Exp Med 177(1):191-4. [PubMed: 8418200]  [MGI Ref ID J:3479]

Murphy ED; Roths JB. 1978. Purkinje cell degeneration, a late effect of beige mutations in mice Jackson Lab Ann Rep 49:108-9.  [MGI Ref ID J:15166]

Mutwiri G K; Kosecka U; Benjamin M; Rosendal S; Perdue M; Butler D G. 2001. Mycobacterium avium subspecies paratuberculosis triggers intestinal pathophysiologic changes in beige/scid mice. Comp Med 51(6):538-44. [PubMed: 11924817]  [MGI Ref ID J:73720]

Nakagawa R; Nagafune I; Tazunoki Y; Ehara H; Tomura H; Iijima R; Motoki K; Kamishohara M; Seki S. 2001. Mechanisms of the antimetastatic effect in the liver and of the hepatocyte injury induced by alpha-galactosylceramide in mice. J Immunol 166(11):6578-84. [PubMed: 11359810]  [MGI Ref ID J:69484]

Nonoyama S; Smith FO; Bernstein ID; Ochs HD. 1993. Strain-dependent leakiness of mice with severe combined immune deficiency. J Immunol 150(9):3817-24. [PubMed: 8473734]  [MGI Ref ID J:4610]

Novak EK; Hui SW; Swank RT. 1984. Platelet storage pool deficiency in mouse pigment mutations associated with seven distinct genetic loci. Blood 63(3):536-44. [PubMed: 6696991]  [MGI Ref ID J:7327]

Novak EK; McGarry MP; Swank RT. 1985. Correction of symptoms of platelet storage pool deficiency in animal models for Chediak-Higashi syndrome and Hermansky-Pudlak syndrome. Blood 66(5):1196-201. [PubMed: 3902123]  [MGI Ref ID J:8056]

Ohsugi T; Kiuchi Y; Shimoda K; Oguri S; Maejima K. 1996. Translocation of bacteria from the gastrointestinal tract in immunodeficient mice. Lab Anim 30(1):46-50. [PubMed: 8709573]  [MGI Ref ID J:31261]

Oliver C; Essner E. 1973. Distribution of anomalous lysosomes in the beige mouse: a homologue of Chediak-Higashi syndrome. J Histochem Cytochem 21(3):218-28. [PubMed: 4697831]  [MGI Ref ID J:5338]

Oliver C; Essner E. 1975. Formation of anomalous lysosomes in monocytes, neutrophils, and eosinophils from bone marrow of mice with Chediak-Higashi syndrome. Lab Invest 32(1):17-27. [PubMed: 1113502]  [MGI Ref ID J:5514]

Oliver JM. 1976. Impaired microtubule function correctable by cyclic GMP and cholinergic agonists in the Chediak-Higashi syndrome. Am J Pathol 85(2):395-418. [PubMed: 187062]  [MGI Ref ID J:5728]

Orn A; Hakansson EM; Gidlund M; Ramstedt U; Axberg I; Wigzell H; Lundin LG. 1982. Pigment mutations in the mouse which also affect lysosomal functions lead to suppressed natural killer cell activity. Scand J Immunol 15(3):305-10. [PubMed: 7089489]  [MGI Ref ID J:6801]

Pak MW; Giolli RA; Pinto LH; Mangini NJ; Gregory KM; Vanable JW Jr. 1987. Retinopretectal and accessory optic projections of normal mice and the OKN-defective mutant mice beige, beige-J, and pearl. J Comp Neurol 258(3):435-46. [PubMed: 3584547]  [MGI Ref ID J:29747]

Percy DH; Auger DC; Croy BA. 1994. Signs and lesions of experimental Sendai virus infection in two genetically distinct strains of SCID/beige mice. Vet Pathol 31(1):67-73. [PubMed: 8140728]  [MGI Ref ID J:17913]

Percy DH; Barta JR. 1993. Spontaneous and experimental infections in scid and scid/beige mice. Lab Anim Sci 43(2):127-32. [PubMed: 8320959]  [MGI Ref ID J:4752]

Perou CM; Kaplan J. 1993. Complementation analysis of Chediak-Higashi syndrome: the same gene may be responsible for the defect in all patients and species. Somat Cell Mol Genet 19(5):459-68. [PubMed: 8291023]  [MGI Ref ID J:16651]

Perou CM; Leslie JD; Green W; Li L; Ward DM; Kaplan J. 1997. The Beige/Chediak-Higashi syndrome gene encodes a widely expressed cytosolic protein. J Biol Chem 272(47):29790-4. [PubMed: 9368050]  [MGI Ref ID J:44170]

Perou CM; Moore KJ; Nagle DL; Misumi DJ; Woolf EA; McGrail SH; Holmgren L; Brody TH; Dussault BJ Jr; Monroe CA; Duyk GM; Pryor RJ; Li L; Justice MJ; Kaplan J. 1996. Identification of the murine beige gene by YAC complementation and positional cloning. Nat Genet 13(3):303-8. [PubMed: 8673129]  [MGI Ref ID J:33734]

Perou CM; Pryor RJ; Naas TP; Kaplan J. 1997. The bg allele mutation is due to a LINE1 element retrotransposition. Genomics 42(2):366-8. [PubMed: 9192864]  [MGI Ref ID J:41243]

Pierce EM; Carpenter K; Jakubzick C; Kunkel SL; Flaherty KR; Martinez FJ; Hogaboam CM. 2007. Therapeutic targeting of CC ligand 21 or CC chemokine receptor 7 abrogates pulmonary fibrosis induced by the adoptive transfer of human pulmonary fibroblasts to immunodeficient mice. Am J Pathol 170(4):1152-64. [PubMed: 17392156]  [MGI Ref ID J:120124]

Pope BL; Chourmouzis E; MacIntyre JP; Lee S; Goodman MG. 1994. Murine strain variation in the natural killer cell and proliferative responses to the immunostimulatory compound 7-allyl-8-oxoguanosine: role of cytokines. Cell Immunol 159(2):194-210. [PubMed: 7994754]  [MGI Ref ID J:21893]

Prueitt JL; Chi EY; Lagunoff D. 1978. Pulmonary surface-active materials in the Chediak-Higashi syndrome. J Lipid Res 19(4):410-5. [PubMed: 580786]  [MGI Ref ID J:5992]

Rasmussen KR; Healey MC. 1992. Experimental Cryptosporidium parvum infections in immunosuppressed adult mice. Infect Immun 60(4):1648-52. [PubMed: 1548087]  [MGI Ref ID J:37919]

Robison WG Jr; Kuwabara T. 1976. Light-induced alterations of retinal pigment epithelium in black, albino, and beige mice. Exp Eye Res 22(5):549-57. [PubMed: 1278263]  [MGI Ref ID J:5656]

Roder JC. 1979. The beige mutation in the mouse. I. A stem cell predetermined impairment in natural killer cell function. J Immunol 123(5):2168-73. [PubMed: 489978]  [MGI Ref ID J:6213]

Roths JB; Murphy ED. 1982. The beige mutation retards the progression of autoimmune disease. Jackson Lab Ann Rep 53:65.  [MGI Ref ID J:13373]

Runkel F; Bussow H; Seburn KL; Cox GA; Ward DM; Kaplan J; Franz T. 2006. Grey, a novel mutation in the murine Lyst gene, causes the beige phenotype by skipping of exon 25. Mamm Genome 17(3):203-10. [PubMed: 16518687]  [MGI Ref ID J:106442]

Saxena RK; Saxena QB; Adler WH. 1982. Defective T-cell response in beige mutant mice. Nature 295(5846):240-1. [PubMed: 6977094]  [MGI Ref ID J:6692]

Schito ML; Barta JR. 1997. Nonspecific immune responses and mechanisms of resistance to Eimeria papillata infections in mice. Infect Immun 65(8):3165-70. [PubMed: 9234770]  [MGI Ref ID J:41839]

Shellam GR; Allan JE; Papadimitriou JM; Bancroft GJ. 1981. Increased susceptibility to cytomegalovirus infection in beige mutant mice. Proc Natl Acad Sci U S A 78(8):5104-8. [PubMed: 6272291]  [MGI Ref ID J:6646]

Shibata S; Asano T; Ogura A; Hashimoto N; Hayakawa J; Uetsuka K ; Nakayama H ; Doi K. 1997. SCID-bg mice as xenograft recipients. Lab Anim 31(2):163-8. [PubMed: 9175014]  [MGI Ref ID J:40569]

St Amand W; Cupp MB. 1958. sa and bg linked Mouse News Lett 19:38.  [MGI Ref ID J:196]

Starcher B; O'Neal P; Granstein RD; Beissert S. 1996. Inhibition of neutrophil elastase suppresses the development of skin tumors in hairless mice. J Invest Dermatol 107(2):159-63. [PubMed: 8757756]  [MGI Ref ID J:34446]

Starcher B; Williams I. 1989. The beige mouse: role of neutrophil elastase in the development of pulmonary emphysema. Exp Lung Res 15(5):785-800. [PubMed: 2806196]  [MGI Ref ID J:149728]

Stephenson DA; Glenister PH; Hornby JE. 1985. Site of beige (bg) and leaden (ln) pigment gene expression determined by recombinant embryonic skin grafts and aggregation mouse chimaeras employing sash (Wsh) homozygotes. Genet Res 46(2):193-205. [PubMed: 3910518]  [MGI Ref ID J:8167]

Sundberg JP (ed.). 1994. . In: Handbook of Mouse Mutations with Skin and Hair Abnormalities: Animal Models and Biomedical Tools. CRC Press, Boca Raton.  [MGI Ref ID J:30359]

Sundberg JP; Sundberg BA; Beamer WG. 1997. Comparison of chemical carcinogen skin tumor induction efficacy in inbred, mutant, and hybrid strains of mice: Morphologic variations of induced tumors and absence of a papillomavirus cocarcinogen. Mol Carcinog 20(1):19-32. [PubMed: 9328433]  [MGI Ref ID J:43880]

Swank RT; Brandt EJ. 1978. Turnover of kidney beta-glucuronidase in normal and Chediak-Higashi (beige) mice. Am J Pathol 92(3):755-69. [PubMed: 686157]  [MGI Ref ID J:6027]

Takeuchi K; Toyohara H; Sakaguchi M. 2000. A hyperosmotic stress-induced mRNA of carp cell encodes Na(+)- and Cl(-)-dependent high affinity taurine transporter. Biochim Biophys Acta 1464(2):219-30. [PubMed: 10727609]  [MGI Ref ID J:61152]

Takeuchi K; Wood H; Swank RT. 1986. Lysosomal elastase and cathepsin G in beige mice. Neutrophils of beige (Chediak-Higashi) mice selectively lack lysosomal elastase and cathepsin G. J Exp Med 163(3):665-77. [PubMed: 3512758]  [MGI Ref ID J:8207]

Talmadge JE; Meyers KM; Prieur DJ; Starkey JR. 1980. Role of NK cells in tumour growth and metastasis in beige mice. Nature 284(5757):622-4. [PubMed: 7366733]  [MGI Ref ID J:6301]

Tanaka E; Yuba Y; Sato A; Kuze F. 1994. Effects of the beige mutation on respiratory tract infection with Pseudomonas aeruginosa in mice. Exp Lung Res 20(4):351-66. [PubMed: 7988496]  [MGI Ref ID J:20488]

Tang X; Yamanaka S; Miyagi Y; Nagashima Y; Nakatani Y. 2005. Lung pathology of pale ear mouse (model of Hermansky-Pudlak syndrome 1) and beige mouse (model of Chediak-Higashi syndrome): severity of giant lamellar body degeneration of type II pneumocytes correlates with interstitial inflammation. Pathol Int 55(3):137-43. [PubMed: 15743322]  [MGI Ref ID J:110157]

Tiberghien F; Ceredig R; Loor F. 1994. Influence of the lpr environment on the lymph node cell phenotypes in C57BL/6 nubg and nulpr chimeras. Immunology 83(4):552-61. [PubMed: 7875735]  [MGI Ref ID J:21826]

Tischfield JA; Ruddle FH. 1974. Assignment of the gene for adenine phosphoribosyltransferase to human chromosome 16 by mouse-human somatic cell hybridization. Proc Natl Acad Sci U S A 71(1):45-9. [PubMed: 4129802]  [MGI Ref ID J:5409]

Verzi MP; Khan AH; Ito S; Shivdasani RA. 2008. Transcription factor foxq1 controls mucin gene expression and granule content in mouse stomach surface mucous cells. Gastroenterology 135(2):591-600. [PubMed: 18558092]  [MGI Ref ID J:141778]

Waggie KS; Wu-Owens J; Hollifield V; Hansen CT. 1992. Lymphoblastic lymphoma in a colony of N:NIH(S)-bg-nu-xid mice. Lab Anim Sci 42(4):375-7. [PubMed: 1434498]  [MGI Ref ID J:2184]

Warner T; Balish E. 1995. Pulmonary alveolar proteinosis. A spontaneous and inducible disease in immunodeficient germ-free mice. Am J Pathol 146(4):1017-24. [PubMed: 7717446]  [MGI Ref ID J:24415]

Whitney PL; Starcher B; Brittain C. 1992. Soluble beta-galactoside specific lectin is developmentally regulated in lungs of neonatal black mice and beige mice. Exp Lung Res 18(4):553-61. [PubMed: 1516572]  [MGI Ref ID J:2387]

Willingham MC; Spicer SS; Vincent RA Jr. 1981. The origin and fate of large dense bodies in beige mouse fibroblasts. Lysosomal fusion and exocytosis. Exp Cell Res 136(1):157-68. [PubMed: 6170520]  [MGI Ref ID J:6629]

Winslow GM; Yager E; Shilo K; Collins DN; Chu FK. 1998. Infection of the laboratory mouse with the intracellular pathogen Ehrlichia chaffeensis. Infect Immun 66(8):3892-9. [PubMed: 9673277]  [MGI Ref ID J:48876]

Yoshizawa M; Okada T; Morikawa Y; Sasaki F; Kiso Y. 1994. Murine granulated metrial gland cell population in beige (bg/bg) and SCID (scid/scid) genotypes. J Vet Med Sci 56(2):415-6. [PubMed: 8075241]  [MGI Ref ID J:21177]

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Oca2+ related

Mouse Genome Informatics (MGI). 2006. Information obtained from The RIKEN BioResource Center :.  [MGI Ref ID J:104881]

Tyr+ related

Lossie AC; Nakamura H; Thomas SE; Justice MJ. 2005. Mutation of l7Rn3 shows that Odz4 is required for mouse gastrulation. Genetics 169(1):285-99. [PubMed: 15489520]  [MGI Ref ID J:96673]

Miller DA; Dev VG; Tantravahi R; Miller OJ; Schiffman MB; Yates RA; Gluecksohn-Waelsch S. 1974. Cytological detection of the c-25H deletion involving the albino (c) locus on chromosome 7 in the mouse. Genetics 78(3):905-10. [PubMed: 4141683]  [MGI Ref ID J:5520]

Sweet HO. 1987. Acromelanic (c<a>) Mouse News Lett 78:56.  [MGI Ref ID J:14994]

Health & husbandry

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Price (US dollars $)
Cryorecovery Fee $1900.00
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At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Additional Supply Details

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Price (US dollars $)
Cryorecovery Fee $2470.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Additional Supply Details

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Standard SupplyCryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information.
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  • Cryorecovery - Standard.
    We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. The total number of animals provided, their gender and genotype will vary. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 13 and 16 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
    Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

  • Genomic DNA is available for this strain from the Mouse DNA Resource.

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   000686 SJL/J
 
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"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

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