Strain Name:

J.Cg-Oca2+ Tyr+ Lystbg/J

Stock Number:

000494

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Availability:

Cryopreserved - Ready for recovery

Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Former Names J.Cg-p+ Tyr+ Lystbg/J    (Changed: 11-FEB-08 )
SJL.Cg-p+ Tyr+ Lystbg    (Changed: 15-DEC-04 )
Type Congenic; Mutant Strain;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Additional information on Congenic nomenclature.
Specieslaboratory mouse
Background Strain SJL/J
Donor Strain Lystbg Oak Ridge irr.; Oca2+ C57BL/6 ?; +Tyr-c C57BL/6 ?
GenerationNE13F50p
Generation Definitions

Appearance
brown agouti, retinal degeneration, affected
Related Genotype: A/A Lystbg/Lystbg Pde6brd1/Pde6brd1

Description
Mice homozygous for the beige spontaneous mutation (Lystbg) are characterized by a condition that closely resembles Chediak-Higashi disease in man and similar conditions in mink and cattle. Abnormal giant lysosomal granules occur in all tissues with granule-containing cells, including granulocytes, lymphocytes, cells of the liver, kidney, central nervous system, pancreas, and thyroid, and the ducts of most glands; in type II pneumocytes; in mast cells; and in retinal pigment epithelium. Granulocytes from beige homozygous mutant mice mice show defective chemotaxis and reduced bactericidal activity. Beige mice are more susceptible than controls to pneumonitis and to various viral, bacterial, and parasitic infections. Natural killer (NK) cells from beige mice exhibit decreased endogenous cytotoxic activity. Beige mice also have a defective cytotoxic T-cell and cytotoxic antibody response to allogeneic tumor cells. Syngeneic tumor cells grow better in beige mice than in littermate controls, an effect thought to be due to the deficiency of NK cells. Beige mice have platelet storage pool deficiency, leading to a prolonged bleeding time. The immunodeficiency of beige mutant mice has been used, especially in combination with the scid mutation (Prkdcscid), in tissue graft and disease studies.

Control Information

  Control
   000686 SJL/J
 
  Considerations for Choosing Controls

Related Strains

Strains carrying   Lystbg allele
000204   B6.C3Rl-Lystbg/J
000269   SB/LeJ
010968   SB;C3Sn-Lrp4mdig-2J/GrsrJ
View Strains carrying   Lystbg     (3 strains)

View Strains carrying   Oca2+     (4 strains)

Strains carrying   Tyr+ allele
000090   129S1/Sv-Oca2+ Tyr+ KitlSl-J/J
005445   A.B6 Tyr+-Cybanmf333/J
005012   A.B6 Tyr+-Myo5ad-l31J/J
002565   A.B6-Tyr+/J
000822   B6 x 129S1/SvEi Oca2+ Tyr+-Vsx2or-J/J
000899   C.B6-Tyr+ Hbbs/J
002281   NFS.C58-Tyr+/J
004304   NOD.CBALs-Tyr+/LtJ
View Strains carrying   Tyr+     (8 strains)

Strains carrying other alleles of Lyst
000604   B6C3 a/A-T(10;13)199H +/+ Lystbg-J/J or Lystbg-2J/J
000509   C3.Cg-Lystbg-2J/J
000629   C57BL/6J-Lystbg-J/J
View Strains carrying other alleles of Lyst     (3 strains)

View Strains carrying other alleles of Oca2     (18 strains)

Strains carrying other alleles of Tyr
000091   129T1/Sv-Oca2+ Tyrc-ch Dnd1Ter/J
001017   AKXD10/TyJ
000765   AKXD13/TyJ
000954   AKXD15/TyJ
000958   AKXD16/TyJ
001093   AKXD18/TyJ
001062   AKXD21/TyJ
000947   AKXD22/TyJ
000969   AKXD24/TyJ
000777   AKXD6/TyJ
000763   AKXD9/TyJ
000409   B10.129P-H1b Hbbd Tyrc Ea7a/(5M)oSnJ
000418   B10.129P-H1b Tyrc Hbbd/(5M)nSnJ
000432   B10.C-H1b Hbbd Tyrc/(41N)SnJ
000580   B10.D2/nSn-Tyrc-4J/J
000578   B6 x STOCK Tyrc-ch Bmp5se +/+ Myo6sv/J
017614   B6(Cg)-Tyrc-2J Tg(UBC-mCherry)1Phbs/J
000058   B6(Cg)-Tyrc-2J/J
008647   B6.129P2(Cg)-Trpa1tm1.1Kykw Tyrc-2J/J
000383   B6.C-Tyrc H1b Hbbd/ByJ
013590   B6.Cg-Braftm1Mmcm Ptentm1Hwu Tg(Tyr-cre/ERT2)13Bos/BosJ
003819   B6.Cg-Per2tm1Brd Tyrc-Brd/J
023429   B6.Cg-Tyrc-2J Cdkn1atm1Hpw/J
007484   B6.Cg-Tyrc-2J Tg(Tyr)3412ARpw Tg(Sry-EGFP)92Ei/EiJ
000035   B6.Cg-Tyrc-J/J
000104   B6.Cg-Tyrc-h/J
005349   B6.Cg-awag Tyrc-2J/GrsrJ
012328   B6.Cg-Tg(Tyr-cre/ERT2)13Bos/J
000054   B6.D2-Tyrc-p/J
023428   B6;129X1-Tyrc-2J Cdkn1atm2Hpw/J
000339   C3H/HeJ-Tyrc-9J/J
001294   C3H/HeJ-Tyrc-a/J
001002   C57BL/10SnJ-Tyrc-11J/J
021999   C57BL/6NJ-Tyrem3J/GrsrJ
012257   CB6-Tg(Tyr-TAg)BJjw/Mmjax
001006   CBA/J-Tyrc-10J/J
000657   CE/J
000619   FS/EiJ
004624   FVB.129P2-Pde6b+ Tyrc-ch Fmr1tm1Cgr/J
004828   FVB.129P2-Pde6b+ Tyrc-ch/AntJ
007483   FVB.Cg-Tg(Tyr)3412ARpw Tg(Sry-EGFP)92Ei/EiJ
000271   SH1/LeJ
001759   STOCK A Tyrc Sha/J
000306   STOCK Dll3pu + Tyrc-ch/+ Oca2p Tyrc-ch/J
018129   STOCK Fah1R Tyrc/RJ
000006   STOCK Hk Tyrc/J
014173   STOCK Omptm1.1(COP4*/EYFP)Tboz/J
000206   STOCK a/a Tyrc-h/J
View Strains carrying other alleles of Tyr     (48 strains)

Additional Web Information

JAX® NOTES, Spring 1991; 445. Why C57BL/6J-bgJ (beige) Mice are not Beige.
JAX® NOTES, Winter 1992; 448. The Beige (BgJ) Mutation.

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- Model with phenotypic similarity to human disease where etiologies involve orthologs. Human genes are associated with this disease. Orthologs of those genes appear in the mouse genotype(s).
Chediak-Higashi Syndrome; CHS
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

Lystbg/Lystbg

        B6.C3Rl-Lystbg
  • tumorigenesis
  • altered tumor susceptibility
    • a tumor line modified to be sensitive to NK cytotoxicity transplanted in mutants results in increased growth rate, faster induction time and an increased metastatic capability of the tumor   (MGI Ref ID J:6301)
    • increased incidence of induced tumors
      • mutants transplanted with virally and chemically induced leukemias develop palpable, progressively growing tumors faster and at a higher frequency than heterozygous controls   (MGI Ref ID J:6302)
  • pigmentation phenotype
  • abnormal melanocyte morphology
    • all mice display giant, irregular melanin granules in retinal and choroidal melanocytes; not observed in control mice   (MGI Ref ID J:5078)
    • abnormal melanosome morphology
      • melanosomes are obviously enlarged and often aggregated   (MGI Ref ID J:5338)
      • unlike in control mice where mature eumelanin granules from skin, hair and eye are small, ovoid, deeply pigmented and 1-2 micra in diameter, giant melanin granules present in mutant mice are highly irregular and 2-10 micra in diameter   (MGI Ref ID J:5078)
      • abnormal hair shaft melanin granule shape
        • all mice display giant and irregular melanin granules in the medulla and cortex of hairs; not observed in control mice   (MGI Ref ID J:5078)
  • cellular phenotype
  • abnormal lysosome morphology
    • abnormal lysosomes with high levels of acid phospahatse activity are detected in 15 of 23 tissues examined, including the liver, kidney, pancreas, cerebral cortex, cerebellum, spinal cord, bone marrow, peripheral blood, jejunum, as well as the thyroid, adrenal, gastic, lacrimal, submaxillary glands and sweat glands of the footpad   (MGI Ref ID J:5338)
    • anomalous lysosomes are enlarged, often more variable in size and shape and show a tendency to aggregate   (MGI Ref ID J:5338)
    • the extent of anomaly varies from one tissue to another and within cells of a given tissue, ranging from extensive enlargement and aggregation of lysosomes in liver to a slight increase in size in sweat glands of the footpad   (MGI Ref ID J:5338)
    • the most striking alterations occur in liver parenchymal cells, kidney proximal tubule cells, Purkinje cells of cerebellum, and granulocytes of bone marrow and peripheral blood; no acid phosphatase activity was detected in melanocytes of the eye and skin where melanin granules have not been established as lysosomes   (MGI Ref ID J:5338)
    • electron microscopy of liver and kidney revealed enlarged lysosomes containing numerous lipid-like inclusions   (MGI Ref ID J:5338)
    • no alterations in lysosomal morphology are detected in striated muscle, duodenum, esophagus, epididymis, spleen or spleen node   (MGI Ref ID J:5338)
    • mutants exhibit fusion of newly formed lysosomes in the promocytes and neutrophilic progranulocytes and in mature monocytes, neutrophils, and eosinophils, resulting in fewer but greatly enlarged lysosomes   (MGI Ref ID J:5514)
    • accumulation of giant lysosomes in kidney/renal tubule cells
      • androgen-stimulated mutants exhibit an accumulation of giant glucuronidase-containing lysosomes in tubule cells near the croticomedullary boundary of the kidney   (MGI Ref ID J:5590)
  • decreased lysosomal enzyme secretion
    • mutants secrete fewer units of glucuronidase, beta-galactosidase, and hexosaminidase than controls   (MGI Ref ID J:5590)
    • androgen-treated mutants secrete only 1/3-1/4 as much of the above lysosomal enzymes as controls   (MGI Ref ID J:5590)
  • lysosomal protein accumulation
    • androgen-stimulated mutants exhibit an accumulation of the lysosomal enzymes, beta-glucuronidase, beta-galactosidase, and N-acetyl-beta-D-glucosaminidase (hexosaminidase) in the kidneys, indicating defective process of extruding lysosomal enzymes through the plasma membrane of kidney tubule cells   (MGI Ref ID J:5590)
  • hematopoietic system phenotype
  • abnormal eosinophil morphology
    • all mice display giant granules in eosinophils from peripheral blood and bone marrow; not observed in control mice   (MGI Ref ID J:5078)
    • giant granules are found in a small percentage of cells, usually only 1 or 2 within a cell   (MGI Ref ID J:5078)
    • giant granules are highly irregular and contain excessive numbers of clumped "crystalloids"   (MGI Ref ID J:5078)
  • abnormal lymphocyte morphology
    • all mice display giant granules in lymphocytes from peripheral blood and bone marrow, with an inner round density; not observed in control mice   (MGI Ref ID J:5078)
    • giant granules are found in a small percentage of cells, usually only 1 or 2 within a cell   (MGI Ref ID J:5078)
  • abnormal neutrophil morphology
    • all mice display giant granules in neutrophils from peripheral blood and bone marrow; not observed in control mice   (MGI Ref ID J:5078)
    • giant granules are found in a small percentage of cells, usually only 1 or 2 within a cell   (MGI Ref ID J:5078)
  • defective cytotoxic T cell cytolysis
    • generation of cytotoxic T lymphocytes (CTLs) in response to alloimmune challenge in vivo or in vitro is impaired   (MGI Ref ID J:6692)
  • impaired natural killer cell mediated cytotoxicity
    • spleen cells fail to lyse a variety of natural killer cell sensitive targets, indicating impaired NK cytolysis   (MGI Ref ID J:6213)
    • natural killer cell lysis activity toward tumor cells is impaired   (MGI Ref ID J:6302)
  • immune system phenotype
  • abnormal eosinophil morphology
    • all mice display giant granules in eosinophils from peripheral blood and bone marrow; not observed in control mice   (MGI Ref ID J:5078)
    • giant granules are found in a small percentage of cells, usually only 1 or 2 within a cell   (MGI Ref ID J:5078)
    • giant granules are highly irregular and contain excessive numbers of clumped "crystalloids"   (MGI Ref ID J:5078)
  • abnormal lymphocyte morphology
    • all mice display giant granules in lymphocytes from peripheral blood and bone marrow, with an inner round density; not observed in control mice   (MGI Ref ID J:5078)
    • giant granules are found in a small percentage of cells, usually only 1 or 2 within a cell   (MGI Ref ID J:5078)
  • abnormal neutrophil morphology
    • all mice display giant granules in neutrophils from peripheral blood and bone marrow; not observed in control mice   (MGI Ref ID J:5078)
    • giant granules are found in a small percentage of cells, usually only 1 or 2 within a cell   (MGI Ref ID J:5078)
  • alveolitis
    • inflammation with infiltration of lymphocytes and macrophages in aged mice   (MGI Ref ID J:110157)
  • defective cytotoxic T cell cytolysis
    • generation of cytotoxic T lymphocytes (CTLs) in response to alloimmune challenge in vivo or in vitro is impaired   (MGI Ref ID J:6692)
  • impaired natural killer cell mediated cytotoxicity
    • spleen cells fail to lyse a variety of natural killer cell sensitive targets, indicating impaired NK cytolysis   (MGI Ref ID J:6213)
    • natural killer cell lysis activity toward tumor cells is impaired   (MGI Ref ID J:6302)
  • renal/urinary system phenotype
  • abnormal urine enzyme level
    • lower levels of urinary lysosomal enzymes   (MGI Ref ID J:5590)
  • accumulation of giant lysosomes in kidney/renal tubule cells
    • androgen-stimulated mutants exhibit an accumulation of giant glucuronidase-containing lysosomes in tubule cells near the croticomedullary boundary of the kidney   (MGI Ref ID J:5590)
  • increased kidney weight
    • total weight of kidney is higher in mutants than in wild-type mice after androgen treatment   (MGI Ref ID J:5590)
  • nervous system phenotype
  • abnormal hippocampal mossy fiber morphology
    • infrapyramidal mossy fiber layers within area CA3 of the hippocampus appear to consist of discontinuous clumpings of diffusely scattered small bundles   (MGI Ref ID J:4978)
    • infrapyramidal mossy fiber bundles originate from unrelated areas of the dentate gyrus instead of within the suprapyramidal mossy fiber layers as in controls   (MGI Ref ID J:4978)
  • abnormal hippocampus pyramidal cell layer
    • the pyramidal cell layer is distorted within the CA3 area and appears as cell free-spaces within the cell layer or as few pyramidal cells ectopically scattered in the stratum orients   (MGI Ref ID J:4978)
    • ectopic hippocampus pyramidal cells
      • a few pyramidal cells are ectopically scattered in the stratum orients   (MGI Ref ID J:4978)
  • ectopic Bergmann glia cells
    • arrangement of the Bergmann cells is more dispersed than in controls and a few ectopic Bergmann cells are located in the upper portion of the molecular layer   (MGI Ref ID J:4978)
  • ectopic Purkinje cell
    • ectopic Purkinje cells, mostly found in the lower half of the molecular layer as single cells   (MGI Ref ID J:4978)
  • ectopic cerebellar granule cells
    • clusters of ectopic granule cells in the molecular layer   (MGI Ref ID J:4978)
  • behavior/neurological phenotype
  • abnormal vestibuloocular reflex
    • mice exhibit an inverted optokinetic nystagmus in response to stimulation of only the temporal retina   (MGI Ref ID J:29747)
    • mice exhibit eye movements with a vertical component in response to horizontally moving, full-field stimuli   (MGI Ref ID J:29747)
  • enhanced behavioral response to xenobiotic
    • mutants exhibit increased sleeping time and prolonged bleeding times after treatment with pentobarbital, tribromoethanol, or the steroid anesthetic alphaxalone   (MGI Ref ID J:29294)
  • hearing/vestibular/ear phenotype
  • abnormal vestibuloocular reflex
    • mice exhibit an inverted optokinetic nystagmus in response to stimulation of only the temporal retina   (MGI Ref ID J:29747)
    • mice exhibit eye movements with a vertical component in response to horizontally moving, full-field stimuli   (MGI Ref ID J:29747)
  • homeostasis/metabolism phenotype
  • abnormal urine enzyme level
    • lower levels of urinary lysosomal enzymes   (MGI Ref ID J:5590)
  • integument phenotype
  • abnormal hair shaft melanin granule shape
    • all mice display giant and irregular melanin granules in the medulla and cortex of hairs; not observed in control mice   (MGI Ref ID J:5078)
  • respiratory system phenotype
  • abnormal type II pneumocyte morphology
    • progressive cytoplasmic foamy changes in type II pneumocytes from P0 to 24 months of age, increasing in terms of both the affected cell number and degree of severity as mice age   (MGI Ref ID J:110157)
    • marked swelling and degenerative changes of type II pneumocytes (referred to as "giant lamellar body degeneration" or GLBD) in aged mice   (MGI Ref ID J:110157)
    • enlarged alveolar lamellar bodies
      • most lamellar bodies are increased in size at P0   (MGI Ref ID J:110157)
      • numerous giant-sized lamellar bodies are often fused with each other in aged mice, often resulting in cellular distension and degeneration   (MGI Ref ID J:110157)
  • alveolitis
    • inflammation with infiltration of lymphocytes and macrophages in aged mice   (MGI Ref ID J:110157)
  • atelectasis
    • patchy areas of alveolar collapse associated with marked GLBD, lymphocytic infiltration and slight fibrosis in aged mice   (MGI Ref ID J:110157)
  • overexpanded pulmonary alveoli
    • enlarged air spaces in aged mice   (MGI Ref ID J:110157)
  • pulmonary fibrosis
    • slight fibrosis in aged mice with prominent GLBD   (MGI Ref ID J:110157)
    • no evidence of interstitial change in younger mice with only GLBD   (MGI Ref ID J:110157)

Lystbg/Lystbg

        B6.C3Rl-Lystbg/J
  • cellular phenotype
  • abnormal lysosome morphology
    • light and electron microscopic cytochemistry of cultured fibroblasts shows large dense bodies have an origin through fusion of lysosomes   (MGI Ref ID J:6629)
  • abnormal lysosome physiology
    • significant increase in lysosomal enzyme activity of beta-galactosidase and beta-glucuronidase, and to a lesser extent N-acetyl-beta-hexoseaminidase, in kidney extracts   (MGI Ref ID J:6801)
  • immune system phenotype
  • abnormal NK cell physiology
    • lower natural killer cell activity   (MGI Ref ID J:6801)
  • increased susceptibility to parasitic infection
    • mutants fail to eliminate amastigotes of Leishmania donovani, the parasite causing leishmaniasis, from their spleens over 56 days   (MGI Ref ID J:6946)
    • however, similar levels of anti-leishmanial antibody are produced by mutants as in controls and mutants exhibit a normal response to Leishmania tropica infection   (MGI Ref ID J:6946)
  • respiratory system phenotype
  • abnormal lung development   (MGI Ref ID J:149429)
    • impaired lung alveolus development
      • alveolar maturation is impaired, resulting in abnormally large alveoli   (MGI Ref ID J:149429)
  • emphysema   (MGI Ref ID J:149429)
  • hematopoietic system phenotype
  • abnormal NK cell physiology
    • lower natural killer cell activity   (MGI Ref ID J:6801)

The following phenotype relates to a compound genotype created using this strain.
Contact JAX® Services jaxservices@jax.org for customized breeding options.

A/? Lystbg/Lystbg Tyrp1+/?

        Background Not Specified
  • pigmentation phenotype
  • abnormal eye pigmentation
    • on an agouti black (A-B-) background, the eye pigmentation of mice is only slight at birth but varies from ruby to almost black in adults   (MGI Ref ID J:29744)
  • decreased ear pigmentation
    • on an agouti black (A-B-) background, mice exhibit reduced ear pigmentation relative to wild-type controls   (MGI Ref ID J:29744)
  • decreased tail pigmentation
    • on an agouti black (A-B-) background, mice exhibit reduced tail pigmentation relative to wild-type controls   (MGI Ref ID J:29744)
  • diluted coat color
    • on an agouti black (A-B-) background, mice exhibit a lighter coat color than wild-type controls, particularly at the base of the hairs   (MGI Ref ID J:29744)
    • basal dilution is first noted at ~15 days of age, is somewhat variable, and tends to become darker in older mice   (MGI Ref ID J:29744)
  • irregular coat pigmentation
    • on an agouti black (A-B-) background, mutant dorsal hairs have a yellow subterminal band, a dark grey middle portion, and usually a very light grey base   (MGI Ref ID J:29744)
    • basal dilution is first noted at ~15 days of age, is somewhat variable, and tends to become darker in older mice   (MGI Ref ID J:29744)
  • vision/eye phenotype
  • abnormal eye pigmentation
    • on an agouti black (A-B-) background, the eye pigmentation of mice is only slight at birth but varies from ruby to almost black in adults   (MGI Ref ID J:29744)
  • limbs/digits/tail phenotype
  • decreased tail pigmentation
    • on an agouti black (A-B-) background, mice exhibit reduced tail pigmentation relative to wild-type controls   (MGI Ref ID J:29744)
  • craniofacial phenotype
  • decreased ear pigmentation
    • on an agouti black (A-B-) background, mice exhibit reduced ear pigmentation relative to wild-type controls   (MGI Ref ID J:29744)
  • hearing/vestibular/ear phenotype
  • decreased ear pigmentation
    • on an agouti black (A-B-) background, mice exhibit reduced ear pigmentation relative to wild-type controls   (MGI Ref ID J:29744)
  • integument phenotype
  • decreased ear pigmentation
    • on an agouti black (A-B-) background, mice exhibit reduced ear pigmentation relative to wild-type controls   (MGI Ref ID J:29744)
  • decreased tail pigmentation
    • on an agouti black (A-B-) background, mice exhibit reduced tail pigmentation relative to wild-type controls   (MGI Ref ID J:29744)
  • diluted coat color
    • on an agouti black (A-B-) background, mice exhibit a lighter coat color than wild-type controls, particularly at the base of the hairs   (MGI Ref ID J:29744)
    • basal dilution is first noted at ~15 days of age, is somewhat variable, and tends to become darker in older mice   (MGI Ref ID J:29744)
  • irregular coat pigmentation
    • on an agouti black (A-B-) background, mutant dorsal hairs have a yellow subterminal band, a dark grey middle portion, and usually a very light grey base   (MGI Ref ID J:29744)
    • basal dilution is first noted at ~15 days of age, is somewhat variable, and tends to become darker in older mice   (MGI Ref ID J:29744)
  • growth/size/body phenotype
  • decreased ear pigmentation
    • on an agouti black (A-B-) background, mice exhibit reduced ear pigmentation relative to wild-type controls   (MGI Ref ID J:29744)

A/? Lystbg/Lystbg Tyrp1b/Tyrp1b

        Background Not Specified
  • pigmentation phenotype
  • decreased eye pigmentation
    • on an agouti brown (A-bb) background, newborn beige mice exhibit lighter eyes than on an agouti black (A-B-) background on an agouti brown (A-bb) background, newborn beige mice exhibit lighter eyes than on an agouti black (A-B-) background   (MGI Ref ID J:29744)
  • diluted coat color
    • on an agouti brown (A-bb) background, beige mice exhibit an overall cafe-au-lait coat color   (MGI Ref ID J:29744)
    • the relatively greater dilution effect noted on basal hair is not as pronounced in brown beige as in black beige mice however, the relatively greater dilution effect noted on basal hair is not as pronounced in brown beige as in black beige mice   (MGI Ref ID J:29744)
  • vision/eye phenotype
  • decreased eye pigmentation
    • on an agouti brown (A-bb) background, newborn beige mice exhibit lighter eyes than on an agouti black (A-B-) background on an agouti brown (A-bb) background, newborn beige mice exhibit lighter eyes than on an agouti black (A-B-) background   (MGI Ref ID J:29744)
  • integument phenotype
  • diluted coat color
    • on an agouti brown (A-bb) background, beige mice exhibit an overall cafe-au-lait coat color   (MGI Ref ID J:29744)
    • the relatively greater dilution effect noted on basal hair is not as pronounced in brown beige as in black beige mice however, the relatively greater dilution effect noted on basal hair is not as pronounced in brown beige as in black beige mice   (MGI Ref ID J:29744)

a/a Lystbg/Lystbg

        involves: C3H/Rl * C57BL/6J
  • pigmentation phenotype
  • abnormal choroid melanin granule morphology
    • 80% of premelanosomes in the choroid and retina are fused to form giant granules   (MGI Ref ID J:5346)
  • abnormal retinal melanin granule morphology
    • 80% of premelanosomes in the retina and choroid are fused to form giant granules   (MGI Ref ID J:5346)
  • vision/eye phenotype
  • abnormal choroid melanin granule morphology
    • 80% of premelanosomes in the choroid and retina are fused to form giant granules   (MGI Ref ID J:5346)
  • abnormal retinal melanin granule morphology
    • 80% of premelanosomes in the retina and choroid are fused to form giant granules   (MGI Ref ID J:5346)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Lystbg related

Cardiovascular Research
Atherosclerosis

Dermatology Research
Color and White Spotting Defects

Hematological Research
Immunological Defects
Platelet Defects
      platelet storage pool deficiency

Immunology, Inflammation and Autoimmunity Research
CD Antigens, Antigen Receptors, and Histocompatibility Markers
Immunodeficiency
Intracellular Signaling Molecules

Internal/Organ Research
Kidney Defects
      lysosomal enzyme abnormalities

Metabolism Research

Research Tools
Immunology, Inflammation and Autoimmunity Research
      NK Cell Deficiency

Tyr+ related

Dermatology Research
Color and White Spotting Defects
      oculocutaneous albinism, type I

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Lystbg
Allele Name beige
Allele Type Radiation induced
Common Name(s) 30B/22B; CHS mice; bg;
Strain of OriginC3H/Rl
Gene Symbol and Name Lyst, lysosomal trafficking regulator
Chromosome 13
Gene Common Name(s) Beige; CHS; CHS1; D13Sfk13; DNA segment, Chr 13, Stephen F. Kingsmore 13; beige; bg;
Molecular Note This allele is an insertion of a partial LINE 1 repetitive element into an intron of the gene. The insertion included only the most 3' 1097 bp of the element producing a frameshift mutation resulting in a truncated protein predicted to be missing the last 1442 amino acids. [MGI Ref ID J:33734] [MGI Ref ID J:41243]
 
Allele Symbol Oca2+
Allele Name wild type
Allele Type Not Applicable
Gene Symbol and Name Oca2, oculocutaneous albinism II
Chromosome 7
Gene Common Name(s) BEY; BEY1; BEY2; BOCA; D15S12; D7H15S12; D7Icr28RN; D7Nic1; DNA segment, Chr 7, Institute for Cancer Research 28RN; DNA segment, Chr 7, Nicholls 1; DNA segment, Chr 7, human D15S12; EYCL; EYCL2; EYCL3; HCL3; P; PED; SHEP1; p; pink-eyed dilution;
 
Allele Symbol Tyr+
Allele Name wild type
Allele Type Not Applicable
Gene Symbol and Name Tyr, tyrosinase
Chromosome 7
Gene Common Name(s) ATN; CMM8; OCA1; OCA1A; OCAIA; SHEP3; albino; c; skc35; skin/coat color 35;

Genotyping

Genotyping Information


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Additional References

Gallin JI; Bujak JS; Patten E; Wolff SM. 1974. Granulocyte function in the Chediak-Higashi syndrome of mice. Blood 43(2):201-6. [PubMed: 4589319]  [MGI Ref ID J:5405]

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Tiberghien F; Ceredig R; Loor F. 1994. Influence of the lpr environment on the lymph node cell phenotypes in C57BL/6 nubg and nulpr chimeras. Immunology 83(4):552-61. [PubMed: 7875735]  [MGI Ref ID J:21826]

Tischfield JA; Ruddle FH. 1974. Assignment of the gene for adenine phosphoribosyltransferase to human chromosome 16 by mouse-human somatic cell hybridization. Proc Natl Acad Sci U S A 71(1):45-9. [PubMed: 4129802]  [MGI Ref ID J:5409]

Verzi MP; Khan AH; Ito S; Shivdasani RA. 2008. Transcription factor foxq1 controls mucin gene expression and granule content in mouse stomach surface mucous cells. Gastroenterology 135(2):591-600. [PubMed: 18558092]  [MGI Ref ID J:141778]

Waggie KS; Wu-Owens J; Hollifield V; Hansen CT. 1992. Lymphoblastic lymphoma in a colony of N:NIH(S)-bg-nu-xid mice. Lab Anim Sci 42(4):375-7. [PubMed: 1434498]  [MGI Ref ID J:2184]

Wang Q; Huang C; Zeng F; Xue M; Zhang X. 2010. Activation of the Hh pathway in periosteum-derived mesenchymal stem cells induces bone formation in vivo: implication for postnatal bone repair. Am J Pathol 177(6):3100-11. [PubMed: 20971735]  [MGI Ref ID J:167645]

Warner T; Balish E. 1995. Pulmonary alveolar proteinosis. A spontaneous and inducible disease in immunodeficient germ-free mice. Am J Pathol 146(4):1017-24. [PubMed: 7717446]  [MGI Ref ID J:24415]

Whitney PL; Starcher B; Brittain C. 1992. Soluble beta-galactoside specific lectin is developmentally regulated in lungs of neonatal black mice and beige mice. Exp Lung Res 18(4):553-61. [PubMed: 1516572]  [MGI Ref ID J:2387]

Willingham MC; Spicer SS; Vincent RA Jr. 1981. The origin and fate of large dense bodies in beige mouse fibroblasts. Lysosomal fusion and exocytosis. Exp Cell Res 136(1):157-68. [PubMed: 6170520]  [MGI Ref ID J:6629]

Winslow GM; Yager E; Shilo K; Collins DN; Chu FK. 1998. Infection of the laboratory mouse with the intracellular pathogen Ehrlichia chaffeensis. Infect Immun 66(8):3892-9. [PubMed: 9673277]  [MGI Ref ID J:48876]

Yang PL; Althage A; Chung J; Maier H; Wieland S; Isogawa M; Chisari FV. 2010. Immune effectors required for hepatitis B virus clearance. Proc Natl Acad Sci U S A 107(2):798-802. [PubMed: 20080755]  [MGI Ref ID J:156523]

Yoshizawa M; Okada T; Morikawa Y; Sasaki F; Kiso Y. 1994. Murine granulated metrial gland cell population in beige (bg/bg) and SCID (scid/scid) genotypes. J Vet Med Sci 56(2):415-6. [PubMed: 8075241]  [MGI Ref ID J:21177]

Zhang C; Cui Y; Houston S; Chang LJ. 1996. Protective immunity to HIV-1 in SCID/beige mice reconstituted with peripheral blood lymphocytes of exposed but uninfected individuals. Proc Natl Acad Sci U S A 93(25):14720-5. [PubMed: 8962121]  [MGI Ref ID J:37253]

de Oliveira VL; Keijsers RR; van de Kerkhof PC; Seyger MM; Fasse E; Svensson L; Latta M; Norsgaard H; Labuda T; Hupkens P; van Erp PE; Joosten I; Koenen HJ. 2012. Humanized mouse model of skin inflammation is characterized by disturbed keratinocyte differentiation and influx of IL-17A producing T cells. PLoS One 7(10):e45509. [PubMed: 23094018]  [MGI Ref ID J:192181]

de Saint Basile G; Fischer A; Dautzenberg MD; Durandy A; Le Deist F; Angles-Cano E; Griscelli C. 1985. Enhanced plasminogen-activator production by leukocytes in the human and murine Chediak-Higashi syndrome. Blood 65(5):1275-81. [PubMed: 4039611]  [MGI Ref ID J:7851]

Oca2+ related

Haldane JBS; Sprunt AD; Haldane NM. 1915. Reduplication in mice J Genet 5:133-135.  [MGI Ref ID J:100]

The RIKEN BioResource Center. 2006. Information obtained from The RIKEN BioResource Center Unpublished :.  [MGI Ref ID J:104881]

Tyr+ related

Erickson RP; Gluecksohn-Waelsch S; Cori CF. 1968. Glucose-6-phosphatase deficiency caused by radiation-induced alleles at the albino locus in the mouse. Proc Natl Acad Sci U S A 59(2):437-44. [PubMed: 4296364]  [MGI Ref ID J:5063]

Lossie AC; Nakamura H; Thomas SE; Justice MJ. 2005. Mutation of l7Rn3 shows that Odz4 is required for mouse gastrulation. Genetics 169(1):285-99. [PubMed: 15489520]  [MGI Ref ID J:96673]

Miller DA; Dev VG; Tantravahi R; Miller OJ; Schiffman MB; Yates RA; Gluecksohn-Waelsch S. 1974. Cytological detection of the c-25H deletion involving the albino (c) locus on chromosome 7 in the mouse. Genetics 78(3):905-10. [PubMed: 4141683]  [MGI Ref ID J:5520]

Oak Ridge National Laboratory. 2005. Information obtained from the Oak Ridge National Laboratory Mutant Mouse Database (ORNL), Oak Ridge, TN Unpublished :.  [MGI Ref ID J:100221]

Sweet HO. 1987. Acromelanic (c<a>) Mouse News Lett 78:56.  [MGI Ref ID J:14994]

Taibi AV; Lighthouse JK; Grady RC; Shroyer KR; Holdener BC. 2013. Development of a conditional Mesd (mesoderm development) allele for functional analysis of the low-density lipoprotein receptor-related family in defined tissues. PLoS One 8(10):e75782. [PubMed: 24124512]  [MGI Ref ID J:209024]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Colony Maintenance

Diet Information LabDiet® 5K52/5K67

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $3300.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We willfulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $4290.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We willfulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Control Information

  Control
   000686 SJL/J
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

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Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.


See Terms of Use tab for General Terms and Conditions


The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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JAX® Mice
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phone:207-288-6470

JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


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