JAX Mice Database - 000501 B6CBACa A<w-J>/A-Aifm1<Hq>/J

Strain Name:	B6CBACa A^w-J/A-Aifm1^Hq/J
Stock Number:	000501
Availability:	Repository- Live

Description
Phenotype
Genes & alleles
Genotyping
Health & husbandry
References
Purchasing information
Terms of Use

Description

Strain Information

Former Names B6CBACa A^w-J/A-Pdcd8^Hq/J (Changed: 20-NOV-06 )

B6CBACa-A^w-J/A-Hq (Changed: 15-DEC-04 )

B6CBACa-A^w-J/A-Pdcd8^Hq (Changed: 15-DEC-04 )

Type Mutant Strain; Spontaneous Mutation;
Additional information on Genetically Engineered Mutant Mice.

Species laboratory mouse

Generation (N15F1p)+N15 (21-JAN-08)

Appearance
white bellied agouti or agouti, balding, small, ataxic
Related Genotype: A^w-J/? or A/A, Aifm1^Hq/Y male or Aifm1^Hq/Aifm1^Hq female

white bellied agouti or agouti, possible patchy fur
Related Genotype: A^w-J/? or A/A, Aifm1^Hq/+ female
Description
Harlequin mice exhibit paucity of fur resulting in near baldness in hemizygous males and homozygous females. Heterozygous females have a patchy absence of hair that is not always obvious, since the degree of hair loss is notably less than 50%. Homozygotes and hemizygous males weigh less than heterozygous or wild type controls. Ataxia is noticeable by 5 months and progresses as the mice age. Initially the ataxia manifests itself as a side-to-side, unsteady gait with a lateral tremor visible at rest. A delayed cerebellar cortical atrophy has been characterized in these mutants, with an apoptotic loss of granule cells beginning at 4 months of age and a necrotic loss of Purkinje cells occurring subsequently. The granule cells re-enter the cell cycle, but the Purkinje cells do not, supporting the postulate that inappropriate cell cycle re-entry of terminally differentiated neurons can induce apoptosis. Cell loss is greater in the caudal lobules of the cerebellum and is extensive by 9 to 11 months of age. Retinal degeneration is found beginning with ganglion and amacrine cell loss in the ganglion cell layer at 3 months of age, and progresses with cell loss in the inner and outer nuclear layers and reduction of rod and cone ERG responses at 4 months of age. By 10 months, the rod and cone ERG responses are gone, and at 11 months of age there isapparent cell loss in all layers of the retina. No cerebellar or retinal abnormalities were found in heterozygous females. Catalase activity and expression and total glutathione levels are increased in the cerebella of mutant mice, but not in other brain regions, and lipid hydroperoxidases are increased in brain and heart tissue. Primary granule cell cultures, but not cortical cultures, from harlequin mice show increased sensitivity to peroxide. Hemizygous males, homozygous females and hemizygous females are all viable and fertile. (Barber 1971; Falconer and Isaacson 1972; Bronson et al., 1990; Klein et al., 2002.)

Control Information

	Control
	Wild-type from the colony

Considerations for Choosing Controls

Related Strains

Strains carrying A^w-J allele

000202 AEJ/Gn-bd/J

000199 AEJ/GnLeJ

000593 B6 x B6CBCa A^w-J/A-Grid2^Lc T(2;6)7Ca Mitf^Mi-wh/J

000502 B6 x B6CBCa A^w-J/A-Myo5a^flr Gnb5^flr/J

000599 B6 x B6CBCa A^w-J/A-T(5;13)264Ca Kit^W-v/J

002016 B6(Cg)-A^w-J Eda^Ta-6J Chr Y^B6-Sxr/EiJ

000552 B6-A^w-J-Eda^Ta-6J.Cg-Sxr

001730 B6-A^w-J-Eda^Ta-6J.Cg-Sxr^b Hya^-/J

000841 B6-A^w-J.CBy-Eda^Ta-By/J

001809 B6-A^w-J.Cg-Eda^Ta-6J +/+ Ar^Tfm/J

000600 B6-Gpi1^b x B6CBCa A^w-J/A-T(7;15)9H Gpi1^a/J

100409 B6129PF1/J-A^w-J/A^w

004200 B6;CBACa A^w-J/A-Npr2^cn-2J/J

000505 B6C3 A^w-J/A-Muted^mu/J

000314 B6CBACa A^w-J/A-Eda^Ta/J-XO

001046 B6CBACa A^w-J/A-Grid2^Lc/J

000500 B6CBACa A^w-J/A-Gs/J

002703 B6CBACa A^w-J/A-Hydin^hy3/J

000247 B6CBACa A^w-J/A-Kcnj6^wv/J

000287 B6CBACa A^w-J/A-Plp1^jp Eda^Ta/J

000515 B6CBACa A^w-J/A-Sfn^Er/J

000242 B6CBACa A^w-J/A-spc/J

000288 B6CBACa A^w-J/A-we a Mafb^kr/J

001201 B6CBACaF1/J-A^w-J/A

001752 B6CBCa A^w-J/A-T(7;15)9H/J

000200 C3FeB6 A/A^w-J-Ank^ank/J

000638 C3FeB6 A/A^w-J-Spnb4^qv-J/J

001203 C3FeB6F1/J A/A^w-J

000338 C57BL/6J A^w-J-Eda^Ta-6J/J

000569 C57BL/6J-A^w-J-Eda^Ta +/+ Ar^Tfm/J

000051 C57BL/6J-A^w-J/J

View Strains carrying A^w-J (31 strains)

Strains carrying other alleles of a

003301 (C57BL/6J x C3H-Eya1^bor)F1/J

000251 AEJ.Cg-a^e +/a Gdf5^bp-H/J

000202 AEJ/Gn-bd/J

000199 AEJ/GnLeJ

000427 B10.CE-H13^b A^w/(30NX)SnJ

000420 B10.LP-H13^b A^w/Sn

000477 B10.PA-Pldn^pa H3^e a^t/SnJ

000419 B10.UW-H3^b we Pax1^un a^t/SnJ

003879 B10;TFLe-a/a T tf/+ tf/J

001538 B6 x B6C3Sn a/A-T(1;9)27H/J

000916 B6 x B6C3Sn a/A-T(5;12)31H/J

000602 B6 x B6C3Sn a/A-T(8;16)17H/J

002083 B6 x B6EiC3 a/A-T(7;16)235Dn/J

000507 B6 x B6EiC3 a/A-Otc^spf/J

000618 B6 x FSB/GnEi a/a Ctsl^fs/J

000577 B6 x STOCK a Oca2^p Hps5^ru2 Ednrb^s/J

000601 B6 x STOCK a/a T(7;18)50H/J

000592 B6 x STOCK T(2;4)13H a/J

000769 B6.C/(HZ18)By-a^t-44J/J

000001 B6.C3 A/a Mgrn1^md/J

000203 B6.C3-A^iy/a/J

001572 B6.C3-a^m-J/J

000017 B6.C3Fe-A^vy/J

000628 B6.CE-A Amy1^b Amy2^b/J

005505 B6.Cg-A^y Slc7a11^sut/LmLlp

000021 B6.Cg-A^y/J

004200 B6;CBACa A^w-J/A-Npr2^cn-2J/J

000785 B6;D2-a Es1^e/J

000604 B6C3 a/A-T(10;13)199H +/+ Lyst^bg-J/J or Lyst^bg-2J/J

002807 B6C3Fe a/a-Meox2^fla/J

000224 B6C3Fe a/a-Scyl1^mdf/J

001037 B6C3Fe a/a-Agtpbp1^pcd/J

000221 B6C3Fe a/a-Alx4^lst-J/J

002062 B6C3Fe a/a-Atp7a^Mo-8J/J

001756 B6C3Fe a/a-Cacng2^stg/J

001815 B6C3Fe a/a-Col1a2^oim/J

000231 B6C3Fe a/a-Csf1^op/J

000209 B6C3Fe a/a-Dh/J

000211 B6C3Fe a/a-Dst^dt-J/J

000210 B6C3Fe a/a-Edar^dl-J/J

000207 B6C3Fe a/a-Edaradd^cr/J

000182 B6C3Fe a/a-Eef1a2^wst/J

001278 B6C3Fe a/a-Glra1^spd/J

000241 B6C3Fe a/a-Glrb^spa/J

002875 B6C3Fe a/a-Hoxd13^spdh/J

000304 B6C3Fe a/a-Krt71^Ca Scn8a^med-J/J

000226 B6C3Fe a/a-Large^myd/J

000636 B6C3Fe a/a-Lmx1a^dr-J/J

001280 B6C3Fe a/a-Lse/J

001573 B6C3Fe a/a-Mitf^Mi/J

001035 B6C3Fe a/a-Napa^hyh/J

000181 B6C3Fe a/a-Otog^twt/J

000278 B6C3Fe a/a-Papss2^bm Hps1^ep Hps6^ru/J

000205 B6C3Fe a/a-Papss2^bm/J

002078 B6C3Fe a/a-Pcdh15^av-2J/J

000246 B6C3Fe a/a-Pitpna^vb/J

001430 B6C3Fe a/a-Ptch1^mes/J

000506 B6C3Fe a/a-Qk^qk/J

000235 B6C3Fe a/a-Reln^rl/J

000237 B6C3Fe a/a-Rora^sg/J

000290 B6C3Fe a/a-Sox10^Dom/J

000230 B6C3Fe a/a-Tcirg1^oc/J

003612 B6C3Fe a/a-Trak1^hyrt/J

001512 B6C3Fe a/a-Ttn^mdm/J

001607 B6C3Fe a/a-Unc5c^rcm/J

000005 B6C3Fe a/a-Wc/J

000243 B6C3Fe a/a-Wnt1^sw/J

000248 B6C3Fe a/a-Xpl/J

001750 B6C3Fe a/a-Xs^J/J

000624 B6C3Fe a/a-anx/J

003020 B6C3Fe a/a-dep/J

002018 B6C3Fe a/a-din/J

002339 B6C3Fe a/a-nma/J

000240 B6C3Fe a/a-soc/J

000063 B6C3Fe a/a-sy/J

001055 B6C3Fe a/a-tip/J

000245 B6C3Fe a/a-tn/J

000065 B6C3Fe a/a-we Pax1^un a^t/J

000296 B6C3Fe-a/a Hoxa13^Hd Mcoln3^Va-J/J

000019 B6C3Fe-a/a-Itpr1^opt/J

001022 B6C3FeF1/J a/a

001752 B6CBCa A^w-J/A-T(7;15)9H/J

000971 B6EiC3 a/A-Och/J

000551 B6EiC3 a/A-Tbx15^de-H/J

006450 B6EiC3 a/A-Vss/J

000557 B6EiC3-+ a/Lnp^Ul A/J

000504 B6EiC3Sn a/A-Cacnb4^lh/J

000553 B6EiC3Sn a/A-Egfr^wa2 Wnt3a^vt/J

000503 B6EiC3Sn a/A-Gy/J

001811 B6EiC3Sn a/A-Otc^spf-ash/J

002343 B6EiC3Sn a/A-Otc^spf/J

000391 B6EiC3Sn a/A-Pax6^Sey-Dey/J

001924 B6EiC3Sn a/A-Ts(17¹⁶)65Dn

001923 B6EiC3Sn a/A-Ts(4¹⁷)2Lws Tim/J

000200 C3FeB6 A/A^w-J-Ank^ank/J

000638 C3FeB6 A/A^w-J-Spnb4^qv-J/J

000225 C3FeLe.B6 a/a-Ptpn6^me/J

008425 C3FeLe.B6-a Trl/J

000198 C3FeLe.B6-a/J

000291 C3FeLe.Cg-a/a Hm Kitl^Sl Krt71^Ca-J/J

001272 C3H/HeSnJ-A^hvy/J

000099 C3HeB/FeJ-A^vy/J

001886 C3HeB/FeJLe a/a-gnd/J

000584 C57BL/6J-+ T(1;2)5Ca/a +/J

000258 C57BL/6J-Aⁱ/a/J

000774 C57BL/6J-A^sy/a/J

000055 C57BL/6J-a^t-33J/J

000070 C57BL/6J-a^td/J

000284 CWD/LeJ

000670 DBA/1J

000671 DBA/2J

001057 HPT/LeJ

000260 JGBF/LeJ

002468 KK.Cg-A^y/J

000262 LS/LeJ

000283 LT.CAST-A/J

000265 MY/HuLeJ

000308 SSL/LeJ

001759 STOCK A Tyr^c Sha/J

001427 STOCK A^w us/J

000994 STOCK a Myo5a^d Mreg^dsu/J

000064 STOCK a Tyrp1^b Si^si/J

002238 STOCK a Tyrp1^b shmy/J

001433 STOCK a skt/J

000579 STOCK a tp/J

000319 STOCK a us/J

002648 STOCK a/a Cln6^nclf/J

000317 STOCK a/a Egfr^wa2/J

000302 STOCK a/a Mitf^Mi-wh +/+ Itpr1^opt/J

000286 STOCK a/a Myo5a^d fd/+ +/J

000206 STOCK a/a Tyr^c-h/J

001432 STOCK a/a Tyrp1^b sks/Tyrp1^b +/J

000281 STOCK a/a ma ft/ma ft/J

000312 STOCK stb + a/+ Fign^fi a/J

000596 STOCK T(2;11)30H/+ x AEJ-a Gdf5^bp-H/J or A/J-a Gdf5^bp-J/J

000970 STOCK T(2;16)28H A/T(2;16)28H a/J

000590 STOCK T(2;4)1Sn a/J

000594 STOCK T(2;8)26H a/T(2;8)26H a Tyrp1⁺/Tyrp1^b/J

000623 TR/DiEiJ

View Strains carrying other alleles of a (139 strains)

Additional Web Information

Genetic Quality Control Annual Report
JAX^® NOTES, Winter 2002; 488. Jackson Laboratory Scientist Identifies Gene Implicated in Oxidative Stress and Neurodegeneration.

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms
assigned by genotype

Aifm1^Hq/Aifm1⁺
B6CBACa-A^w-J/A
skin/coat/nails phenotype

partial hair loss (MGI Ref ID J:79052)

patchy irregular hair loss

behavior/neurological phenotype

*normal* behavior/neurological phenotype (MGI Ref ID J:79052)

heterozygotes are normal with respect to ataxia

nervous system phenotype

*normal* nervous system phenotype (MGI Ref ID J:79052)

no loss of granule cells seen to 26 months of age

Aifm1^Hq/Aifm1^Hq
B6CBACa-A^w-J/A
skin/coat/nails phenotype

partial hair loss (MGI Ref ID J:79052)

described as nearly bald

behavior/neurological phenotype

abnormal motor capabilities/coordination/movement (MGI Ref ID J:79052)

abnormal gait (MGI Ref ID J:79052)

side by side unsteady gait at 5 months of age

marked lateral swaying when moving and at rest by 9 months of age

ataxia (MGI Ref ID J:79052)

age of onset is approximately 5 months of age

mild

truncal ataxia by 9 months

tremors (MGI Ref ID J:79052)

age of onset is approximately 5 months

a perceptible lateral tremor at rest by 9 months of age

pharmacologically induced seizures (MGI Ref ID J:98103)

mice are protected against CA3 region damage at both 4 and 7 days after kainic acid induced stage 4 seizures although some cell damage is observed

nervous system phenotype

abnormal cerebellar cortex morphology (MGI Ref ID J:78983)

Purkinje cell degeneration (MGI Ref ID J:79052)

described as mild and patchy in the folia, but extensive in the floccular lobes in mice 5-8 months of age

Purkinje cell loss occurs later than granule cell loss

cell loss apparently due to necrosis

many Purkinje cells are dead by 7 months of age

abnormal cerebellar granule layer (MGI Ref ID J:79052)

no reduction in the folia but extensive loss in the floccular lobes in mice 5-8 months of age

losses are preferentially from the caudal vermis and hemispheres

most caudal granule cells are lost by 12 months

abnormal granule neuron (MGI Ref ID J:78983)

pyknotic granule cell nuclei at 4 months of age

apoptotic granule cells seen at 4 months of age

amacrine cell degeneration (MGI Ref ID J:78983)

cell loss is seen in the ganglion layer after about 3 months of age

decreased susceptibility to neuronal excitotoxicity (MGI Ref ID J:98103)

resistant to cell death induced by glutamate, NMDA, and kainic acid

pharmacologically induced seizures (MGI Ref ID J:98103)

mice are protected against CA3 region damage at both 4 and 7 days after kainic acid induced stage 4 seizures although some cell damage is observed

retinal ganglion cell degeneration (MGI Ref ID J:78983)

ganglion cell loss is seen after about 3 months of age

small cerebellum (MGI Ref ID J:78983)

cerebellum normal before 3 months

much smaller at 7 months

vision/eye phenotype

abnormal eye electrophysiology (MGI Ref ID J:78983)

both rod and cone ERG are diminished by 4 months of age

ERG responses are completely abolished by 10 months of age

amacrine cell degeneration (MGI Ref ID J:78983)

cell loss is seen in the ganglion layer after about 3 months of age

retinal degeneration (MGI Ref ID J:78983)

onset of retinal degeneration is after 3 months of age

cell loss is seen in all layers of the retina by 11 months

retinal ganglion cell degeneration (MGI Ref ID J:78983)

ganglion cell loss is seen after about 3 months of age

thin retinal inner plexiform layer (MGI Ref ID J:78983)

thinning by 11 months

thin retinal outer plexiform layer (MGI Ref ID J:78983)

thinning by 11 months

cellular phenotype

abnormal mitosis (MGI Ref ID J:78983)

cerebellar granule cells and retina cells re-enter the cell cycle with greater frequency than in controls

number of cycling cells in the cerebellum and retina increase through 7 months and then declines

increased cellular sensitivity to hydrogen peroxide (MGI Ref ID J:78983)

granule cells of the cerebellum in culture show increased sensitivity to hydrogen peroxide

oxidative stress (MGI Ref ID J:78983)

increased sensitivity of the cerebellum to oxidative stress

catalase activity increased in the cerebellum at 1 and 3 months of age

oxidative damage to mitochondria of the cerebellar granular layer and the ganglion layer of the retina

slightly increased as a result of transverse aortic banding

life span-post-weaning/aging

abnormal induced morbidity/mortality (MGI Ref ID J:110278)

significantly reduced survival at both 1 and 4 weeks after transverse aortic banding

cardiovascular system phenotype

abnormal cardiovascular system morphology (MGI Ref ID J:110278)

cardiac hypertrophy (MGI Ref ID J:110278)

hypertrophy due to transverse aorting banding is twice as great as is seen in controls

dilated left ventricle (MGI Ref ID J:110278)

increased left ventricular internal diameter relative to controls as a result of transverse aortic banding

increased cardiomyocyte apoptosis (MGI Ref ID J:110278)

greatly increased levels of both apoptosis and necrosis in myocytes after transverse aortic banding

abnormal cardiovascular system physiology (MGI Ref ID J:110278)

abnormal myocardial fiber physiology (MGI Ref ID J:110278)

cardiomyocytes more prone to die in response to exposure to hydrogen peroxide

altered response to myocardial infarction (MGI Ref ID J:110278)

increased sensitivity to ischemia/reperfusion injury

over 80% fail to survive 30minutes of left anterior descending artery occlusion followed by 2 to 24 hours of reperfusion

increased infarction size (MGI Ref ID J:110278)

experimental infarction size is increased by 50% over controls in 2 month old animals and by 78% in 6 month old animals

apoptosis in viable muscle cells is also increased

decreased cardiac muscle contractility (MGI Ref ID J:110278)

deterioration of cardiac contractility as a result of transverse aortic banding

muscle phenotype

decreased cardiac muscle contractility (MGI Ref ID J:110278)

deterioration of cardiac contractility as a result of transverse aortic banding

increased cardiomyocyte apoptosis (MGI Ref ID J:110278)

greatly increased levels of both apoptosis and necrosis in myocytes after transverse aortic banding

homeostasis/metabolism phenotype

altered response to myocardial infarction (MGI Ref ID J:110278)

increased sensitivity to ischemia/reperfusion injury

over 80% fail to survive 30minutes of left anterior descending artery occlusion followed by 2 to 24 hours of reperfusion

increased infarction size (MGI Ref ID J:110278)

experimental infarction size is increased by 50% over controls in 2 month old animals and by 78% in 6 month old animals

apoptosis in viable muscle cells is also increased

decreased susceptibility to neuronal excitotoxicity (MGI Ref ID J:98103)

resistant to cell death induced by glutamate, NMDA, and kainic acid

pharmacologically induced seizures (MGI Ref ID J:98103)

mice are protected against CA3 region damage at both 4 and 7 days after kainic acid induced stage 4 seizures although some cell damage is observed

Aifm1^Hq/Y
B6CBACa-A^w-J/A
skin/coat/nails phenotype

partial hair loss (MGI Ref ID J:79052)

described as nearly bald

behavior/neurological phenotype

abnormal motor capabilities/coordination/movement (MGI Ref ID J:79052)

abnormal gait (MGI Ref ID J:79052)

side by side unsteady gait at 5 months of age

marked lateral swaying when moving and at rest by 9 months of age

ataxia (MGI Ref ID J:79052)

age of onset is approximately 5 months of age

mild

truncal ataxia by 9 months

tremors (MGI Ref ID J:79052)

age of onset is approximately 5 months

a perceptible lateral tremor at rest by 9 months of age

pharmacologically induced seizures (MGI Ref ID J:98103)

mice are protected against CA3 region damage at both 4 and 7 days after kainic acid induced stage 4 seizures although some cell damage is observed

nervous system phenotype

abnormal cerebellar cortex morphology (MGI Ref ID J:78983)

Purkinje cell degeneration (MGI Ref ID J:78983)

Purkinje cell loss occurs later than granule cell loss

cell loss apparently due to necrosis

many Purkinje cells are dead by 7 months of age

described as mild and patchy in the folia, but extensive in the floccular lobes in mice 5-8 months of age

abnormal cerebellar granule layer (MGI Ref ID J:78983)

losses are preferentially from the caudal vermis and hemispheres

most caudal granule cells are lost by 12 months

no reduction in the folia but extensive loss in the floccular lobes in mice 5-8 months of age

abnormal granule neuron (MGI Ref ID J:78983)

pyknotic granule cell nuclei at 4 months of age

apoptotic granule cells seen at 4 months of age

amacrine cell degeneration (MGI Ref ID J:78983)

cell loss is seen in the ganglion layer after 3 months of age

decreased susceptibility to neuronal excitotoxicity (MGI Ref ID J:98103)

resistant to cell death induced by glutamate, NMDA, and kainic acid

pharmacologically induced seizures (MGI Ref ID J:98103)

mice are protected against CA3 region damage at both 4 and 7 days after kainic acid induced stage 4 seizures although some cell damage is observed

retinal ganglion cell degeneration (MGI Ref ID J:78983)

ganglion cell loss is seen after about 3 months of age

small cerebellum (MGI Ref ID J:78983)

much smaller at 7 months

cerebellum normal before 3 months

vision/eye phenotype

abnormal eye electrophysiology (MGI Ref ID J:78983)

both rod and cone ERG are diminished by 4 months of age

ERG responses are completely abolished by 10 months of age

amacrine cell degeneration (MGI Ref ID J:78983)

cell loss is seen in the ganglion layer after 3 months of age

retinal degeneration (MGI Ref ID J:78983)

onset of retinal degeneration is after 3 months of age

cell loss is seen in all layers of the retina by 11 months

retinal ganglion cell degeneration (MGI Ref ID J:78983)

ganglion cell loss is seen after about 3 months of age

thin retinal inner plexiform layer (MGI Ref ID J:78983)

thinning by 11 months

thin retinal outer plexiform layer (MGI Ref ID J:78983)

thinning by 11 months

cellular phenotype

abnormal mitosis (MGI Ref ID J:78983)

cerebellar granule cells and retina cells re-enter the cell cycle with greater frequency than in controls

number of cycling cells in the cerebellum and retina increase through 7 months and then declines

increased cellular sensitivity to hydrogen peroxide (MGI Ref ID J:78983)

granule cells of the cerebellum in culture show increased sensitivity to hydrogen peroxide

oxidative stress (MGI Ref ID J:78983)

increased sensitivity of the cerebellum to oxidative stress

catalase activity increased in the cerebellum at 1 and 3 months of age

oxidative damage to mitochondria of the cerebellar granular layer and the ganglion layer of the retina

slightly increased as a result of transverse aortic banding

life span-post-weaning/aging

abnormal induced morbidity/mortality (MGI Ref ID J:110278)

significantly reduced survival at both 1 and 4 weeks after transverse aortic banding

cardiovascular system phenotype

abnormal cardiovascular system morphology (MGI Ref ID J:110278)

cardiac hypertrophy (MGI Ref ID J:110278)

hypertrophy due to transverse aorting banding is twice as great as is seen in controls

dilated left ventricle (MGI Ref ID J:110278)

increased left ventricular internal diameter relative to controls as a result of transverse aortic banding

increased cardiomyocyte apoptosis (MGI Ref ID J:110278)

greatly increased levels of both apoptosis and necrosis in myocytes after transverse aortic banding

abnormal cardiovascular system physiology (MGI Ref ID J:110278)

abnormal myocardial fiber physiology (MGI Ref ID J:110278)

cardiomyocytes more prone to die in response to exposure to hydrogen peroxide

altered response to myocardial infarction (MGI Ref ID J:110278)

increased sensitivity to ischemia/reperfusion injury

over 80% fail to survive 30minutes of left anterior descending artery occlusion followed by 2 to 24 hours of reperfusion

increased infarction size (MGI Ref ID J:110278)

experimental infarction size is increased by 50% over controls in 2 month old animals and by 78% in 6 month old animals

apoptosis in viable muscle cells is also increased

decreased cardiac muscle contractility (MGI Ref ID J:110278)

deterioration of cardiac contractility as a result of transverse aortic banding

muscle phenotype

decreased cardiac muscle contractility (MGI Ref ID J:110278)

deterioration of cardiac contractility as a result of transverse aortic banding

increased cardiomyocyte apoptosis (MGI Ref ID J:110278)

greatly increased levels of both apoptosis and necrosis in myocytes after transverse aortic banding

homeostasis/metabolism phenotype

altered response to myocardial infarction (MGI Ref ID J:110278)

increased sensitivity to ischemia/reperfusion injury

over 80% fail to survive 30minutes of left anterior descending artery occlusion followed by 2 to 24 hours of reperfusion

increased infarction size (MGI Ref ID J:110278)

experimental infarction size is increased by 50% over controls in 2 month old animals and by 78% in 6 month old animals

apoptosis in viable muscle cells is also increased

decreased susceptibility to neuronal excitotoxicity (MGI Ref ID J:98103)

resistant to cell death induced by glutamate, NMDA, and kainic acid

pharmacologically induced seizures (MGI Ref ID J:98103)

mice are protected against CA3 region damage at both 4 and 7 days after kainic acid induced stage 4 seizures although some cell damage is observed

The following phenotype information may relate to a genetic background differing from this JAX^® Mice strain.
Aifm1^Hq/Aifm1^Hq
involves: CF1
skin/coat/nails phenotype

partial hair loss (MGI Ref ID J:15073)

mice have bald patches of varying extend and distribution

growth/size phenotype

decreased body weight (MGI Ref ID J:15073)

adults are about 1/3 the weight of controls

Aifm1^Hq/Y
involves: CF1
skin/coat/nails phenotype

partial hair loss (MGI Ref ID J:15073)

mice have bald patches of varying extend and distribution

growth/size phenotype

decreased body weight (MGI Ref ID J:15073)

adults are about 1/3 the weight of controls

View Research Applications

Research Applications
This mouse can be used to support research in many areas including:
Aifm1^Hq related

Apoptosis Research
Endogenous Regulators

Cardiovascular Research

Cell Biology Research
Cell Cycle Regulation

Dermatology Research
Skin and Hair Texture Defects

Developmental Biology Research
Eye Defects
Growth Defects

Neurobiology Research
Cerebellar Defects (Purkinje cell defect)
Neurodegeneration
Tremor Defects

Sensorineural Research
Eye Defects
Retinal Degeneration

Genes & Alleles

Gene & Allele Information

Allele Symbol		A^w-J
Allele Name		white bellied agouti Jackson
Allele Type		Spontaneous
Common Name(s)		A^WJ;
Strain of Origin		C57BL/6J
Gene Symbol and Name		a, nonagouti
Chromosome		2
Gene Common Name(s)		AGSW; AGTI; AGTIL; ASP; As; MGC126092; MGC126093; SHEP9; agouti; agouti signal protein; agouti suppressor;

Allele Symbol		Aifm1^Hq
Allele Name		harlequin
Allele Type		Spontaneous
Common Name(s)		Hq;
Strain of Origin		CF1
Gene Symbol and Name		Aifm1, apoptosis-inducing factor, mitochondrion-associated 1
Chromosome		X
Gene Common Name(s)		AIF; AIFsh2; Hq; MGC111425; PDCD8; Pdcd8; apoptosis-inducing factor; harlequin; programmed cell death 8;
General Note		Although initial reports were that ataxia was more severe in males than females, later unpublished reports indicate that there is no significant difference in severity of the ataxia phenotype between hemizygous males and homozygous females (S. Ackerman, personal communication)
Molecular Note		The harlequin mutation is an ecotropic proviral insertion at the Pdcd8 gene. This insertion leads to an 80% decrease in transcipt and protein levels, relative to wild-type controls. [MGI Ref ID J:78983]

Genotyping

Genotyping Information

Genotyping Protocols
A^w-J, STD PCR, vers. 1
Aifm1^Hq, SEP PCR, vers. 1

Helpful Links

Optimizing PCR Protocols

References

Selected Reference(s)

Klein JA; Longo-Guess CM; Rossmann MP; Seburn KL; Hurd RE; Frankel WN; Bronson RT; Ackerman SL. 2002. The harlequin mouse mutation downregulates apoptosis-inducing factor. Nature 419(6905):367-74. [PubMed: 12353028] [MGI Ref ID J:78983]

Additional References

Cregan SP; Fortin A; MacLaurin JG; Callaghan SM; Cecconi F; Yu SW; Dawson TM; Dawson VL; Park DS; Kroemer G; Slack RS. 2002. Apoptosis-inducing factor is involved in the regulation of caspase-independent neuronal cell death. J Cell Biol 158(3):507-17. [PubMed: 12147675] [MGI Ref ID J:78264]

Daugas E; Nochy D; Ravagnan L; Loeffler M; Susin SA; Zamzami N; Kroemer G. 2000. Apoptosis-inducing factor (AIF): a ubiquitous mitochondrial oxidoreductase involved in apoptosis FEBS Lett 476(3):118-23. [PubMed: 10913597] [MGI Ref ID J:63402]

Joza N; Susin SA; Daugas E; Stanford WL; Cho SK; Li CY; Sasaki T; Elia AJ; Cheng HY; Ravagnan L; Ferri KF; Zamzami N; Wakeham A; Hakem R; Yoshida H; Kong YY; Mak TW; Zuniga-Pflucker JC; Kroemer G; Penninger JM. 2001. Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death. Nature 410(6828):549-54. [PubMed: 11279485] [MGI Ref ID J:68434]

Loeffler M; Daugas E; Susin SA; Zamzami N; Metivier D; Nieminen AL; Brothers G; Penninger JM; Kroemer G. 2001. Dominant cell death induction by extramitochondrially targeted apoptosis-inducing factor. FASEB J 15(3):758-67. [PubMed: 11259394] [MGI Ref ID J:67944]

Susin SA; Daugas E; Ravagnan L; Samejima K; Zamzami N; Loeffler M; Costantini P; Ferri KF; Irinopoulou T; Prevost MC; Brothers G; Mak TW; Penninger J; Earnshaw WC; Kroemer G. 2000. Two distinct pathways leading to nuclear apoptosis. J Exp Med 192(4):571-80. [PubMed: 10952727] [MGI Ref ID J:64229]
A^w-J related

Aberg T; Wang XP; Kim JH; Yamashiro T; Bei M; Rice R; Ryoo HM; Thesleff I. 2004. Runx2 mediates FGF signaling from epithelium to mesenchyme during tooth morphogenesis. Dev Biol 270(1):76-93. [PubMed: 15136142] [MGI Ref ID J:92174]

Barsh GS; Epstein CJ. 1989. Physical and genetic characterization of a 75-kilobase deletion associated with al, a recessive lethal allele at the mouse agouti locus. Genetics 121(4):811-8. [PubMed: 2566558] [MGI Ref ID J:9799]

Baurle J; Vogten H; Grusser-Cornehls U. 1998. Course and targets of the calbindin D-28k subpopulation of primary vestibular afferents. J Comp Neurol 402(1):111-28. [PubMed: 9831049] [MGI Ref ID J:118430]

Boran T; Lesot H; Peterka M; Peterkova R. 2005. Increased apoptosis during morphogenesis of the lower cheek teeth in tabby/EDA mice. J Dent Res 84(3):228-33. [PubMed: 15723861] [MGI Ref ID J:112546]

Cui CY; Hashimoto T; Grivennikov SI; Piao Y; Nedospasov SA; Schlessinger D. 2006. Ectodysplasin regulates the lymphotoxin-beta pathway for hair differentiation. Proc Natl Acad Sci U S A 103(24):9142-7. [PubMed: 16738056] [MGI Ref ID J:111051]

Cui CY; Kunisada M; Esibizione D; Grivennikov SI; Piao Y; Nedospasov SA; Schlessinger D. 2007. Lymphotoxin-beta regulates periderm differentiation during embryonic skin development. Hum Mol Genet 16(21):2583-90. [PubMed: 17673451] [MGI Ref ID J:129949]

Dickie MM. 1969. Mutations at the agouti locus in the mouse. J Hered 60(1):20-5. [PubMed: 5798139] [MGI Ref ID J:30922]

Granholm DE; Reese RN; Granholm NH. 1996. Agouti alleles alter cysteine and glutathione concentrations in hair follicles and serum of mice (A y/a, A wJ/A wJ, and a/a). J Invest Dermatol 106(3):559-63. [PubMed: 8648194] [MGI Ref ID J:32132]

Granholm DE; Reese RN; Granholm NH. 1995. Agouti alleles influence thiol concentrations in hair follicles and extrafollicular tissues of mice (Ay/a, AwJ/AwJ, a/a). Pigment Cell Res 8(6):302-6. [PubMed: 8789738] [MGI Ref ID J:31403]

Jones JM; Huang JD; Mermall V; Hamilton BA; Mooseker MS; Escayg A; Copeland NG; Jenkins NA; Meisler MH. 2000. The mouse neurological mutant flailer expresses a novel hybrid gene derived by exon shuffling between Gnb5 and Myo5a. Hum Mol Genet 9(5):821-8. [PubMed: 10749990] [MGI Ref ID J:61324]

Kappenman KE; Dvoracek MA; Harvison GA; Fuller BB; Granholm NH. 1992. Tyrosinase abundance and activity in murine hairbulb melanocytes of agouti mutants (C57BL/6J-a/a, Ay/a, and AwJ/AwJ). Pigment Cell Res Suppl 2:79-83. [PubMed: 1409442] [MGI Ref ID J:1295]

Katoh A; Yoshida T; Himeshima Y; Mishina M; Hirano T. 2005. Defective control and adaptation of reflex eye movements in mutant mice deficient in either the glutamate receptor delta2 subunit or Purkinje cells. Eur J Neurosci 21(5):1315-26. [PubMed: 15813941] [MGI Ref ID J:101081]

Lee M; Kim A; Chua SC Jr; Obici S; Wardlaw SL. 2007. Transgenic MSH overexpression attenuates the metabolic effects of a high-fat diet. Am J Physiol Endocrinol Metab 293(1):E121-31. [PubMed: 17374695] [MGI Ref ID J:126508]

Lu W; Tsirka SE. 2002. Partial rescue of neural apoptosis in the Lurcher mutant mouse through elimination of tissue plasminogen activator. Development 129(8):2043-50. [PubMed: 11934869] [MGI Ref ID J:111363]

Mayer TC; Fishbane JL. 1972. Mesoderm-ectoderm interaction in the production of the agouti pigmentation pattern in mice. Genetics 71(2):297-303. [PubMed: 4558326] [MGI Ref ID J:5288]

Mitsumori K; Yasuhara K; Mori I; Hayashi S; Shimo T; Onodera H; Nomura T; Hayashi Y. 1998. Pulmonary fibrosis caused by N-methyl-N-nitrosourethane inhibits lung tumorigenesis by urethane in transgenic mice carrying the human prototype c-Ha-ras gene. Cancer Lett 129(2):181-90. [PubMed: 9719460] [MGI Ref ID J:52138]

Monroe DG; Wipf LP; Diggins MR; Matthees DP; Granholm NH. 1998. Agouti-related maturation and tissue distribution of alpha-Melanocyte Stimulating Hormone in wild-type (AwJ/AwJ) and mutant (Ay/a,a/a) mice. Pigment Cell Res 11(5):310-3. [PubMed: 9877102] [MGI Ref ID J:52183]

Mullen RJ. 1974. A<w-J> - white-bellied agouti-J Mouse News Lett 50:38. [MGI Ref ID J:64104]

Mustonen T; Ilmonen M; Pummila M; Kangas AT; Laurikkala J; Jaatinen R; Pispa J; Gaide O; Schneider P; Thesleff I; Mikkola ML. 2004. Ectodysplasin A1 promotes placodal cell fate during early morphogenesis of ectodermal appendages. Development 131(20):4907-19. [PubMed: 15371307] [MGI Ref ID J:128256]

O'donnell SM; Hansberger MW; Connolly JL; Chappell JD; Watson MJ; Pierce JM; Wetzel JD; Han W; Barton ES; Forrest JC; Valyi-Nagy T; Yull FE; Blackwell TS; Rottman JN; Sherry B; Dermody TS. 2005. Organ-specific roles for transcription factor NF-kappaB in reovirus-induced apoptosis and disease. J Clin Invest 115(9):2341-2350. [PubMed: 16100570] [MGI Ref ID J:100906]

Peng J; Wu Z; Wu Y; Hsu M; Stevenson FF; Boonplueang R; Roffler-Tarlov SK; Andersen JK. 2002. Inhibition of caspases protects cerebellar granule cells of the weaver mouse from apoptosis and improves behavioral phenotype. J Biol Chem 277(46):44285-91. [PubMed: 12221097] [MGI Ref ID J:119427]

Peng J; Xie L; Stevenson FF; Melov S; Di Monte DA; Andersen JK. 2006. Nigrostriatal dopaminergic neurodegeneration in the weaver mouse is mediated via neuroinflammation and alleviated by minocycline administration. J Neurosci 26(45):11644-51. [PubMed: 17093086] [MGI Ref ID J:114943]

Poole TW. 1975. Dermal-epidermal interactions and the action of alleles at the agouti locus in the mouse. Dev Biol 42(2):203-10. [PubMed: 1090472] [MGI Ref ID J:5519]

Probst FJ; Cooper ML; Cheung SW; Justice MJ. 2008. Genotype, phenotype, and karyotype correlation in the XO mouse model of Turner Syndrome. J Hered 99(5):512-7. [PubMed: 18499648] [MGI Ref ID J:138994]

Smith DE; Xu SG. 2003. Ultrastructural organization of GABA-like immunoreactive profiles in the weaver substantia nigra. J Neurocytol 32(3):293-303. [PubMed: 14724391] [MGI Ref ID J:121345]

Vandenput L; Swinnen JV; Boonen S; Van Herck E; Erben RG; Bouillon R; Vanderschueren D. 2004. Role of the androgen receptor in skeletal homeostasis: the androgen-resistant testicular feminized male mouse model. J Bone Miner Res 19(9):1462-70. [PubMed: 15312246] [MGI Ref ID J:111491]

Wu Q; Miller RH; Ransohoff RM; Robinson S; Bu J; Nishiyama A. 2000. Elevated levels of the chemokine GRO-1 correlate with elevated oligodendrocyte progenitor proliferation in the jimpy mutant. J Neurosci 20(7):2609-17. [PubMed: 10729341] [MGI Ref ID J:109469]

Yamago G; Takata Y; Furuta I; Urase K; Momoi T; Huh N. 2001. Suppression of hair follicle development inhibits induction of sonic hedgehog, patched, and patched-2 in hair germs in mice. Arch Dermatol Res 293(9):435-41. [PubMed: 11758785] [MGI Ref ID J:116953]

Yoshida T; Katoh A; Ohtsuki G; Mishina M; Hirano T. 2004. Oscillating Purkinje neuron activity causing involuntary eye movement in a mutant mouse deficient in the glutamate receptor delta2 subunit. J Neurosci 24(10):2440-8. [PubMed: 15014119] [MGI Ref ID J:97010]

van Empel VP; Bertrand AT; van der Nagel R; Kostin S; Doevendans PA; Crijns HJ; de Wit E; Sluiter W; Ackerman SL; De Windt LJ. 2005. Downregulation of apoptosis-inducing factor in harlequin mutant mice sensitizes the myocardium to oxidative stress-related cell death and pressure overload-induced decompensation. Circ Res 96(12):e92-e101. [PubMed: 15933268] [MGI Ref ID J:110278]

Aifm1^Hq related

Barber BR. 1971. Two new mutations Mouse News Lett 45:34-5. [MGI Ref ID J:15073]

Bronson RT; Lane PW; Harris BS; Davisson MT. 1990. Harlequin (Hq) produces progressive cerebellar cortical atrophy Mouse Genome 87:110. [MGI Ref ID J:79052]

Cheung EC; Melanson-Drapeau L; Cregan SP; Vanderluit JL; Ferguson KL; McIntosh WC; Park DS; Bennett SA; Slack RS. 2005. Apoptosis-inducing factor is a key factor in neuronal cell death propagated by BAX-dependent and BAX-independent mechanisms. J Neurosci 25(6):1324-34. [PubMed: 15703386] [MGI Ref ID J:98103]

Falconer DS; Isaacson. 1972. Harlequin and brindled - linkage, and difference between coupling and repulsion phenotypes Mouse News Lett 47:28. [MGI Ref ID J:13531]

Hisatomi T; Nakazawa T; Noda K; Almulki L; Miyahara S; Nakao S; Ito Y; She H; Kohno R; Michaud N; Ishibashi T; Hafezi-Moghadam A; Badley AD; Kroemer G; Miller JW. 2008. HIV protease inhibitors provide neuroprotection through inhibition of mitochondrial apoptosis in mice. J Clin Invest 118(6):2025-38. [PubMed: 18497877] [MGI Ref ID J:137728]

Hogan ME; King LE Jr; Sundberg JP. 1995. Defects of pelage hairs in 20 mouse mutations. J Invest Dermatol 104(5 Suppl):31S-32S. [PubMed: 7738386] [MGI Ref ID J:25255]

Oppenheim RW; Blomgren K; Ethell DW; Koike M; Komatsu M; Prevette D; Roth KA; Uchiyama Y; Vinsant S; Zhu C. 2008. Developing postmitotic mammalian neurons in vivo lacking Apaf-1 undergo programmed cell death by a caspase-independent, nonapoptotic pathway involving autophagy. J Neurosci 28(6):1490-7. [PubMed: 18256270] [MGI Ref ID J:131954]

Stringer JR; Larson JS; Fischer JM; Stringer SL. 2004. Increased mutation in mice genetically predisposed to oxidative damage in the brain. Mutat Res 556(1-2):127-34. [PubMed: 15491640] [MGI Ref ID J:93783]

Sundberg JP (ed.). 1994. . In: Handbook of Mouse Mutations with Skin and Hair Abnormalities: Animal Models and Biomedical Tools. CRC Press, Boca Raton. [MGI Ref ID J:30359]

Vahsen N; Cande C; Briere JJ; Benit P; Joza N; Larochette N; Mastroberardino PG; Pequignot MO; Casares N; Lazar V; Feraud O; Debili N; Wissing S; Engelhardt S; Madeo F; Piacentini M; Penninger JM; Schagger H; Rustin P; Kroemer G. 2004. AIF deficiency compromises oxidative phosphorylation. EMBO J 23(23):4679-89. [PubMed: 15526035] [MGI Ref ID J:134036]

Zhu C; Wang X; Deinum J; Huang Z; Gao J; Modjtahedi N; Neagu MR; Nilsson M; Eriksson PS; Hagberg H; Luban J; Kroemer G; Blomgren K. 2007. Cyclophilin A participates in the nuclear translocation of apoptosis-inducing factor in neurons after cerebral hypoxia-ischemia. J Exp Med 204(8):1741-8. [PubMed: 17635954] [MGI Ref ID J:125956]

Zhu C; Wang X; Huang Z; Qiu L; Xu F; Vahsen N; Nilsson M; Eriksson PS; Hagberg H; Culmsee C; Plesnila N; Kroemer G; Blomgren K. 2007. Apoptosis-inducing factor is a major contributor to neuronal loss induced by neonatal cerebral hypoxia-ischemia. Cell Death Differ 14(4):775-84. [PubMed: 17039248] [MGI Ref ID J:134831]

van Empel VP; Bertrand AT; van der Nagel R; Kostin S; Doevendans PA; Crijns HJ; de Wit E; Sluiter W; Ackerman SL; De Windt LJ. 2005. Downregulation of apoptosis-inducing factor in harlequin mutant mice sensitizes the myocardium to oxidative stress-related cell death and pressure overload-induced decompensation. Circ Res 96(12):e92-e101. [PubMed: 15933268] [MGI Ref ID J:110278]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports
Room Number FGB29

Colony Maintenance

Breeding & Husbandry Comments: Hq/Y males need to stay with their mothers an extra week or more because they are too small to wean at 3 weeks.

Diet Information LabDiet® 5K52/5K67

Breeding & Husbandry	Comments: Hq/Y males need to stay with their mothers an extra week or more because they are too small to wean at 3 weeks.
Diet Information	LabDiet® 5K52/5K67

Weeks of Age	Price*	Gender	Genotypes Provided
Individual Mouse Price	$121.50	Male	Hemizygous for Aifm1^Hq
	$127.90	Female	Heterozygous for Aifm1^Hq

Pairs /Price*	Pair Genotype
$249.40	Heterozygous for Aifm1^Hq x Hemizygous for Aifm1^Hq
$180.15	Heterozygous for Aifm1^Hq x Wild-type for Aifm1^Hq

Supply Notes	Histology and Tissue Collection Services are available for all JAX^® Mice strains. For more information, please contact Customer Service at orderquest@jax.org or 1-800-422-6423.

Weeks of Age	Price*	Gender	Genotypes Provided
Individual Mouse Price	$158.00	Male	Hemizygous for Aifm1^Hq
	$166.30	Female	Heterozygous for Aifm1^Hq

Pairs /Price*	Pair Genotype
$324.30	Heterozygous for Aifm1^Hq x Hemizygous for Aifm1^Hq
$234.20	Heterozygous for Aifm1^Hq x Wild-type for Aifm1^Hq

Supply Notes	Histology and Tissue Collection Services are available for all JAX^® Mice strains. For more information, please contact Customer Service at orderquest@jax.org or 1-207-288-5845.

Standard Supply	Repository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of ~nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within 48 hours of order placement.
Supply Notes	Usually shipped between four and eight weeks of age. Genomic DNA is available for this strain from the Mouse DNA Resource.

Repository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of ~nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within 48 hours of order placement.

Supply Notes

Usually shipped between four and eight weeks of age.
Genomic DNA is available for this strain from the Mouse DNA Resource.

Control Information

	Control
	Wild-type from the colony

Considerations for Choosing Controls
USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains.
International - Control Pricing Information for Genetically Engineered Mutant Strains.

General Terms and Conditions

See Terms of Use

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

Ordering and Purchasing Information

Purchasing Information
JAX^® Mice Orders
Surgical Services

Contact Information
Orders & Technical Support
Tel: 800.422.6423 or 207.288.5845
Fax: 207.288.6150
Technical Support Email Form

Terms of Use

General Terms and Conditions

Contact information

General inquiries

Contracts Administration

phone:	207-288-6470
fax:	207-288-6655

JAX^® Mice & Services Conditions of Use

“Each recipient institution, including its employees and other researchers under its control (RECIPIENT), of mice or services using mice from The Jackson Laboratory (TJL) agrees that such mice, descendants of those mice derived by inbreeding or crossbreeding, including unmodified derivatives of those mice or their descendants (“MICE”) shall not be: (i) used for any purpose other than the internal research of the RECIPIENT, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services with respect to MICE. Acceptance of MICE from TJL shall be deemed agreement by RECIPIENT to these conditions, and departure from these conditions requires The Jackson Laboratory’s prior written authorization.”

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The foregoing represents the General Terms and Conditions applicable to The Jackson Laboratory’s MICE, products and services. In addition, special terms and conditions of sale of certain MICE, products and services may be set forth separately in The Jackson Laboratory web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, products and services by The Jackson Laboratory, and by its licensees and distributors.

Acceptance of delivery of MICE, products or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on The Jackson Laboratory, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, products services by The Jackson Laboratory.

000202	AEJ/Gn-bd/J
000199	AEJ/GnLeJ
000593	B6 x B6CBCa A^w-J/A-Grid2^Lc T(2;6)7Ca Mitf^Mi-wh/J
000502	B6 x B6CBCa A^w-J/A-Myo5a^flr Gnb5^flr/J
000599	B6 x B6CBCa A^w-J/A-T(5;13)264Ca Kit^W-v/J
002016	B6(Cg)-A^w-J Eda^Ta-6J Chr Y^B6-Sxr/EiJ
000552	B6-A^w-J-Eda^Ta-6J.Cg-Sxr
001730	B6-A^w-J-Eda^Ta-6J.Cg-Sxr^b Hya^-/J
000841	B6-A^w-J.CBy-Eda^Ta-By/J
001809	B6-A^w-J.Cg-Eda^Ta-6J +/+ Ar^Tfm/J
000600	B6-Gpi1^b x B6CBCa A^w-J/A-T(7;15)9H Gpi1^a/J
100409	B6129PF1/J-A^w-J/A^w
004200	B6;CBACa A^w-J/A-Npr2^cn-2J/J
000505	B6C3 A^w-J/A-Muted^mu/J
000314	B6CBACa A^w-J/A-Eda^Ta/J-XO
001046	B6CBACa A^w-J/A-Grid2^Lc/J
000500	B6CBACa A^w-J/A-Gs/J
002703	B6CBACa A^w-J/A-Hydin^hy3/J
000247	B6CBACa A^w-J/A-Kcnj6^wv/J
000287	B6CBACa A^w-J/A-Plp1^jp Eda^Ta/J
000515	B6CBACa A^w-J/A-Sfn^Er/J
000242	B6CBACa A^w-J/A-spc/J
000288	B6CBACa A^w-J/A-we a Mafb^kr/J
001201	B6CBACaF1/J-A^w-J/A
001752	B6CBCa A^w-J/A-T(7;15)9H/J
000200	C3FeB6 A/A^w-J-Ank^ank/J
000638	C3FeB6 A/A^w-J-Spnb4^qv-J/J
001203	C3FeB6F1/J A/A^w-J
000338	C57BL/6J A^w-J-Eda^Ta-6J/J
000569	C57BL/6J-A^w-J-Eda^Ta +/+ Ar^Tfm/J
000051	C57BL/6J-A^w-J/J

003301	(C57BL/6J x C3H-Eya1^bor)F1/J
000251	AEJ.Cg-a^e +/a Gdf5^bp-H/J
000202	AEJ/Gn-bd/J
000199	AEJ/GnLeJ
000427	B10.CE-H13^b A^w/(30NX)SnJ
000420	B10.LP-H13^b A^w/Sn
000477	B10.PA-Pldn^pa H3^e a^t/SnJ
000419	B10.UW-H3^b we Pax1^un a^t/SnJ
003879	B10;TFLe-a/a T tf/+ tf/J
001538	B6 x B6C3Sn a/A-T(1;9)27H/J
000916	B6 x B6C3Sn a/A-T(5;12)31H/J
000602	B6 x B6C3Sn a/A-T(8;16)17H/J
002083	B6 x B6EiC3 a/A-T(7;16)235Dn/J
000507	B6 x B6EiC3 a/A-Otc^spf/J
000618	B6 x FSB/GnEi a/a Ctsl^fs/J
000577	B6 x STOCK a Oca2^p Hps5^ru2 Ednrb^s/J
000601	B6 x STOCK a/a T(7;18)50H/J
000592	B6 x STOCK T(2;4)13H a/J
000769	B6.C/(HZ18)By-a^t-44J/J
000001	B6.C3 A/a Mgrn1^md/J
000203	B6.C3-A^iy/a/J
001572	B6.C3-a^m-J/J
000017	B6.C3Fe-A^vy/J
000628	B6.CE-A Amy1^b Amy2^b/J
005505	B6.Cg-A^y Slc7a11^sut/LmLlp
000021	B6.Cg-A^y/J
004200	B6;CBACa A^w-J/A-Npr2^cn-2J/J
000785	B6;D2-a Es1^e/J
000604	B6C3 a/A-T(10;13)199H +/+ Lyst^bg-J/J or Lyst^bg-2J/J
002807	B6C3Fe a/a-Meox2^fla/J
000224	B6C3Fe a/a-Scyl1^mdf/J
001037	B6C3Fe a/a-Agtpbp1^pcd/J
000221	B6C3Fe a/a-Alx4^lst-J/J
002062	B6C3Fe a/a-Atp7a^Mo-8J/J
001756	B6C3Fe a/a-Cacng2^stg/J
001815	B6C3Fe a/a-Col1a2^oim/J
000231	B6C3Fe a/a-Csf1^op/J
000209	B6C3Fe a/a-Dh/J
000211	B6C3Fe a/a-Dst^dt-J/J
000210	B6C3Fe a/a-Edar^dl-J/J
000207	B6C3Fe a/a-Edaradd^cr/J
000182	B6C3Fe a/a-Eef1a2^wst/J
001278	B6C3Fe a/a-Glra1^spd/J
000241	B6C3Fe a/a-Glrb^spa/J
002875	B6C3Fe a/a-Hoxd13^spdh/J
000304	B6C3Fe a/a-Krt71^Ca Scn8a^med-J/J
000226	B6C3Fe a/a-Large^myd/J
000636	B6C3Fe a/a-Lmx1a^dr-J/J
001280	B6C3Fe a/a-Lse/J
001573	B6C3Fe a/a-Mitf^Mi/J
001035	B6C3Fe a/a-Napa^hyh/J
000181	B6C3Fe a/a-Otog^twt/J
000278	B6C3Fe a/a-Papss2^bm Hps1^ep Hps6^ru/J
000205	B6C3Fe a/a-Papss2^bm/J
002078	B6C3Fe a/a-Pcdh15^av-2J/J
000246	B6C3Fe a/a-Pitpna^vb/J
001430	B6C3Fe a/a-Ptch1^mes/J
000506	B6C3Fe a/a-Qk^qk/J
000235	B6C3Fe a/a-Reln^rl/J
000237	B6C3Fe a/a-Rora^sg/J
000290	B6C3Fe a/a-Sox10^Dom/J
000230	B6C3Fe a/a-Tcirg1^oc/J
003612	B6C3Fe a/a-Trak1^hyrt/J
001512	B6C3Fe a/a-Ttn^mdm/J
001607	B6C3Fe a/a-Unc5c^rcm/J
000005	B6C3Fe a/a-Wc/J
000243	B6C3Fe a/a-Wnt1^sw/J
000248	B6C3Fe a/a-Xpl/J
001750	B6C3Fe a/a-Xs^J/J
000624	B6C3Fe a/a-anx/J
003020	B6C3Fe a/a-dep/J
002018	B6C3Fe a/a-din/J
002339	B6C3Fe a/a-nma/J
000240	B6C3Fe a/a-soc/J
000063	B6C3Fe a/a-sy/J
001055	B6C3Fe a/a-tip/J
000245	B6C3Fe a/a-tn/J
000065	B6C3Fe a/a-we Pax1^un a^t/J
000296	B6C3Fe-a/a Hoxa13^Hd Mcoln3^Va-J/J
000019	B6C3Fe-a/a-Itpr1^opt/J
001022	B6C3FeF1/J a/a
001752	B6CBCa A^w-J/A-T(7;15)9H/J
000971	B6EiC3 a/A-Och/J
000551	B6EiC3 a/A-Tbx15^de-H/J
006450	B6EiC3 a/A-Vss/J
000557	B6EiC3-+ a/Lnp^Ul A/J
000504	B6EiC3Sn a/A-Cacnb4^lh/J
000553	B6EiC3Sn a/A-Egfr^wa2 Wnt3a^vt/J
000503	B6EiC3Sn a/A-Gy/J
001811	B6EiC3Sn a/A-Otc^spf-ash/J
002343	B6EiC3Sn a/A-Otc^spf/J
000391	B6EiC3Sn a/A-Pax6^Sey-Dey/J
001924	B6EiC3Sn a/A-Ts(17¹⁶)65Dn
001923	B6EiC3Sn a/A-Ts(4¹⁷)2Lws Tim/J
000200	C3FeB6 A/A^w-J-Ank^ank/J
000638	C3FeB6 A/A^w-J-Spnb4^qv-J/J
000225	C3FeLe.B6 a/a-Ptpn6^me/J
008425	C3FeLe.B6-a Trl/J
000198	C3FeLe.B6-a/J
000291	C3FeLe.Cg-a/a Hm Kitl^Sl Krt71^Ca-J/J
001272	C3H/HeSnJ-A^hvy/J
000099	C3HeB/FeJ-A^vy/J
001886	C3HeB/FeJLe a/a-gnd/J
000584	C57BL/6J-+ T(1;2)5Ca/a +/J
000258	C57BL/6J-Aⁱ/a/J
000774	C57BL/6J-A^sy/a/J
000055	C57BL/6J-a^t-33J/J
000070	C57BL/6J-a^td/J
000284	CWD/LeJ
000670	DBA/1J
000671	DBA/2J
001057	HPT/LeJ
000260	JGBF/LeJ
002468	KK.Cg-A^y/J
000262	LS/LeJ
000283	LT.CAST-A/J
000265	MY/HuLeJ
000308	SSL/LeJ
001759	STOCK A Tyr^c Sha/J
001427	STOCK A^w us/J
000994	STOCK a Myo5a^d Mreg^dsu/J
000064	STOCK a Tyrp1^b Si^si/J
002238	STOCK a Tyrp1^b shmy/J
001433	STOCK a skt/J
000579	STOCK a tp/J
000319	STOCK a us/J
002648	STOCK a/a Cln6^nclf/J
000317	STOCK a/a Egfr^wa2/J
000302	STOCK a/a Mitf^Mi-wh +/+ Itpr1^opt/J
000286	STOCK a/a Myo5a^d fd/+ +/J
000206	STOCK a/a Tyr^c-h/J
001432	STOCK a/a Tyrp1^b sks/Tyrp1^b +/J
000281	STOCK a/a ma ft/ma ft/J
000312	STOCK stb + a/+ Fign^fi a/J
000596	STOCK T(2;11)30H/+ x AEJ-a Gdf5^bp-H/J or A/J-a Gdf5^bp-J/J
000970	STOCK T(2;16)28H A/T(2;16)28H a/J
000590	STOCK T(2;4)1Sn a/J
000594	STOCK T(2;8)26H a/T(2;8)26H a Tyrp1⁺/Tyrp1^b/J
000623	TR/DiEiJ

Strain Name:

B6CBACa Aw-J/A-Aifm1Hq/J

Stock Number:

000501

Availability:

Repository- Live

Strain Information

Control Information

Related Strains

Additional Web Information

Phenotype Information

Aifm1Hq/Aifm1+

Aifm1Hq/Aifm1Hq

Aifm1Hq/Y

Aifm1Hq/Aifm1Hq

Aifm1Hq/Y

Gene & Allele Information

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See Terms of Use

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JAX® Mice & Services Conditions of Use

No Warranty

No Liability

B6CBACa A^w-J/A-Aifm1^Hq/J

Aifm1^Hq/Aifm1⁺

Aifm1^Hq/Aifm1^Hq

Aifm1^Hq/Y

Aifm1^Hq/Aifm1^Hq

Aifm1^Hq/Y

JAX^® Mice & Services Conditions of Use