Strain Name: |
B6 x B6CBCa Aw-J/A-Myo5aflr Gnb5flr/J |
|---|---|
Stock Number: |
000502 |
Availability: | Repository-Cryopreserved |
General Terms and Conditions |
| Former Name |
B6 x B6CBACa-Aw-J/A-Myo5aflr Gnb5flr (Changed: 15-DEC-04
) |
| Genes & Alleles | Aw-J; Gnb5; Gnb5flr; Myo5a; Myo5aflr; a; |
Type JAX® GEMM® Strain - Mutant Stock Additional information on JAX® GEMM® Strains. Species laboratory mouse Generation N1 f3+N1 Strain Development
The flailer mutation arose spontaneously on the C57BL/10J background at The Jackson Laboratory in 1971. It was initially named tumbler 2 Jackson because it resembled the tumbler mutation. However, these mutations are not allelic, and tumbler maps to chromosome 1 while flailer occurred in Chromosome 9. The flailer mutation was maintained for many years by outcrossing a homozygote to B6CBACaF1/J Aw-J/A then intercrossing the obligate heterozygous offspring. In 1983 C57BL/6J females were bred with B6CBACa Aw-J/A-Myo5aflr Gnb5flr/J heterozygous males, ranging in generation from N17F1 to N17F3, to generate embryos for cryopreservation.
Mammalian Phenotype Terms assigned by genotype |
| Allele Symbol | Aw-J | ||
|---|---|---|---|
| Allele Name | white bellied agouti Jackson | ||
| Common Name(s) | AWJ; | ||
| Strain of Origin | C57BL/6J | ||
| Gene Symbol and Name | a, nonagouti | ||
| Chromosome | 2 | ||
| Gene Common Name(s) | AGSW; AGTI; AGTIL; ASP; As; MGC126092; MGC126093; SHEP9; agouti; agouti signal protein; agouti suppressor; | ||
| Allele Symbol | Gnb5flr | ||
| Allele Name | flailer | ||
| Common Name(s) | flail; flr; tb2J; | ||
| Strain of Origin | C57BL/10J x B6CBA/Ca | ||
| Gene Symbol and Name | Gnb5, guanine nucleotide binding protein (G protein), beta 5 | ||
| Chromosome | 9 | ||
| Gene Common Name(s) | FLJ37457; FLJ43714; G beta 5; GB5; Gbeta5; MGC105255; flail; flailer; flr; | ||
| General Note |
The flailer mutation, originally called tb2J, was a presumed remutation of tb because of a similar phenotype. This mutation, however, does not map to Chr 1, and the original unpublished report of linkage of tb to Chr 1 is in doubt. Thus, it isnot clear whether tb2J is a remutation at the tb locus which was not on Chr 1, or if tb2J is a new mutation at a different locus. Because of its linkage to a different chromosome, tb2J was renamed flr. flr mutants have a variable neurological phenotype. Half of all flailer homozygotes show severe ataxia and only live for 3 weeks; these mutants tend to fall over and flail their limbs in an effort to right themselves. The other half of flailer homozygotes, however, only develop a transient ataxia; they recover, are fertile, and have a normal life span. | ||
| Molecular Note | Hybrid. This mutation is caused by gene shuffling between Gnb5 and Myo5a. The shuffling combines the promoter of the first two exons of Gnb5 with the C-terminal exons of Myo5a. Flailer homozygotes express transcripts of three genes: wild-type Gnb5, wild-type Myo5a and the flailer hybrid gene. [MGI Ref ID J:61324] | ||
| Allele Symbol | Myo5aflr | ||
| Allele Name | flailer | ||
| Common Name(s) | flail; flr; tb2J; | ||
| Strain of Origin | C57BL/10J | ||
| Gene Symbol and Name | Myo5a, myosin Va | ||
| Chromosome | 9 | ||
| Gene Common Name(s) | 9630007J19Rik; AI413174; AI661011; D; Dbv; Dop; GS1; MVa; MYH12; MYO5; MYR12; Myo5; MyoVA; RIKEN cDNA 9630007J19 gene; d; dilute; expressed sequence AI413174; expressed sequence AI661011; flail; flailer; flr; myosin V; nmf244; | ||
| Molecular Note | Hybrid. This mutation is caused by gene shuffling between Gnb5 and Myo5a. The shuffling combines the promoter of the first two exons of Gnb5 with the C-terminal exons of Myo5a. Flailer homozygotes express transcripts of three genes: wild-type Gnb5, wild-type Myo5a and the flailer hybrid gene. [MGI Ref ID J:61324] | ||
Aw-J
Strains carrying Aw-J allele
View Strains carrying Aw-J (31 strains)
Strains carrying other alleles of Myo5a
005012 A.B6 Tyr+-Myo5ad-l31J/J 001005 AKXD1/TyJ 001003 AKXD11/TyJ 000765 AKXD13/TyJ 000779 AKXD14/TyJ 000954 AKXD15/TyJ 001093 AKXD18/TyJ 000776 AKXD2/TyJ 001062 AKXD21/TyJ 000947 AKXD22/TyJ 000949 AKXD25/TyJ 000764 AKXD27/TyJ 000959 AKXD3/TyJ 001013 B10.D2/nSnJ-Myo5ad-n/J 000285 B6.Cg-Rorasg + +/+ Myo5ad Bmp5se/J 000652 BDP/J 000036 BXD1/TyJ 000013 BXD16/TyJ 000015 BXD18/TyJ 000010 BXD19/TyJ 000077 BXD21/TyJ 000043 BXD22/TyJ 000081 BXD25/TyJ 006255 BXD25/TyJRwwJ 000029 BXD29/TyJ 000037 BXD5/TyJ 000007 BXD6/TyJ 000084 BXD8/TyJ 000105 BXD9/TyJ 000284 CWD/LeJ 000670 DBA/1J 000671 DBA/2J 000963 DBA/2J-Myo5ad+17J/Myo5ad/J 000964 DBA/2J-Myo5ad+18J/Myo5ad/J 000067 DBA/2J-Myo5ad+2J/Myo5ad/J 000253 DLS/LeJ 000673 HRS/J 000674 I/LnJ 001850 MEV-Q/TyJ 001855 MEV-V/TyJ 003345 MEV/2Ty-Emv64/J 000679 P/J 000644 SEA/GnJ 000390 STOCK Myo5ad Ds/J 000994 STOCK a Myo5ad Mregdsu/J 000286 STOCK a/a Myo5ad fd/+ +/J View Strains carrying other alleles of Myo5a (46 strains)
Strains carrying other alleles of a
View Strains carrying other alleles of a (138 strains)
Gnb5flr related
Myo5aflr relatedNeurobiology Research
Ataxia (Movement) Defects
Ataxia (Movement) Defects
| Strain Name: | B6 x B6CBCa Aw-J/A-Myo5aflr Gnb5flr/J |
| Stock Number: | 000502 |
IMPORTANT NOTE: Prices are based on shipping destination. To view prices, select your shipping destination.
| Standard Supply | Repository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information. |
|---|---|
| Supply Notes |
Cryorecovery of Strains Needing Progeny Testing. The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two untested males and two untested females (two pairs) will be recovered, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the overall recovery time to approximately 25 weeks. However, all pups recovered will be sent. Progeny testing is required to identify the genotype of mice of this strain, as a genotyping assay is not available. This type of testing involves breeding the recovered animals and assessing the phenotype of the offspring in order to identify animals carrying the mutation of interest. We can perform the progeny testing for you as a service or we can ship all recovered animals (at least two untested pairs) to you for progeny testing at your facility. If you perform the progeny testing, there is NO guarantee that a carrier will be identified. If we perform progeny testing as a service, additional breeding time will be required. In this case, when a male and female (one pair) are identified that carry the mutation, they and their offspring will be shipped. Delivery time for strains requiring progeny testing often exceeds 25 weeks and may take 12 months or more due to the difficulties in breeding some strains. The progeny testing cost is in addition to the recovery cost and is based on the number of boxes used and the time taken to produce the mice identified as carrying the mutation. Please note that identified pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Please contact Customer Service for more information on the cost of progeny testing for a strain: Tel: 1-800-422-6423 or 1-207-288-5845. Cryorecovery to establish a Dedicated Supply for greater quantities of mice |
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