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- Description
- Phenotype
- Genes & alleles
- Genotyping
- Health & husbandry
- References
- Purchasing information
- Terms of Use
Description
The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.
Strain Information
Former Names B6EiC3Sn-a/A-PhexGy (Changed: 15-DEC-04 ) Type Mutant Stock; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Species laboratory mouse Generation N47p Appearance
black, circling
Related Genotype: a/a Gy/+
black, unaffected
Related Genotype: a/a +/+
agouti, circling
Related Genotype: A/? Gy/+
agouti, unaffected
Related Genotype: A/? +/+Description
Gyro (Gy) is an X-linked dominant mutation that causes circling behavior and defects in phospate metabolism. It is allelic with the hypophosphatemia mutation (PhexHyp). Hemizygous males and heterozygous females are characterized by hypophosphatemia, rickets, circling behavior, and inner ear abnormalities. Affected males are also sterile.
Control Information
| Control | ||
|---|---|---|
| Wild-type from the colony | ||
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying a allele
View Strains carrying a (104 strains)
Phenotype
Phenotype Information
assigned by genotype
Gy/Gy+
involves: C3H/Sn * C57BL/6Ei
- growth/size phenotype
- abnormal postnatal growth/weight/body size (MGI Ref ID J:88352)
- all females have a squared trunk
- limbs/digits/tail phenotype
- abnormal hindlimb morphology (MGI Ref ID J:88352)
- shortened hind limbs are seen
- short tail (MGI Ref ID J:88352)
Gy/Y
involves: C3H/Sn * C57BL/6Ei
- adipose tissue phenotype
- decreased adipose tissue amount (MGI Ref ID J:88352)
- a significant increase in lean body mass is seen compared to control
- growth/size phenotype
- decreased body weight (MGI Ref ID J:88352)
- all males have significantly lower body weights (~50% less than controls) and a squared trunk
- male Gy mutants weigh significantly less than other PhexHyp male mutants (PhexHyp, PhexHyp-2J, PhexHyp-Duk)
- hearing/vestibular/ear phenotype
- decreased brainstem auditory evoked potential (MGI Ref ID J:88352)
- mean auditory brainstem response thresholds are significantly higher than controls
- homeostasis/metabolism phenotype
- decreased circulating potassium level (MGI Ref ID J:88352)
- at 6 weeks of age serum PO4 levels are significantly lower than controls
- hypocalcemia (MGI Ref ID J:88352)
- at 6 weeks of age serum Ca2+ are significantly decreased compared to controls
- limbs/digits/tail phenotype
- abnormal hindlimb morphology (MGI Ref ID J:88352)
- shortened hind limbs are seen
- abnormal skeleton extremities morphology (MGI Ref ID J:88352)
- abnormal patella morphology (MGI Ref ID J:88352)
- growth plates of the knee are thickened and irregular
- decreased length of long bones (MGI Ref ID J:88352)
- the long bones are shortened
- short femur (MGI Ref ID J:88352)
- short fibula (MGI Ref ID J:88352)
- the fibula is shortened and splayed
- short tibia (MGI Ref ID J:88352)
- the tibia is shortened and splayed
- disorganized long bone epiphyseal plate (MGI Ref ID J:88352)
- disorganized femoral growth plates
- increased diameter of long bones (MGI Ref ID J:88352)
- the long bones are thickened
- short tail (MGI Ref ID J:88352)
- skeleton phenotype
- abnormal skeleton extremities morphology (MGI Ref ID J:88352)
- abnormal patella morphology (MGI Ref ID J:88352)
- growth plates of the knee are thickened and irregular
- decreased length of long bones (MGI Ref ID J:88352)
- the long bones are shortened
- short femur (MGI Ref ID J:88352)
- short fibula (MGI Ref ID J:88352)
- the fibula is shortened and splayed
- short tibia (MGI Ref ID J:88352)
- the tibia is shortened and splayed
- disorganized long bone epiphyseal plate (MGI Ref ID J:88352)
- disorganized femoral growth plates
- increased diameter of long bones (MGI Ref ID J:88352)
- the long bones are thickened
- decreased bone density (MGI Ref ID J:88352)
- between 6 and 40 weeks of age under-mineralized bone is present throughout the body
This mouse can be used to support research in many areas including:Gy related
Endocrine Deficiency Research
Bone/Bone Marrow Defects
Mouse/Human Gene Homologs
hypophosphatemic D-resistant rickets, X-linked
Neurobiology Research
Vestibular and Hearing Defects
Sensorineural Research
Vestibular and Hearing Defects
Genes & Alleles
Gene & Allele Information
| Allele Symbol | Gy | ||
|---|---|---|---|
| Allele Name | gyro | ||
| Allele Type | Radiation induced | ||
| Common Name(s) | PhexGy; | ||
| Strain of Origin | (C3H/HeH x 101/H)F1 | ||
| Gene Symbol and Name | Gy, gyro deletion region | ||
| Chromosome | X | ||
| General Note |
Gyro was identified at Harwell as a dominant mutation causing circling behavior among offspring of an irradiated female (J:28887). Hemizygous males are hypophosphatemic, have rickets/osteomalacia, exhibit circling behavior and inner ear abnormalities,and are sterile; heterozygous females show milder symptoms (J:8335). Gy and PhexHyp have very similar effects on serum phosphorus levels and on phosphate transport (J:8335). Secondary hyperparathyroidism, a feature of PhexHyp mice and of some human hypophosphatemics, is also found in Gy mice (J:26058). Defects in renal phosphate transport are found in both types of mice (J:1824) and are mediated via the sodium-phosphate transporter expression pathway in both. However, the molecular defect differs, a different step in the expression pathway being disrupted in Gy mice than in PhexHyp animals (J:33265). Gy and PhexHyp mice of both sexes failed to absorb Ca2+ solution injected into suture-isolated duodenum (J:17152). Both mouse mutants have abnormal vitamin D metabolism (J:24017,J:1824), and both show femoral and craniofacial bone abnormalities (J:24017, J:1654). | ||
| Molecular Note | The phenotype of the gyro mouse has been attributed to a deletion of ~160-190 kb, that includes the Sms gene as well as the first three exons and the promoter of the Phex gene. [MGI Ref ID J:38621] [MGI Ref ID J:46360] [MGI Ref ID J:47232] | ||
| Allele Symbol | a | ||
| Allele Name | nonagouti | ||
| Allele Type | Spontaneous | ||
Genotyping
Genotyping Information
This strain will not have a genotyping protocol or one is not currently available.
Helpful Links
Genotyping resources and troubleshooting
References
References
Additional References
Lyon MF; Scriver CR; Baker LR; Tenenhouse HS; Kronick J; Mandla S. 1986. The Gy mutation: another cause of X-linked hypophosphatemia in mouse. Proc Natl Acad Sci U S A 83(13):4899-903. [PubMed: 3460077] [MGI Ref ID J:8335]
Meyer RA Jr; Henley CM; Meyer MH; Morgan PL; McDonald AG; Mills C ; Price DK. 1998. Partial deletion of both the spermine synthase gene and the Pex gene in the X-linked hypophosphatemic, gyro (Gy) mouse. Genomics 48(3):289-95. [PubMed: 9545633] [MGI Ref ID J:47232]
Strom TM; Francis F; Lorenz B; Boddrich A; Econs MJ; Lehrach H ; Meitinger T. 1997. Pex gene deletions in Gy and Hyp mice provide mouse models for X-linked hypophosphatemia. Hum Mol Genet 6(2):165-71. [PubMed: 9063736] [MGI Ref ID J:38621]
Gy relatedBeck L; Tenenhouse HS; Meyer RA; Meyer MH; Biber J; Murer H. 1996. Renal expression of Na+-phosphate cotransporter mRNA and protein: effect of the Gy mutation and low phosphate diet. Pflugers Arch 431(6):936-41. [PubMed: 8927512] [MGI Ref ID J:33927]
Carter TC; Lyon MF; Phillips RJ. 1960. The genetic sensitivity to X-rays of mouse foetal gonads Genet Res 1:351-5. [MGI Ref ID J:28887]
Collins JF; Ghishan FK. 1996. The molecular defect in the renal sodium-phosphate transporter expression pathway of Gyro (Gy) mice is distinct from that of hypophosphatemic (Hyp) mice. FASEB J 10(7):751-9. [PubMed: 8635692] [MGI Ref ID J:33265]
Lopatin AN; Shantz LM; Mackintosh CA; Nichols CG; Pegg AE. 2000. Modulation of potassium channels in the hearts of transgenic and mutant mice with altered polyamine biosynthesis. J Mol Cell Cardiol 32(11):2007-24. [PubMed: 11040105] [MGI Ref ID J:102674]
Lorenz B; Francis F; Gempel K; Boddrich A; Josten M; Schmahl W ; Schmidt J ; Lehrach H ; Meitinger T ; Strom TM. 1998. Spermine deficiency in Gy mice caused by deletion of the spermine synthase gene. Hum Mol Genet 7(3):541-7. [PubMed: 9467015] [MGI Ref ID J:46360]
Lorenz-Depiereux B; Guido VE; Johnson KR; Zheng QY; Gagnon LH; Bauschatz JD; Davisson MT; Washburn LL; Donahue LR; Strom TM; Eicher EM. 2004. New intragenic deletions in the Phex gene clarify X-linked hypophosphatemia-related abnormalities in mice. Mamm Genome 15(3):151-61. [PubMed: 15029877] [MGI Ref ID J:88352]
Lyon MF. 1960. Gy - gyro Mouse News Lett 22:30. [MGI Ref ID J:64263]
Lyon MF; Jarvis SE. 1980. Relation of gyro and hypophosphataemia Mouse News Lett 62:49. [MGI Ref ID J:13833]
Lyon MF; Scriver CR; Baker LR; Tenenhouse HS; Kronick J; Mandla S. 1986. The Gy mutation: another cause of X-linked hypophosphatemia in mouse. Proc Natl Acad Sci U S A 83(13):4899-903. [PubMed: 3460077] [MGI Ref ID J:8335]
Mackintosh CA; Pegg AE. 2000. Effect of spermine synthase deficiency on polyamine biosynthesis and content in mice and embryonic fibroblasts, and the sensitivity of fibroblasts to 1,3-bis-(2-chloroethyl)-N-nitrosourea Biochem J 351 Pt 2:439-47. [PubMed: 11023830] [MGI Ref ID J:65535]
Meyer RA Jr; Henley CM; Meyer MH; Morgan PL; McDonald AG; Mills C ; Price DK. 1998. Partial deletion of both the spermine synthase gene and the Pex gene in the X-linked hypophosphatemic, gyro (Gy) mouse. Genomics 48(3):289-95. [PubMed: 9545633] [MGI Ref ID J:47232]
Meyer RA Jr; Meyer MH; Gray RW; Bruns ME. 1995. Femoral abnormalities and vitamin D metabolism in X-linked hypophosphatemic (Hyp and Gy) mice. J Orthop Res 13(1):30-40. [PubMed: 7853101] [MGI Ref ID J:24017]
Meyer RA Jr; Meyer MH; Morgan PL. 1996. Effects of altered diet on serum levels of 1,25-dihydroxyvitamin D and parathyroid hormone in X-linked hypophosphatemic (Hyp and Gy) mice. Bone 18(1):23-8. [PubMed: 8717533] [MGI Ref ID J:36180]
Meyer RA; Morgan PL; Meyer MH. 1994. Measurement of parathyroid hormone in the mouse: secondary hyperparathyroidism in the X-linked hypophosphatemic (Gyro, gy) mouse. Endocrine 2(12):1127-1132. [MGI Ref ID J:26058]
Scriver CR; Tenenhouse HS. 1992. X-linked hypophosphataemia: a homologous phenotype in humans and mice with unusual organ-specific gene dosage. J Inherit Metab Dis 15(4):610-24. [PubMed: 1528020] [MGI Ref ID J:3136]
Shetty NS; Meyer RA Jr. 1991. Craniofacial abnormalities in mice with X-linked hypophosphatemic genes (Hyp or Gy). Teratology 44(4):463-72. [PubMed: 1962291] [MGI Ref ID J:1654]
Strom TM; Francis F; Lorenz B; Boddrich A; Econs MJ; Lehrach H ; Meitinger T. 1997. Pex gene deletions in Gy and Hyp mice provide mouse models for X-linked hypophosphatemia. Hum Mol Genet 6(2):165-71. [PubMed: 9063736] [MGI Ref ID J:38621]
Tenenhouse HS; Beck L. 1996. Renal Na(+)-phosphate cotransporter gene expression in X-linked Hyp and Gy mice. Kidney Int 49(4):1027-32. [PubMed: 8691720] [MGI Ref ID J:32872]
Tenenhouse HS; Meyer RA Jr; Mandla S; Meyer MH; Gray RW. 1992. Renal phosphate transport and vitamin D metabolism in X-linked hypophosphatemic Gy mice: responses to phosphate deprivation. Endocrinology 131(1):51-6. [PubMed: 1612032] [MGI Ref ID J:1824]
Thornton SW; Tenenhouse HS; Martel J; Bockian RW; Meyer MH; Meyer RA Jr. 1994. X-linked hypophosphatemic Gy mice: renal tubular maximum for phosphate vs. brush-border transport after low-P diet. Am J Physiol 266(2 Pt 2):F309-15. [PubMed: 8141332] [MGI Ref ID J:17268]
Wang X; Ikeguchi Y; McCloskey DE; Nelson P; Pegg AE. 2004. Spermine synthesis is required for normal viability, growth, and fertility in the mouse. J Biol Chem 279(49):51370-5. [PubMed: 15459188] [MGI Ref ID J:95185]
Wang X; Levic S; Gratton MA; Doyle KJ; Yamoah EN; Pegg AE. 2009. Spermine synthase deficiency leads to deafness and a profound sensitivity to alpha-difluoromethylornithine. J Biol Chem 284(2):930-7. [PubMed: 19001365] [MGI Ref ID J:145570]
Woodward JE; Meyer MH; Gray RW; Meyer RA Jr. 1993. Intestinal malabsorption of 45calcium in young Gy mice, a second model for X-linked hypophosphatemia. J Bone Miner Res 8(11):1281-90. [PubMed: 8266820] [MGI Ref ID J:17152]
Health & husbandry
Health & Colony Maintenance Information
Currently there no information available for this strain. This may be due to the supply level of this strain.
Purchasing information
Pricing, Supply Level & Notes, Controls, General Terms & Conditions
Pricing
| Pricing for USA, Canada and Mexico shipping destinations |
|
Animals Provided
Price (US dollars $) Cryorecovery Fee $1900.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Additional Supply Details
| Pricing for International shipping destinations |
|
Animals Provided
Price (US dollars $) Cryorecovery Fee $2470.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Additional Supply Details
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Supply Details
| Standard Supply | Cryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information. |
|---|---|
| Supply Notes |
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Control Information
| Control | ||
|---|---|---|
| Wild-type from the colony | ||
| Considerations for Choosing Controls | ||
| USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
| International - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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