Strain Name:

B6EiC3Sn a/A-Gy/J

Stock Number:

000503

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Availability:

Cryopreserved - Ready for recovery

Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Former Names B6EiC3Sn-a/A-PhexGy    (Changed: 15-DEC-04 )
Type Mutant Stock;
Additional information on Genetically Engineered and Mutant Mice.
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Specieslaboratory mouse
GenerationN47p
Generation Definitions

Appearance
black, circling
Related Genotype: a/a Gy/+

black, unaffected
Related Genotype: a/a +/+

agouti, circling
Related Genotype: A/? Gy/+

agouti, unaffected
Related Genotype: A/? +/+

Description
Gyro (Gy) is an X-linked dominant mutation that causes circling behavior and defects in phospate metabolism. It is allelic with the hypophosphatemia mutation (PhexHyp). Hemizygous males and heterozygous females are characterized by hypophosphatemia, rickets, circling behavior, and inner ear abnormalities. Affected males are also sterile.

Control Information

  Control
   Wild-type from the colony
 
  Considerations for Choosing Controls

Related Strains

Strains carrying   a allele
003879   B10;TFLe-a/a T tf/+ tf/J
001538   B6 x B6C3Sn a/A-T(1;9)27H/J
000916   B6 x B6C3Sn a/A-T(5;12)31H/J
000602   B6 x B6C3Sn a/A-T(8;16)17H/J
000618   B6 x FSB/GnEi a/a Ctslfs/J
000577   B6 x STOCK a Oca2p Hps5ru2 Ednrbs/J
000601   B6 x STOCK a/a T(7;18)50H/J
000592   B6 x STOCK T(2;4)13H a/J
000001   B6.C3 A/a Mgrn1md/J
000231   B6;C3Fe a/a-Csf1op/J
000785   B6;D2-a Ces1ce/EiJ
000604   B6C3 a/A-T(10;13)199H +/+ Lystbg-J/J or Lystbg-2J/J
001750   B6C3Fe a/a-Eif3cXs-J/J
002807   B6C3Fe a/a-Meox2fla/J
000506   B6C3Fe a/a-Qkqk-v/J
000224   B6C3Fe a/a-Scyl1mdf/J
003020   B6C3Fe a/a-Zdhhc21dep/J
001037   B6C3Fe a/a-Agtpbp1pcd/J
000221   B6C3Fe a/a-Alx4lst-J/J
002062   B6C3Fe a/a-Atp7aMo-8J/J
001756   B6C3Fe a/a-Cacng2stg/J
001815   B6C3Fe a/a-Col1a2oim/J
000209   B6C3Fe a/a-Dh/J
000211   B6C3Fe a/a-Dstdt-J/J
000210   B6C3Fe a/a-Edardl-J/J
000207   B6C3Fe a/a-Edaraddcr/J
000182   B6C3Fe a/a-Eef1a2wst/J
001278   B6C3Fe a/a-Glra1spd/J
000241   B6C3Fe a/a-Glrbspa/J
002875   B6C3Fe a/a-Hoxd13spdh/J
000304   B6C3Fe a/a-Krt71Ca Scn8amed-J/J
000226   B6C3Fe a/a-Largemyd/J
000636   B6C3Fe a/a-Lmx1adr-J/J
001280   B6C3Fe a/a-Lse/J
001573   B6C3Fe a/a-MitfMi/J
001035   B6C3Fe a/a-Napahyh/J
000181   B6C3Fe a/a-Otogtwt/J
000278   B6C3Fe a/a-Papss2bm Hps1ep Hps6ru/J
000205   B6C3Fe a/a-Papss2bm/J
002078   B6C3Fe a/a-Pcdh15av-2J/J
000246   B6C3Fe a/a-Pitpnavb/J
001430   B6C3Fe a/a-Ptch1mes/J
000235   B6C3Fe a/a-Relnrl/J
000237   B6C3Fe a/a-Rorasg/J
000290   B6C3Fe a/a-Sox10Dom/J
000230   B6C3Fe a/a-Tcirg1oc/J
003612   B6C3Fe a/a-Trak1hyrt/J
001512   B6C3Fe a/a-Ttnmdm/J
001607   B6C3Fe a/a-Unc5crcm/J
000005   B6C3Fe a/a-Wc/J
000243   B6C3Fe a/a-Wnt1sw/J
000248   B6C3Fe a/a-Xpl/J
000624   B6C3Fe a/a-anx/J
008044   B6C3Fe a/a-bpck/J
002018   B6C3Fe a/a-din/J
002339   B6C3Fe a/a-nma/J
000240   B6C3Fe a/a-soc/J
000063   B6C3Fe a/a-sy/J
001055   B6C3Fe a/a-tip/J
000245   B6C3Fe a/a-tn/J
000296   B6C3Fe-a/a Hoxa13Hd Mcoln3Va-J/J
000019   B6C3Fe-a/a-Itpr1opt/J
001022   B6C3FeF1/J a/a
006450   B6EiC3 a/A-Vss/GrsrJ
000971   B6EiC3 a/A-Och/J
000551   B6EiC3 a/A-Tbx15de-H/J
000557   B6EiC3-+ a/LnpUl A/J
001811   B6EiC3Sn a/A-Otcspf-ash/J
002343   B6EiC3Sn a/A-Otcspf/J
000391   B6EiC3Sn a/A-Pax6Sey-Dey/J
001924   B6EiC3Sn a/A-Ts(1716)65Dn/J
001923   B6EiC3Sn a/A-Ts(417)2Lws TimT(4;17)3Lws/J
000225   C3FeLe.B6 a/a-Ptpn6me/J
000198   C3FeLe.B6-a/J
000291   C3FeLe.Cg-a/a Hm KitlSl Krt71Ca-J/J
001886   C3HeB/FeJLe a/a-gnd/J
000584   C57BL/6J-+ T(1;2)5Ca/a +/J
000284   CWD/LeJ
000670   DBA/1J
000671   DBA/2J
001057   HPT/LeJ
000260   JGBF/LeJ
000265   MY/HuLeJ
000308   SSL/LeJ
000994   STOCK a Myo5ad Mregdsu/J
000064   STOCK a Tyrp1b Pmelsi/J
002238   STOCK a Tyrp1b shmy/J
001433   STOCK a skt/J
000579   STOCK a tp/J
000319   STOCK a us/J
002648   STOCK a/a Cln6nclf/J
000317   STOCK a/a Egfrwa2/J
000302   STOCK a/a MitfMi-wh +/+ Itpr1opt/J
000286   STOCK a/a Myo5ad fd/+ +/J
000206   STOCK a/a Tyrc-h/J
001432   STOCK a/a Tyrp1b sks/Tyrp1b +/J
000281   STOCK a/a ma Flgft/J
000312   STOCK stb + a/+ Fignfi a/J
000596   STOCK T(2;11)30H/+ x AEJ-a Gdf5bp-H/J or A/J-a Gdf5bp-J/J
000970   STOCK T(2;16)28H A/T(2;16)28H a/J
000590   STOCK T(2;4)1Sn a/J
000594   STOCK T(2;8)26H a/T(2;8)26H a Tyrp1+/Tyrp1b/J
000623   TR/DiEiJ
View Strains carrying   a     (103 strains)

Strains carrying other alleles of a
000251   AEJ.Cg-ae +/a Gdf5bp-H/J
000202   AEJ/Gn-bd/J
000199   AEJ/GnLeJ
000433   B10.C-H3c H13? A/(28NX)SnJ
000427   B10.CE-H13b Aw/(30NX)SnJ
000423   B10.KR-H13? A/SnJ
000420   B10.LP-H13b Aw/Sn
000477   B10.PA-Pldnpa H3e at/SnJ
000419   B10.UW-H3b we Pax1un at/SnJ
003879   B10;TFLe-a/a T tf/+ tf/J
001538   B6 x B6C3Sn a/A-T(1;9)27H/J
000916   B6 x B6C3Sn a/A-T(5;12)31H/J
000602   B6 x B6C3Sn a/A-T(8;16)17H/J
000593   B6 x B6CBCa Aw-J/A-Grid2Lc T(2;6)7Ca MitfMi-wh/J
000502   B6 x B6CBCa Aw-J/A-Myo5aflr Gnb5flr/J
000599   B6 x B6CBCa Aw-J/A-T(5;13)264Ca KitW-v/J
002083   B6 x B6EiC3 a/A-T(7;16)235Dn/J
000507   B6 x B6EiC3 a/A-Otcspf/J
003759   B6 x B6EiC3Sn a/A-T(10;16)232Dn/J
002071   B6 x B6EiC3Sn a/A-T(11;17)202Dn/J
002113   B6 x B6EiC3Sn a/A-T(11A2;16B3)238Dn/J
002068   B6 x B6EiC3Sn a/A-T(11B1;16B5)233Dn/J
002069   B6 x B6EiC3Sn a/A-T(14E4or5;16B5)225Dn/J
001926   B6 x B6EiC3Sn a/A-T(15;16)198Dn/J
001832   B6 x B6EiC3Sn a/A-T(15E;16B1)60Dn/J
003758   B6 x B6EiC3Sn a/A-T(16C3-4;17A2)65Dn/J
001833   B6 x B6EiC3Sn a/A-T(1C2;16C3)45Dn/J
001903   B6 x B6EiC3Sn a/A-T(6F;18C)57Dn/J
001535   B6 x B6EiC3Sn a/A-T(8A4;12D1)69Dn/J
001831   B6 x B6EiC3Sn a/A-T(8C3;16B5)164Dn/J
000618   B6 x FSB/GnEi a/a Ctslfs/J
000577   B6 x STOCK a Oca2p Hps5ru2 Ednrbs/J
000601   B6 x STOCK a/a T(7;18)50H/J
000592   B6 x STOCK T(2;4)13H a/J
002016   B6(Cg)-Aw-J EdaTa-6J Chr YB6-Sxr/EiJ
000552   B6-Aw-J-EdaTa-6J.Cg-Sxr
001730   B6-Aw-J-EdaTa-6J.Cg-Sxrb Hya-/J
000841   B6-Aw-J.CBy-EdaTa-By/J
001809   B6-Aw-J.Cg-EdaTa-6J +/+ ArTfm/J
000600   B6-Gpi1b x B6CBCa Aw-J/A-T(7;15)9H Gpi1a/J
000769   B6.C/(HZ18)By-at-44J/J
000001   B6.C3 A/a Mgrn1md/J
000203   B6.C3-Aiy/a/J
000017   B6.C3-Avy/J
001572   B6.C3-am-J/J
000628   B6.CE-A Amy1b Amy2a5b/J
000021   B6.Cg-Ay/J
100409   B6129PF1/J-Aw-J/Aw
000231   B6;C3Fe a/a-Csf1op/J
004200   B6;CBACa Aw-J/A-Npr2cn-2J/GrsrJ
000785   B6;D2-a Ces1ce/EiJ
000505   B6C3 Aw-J/A-Mutedmu/J
000604   B6C3 a/A-T(10;13)199H +/+ Lystbg-J/J or Lystbg-2J/J
001750   B6C3Fe a/a-Eif3cXs-J/J
002807   B6C3Fe a/a-Meox2fla/J
000506   B6C3Fe a/a-Qkqk-v/J
000224   B6C3Fe a/a-Scyl1mdf/J
003020   B6C3Fe a/a-Zdhhc21dep/J
001037   B6C3Fe a/a-Agtpbp1pcd/J
000221   B6C3Fe a/a-Alx4lst-J/J
002062   B6C3Fe a/a-Atp7aMo-8J/J
001756   B6C3Fe a/a-Cacng2stg/J
001815   B6C3Fe a/a-Col1a2oim/J
000209   B6C3Fe a/a-Dh/J
000211   B6C3Fe a/a-Dstdt-J/J
000210   B6C3Fe a/a-Edardl-J/J
000207   B6C3Fe a/a-Edaraddcr/J
000182   B6C3Fe a/a-Eef1a2wst/J
001278   B6C3Fe a/a-Glra1spd/J
000241   B6C3Fe a/a-Glrbspa/J
002875   B6C3Fe a/a-Hoxd13spdh/J
000304   B6C3Fe a/a-Krt71Ca Scn8amed-J/J
000226   B6C3Fe a/a-Largemyd/J
000636   B6C3Fe a/a-Lmx1adr-J/J
001280   B6C3Fe a/a-Lse/J
001573   B6C3Fe a/a-MitfMi/J
001035   B6C3Fe a/a-Napahyh/J
000181   B6C3Fe a/a-Otogtwt/J
000278   B6C3Fe a/a-Papss2bm Hps1ep Hps6ru/J
000205   B6C3Fe a/a-Papss2bm/J
002078   B6C3Fe a/a-Pcdh15av-2J/J
000246   B6C3Fe a/a-Pitpnavb/J
001430   B6C3Fe a/a-Ptch1mes/J
000235   B6C3Fe a/a-Relnrl/J
000237   B6C3Fe a/a-Rorasg/J
000290   B6C3Fe a/a-Sox10Dom/J
000230   B6C3Fe a/a-Tcirg1oc/J
003612   B6C3Fe a/a-Trak1hyrt/J
001512   B6C3Fe a/a-Ttnmdm/J
001607   B6C3Fe a/a-Unc5crcm/J
000005   B6C3Fe a/a-Wc/J
000243   B6C3Fe a/a-Wnt1sw/J
000248   B6C3Fe a/a-Xpl/J
000624   B6C3Fe a/a-anx/J
008044   B6C3Fe a/a-bpck/J
002018   B6C3Fe a/a-din/J
002339   B6C3Fe a/a-nma/J
000240   B6C3Fe a/a-soc/J
000063   B6C3Fe a/a-sy/J
001055   B6C3Fe a/a-tip/J
000245   B6C3Fe a/a-tn/J
000065   B6C3Fe a/a-we Pax1un at/J
000296   B6C3Fe-a/a Hoxa13Hd Mcoln3Va-J/J
000019   B6C3Fe-a/a-Itpr1opt/J
003301   B6C3FeF1 a/A-Eya1bor/J
001022   B6C3FeF1/J a/a
000314   B6CBACa Aw-J/A-EdaTa/J-XO
000501   B6CBACa Aw-J/A-Aifm1Hq/J
001046   B6CBACa Aw-J/A-Grid2Lc/J
000500   B6CBACa Aw-J/A-Gs/J
002703   B6CBACa Aw-J/A-Hydinhy3/J
000247   B6CBACa Aw-J/A-Kcnj6wv/J
000287   B6CBACa Aw-J/A-Plp1jp EdaTa/J
000515   B6CBACa Aw-J/A-SfnEr/J
000242   B6CBACa Aw-J/A-spc/J
000288   B6CBACa Aw-J/A-we a Mafbkr/J
001201   B6CBACaF1/J-Aw-J/A
001752   B6CBCa Aw-J/A-T(7;15)9H/J
006450   B6EiC3 a/A-Vss/GrsrJ
000971   B6EiC3 a/A-Och/J
000551   B6EiC3 a/A-Tbx15de-H/J
000557   B6EiC3-+ a/LnpUl A/J
000504   B6EiC3Sn a/A-Cacnb4lh/J
000553   B6EiC3Sn a/A-Egfrwa2 Wnt3avt/J
001811   B6EiC3Sn a/A-Otcspf-ash/J
002343   B6EiC3Sn a/A-Otcspf/J
000391   B6EiC3Sn a/A-Pax6Sey-Dey/J
001924   B6EiC3Sn a/A-Ts(1716)65Dn/J
001923   B6EiC3Sn a/A-Ts(417)2Lws TimT(4;17)3Lws/J
001875   B6EiC3SnF1/J
000200   C3FeB6 A/Aw-J-Ankank/J
000638   C3FeB6 A/Aw-J-Spnb4qv-J/J
001203   C3FeB6F1/J A/Aw-J
000225   C3FeLe.B6 a/a-Ptpn6me/J
000198   C3FeLe.B6-a/J
000291   C3FeLe.Cg-a/a Hm KitlSl Krt71Ca-J/J
001272   C3H/HeSnJ-Ahvy/J
000099   C3HeB/FeJ-Avy/J
001886   C3HeB/FeJLe a/a-gnd/J
000338   C57BL/6J Aw-J-EdaTa-6J/J
000584   C57BL/6J-+ T(1;2)5Ca/a +/J
000258   C57BL/6J-Ai/a/J
000774   C57BL/6J-Asy/a/J
000569   C57BL/6J-Aw-J-EdaTa +/+ ArTfm/J
000051   C57BL/6J-Aw-J/J
000055   C57BL/6J-at-33J/J
000070   C57BL/6J-atd/J
000284   CWD/LeJ
000670   DBA/1J
000671   DBA/2J
001057   HPT/LeJ
000260   JGBF/LeJ
002468   KK.Cg-Ay/J
000262   LS/LeJ
000283   LT.CAST-A/J
000265   MY/HuLeJ
000308   SSL/LeJ
001759   STOCK A Tyrc Sha/J
001427   STOCK Aw us/J
000994   STOCK a Myo5ad Mregdsu/J
000064   STOCK a Tyrp1b Pmelsi/J
002238   STOCK a Tyrp1b shmy/J
001433   STOCK a skt/J
000579   STOCK a tp/J
000319   STOCK a us/J
002648   STOCK a/a Cln6nclf/J
000317   STOCK a/a Egfrwa2/J
000302   STOCK a/a MitfMi-wh +/+ Itpr1opt/J
000286   STOCK a/a Myo5ad fd/+ +/J
000206   STOCK a/a Tyrc-h/J
001432   STOCK a/a Tyrp1b sks/Tyrp1b +/J
000281   STOCK a/a ma Flgft/J
000312   STOCK stb + a/+ Fignfi a/J
000596   STOCK T(2;11)30H/+ x AEJ-a Gdf5bp-H/J or A/J-a Gdf5bp-J/J
000970   STOCK T(2;16)28H A/T(2;16)28H a/J
000590   STOCK T(2;4)1Sn a/J
000594   STOCK T(2;8)26H a/T(2;8)26H a Tyrp1+/Tyrp1b/J
000623   TR/DiEiJ
View Strains carrying other alleles of a     (178 strains)

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

Gy/Gy+

        involves: C3H/Sn * C57BL/6Ei
  • growth/size phenotype
  • abnormal postnatal growth/weight/body size
    • all females have a squared trunk   (MGI Ref ID J:88352)
  • limbs/digits/tail phenotype
  • abnormal hindlimb morphology
    • shortened hind limbs are seen   (MGI Ref ID J:88352)
  • short tail   (MGI Ref ID J:88352)

Gy/Y

        involves: C3H/Sn * C57BL/6Ei
  • adipose tissue phenotype
  • decreased total body fat amount
    • a significant increase in lean body mass is seen compared to control   (MGI Ref ID J:88352)
  • growth/size phenotype
  • decreased body weight
    • all males have significantly lower body weights (~50% less than controls) and a squared trunk   (MGI Ref ID J:88352)
    • male Gy mutants weigh significantly less than other PhexHyp male mutants (PhexHyp, PhexHyp-2J, PhexHyp-Duk)   (MGI Ref ID J:88352)
  • hearing/vestibular/ear phenotype
  • decreased brainstem auditory evoked potential
    • mean auditory brainstem response thresholds are significantly higher than controls   (MGI Ref ID J:88352)
  • homeostasis/metabolism phenotype
  • decreased circulating potassium level
    • at 6 weeks of age serum PO4 levels are significantly lower than controls   (MGI Ref ID J:88352)
  • hypocalcemia
    • at 6 weeks of age serum Ca2+ are significantly decreased compared to controls   (MGI Ref ID J:88352)
  • limbs/digits/tail phenotype
  • abnormal hindlimb morphology
    • shortened hind limbs are seen   (MGI Ref ID J:88352)
  • abnormal limb bone morphology   (MGI Ref ID J:88352)
    • abnormal patella morphology
      • growth plates of the knee are thickened and irregular   (MGI Ref ID J:88352)
    • decreased length of long bones
      • the long bones are shortened   (MGI Ref ID J:88352)
      • short femur   (MGI Ref ID J:88352)
      • short fibula
        • the fibula is shortened and splayed   (MGI Ref ID J:88352)
      • short tibia
        • the tibia is shortened and splayed   (MGI Ref ID J:88352)
    • disorganized long bone epiphyseal plate
      • disorganized femoral growth plates   (MGI Ref ID J:88352)
    • increased diameter of long bones
      • the long bones are thickened   (MGI Ref ID J:88352)
  • short tail   (MGI Ref ID J:88352)
  • skeleton phenotype
  • abnormal limb bone morphology   (MGI Ref ID J:88352)
    • abnormal patella morphology
      • growth plates of the knee are thickened and irregular   (MGI Ref ID J:88352)
    • decreased length of long bones
      • the long bones are shortened   (MGI Ref ID J:88352)
      • short femur   (MGI Ref ID J:88352)
      • short fibula
        • the fibula is shortened and splayed   (MGI Ref ID J:88352)
      • short tibia
        • the tibia is shortened and splayed   (MGI Ref ID J:88352)
    • disorganized long bone epiphyseal plate
      • disorganized femoral growth plates   (MGI Ref ID J:88352)
    • increased diameter of long bones
      • the long bones are thickened   (MGI Ref ID J:88352)
  • decreased bone mineral density
    • between 6 and 40 weeks of age under-mineralized bone is present throughout the body   (MGI Ref ID J:88352)

The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.

Gy/Gy

        involves: 101/H * C3H/HeH * C3H/HeSnJ * C57BL/6J
  • homeostasis/metabolism phenotype
  • hypophosphatemia   (MGI Ref ID J:17152)
  • growth/size phenotype
  • decreased body weight   (MGI Ref ID J:17152)
  • digestive/alimentary phenotype
  • decreased intestinal calcium absorption
    • at 4 weeks, mice exhibit reduced calcium absorption in the duodenum compared with wild-type mice   (MGI Ref ID J:17152)

Gy/Gy+

        involves: 101/H * C3H/HeH
  • behavior/neurological phenotype
  • circling   (MGI Ref ID J:64263)
    • mild in some mice   (MGI Ref ID J:8335)
  • hearing/vestibular/ear phenotype
  • deafness   (MGI Ref ID J:64263)
  • growth/size phenotype
  • decreased body weight   (MGI Ref ID J:8335)
  • homeostasis/metabolism phenotype
  • hypophosphatemia   (MGI Ref ID J:8335)
  • limbs/digits/tail phenotype
  • short femur   (MGI Ref ID J:8335)
  • skeleton phenotype
  • short femur   (MGI Ref ID J:8335)

Gy/Y

        involves: 101/H * C3H/HeH
  • mortality/aging
  • premature death
    • sudden   (MGI Ref ID J:8335)
  • reproductive system phenotype
  • decreased testis weight   (MGI Ref ID J:8335)
  • male infertility   (MGI Ref ID J:8335)
  • oligozoospermia   (MGI Ref ID J:8335)
  • skeleton phenotype
  • abnormal long bone morphology
    • abnormal fibula morphology
      • uneven thickness   (MGI Ref ID J:8335)
    • decreased length of long bones   (MGI Ref ID J:8335)
    • increased diameter of long bones   (MGI Ref ID J:8335)
  • abnormal osteoid morphology
    • osteoid seams are widened compared to in wild-type mice   (MGI Ref ID J:8335)
  • abnormal rib morphology
    • uneven thickness   (MGI Ref ID J:8335)
    • splayed ribs   (MGI Ref ID J:8335)
  • osteomalacia   (MGI Ref ID J:8335)
  • hearing/vestibular/ear phenotype
  • abnormal ear morphology
    • mice exhibit abnormal vestibular sense organs compared with wild-type mice   (MGI Ref ID J:8335)
    • abnormal organ of Corti morphology   (MGI Ref ID J:8335)
      • cochlear hair cell degeneration   (MGI Ref ID J:8335)
    • abnormal semicircular canal morphology
      • stenotic   (MGI Ref ID J:8335)
    • detached tectorial membrane   (MGI Ref ID J:8335)
    • utricular degeneration   (MGI Ref ID J:8335)
    • vestibular saccular degeneration   (MGI Ref ID J:8335)
  • deafness   (MGI Ref ID J:64263)
  • behavior/neurological phenotype
  • absent pinna reflex   (MGI Ref ID J:8335)
  • circling   (MGI Ref ID J:64263)
  • head shaking   (MGI Ref ID J:8335)
  • hyperactivity   (MGI Ref ID J:8335)
  • impaired righting response
    • absent   (MGI Ref ID J:8335)
  • vision/eye phenotype
  • abnormal eyelid morphology   (MGI Ref ID J:8335)
    • blepharitis   (MGI Ref ID J:8335)
  • growth/size phenotype
  • decreased body size
    • at P1   (MGI Ref ID J:8335)
    • decreased body weight   (MGI Ref ID J:8335)
  • homeostasis/metabolism phenotype
  • abnormal urine nucleotide level
    • urinary cAMP is increased compared to in wild-type mice   (MGI Ref ID J:8335)
  • hypophosphatemia   (MGI Ref ID J:8335)
  • increased circulating alkaline phosphatase level   (MGI Ref ID J:8335)
  • increased urine phosphate level   (MGI Ref ID J:8335)
  • immune system phenotype
  • blepharitis   (MGI Ref ID J:8335)
  • nervous system phenotype
  • abnormal cochlear nerve morphology   (MGI Ref ID J:8335)
  • cochlear hair cell degeneration   (MGI Ref ID J:8335)
  • renal/urinary system phenotype
  • abnormal urine nucleotide level
    • urinary cAMP is increased compared to in wild-type mice   (MGI Ref ID J:8335)
  • increased urine phosphate level   (MGI Ref ID J:8335)
  • craniofacial phenotype
  • abnormal head morphology   (MGI Ref ID J:8335)
    • abnormal tooth morphology   (MGI Ref ID J:8335)
  • endocrine/exocrine gland phenotype
  • decreased testis weight   (MGI Ref ID J:8335)
  • limbs/digits/tail phenotype
  • abnormal long bone morphology
    • abnormal fibula morphology
      • uneven thickness   (MGI Ref ID J:8335)
    • decreased length of long bones   (MGI Ref ID J:8335)
    • increased diameter of long bones   (MGI Ref ID J:8335)

Gy/Y

        involves: 101/H * C3H/HeH * C57BL/6J
  • craniofacial phenotype
  • abnormal cranium morphology
    • mice exhibit smaller cranial length, neurocranial length, and length from anterior to posterior palatine foramen compared with wild-type mice   (MGI Ref ID J:1654)
    • abnormal cranial suture morphology
      • mice exhibit prominent bulges at the frontonasal suture and the premaxiallary-maxillary suture unlike in wild-type mice   (MGI Ref ID J:1654)
    • decreased cranium height   (MGI Ref ID J:1654)
    • domed cranium   (MGI Ref ID J:1654)
    • short frontal bone   (MGI Ref ID J:1654)
    • short mandible   (MGI Ref ID J:1654)
    • short nasal bone   (MGI Ref ID J:1654)
    • short premaxilla   (MGI Ref ID J:1654)
  • skeleton phenotype
  • abnormal cranium morphology
    • mice exhibit smaller cranial length, neurocranial length, and length from anterior to posterior palatine foramen compared with wild-type mice   (MGI Ref ID J:1654)
    • abnormal cranial suture morphology
      • mice exhibit prominent bulges at the frontonasal suture and the premaxiallary-maxillary suture unlike in wild-type mice   (MGI Ref ID J:1654)
    • decreased cranium height   (MGI Ref ID J:1654)
    • domed cranium   (MGI Ref ID J:1654)
    • short frontal bone   (MGI Ref ID J:1654)
    • short mandible   (MGI Ref ID J:1654)
    • short nasal bone   (MGI Ref ID J:1654)
    • short premaxilla   (MGI Ref ID J:1654)

Gy/Y

        B6.Cg-Gy
  • homeostasis/metabolism phenotype
  • abnormal calcium ion homeostasis
    • mice exhibit increased calcium tissue content compared with wild-type mice   (MGI Ref ID J:17152)
  • hypophosphatemia   (MGI Ref ID J:17152)
  • digestive/alimentary phenotype
  • decreased intestinal calcium absorption
    • at 4 weeks, mice exhibit reduced calcium absorption in the duodenum compared with wild-type mice   (MGI Ref ID J:17152)

Gy/Y

        involves: 101/H * C3H/HeH * C3H/HeSnJ * C57BL/6J
  • homeostasis/metabolism phenotype
  • abnormal calcium ion homeostasis
    • mice exhibit increased calcium tissue content compared with wild-type mice   (MGI Ref ID J:17152)
  • hypophosphatemia   (MGI Ref ID J:17152)
  • growth/size phenotype
  • decreased body weight   (MGI Ref ID J:17152)
  • digestive/alimentary phenotype
  • decreased intestinal calcium absorption
    • at 4 weeks, mice exhibit reduced calcium absorption in the duodenum compared with wild-type mice   (MGI Ref ID J:17152)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Gy related

Endocrine Deficiency Research
Bone/Bone Marrow Defects

Mouse/Human Gene Homologs
hypophosphatemic D-resistant rickets, X-linked

Neurobiology Research
Hearing Defects

Sensorineural Research
Hearing Defects

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Gy
Allele Name gyro
Allele Type Radiation induced
Common Name(s) PhexGy;
Strain of Origin(C3H/HeH x 101/H)F1
Gene Symbol and Name Gy, gyro deletion region
Chromosome X
Associated Marker Note Affected-Count: 2Af1-Gene: MGI:109490Af2-Gene: MGI:107489
Molecular Note The phenotype of the gyro mouse has been attributed to a deletion of ~160-190 kb, that includes the Sms gene as well as the first three exons and the promoter of the Phex gene. [MGI Ref ID J:38621] [MGI Ref ID J:46360] [MGI Ref ID J:47232]
 
Allele Symbol a
Allele Name nonagouti
Allele Type Spontaneous
Strain of Originold mutant of the mouse fancy
Gene Symbol and Name a, nonagouti
Chromosome 2
Gene Common Name(s) AGSW; AGTI; AGTIL; ASP; As; SHEP9; agouti; agouti signal protein; agouti suppressor;
Molecular Note Characterization of this allele shows an insertion of DNA comprised of a 5.5kb virus-like element, VL30, into the first intron of the agouti gene. The VL30 element itself contains an additional 5.5 kb sequence, flanked by 526 bp of direct repeats. The host integration site is the same as for at-2Gso and Aw-38J and includes a duplication of four nucleotides of host DNA and a deletion of 2 bp from the end of each repeat. Northern analysis of mRNA from skin of homozygotes shows a smaller agouti message and levels 8 fold lower than found in wild-type. [MGI Ref ID J:16984] [MGI Ref ID J:24934]

Genotyping

Genotyping Information


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Additional References

Lyon MF; Scriver CR; Baker LR; Tenenhouse HS; Kronick J; Mandla S. 1986. The Gy mutation: another cause of X-linked hypophosphatemia in mouse. Proc Natl Acad Sci U S A 83(13):4899-903. [PubMed: 3460077]  [MGI Ref ID J:8335]

Meyer RA Jr; Henley CM; Meyer MH; Morgan PL; McDonald AG; Mills C ; Price DK. 1998. Partial deletion of both the spermine synthase gene and the Pex gene in the X-linked hypophosphatemic, gyro (Gy) mouse. Genomics 48(3):289-95. [PubMed: 9545633]  [MGI Ref ID J:47232]

Strom TM; Francis F; Lorenz B; Boddrich A; Econs MJ; Lehrach H ; Meitinger T. 1997. Pex gene deletions in Gy and Hyp mice provide mouse models for X-linked hypophosphatemia. Hum Mol Genet 6(2):165-71. [PubMed: 9063736]  [MGI Ref ID J:38621]

Gy related

Beck L; Tenenhouse HS; Meyer RA; Meyer MH; Biber J; Murer H. 1996. Renal expression of Na+-phosphate cotransporter mRNA and protein: effect of the Gy mutation and low phosphate diet. Pflugers Arch 431(6):936-41. [PubMed: 8927512]  [MGI Ref ID J:33927]

Carter TC; Lyon MF; Phillips RJ. 1960. The genetic sensitivity to X-rays of mouse foetal gonads Genet Res 1:351-5.  [MGI Ref ID J:28887]

Collins JF; Ghishan FK. 1996. The molecular defect in the renal sodium-phosphate transporter expression pathway of Gyro (Gy) mice is distinct from that of hypophosphatemic (Hyp) mice. FASEB J 10(7):751-9. [PubMed: 8635692]  [MGI Ref ID J:33265]

Lopatin AN; Shantz LM; Mackintosh CA; Nichols CG; Pegg AE. 2000. Modulation of potassium channels in the hearts of transgenic and mutant mice with altered polyamine biosynthesis. J Mol Cell Cardiol 32(11):2007-24. [PubMed: 11040105]  [MGI Ref ID J:102674]

Lorenz B; Francis F; Gempel K; Boddrich A; Josten M; Schmahl W ; Schmidt J ; Lehrach H ; Meitinger T ; Strom TM. 1998. Spermine deficiency in Gy mice caused by deletion of the spermine synthase gene. Hum Mol Genet 7(3):541-7. [PubMed: 9467015]  [MGI Ref ID J:46360]

Lorenz-Depiereux B; Guido VE; Johnson KR; Zheng QY; Gagnon LH; Bauschatz JD; Davisson MT; Washburn LL; Donahue LR; Strom TM; Eicher EM. 2004. New intragenic deletions in the Phex gene clarify X-linked hypophosphatemia-related abnormalities in mice. Mamm Genome 15(3):151-61. [PubMed: 15029877]  [MGI Ref ID J:88352]

Lyon MF. 1960. Gy - gyro Mouse News Lett 22:30.  [MGI Ref ID J:64263]

Lyon MF; Jarvis SE. 1980. Relation of gyro and hypophosphataemia Mouse News Lett 62:49.  [MGI Ref ID J:13833]

Lyon MF; Scriver CR; Baker LR; Tenenhouse HS; Kronick J; Mandla S. 1986. The Gy mutation: another cause of X-linked hypophosphatemia in mouse. Proc Natl Acad Sci U S A 83(13):4899-903. [PubMed: 3460077]  [MGI Ref ID J:8335]

Mackintosh CA; Pegg AE. 2000. Effect of spermine synthase deficiency on polyamine biosynthesis and content in mice and embryonic fibroblasts, and the sensitivity of fibroblasts to 1,3-bis-(2-chloroethyl)-N-nitrosourea Biochem J 351 Pt 2:439-47. [PubMed: 11023830]  [MGI Ref ID J:65535]

Meyer RA Jr; Henley CM; Meyer MH; Morgan PL; McDonald AG; Mills C ; Price DK. 1998. Partial deletion of both the spermine synthase gene and the Pex gene in the X-linked hypophosphatemic, gyro (Gy) mouse. Genomics 48(3):289-95. [PubMed: 9545633]  [MGI Ref ID J:47232]

Meyer RA Jr; Meyer MH; Gray RW; Bruns ME. 1995. Femoral abnormalities and vitamin D metabolism in X-linked hypophosphatemic (Hyp and Gy) mice. J Orthop Res 13(1):30-40. [PubMed: 7853101]  [MGI Ref ID J:24017]

Meyer RA Jr; Meyer MH; Morgan PL. 1996. Effects of altered diet on serum levels of 1,25-dihydroxyvitamin D and parathyroid hormone in X-linked hypophosphatemic (Hyp and Gy) mice. Bone 18(1):23-8. [PubMed: 8717533]  [MGI Ref ID J:36180]

Meyer RA; Morgan PL; Meyer MH. 1994. Measurement of parathyroid hormone in the mouse: secondary hyperparathyroidism in the X-linked hypophosphatemic (Gyro, gy) mouse. Endocrine 2(12):1127-1132.  [MGI Ref ID J:26058]

Scriver CR; Tenenhouse HS. 1992. X-linked hypophosphataemia: a homologous phenotype in humans and mice with unusual organ-specific gene dosage. J Inherit Metab Dis 15(4):610-24. [PubMed: 1528020]  [MGI Ref ID J:3136]

Shetty NS; Meyer RA Jr. 1991. Craniofacial abnormalities in mice with X-linked hypophosphatemic genes (Hyp or Gy). Teratology 44(4):463-72. [PubMed: 1962291]  [MGI Ref ID J:1654]

Strom TM; Francis F; Lorenz B; Boddrich A; Econs MJ; Lehrach H ; Meitinger T. 1997. Pex gene deletions in Gy and Hyp mice provide mouse models for X-linked hypophosphatemia. Hum Mol Genet 6(2):165-71. [PubMed: 9063736]  [MGI Ref ID J:38621]

Tenenhouse HS; Beck L. 1996. Renal Na(+)-phosphate cotransporter gene expression in X-linked Hyp and Gy mice. Kidney Int 49(4):1027-32. [PubMed: 8691720]  [MGI Ref ID J:32872]

Tenenhouse HS; Meyer RA Jr; Mandla S; Meyer MH; Gray RW. 1992. Renal phosphate transport and vitamin D metabolism in X-linked hypophosphatemic Gy mice: responses to phosphate deprivation. Endocrinology 131(1):51-6. [PubMed: 1612032]  [MGI Ref ID J:1824]

Thornton SW; Tenenhouse HS; Martel J; Bockian RW; Meyer MH; Meyer RA Jr. 1994. X-linked hypophosphatemic Gy mice: renal tubular maximum for phosphate vs. brush-border transport after low-P diet. Am J Physiol 266(2 Pt 2):F309-15. [PubMed: 8141332]  [MGI Ref ID J:17268]

Wang X; Ikeguchi Y; McCloskey DE; Nelson P; Pegg AE. 2004. Spermine synthesis is required for normal viability, growth, and fertility in the mouse. J Biol Chem 279(49):51370-5. [PubMed: 15459188]  [MGI Ref ID J:95185]

Wang X; Levic S; Gratton MA; Doyle KJ; Yamoah EN; Pegg AE. 2009. Spermine synthase deficiency leads to deafness and a profound sensitivity to alpha-difluoromethylornithine. J Biol Chem 284(2):930-7. [PubMed: 19001365]  [MGI Ref ID J:145570]

Woodward JE; Meyer MH; Gray RW; Meyer RA Jr. 1993. Intestinal malabsorption of 45calcium in young Gy mice, a second model for X-linked hypophosphatemia. J Bone Miner Res 8(11):1281-90. [PubMed: 8266820]  [MGI Ref ID J:17152]

a related

Baba K; Sakakibara S; Setsu T; Terashima T. 2007. The superficial layers of the superior colliculus are cytoarchitectually and myeloarchitectually disorganized in the reelin-deficient mouse, reeler. Brain Res 1140:205-15. [PubMed: 17173877]  [MGI Ref ID J:120267]

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Russell ES. 1948. A Quantitative Histological Study of the Pigment Found in the Coat Color Mutants of the House Mouse. II. Estimates of the Total Volume of Pigment. Genetics 33(3):228-36. [PubMed: 17247280]  [MGI Ref ID J:148462]

Russell ES. 1946. A Quantitative Histological Study of the Pigment Found in the Coat-Color Mutants of the House Mouse. I. Variable Attributes of the Pigment Granules. Genetics 31(3):327-46. [PubMed: 17247200]  [MGI Ref ID J:148463]

Russell ES. 1949. A Quantitative Histological Study of the Pigment Found in the Coat-Color Mutants of the House Mouse. IV. the Nature of the Effects of Genic Substitution in Five Major Allelic Series. Genetics 34(2):146-66. [PubMed: 17247308]  [MGI Ref ID J:12958]

Russell LB. 1964. Genetic and Functional Mosaicism in the Mouse. In: The Role of the Chromosomes in Development. Academic Press, New York.  [MGI Ref ID J:29504]

Russell LB; Cupp McDaniel MN; Woodiel FN,. 1963. Crossing over within the a "locus" of the mouse Genetics 48:907 Abstr.  [MGI Ref ID J:174047]

SILVERS WK. 1958. An experimental approach to action of genes at the agouti locus in the mouse. III. Transplants of newborn Aw-, A-and at-skin to Ay-, Aw-, A-and aa hosts. J Exp Zool 137(1):189-96. [PubMed: 13563791]  [MGI Ref ID J:13013]

Sakurai T; Ochiai H; Takeuchi T. 1975. Ultrastructural change of melanosomes associated with agouti pattern formation in mouse hair. Dev Biol 47(2):466-71. [PubMed: 1204945]  [MGI Ref ID J:5606]

Silvers WK. 1979. The Coat Colors of Mice; A Model for Mammalian Gene Action and Interaction. In: The Coat Colors of Mice. Springer-Verlag, New York.  [MGI Ref ID J:78801]

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Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, RG10/RG30.

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Cryorecovery* $1980.00
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At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

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  • Cryorecovery - Standard.
    We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. The total number of animals provided, their gender and genotype will vary. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 13 and 16 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
    Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

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Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $2574.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information.

Supply Notes

  • Cryorecovery - Standard.
    We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. The total number of animals provided, their gender and genotype will vary. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 13 and 16 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
    Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

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Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information.

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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


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