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Former Names B6D2-Sox18Ra-op/J (Changed: 05-JUL-05 ) Type Mutant Strain; Spontaneous Mutation; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Species laboratory mouse Generation N77p Description
The Sox18Ra-Op allele causes a more severe phenotype than either the Sox18Ra or Sox18Ra-J allele. Green and Mann determined that only approximately 17% of the Sox18Ra-Op/+ heterozygotes are born and survive to wean age. Heterozygotes have a deficiency of vibrissae, a distinguishing feature in utero and usually evident at birth, and can be distinguished at three days of age by their pink skin which, with its delayed coat development, fails to darken like that of wildtype siblings. A paucity of fur is apparent by 9 days of age and persists throughout life. Heterozygotes are smaller in overall size and many of those that die shortly after birth are cyanotic and edematous. Dead pups have glossy skin with red patches that may result from superficial hemorrhages. Homozygotes die by embryonic day 11.5. (Green and Mann, 1961; Mann, 1963.)
Strains carrying other alleles of Sox18
000018 B6.Cg-Sox18Ra/J 000125 B6By.Cg-Sox18Ra Pt Os/J 002261 C3H/HeSnJ-Sox18Ra-J/J 000267 ROP/GnLeJ View Strains carrying other alleles of Sox18 (4 strains)
View Research Applications
Currently there is no phenotype information for this strain.Research Applications
This mouse can be used to support research in many areas including:Sox18Ra-Op related
Dermatology Research
Skin and Hair Texture Defects
| Allele Symbol | Sox18Ra-Op | ||
|---|---|---|---|
| Allele Name | opossum | ||
| Allele Type | Spontaneous | ||
| Common Name(s) | Op; RaOp; | ||
| Strain of Origin | (C57BL/6J x DBA/2J)F1 | ||
| Gene Symbol and Name | Sox18, SRY-box containing gene 18 | ||
| Chromosome | 2 | ||
| Gene Common Name(s) | AI385749; HLTS; Ra; Ragl; Sry-related HMG-box gene; expressed sequence AI385749; ragged; ragged-like; | ||
| General Note | Sox18ra-op, opossum, semidominant. Appeared spontaneously in a hybrid between the C57BL/6J and DBA/2J strains (J:260). Heterozygotes have very sparse fur consisting mostly of guard hairs and awls. The anterior vibrissae are absent. Viability is low, many heterozygotes dying shortly after birth in an edematous condition. Some develop a white fluid in the peritoneal cavity as in Sox18ra-op/+ and usually die before weaning. The surviving females are very poor breeders, but males may benormally fertile. Homozygotes die in utero, probably before 11 days. Sox18ra-op/ra-op mice also die in utero, probably before 11 days (J:279). Note: The Sox18 allele called ragged-oppossum was originally given a symbol, Op (J:260). It was found to be an allele of ragged in 1963 (J:279), and later found to be an allele of Sox18 (J:61488). The symbol, Op, was subsequenntly re-used for osteopetrosis (op). The symbol Chy (chylous ascites) described as a pleiotropic effect of Ra (J:13448) was withdrawn and later re-used for a gene on Chr 11 (J:14001). | ||
| Molecular Note | The mutation was identified as a deletion of a single cytosine at nucleotide 1048. [MGI Ref ID J:74211] | ||
This strain will not have a genotyping protocol or one is not currently available.
Helpful Links
Optimizing PCR Protocols
Dunn TL; Mynett-Johnson L; Wright EM; Hosking BM; Koopman PA; Muscat GE. 1995. Sequence and expression of Sox-18 encoding a new HMG-box transcription factor. Gene 161(2):223-5. [PubMed: 7665083] [MGI Ref ID J:28369]
Hosking BM; Wyeth JR; Pennisi DJ; Wang SC; Koopman P; Muscat GE. 2001. Cloning and functional analysis of the Sry-related HMG box gene, Sox18. Gene 262(1-2):239-47. [PubMed: 11179689] [MGI Ref ID J:67559]
James K; Hosking B; Gardner J; Muscat GE; Koopman P. 2003. Sox18 mutations in the ragged mouse alleles ragged-like and opossum. Genesis 36(1):1-6. [PubMed: 12748961] [MGI Ref ID J:83731]
Pennisi D; Bowles J; Nagy A; Muscat G; Koopman P. 2000. Mice null for sox18 are viable and display a mild coat defect Mol Cell Biol 20(24):9331-6. [PubMed: 11094083] [MGI Ref ID J:66010]
Pennisi D; Gardner J; Chambers D; Hosking B; Peters J; Muscat G; Abbott C; Koopman P. 2000. Mutations in Sox18 underlie cardiovascular and hair follicle defects in ragged mice. Nat Genet 24(4):434-7. [PubMed: 10742113] [MGI Ref ID J:61488]
Sox18Ra-Op relatedDownes M; Koopman P. 2001. SOX18 and the transcriptional regulation of blood vessel development. Trends Cardiovasc Med 11(8):318-24. [PubMed: 11728880] [MGI Ref ID J:74211]
Green EL; Mann SJ. 1961. Opossum, a semi-dominant lethal mutation affecting hair and other characteristics of mice J Hered 52:223-7. [MGI Ref ID J:260]
James K; Hosking B; Gardner J; Muscat GE; Koopman P. 2003. Sox18 mutations in the ragged mouse alleles ragged-like and opossum. Genesis 36(1):1-6. [PubMed: 12748961] [MGI Ref ID J:83731]
Mann SJ. 1963. The phenogenetics of hair mutants in the house mouse: Opossum and Ragged Genet Res 4:1-11. [MGI Ref ID J:279]
Pennisi D; Gardner J; Chambers D; Hosking B; Peters J; Muscat G; Abbott C; Koopman P. 2000. Mutations in Sox18 underlie cardiovascular and hair follicle defects in ragged mice. Nat Genet 24(4):434-7. [PubMed: 10742113] [MGI Ref ID J:61488]
Sundberg JP (ed.). 1994. . In: Handbook of Mouse Mutations with Skin and Hair Abnormalities: Animal Models and Biomedical Tools. CRC Press, Boca Raton. [MGI Ref ID J:30359]
Wallace ME. 1966. Chylous ascites pleiotropic effect of Ra. Mouse News Lett 35:16. [MGI Ref ID J:13448]
Young N; Hahn CN; Poh A; Dong C; Wilhelm D; Olsson J; Muscat GE; Parsons P; Gamble JR; Koopman P. 2006. Effect of disrupted SOX18 transcription factor function on tumor growth, vascularization, and endothelial development. J Natl Cancer Inst 98(15):1060-7. [PubMed: 16882943] [MGI Ref ID J:112009]
Currently there no information available for this strain. This may be due to the supply level of this strain.
| Pricing for USA, Canada and Mexico shipping destinations |
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Animals Provided
Price (US dollars $) Cryorecovery Fee $1900.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
| Pricing for International shipping destinations |
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Animals Provided
Price (US dollars $) Cryorecovery Fee $2470.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
| Standard Supply | Cryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information. |
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| Supply Notes |
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