Strain Name: |
C3H/HeJ-Oca2p-J/J |
|---|---|
Stock Number: |
000513 |
Availability: | Repository-Cryopreserved |
General Terms and Conditions |
| Former Name |
C3H/HeJ-pJ/J (Changed: 11-FEB-08
) |
| Genes & Alleles | Oca2; Oca2p-J; |
Product Information
Strain Details
Type JAX® GEMM® Strain - Coisogenic Additional information on JAX® GEMM® Strains. Type JAX® GEMM® Strain - Mutant Strain Type JAX® GEMM® Strain - Spontaneous Mutation Species laboratory mouse Generation F65+102pN1 Appearance
agouti
Related Genotype: A/A +/Oca2p-J
pink-eyed, blond coat color
Related Genotype: A/A Oca2p-J/Oca2p-JStrain Description
Oca2p-J/Oca2p-J mice exhibit significant dilution of coat color with pink eyes, a phenotype similar to that produced by Oca2p/Oca2p. The Oca2p-J mutation is a partial deletion of the gene that completely ablates Oca2p function (Oakey et al. 1996).Strain Development
The Oca2p-J mutation occurred spontaneously in the C3H/HeJ strain at The Jackson Laboratory in 1974.
Gene & Allele Details
| Allele Symbol | Oca2p-J | ||
|---|---|---|---|
| Allele Name | pink-eyed dilution Jackson | ||
| Common Name(s) | pJ; | ||
| Strain of Origin | C3H/HeJ | ||
| Gene Symbol and Name | Oca2, oculocutaneous albinism II | ||
| Chromosome | 7 | ||
| Gene Common Name(s) | BEY; BEY1; BEY2; BOCA; D15S12; D7H15S12; D7Icr28RN; D7Nic1; DNA segment, Chr 7, Institute for Cancer Research 28RN; DNA segment, Chr 7, Nicholls 1; DNA segment, Chr 7, human D15S12; EYCL; EYCL2; EYCL3; HCL3; P; PED; SHEP1; p; pink-eyed dilution; | ||
| General Note | pJ, pink-eyed dilution-Jackson, recessive. This mutation arose spontaneously in C3H/HeJ in 1974. It produces a phenotype similar to that of p and was shown by breeding tests to be an allele at the p locus, presumably a remutation. Both femalesand males are fertile (J:2108). At least twelve other remutations to p have arisen at The Jackson Laboratory (Sweet, H.O., 1992, personal communication). | ||
Control Information
| Allele | Control | |
|---|---|---|
| Oca2p-J | Heterozygote from the colony | |
| 000659 C3H/HeJ | ||
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying Oca2p-J allele
002460 C3H/HeJ-Oca2p-J Is(7;1)40H/J 001584 STOCK Oca2p-J/Oca2p-bs/J View Strains carrying Oca2p-J (2 strains)
000090 129S1/Sv-Oca2+ Tyr+ KitlSl-J/J 000091 129T1/Sv-Oca2+ Tyrc-ch Dnd1Ter/J 001279 129T1/Sv-Oca2+ Tyrc-ch-Aft/J 000004 ABP/LeJ 000822 B6 x 129S1/SvEi Oca2+ Tyr+-Vsx2or-J/J 000577 B6 x STOCK a Oca2p Hps5ru2 Ednrbs/J 001059 B6By.Cg-Oca2p/J 001136 C57BL/6J-Oca2p-un+2J/J 001506 C57BL/6J-Oca2p-un+3J/J 001810 C57BL/6J-Oca2p-un+4J/J 001513 C57BL/6J-Oca2p-un+5J/J 001499 C57BL/6J-Oca2p-un+6J/J 001033 C57BL/6J-Oca2p-un+J/J 000028 C57BL/6J-Oca2p-un/J 000619 FS/EiJ 000494 J.Cg-Oca2+ Tyr+ Lystbg/J 000306 STOCK Dll3pu + Tyrc-ch/+ Oca2p Tyrc-ch/J 001584 STOCK Oca2p-J/Oca2p-bs/J 001585 STOCK Oca2p-d/Oca2p-25H/J 000823 STOCK Oca2p-d/Oca2p-6H/J 001747 STOCK Oca2p-d/Oca2p-cp/J 001618 STOCK Oca2p/Oca2p Prop1df/J
Research Applications
This mouse can be used to support research in many areas including:Oca2p-J related
Dermatology Research
Color and White Spotting Defects
Mouse/Human Gene Homologs
albinism, oculocutaneous type II, OCA2
References
Additional ReferencesPrice and Supply Information
| Strain Name: | C3H/HeJ-Oca2p-J/J |
| Stock Number: | 000513 |
Price Details
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Supply Details
| Standard Supply | Repository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information. |
|---|---|
| Supply Notes |
Cryorecovery - Standard. The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two males and two females (two pairs) will be provided, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the delivery time to approximately 25 weeks. At least one member of each pair will be of known genotype and will carry the mutation if it is a mutant strain. Please note that pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Price represents a repository maintenance fee, which includes the cost of recovery of the strain from the cryopreservation resource and the periodic replacement of the frozen embryos used for recovery. Cryorecovery to establish a Dedicated Supply for greater quantities of mice. |
| Licensing | See General Terms and Conditions below |
| Control Information | View Control Information in Strain Details. |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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