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Description
The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.
Strain Information
Former Names B6CBACa Aw-J/A-Er/J (Changed: 30-NOV-05 ) Type Mutant Strain; Spontaneous Mutation; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Species laboratory mouse Generation N3F1N1
Generation DefinitionsDescription
This mutation shows complete penetrance in heterozygotes. These mice grow a normal appearing but probably somewhat dry first coat until the age of about 13 days; then hair loss begins and continues until the fur becomes sparse. Repeated growth and re-epilation follow without a definite pattern. Heterozygotes are slightly reduced in size and some may die before weaning, but adults are fully viable and fertile. Homozygotes die at birth from inability to breathe because of a closed oral cavity. At embryonic day 17 the skin of homozygotes is extremely thin and smooth with few vibrissae and hair follicles. The snout is truncated and the mouth closed. The limbs and tail are greatly shortened and held close to the trunk and the anal and urogenital orifices are closed. There are marked skeletal abnormalities and cleft palate. Homozygotes can be recognized at 13 days of gestation by their blunt limbs and stumpy tail. Between 13 and 15 days the nares and oral opening close, resulting in marked compression and abnormality of the structures in the area. Heterozygotes are recognizable at 18 days of gestation by edema of the feet and hemorrhagic tail tip. Histologically, at 19 days of gestation, skin of heterozygotes does not differ from +/+ skin. Skin of homozygotes is characterized by wide intercellular spaces and highly variable numbers and distribution of cells of the spinous, granular, and superficial layers. A 26.5 kDa protein, filaggrin, is absent, but filaggrin precursors appear to be present. In heterozygotes there is a high incidence of multiple cutaneous papillomas and squamous cell carcinomas.Development
The repeated epilation mutation arose in a random bred stock at Oak Ridge National Laboratory in approximately 1960 and was subsequently imported into The Jackson Laboratory for Dr. George Snell. Dr. Snell passed this mutation to Dr. Don Bailey who maintained this dominant mutation by continuous backcrossing to C57BL/6By. Dr. Bailey later transferred this congenic strain to Dr. Eva Eicher and in 1983 the breeding scheme changed to crossing a heterozygote to a (C57BL/6J-Aw-J/J x CBA/CaGnLeJ)F1 hybrid at each generation. In 1984 embryos were generated for cryopreservation from C57BL/6J females bred with B6CBACa Aw-J/A-SfnEr/J heterozygous males at generation N3F1.
Related Strains
Facebase: models
View Facebase: models (58 strains)
Phenotype
Phenotype Information
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested. Skin/Hair/Eye Pigmentation, Variation In, 9; SHEP9 (ASIP)
assigned by genotype
SfnEr/Sfn+
B6CBACa Aw-J/A-SfnEr/J
- integument phenotype
- premature hair loss
- repeated hair loss in adults (MGI Ref ID J:102931)
SfnEr/SfnEr
B6CBACa Aw-J/A-SfnEr/J
- mortality/aging
- complete perinatal lethality
- die at birth due to respiratory stress (MGI Ref ID J:102931)
- respiratory system phenotype
- respiratory distress (MGI Ref ID J:102931)
- craniofacial phenotype
- abnormal craniofacial development
- fusion of the epithelium of the oral cavity (MGI Ref ID J:102931)
- limbs/digits/tail phenotype
- short limbs
- stumpy legs (MGI Ref ID J:102931)
- short tail
- stumpy tail (MGI Ref ID J:102931)
- integument phenotype
- abnormal keratinocyte differentiation
- failure of keratinocyte terminal differentiation; epidermis cells do not differentiate into mature granular and cornified cells (MGI Ref ID J:102931)
- absent epidermis stratum corneum
- the thickened epidermis lacks the stratum corneum (MGI Ref ID J:102931)
- absent epidermis stratum granulosum
- the thickened epidermis lacks the stratum granulosum (MGI Ref ID J:102931)
- epidermal hyperplasia (MGI Ref ID J:102931)
- shiny skin (MGI Ref ID J:102931)
- thick epidermis (MGI Ref ID J:102931)
- cellular phenotype
- abnormal keratinocyte differentiation
- failure of keratinocyte terminal differentiation; epidermis cells do not differentiate into mature granular and cornified cells (MGI Ref ID J:102931)
The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.
SfnEr/Sfn+
involves: 129/Sv * C57BL/6
- mortality/aging
- partial lethality at weaning
- growth/size phenotype
- postnatal growth retardation
- starting about the same time as hair loss (MGI Ref ID J:6200)
- tumorigenesis
- skin papilloma
- squamous cell carcinoma
- integument phenotype
- premature hair loss
- skin papilloma
- sparse hair (MGI Ref ID J:29020)
SfnEr/SfnEr
involves: 129/Sv * C57BL/6
- mortality/aging
- complete neonatal lethality
- respiratory system phenotype
- abnormal nose morphology
- oral cavity closed (MGI Ref ID J:6200)
- abnormal external nares morphology
- abnormal nasal cavity morphology
- the nasal cavities remain separated from the oral cavity and the palatal swellings are joined directly to the sidewalls of the nasal septum (MGI Ref ID J:7243)
- abnormal pharynx morphology
- at embryonic day 14 the nasal palatal zone is reduced in size, there is a palato-mandibular joining, and the areas bordering the oral cavity are compressed and deformed (MGI Ref ID J:7243)
- abnormal nasopharynx morphology
- by embryonic day 14 the naso-pharyngeal duct is greatly modified (MGI Ref ID J:7243)
- respiratory distress
- acute respiratory distress is cause of death (MGI Ref ID J:6200)
- respiratory failure
- pups try to breath but cannot due to closed oral cavity (MGI Ref ID J:6200)
- digestive/alimentary phenotype
- abnormal perineum morphology
- urogenital orifices undetectable (MGI Ref ID J:6200)
- abnormal tongue morphology
- inadequate space in the oral cavity for the tongue to develop abnormally such that at embryonic day 15 the apical extremity of the tongue is very far back, it is closely joined to the nasal septum for a long way, the dorsal surface is ondulated, its musculature is compressed in an antero-posterior direction and the tongue is compressed by the maxillae, palatal shelves and nasal septum (MGI Ref ID J:7243)
- at embryonic day 18 large lacunae are found in the lateral parts and cystic formation appear at the place of genio-glossal and genio-hyoid muscles (MGI Ref ID J:7243)
- tongue fused to both premaxilla and mandible (MGI Ref ID J:6200)
- anal atresia
- anal orifice undetectable (MGI Ref ID J:6200)
- cleft secondary palate
- palatal shelves fail to fuse along midline (MGI Ref ID J:6200)
- palatal shelf fusion with tongue or mandible
- development of the palatal shelves is impinged and they are connected to the tongue and mandible at embryonic days 14 and 15 such that they do not reorient (MGI Ref ID J:7243)
- herniated intestine
- 1-2 external loops of the bowel occasionally seen (Celosomia) (MGI Ref ID J:6200)
- liver/biliary system phenotype
- abnormal liver morphology
- sometimes partially protrudes from the body cavity (MGI Ref ID J:6200)
- craniofacial phenotype
- abnormal head morphology (MGI Ref ID J:7243)
- abnormal external auditory canal morphology
- the auditory ducts appear sealed at embryonic day 15 (MGI Ref ID J:7243)
- abnormal facial morphology
- beginning at embryonic day 13 the face, from the top of the cranium to the tip of the snout becomes flattened leaving a shortened snout and decreased prominance of the features, with vibrissae more difficult to discern (MGI Ref ID J:7243)
- abnormal nose morphology
- oral cavity closed (MGI Ref ID J:6200)
- abnormal external nares morphology
- abnormal nasal cavity morphology
- the nasal cavities remain separated from the oral cavity and the palatal swellings are joined directly to the sidewalls of the nasal septum (MGI Ref ID J:7243)
- abnormal orofacial morphology (MGI Ref ID J:6200)
- abnormal tongue morphology
- inadequate space in the oral cavity for the tongue to develop abnormally such that at embryonic day 15 the apical extremity of the tongue is very far back, it is closely joined to the nasal septum for a long way, the dorsal surface is ondulated, its musculature is compressed in an antero-posterior direction and the tongue is compressed by the maxillae, palatal shelves and nasal septum (MGI Ref ID J:7243)
- at embryonic day 18 large lacunae are found in the lateral parts and cystic formation appear at the place of genio-glossal and genio-hyoid muscles (MGI Ref ID J:7243)
- tongue fused to both premaxilla and mandible (MGI Ref ID J:6200)
- cleft secondary palate
- palatal shelves fail to fuse along midline (MGI Ref ID J:6200)
- palatal shelf fusion with tongue or mandible
- development of the palatal shelves is impinged and they are connected to the tongue and mandible at embryonic days 14 and 15 such that they do not reorient (MGI Ref ID J:7243)
- fused lips
- lip fusion begins laterally on embryonic day 13 and closure of the lips is nearly complete by embryonic day 15 (MGI Ref ID J:7243)
- oral atresia (MGI Ref ID J:6200)
- thin lip (MGI Ref ID J:6200)
- flattened snout (MGI Ref ID J:7243)
- short snout
- truncated (MGI Ref ID J:6200)
- microcephaly
- from embryonic day 13 on there is a clear reduction in the cephalic volume (MGI Ref ID J:7243)
- small ears
- abnormal jaw morphology
- abnormal mandible morphology
- by embryonic day 14 the mandible is malformed and fused with the maxilla leaving the oral cavity completely filled in (MGI Ref ID J:7243)
- limbs/digits/tail phenotype
- abnormal phalanx morphology
- brachyphalangia (MGI Ref ID J:6200)
- abnormal radius morphology
- radius held closer to humerus (MGI Ref ID J:6200)
- decreased caudal vertebrae number
- 10-12 caudal vertebrae missing (MGI Ref ID J:6200)
- short limbs
- limbs and tail greatly shortened (MGI Ref ID J:6200)
- skeleton phenotype
- abnormal axial skeleton morphology (MGI Ref ID J:6200)
- abnormal jaw morphology
- abnormal mandible morphology
- by embryonic day 14 the mandible is malformed and fused with the maxilla leaving the oral cavity completely filled in (MGI Ref ID J:7243)
- abnormal spine curvature
- by embryonic day 15 there is no curvature of the neck (MGI Ref ID J:7243)
- kyphosis
- accentuated dorsal curvature and head shifted slightly forward along body axis (MGI Ref ID J:6200)
- decreased caudal vertebrae number
- 10-12 caudal vertebrae missing (MGI Ref ID J:6200)
- abnormal phalanx morphology
- brachyphalangia (MGI Ref ID J:6200)
- abnormal radius morphology
- radius held closer to humerus (MGI Ref ID J:6200)
- reproductive system phenotype
- abnormal perineum morphology
- urogenital orifices undetectable (MGI Ref ID J:6200)
- hearing/vestibular/ear phenotype
- abnormal external auditory canal morphology
- the auditory ducts appear sealed at embryonic day 15 (MGI Ref ID J:7243)
- small ears
- vision/eye phenotype
- microphthalmia (MGI Ref ID J:6200)
- at embryonic day 13 the eyes are less prominant than normal and at embryonic day 15 the eyes are smaller and much less prominent than normal (MGI Ref ID J:7243)
- integument phenotype
- abnormal epidermal layer morphology (MGI Ref ID J:6708)
- abnormal epidermis stratum basale morphology
- abnormal epidermis stratum corneum morphology
- abnormal epidermis stratum granulosum morphology
- decreased hair follicle number
- hair follicles very rare (MGI Ref ID J:6200)
- shiny skin (MGI Ref ID J:6200)
- thin skin
SfnEr/SfnEr
involves: C57BL/6By
- limbs/digits/tail phenotype
- abnormal limb development
- the forelimbs are found to fuse with the flank skin and the himdlimbs are found to fuse with the tail epidermis (MGI Ref ID J:148459)
- abnormal foot plate morphology
- at embryonic day 13 the precartilaginous condensations of the distal footplate appear closer to each other than normal, on embryonic day 14 the footplate is severely deformed, being rounded with converging precartilaginous elements instead of flattened with radiating digit precartilages, and individualization of the digits does not occur (MGI Ref ID J:148459)
- abnormal limb bud morphology
- the limb bud is smaller than normal, does not flatten or form digits, and remains stumpy throughout development; the difference is detectable as early as embryonic day 13 (MGI Ref ID J:148459)
- abnormal tail morphology
- at embryonic day 13 the tail tip is bent toward the dorsal side, at embryonic day 14 there is a twisting or kinking of the distal part of the tail, and the tail is stumpy and joined to the hindlimbs from embryonic day 15 on (MGI Ref ID J:148459)
- syndactyly (MGI Ref ID J:148459)
- craniofacial phenotype
- abnormal craniofacial development (MGI Ref ID J:148459)
- abnormal lip morphology
- at embryonic day 15 the lips are fused (MGI Ref ID J:148459)
- vision/eye phenotype
- abnormal eyelid morphology
- at embryonic day 15 the lower eyelid covers much more of the cornea than it does in wild-type controls, only a small central area remains where the two eyelids have not grown together, the leading edge is irregular, abnormal, flattened ectodermal cells cover the entire surface of the cornea, and no corneal epithelium is visible (MGI Ref ID J:148460)
- by embryonic day 19 the eyelids are grown together and the surface covering the eye is smooth, thin, shiny and translucent (MGI Ref ID J:148460)
- in newborns a continuous sheet of epithelial cells, which are abnormally flat, densely packed, lacking distinct cell boundaries, and disorganized in their arrangement, extends from the anterior corneal stroma to the surface of the eyelid and compresses the eyelid stroma into a thin wedge (MGI Ref ID J:148460)
- microphthalmia
- evident at embryonic day 15 (MGI Ref ID J:148459)
- embryogenesis phenotype
- abnormal limb bud morphology
- the limb bud is smaller than normal, does not flatten or form digits, and remains stumpy throughout development; the difference is detectable as early as embryonic day 13 (MGI Ref ID J:148459)
- integument phenotype
- abnormal epidermal layer morphology
- at embryonic day 14 the flank epidermis is composed of several layers of flat cells and is approximately twice as thick as normal, while the dorsal and head skin remains thin (MGI Ref ID J:148459)
- at embryonic day 15 thickened epidermis extends to include the dorsal region and the hair nodules are delayed in appearance (MGI Ref ID J:148459)
- at embryonic day 16 the spinous layers are irregularly thickened and there are several layers of flattened cells above them (MGI Ref ID J:148459)
- while normal epidermis becomes wrinkled from embryonic day 17 onward, the epidermis of the homozygote remains smooth (MGI Ref ID J:148459)
- normal stratification of the epidermal layers is disturbed and on embyronic day 18 the basal layer has numerous lobes penetrating into the dermis, the hair follicles are irregularly spread between these lobes, the stratum spinosum is thickened with the superficial horny layers of the skin lacking or reduced, and the stratum granulosum is delayed in formation and varies in thickness (MGI Ref ID J:148459)
- distorted hair follicle pattern
- scarce hair follicles at the surface of the skin at embryonic day 18, but hair follicles are found irregularly distributed and localized deeper into the dermis than normal (MGI Ref ID J:148459)
SfnEr/SfnEr
Background Not Specified
- craniofacial phenotype
- *normal* craniofacial phenotype
- mice exhibit normal molar tooth germ (MGI Ref ID J:184926)
This mouse can be used to support research in many areas including:SfnEr related
Dermatology Research
Skin and Hair Texture Defects
Developmental Biology Research
Craniofacial and Palate Defects
congenital cleft palate
Perinatal Lethality
Homozygous
Skeletal Defects
Genes & Alleles
Gene & Allele Information provided by MGI
| Allele Symbol | Aw-J | ||
|---|---|---|---|
| Allele Name | white bellied agouti Jackson | ||
| Allele Type | Spontaneous | ||
| Common Name(s) | AWJ; | ||
| Strain of Origin | C57BL/6J | ||
| Gene Symbol and Name | a, nonagouti | ||
| Chromosome | 2 | ||
| Gene Common Name(s) | AGSW; AGTI; AGTIL; ASP; As; SHEP9; agouti; agouti signal protein; agouti suppressor; | ||
| Allele Symbol | SfnEr | ||
| Allele Name | repeated epilation | ||
| Allele Type | Radiation induced | ||
| Common Name(s) | Er; | ||
| Gene Symbol and Name | Sfn, stratifin | ||
| Chromosome | 4 | ||
| Gene Common Name(s) | 14-3-3 sigma; Er; MME1; YWHAS; Ywhas; repeated epilation; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, sigma polypeptide; | ||
| General Note | Sfn is on Chr 4 close to pupoid fetus (pf), a mutant which SfnEr closely resembles. | ||
| Molecular Note | A single T insertion at base pair 622 causes a frame shift mutation at amino acid residue 207 truncating the C-terminus of the protein. This eliminates residues required for ligand interaction. Production of truncated protein was demonstrated immunologically. The hair-loss phenotype could be rescued using a Sfn containing transgene. [MGI Ref ID J:101891] | ||
References
References provided by MGI
Additional References
Aw-J relatedSfnEr relatedAberg T; Wang XP; Kim JH; Yamashiro T; Bei M; Rice R; Ryoo HM; Thesleff I. 2004. Runx2 mediates FGF signaling from epithelium to mesenchyme during tooth morphogenesis. Dev Biol 270(1):76-93. [PubMed: 15136142] [MGI Ref ID J:92174]
Banerjee H; Das A; Srivastava S; Mattoo HR; Thyagarajan K; Khalsa JK; Tanwar S; Das DS; Majumdar SS; George A; Bal V; Durdik JM; Rath S. 2012. A role for apoptosis-inducing factor in T cell development. J Exp Med 209(9):1641-53. [PubMed: 22869892] [MGI Ref ID J:191446]
Barsh GS; Epstein CJ. 1989. Physical and genetic characterization of a 75-kilobase deletion associated with al, a recessive lethal allele at the mouse agouti locus. Genetics 121(4):811-8. [PubMed: 2566558] [MGI Ref ID J:9799]
Baurle J; Vogten H; Grusser-Cornehls U. 1998. Course and targets of the calbindin D-28k subpopulation of primary vestibular afferents. J Comp Neurol 402(1):111-28. [PubMed: 9831049] [MGI Ref ID J:118430]
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Mullen RJ. 1974. A<w-J> - white-bellied agouti-J Mouse News Lett 50:38. [MGI Ref ID J:64104]
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Poole TW. 1975. Dermal-epidermal interactions and the action of alleles at the agouti locus in the mouse. Dev Biol 42(2):203-10. [PubMed: 1090472] [MGI Ref ID J:5519]
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Prtenjaca A; Hill KA. 2011. Mutation frequency is not elevated in the cerebellum of harlequin/Big Blue((R)) mice but Class II deletions occur preferentially in young harlequin cerebellum. Mutat Res 707(1-2):53-60. [PubMed: 21195094] [MGI Ref ID J:168461]
Smith DE; Xu SG. 2003. Ultrastructural organization of GABA-like immunoreactive profiles in the weaver substantia nigra. J Neurocytol 32(3):293-303. [PubMed: 14724391] [MGI Ref ID J:121345]
Vandenput L; Swinnen JV; Boonen S; Van Herck E; Erben RG; Bouillon R; Vanderschueren D. 2004. Role of the androgen receptor in skeletal homeostasis: the androgen-resistant testicular feminized male mouse model. J Bone Miner Res 19(9):1462-70. [PubMed: 15312246] [MGI Ref ID J:111491]
Wu Q; Miller RH; Ransohoff RM; Robinson S; Bu J; Nishiyama A. 2000. Elevated levels of the chemokine GRO-1 correlate with elevated oligodendrocyte progenitor proliferation in the jimpy mutant. J Neurosci 20(7):2609-17. [PubMed: 10729341] [MGI Ref ID J:109469]
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Yoshida T; Katoh A; Ohtsuki G; Mishina M; Hirano T. 2004. Oscillating Purkinje neuron activity causing involuntary eye movement in a mutant mouse deficient in the glutamate receptor delta2 subunit. J Neurosci 24(10):2440-8. [PubMed: 15014119] [MGI Ref ID J:97010]
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van Empel VP; Bertrand AT; van der Nagel R; Kostin S; Doevendans PA; Crijns HJ; de Wit E; Sluiter W; Ackerman SL; De Windt LJ. 2005. Downregulation of apoptosis-inducing factor in harlequin mutant mice sensitizes the myocardium to oxidative stress-related cell death and pressure overload-induced decompensation. Circ Res 96(12):e92-e101. [PubMed: 15933268] [MGI Ref ID J:110278]
Blackburn J; Ohazama A; Kawasaki K; Otsuka-Tanaka Y; Liu B; Honda K; Rountree RB; Hu Y; Kawasaki M; Birchmeier W; Schmidt-Ullrich R; Kinoshita A; Schutte BC; Hammond NL; Dixon MJ; Sharpe PT. 2012. The role of Irf6 in tooth epithelial invagination. Dev Biol 365(1):61-70. [PubMed: 22366192] [MGI Ref ID J:184926]
Cousins S; Rodrigues MM; Brown KS; Dale BA. 1984. Abnormal corneal and eyelid development in the repeated epilation mouse. Lab Anim Sci 34(2):156-63. [PubMed: 6374282] [MGI Ref ID J:148460]
Fisher C. 1987. Abnormal development in the skin of the pupoid fetus (pf/pf) mutant mouse: abnormal keratinization, recovery of a normal phenotype, and relationship to the repeated epilation (Er/Er) mutant mouse. Curr Top Dev Biol 22:209-34. [PubMed: 2443312] [MGI Ref ID J:8835]
Fisher C. 2000. IKKalpha-/- mice share phenotype with pupoid fetus (pf/pf) and repeated epilation (Er/Er) mutant mice. Trends Genet 16(11):482-4. [PubMed: 11203384] [MGI Ref ID J:65526]
Fisher C; Byers MR; Iadarola MJ; Powers EA. 1991. Patterns of epithelial expression of Fos protein suggest important role in the transition from viable to cornified cell during keratinization. Development 111(2):253-8. [PubMed: 1909952] [MGI Ref ID J:32257]
Guenet JL; Salzgeber B; Tassin MT. 1979. Repeated epilation: a genetic epidermal syndrome in mice. J Hered 70(2):90-4. [PubMed: 479550] [MGI Ref ID J:6200]
Herron BJ; Liddell RA; Parker A; Grant S; Kinne J; Fisher JK; Siracusa LD. 2005. A mutation in stratifin is responsible for the repeated epilation (Er) phenotype in mice. Nat Genet 37(11):1210-2. [PubMed: 16200063] [MGI Ref ID J:101891]
Holbrook KA; Dale BA; Brown KS. 1982. Abnormal epidermal keratinization in the repeated epilation mutant mouse. J Cell Biol 92(2):387-97. [PubMed: 6174530] [MGI Ref ID J:6708]
Hunsicker. 1960. Repeated epilation, Er Mouse News Lett 23:58-9. [MGI Ref ID J:29020]
Jones AH; Lehman P; Dale BA. 1992. Altered retinoid distribution in the repeated epilation (Er) mutant mouse. J Craniofac Genet Dev Biol 12(2):63-75. [PubMed: 1613075] [MGI Ref ID J:1467]
Li Q; Lu Q; Estepa G; Verma IM. 2005. Identification of 14-3-3sigma mutation causing cutaneous abnormality in repeated-epilation mutant mouse. Proc Natl Acad Sci U S A 102(44):15977-82. [PubMed: 16239341] [MGI Ref ID J:102931]
Li Q; Sambandam SA; Lu HJ; Thomson A; Kim SH; Lu H; Xin Y; Lu Q. 2011. 14-3-3sigma and p63 play opposing roles in epidermal tumorigenesis. Carcinogenesis 32(12):1782-8. [PubMed: 21926108] [MGI Ref ID J:178010]
Lu Q; Xin Y; Ye F; Foulks G; Li Q. 2011. 14-3-3{sigma} Controls Corneal Epithelium Homeostasis and Wound Healing. Invest Ophthalmol Vis Sci 52(5):2389-96. [PubMed: 21228373] [MGI Ref ID J:171535]
Lutzner MA; Guenet JL; Breitburd F. 1985. Multiple cutaneous papillomas and carcinomas that develop spontaneously in a mouse mutant, the repeated epilation heterozygote Er/+. J Natl Cancer Inst 75(1):161-6. [PubMed: 2989601] [MGI Ref ID J:12025]
Richardson RJ; Dixon J; Malhotra S; Hardman MJ; Knowles L; Boot-Handford RP; Shore P; Whitmarsh A; Dixon MJ. 2006. Irf6 is a key determinant of the keratinocyte proliferation-differentiation switch. Nat Genet 38(11):1329-34. [PubMed: 17041603] [MGI Ref ID J:116077]
Salzgeber B; Guenet JL. 1984. Studies on "Repeated Epilation" Mouse Mutant Embryos: II. Development of limb, tail and skin defects J Craniofac Genet Dev Biol 4:95-114. [MGI Ref ID J:148459]
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Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.
Pricing and Purchasing
Pricing, Supply Level & Notes, Controls
| Pricing for USA, Canada and Mexico shipping destinations |
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Cryopreserved
Cryopreserved Mice - Ready for Recovery
Animals Provided
Price (US dollars $) Cryorecovery* $3000.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Standard Supply
Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.
Supply Notes
- Cryorecovery - Standard.
Progeny testing is not required.
The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 11 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).
| Pricing for International shipping destinations |
|
Cryopreserved
Cryopreserved Mice - Ready for Recovery
Animals Provided
Price (US dollars $) Cryorecovery* $3900.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Standard Supply
Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.
Supply Notes
- Cryorecovery - Standard.
Progeny testing is not required.
The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 11 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).
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Standard Supply
Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.
General Supply Notes
- Genomic DNA is available for this strain from the Mouse DNA Resource.
Payment Terms and Conditions
Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.
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The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering Information
JAX® Mice
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JAX® Mice, Products & Services Conditions of Use
"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.No Warranty
MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.
In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.
No Liability
In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.
MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.
The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.
Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.