Strain Name:

B6CBACa Aw-J/A-SfnEr/J

Stock Number:

000515

Availability:

Repository-Cryopreserved

Description

Strain Information

Former Names B6CBACa Aw-J/A-Er/J    (Changed: 30-NOV-05 )
Type Mutant Strain; Spontaneous Mutation;
Specieslaboratory mouse
GenerationN3F1N1

Related Strains

View Strains carrying   Aw-J     (31 strains)

Strains carrying other alleles of a
003301   (C57BL/6J x C3H-Eya1bor)F1/J
000251   AEJ.Cg-ae +/a Gdf5bp-H/J
000202   AEJ/Gn-bd/J
000199   AEJ/GnLeJ
000427   B10.CE-H13b Aw/(30NX)SnJ
000420   B10.LP-H13b Aw/Sn
000477   B10.PA-Pldnpa H3e at/SnJ
000419   B10.UW-H3b we Pax1un at/SnJ
003879   B10;TFLe-a/a T tf/+ tf/J
001538   B6 x B6C3Sn a/A-T(1;9)27H/J
000916   B6 x B6C3Sn a/A-T(5;12)31H/J
000602   B6 x B6C3Sn a/A-T(8;16)17H/J
002083   B6 x B6EiC3 a/A-T(7;16)235Dn/J
000507   B6 x B6EiC3 a/A-Otcspf/J
000618   B6 x FSB/GnEi a/a Ctslfs/J
000577   B6 x STOCK a Oca2p Hps5ru2 Ednrbs/J
000601   B6 x STOCK a/a T(7;18)50H/J
000592   B6 x STOCK T(2;4)13H a/J
000769   B6.C/(HZ18)By-at-44J/J
000001   B6.C3 A/a Mgrn1md/J
000203   B6.C3-Aiy/a/J
001572   B6.C3-am-J/J
000017   B6.C3Fe-Avy/J
000628   B6.CE-A Amy1b Amy2b/J
005505   B6.Cg-Ay Slc7a11sut/LmLlp
000021   B6.Cg-Ay/J
004200   B6;CBACa Aw-J/A-Npr2cn-2J/J
000785   B6;D2-a Es1e/J
000604   B6C3 a/A-T(10;13)199H +/+ Lystbg-J/J or Lystbg-2J/J
002807   B6C3Fe a/a-Meox2fla/J
000224   B6C3Fe a/a-Scyl1mdf/J
001037   B6C3Fe a/a-Agtpbp1pcd/J
000221   B6C3Fe a/a-Alx4lst-J/J
002062   B6C3Fe a/a-Atp7aMo-8J/J
001756   B6C3Fe a/a-Cacng2stg/J
001815   B6C3Fe a/a-Col1a2oim/J
000231   B6C3Fe a/a-Csf1op/J
000209   B6C3Fe a/a-Dh/J
000211   B6C3Fe a/a-Dstdt-J/J
000210   B6C3Fe a/a-Edardl-J/J
000207   B6C3Fe a/a-Edaraddcr/J
000182   B6C3Fe a/a-Eef1a2wst/J
001278   B6C3Fe a/a-Glra1spd/J
000241   B6C3Fe a/a-Glrbspa/J
002875   B6C3Fe a/a-Hoxd13spdh/J
000304   B6C3Fe a/a-Krt71Ca Scn8amed-J/J
000226   B6C3Fe a/a-Largemyd/J
000636   B6C3Fe a/a-Lmx1adr-J/J
001280   B6C3Fe a/a-Lse/J
001573   B6C3Fe a/a-MitfMi/J
001035   B6C3Fe a/a-Napahyh/J
000181   B6C3Fe a/a-Otogtwt/J
000278   B6C3Fe a/a-Papss2bm Hps1ep Hps6ru/J
000205   B6C3Fe a/a-Papss2bm/J
002078   B6C3Fe a/a-Pcdh15av-2J/J
000246   B6C3Fe a/a-Pitpnavb/J
001430   B6C3Fe a/a-Ptch1mes/J
000506   B6C3Fe a/a-Qkqk/J
000235   B6C3Fe a/a-Relnrl/J
000237   B6C3Fe a/a-Rorasg/J
000290   B6C3Fe a/a-Sox10Dom/J
000230   B6C3Fe a/a-Tcirg1oc/J
003612   B6C3Fe a/a-Trak1hyrt/J
001512   B6C3Fe a/a-Ttnmdm/J
001607   B6C3Fe a/a-Unc5crcm/J
000005   B6C3Fe a/a-Wc/J
000243   B6C3Fe a/a-Wnt1sw/J
000248   B6C3Fe a/a-Xpl/J
001750   B6C3Fe a/a-XsJ/J
000624   B6C3Fe a/a-anx/J
003020   B6C3Fe a/a-dep/J
002018   B6C3Fe a/a-din/J
002339   B6C3Fe a/a-nma/J
000240   B6C3Fe a/a-soc/J
000063   B6C3Fe a/a-sy/J
001055   B6C3Fe a/a-tip/J
000245   B6C3Fe a/a-tn/J
000065   B6C3Fe a/a-we Pax1un at/J
000296   B6C3Fe-a/a Hoxa13Hd Mcoln3Va-J/J
000019   B6C3Fe-a/a-Itpr1opt/J
001022   B6C3FeF1/J a/a
001752   B6CBCa Aw-J/A-T(7;15)9H/J
000971   B6EiC3 a/A-Och/J
000551   B6EiC3 a/A-Tbx15de-H/J
006450   B6EiC3 a/A-Vss/J
000557   B6EiC3-+ a/LnpUl A/J
000504   B6EiC3Sn a/A-Cacnb4lh/J
000553   B6EiC3Sn a/A-Egfrwa2 Wnt3avt/J
000503   B6EiC3Sn a/A-Gy/J
001811   B6EiC3Sn a/A-Otcspf-ash/J
002343   B6EiC3Sn a/A-Otcspf/J
000391   B6EiC3Sn a/A-Pax6Sey-Dey/J
001924   B6EiC3Sn a/A-Ts(1716)65Dn
001923   B6EiC3Sn a/A-Ts(417)2Lws Tim/J
000200   C3FeB6 A/Aw-J-Ankank/J
000638   C3FeB6 A/Aw-J-Spnb4qv-J/J
000225   C3FeLe.B6 a/a-Ptpn6me/J
000198   C3FeLe.B6-a/J
000291   C3FeLe.Cg-a/a Hm KitlSl Krt71Ca-J/J
001272   C3H/HeSnJ-Ahvy/J
000099   C3HeB/FeJ-Avy/J
001886   C3HeB/FeJLe a/a-gnd/J
000584   C57BL/6J-+ T(1;2)5Ca/a +/J
000258   C57BL/6J-Ai/a/J
000774   C57BL/6J-Asy/a/J
000055   C57BL/6J-at-33J/J
000070   C57BL/6J-atd/J
000284   CWD/LeJ
000670   DBA/1J
000671   DBA/2J
001057   HPT/LeJ
000260   JGBF/LeJ
002468   KK.Cg-Ay/J
000262   LS/LeJ
000283   LT.CAST-A/J
000265   MY/HuLeJ
000308   SSL/LeJ
001759   STOCK A Tyrc Sha/J
001427   STOCK Aw us/J
000994   STOCK a Myo5ad Mregdsu/J
000064   STOCK a Tyrp1b Sisi/J
002238   STOCK a Tyrp1b shmy/J
001433   STOCK a skt/J
000579   STOCK a tp/J
000319   STOCK a us/J
002648   STOCK a/a Cln6nclf/J
000317   STOCK a/a Egfrwa2/J
000302   STOCK a/a MitfMi-wh +/+ Itpr1opt/J
000286   STOCK a/a Myo5ad fd/+ +/J
000206   STOCK a/a Tyrc-h/J
001432   STOCK a/a Tyrp1b sks/Tyrp1b +/J
000281   STOCK a/a ma ft/ma ft/J
000312   STOCK stb + a/+ Fignfi a/J
000596   STOCK T(2;11)30H/+ x AEJ-a Gdf5bp-H/J or A/J-a Gdf5bp-J/J
000970   STOCK T(2;16)28H A/T(2;16)28H a/J
000590   STOCK T(2;4)1Sn a/J
000594   STOCK T(2;8)26H a/T(2;8)26H a Tyrp1+/Tyrp1b/J
000623   TR/DiEiJ
View Strains carrying other alleles of a     (138 strains)

Phenotype

Phenotype Information

Mammalian Phenotype Terms assigned by genotype

SfnEr/Sfn+

        B6CBACa Aw-J/A-SfnEr/J
  • skin/coat/nails phenotype
  • premature hair loss (MGI Ref ID J:102931)
    • repeated hair loss in adults

SfnEr/SfnEr

        B6CBACa Aw-J/A-SfnEr/J
  • lethality-prenatal/perinatal
  • perinatal lethality (MGI Ref ID J:102931)
    • die at birth due to respiratory stress
  • respiratory system phenotype
  • respiratory distress (MGI Ref ID J:102931)
  • skin/coat/nails phenotype
  • abnormal granular layer morphology (MGI Ref ID J:102931)
    • the thickened epidermis lacks the stratum granulosum
  • abnormal keratinocyte differentiation (MGI Ref ID J:102931)
    • failure of keratinocyte terminal differentiation; epidermis cells do not differentiate into mature granular and cornified cells
  • absent cornified layer (MGI Ref ID J:102931)
    • the thickened epidermis lacks the stratum corneum
  • epidermal hyperplasia (MGI Ref ID J:102931)
  • shiny skin (MGI Ref ID J:102931)
  • thickened epidermis (MGI Ref ID J:102931)
  • craniofacial phenotype
  • abnormal craniofacial development (MGI Ref ID J:102931)
    • fusion of the epithelium of the oral cavity
  • limbs/digits/tail phenotype
  • short limbs (MGI Ref ID J:102931)
    • stumpy legs
  • short tail (MGI Ref ID J:102931)
    • stumpy tail

The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.

SfnEr/Sfn+

        either: (involves: 129/Sv * C57BL/6) or (involves: C57BL/6)
  • lethality-postnatal
  • lethality at weaning (MGI Ref ID J:6200)
    • increased mortality starting at about the time hair loss starts and continuing through weaning and a little after
    • mice surviving the post weaning period are fertile and live normal lifespans
  • skin/coat/nails phenotype
  • premature hair loss (MGI Ref ID J:6200)
    • first coat lost by 3 weeks then quickly replaced and lost again
    • hair loss begins around eyes and nose
    • normal until around 13 days when hair loss begins
  • sparse hair (MGI Ref ID J:29020)
  • growth/size phenotype
  • postnatal growth retardation (MGI Ref ID J:6200)
    • starting about the same time as hair loss

SfnEr/Sfn+

        involves: 129S/SvEv * C57BL/6By
  • tumorigenesis
  • skin papilloma (MGI Ref ID J:12025)
    • 67% frequency in mice older than 6 months
    • begin as small sessile or pedunculated papillomas, then most enlarge, and many develop horns
    • no evidence of virus particles
  • squamous cell carcinoma (MGI Ref ID J:12025)
    • 67% frequency in mice older than 6 months
    • squamous cell carcinomas in the fleshy base of large cutaneous horns
    • no evidence of virus particles
  • skin/coat/nails phenotype
  • skin papilloma (MGI Ref ID J:12025)
    • 67% frequency in mice older than 6 months
    • begin as small sessile or pedunculated papillomas, then most enlarge, and many develop horns
    • no evidence of virus particles

SfnEr/SfnEr

        either: (involves: 129/Sv * C57BL/6) or (involves: C57BL/6)
  • lethality-prenatal/perinatal
  • neonatal lethality (MGI Ref ID J:6200)
    • born alive
    • die shortly after birth of acute respiratory distress due to a closed oral cavity
  • respiratory system phenotype
  • abnormal nose morphology (MGI Ref ID J:6200)
    • oral cavity closed
    • abnormal external nares morphology (MGI Ref ID J:6200)
      • nostrils present only as two very small holes
  • abnormal respiratory signs/symptoms (MGI Ref ID J:6200)
    • respiratory distress (MGI Ref ID J:6200)
      • acute respiratory distress is cause of death
  • respiratory failure (MGI Ref ID J:6200)
    • pups try to breath but cannot due to closed oral cavity
  • skin/coat/nails phenotype
  • abnormal epidermal layer morphology (MGI Ref ID J:6708)
    • abnormal basal cell layer morphology (MGI Ref ID J:6200)
      • stratum germinativum underdeveloped
      • fewer desmosomes between basal layer cells
    • abnormal cornified layer morphology (MGI Ref ID J:6708)
      • cells less organized
      • true cornified zone not seen
    • abnormal granular layer morphology (MGI Ref ID J:6708)
      • cells less organized
      • increased number of granular cell layers
  • decreased hair follicle number (MGI Ref ID J:6200)
    • hair follicles very rare
  • shiny skin (MGI Ref ID J:6200)
  • thin skin (MGI Ref ID J:6200)
    • extremely thin and smooth
    • inconsistent thickness
  • digestive/alimentary phenotype
  • abnormal anus morphology (MGI Ref ID J:6200)
    • anal orifice undetectable
  • abnormal perineum morphology (MGI Ref ID J:6200)
    • urogenital orifices undetectable
  • cleft palate (MGI Ref ID J:6200)
    • palatal shelves fail to fuse along midline
  • herniated intestine (MGI Ref ID J:6200)
    • 1-2 external loops of the bowel occasionally seen (Celosomia)
  • liver/biliary system phenotype
  • abnormal liver morphology (MGI Ref ID J:6200)
    • sometimes partially protrudes from the body cavity
  • craniofacial phenotype
  • abnormal orofacial morphology (MGI Ref ID J:6200)
    • abnormal mouth morphology (MGI Ref ID J:6200)
      • closed
      • complete fusion of premaxillary and lower jaw epithelia
      • tongue fused to both premaxilla and mandible
      • cleft palate (MGI Ref ID J:6200)
        • palatal shelves fail to fuse along midline
    • thin lip (MGI Ref ID J:6200)
  • short snout (MGI Ref ID J:6200)
    • truncated
  • small ears (MGI Ref ID J:6200)
    • pinna reduced in size
  • limbs/digits/tail phenotype
  • abnormal phalanx morphology (MGI Ref ID J:6200)
    • phalanges sometimes fused (symphalangy)
    • complete disappearance of distal phalangies sometimes
    • brachyphalangia (MGI Ref ID J:6200)
  • abnormal radius morphology (MGI Ref ID J:6200)
    • radius held closer to humerus
  • decreased caudal vertebrae number (MGI Ref ID J:6200)
    • 10-12 caudal vertebrae missing
  • short limbs (MGI Ref ID J:6200)
    • limbs and tail greatly shortened
  • skeleton phenotype
  • abnormal axial skeleton morphology (MGI Ref ID J:6200)
    • decreased caudal vertebrae number (MGI Ref ID J:6200)
      • 10-12 caudal vertebrae missing
    • kyphosis (MGI Ref ID J:6200)
      • accentuated dorsal curvature and head shifted slightly forward along body axis
  • abnormal phalanx morphology (MGI Ref ID J:6200)
    • phalanges sometimes fused (symphalangy)
    • complete disappearance of distal phalangies sometimes
    • brachyphalangia (MGI Ref ID J:6200)
  • abnormal radius morphology (MGI Ref ID J:6200)
    • radius held closer to humerus
  • reproductive system phenotype
  • abnormal perineum morphology (MGI Ref ID J:6200)
    • urogenital orifices undetectable
  • hearing/vestibular/ear phenotype
  • small ears (MGI Ref ID J:6200)
    • pinna reduced in size
  • vision/eye phenotype
  • microphthalmia (MGI Ref ID J:6200)

Research Applications

This mouse can be used to support research in many areas including:

SfnEr related

Dermatology Research
Skin and Hair Texture Defects

Developmental Biology Research
Craniofacial and Palate Defects (cleft palate)
Skeletal Defects

Genes & Alleles

Gene & Allele Information

Allele Symbol Aw-J
Allele Name white bellied agouti Jackson
Common Name(s) AWJ;
Strain of OriginC57BL/6J
Gene Symbol and Name a, nonagouti
Chromosome 2
Gene Common Name(s) AGSW; AGTI; AGTIL; ASP; As; MGC126092; MGC126093; SHEP9; agouti; agouti signal protein; agouti suppressor;
 
Allele Symbol SfnEr
Allele Name repeated epilation
Common Name(s) Er;
Gene Symbol and Name Sfn, stratifin
Chromosome 4
Gene Common Name(s) 14-3-3 sigma; Er; MME1; YWHAS; Ywhas; repeated epilation; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, sigma polypeptide;
General Note Sfn is on Chr 4 close to pupoid fetus (pf), a mutant which SfnEr closely resembles.
Molecular Note A single T insertion at base pair 622 causes a frame shift mutation at amino acid residue 207 truncating the C-terminus of the protein. This eliminates residues required for ligand interaction. Production of truncated protein was demonstrated immunologically. The hair-loss phenotype could be rescued using a Sfn containing transgene. [MGI Ref ID J:101891]

Genotyping

Genotyping Information

Genotyping Protocols

Aw-J, STD PCR, vers. 1

Helpful Links

Optimizing PCR Protocols

References

References

Additional References

Aw-J related

Aberg T; Wang XP; Kim JH; Yamashiro T; Bei M; Rice R; Ryoo HM; Thesleff I. 2004. Runx2 mediates FGF signaling from epithelium to mesenchyme during tooth morphogenesis. Dev Biol 270(1):76-93. [PubMed: 15136142]  [MGI Ref ID J:92174]

Barsh GS; Epstein CJ. 1989. Physical and genetic characterization of a 75-kilobase deletion associated with al, a recessive lethal allele at the mouse agouti locus. Genetics 121(4):811-8. [PubMed: 2566558]  [MGI Ref ID J:9799]

Baurle J; Vogten H; Grusser-Cornehls U. 1998. Course and targets of the calbindin D-28k subpopulation of primary vestibular afferents. J Comp Neurol 402(1):111-28. [PubMed: 9831049]  [MGI Ref ID J:118430]

Boran T; Lesot H; Peterka M; Peterkova R. 2005. Increased apoptosis during morphogenesis of the lower cheek teeth in tabby/EDA mice. J Dent Res 84(3):228-33. [PubMed: 15723861]  [MGI Ref ID J:112546]

Cui CY; Hashimoto T; Grivennikov SI; Piao Y; Nedospasov SA; Schlessinger D. 2006. Ectodysplasin regulates the lymphotoxin-beta pathway for hair differentiation. Proc Natl Acad Sci U S A 103(24):9142-7. [PubMed: 16738056]  [MGI Ref ID J:111051]

Cui CY; Kunisada M; Esibizione D; Grivennikov SI; Piao Y; Nedospasov SA; Schlessinger D. 2007. Lymphotoxin-beta regulates periderm differentiation during embryonic skin development. Hum Mol Genet 16(21):2583-90. [PubMed: 17673451]  [MGI Ref ID J:129949]

Dickie MM. 1969. Mutations at the agouti locus in the mouse. J Hered 60(1):20-5. [PubMed: 5798139]  [MGI Ref ID J:30922]

Granholm DE; Reese RN; Granholm NH. 1996. Agouti alleles alter cysteine and glutathione concentrations in hair follicles and serum of mice (A y/a, A wJ/A wJ, and a/a). J Invest Dermatol 106(3):559-63. [PubMed: 8648194]  [MGI Ref ID J:32132]

Granholm DE; Reese RN; Granholm NH. 1995. Agouti alleles influence thiol concentrations in hair follicles and extrafollicular tissues of mice (Ay/a, AwJ/AwJ, a/a). Pigment Cell Res 8(6):302-6. [PubMed: 8789738]  [MGI Ref ID J:31403]

Jones JM; Huang JD; Mermall V; Hamilton BA; Mooseker MS; Escayg A; Copeland NG; Jenkins NA; Meisler MH. 2000. The mouse neurological mutant flailer expresses a novel hybrid gene derived by exon shuffling between Gnb5 and Myo5a. Hum Mol Genet 9(5):821-8. [PubMed: 10749990]  [MGI Ref ID J:61324]

Kappenman KE; Dvoracek MA; Harvison GA; Fuller BB; Granholm NH. 1992. Tyrosinase abundance and activity in murine hairbulb melanocytes of agouti mutants (C57BL/6J-a/a, Ay/a, and AwJ/AwJ). Pigment Cell Res Suppl 2:79-83. [PubMed: 1409442]  [MGI Ref ID J:1295]

Katoh A; Yoshida T; Himeshima Y; Mishina M; Hirano T. 2005. Defective control and adaptation of reflex eye movements in mutant mice deficient in either the glutamate receptor delta2 subunit or Purkinje cells. Eur J Neurosci 21(5):1315-26. [PubMed: 15813941]  [MGI Ref ID J:101081]

Lee M; Kim A; Chua SC Jr; Obici S; Wardlaw SL. 2007. Transgenic MSH overexpression attenuates the metabolic effects of a high-fat diet. Am J Physiol Endocrinol Metab 293(1):E121-31. [PubMed: 17374695]  [MGI Ref ID J:126508]

Lu W; Tsirka SE. 2002. Partial rescue of neural apoptosis in the Lurcher mutant mouse through elimination of tissue plasminogen activator. Development 129(8):2043-50. [PubMed: 11934869]  [MGI Ref ID J:111363]

Mayer TC; Fishbane JL. 1972. Mesoderm-ectoderm interaction in the production of the agouti pigmentation pattern in mice. Genetics 71(2):297-303. [PubMed: 4558326]  [MGI Ref ID J:5288]

Mitsumori K; Yasuhara K; Mori I; Hayashi S; Shimo T; Onodera H; Nomura T; Hayashi Y. 1998. Pulmonary fibrosis caused by N-methyl-N-nitrosourethane inhibits lung tumorigenesis by urethane in transgenic mice carrying the human prototype c-Ha-ras gene. Cancer Lett 129(2):181-90. [PubMed: 9719460]  [MGI Ref ID J:52138]

Monroe DG; Wipf LP; Diggins MR; Matthees DP; Granholm NH. 1998. Agouti-related maturation and tissue distribution of alpha-Melanocyte Stimulating Hormone in wild-type (AwJ/AwJ) and mutant (Ay/a,a/a) mice. Pigment Cell Res 11(5):310-3. [PubMed: 9877102]  [MGI Ref ID J:52183]

Mullen RJ. 1974. A<w-J> - white-bellied agouti-J Mouse News Lett 50:38.  [MGI Ref ID J:64104]

Mustonen T; Ilmonen M; Pummila M; Kangas AT; Laurikkala J; Jaatinen R; Pispa J; Gaide O; Schneider P; Thesleff I; Mikkola ML. 2004. Ectodysplasin A1 promotes placodal cell fate during early morphogenesis of ectodermal appendages. Development 131(20):4907-19. [PubMed: 15371307]  [MGI Ref ID J:128256]

O'donnell SM; Hansberger MW; Connolly JL; Chappell JD; Watson MJ; Pierce JM; Wetzel JD; Han W; Barton ES; Forrest JC; Valyi-Nagy T; Yull FE; Blackwell TS; Rottman JN; Sherry B; Dermody TS. 2005. Organ-specific roles for transcription factor NF-kappaB in reovirus-induced apoptosis and disease. J Clin Invest 115(9):2341-2350. [PubMed: 16100570]  [MGI Ref ID J:100906]

Peng J; Wu Z; Wu Y; Hsu M; Stevenson FF; Boonplueang R; Roffler-Tarlov SK; Andersen JK. 2002. Inhibition of caspases protects cerebellar granule cells of the weaver mouse from apoptosis and improves behavioral phenotype. J Biol Chem 277(46):44285-91. [PubMed: 12221097]  [MGI Ref ID J:119427]

Peng J; Xie L; Stevenson FF; Melov S; Di Monte DA; Andersen JK. 2006. Nigrostriatal dopaminergic neurodegeneration in the weaver mouse is mediated via neuroinflammation and alleviated by minocycline administration. J Neurosci 26(45):11644-51. [PubMed: 17093086]  [MGI Ref ID J:114943]

Poole TW. 1975. Dermal-epidermal interactions and the action of alleles at the agouti locus in the mouse. Dev Biol 42(2):203-10. [PubMed: 1090472]  [MGI Ref ID J:5519]

Probst FJ; Cooper ML; Cheung SW; Justice MJ. 2008. Genotype, phenotype, and karyotype correlation in the XO mouse model of Turner Syndrome. J Hered 99(5):512-7. [PubMed: 18499648]  [MGI Ref ID J:138994]

Smith DE; Xu SG. 2003. Ultrastructural organization of GABA-like immunoreactive profiles in the weaver substantia nigra. J Neurocytol 32(3):293-303. [PubMed: 14724391]  [MGI Ref ID J:121345]

Vandenput L; Swinnen JV; Boonen S; Van Herck E; Erben RG; Bouillon R; Vanderschueren D. 2004. Role of the androgen receptor in skeletal homeostasis: the androgen-resistant testicular feminized male mouse model. J Bone Miner Res 19(9):1462-70. [PubMed: 15312246]  [MGI Ref ID J:111491]

Wu Q; Miller RH; Ransohoff RM; Robinson S; Bu J; Nishiyama A. 2000. Elevated levels of the chemokine GRO-1 correlate with elevated oligodendrocyte progenitor proliferation in the jimpy mutant. J Neurosci 20(7):2609-17. [PubMed: 10729341]  [MGI Ref ID J:109469]

Yamago G; Takata Y; Furuta I; Urase K; Momoi T; Huh N. 2001. Suppression of hair follicle development inhibits induction of sonic hedgehog, patched, and patched-2 in hair germs in mice. Arch Dermatol Res 293(9):435-41. [PubMed: 11758785]  [MGI Ref ID J:116953]

Yoshida T; Katoh A; Ohtsuki G; Mishina M; Hirano T. 2004. Oscillating Purkinje neuron activity causing involuntary eye movement in a mutant mouse deficient in the glutamate receptor delta2 subunit. J Neurosci 24(10):2440-8. [PubMed: 15014119]  [MGI Ref ID J:97010]

van Empel VP; Bertrand AT; van der Nagel R; Kostin S; Doevendans PA; Crijns HJ; de Wit E; Sluiter W; Ackerman SL; De Windt LJ. 2005. Downregulation of apoptosis-inducing factor in harlequin mutant mice sensitizes the myocardium to oxidative stress-related cell death and pressure overload-induced decompensation. Circ Res 96(12):e92-e101. [PubMed: 15933268]  [MGI Ref ID J:110278]

SfnEr related
Fisher C. 2000. IKKalpha-/- mice share phenotype with pupoid fetus (pf/pf) and repeated epilation (Er/Er) mutant mice. Trends Genet 16(11):482-4. [PubMed: 11203384]  [MGI Ref ID J:65526]

Fisher C; Byers MR; Iadarola MJ; Powers EA. 1991. Patterns of epithelial expression of Fos protein suggest important role in the transition from viable to cornified cell during keratinization. Development 111(2):253-8. [PubMed: 1909952]  [MGI Ref ID J:32257]

Guenet JL; Salzgeber B; Tassin MT. 1979. Repeated epilation: a genetic epidermal syndrome in mice. J Hered 70(2):90-4. [PubMed: 479550]  [MGI Ref ID J:6200]

Herron BJ; Liddell RA; Parker A; Grant S; Kinne J; Fisher JK; Siracusa LD. 2005. A mutation in stratifin is responsible for the repeated epilation (Er) phenotype in mice. Nat Genet 37(11):1210-2. [PubMed: 16200063]  [MGI Ref ID J:101891]

Holbrook KA; Dale BA; Brown KS. 1982. Abnormal epidermal keratinization in the repeated epilation mutant mouse. J Cell Biol 92(2):387-97. [PubMed: 6174530]  [MGI Ref ID J:6708]

Hunsicker. 1960. Repeated epilation, Er Mouse News Lett 23:58-9.  [MGI Ref ID J:29020]

Jones AH; Lehman P; Dale BA. 1992. Altered retinoid distribution in the repeated epilation (Er) mutant mouse. J Craniofac Genet Dev Biol 12(2):63-75. [PubMed: 1613075]  [MGI Ref ID J:1467]

Li Q; Lu Q; Estepa G; Verma IM. 2005. Identification of 14-3-3sigma mutation causing cutaneous abnormality in repeated-epilation mutant mouse. Proc Natl Acad Sci U S A 102(44):15977-82. [PubMed: 16239341]  [MGI Ref ID J:102931]

Lutzner MA; Guenet JL; Breitburd F. 1985. Multiple cutaneous papillomas and carcinomas that develop spontaneously in a mouse mutant, the repeated epilation heterozygote Er/+. J Natl Cancer Inst 75(1):161-6. [PubMed: 2989601]  [MGI Ref ID J:12025]

Richardson RJ; Dixon J; Malhotra S; Hardman MJ; Knowles L; Boot-Handford RP; Shore P; Whitmarsh A; Dixon MJ. 2006. Irf6 is a key determinant of the keratinocyte proliferation-differentiation switch. Nat Genet 38(11):1329-34. [PubMed: 17041603]  [MGI Ref ID J:116077]

Sundberg JP (ed.). 1994. . In: Handbook of Mouse Mutations with Skin and Hair Abnormalities: Animal Models and Biomedical Tools. CRC Press, Boca Raton.  [MGI Ref ID J:30359]

Tassin MT; Salzgeber B; Guenet JL. 1983. Studies on repeated epilation mouse mutant embryos: I. Development of facial malformations. J Craniofac Genet Dev Biol 3(3):289-307. [PubMed: 6643653]  [MGI Ref ID J:7243]

Health & husbandry

Health & Colony Maintenance Information

Currently there no information available for this strain. This may be due to the supply level of this strain.

Purchasing information

Pricing, Supply Level & Notes, Controls, General Terms & Conditions

Pricing

Pricing for USA, Canada and Mexico shipping destinations             View   International   Pricing
Weeks of AgePrice*Gender
Cryorecovery Fee $1900.00
*Price(s) in US dollars ($)

Supply Details

Standard SupplyRepository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information.
Supply Notes
  • Cryorecovery - Standard.
    The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two males and two females (two pairs) will be provided, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the delivery time to approximately 25 weeks. At least one member of each pair will be of known genotype and will carry the mutation if it is a mutant strain. Please note that pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Price represents a repository maintenance fee, which includes the cost of recovery of the strain from the cryopreservation resource and the periodic replacement of the frozen embryos used for recovery.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
    One to two pairs will be recovered to establish a Dedicated Supply of mice. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 or 1-207-288-5845.

  • Genomic DNA is available for this strain from the Mouse DNA Resource.

Pricing for International shipping destinations             View   USA, Canada and Mexico   Pricing
Weeks of AgePrice*Gender
Cryorecovery Fee $2470.00
*Price(s) in US dollars ($)

Supply Details

Standard SupplyRepository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information.
Supply Notes
  • Cryorecovery - Standard.
    The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two males and two females (two pairs) will be provided, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the delivery time to approximately 25 weeks. At least one member of each pair will be of known genotype and will carry the mutation if it is a mutant strain. Please note that pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Price represents a repository maintenance fee, which includes the cost of recovery of the strain from the cryopreservation resource and the periodic replacement of the frozen embryos used for recovery.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
    One to two pairs will be recovered to establish a Dedicated Supply of mice. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 or 1-207-288-5845.

  • Genomic DNA is available for this strain from the Mouse DNA Resource.

General Terms and Conditions

View JAX® Mice & Services Conditions of Use.

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
Ordering and Purchasing Information

      Purchasing Information
      JAX® Mice Orders
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Contact Information
Orders & Technical Support
Tel: 800.422.6423 or 207.288.5845
Fax: 207.288.6150
Technical Support Email Form


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