Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Former Names Foxn1nu-s    (Changed: 15-DEC-04 ) Type Congenic; Mutant Strain; Spontaneous Mutation; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Species laboratory mouse Background Strain C57BL/6J Donor Strain AKR/J Generation N10

Description

Mice homozygous for the streaker spontaneous have a phenotype that is very similar to nude mice.

In an attempt to offer alleles on well-characterized or multiple genetic backgrounds, alleles are frequently moved to a genetic background different from that on which an allele was first characterized. This is the case for the strain above. It should be noted that the phenotype could vary from that originally described. We will modify the strain description if necessary as published results become available.

Related Strains

Strains carrying   Foxn1^nu-str allele

000820

AKR/J-Foxn1nu-str/J

View Strains carrying   Foxn1^nu-str     (1 strain)

Strains carrying other alleles of Foxn1

000819	B6.Cg-Foxn1nu/J
000711	CByJ.Cg-Foxn1nu/J
002019	NU/J
003118	STOCK Es1e Foxn1nu/J

View Strains carrying other alleles of Foxn1     (4 strains)

Additional Web Information

Congenic Nomenclature

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms

      assigned by genotype

The following phenotype information may relate to a genetic background differing from this JAX^® Mice strain.

Foxn1^nu-str/Foxn1^nu-str

        AKR/J-Foxn1^nu-str/J

• life span-post-weaning/aging
• premature death (MGI Ref ID J:30715)
  • reduced life span due to susceptibility to infection (ave. 236 days)
• growth/size phenotype
• cachexia (MGI Ref ID J:30715)
  • "wasting disease"
• skin/coat/nails phenotype
• nude (MGI Ref ID J:24755)
• immune system phenotype
• abnormal immune system morphology (MGI Ref ID J:24755)
• abnormal immune system cell morphology (MGI Ref ID J:30715)
• decreased lymphocyte cell number (MGI Ref ID J:30715)
  • peripheral lymphocytes reduced to about 44.2% of white cells as opposed to 78% in controls
• decreased T cell number (MGI Ref ID J:30715)
  • reduced proliferative response to T-cell mitogens
• increased granulocyte number (MGI Ref ID J:30715)
• increased eosinophil cell number (MGI Ref ID J:30715)
  • slightly
• increased neutrophil cell number (MGI Ref ID J:30715)
• abnormal immune system organ morphology (MGI Ref ID J:30715)
• abnormal Peyer's patch morphology (MGI Ref ID J:30715)
  • tissue between primary nodules severely depleted
• abnormal Peyer's patch germinal center morphology (MGI Ref ID J:30715)
  • lack well developed germinal centers
• athymia (MGI Ref ID J:24755)
• lymph node hypoplasia (MGI Ref ID J:30715)
  • deep cortical areas of lymph nodes are severely depleted
• spleen hypoplasia (MGI Ref ID J:30715)
  • periarteriolar regions of spleen severely depleted
• abnormal immune system physiology (MGI Ref ID J:30715)
• abnormal humoral immune response (MGI Ref ID J:30715)
  • decreased humoral response to thymus dependent antigens
  • 20 fold reduction in IgM plaque forming response to sheep erythrocytes
• decreased immunoglobulin level (MGI Ref ID J:30715)
  • decreased serum Ig levels
• increased length of allograft survival (MGI Ref ID J:30715)
• tumorigenesis
• decreased tumor incidence (MGI Ref ID J:43880)
  • no chemically induced carcinogenesis observed in two stage protocols using DMBA and TPA
• increased resistance to lymphoma (MGI Ref ID J:30715)
  • refractory to thymic lymphoma
• sarcoma (MGI Ref ID J:30715)
  • lymphoreticular neoplasms observed (reticulum cell sarcoma)
• hematopoietic system phenotype
• athymia (MGI Ref ID J:24755)
• decreased lymphocyte cell number (MGI Ref ID J:30715)
  • peripheral lymphocytes reduced to about 44.2% of white cells as opposed to 78% in controls
• decreased T cell number (MGI Ref ID J:30715)
  • reduced proliferative response to T-cell mitogens
• increased granulocyte number (MGI Ref ID J:30715)
• increased eosinophil cell number (MGI Ref ID J:30715)
  • slightly
• increased neutrophil cell number (MGI Ref ID J:30715)
• spleen hypoplasia (MGI Ref ID J:30715)
  • periarteriolar regions of spleen severely depleted

View Research Applications

Research Applications

This mouse can be used to support research in many areas including:

Foxn1^nu-str related

Dermatology Research
Skin and Hair Texture Defects

Immunology and Inflammation Research
Immunodeficiency

Genes & Alleles

Gene & Allele Information

Allele Symbol		Foxn1nu-str
Allele Name		nude streaker
Allele Type		Spontaneous
Common Name(s)		nustr;
Strain of Origin		AKR/J
Gene Symbol and Name		Foxn1, forkhead box N1
Chromosome		11
Gene Common Name(s)		D11Bhm185e; DNA segment, Chr 11, Boehm 185, expressed; FKHL20; HNF-3/forkhead homolog 11; Hfh11; RONU; Rnu; WHN; nu; nude;
Molecular Note		A spontaneous mutation to nude called streaker arose in the AKR/J strain in 1974 at The Jackson Laboratory. An allele test confirmed that streaker is an allele of nude.

Genotyping

Genotyping Information

This strain will not have a genotyping protocol or one is not currently available.

Helpful Links

Optimizing PCR Protocols

References

References

Additional References

Hirasawa T; Yamashita H; Makino S. 1998. Genetic typing of the mouse and rat nude mutations by PCR and restriction enzyme analysis. Exp Anim 47(1):63-7. [PubMed: 9498115]  [MGI Ref ID J:46550]

Foxn1^nu-str related

Bedigian HG; Shultz LD; Meier H. 1979. Expression of endogenous murine leukaemia viruses in AKR/J streaker mice. Nature 279(5712):434-436. [PubMed: 16068183]  [MGI Ref ID J:12015]

Eicher EM. 1976. Spontaneous mutations - streaker (nu<str>) and ichthyosis (ic<J>) Mouse News Lett 54:40.  [MGI Ref ID J:24755]

Shultz LD; Bedigian HG; Heiniger HJ; Eicher EM. 1982. The congenitally athymic streaker mouse. In: Proceeding of the Third International Workshop on Nude Mice. Gustav Fischer, New York.  [MGI Ref ID J:30715]

Sundberg JP (ed.). 1994. . In: Handbook of Mouse Mutations with Skin and Hair Abnormalities: Animal Models and Biomedical Tools. CRC Press, Boca Raton.  [MGI Ref ID J:30359]

Sundberg JP; Sundberg BA; Beamer WG. 1997. Comparison of chemical carcinogen skin tumor induction efficacy in inbred, mutant, and hybrid strains of mice: Morphologic variations of induced tumors and absence of a papillomavirus cocarcinogen. Mol Carcinog 20(1):19-32. [PubMed: 9328433]  [MGI Ref ID J:43880]

Health & husbandry

Health & Colony Maintenance Information

Currently there no information available for this strain. This may be due to the supply level of this strain.

Purchasing information

Pricing, Supply Level & Notes, Controls, General Terms & Conditions

Pricing

Supply Details

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information.

Supply Notes

Cryorecovery of Strains Needing Progeny Testing. The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two untested males and two untested females (two pairs) will be recovered, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the overall recovery time to approximately 25 weeks. However, all pups recovered will be sent. Progeny testing is required to identify the genotype of mice of this strain, as a genotyping assay is not available. This type of testing involves breeding the recovered animals and assessing the phenotype of the offspring in order to identify animals carrying the mutation of interest. We can perform the progeny testing for you as a service or we can ship all recovered animals (at least two untested pairs) to you for progeny testing at your facility. If you perform the progeny testing, there is NO guarantee that a carrier will be identified. If we perform progeny testing as a service, additional breeding time will be required. In this case, when a male and female (one pair) are identified that carry the mutation, they and their offspring will be shipped. Delivery time for strains requiring progeny testing often exceeds 25 weeks and may take 12 months or more due to the difficulties in breeding some strains. The progeny testing cost is in addition to the recovery cost and is based on the number of boxes used and the time taken to produce the mice identified as carrying the mutation. Please note that identified pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Please contact Customer Service for more information on the cost of progeny testing for a strain: Tel: 1-800-422-6423 or 1-207-288-5845. Cryorecovery to establish a Dedicated Supply for greater quantities of mice One to two pairs will be recovered to establish a Dedicated Supply of mice. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 or 1-207-288-5845. Genomic DNA is available for this strain from the Mouse DNA Resource.

General Terms and Conditions

See Terms of Use

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

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Ordering and Purchasing Information

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Contact Information
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Tel: 800.422.6423 or 207.288.5845
Fax: 207.288.6150
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Terms of Use

Terms of Use

General Terms and Conditions

Contact information

General inquiries

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phone:	207-288-6470
fax:	207-288-6655

JAX^® Mice & Services Conditions of Use

“Each recipient institution, including its employees and other researchers under its control (RECIPIENT), of mice or services using mice from The Jackson Laboratory (TJL) agrees that such mice, descendants of those mice derived by inbreeding or crossbreeding, including unmodified derivatives of those mice or their descendants (“MICE”) shall not be: (i) used for any purpose other than the internal research of the RECIPIENT, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services with respect to MICE. Acceptance of MICE from TJL shall be deemed agreement by RECIPIENT to these conditions, and departure from these conditions requires The Jackson Laboratory’s prior written authorization.”

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of MICE, products or services, The Jackson Laboratory will, at its option, provide credit or replacement for the MICE or product received or the services provided.

No Liability

In no event shall The Jackson Laboratory, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, products or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of The Jackson Laboratory, its agents or employees. In purchasing or receiving MICE, products or services from The Jackson Laboratory, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges The Jackson Laboratory from all such causes of action or damages, and further agrees to defend and indemnify The Jackson Laboratory from any costs or damages arising out of any third party claims.

MICE and biological materials are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to The Jackson Laboratory’s MICE, products and services. In addition, special terms and conditions of sale of certain MICE, products and services may be set forth separately in The Jackson Laboratory web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, products and services by The Jackson Laboratory, and by its licensees and distributors.

Acceptance of delivery of MICE, products or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on The Jackson Laboratory, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, products services by The Jackson Laboratory.