Strain Name:

B6.C3Fe-Hps1ep/J

Stock Number:

000525

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Availability:

Cryopreserved - Ready for recovery

Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Former Names B6.C3Fe-ep/+    (Changed: 15-DEC-04 )
Type Congenic; Mutant Strain; Spontaneous Mutation;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Additional information on Congenic nomenclature.
Specieslaboratory mouse
Background Strain C57BL/6J
Donor Strain C3HeB/FeJ
GenerationN21p
Generation Definitions

Related Strains

Strains carrying   Hps1ep allele
000050   B6.C3Fe-H51 Hps1ep /ByJ
000278   B6C3Fe a/a-Papss2bm Hps1ep Hps6ru/J
View Strains carrying   Hps1ep     (2 strains)

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- Model with phenotypic similarity to human disease where etiologies involve orthologs. Human genes are associated with this disease. Orthologs of those genes appear in the mouse genotype(s).
Hermansky-Pudlak Syndrome 1; HPS1
Models with phenotypic similarity to human diseases where etiology is unknown or involving genes where ortholog is unknown.
Storage Pool Platelet Disease
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

Hps1ep/Hps1ep

        B6.C3Fe-Hps1ep/J
  • cellular phenotype
  • abnormal lysosome physiology
    • significant increase in lysosomal enzyme activity of beta-galactosidase and beta-glucuronidase, and to a lesser extent N-acetyl-beta-hexoseaminidase, in kidney extracts   (MGI Ref ID J:6801)
    • increased lysosomal enzyme secretion
      • thrombin stimulation of platelets results in approximately double the normal levels of secretion of beta-glucaronidase and beta-galactosidase   (MGI Ref ID J:7327)
  • immune system phenotype
  • abnormal NK cell physiology
    • lower natural killer cell activity   (MGI Ref ID J:6801)
  • alveolitis
    • mild lymphocytic infiltration of the alveolar septa but no fibrosis in some aged mice   (MGI Ref ID J:110157)
  • pigmentation phenotype
  • abnormal iris pigmentation
    • the iris is slightly dark   (MGI Ref ID J:141035)
  • abnormal melanosome morphology
    • marked increase in immature forms of melanosomes, with a shift of distribution of type IV melanosomes towards more elliptical forms   (MGI Ref ID J:80751)
  • decreased ear pigmentation
    • display a reduction in pigmentation of the ears   (MGI Ref ID J:99881)
  • decreased tail pigmentation
    • display a reduction in pigmentation of the tail   (MGI Ref ID J:99881)
  • hematopoietic system phenotype
  • abnormal NK cell physiology
    • lower natural killer cell activity   (MGI Ref ID J:6801)
  • decreased platelet ADP level
    • platelet ADP levels are much lower than in C57BL/6J controls   (MGI Ref ID J:7327)
  • decreased platelet ATP level
    • platelet ATP levels are much lower than in C57BL/6J controls   (MGI Ref ID J:7327)
  • decreased platelet serotonin level
    • 4.5 fold less platelet serotonin than in C57BL/6J control platelets   (MGI Ref ID J:7327)
    • platelet serotonin level is also lower than that of control when fed an atherogenic diet   (MGI Ref ID J:29748)
  • homeostasis/metabolism phenotype
  • decreased platelet serotonin level
    • 4.5 fold less platelet serotonin than in C57BL/6J control platelets   (MGI Ref ID J:7327)
    • platelet serotonin level is also lower than that of control when fed an atherogenic diet   (MGI Ref ID J:29748)
  • increased bleeding time
    • bleed time averaging over 14 minutes after tail nick is much greater than the 3.8 minutes for C57BL/6J controls   (MGI Ref ID J:7327)
  • cardiovascular system phenotype
  • increased susceptibility to atherosclerosis
    • on an atherogenic diet homozygotes develop larger atherosclerotic lesions in the aorta than C57BL/6J controls   (MGI Ref ID J:29748)
  • vision/eye phenotype
  • abnormal iris pigmentation
    • the iris is slightly dark   (MGI Ref ID J:141035)
  • craniofacial phenotype
  • decreased ear pigmentation
    • display a reduction in pigmentation of the ears   (MGI Ref ID J:99881)
  • hearing/vestibular/ear phenotype
  • decreased ear pigmentation
    • display a reduction in pigmentation of the ears   (MGI Ref ID J:99881)
  • limbs/digits/tail phenotype
  • decreased tail pigmentation
    • display a reduction in pigmentation of the tail   (MGI Ref ID J:99881)
  • integument phenotype
  • decreased ear pigmentation
    • display a reduction in pigmentation of the ears   (MGI Ref ID J:99881)
  • decreased tail pigmentation
    • display a reduction in pigmentation of the tail   (MGI Ref ID J:99881)
  • respiratory system phenotype
  • abnormal type II pneumocyte morphology
    • progressive cytoplasmic foamy changes are observed in type II pneumocytes from P0 to 24 month of age, increasing in terms of both the affected cell number and degree of severity as mice age   (MGI Ref ID J:110157)
    • marked swelling and degenerative changes of type II pneumocytes (referred to as "giant lamellar body degeneration" or GLBD) in aged mice   (MGI Ref ID J:110157)
    • enlarged alveolar lamellar bodies
      • most lamellar bodies are increased in size at P0   (MGI Ref ID J:110157)
      • numerous giant-sized lamellar bodies are often fused with each other in aged mice   (MGI Ref ID J:110157)
  • alveolitis
    • mild lymphocytic infiltration of the alveolar septa but no fibrosis in some aged mice   (MGI Ref ID J:110157)
  • overexpanded pulmonary alveoli
    • enlarged air spaces in aged mice   (MGI Ref ID J:110157)
  • growth/size/body phenotype
  • decreased ear pigmentation
    • display a reduction in pigmentation of the ears   (MGI Ref ID J:99881)

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

Hps1ep/Hps1ep

        either: C3HeB/FeJ or (involves: C3HeB/FeJ * C57BL/6J)
  • vision/eye phenotype
  • decreased eye pigmentation
    • reduced eye pigment in the first 1-2 days after birth eyes darken with age reduced eye pigment in the first 1-2 days after birth   (MGI Ref ID J:5032)
    • eyes darken with age   (MGI Ref ID J:5032)
  • pigmentation phenotype
  • abnormal melanosome morphology
    • smaller pigment granules reported on this mixed genetic background   (MGI Ref ID J:5032)
  • decreased ear pigmentation
    • light colored ears   (MGI Ref ID J:5032)
  • decreased eye pigmentation
    • reduced eye pigment in the first 1-2 days after birth eyes darken with age reduced eye pigment in the first 1-2 days after birth   (MGI Ref ID J:5032)
    • eyes darken with age   (MGI Ref ID J:5032)
  • decreased tail pigmentation
    • light colored tail   (MGI Ref ID J:5032)
  • diluted coat color
    • paler coat color as juveniles but becoming darker in adults   (MGI Ref ID J:5032)
  • craniofacial phenotype
  • decreased ear pigmentation
    • light colored ears   (MGI Ref ID J:5032)
  • hearing/vestibular/ear phenotype
  • decreased ear pigmentation
    • light colored ears   (MGI Ref ID J:5032)
  • limbs/digits/tail phenotype
  • decreased tail pigmentation
    • light colored tail   (MGI Ref ID J:5032)
  • integument phenotype
  • decreased ear pigmentation
    • light colored ears   (MGI Ref ID J:5032)
  • decreased tail pigmentation
    • light colored tail   (MGI Ref ID J:5032)
  • diluted coat color
    • paler coat color as juveniles but becoming darker in adults   (MGI Ref ID J:5032)
  • growth/size/body phenotype
  • decreased ear pigmentation
    • light colored ears   (MGI Ref ID J:5032)

Hps1ep/Hps1ep

        involves: C3HeB/FeJ * C57BL/6J
  • vision/eye phenotype
  • abnormal choroid pigmentation
    • abnormally large melanosomes in choroidal melanocytes   (MGI Ref ID J:42484)
  • abnormal ciliary body pigmentation
    • reduced   (MGI Ref ID J:6064)
  • abnormal retina morphology
    • reduced pigment in the retina and decreasing in a gradient from the periphery toward the attachment of the optic nerve   (MGI Ref ID J:6064)
  • respiratory system phenotype
  • enlarged alveolar lamellar bodies
    • type II epithelial cells with enlarged lamellar bodies   (MGI Ref ID J:85431)
  • hematopoietic system phenotype
  • abnormal macrophage physiology
    • several fold decrease in secretion of mature beta galactosidase and beta glucuronidase in the presence of ammonium chloride   (MGI Ref ID J:7869)
    • proenzymes are secreted however   (MGI Ref ID J:7869)
  • abnormal platelet dense granule number
    • very few dense bodies in platelets   (MGI Ref ID J:42484)
  • abnormal platelet physiology
    • abnormal platelet aggregation, lower rate   (MGI Ref ID J:42484)
    • decreased ATP release   (MGI Ref ID J:42484)
    • reduced secretion of stored serotonin after thrombin stimulation   (MGI Ref ID J:7327)
    • increased secretion of lysosomal enzymes   (MGI Ref ID J:7327)
  • decreased platelet ADP level
    • ADP levels reduced 2.6-6X   (MGI Ref ID J:7327)
  • decreased platelet ATP level
    • ATP levels reduced 1.4-2X   (MGI Ref ID J:7327)
  • decreased platelet serotonin level
    • 4.5 fold reduction in platelet serotonin   (MGI Ref ID J:7327)
  • homeostasis/metabolism phenotype
  • abnormal circulating enzyme level
    • serum levels of beta glucuronidase and beta galactosidase elevated   (MGI Ref ID J:6219)
  • abnormal platelet physiology
    • abnormal platelet aggregation, lower rate   (MGI Ref ID J:42484)
    • decreased ATP release   (MGI Ref ID J:42484)
    • reduced secretion of stored serotonin after thrombin stimulation   (MGI Ref ID J:7327)
    • increased secretion of lysosomal enzymes   (MGI Ref ID J:7327)
  • abnormal urine homeostasis
    • secretion of lysosomal enzymes in urine is decreased   (MGI Ref ID J:6219)
  • decreased platelet serotonin level
    • 4.5 fold reduction in platelet serotonin   (MGI Ref ID J:7327)
  • increased bleeding time   (MGI Ref ID J:7327)
  • renal/urinary system phenotype
  • abnormal kidney physiology
    • beta glucuronidase, beta galactosidase, and alpha mannosidase elevated in kidneys after testosterone treatment   (MGI Ref ID J:6219)
  • abnormal urine homeostasis
    • secretion of lysosomal enzymes in urine is decreased   (MGI Ref ID J:6219)
  • enlarged kidney
    • hypertrophy as a result of testosterone treatment   (MGI Ref ID J:6219)
  • immune system phenotype
  • abnormal macrophage physiology
    • several fold decrease in secretion of mature beta galactosidase and beta glucuronidase in the presence of ammonium chloride   (MGI Ref ID J:7869)
    • proenzymes are secreted however   (MGI Ref ID J:7869)
  • pigmentation phenotype
  • abnormal choroid pigmentation
    • abnormally large melanosomes in choroidal melanocytes   (MGI Ref ID J:42484)
  • abnormal ciliary body pigmentation
    • reduced   (MGI Ref ID J:6064)
  • abnormal melanosome morphology
    • melanosomes reported to be enlarged in cultured skin melanocytes on this genetic background   (MGI Ref ID J:42484)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Hps1ep related

Dermatology Research
Color and White Spotting Defects

Hematological Research
Platelet Defects
      platelet storage pool deficiency

Internal/Organ Research
Kidney Defects
      lysosomal enzyme abnormalities

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Hps1ep
Allele Name pale-ear
Allele Type Spontaneous
Common Name(s) ep;
Strain of OriginC3HeB/FeJ
Gene Symbol and Name Hps1, Hermansky-Pudlak syndrome 1 homolog (human)
Chromosome 19
Gene Common Name(s) 6030422N11Rik; BB405864; HPS; RIKEN cDNA 6030422N11 gene; ep; expressed sequence BB405864; pale ear;
General Note Genbank ID for mutant allele: AF003867
Molecular Note The underlying mutation responsible for the phenotype in the pale ear mouse was identified as an insertion of an intracisternal A particle in a protein coding- 3' exon of the Hps1 gene. Northern analysis demonstrated qualitative differences in mRNA between wild-type and homozygous mutant animals. [MGI Ref ID J:42484]

Genotyping

Genotyping Information


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Additional References

Lyerla TA; Rusiniak ME; Borchers M; Jahreis G; Tan J; Ohtake P; Novak EK; Swank RT. 2003. Aberrant lung structure, composition, and function in a murine model of Hermansky-Pudlak syndrome. Am J Physiol Lung Cell Mol Physiol 285(3):L643-53. [PubMed: 12777251]  [MGI Ref ID J:85431]

Hps1ep related

Anderson MG; Hawes NL; Trantow CM; Chang B; John SW. 2008. Iris phenotypes and pigment dispersion caused by genes influencing pigmentation. Pigment Cell Melanoma Res 21(5):565-78. [PubMed: 18715234]  [MGI Ref ID J:141035]

Bossi G; Booth S; Clark R; Davis EG; Liesner R; Richards K; Starcevic M; Stinchcombe J; Trambas C; Dell'Angelica EC; Griffiths GM. 2005. Normal lytic granule secretion by cytotoxic T lymphocytes deficient in BLOC-1, -2 and -3 and myosins Va, VIIa and XV. Traffic 6(3):243-51. [PubMed: 15702992]  [MGI Ref ID J:105404]

Brown JA; Novak EK; Swank RT. 1985. Effects of ammonia on processing and secretion of precursor and mature lysosomal enzyme from macrophages of normal and pale ear mice: evidence for two distinct pathways. J Cell Biol 100(6):1894-904. [PubMed: 3922995]  [MGI Ref ID J:7869]

Chiang PW; Oiso N; Gautam R; Suzuki T; Swank RT; Spritz RA. 2003. The Hermansky-Pudlak syndrome 1 (HPS1) and HPS4 proteins are components of two complexes, BLOC-3 and BLOC-4, involved in the biogenesis of lysosome-related organelles. J Biol Chem 278(22):20332-7. [PubMed: 12663659]  [MGI Ref ID J:113973]

Clark EA; Shultz LD; Pollack SB. 1981. Mutations in mice that influence natural killer (NK) cell activity. Immunogenetics 12(5-6):601-13. [PubMed: 6971254]  [MGI Ref ID J:6485]

Feng GH; Bailin T; Oh J; Spritz RA. 1997. Mouse pale ear (ep) is homologous to human Hermansky-Pudlak syndrome and contains a rare 'AT-AC' intron. Hum Mol Genet 6(5):793-7. [PubMed: 9158155]  [MGI Ref ID J:40195]

Feng L; Novak EK; Hartnell LM; Bonifacino JS; Collinson LM; Swank RT. 2002. The Hermansky-Pudlak syndrome 1 (HPS1) and HPS2 genes independently contribute to the production and function of platelet dense granules, melanosomes, and lysosomes. Blood 99(5):1651-8. [PubMed: 11861280]  [MGI Ref ID J:109721]

Gardner JM; Wildenberg SC; Keiper NM; Novak EK; Rusiniak ME; Swank RT ; Puri N ; Finger JN ; Hagiwara N ; Lehman AL ; Gales TL ; Bayer ME ; King RA ; Brilliant MH. 1997. The mouse pale ear (ep) mutation is the homologue of human Hermansky-Pudlak syndrome. Proc Natl Acad Sci U S A 94(17):9238-43. [PubMed: 9256466]  [MGI Ref ID J:42484]

Guttentag SH; Akhtar A; Tao JQ; Atochina E; Rusiniak ME; Swank RT; Bates SR. 2005. Defective surfactant secretion in a mouse model of Hermansky-Pudlak syndrome. Am J Respir Cell Mol Biol 33(1):14-21. [PubMed: 15790974]  [MGI Ref ID J:110954]

Jing R; Dong X; Li K; Zhang J; Yan J; Feng L. 2014. Two distinct phenotypes in pigmented cells of different embryonic origins in eyes of pale ear mice. Exp Eye Res 119:35-43. [PubMed: 24361037]  [MGI Ref ID J:210372]

LaVail JH; Nixon RA; Sidman RL. 1978. Genetic control of retinal ganglion cell projections. J Comp Neurol 182(3):399-421. [PubMed: 102659]  [MGI Ref ID J:6064]

Lane PW; Green EL. 1967. Pale ear and light ear in the house mouse. Mimic mutations in linkage groups XII and XVII. J Hered 58(1):17-20. [PubMed: 6031677]  [MGI Ref ID J:5032]

Lyerla TA; Rusiniak ME; Borchers M; Jahreis G; Tan J; Ohtake P; Novak EK; Swank RT. 2003. Aberrant lung structure, composition, and function in a murine model of Hermansky-Pudlak syndrome. Am J Physiol Lung Cell Mol Physiol 285(3):L643-53. [PubMed: 12777251]  [MGI Ref ID J:85431]

McGarry MP; Novak EK; Swank RT. 1986. Progenitor cell defect correctable by bone marrow transplantation in five independent mouse models of platelet storage pool deficiency. Exp Hematol 14(4):261-5. [PubMed: 3516713]  [MGI Ref ID J:11990]

McGarry MP; Reddington M; Novak EK; Swank RT. 1999. Survival and lung pathology of mouse models of Hermansky-Pudlak syndrome and Chediak-Higashi syndrome. Proc Soc Exp Biol Med 220(3):162-8. [PubMed: 10193444]  [MGI Ref ID J:53228]

Meisler MH; Wanner L; Strahler J. 1984. Pigmentation and lysosomal phenotypes in mice doubly homozygous for both light-ear and pale-ear mutant alleles. J Hered 75(2):103-6. [PubMed: 6232310]  [MGI Ref ID J:7416]

Moore KJ; Swing DA; Copeland NG; Jenkins NA. 1990. Interaction of the murine dilute suppressor gene (dsu) with fourteen coat color mutations [published erratum appears in Genetics 1990 Sep;126(1):285] Genetics 125(2):421-30. [PubMed: 2379821]  [MGI Ref ID J:29467]

Murray HW; Hariprashad J; McDermott DF; Stoeckle MY. 1996. Multiple host defense defects in failure of C57BL/6 ep/ep (pale ear) mice to resolve visceral Leishmania donovani infection. Infect Immun 64(1):161-6. [PubMed: 8557335]  [MGI Ref ID J:30323]

Nazarian R; Falcon-Perez JM; Dell'Angelica EC. 2003. Biogenesis of lysosome-related organelles complex 3 (BLOC-3): a complex containing the Hermansky-Pudlak syndrome (HPS) proteins HPS1 and HPS4. Proc Natl Acad Sci U S A 100(15):8770-5. [PubMed: 12847290]  [MGI Ref ID J:99881]

Nguyen T; Novak EK; Kermani M; Fluhr J; Peters LL; Swank RT; Wei ML. 2002. Melanosome morphologies in murine models of hermansky-pudlak syndrome reflect blocks in organelle development. J Invest Dermatol 119(5):1156-64. [PubMed: 12445206]  [MGI Ref ID J:80751]

Nguyen T; Wei ML. 2007. Hermansky-Pudlak HPS1/pale ear gene regulates epidermal and dermal melanocyte development. J Invest Dermatol 127(2):421-8. [PubMed: 17068483]  [MGI Ref ID J:117715]

Novak EK; Hui SW; Swank RT. 1984. Platelet storage pool deficiency in mouse pigment mutations associated with seven distinct genetic loci. Blood 63(3):536-44. [PubMed: 6696991]  [MGI Ref ID J:7327]

Novak EK; Hui SW; Swank RT. 1981. The mouse pale ear pigment mutant as a possible animal model for human platelet storage pool deficiency. Blood 57(1):38-43. [PubMed: 7448413]  [MGI Ref ID J:6448]

Novak EK; Swank RT. 1979. Lysosomal dysfunctions associated with mutations at mouse pigment genes. Genetics 92(1):189-204. [PubMed: 115747]  [MGI Ref ID J:6219]

Orn A; Hakansson EM; Gidlund M; Ramstedt U; Axberg I; Wigzell H; Lundin LG. 1982. Pigment mutations in the mouse which also affect lysosomal functions lead to suppressed natural killer cell activity. Scand J Immunol 15(3):305-10. [PubMed: 7089489]  [MGI Ref ID J:6801]

Paigen B; Holmes PA; Novak EK; Swank RT. 1990. Analysis of atherosclerosis susceptibility in mice with genetic defects in platelet function. Arteriosclerosis 10(4):648-52. [PubMed: 2369371]  [MGI Ref ID J:29748]

Salazar G; Craige B; Styers ML; Newell-Litwa KA; Doucette MM; Wainer BH; Falcon-Perez JM; Dell'Angelica EC; Peden AA; Werner E; Faundez V. 2006. BLOC-1 complex deficiency alters the targeting of adaptor protein complex-3 cargoes. Mol Biol Cell 17(9):4014-26. [PubMed: 16760431]  [MGI Ref ID J:114481]

Silvers WK. 1979. The Coat Colors of Mice; A Model for Mammalian Gene Action and Interaction. In: The Coat Colors of Mice. Springer-Verlag, New York.  [MGI Ref ID J:78801]

Swank RT; Novak EK; McGarry MP; Zhang Y; Li W; Zhang Q; Feng L. 2000. Abnormal vesicular trafficking in mouse models of Hermansky-Pudlak syndrome. Pigment Cell Res 13 Suppl 8:59-67. [PubMed: 11041359]  [MGI Ref ID J:103794]

Tang X; Yamanaka S; Miyagi Y; Nagashima Y; Nakatani Y. 2005. Lung pathology of pale ear mouse (model of Hermansky-Pudlak syndrome 1) and beige mouse (model of Chediak-Higashi syndrome): severity of giant lamellar body degeneration of type II pneumocytes correlates with interstitial inflammation. Pathol Int 55(3):137-43. [PubMed: 15743322]  [MGI Ref ID J:110157]

Wei AH; Zang DJ; Zhang Z; Liu XZ; He X; Yang L; Wang Y; Zhou ZY; Zhang MR; Dai LL; Yang XM; Li W. 2013. Exome Sequencing Identifies SLC24A5 as a Candidate Gene for Nonsyndromic Oculocutaneous Albinism. J Invest Dermatol 133(7):1834-40. [PubMed: 23364476]  [MGI Ref ID J:198009]

Xie T; Nguyen T; Hupe M; Wei ML. 2009. Multidrug resistance decreases with mutations of melanosomal regulatory genes. Cancer Res 69(3):992-9. [PubMed: 19155314]  [MGI Ref ID J:144973]

Young LR; Borchers MT; Allen HL; Gibbons RS; McCormack FX. 2006. Lung-restricted macrophage activation in the pearl mouse model of Hermansky-Pudlak syndrome. J Immunol 176(7):4361-8. [PubMed: 16547274]  [MGI Ref ID J:129894]

Young LR; Pasula R; Gulleman PM; Deutsch GH; McCormack FX. 2007. Susceptibility of Hermansky-Pudlak mice to bleomycin-induced type II cell apoptosis and fibrosis. Am J Respir Cell Mol Biol 37(1):67-74. [PubMed: 17363777]  [MGI Ref ID J:137563]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $3300.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $4290.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


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