Strain Name:

B6.C-Fgf5go/J

Stock Number:

000526

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Availability:

Cryopreserved - Ready for recovery

Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Type Congenic; Mutant Strain;
Additional information on Genetically Engineered and Mutant Mice.
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Additional information on Congenic nomenclature.
Specieslaboratory mouse
GenerationN13
Generation Definitions

Description
Mice homozygous for Fgf5go, the angora allele, have a prolonged anagen VI phase of the hair follicle cycle resulting in hair lengths that are longer than normal for all coat hair types. These mice begin to appear shaggy by 15-21 days of age and remain so throughout their lives. Fgf5go/Fgf5go skin grafts continue to yield long fur but do not alter the fur growth in surrounding host tissue indicating that FGF5 does not function in a systemic manner but rather must be produced in the follicle in which it has an effect. A subtle follicular dystrophy has been described in mice on the B6.C congenic background (See Sundberg et al., 1997). (Dickie MM, 1966; Pennycuik and Raphael, 1984.)

Related Strains

Strains carrying   Fgf5go allele
000795   B6By.C-H52 Fgf5go/J
View Strains carrying   Fgf5go     (1 strain)

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested.
Trichomegaly; TCMGLY   (FGF5)
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

Fgf5go/Fgf5go

        involves: BALB/cJ
  • integument phenotype
  • abnormal coat/ hair morphology   (MGI Ref ID J:13413)
    • abnormal auchene hair morphology
      • the proximal segment is longer   (MGI Ref ID J:100288)
    • abnormal hair growth
      • all hairtypes are significantly longer   (MGI Ref ID J:100288)
      • coat guard hairs show greatest increase in length   (MGI Ref ID J:100288)
      • juvenile and the adult coats are affected   (MGI Ref ID J:13413)
      • evident beginning about 18 days old by the extra length of guard hairs   (MGI Ref ID J:13413)
      • dermal-epidermal recombination grafts show the mutation is due to abnormalities in the epidermis   (MGI Ref ID J:13413)
      • long hair   (MGI Ref ID J:13413)
    • abnormal zigzag hair morphology
      • there are four rather than three segments   (MGI Ref ID J:100288)
      • each of the three distal segments is longer   (MGI Ref ID J:100288)
    • increased guard hair length
      • show greatest increase in length   (MGI Ref ID J:100288)
      • at weaning the guard hairs are more than twice normal length   (MGI Ref ID J:13413)
  • abnormal hair cycle
    • age of eruption of the second hair coat in females was slightly delayed   (MGI Ref ID J:100288)
    • the entire hair cycle is 2 to 3 days longer than normal due to an increase in the anagen phase   (MGI Ref ID J:100288)
  • increased vibrissae length   (MGI Ref ID J:13413)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Fgf5go related

Dermatology Research
Skin and Hair Texture Defects

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Fgf5go
Allele Name angora
Allele Type Spontaneous
Common Name(s) FGF-5-; go;
Strain of OriginBALB/cJ
Gene Symbol and Name Fgf5, fibroblast growth factor 5
Chromosome 5
Gene Common Name(s) Fgf-5; HBGF-5; Smag-82; TCMGLY; angora; go;
Molecular Note Sequences encoding exon 1 are deleted in this mutation. The deletion extends at least 2 kb 5' to the translation start site. Expression of Fgf5 in hair follicles of wild-type mice is localized to the outer root sheath during the hair production phase ofthe follicle cycle. FGF5 may function as an inhibitor of hair elongation. [MGI Ref ID J:20551]

Genotyping

Genotyping Information


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Additional References

Hebert JM; Rosenquist T; Gotz J; Martin GR. 1994. FGF5 as a regulator of the hair growth cycle: evidence from targeted and spontaneous mutations. Cell 78(6):1017-25. [PubMed: 7923352]  [MGI Ref ID J:20551]

Ozawa K; Suzuki S; Asada M; Tomooka Y; Li AJ; Yoneda A; Komi A; Imamura T. 1998. An alternatively spliced fibroblast growth factor (FGF)-5 mRNA is abundant in brain and translates into a partial agonist/antagonist for FGF-5 neurotrophic activity. J Biol Chem 273(44):29262-71. [PubMed: 9786939]  [MGI Ref ID J:50598]

Reuss B; Dono R; Unsicker K. 2003. Functions of fibroblast growth factor (FGF)-2 and FGF-5 in astroglial differentiation and blood-brain barrier permeability: evidence from mouse mutants. J Neurosci 23(16):6404-12. [PubMed: 12878680]  [MGI Ref ID J:84705]

Sundberg JP; Rourk MH; Boggess D; Hogan ME; Sundberg BA; Bertolino AP. 1997. Angora mouse mutation: altered hair cycle, follicular dystrophy, phenotypic maintenance of skin grafts, and changes in keratin expression. Vet Pathol 34(3):171-9. [PubMed: 9163872]  [MGI Ref ID J:41155]

Fgf5go related

Cho YM; Woodard GL; Dunbar M; Gocken T; Jimenez JA; Foley J. 2003. Hair-cycle-dependent expression of parathyroid hormone-related protein and its type I receptor: evidence for regulation at the anagen to catagen transition. J Invest Dermatol 120(5):715-27. [PubMed: 12713572]  [MGI Ref ID J:83352]

Dickie MM. 1963. Angora Mouse News Lett 29:39.  [MGI Ref ID J:13413]

Hebert JM; Rosenquist T; Gotz J; Martin GR. 1994. FGF5 as a regulator of the hair growth cycle: evidence from targeted and spontaneous mutations. Cell 78(6):1017-25. [PubMed: 7923352]  [MGI Ref ID J:20551]

Hogan ME; King LE Jr; Sundberg JP. 1995. Defects of pelage hairs in 20 mouse mutations. J Invest Dermatol 104(5 Suppl):31S-32S. [PubMed: 7738386]  [MGI Ref ID J:25255]

Ma L; Liu J; Wu T; Plikus M; Jiang TX; Bi Q; Liu YH; Muller-Rover S; Peters H; Sundberg JP; Maxson R; Maas RL; Chuong CM. 2003. 'Cyclic alopecia' in Msx2 mutants: defects in hair cycling and hair shaft differentiation. Development 130(2):379-89. [PubMed: 12466204]  [MGI Ref ID J:80585]

McGeachie AB; Koishi K; Imamura T; McLennan IS. 2001. Fibroblast growth factor-5 is expressed in Schwann cells and is not essential for motoneurone survival. Neuroscience 104(3):891-9. [PubMed: 11440818]  [MGI Ref ID J:85910]

Moscoso LM; Cremer H; Sanes JR. 1998. Organization and reorganization of neuromuscular junctions in mice lacking neural cell adhesion molecule, tenascin-C, or fibroblast growth factor-5. J Neurosci 18(4):1465-77. [PubMed: 9454855]  [MGI Ref ID J:45762]

Pennycuik PR; Raphael KA. 1984. The angora locus (go) in the mouse: hair morphology, duration of growth cycle and site of action. Genet Res 44(3):283-91. [PubMed: 6397398]  [MGI Ref ID J:100288]

Sundberg JP (ed.). 1994. Handbook of Mouse Mutations with Skin and Hair Abnormalities: Animal Models and Biomedical Tools. In: Handbook of Mouse Mutations with Skin and Hair Abnormalities: Animal Models and Biomedical Tools. CRC Press, Boca Raton.  [MGI Ref ID J:30359]

Sundberg JP; Rourk MH; Boggess D; Hogan ME; Sundberg BA; Bertolino AP. 1997. Angora mouse mutation: altered hair cycle, follicular dystrophy, phenotypic maintenance of skin grafts, and changes in keratin expression. Vet Pathol 34(3):171-9. [PubMed: 9163872]  [MGI Ref ID J:41155]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $3300.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $4290.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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