Description

Strain Information

Former Names C57BL/6J-Otx1jv/+    (Changed: 15-DEC-04 ) C57BL/6J-jv/+    (Changed: 15-DEC-04 ) Type Coisogenic; Mutant Strain; Spontaneous Mutation; Additional information on Genetically Engineered Mutant Mice. Species laboratory mouse H2 Haplotype b Generation [F26N1p]+N2F3 (06-DEC-07)

Appearance
black, affected
Related Genotype: a/a Otx1^jv/Otx1^jv

black, unaffected
Related Genotype: a/a Otx1^jv/+

Description
Mice homozygous for the Jackson waltzer mutation run in circles and shake their heads. The lateral semicircular canal and its cristae are absent, and the sacculus and utriculus may be morphologically abnormal. However, hearing is unaffected. This pheontype is similar to that reported for the Otx1^tm1Asim targeted mutation and complementation testing with this targeted mutation showed jv to be an allele of Otx1. (Note that C57BL/6J is homozygous for ahl, the age related hearing loss 1 mutation, which on this strain background causes progressive hearing loss with onset after 10 months of age.) Homozygotes can swim.

Development
The Jackson waltzer (Otx1^jv) mutation arose on the C57BL/6J inbred strain at The Jackson Laboratory in 1961. It has been maintained on the same background.

Control Information

	Control
	Heterozygote from the colony
Considerations for Choosing Controls

Related Strains

Strains carrying other alleles of Otx1

005697

B6.129-Otx1tm4(cre)Asim/J

View Strains carrying other alleles of Otx1     (1 strain)

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms

      assigned by genotype

Otx1^jv/Otx1^jv

        C57BL/6J-Otx1^jv/J

• behavior/neurological phenotype
• circling (MGI Ref ID J:86284)
  • although circling behavior is indicitive of a hearing defect, animals are not deaf
• head shaking (MGI Ref ID J:13457)
• hearing/vestibular/ear phenotype
• *normal* hearing/vestibular/ear phenotype (MGI Ref ID J:86284)
  • normal ABR thresholds are measured at 6-8 weeks of age and again at 20-28 weeks of age, suggesting normal cochlear function and normal hearing
• abnormal saccule morphology (MGI Ref ID J:13457)
  • abnormal morphogenesis
• abnormal utricle morphology (MGI Ref ID J:13457)
  • abnormal morphogenesis
• absent lateral semicircular canal (MGI Ref ID J:86284)
  • the associated cristae are also absent
• circling (MGI Ref ID J:86284)
  • although circling behavior is indicitive of a hearing defect, animals are not deaf
• head shaking (MGI Ref ID J:13457)

View Research Applications

Research Applications

This mouse can be used to support research in many areas including:

Otx1^jv related

Neurobiology Research
Vestibular and Hearing Defects

Sensorineural Research
Vestibular and Hearing Defects

Genes & Alleles

Gene & Allele Information

Allele Symbol		Otx1jv
Allele Name		Jackson waltzer
Allele Type		Spontaneous
Common Name(s)		jv;
Strain of Origin		C57BL/6J
Gene Symbol and Name		Otx1, orthodenticle homolog 1 (Drosophila)
Chromosome		11
Gene Common Name(s)		A730044F23Rik; FLJ38361; Jackson waltzer; MGC15736; OTX1X; RIKEN cDNA A730044F23 gene; jv;
Molecular Note		Jackson Waltzer was found to be an allele at the Otx1 locus through complementation testing with Otx1tm1Asim. [MGI Ref ID J:86284]

Genotyping

Genotyping Information

This strain will not have a genotyping protocol or one is not currently available.

Helpful Links

Optimizing PCR Protocols

References

References

Selected Reference(s)

Cook SA; Gray SJ; Johnson KR; Davisson MT. 2003. Jackson waltzer (jv) is an allele of Otx1. Mouse Mutant Resources Web Site, The Jackson Laboratory, Bar Harbor, Maine (http://www.jax.org/mmr) MGI Direct Data Submission :.  [MGI Ref ID J:86284]

Additional References

Otx1^jv related

Dickie MM; Deol MS. 1966. [Jackson waltzer, jv.] Mouse News Lett 35:31.  [MGI Ref ID J:13457]

Jones SM; Johnson KR; Yu H; Erway LC; Alagramam KN; Pollak N; Jones TA. 2005. A quantitative survey of gravity receptor function in mutant mouse strains. J Assoc Res Otolaryngol 6(4):297-310. [PubMed: 16235133]  [MGI Ref ID J:116914]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           A1

Purchasing information

Pricing, Supply Level & Notes, Controls, General Terms & Conditions

Pricing

Supply Details

Standard Supply

Repository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of ~nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within 48 hours of order placement.

Supply Notes

Usually shipped between four and eight weeks of age. This strain is included in the Mouse Mutant Resource collection.

Control Information

	Control
	Heterozygote from the colony
Considerations for Choosing Controls
USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains.
International - Control Pricing Information for Genetically Engineered Mutant Strains.

General Terms and Conditions

See Terms of Use

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

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Ordering and Purchasing Information

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Terms of Use

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Contact information

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