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Former Names B6EiC3 a/A-deH/J (Changed: 15-DEC-04 ) Type Mutant Strain; Spontaneous Mutation; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Species laboratory mouse Generation N3F2N1p
Generation Definitions
Strains carrying a allele
View Strains carrying a (103 strains)
Strains carrying other alleles of a
View Strains carrying other alleles of a (178 strains)
View Mammalian Phenotype Terms
Mammalian Phenotype Terms
assigned by genotype
Tbx15de-H/Tbx15de-H
B6EiC3 a/A-Tbx15de-H/J
- skeleton phenotype
- abnormal basioccipital bone morphology
- narrow basioccipital bone (MGI Ref ID J:101708)
- abnormal cervical atlas morphology
- ectopic cartilage, including at this stage a tiny ossification center, is present at a corresponding position in the atlas (MGI Ref ID J:101708)
- abnormal cervical axis morphology
- the dens of axis is reduced (MGI Ref ID J:101708)
- abnormal mandible morphology
- in the lower jaw, the dentaries are shorter, with a short angular process (MGI Ref ID J:101708)
- abnormal pectoral girdle morphology
- abnormal pectoral girdle (MGI Ref ID J:101708)
- abnormal acromion morphology
- the acromion is reduced at E16.5 (MGI Ref ID J:101708)
- scapular bone foramen
- 100% penetrance (MGI Ref ID J:101708)
- small scapula
- scapula is reduced in size and is more posteriorly and ventrally positioned at E13.5 (MGI Ref ID J:101708)
- abnormal vertebral arch morphology
- neural arches exhibit various abnormalities, including an axis with widened arches along the anteroposterior direction (MGI Ref ID J:101708)
- decreased skull width
- skull is narrower (MGI Ref ID J:101708)
- longitudinally short skull (MGI Ref ID J:101708)
- craniofacial phenotype
- abnormal basioccipital bone morphology
- narrow basioccipital bone (MGI Ref ID J:101708)
- abnormal ear distance/ position
- abnormal position of the ears (MGI Ref ID J:101708)
- abnormal mandible morphology
- in the lower jaw, the dentaries are shorter, with a short angular process (MGI Ref ID J:101708)
- decreased skull width
- skull is narrower (MGI Ref ID J:101708)
- longitudinally short skull (MGI Ref ID J:101708)
- hearing/vestibular/ear phenotype
- abnormal ear distance/ position
- abnormal position of the ears (MGI Ref ID J:101708)
The following phenotype relates to a compound genotype created using this strain.
Contact JAX® Services jaxservices@jax.org for customized breeding options.at/at Tbx15de-H/Tbx15de-H
involves: BTBR * C3H/HeJ * C57BL/6
- pigmentation phenotype
- abnormal dorsoventral coat patterning
- the thin stripe of yellow hair that normally separates the dorsal black hairs from the ventral cream hairs in at mice is extended dorsally and the boundary between the yellow and the black hairs is fuzzier (MGI Ref ID J:87455)
- abnormal ventral coat pigmentation
- resembles pattern of a black-and-tan (at) mutation (MGI Ref ID J:87455)
- irregular coat pigmentation
- abnormal dorsoventral pigment patterning with proportion of body circumference occupied by the lateral region increased 2-fold over normal patterning and the proportion of the ventral cream-colored region expanding a small amount, 47.9% compared to 37.8% in at (MGI Ref ID J:87455)
- craniofacial phenotype
- broad nasal bridge (MGI Ref ID J:87455)
- lowered ear position (MGI Ref ID J:87455)
- shortened head
- elevated skull contributes lowered ear position with pinnae projecting laterally (MGI Ref ID J:87455)
- skin/coat/nails phenotype
- abnormal dorsoventral coat patterning
- the thin stripe of yellow hair that normally separates the dorsal black hairs from the ventral cream hairs in at mice is extended dorsally and the boundary between the yellow and the black hairs is fuzzier (MGI Ref ID J:87455)
- abnormal ventral coat pigmentation
- resembles pattern of a black-and-tan (at) mutation (MGI Ref ID J:87455)
- irregular coat pigmentation
- abnormal dorsoventral pigment patterning with proportion of body circumference occupied by the lateral region increased 2-fold over normal patterning and the proportion of the ventral cream-colored region expanding a small amount, 47.9% compared to 37.8% in at (MGI Ref ID J:87455)
- vision/eye phenotype
- abnormal eyelid morphology
- small palpebral fissures noted (MGI Ref ID J:87455)
- ocular hypertelorism
- results in widely spaced eyes (MGI Ref ID J:87455)
- growth/size phenotype
- decreased body size (MGI Ref ID J:87455)
- hearing/vestibular/ear phenotype
- lowered ear position (MGI Ref ID J:87455)
View Research Applications
Research Applications
This mouse can be used to support research in many areas including:Tbx15de-H related
Developmental Biology Research
Skeletal Defects
Neurobiology Research
Vestibular and Hearing Defects
Sensorineural Research
Vestibular and Hearing Defects
| Allele Symbol | Tbx15de-H | ||
|---|---|---|---|
| Allele Name | droopy ear Harwell | ||
| Allele Type | Not Specified | ||
| Common Name(s) | Tbx14; Tbx8; | ||
| Gene Symbol and Name | Tbx15, T-box 15 | ||
| Chromosome | 3 | ||
| Gene Common Name(s) | T-box 14; TBX14; Tbx14; Tbx8; de; droopy ear; | ||
| Molecular Note | By comparing the sequence of a 1.3kb junction fragment amplified from a homozygous mutant to a public genome sequence, this allele was found to comprise a 216 kb deletion that extends from intron 1 to 148 kb downstream of the polyadenylation sequence, removing all but the first exon of the Tbx15 gene. | ||
| Allele Symbol | a | ||
| Allele Name | nonagouti | ||
| Allele Type | Spontaneous | ||
This strain will not have a genotyping protocol or one is not currently available.Helpful Links
Genotyping resources and troubleshooting
Tbx15de-H relatedCandille SI; Raamsdonk CD; Chen C; Kuijper S; Chen-Tsai Y; Russ A; Meijlink F; Barsh GS. 2004. Dorsoventral patterning of the mouse coat by tbx15. PLoS Biol 2(1):E3. [PubMed: 14737183] [MGI Ref ID J:87455]
Curry GA. 1959. Genetical and development studies on droopy-eared mice. J Embryol Exp Morphol 7(1):39-65. [PubMed: 13654621] [MGI Ref ID J:233]
Kuijper S; Beverdam A; Kroon C; Brouwer A; Candille S; Barsh G; Meijlink F. 2005. Genetics of shoulder girdle formation: roles of Tbx15 and aristaless-like genes. Development 132(7):1601-10. [PubMed: 15728667] [MGI Ref ID J:101708]
Currently there is no information available for this strain. This may be due to the supply level of this strain.
| Pricing for USA, Canada and Mexico shipping destinations |
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Cryopreserved Mice - Ready for Recovery
Animals Provided
Price (US dollars $) Cryorecovery* $1900.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Standard Supply
Cryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information.
Supply Notes
- Cryorecovery - Standard.
We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. The total number of animals provided, their gender and genotype will vary. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 13 and 16 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).
| Pricing for International shipping destinations |
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Cryopreserved Mice - Ready for Recovery
Animals Provided
Price (US dollars $) Cryorecovery* $2470.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Standard Supply
Cryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information.
Supply Notes
- Cryorecovery - Standard.
We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. The total number of animals provided, their gender and genotype will vary. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 13 and 16 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).
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Cryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information.
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Contact Information
Orders & Technical Support
Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
Technical Support Email Form
| phone: | 207-288-6470 |
| fax: | 207-288-6655 |
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