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Former Names B6EiC3 a/A-deH/J (Changed: 15-DEC-04 ) Type Mutant Strain; Spontaneous Mutation; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Species laboratory mouse Generation N3F2N1p
Strains carrying a allele
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Strains carrying other alleles of a
View Strains carrying other alleles of a (81 strains)
View Mammalian Phenotype Terms
Mammalian Phenotype Terms
assigned by genotype
Tbx15de-H/Tbx15de-H
B6EiC3 a/A-Tbx15de-H/J
- skeleton phenotype
- abnormal basioccipital bone morphology (MGI Ref ID J:101708)
- narrow basioccipital bone
- abnormal cervical atlas morphology (MGI Ref ID J:101708)
- ectopic cartilage, including at this stage a tiny ossification center, is present at a corresponding position in the atlas
- abnormal cervical axis morphology (MGI Ref ID J:101708)
- the dens of axis is reduced
- abnormal mandible morphology (MGI Ref ID J:101708)
- in the lower jaw, the dentaries are shorter, with a short angular process
- abnormal shoulder bone morphology (MGI Ref ID J:101708)
- abnormal pectoral girdle
- abnormal acromion morphology (MGI Ref ID J:101708)
- the acromion is reduced at E16.5
- scapular bone foramen (MGI Ref ID J:101708)
- 100% penetrance
- small scapula (MGI Ref ID J:101708)
- scapula is reduced in size and is more posteriorly and ventrally positioned at E13.5
- abnormal vertebral arch morphology (MGI Ref ID J:101708)
- neural arches exhibit various abnormalities, including an axis with widened arches along the anteroposterior direction
- decreased skull width (MGI Ref ID J:101708)
- skull is narrower
- longitudinally short skull (MGI Ref ID J:101708)
- craniofacial phenotype
- abnormal basioccipital bone morphology (MGI Ref ID J:101708)
- narrow basioccipital bone
- abnormal ear distance/ position (MGI Ref ID J:101708)
- abnormal position of the ears
- abnormal mandible morphology (MGI Ref ID J:101708)
- in the lower jaw, the dentaries are shorter, with a short angular process
- decreased skull width (MGI Ref ID J:101708)
- skull is narrower
- longitudinally short skull (MGI Ref ID J:101708)
- hearing/vestibular/ear phenotype
- abnormal ear distance/ position (MGI Ref ID J:101708)
- abnormal position of the ears
The following phenotype relates to a compound genotype created using this strain.
Contact JAX® Services jaxservices@jax.org for customized breeding options.at/at Tbx15de-H/Tbx15de-H
involves: BTBR * C3H/HeJ * C57BL/6
- pigmentation phenotype
- abnormal dorsoventral coat patterning (MGI Ref ID J:87455)
- the thin stripe of yellow hair that normally separates the dorsal black hairs from the ventral cream hairs in at mice is extended dorsally and the boundary between the yellow and the black hairs is fuzzier
- abnormal ventral coat pigmentation (MGI Ref ID J:87455)
- resembles pattern of a black-and-tan (at) mutation
- irregular coat pigmentation (MGI Ref ID J:87455)
- abnormal dorsoventral pigment patterning with proportion of body circumference occupied by the lateral region increased 2-fold over normal patterning and the proportion of the ventral cream-colored region expanding a small amount, 47.9% compared to 37.8% in at
- craniofacial phenotype
- broad nasal bridge (MGI Ref ID J:87455)
- lowered ear position (MGI Ref ID J:87455)
- shortened head (MGI Ref ID J:87455)
- elevated skull contributes lowered ear position with pinnae projecting laterally
- skin/coat/nails phenotype
- abnormal dorsoventral coat patterning (MGI Ref ID J:87455)
- the thin stripe of yellow hair that normally separates the dorsal black hairs from the ventral cream hairs in at mice is extended dorsally and the boundary between the yellow and the black hairs is fuzzier
- abnormal ventral coat pigmentation (MGI Ref ID J:87455)
- resembles pattern of a black-and-tan (at) mutation
- irregular coat pigmentation (MGI Ref ID J:87455)
- abnormal dorsoventral pigment patterning with proportion of body circumference occupied by the lateral region increased 2-fold over normal patterning and the proportion of the ventral cream-colored region expanding a small amount, 47.9% compared to 37.8% in at
- vision/eye phenotype
- abnormal eyelid morphology (MGI Ref ID J:87455)
- small palpebral fissures noted
- ocular hypertelorism (MGI Ref ID J:87455)
- results in widely spaced eyes
- growth/size phenotype
- decreased body size (MGI Ref ID J:87455)
- hearing/vestibular/ear phenotype
- lowered ear position (MGI Ref ID J:87455)
View Research Applications
Research Applications
This mouse can be used to support research in many areas including:Tbx15de-H related
Developmental Biology Research
Skeletal Defects
Neurobiology Research
Vestibular and Hearing Defects
Sensorineural Research
Vestibular and Hearing Defects
| Allele Symbol | Tbx15de-H | ||
|---|---|---|---|
| Allele Name | droopy ear Harwell | ||
| Allele Type | Not Specified | ||
| Common Name(s) | Tbx14; Tbx8; | ||
| Gene Symbol and Name | Tbx15, T-box 15 | ||
| Chromosome | 3 | ||
| Gene Common Name(s) | T-box 14; TBX14; Tbx14; Tbx8; de; droopy ear; | ||
| Molecular Note | By comparing the sequence of a 1.3kb junction fragment amplified from a homozygous mutant to a public genome sequence, this allele was found to comprise a 216 kb deletion that extends from intron 1 to 148 kb downstream of the polyadenylation sequence, removing all but the first exon of the Tbx15 gene. | ||
| Allele Symbol | a | ||
| Allele Name | nonagouti | ||
| Allele Type | Spontaneous | ||
This strain will not have a genotyping protocol or one is not currently available.
Helpful Links
Genotyping resources and troubleshooting
Tbx15de-H relatedCandille SI; Raamsdonk CD; Chen C; Kuijper S; Chen-Tsai Y; Russ A; Meijlink F; Barsh GS. 2004. Dorsoventral patterning of the mouse coat by tbx15. PLoS Biol 2(1):E3. [PubMed: 14737183] [MGI Ref ID J:87455]
Curry GA. 1959. Genetical and development studies on droopy-eared mice. J Embryol Exp Morphol 7(1):39-65. [PubMed: 13654621] [MGI Ref ID J:233]
Kuijper S; Beverdam A; Kroon C; Brouwer A; Candille S; Barsh G; Meijlink F. 2005. Genetics of shoulder girdle formation: roles of Tbx15 and aristaless-like genes. Development 132(7):1601-10. [PubMed: 15728667] [MGI Ref ID J:101708]
Currently there no information available for this strain. This may be due to the supply level of this strain.
| Pricing for USA, Canada and Mexico shipping destinations |
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Animals Provided
Price (US dollars $) Cryorecovery Fee $1900.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
| Pricing for International shipping destinations |
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Animals Provided
Price (US dollars $) Cryorecovery Fee $2470.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
| Standard Supply | Cryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information. |
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| Supply Notes |
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Purchasing Information
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Contact Information
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Technical Support Email Form
| phone: | 207-288-6470 |
| fax: | 207-288-6655 |
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