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Strain Name: |
B6EiC3 a/A-Tbx15de-H/J |
Stock Number: |
000551 |
Availability:
| Repository-Cryopreserved |
| Former Name |
B6EiC3 a/A-deH/J (Changed: 15-DEC-04
)
|
| Genes & Alleles |
Tbx15;
Tbx15de-H;
a;
|
Product Information
Strain Details
| Type |
JAX® GEMM® Strain -
Mutant Strain |
| Additional information on
JAX® GEMM® Strains. |
| Type |
JAX® GEMM® Strain -
Spontaneous Mutation |
| Species | laboratory mouse |
| Generation | N3F2N1p
|
|
|
Mammalian Phenotype Terms assigned by genotype
Tbx15de-H/Tbx15de-H
B6EiC3 a/A-Tbx15de-H/J
- skeleton phenotype
- abnormal basioccipital bone morphology
(MGI Ref ID J:101708)
- narrow basioccipital bone
- abnormal cervical atlas morphology
(MGI Ref ID J:101708)
- ectopic cartilage, including at this stage a tiny ossification center, is present at a corresponding position in the atlas
- abnormal cervical axis morphology
(MGI Ref ID J:101708)
- the dens of axis is reduced
- abnormal mandible morphology
(MGI Ref ID J:101708)
- in the lower jaw, the dentaries are shorter, with a short angular process
- abnormal shoulder bone morphology
(MGI Ref ID J:101708)
- abnormal acromion morphology
(MGI Ref ID J:101708)
- the acromion is reduced at E16.5
- scapular bone foramen
(MGI Ref ID J:101708)
- small scapula
(MGI Ref ID J:101708)
- scapula is reduced in size and is more posteriorly and ventrally positioned at E13.5
- abnormal vertebral arch morphology
(MGI Ref ID J:101708)
- neural arches exhibit various abnormalities, including an axis with widened arches along the anteroposterior direction
- decreased skull width
(MGI Ref ID J:101708)
- longitudinally short skull
(MGI Ref ID J:101708)
- craniofacial phenotype
- abnormal basioccipital bone morphology
(MGI Ref ID J:101708)
- narrow basioccipital bone
- abnormal ear distance/ position
(MGI Ref ID J:101708)
- abnormal position of the ears
- abnormal mandible morphology
(MGI Ref ID J:101708)
- in the lower jaw, the dentaries are shorter, with a short angular process
- decreased skull width
(MGI Ref ID J:101708)
- longitudinally short skull
(MGI Ref ID J:101708)
- hearing/vestibular/ear phenotype
- abnormal ear distance/ position
(MGI Ref ID J:101708)
- abnormal position of the ears
The following phenotype relates to a compound genotype created using this strain. Contact JAX® Services jaxservices@jax.org for customized breeding options.
at/at Tbx15de-H/Tbx15de-H
involves: BTBR * C3H/HeJ * C57BL/6
- pigmentation phenotype
- abnormal dorsoventral coat patterning
(MGI Ref ID J:87455)
- the thin stripe of yellow hair that normally separates the dorsal black hairs from the ventral cream hairs in at mice is extended dorsally and the boundary between the yellow and the black hairs is fuzzier
- abnormal ventral coat pigmentation
(MGI Ref ID J:87455)
- resembles pattern of a black-and-tan (at) mutation
- irregular coat pigmentation
(MGI Ref ID J:87455)
- abnormal dorsoventral pigment patterning with proportion of body circumference occupied by the lateral region increased 2-fold over normal patterning and the proportion of the ventral cream-colored region expanding a small amount, 47.9% compared to 37.8% in at
- craniofacial phenotype
- broad nasal bridge
(MGI Ref ID J:87455)
- lowered ear position
(MGI Ref ID J:87455)
- shortened head
(MGI Ref ID J:87455)
- elevated skull contributes lowered ear position with pinnae projecting laterally
- skin/coat/nails phenotype
- abnormal dorsoventral coat patterning
(MGI Ref ID J:87455)
- the thin stripe of yellow hair that normally separates the dorsal black hairs from the ventral cream hairs in at mice is extended dorsally and the boundary between the yellow and the black hairs is fuzzier
- abnormal ventral coat pigmentation
(MGI Ref ID J:87455)
- resembles pattern of a black-and-tan (at) mutation
- irregular coat pigmentation
(MGI Ref ID J:87455)
- abnormal dorsoventral pigment patterning with proportion of body circumference occupied by the lateral region increased 2-fold over normal patterning and the proportion of the ventral cream-colored region expanding a small amount, 47.9% compared to 37.8% in at
- vision/eye phenotype
- abnormal eyelid morphology
(MGI Ref ID J:87455)
- small palpebral fissures noted
- ocular hypertelorism
(MGI Ref ID J:87455)
- results in widely spaced eyes
- growth/size phenotype
- decreased body size
(MGI Ref ID J:87455)
- hearing/vestibular/ear phenotype
- lowered ear position
(MGI Ref ID J:87455)
|
Gene & Allele Details
| Allele Symbol |
Tbx15de-H |
| Allele Name |
droopy ear Harwell |
| Common Name(s) |
Tbx14;
Tbx8;
|
| Gene Symbol and Name |
Tbx15, T-box 15 |
| Chromosome |
3 |
| Gene Common Name(s) |
T-box 14;
TBX14;
Tbx14;
Tbx8;
de;
droopy ear;
|
| Molecular Note |
By comparing the sequence of a 1.3kb junction fragment amplified from a homozygous mutant to a public genome sequence, this allele was found to comprise a 216 kb deletion that extends from intron 1 to 148 kb downstream of the polyadenylation sequence, removing all but the first exon of the Tbx15 gene. |
| |
| Allele Symbol |
a |
| Allele Name |
nonagouti |
Related Strains
Strains carrying a allele
View Strains carrying a (102 strains)
Strains carrying other alleles of a
View Strains carrying other alleles of a (67 strains)
Research Applications
This mouse can be used to support research in many areas including:
Tbx15de-H related
Developmental Biology Research
Skeletal Defects
Neurobiology Research
Vestibular and Hearing Defects
Sensorineural Research
Vestibular and Hearing Defects
References
Additional References
Price and Supply Information
| Strain Name: |
B6EiC3 a/A-Tbx15de-H/J |
| Stock Number: |
000551 |
Price Details
IMPORTANT NOTE: Prices are based on shipping destination.
The shipping destinations are:
*Pricing for Shipping Destination selected:
International
| Price(s) in US dollars ($) | |
| Cryorecovery Fee | $2470.00 | | | |
Supply Details
| Standard Supply | Repository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information. |
| Supply Notes |
Cryorecovery - Standard. The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two males and two females (two pairs) will be provided, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the delivery time to approximately 25 weeks. At least one member of each pair will be of known genotype and will carry the mutation if it is a mutant strain. Please note that pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Price represents a repository maintenance fee, which includes the cost of recovery of the strain from the cryopreservation resource and the periodic replacement of the frozen embryos used for recovery.
Cryorecovery to establish a Dedicated Supply for greater quantities of mice. One to two pairs will be recovered to establish a Dedicated Supply of mice. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services: Tel: 1-800-422-6423 or 1-207-288-5845; Email: jaxservices@jax.org.
Genomic DNA is available for this strain from the Mouse DNA Resource.
|
| Licensing | See General Terms and Conditions below
|
General Terms and Conditions
View
JAX® Mice & Services Conditions of Use.
The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene
genotyping programs to ensure the genetic background of JAX
® Mice strains as
well as the genotypes of strains with identified molecular mutations.
JAX
® Mice strains are only made available to researchers after meeting our
standards. However, the phenotype of each strain may not be fully
characterized and/or captured in the strain data sheets.
Therefore, we
cannot guarantee a strain's phenotype will meet all expectations. To
ensure that JAX
® Mice will meet the needs of individual research projects
or when requesting a strain that is new to your research, we suggest ordering
and performing tests on a small number of mice to determine suitability for
your particular project.
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