Strain Name: |
B6-Aw-J-EdaTa-6J.Cg-Sxr |
|---|---|
Stock Number: |
000552 |
Availability: | Repository-Cryopreserved |
General Terms and Conditions |
| Former Name |
B6-Aw-J-EdaTa-6J.Cg-Tp(Y)1CtSxr-a (Changed: 15-DEC-04
) |
|
B6-AB6-Aw-J-EdaTa-6J.Cg-Sxra (Changed: 15-DEC-04
) | |
| Genes & Alleles | Aw-J; Eda; EdaTa-6J; a; Tp(Y)1Ct; Tp(Y)1CtSxr-a; |
Product Information
Strain Details
Type Chromosome Aberration Additional information on Mice with Chromosomal Aberrations. Type JAX® GEMM® Strain - Congenic Additional information on JAX® GEMM® Strains. Type JAX® GEMM® Strain - Mutant Strain Species laboratory mouse Background Strain C57BL/6J-Aw-J/J Donor Strain Sxra Falconer strain via stock carrying Is(In7;X)1Ct Generation N16 Appearance
white-bellied agouti
Related Genotype: Aw/Aw
Gene & Allele Details
| Allele Symbol | Aw-J | ||
|---|---|---|---|
| Allele Name | white bellied agouti Jackson | ||
| Common Name(s) | AWJ; | ||
| Strain of Origin | C57BL/6J | ||
| Gene Symbol and Name | a, nonagouti | ||
| Chromosome | 2 | ||
| Gene Common Name(s) | AGSW; AGTI; AGTIL; ASP; As; MGC126092; MGC126093; SHEP9; agouti; agouti signal protein; agouti suppressor; | ||
| Allele Symbol | EdaTa-6J | ||
| Allele Name | tabby 6 Jackson | ||
| Common Name(s) | Ta6J; Tabby; | ||
| Strain of Origin | C57BL/6J-tp3J/J | ||
| Gene Symbol and Name | Eda, ectodysplasin-A | ||
| Chromosome | X | ||
| Gene Common Name(s) | ED1; ED1-A1; ED1-A2; EDA1; EDA2; Eda-A1; Eda-A2; HED; RGD1563178; Ta; XHED; XLHED; tabby; | ||
| Molecular Note | This allele is defined by a base pair deletion (at position 1049) resulting in a frameshift mutation. [MGI Ref ID J:42614] | ||
| Allele Symbol | Tp(Y)1CtSxr-a | ||
| Allele Name | Sex reversed, original transposition | ||
| Common Name(s) | Sxr; | ||
| Gene Symbol and Name | Tp(Y)1Ct, transposition, Chr Y, Cattanach 1 | ||
| Chromosome | XY | ||
| Gene Common Name(s) | Sxr; Tp1Ct; sex reversed, chromosomal aberration; | ||
| General Note | This genetic variant causes chromosomal females (X/X or X/O) to develop as males with small testes but otherwise normal morphology. X/Tp(Y)1Ct males are normal and fertile. | ||
| Molecular Note | The sex-reversed phenotype was shown to result from the transposition of a segment of the Y Chromosome short arm, which bears the genes for the H-Y antigen and for testis determination, to the distal end of the long arm. The distal ends of the X and Y Chromosomes consist of short pairing segments (the pseudoautosomal region) in which an obligate chiasma occurs at every meiosis. This results in transfer of the Tp(Y)1Ct segment, containing the male sex-determining gene, to one-half of the X-bearing gametesand loss of it from one-half of the Y-bearing gametes. At least five loci map to the Tp(Y)1Ct segment: Hya, Spy, Tdy, Zfy1, and Zfy2. [MGI Ref ID J:9332] | ||
Genotyping Protocols
Aw-J
Related Strains
Y Chromosomal Aberrations
001730 B6-Aw-J-EdaTa-6J.Cg-Sxrb Hya-/J 002021 B6Ei.LT-Y*/EiJ 000787 BALB/cByJ-Chr YMET/J 000908 C57BL/6J-Chr YMET/J View Y Chromosomal Aberrations (4 strains)
002016 B6(Cg)-Aw-J EdaTa-6J Chr YB6-Sxr/EiJ 001730 B6-Aw-J-EdaTa-6J.Cg-Sxrb Hya-/J 001809 B6-Aw-J.Cg-EdaTa-6J +/+ ArTfm/J 000338 C57BL/6J Aw-J-EdaTa-6J/J
000841 B6-Aw-J.CBy-EdaTa-By/J 000314 B6CBACa Aw-J/A-EdaTa/J-XO 000287 B6CBACa Aw-J/A-Plp1jp EdaTa/J 001232 C3H/HeJ-EdaTa-5J/J 000569 C57BL/6J-Aw-J-EdaTa +/+ ArTfm/J 003112 STOCK EdaTa-5J/J 000583 STOCK T(X;16)16H +/+ EdaTa
001730 B6-Aw-J-EdaTa-6J.Cg-Sxrb Hya-/J
Research Applications
This mouse can be used to support research in many areas including:
EdaTa-6J relatedReproductive Biology Research
Developmental Defects Affecting Gonads
Fertility Defects
Research Tools
Genetics Research
Dermatology Research
Color and White Spotting Defects
Skin and Hair Texture Defects
Developmental Biology Research
Eye Defects
Mouse/Human Gene Homologs
hypohidrotic ectodermal dysplasia
Sensorineural Research
Eye Defects
References
Additional ReferencesPrice and Supply Information
| Strain Name: | B6-Aw-J-EdaTa-6J.Cg-Sxr |
| Stock Number: | 000552 |
Price Details
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Supply Details
| Standard Supply | Repository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information. |
|---|---|
| Supply Notes |
Cryorecovery of Strains Needing Progeny Testing. The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two untested males and two untested females (two pairs) will be recovered, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the overall recovery time to approximately 25 weeks. However, all pups recovered will be sent. Progeny testing is required to identify the genotype of mice of this strain, as a genotyping assay is not available. This type of testing involves breeding the recovered animals and assessing the phenotype of the offspring in order to identify animals carrying the mutation of interest. We can perform the progeny testing for you as a service or we can ship all recovered animals (at least two untested pairs) to you for progeny testing at your facility. If you perform the progeny testing, there is NO guarantee that a carrier will be identified. If we perform progeny testing as a service, additional breeding time will be required. In this case, when a male and female (one pair) are identified that carry the mutation, they and their offspring will be shipped. Delivery time for strains requiring progeny testing often exceeds 25 weeks and may take 12 months or more due to the difficulties in breeding some strains. The progeny testing cost is in addition to the recovery cost and is based on the number of boxes used and the time taken to produce the mice identified as carrying the mutation. Please note that identified pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Please contact Customer Service for more information on the cost of progeny testing for a strain: Tel: 1-800-422-6423 or 1-207-288-5845. Cryorecovery to establish a Dedicated Supply for greater quantities of mice |
| Licensing | See General Terms and Conditions below |
General Terms and Conditions
View JAX® Mice & Services Conditions of Use.
The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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