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- Description
- Phenotype
- Genes & alleles
- Genotyping
- Health & husbandry
- References
- Purchasing information
- Terms of Use
Description
The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.
Strain Information
Former Names B6EiC3Sn-a/A-Egfrwa2 Wnt3avt/J (Changed: 15-DEC-04 ) Type Mutant Stock; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Species laboratory mouse Generation N35F2pN1 Appearance
black, wavy coat, tail defects
Related Genotype: a/a Egfrwa2 Wnt3avt/Egfrwa2 Wnt3avt
agouti, wavy coat, tail defects
Related Genotype: A/? Egfrwa2 Wnt3avt/Egfrwa2 Wnt3avt
black, normal coat and tail
Related Genotype: a/ a Egfrwa2 Wnt3avt/+ + or a/a ? ?/+ +
agouti, normal coat and tail
Related Genotype: A/? Egfrwa2Wnt3avt/+ + or A/? ? ?/+ +Description
Mice homozygous for the spontaneous waved 2 mutation (Egfrwa2) are recognizable at 2 to 3 days by curly whiskers. The first coat is waved but later coats are not; vibrissae usually remain curled and the guard hairs curved. Some homozygotes have eyelids open at birth. Fertile mutant females have impaired lactation. Mice homozygous for the vestigial tail spontaneous mutation (Wnt3avt) have very short tails, few presacral vertebrae, and abnormal formation of the lumbar vertebrae.Development
The vt mutation in Wnt3a arose spontaneously in the C57BR background.
Control Information
| Control | ||
|---|---|---|
| Untyped from the colony | ||
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying A allele
003301 (C57BL/6J x C3H-Eya1bor)F1/J 002083 B6 x B6EiC3 a/A-T(7;16)235Dn/J 000507 B6 x B6EiC3 a/A-Otcspf/J 000628 B6.CE-A Amy1b Amy2a5b/J 004200 B6;CBACa Aw-J/A-Npr2cn-2J/GrsrJ 000604 B6C3 a/A-T(10;13)199H +/+ Lystbg-J/J or Lystbg-2J/J 001752 B6CBCa Aw-J/A-T(7;15)9H/J 006450 B6EiC3 a/A-Vss/GrsrJ 000557 B6EiC3-+ a/LnpUl A/J 000504 B6EiC3Sn a/A-Cacnb4lh/J 001811 B6EiC3Sn a/A-Otcspf-ash/J 002343 B6EiC3Sn a/A-Otcspf/J 001923 B6EiC3Sn a/A-Ts(417)2Lws TimT(4;17)3Lws/J 000200 C3FeB6 A/Aw-J-Ankank/J 000638 C3FeB6 A/Aw-J-Spnb4qv-J/J 000283 LT.CAST-A/J 001759 STOCK A Tyrc Sha/J View Strains carrying A (17 strains)
000317 STOCK a/a Egfrwa2/J
006926 C57BL/6J-EgfrVel/J 002857 STOCK Egfrtm1Mag/J
004581 B6.129S1-Wnt3atm1Amc/J
Additional Web Information
JAX® NOTES, Winter 1994; 456. Origin of wa-2 Maintained at The Jackson Laboratory.
JAX® NOTES, Winter 1995; 460. The Waved-2 (wa2) Mutation, Chromosome 11.
Phenotype
Phenotype Information
assigned by genotype
Egfrwa2/Egfrwa2
B6EiC3Sn a/A-Egfrwa2 Wnt3avt/J
- cardiovascular system phenotype
- abnormal aortic valve morphology (MGI Ref ID J:60750)
- enlarged/thickened aortic valves
- skin/coat/nails phenotype
- abnormal hair texture (MGI Ref ID J:16986)
- touch/vibrissae phenotype
- abnormal vibrissa morphology (MGI Ref ID J:16986)
- endocrine/exocrine gland phenotype
- abnormal lactation (MGI Ref ID J:23326)
- reduction of milk within ducts of mammary glands and secretory vacuolation within lobules is less pronounced
- abnormal mammary gland morphology (MGI Ref ID J:23326)
- small mammary glands and the ratio of gland to adipose tissue is reduced
- reproductive system phenotype
- abnormal lactation (MGI Ref ID J:23326)
- reduction of milk within ducts of mammary glands and secretory vacuolation within lobules is less pronounced
- abnormal mammary gland morphology (MGI Ref ID J:23326)
- small mammary glands and the ratio of gland to adipose tissue is reduced
Wnt3avt/Wnt3avt
B6EiC3Sn a/A-Egfrwa2 Wnt3avt/J
- skeleton phenotype
- cervical vertebral transformation (MGI Ref ID J:69781)
- homeotic transformation of cervical vertebra 2 (C2) to C1 is seen in some homzygotes
- lumbar vertebral transformation (MGI Ref ID J:69781)
- transformation of L6 to sacral vertebra 1 (S1)
- sacral vertebral transformation (MGI Ref ID J:69781)
- transformation of S4 to S3
- thoracic vertebral transformation (MGI Ref ID J:69781)
- transformation of thoracic vertebra 9 (T9) to T10
- transformation of T13 to lumbar vertebra 1 (L1)
This mouse can be used to support research in many areas including:Egfrwa2 related
Wnt3avt relatedCancer Research
Growth Factors/Receptors/Cytokines
Dermatology Research
Skin and Hair Texture Defects
Developmental Biology Research
Neural Tube Defects
Endocrine Deficiency Research
Skin Defects
Immunology and Inflammation Research
Growth Factors/Receptors/Cytokines
Neurobiology Research
Neural Tube Defects
Developmental Biology Research
Neural Tube Defects
Neurobiology Research
Neural Tube Defects
Genes & Alleles
Gene & Allele Information
| Allele Symbol | A | ||
|---|---|---|---|
| Allele Name | wild type agouti | ||
| Allele Type | Spontaneous | ||
| Common Name(s) | dark-bellied agouti; | ||
| Strain of Origin | various | ||
| Gene Symbol and Name | a, nonagouti | ||
| Chromosome | 2 | ||
| Gene Common Name(s) | AGSW; AGTI; AGTIL; ASP; As; MGC126092; MGC126093; SHEP9; agouti; agouti signal protein; agouti suppressor; | ||
| General Note | The A allele is usually regarded as a wild-type allele. Hairs are black with a subapical yellow band. This black-yellow-black pattern is referred to as agouti. The general appearance is yellowish brown, slightly lighter on the belly than on the back. | ||
| Molecular Note | This allele, often referred to as wild-type, comprises a novel 131 amino acid protein encoded in a gene comprising four exons, three coding, spanning 18kb. Unique changes in this gene account for all other alleles that have been molecularly characterized. The expression of this allele is almost always dominant to other alleles of this gene. [MGI Ref ID J:3523] | ||
| Allele Symbol | Egfrwa2 | ||
| Allele Name | waved 2 | ||
| Allele Type | Spontaneous | ||
| Common Name(s) | wa2; waved2; | ||
| Strain of Origin | STOCK ac | ||
| Gene Symbol and Name | Egfr, epidermal growth factor receptor | ||
| Chromosome | 11 | ||
| Gene Common Name(s) | 9030024J15Rik; AI552599; ERBB; ERBB1; ErbB-1; Erbb; Errp; HER1; PIG61; RIKEN cDNA 9030024J15 gene; Wa5; avian erythroblastic leukemia viral (v-erb-b) oncogene homolog; avian erythroblastosis oncogene B; expressed sequence AI552599; mENA; wa-2; wa2; waved 2; waved 5; | ||
| General Note |
Found by Keeler in an ``abnormal corpus callosum'' stock at the Bussey Institution, this mutant is very similar to Tgfawa1. Homozygotes can be recognized at 2 to 3 days by their curly whiskers. The first coat is waved but later coats are not. The vibrissae usually remain curled and the guard hairs curved. Some homozygotes have eyelids open at birth (J:13052). Butler and Robertson ascribed the open eyelid condition to an independent gene, which they called squint, but it is probably a pleiotropic effect of Egfrwa2 (J:15239). The proportions of guard hairs and zigzags are about normal in Egfrwa2/Egfrwa2 mice, but the hairs show irregularities and narrowing of the medulla, usually accompanied by thickening of the cortex. Bending occurs between these areas (J:5260). In fusion chimeras between Egfrwa2/Egfrwa2 and +/+ mice, waved and normal hairs occur in a patchy distribution, suggesting that Egfrwa2 acts locally in the hair folliclecells (J:5130). The waved-2 phenotype has been shown to result from a point mutation in the Egfr gene. Expression of EGFR in the outer hair root sheath, along with expression of its TGFA ligand in the inner root sheath, suggests that the waved-1 and waved-2 effects on hair growth may result from failures of signaling by this ligand-receptor system in skin (J:16986). Impairment of lactation in fertile mutant females is another effect of Egfrwa2 (J:23326). Phenotypic Similarity to Human Syndrome: aortic valve disease (J:60750). | ||
| Molecular Note | A T-to-G transversion mutation in the sequences encoding the tyrosine kinase domain is predicted to result in a substitution of a glycine for a highly conserved valine at position 743 in the third kinase subdomain. [MGI Ref ID J:16986] | ||
| Allele Symbol | Wnt3avt | ||
| Allele Name | vestigial tail | ||
| Allele Type | Spontaneous | ||
| Common Name(s) | vt; | ||
| Strain of Origin | C57BR | ||
| Gene Symbol and Name | Wnt3a, wingless-related MMTV integration site 3A | ||
| Chromosome | 11 | ||
| Gene Common Name(s) | MGC119418; MGC119419; MGC119420; Wnt-3a; vestigial tail; vt; | ||
| Molecular Note | Examination of the Wnt3a gene by Southern blot, Northern blot on adult lung tissue and cDNA sequence analysis revealed no sign of an obvious mutation that could account for a mutant phenotype. However, this mutation and a targeted mutation, Wnt3atm1Amc, were demonstrated to be noncomplemeting alleles. Further evidence from whole mount in situ hybridization studies on embryos demonstrated that expression of the encoded protein is reduced in homozygous embryos, suggesting that this hypomorphicallele results from a mutation in a regulatory element. [MGI Ref ID J:31335] | ||
Genotyping
Genotyping Information
This strain will not have a genotyping protocol or one is not currently available.
Helpful Links
Genotyping resources and troubleshooting
References
References
Additional References
Beland M; Pilon N; Houle M; Oh K; Sylvestre JR; Prinos P; Lohnes D. 2004. Cdx1 autoregulation is governed by a novel Cdx1-LEF1 transcription complex. Mol Cell Biol 24(11):5028-38. [PubMed: 15143193] [MGI Ref ID J:91084]
Fitch KR; McGowan KA; Van Raamsdonk CD; Fuchs H; Lee D; Puech A; Herault Y; Threadgill DW; De Angelis MH; Barsh GS. 2003. Genetics of dark skin in mice. Genes Dev 17(2):214-28. [PubMed: 12533510] [MGI Ref ID J:81301]
Greco TL; Takada S; Newhouse MM; McMahon JA; McMahon AP; Camper SA. 1996. Analysis of the vestigial tail mutation demonstrates that Wnt-3a gene dosage regulates mouse axial development. Genes Dev 10(3):313-24. [PubMed: 8595882] [MGI Ref ID J:31335]
Luetteke NC; Phillips HK; Qiu TH; Copeland NG; Earp HS; Jenkins NA; Lee DC. 1994. The mouse waved-2 phenotype results from a point mutation in the EGF receptor tyrosine kinase. Genes Dev 8(4):399-413. [PubMed: 8125255] [MGI Ref ID J:16986]
Prinos P; Joseph S; Oh K; Meyer BI; Gruss P; Lohnes D. 2001. Multiple Pathways Governing Cdx1 Expression during Murine Development. Dev Biol 239(2):257-69. [PubMed: 11784033] [MGI Ref ID J:72581]
Sunnarborg SW; Hinkle CL; Stevenson M; Russell WE; Raska CS; Peschon JJ; Castner BJ; Gerhart MJ; Paxton RJ; Black RA; Lee DC. 2002. Tumor necrosis factor-alpha converting enzyme (TACE) regulates epidermal growth factor receptor ligand availability. J Biol Chem 277(15):12838-45. [PubMed: 11823465] [MGI Ref ID J:75887]
Threadgill DW; Dlugosz AA; Hansen LA; Tennenbaum T; Lichti U; Yee D; LaMantia C; Mourton T; Herrup K; Harris RC; Barnard JA; Yuspa SH; Coffey RJ; Magnuson T. 1995. Targeted disruption of mouse EGF receptor: effect of genetic background on mutant phenotype. Science 269(5221):230-4. [PubMed: 7618084] [MGI Ref ID J:26833]
A relatedEgfrwa2 relatedBlewitt ME; Vickaryous NK; Hemley SJ; Ashe A; Bruxner TJ; Preis JI; Arkell R; Whitelaw E. 2005. An N-ethyl-N-nitrosourea screen for genes involved in variegation in the mouse. Proc Natl Acad Sci U S A 102(21):7629-34. [PubMed: 15890782] [MGI Ref ID J:99816]
Bultman SJ; Michaud EJ; Woychik RP. 1992. Molecular characterization of the mouse agouti locus. Cell 71(7):1195-204. [PubMed: 1473152] [MGI Ref ID J:3523]
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Czyzyk TA; Sikorski MA; Yang L; McKnight GS. 2008. Disruption of the RIIbeta subunit of PKA reverses the obesity syndrome of Agouti lethal yellow mice. Proc Natl Acad Sci U S A 105(1):276-81. [PubMed: 18172198] [MGI Ref ID J:131039]
Dickie MM. 1969. Mutations at the agouti locus in the mouse. J Hered 60(1):20-5. [PubMed: 5798139] [MGI Ref ID J:30922]
Dry FW. 1928. The agouti coloration of the mouse (Mus Musculus) and the rat (Mus Norvegicus). J Genet 20:131-144. [MGI Ref ID J:46318]
Guido V, and The Mouse Mutant Resource (MMR) at The Jackson Laboratory. 2002. Two new mutations of white bellied agouti, w-46J and w-47J MGI Direct Data Submission :. [MGI Ref ID J:77218]
Jackson IJ; Budd PS; Keighren M; McKie L. 2007. Humanized MC1R transgenic mice reveal human specific receptor function. Hum Mol Genet 16(19):2341-8. [PubMed: 17652101] [MGI Ref ID J:129904]
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Perry WL; Copeland NG; Jenkins NA. 1994. The molecular basis for dominant yellow agouti coat color mutations. Bioessays 16(10):705-7. [PubMed: 7980472] [MGI Ref ID J:21244]
Quevedo WC Jr.; Chase HB. 1958. An analysis of the light mutation of coat color in mice. J Morphol 102:329-345. [MGI Ref ID J:13094]
Silvers WK. 1979. The Coat Colors of Mice; A Model for Mammalian Gene Action and Interaction. In: The Coat Colors of Mice. Springer-Verlag, New York. [MGI Ref ID J:78801]
Wnt3avt relatedAguirre A; Dupree JL; Mangin JM; Gallo V. 2007. A functional role for EGFR signaling in myelination and remyelination. Nat Neurosci 10(8):990-1002. [PubMed: 17618276] [MGI Ref ID J:124200]
Apostolakis EM; Garai J; Lohmann JE; Clark JH; O'Malley BW. 2000. Epidermal growth factor activates reproductive behavior independent of ovarian steroids in female rodents. Mol Endocrinol 14(7):1086-98. [PubMed: 10894157] [MGI Ref ID J:125045]
Barrick CJ; Roberts RB; Rojas M; Rajamannan NM; Suitt CB; O'Brien KD; Smyth SS; Threadgill DW. 2009. Reduced EGFR causes abnormal valvular differentiation leading to calcific aortic stenosis and left ventricular hypertrophy in C57BL/6J but not 129S1/SvImJ mice. Am J Physiol Heart Circ Physiol 297(1):H65-75. [PubMed: 19448146] [MGI Ref ID J:151100]
Bernal NP; Stehr W; Coyle R; Erwin CR; Warner BW. 2006. Epidermal growth factor receptor signaling regulates Bax and Bcl-w expression and apoptotic responses during intestinal adaptation in mice. Gastroenterology 130(2):412-23. [PubMed: 16472596] [MGI Ref ID J:124922]
Blaine SA; Ray KC; Branch KM; Robinson PS; Whitehead RH; Means AL. 2009. Epidermal growth factor receptor regulates pancreatic fibrosis. Am J Physiol Gastrointest Liver Physiol 297(3):G434-41. [PubMed: 19608732] [MGI Ref ID J:152089]
Butler L; Robertson DA. 1953. A new eye abnormality in the house mouse J Hered 44:13-16. [MGI Ref ID J:15329]
CARTER TC; PHILLIPS RJ. 1953. The sex distribution of waved-2, shaker-2 and Rex in the house mouse. Z Indukt Abstamm Vererbungsl 85(4):564-78. [PubMed: 13170359] [MGI Ref ID J:225]
Chansel D; Ciroldi M; Vandermeersch S; Jackson LF; Gomez AM; Henrion D; Lee DC; Coffman TM; Richard S; Dussaule JC; Tharaux PL. 2006. Heparin binding EGF is necessary for vasospastic response to endothelin. FASEB J 20(11):1936-8. [PubMed: 16877529] [MGI Ref ID J:129734]
Chen B; Bronson RT; Klaman LD; Hampton TG; Wang JF; Green PJ; Magnuson T; Douglas PS; Morgan JP; Neel BG. 2000. Mice mutant for Egfr and Shp2 have defective cardiac semilunar valvulogenesis. Nat Genet 24(3):296-9. [PubMed: 10700187] [MGI Ref ID J:60750]
Dackor J; Caron KM; Threadgill DW. 2009. Placental and embryonic growth restriction in mice with reduced function epidermal growth factor receptor alleles. Genetics 183(1):207-18. [PubMed: 19564486] [MGI Ref ID J:153156]
Ferby I; Reschke M; Kudlacek O; Knyazev P; Pante G; Amann K; Sommergruber W; Kraut N; Ullrich A; Fassler R; Klein R. 2006. Mig6 is a negative regulator of EGF receptor-mediated skin morphogenesis and tumor formation. Nat Med 12(5):568-73. [PubMed: 16648858] [MGI Ref ID J:109556]
Fitch KR; McGowan KA; Van Raamsdonk CD; Fuchs H; Lee D; Puech A; Herault Y; Threadgill DW; De Angelis MH; Barsh GS. 2003. Genetics of dark skin in mice. Genes Dev 17(2):214-28. [PubMed: 12533510] [MGI Ref ID J:81301]
Flamant M; Tharaux PL; Placier S; Henrion D; Coffman T; Chatziantoniou C; Dussaule JC. 2003. Epidermal growth factor receptor trans-activation mediates the tonic and fibrogenic effects of endothelin in the aortic wall of transgenic mice. FASEB J 17(2):327-9. [PubMed: 12475899] [MGI Ref ID J:127931]
Fowler KJ; Walker F; Alexander W; Hibbs ML; Nice EC; Bohmer RM; Mann GB; Thumwood C; Maglitto R; Danks JA; Chetty R; Burgess AW; Dunn AR. 1995. A mutation in the epidermal growth factor receptor in waved-2 mice has a profound effect on receptor biochemistry that results in impaired lactation. Proc Natl Acad Sci U S A 92(5):1465-9. [PubMed: 7533293] [MGI Ref ID J:23326]
Gillgrass A; Cardiff RD; Sharan N; Kannan S; Muller WJ. 2003. Epidermal growth factor receptor-dependent activation of Gab1 is involved in ErbB-2-mediated mammary tumor progression. Oncogene 22(57):9151-5. [PubMed: 14668796] [MGI Ref ID J:87087]
Helmrath MA; Erwin CR; Warner BW. 1997. A defective EGF-receptor in waved-2 mice attenuates intestinal adaptation. J Surg Res 69(1):76-80. [PubMed: 9202650] [MGI Ref ID J:41901]
Hogan ME; King LE Jr; Sundberg JP. 1995. Defects of pelage hairs in 20 mouse mutations. J Invest Dermatol 104(5 Suppl):31S-32S. [PubMed: 7738386] [MGI Ref ID J:25255]
Ishibe S; Karihaloo A; Ma H; Zhang J; Marlier A; Mitobe M; Togawa A; Schmitt R; Czyczk J; Kashgarian M; Geller DS; Thorgeirsson SS; Cantley LG. 2009. Met and the epidermal growth factor receptor act cooperatively to regulate final nephron number and maintain collecting duct morphology. Development 136(2):337-45. [PubMed: 19103805] [MGI Ref ID J:143511]
Jackson LF; Qiu TH; Sunnarborg SW; Chang A; Zhang C; Patterson C; Lee DC. 2003. Defective valvulogenesis in HB-EGF and TACE-null mice is associated with aberrant BMP signaling. EMBO J 22(11):2704-16. [PubMed: 12773386] [MGI Ref ID J:83820]
Keegan BP; Sheflin LG; Spaulding SW. 2000. The internalization and endosomal trafficking of the EGF receptor in response to EGF is delayed in the waved-2 mouse liver. Biochem Biophys Res Commun 267(3):881-6. [PubMed: 10673385] [MGI Ref ID J:60172]
Keeler CE. 1935. A second rexoid coat character in the house mouse. J Hered 26:189-191. [MGI Ref ID J:13052]
Lee D; Cross SH; Strunk KE; Morgan JE; Bailey CL; Jackson IJ; Threadgill DW. 2004. Wa5 is a novel ENU-induced antimorphic allele of the epidermal growth factor receptor. Mamm Genome 15(7):525-36. [PubMed: 15366372] [MGI Ref ID J:92308]
Lee D; Pearsall RS; Das S; Dey SK; Godfrey VL; Threadgill DW. 2004. Epiregulin is not essential for development of intestinal tumors but is required for protection from intestinal damage. Mol Cell Biol 24(20):8907-16. [PubMed: 15456865] [MGI Ref ID J:93327]
Ling BC; Wu J; Miller SJ; Monk KR; Shamekh R; Rizvi TA; Decourten-Myers G; Vogel KS; DeClue JE; Ratner N. 2005. Role for the epidermal growth factor receptor in neurofibromatosis-related peripheral nerve tumorigenesis. Cancer Cell 7(1):65-75. [PubMed: 15652750] [MGI Ref ID J:95933]
Liu B; Xia X; Zhu F; Park E; Carbajal S; Kiguchi K; DiGiovanni J; Fischer SM; Hu Y. 2008. IKKalpha is required to maintain skin homeostasis and prevent skin cancer. Cancer Cell 14(3):212-25. [PubMed: 18772111] [MGI Ref ID J:141162]
Luetteke NC; Phillips HK; Qiu TH; Copeland NG; Earp HS; Jenkins NA; Lee DC. 1994. The mouse waved-2 phenotype results from a point mutation in the EGF receptor tyrosine kinase. Genes Dev 8(4):399-413. [PubMed: 8125255] [MGI Ref ID J:16986]
Mak KK; Chan SY. 2003. Epidermal growth factor as a biologic switch in hair growth cycle. J Biol Chem 278(28):26120-6. [PubMed: 12714603] [MGI Ref ID J:84423]
McLaren A. 1971. The microscopic appearance of waved-2 mouse hairs. Genet Res 17(3):257-60. [PubMed: 5142632] [MGI Ref ID J:5260]
McLaren A; Bowman P. 1969. Mouse chimaeras derived from fusion of embryos differing by nine genetic factors. Nature 224(216):238-40. [PubMed: 5344599] [MGI Ref ID J:5130]
Minami S; Iwamoto R; Mekada E. 2008. HB-EGF decelerates cell proliferation synergistically with TGFalpha in perinatal distal lung development. Dev Dyn 237(1):247-58. [PubMed: 18069687] [MGI Ref ID J:130339]
Mine N; Iwamoto R; Mekada E. 2005. HB-EGF promotes epithelial cell migration in eyelid development. Development 132(19):4317-26. [PubMed: 16141218] [MGI Ref ID J:101734]
Mrosovsky N; Redlin U; Roberts RB; Threadgill DW. 2005. Masking in waved-2 mice: EGF receptor control of locomotion questioned. Chronobiol Int 22(6):963-74. [PubMed: 16393701] [MGI Ref ID J:116871]
Ogawa M; Nomura S; Varro A; Wang TC; Goldenring JR. 2006. Altered metaplastic response of waved-2 EGF receptor mutant mice to acute oxyntic atrophy. Am J Physiol Gastrointest Liver Physiol 290(4):G793-804. [PubMed: 16306133] [MGI Ref ID J:106796]
Panigone S; Hsieh M; Fu M; Persani L; Conti M. 2008. Luteinizing hormone signaling in preovulatory follicles involves early activation of the epidermal growth factor receptor pathway. Mol Endocrinol 22(4):924-36. [PubMed: 18187604] [MGI Ref ID J:132998]
Prevot V; Lomniczi A; Corfas G; Ojeda SR. 2005. erbB-1 and erbB-4 receptors act in concert to facilitate female sexual development and mature reproductive function. Endocrinology 146(3):1465-72. [PubMed: 15591145] [MGI Ref ID J:97399]
Qu CK; Yu WM; Azzarelli B; Feng GS. 1999. Genetic evidence that Shp-2 tyrosine phosphatase is a signal enhancer of the epidermal growth factor receptor in mammals. Proc Natl Acad Sci U S A 96(15):8528-33. [PubMed: 10411909] [MGI Ref ID J:75413]
Richards WG; Sweeney WE; Yoder BK; Wilkinson JE; Woychik RP; Avner ED. 1998. Epidermal growth factor receptor activity mediates renal cyst formation in polycystic kidney disease. J Clin Invest 101(5):935-9. [PubMed: 9486961] [MGI Ref ID J:46764]
Roberts RB; Min L; Washington MK; Olsen SJ; Settle SH; Coffey RJ; Threadgill DW. 2002. Importance of epidermal growth factor receptor signaling in establishment of adenomas and maintenance of carcinomas during intestinal tumorigenesis. Proc Natl Acad Sci U S A 99(3):1521-6. [PubMed: 11818567] [MGI Ref ID J:74510]
Sibilia M; Fleischmann A; Behrens A; Stingl L; Carroll J; Watt FM; Schlessinger J; Wagner EF. 2000. The EGF receptor provides an essential survival signal for SOS-dependent skin tumor development Cell 102(2):211-20. [PubMed: 10943841] [MGI Ref ID J:63426]
Sunnarborg SW; Hinkle CL; Stevenson M; Russell WE; Raska CS; Peschon JJ; Castner BJ; Gerhart MJ; Paxton RJ; Black RA; Lee DC. 2002. Tumor necrosis factor-alpha converting enzyme (TACE) regulates epidermal growth factor receptor ligand availability. J Biol Chem 277(15):12838-45. [PubMed: 11823465] [MGI Ref ID J:75887]
Wang DZ; Hammond VE; Abud HE; Bertoncello I; McAvoy JW; Bowtell DD. 1997. Mutation in Sos1 dominantly enhances a weak allele of the EGFR, demonstrating a requirement for Sos1 in EGFR signaling and development. Genes Dev 11(3):309-20. [PubMed: 9030684] [MGI Ref ID J:38321]
Wu J; Crimmins JT; Monk KR; Williams JP; Fitzgerald ME; Tedesco S; Ratner N. 2006. Perinatal epidermal growth factor receptor blockade prevents peripheral nerve disruption in a mouse model reminiscent of benign world health organization grade I neurofibroma. Am J Pathol 168(5):1686-96. [PubMed: 16651634] [MGI Ref ID J:108591]
Yamaoka T; Yan F; Cao H; Hobbs SS; Dise RS; Tong W; Polk DB. 2008. Transactivation of EGF receptor and ErbB2 protects intestinal epithelial cells from TNF-induced apoptosis. Proc Natl Acad Sci U S A 105(33):11772-7. [PubMed: 18701712] [MGI Ref ID J:138989]
Zenz R; Scheuch H; Martin P; Frank C; Eferl R; Kenner L; Sibilia M; Wagner EF. 2003. c-Jun Regulates Eyelid Closure and Skin Tumor Development through EGFR Signaling. Dev Cell 4(6):879-89. [PubMed: 12791272] [MGI Ref ID J:84512]
Barrick CJ; Roberts RB; Rojas M; Rajamannan NM; Suitt CB; O'Brien KD; Smyth SS; Threadgill DW. 2009. Reduced EGFR causes abnormal valvular differentiation leading to calcific aortic stenosis and left ventricular hypertrophy in C57BL/6J but not 129S1/SvImJ mice. Am J Physiol Heart Circ Physiol 297(1):H65-75. [PubMed: 19448146] [MGI Ref ID J:151100]
Beland M; Pilon N; Houle M; Oh K; Sylvestre JR; Prinos P; Lohnes D. 2004. Cdx1 autoregulation is governed by a novel Cdx1-LEF1 transcription complex. Mol Cell Biol 24(11):5028-38. [PubMed: 15143193] [MGI Ref ID J:91084]
Chan BW; Chan KS; Koide T; Yeung SM; Leung MB; Copp AJ; Loeken MR; Shiroishi T; Shum AS. 2002. Maternal diabetes increases the risk of caudal regression caused by retinoic acid. Diabetes 51(9):2811-6. [PubMed: 12196475] [MGI Ref ID J:106970]
Dackor J; Caron KM; Threadgill DW. 2009. Placental and embryonic growth restriction in mice with reduced function epidermal growth factor receptor alleles. Genetics 183(1):207-18. [PubMed: 19564486] [MGI Ref ID J:153156]
Dale JK; Malapert P; Chal J; Vilhais-Neto G; Maroto M; Johnson T; Jayasinghe S; Trainor P; Herrmann B; Pourquie O. 2006. Oscillations of the snail genes in the presomitic mesoderm coordinate segmental patterning and morphogenesis in vertebrate somitogenesis. Dev Cell 10(3):355-66. [PubMed: 16516838] [MGI Ref ID J:106622]
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Health & husbandry
Health & Colony Maintenance Information
Currently there no information available for this strain. This may be due to the supply level of this strain.
Purchasing information
Pricing, Supply Level & Notes, Controls, General Terms & Conditions
Pricing
| Pricing for USA, Canada and Mexico shipping destinations |
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Animals Provided
Price (US dollars $) Cryorecovery Fee $1900.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Additional Supply Details
| Pricing for International shipping destinations |
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Animals Provided
Price (US dollars $) Cryorecovery Fee $2470.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Additional Supply Details
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Supply Details
| Standard Supply | Cryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information. |
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| Supply Notes |
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Control Information
| Control | ||
|---|---|---|
| Untyped from the colony | ||
| Considerations for Choosing Controls | ||
| USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
| International - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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JAX® Mice, Products & Services Conditions of Use
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