JAX Mice Database - 000553 B6EiC3Sn a/A-Egfr<wa2> Wnt3a<vt>/J

Strain Name:	B6EiC3Sn a/A-Egfr^wa2 Wnt3a^vt/J
Stock Number:	000553
Availability:	Repository-Cryopreserved

Description
Phenotype
Genes & alleles
Genotyping
Health & husbandry
References
Purchasing information
Terms of Use

Description

Strain Information

Former Names B6EiC3Sn-a/A-Egfr^wa2 Wnt3a^vt/J (Changed: 15-DEC-04 )

Type Mutant Stock;
Additional information on Genetically Engineered Mutant Mice.

Species laboratory mouse

Generation N35F2pN1

Appearance
black, wavy coat, tail defects
Related Genotype: a/a Egfr^wa2 Wnt3a^vt/Egfr^wa2 Wnt3a^vt

agouti, wavy coat, tail defects
Related Genotype: A/? Egfr^wa2 Wnt3a^vt/Egfr^wa2 Wnt3a^vt

black, normal coat and tail
Related Genotype: a/ a Egfr^wa2 Wnt3a^vt/+ + or a/a ? ?/+ +

agouti, normal coat and tail
Related Genotype: A/? Egfr^wa2Wnt3a^vt/+ + or A/? ? ?/+ +
Description
Mice homozygous for the spontaneous waved 2 mutation (Egfr^wa2) are recognizable at 2 to 3 days by curly whiskers. The first coat is waved but later coats are not; vibrissae usually remain curled and the guard hairs curved. Some homozygotes have eyelids open at birth. Fertile mutant females have impaired lactation. Mice homozygous for the vestigial tail spontaneous mutation (Wnt3a^vt) have very short tails, few presacral vertebrae, and abnormal formation of the lumbar vertebrae.
Development
The vt mutation in Wnt3a arose spontaneously in the C57BR background.

Control Information

	Control
	Untyped from the colony

Considerations for Choosing Controls

Related Strains

Strains carrying A allele

003301 (C57BL/6J x C3H-Eya1^bor)F1/J

002083 B6 x B6EiC3 a/A-T(7;16)235Dn/J

000507 B6 x B6EiC3 a/A-Otc^spf/J

000628 B6.CE-A Amy1^b Amy2^b/J

004200 B6;CBACa A^w-J/A-Npr2^cn-2J/J

000604 B6C3 a/A-T(10;13)199H +/+ Lyst^bg-J/J or Lyst^bg-2J/J

001752 B6CBCa A^w-J/A-T(7;15)9H/J

006450 B6EiC3 a/A-Vss/J

000557 B6EiC3-+ a/Lnp^Ul A/J

000504 B6EiC3Sn a/A-Cacnb4^lh/J

001811 B6EiC3Sn a/A-Otc^spf-ash/J

002343 B6EiC3Sn a/A-Otc^spf/J

001923 B6EiC3Sn a/A-Ts(4¹⁷)2Lws Tim/J

000200 C3FeB6 A/A^w-J-Ank^ank/J

000638 C3FeB6 A/A^w-J-Spnb4^qv-J/J

000283 LT.CAST-A/J

001759 STOCK A Tyr^c Sha/J

View Strains carrying A (17 strains)

Strains carrying Egfr^wa2 allele

000317 STOCK a/a Egfr^wa2/J

View Strains carrying Egfr^wa2 (1 strain)

Strains carrying other alleles of Egfr

006926 C57BL/6J-Egfr^Vel/J

002857 STOCK Egfr^tm1Mag/J

View Strains carrying other alleles of Egfr (2 strains)

Strains carrying other alleles of Wnt3a

004581 B6.129S1-Wnt3a^tm1Amc/J

View Strains carrying other alleles of Wnt3a (1 strain)

Strains carrying other alleles of a

000251 AEJ.Cg-a^e +/a Gdf5^bp-H/J

000202 AEJ/Gn-bd/J

000199 AEJ/GnLeJ

000427 B10.CE-H13^b A^w/(30NX)SnJ

000420 B10.LP-H13^b A^w/Sn

000477 B10.PA-Pldn^pa H3^e a^t/SnJ

000419 B10.UW-H3^b we Pax1^un a^t/SnJ

003879 B10;TFLe-a/a T tf/+ tf/J

001538 B6 x B6C3Sn a/A-T(1;9)27H/J

000916 B6 x B6C3Sn a/A-T(5;12)31H/J

000602 B6 x B6C3Sn a/A-T(8;16)17H/J

000593 B6 x B6CBCa A^w-J/A-Grid2^Lc T(2;6)7Ca Mitf^Mi-wh/J

000502 B6 x B6CBCa A^w-J/A-Myo5a^flr Gnb5^flr/J

000599 B6 x B6CBCa A^w-J/A-T(5;13)264Ca Kit^W-v/J

000618 B6 x FSB/GnEi a/a Ctsl^fs/J

000577 B6 x STOCK a Oca2^p Hps5^ru2 Ednrb^s/J

000601 B6 x STOCK a/a T(7;18)50H/J

000592 B6 x STOCK T(2;4)13H a/J

002016 B6(Cg)-A^w-J Eda^Ta-6J Chr Y^B6-Sxr/EiJ

000552 B6-A^w-J-Eda^Ta-6J.Cg-Sxr

001730 B6-A^w-J-Eda^Ta-6J.Cg-Sxr^b Hya^-/J

000841 B6-A^w-J.CBy-Eda^Ta-By/J

001809 B6-A^w-J.Cg-Eda^Ta-6J +/+ Ar^Tfm/J

000600 B6-Gpi1^b x B6CBCa A^w-J/A-T(7;15)9H Gpi1^a/J

000769 B6.C/(HZ18)By-a^t-44J/J

000001 B6.C3 A/a Mgrn1^md/J

000203 B6.C3-A^iy/a/J

001572 B6.C3-a^m-J/J

000017 B6.C3Fe-A^vy/J

005505 B6.Cg-A^y Slc7a11^sut/LmLlp

000021 B6.Cg-A^y/J

100409 B6129PF1/J-A^w-J/A^w

004200 B6;CBACa A^w-J/A-Npr2^cn-2J/J

000785 B6;D2-a Es1^e/J

000505 B6C3 A^w-J/A-Muted^mu/J

000604 B6C3 a/A-T(10;13)199H +/+ Lyst^bg-J/J or Lyst^bg-2J/J

002807 B6C3Fe a/a-Meox2^fla/J

000224 B6C3Fe a/a-Scyl1^mdf/J

001037 B6C3Fe a/a-Agtpbp1^pcd/J

000221 B6C3Fe a/a-Alx4^lst-J/J

002062 B6C3Fe a/a-Atp7a^Mo-8J/J

001756 B6C3Fe a/a-Cacng2^stg/J

001815 B6C3Fe a/a-Col1a2^oim/J

000231 B6C3Fe a/a-Csf1^op/J

000209 B6C3Fe a/a-Dh/J

000211 B6C3Fe a/a-Dst^dt-J/J

000210 B6C3Fe a/a-Edar^dl-J/J

000207 B6C3Fe a/a-Edaradd^cr/J

000182 B6C3Fe a/a-Eef1a2^wst/J

001278 B6C3Fe a/a-Glra1^spd/J

000241 B6C3Fe a/a-Glrb^spa/J

002875 B6C3Fe a/a-Hoxd13^spdh/J

000304 B6C3Fe a/a-Krt71^Ca Scn8a^med-J/J

000226 B6C3Fe a/a-Large^myd/J

000636 B6C3Fe a/a-Lmx1a^dr-J/J

001280 B6C3Fe a/a-Lse/J

001573 B6C3Fe a/a-Mitf^Mi/J

001035 B6C3Fe a/a-Napa^hyh/J

000181 B6C3Fe a/a-Otog^twt/J

000278 B6C3Fe a/a-Papss2^bm Hps1^ep Hps6^ru/J

000205 B6C3Fe a/a-Papss2^bm/J

002078 B6C3Fe a/a-Pcdh15^av-2J/J

000246 B6C3Fe a/a-Pitpna^vb/J

001430 B6C3Fe a/a-Ptch1^mes/J

000506 B6C3Fe a/a-Qk^qk/J

000235 B6C3Fe a/a-Reln^rl/J

000237 B6C3Fe a/a-Rora^sg/J

000290 B6C3Fe a/a-Sox10^Dom/J

000230 B6C3Fe a/a-Tcirg1^oc/J

003612 B6C3Fe a/a-Trak1^hyrt/J

001512 B6C3Fe a/a-Ttn^mdm/J

001607 B6C3Fe a/a-Unc5c^rcm/J

000005 B6C3Fe a/a-Wc/J

000243 B6C3Fe a/a-Wnt1^sw/J

000248 B6C3Fe a/a-Xpl/J

001750 B6C3Fe a/a-Xs^J/J

000624 B6C3Fe a/a-anx/J

003020 B6C3Fe a/a-dep/J

002018 B6C3Fe a/a-din/J

002339 B6C3Fe a/a-nma/J

000240 B6C3Fe a/a-soc/J

000063 B6C3Fe a/a-sy/J

001055 B6C3Fe a/a-tip/J

000245 B6C3Fe a/a-tn/J

000065 B6C3Fe a/a-we Pax1^un a^t/J

000296 B6C3Fe-a/a Hoxa13^Hd Mcoln3^Va-J/J

000019 B6C3Fe-a/a-Itpr1^opt/J

001022 B6C3FeF1/J a/a

000314 B6CBACa A^w-J/A-Eda^Ta/J-XO

000501 B6CBACa A^w-J/A-Aifm1^Hq/J

001046 B6CBACa A^w-J/A-Grid2^Lc/J

000500 B6CBACa A^w-J/A-Gs/J

002703 B6CBACa A^w-J/A-Hydin^hy3/J

000247 B6CBACa A^w-J/A-Kcnj6^wv/J

000287 B6CBACa A^w-J/A-Plp1^jp Eda^Ta/J

000515 B6CBACa A^w-J/A-Sfn^Er/J

000242 B6CBACa A^w-J/A-spc/J

000288 B6CBACa A^w-J/A-we a Mafb^kr/J

001201 B6CBACaF1/J-A^w-J/A

001752 B6CBCa A^w-J/A-T(7;15)9H/J

000971 B6EiC3 a/A-Och/J

000551 B6EiC3 a/A-Tbx15^de-H/J

006450 B6EiC3 a/A-Vss/J

000557 B6EiC3-+ a/Lnp^Ul A/J

000503 B6EiC3Sn a/A-Gy/J

001811 B6EiC3Sn a/A-Otc^spf-ash/J

002343 B6EiC3Sn a/A-Otc^spf/J

000391 B6EiC3Sn a/A-Pax6^Sey-Dey/J

001924 B6EiC3Sn a/A-Ts(17¹⁶)65Dn

001923 B6EiC3Sn a/A-Ts(4¹⁷)2Lws Tim/J

000200 C3FeB6 A/A^w-J-Ank^ank/J

000638 C3FeB6 A/A^w-J-Spnb4^qv-J/J

001203 C3FeB6F1/J A/A^w-J

000225 C3FeLe.B6 a/a-Ptpn6^me/J

008425 C3FeLe.B6-a Trl/J

000198 C3FeLe.B6-a/J

000291 C3FeLe.Cg-a/a Hm Kitl^Sl Krt71^Ca-J/J

001272 C3H/HeSnJ-A^hvy/J

000099 C3HeB/FeJ-A^vy/J

001886 C3HeB/FeJLe a/a-gnd/J

000338 C57BL/6J A^w-J-Eda^Ta-6J/J

000584 C57BL/6J-+ T(1;2)5Ca/a +/J

000258 C57BL/6J-Aⁱ/a/J

000774 C57BL/6J-A^sy/a/J

000569 C57BL/6J-A^w-J-Eda^Ta +/+ Ar^Tfm/J

000051 C57BL/6J-A^w-J/J

000055 C57BL/6J-a^t-33J/J

000070 C57BL/6J-a^td/J

000284 CWD/LeJ

000670 DBA/1J

000671 DBA/2J

001057 HPT/LeJ

000260 JGBF/LeJ

002468 KK.Cg-A^y/J

000262 LS/LeJ

000265 MY/HuLeJ

000308 SSL/LeJ

001427 STOCK A^w us/J

000994 STOCK a Myo5a^d Mreg^dsu/J

000064 STOCK a Tyrp1^b Si^si/J

002238 STOCK a Tyrp1^b shmy/J

001433 STOCK a skt/J

000579 STOCK a tp/J

000319 STOCK a us/J

002648 STOCK a/a Cln6^nclf/J

000317 STOCK a/a Egfr^wa2/J

000302 STOCK a/a Mitf^Mi-wh +/+ Itpr1^opt/J

000286 STOCK a/a Myo5a^d fd/+ +/J

000206 STOCK a/a Tyr^c-h/J

001432 STOCK a/a Tyrp1^b sks/Tyrp1^b +/J

000281 STOCK a/a ma ft/ma ft/J

000312 STOCK stb + a/+ Fign^fi a/J

000596 STOCK T(2;11)30H/+ x AEJ-a Gdf5^bp-H/J or A/J-a Gdf5^bp-J/J

000970 STOCK T(2;16)28H A/T(2;16)28H a/J

000590 STOCK T(2;4)1Sn a/J

000594 STOCK T(2;8)26H a/T(2;8)26H a Tyrp1⁺/Tyrp1^b/J

000623 TR/DiEiJ

View Strains carrying other alleles of a (157 strains)

Additional Web Information

JAX^® NOTES, Winter 1994; 456. Origin of wa-2 Maintained at The Jackson Laboratory.
JAX^® NOTES, Winter 1995; 460. The Waved-2 (wa2) Mutation, Chromosome 11.

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms
assigned by genotype

Egfr^wa2/Egfr^wa2
B6EiC3Sn a/A-Egfr^wa2 Wnt3a^vt/J
cardiovascular system phenotype

abnormal aortic valve morphology (MGI Ref ID J:60750)

enlarged/thickened aortic valves

skin/coat/nails phenotype

abnormal hair follicle structure/orientation (MGI Ref ID J:16986)

abnormal hair texture (MGI Ref ID J:16986)

touch/vibrissae phenotype

abnormal vibrissa morphology (MGI Ref ID J:16986)

endocrine/exocrine gland phenotype

abnormal lactation (MGI Ref ID J:23326)

reduction of milk within ducts of mammary glands and secretory vacuolation within lobules is less pronounced

abnormal mammary gland morphology (MGI Ref ID J:23326)

small mammary glands and the ratio of gland to adipose tissue is reduced

reproductive system phenotype

abnormal lactation (MGI Ref ID J:23326)

reduction of milk within ducts of mammary glands and secretory vacuolation within lobules is less pronounced

abnormal mammary gland morphology (MGI Ref ID J:23326)

small mammary glands and the ratio of gland to adipose tissue is reduced

Wnt3a^vt/Wnt3a^vt
B6EiC3Sn a/A-Egfr^wa2 Wnt3a^vt/J
skeleton phenotype

cervical vertebral transformation (MGI Ref ID J:69781)

homeotic transformation of cervical vertebra 2 (C2) to C1 is seen in some homzygotes

lumbar vertebral transformation (MGI Ref ID J:69781)

transformation of L6 to sacral vertebra 1 (S1)

sacral vertebral transformation (MGI Ref ID J:69781)

transformation of S4 to S3

thoracic vertebral transformation (MGI Ref ID J:69781)

transformation of thoracic vertebra 9 (T9) to T10

transformation of T13 to lumbar vertebra 1 (L1)

View Research Applications

Research Applications
This mouse can be used to support research in many areas including:
Egfr^wa2 related

Cancer Research
Growth Factors/Receptors/Cytokines

Dermatology Research
Skin and Hair Texture Defects

Developmental Biology Research
Neural Tube Defects

Endocrine Deficiency Research
Skin Defects

Immunology and Inflammation Research
Growth Factors/Receptors/Cytokines

Neurobiology Research
Neural Tube Defects

Wnt3a^vt related

Developmental Biology Research
Neural Tube Defects

Neurobiology Research
Neural Tube Defects

Genes & Alleles

Gene & Allele Information

Allele Symbol		A
Allele Name		wild type
Allele Type		Not Applicable
Gene Symbol and Name		a, nonagouti
Chromosome		2
Gene Common Name(s)		AGSW; AGTI; AGTIL; ASP; As; MGC126092; MGC126093; SHEP9; agouti; agouti signal protein; agouti suppressor;

Allele Symbol		Egfr^wa2
Allele Name		waved 2
Allele Type		Spontaneous
Common Name(s)		wa2;
Strain of Origin		STOCK ac
Gene Symbol and Name		Egfr, epidermal growth factor receptor
Chromosome		11
Gene Common Name(s)		9030024J15Rik; AI552599; ERBB; ERBB1; ErbB-1; Erbb; Errp; HER1; PIG61; RIKEN cDNA 9030024J15 gene; Wa5; avian erythroblastic leukemia viral (v-erb-b) oncogene homolog; avian erythroblastosis oncogene B; expressed sequence AI552599; mENA; wa-2; wa2; waved 2; waved 5;
General Note		Found by Keeler in an ``abnormal corpus callosum'' stock at the Bussey Institution, this mutant is very similar to Tgfa^wa1. Homozygotes can be recognized at 2 to 3 days by their curly whiskers. The first coat is waved but later coats are not. The vibrissae usually remain curled and the guard hairs curved. Some homozygotes have eyelids open at birth (J:13052). Butler and Robertson ascribed the open eyelid condition to an independent gene, which they called squint, but it is probably a pleiotropic effect of Egfr^wa2 (J:15239). The proportions of guard hairs and zigzags are about normal in Egfr^wa2/Egfr^wa2 mice, but the hairs show irregularities and narrowing of the medulla, usually accompanied by thickening of the cortex. Bending occurs between these areas (J:5260). In fusion chimeras between Egfr^wa2/Egfr^wa2 and +/+ mice, waved and normal hairs occur in a patchy distribution, suggesting that Egfr^wa2 acts locally in the hair folliclecells (J:5130). The waved-2 phenotype has been shown to result from a point mutation in the Egfr gene. Expression of EGFR in the outer hair root sheath, along with expression of its TGFA ligand in the inner root sheath, suggests that the waved-1 and waved-2 effects on hair growth may result from failures of signaling by this ligand-receptor system in skin (J:16986). Impairment of lactation in fertile mutant females is another effect of Egfrwa2 (J:23326). Phenotypic Similarity to Human Syndrome: aortic valve disease (J:60750).
Molecular Note		A T-to-G transversion mutation in the sequences encoding the tyrosine kinase domain is predicted to result in a substitution of a glycine for a highly conserved valine at position 743 in the third kinase subdomain. [MGI Ref ID J:16986]

Allele Symbol		Wnt3a^vt
Allele Name		vestigial tail
Allele Type		Spontaneous
Common Name(s)		vt;
Strain of Origin		C57BR
Gene Symbol and Name		Wnt3a, wingless-related MMTV integration site 3A
Chromosome		11
Gene Common Name(s)		MGC119418; MGC119419; MGC119420; Wnt-3a; vestigial tail; vt;
Molecular Note		Examination of the Wnt3a gene by Southern blot, Northern blot on adult lung tissue and cDNA sequence analysis revealed no sign of an obvious mutation that could account for a mutant phenotype. However, this mutation and a targeted mutation, Wnt3a^tm1Amc, were demonstrated to be noncomplemeting alleles. Further evidence from whole mount in situ hybridization studies on embryos demonstrated that expression of the encoded protein is reduced in homozygous embryos, suggesting that this hypomorphicallele results from a mutation in a regulatory element. [MGI Ref ID J:31335]

Genotyping

Genotyping Information

This strain will not have a genotyping protocol or one is not currently available.

Helpful Links

Optimizing PCR Protocols

References

Additional References

Beland M; Pilon N; Houle M; Oh K; Sylvestre JR; Prinos P; Lohnes D. 2004. Cdx1 autoregulation is governed by a novel Cdx1-LEF1 transcription complex. Mol Cell Biol 24(11):5028-38. [PubMed: 15143193] [MGI Ref ID J:91084]

Fitch KR; McGowan KA; Van Raamsdonk CD; Fuchs H; Lee D; Puech A; Herault Y; Threadgill DW; De Angelis MH; Barsh GS. 2003. Genetics of dark skin in mice. Genes Dev 17(2):214-28. [PubMed: 12533510] [MGI Ref ID J:81301]

Greco TL; Takada S; Newhouse MM; McMahon JA; McMahon AP; Camper SA. 1996. Analysis of the vestigial tail mutation demonstrates that Wnt-3a gene dosage regulates mouse axial development. Genes Dev 10(3):313-24. [PubMed: 8595882] [MGI Ref ID J:31335]

Luetteke NC; Phillips HK; Qiu TH; Copeland NG; Earp HS; Jenkins NA; Lee DC. 1994. The mouse waved-2 phenotype results from a point mutation in the EGF receptor tyrosine kinase. Genes Dev 8(4):399-413. [PubMed: 8125255] [MGI Ref ID J:16986]

Prinos P; Joseph S; Oh K; Meyer BI; Gruss P; Lohnes D. 2001. Multiple Pathways Governing Cdx1 Expression during Murine Development. Dev Biol 239(2):257-69. [PubMed: 11784033] [MGI Ref ID J:72581]

Sunnarborg SW; Hinkle CL; Stevenson M; Russell WE; Raska CS; Peschon JJ; Castner BJ; Gerhart MJ; Paxton RJ; Black RA; Lee DC. 2002. Tumor necrosis factor-alpha converting enzyme (TACE) regulates epidermal growth factor receptor ligand availability. J Biol Chem 277(15):12838-45. [PubMed: 11823465] [MGI Ref ID J:75887]

Threadgill DW; Dlugosz AA; Hansen LA; Tennenbaum T; Lichti U; Yee D; LaMantia C; Mourton T; Herrup K; Harris RC; Barnard JA; Yuspa SH; Coffey RJ; Magnuson T. 1995. Targeted disruption of mouse EGF receptor: effect of genetic background on mutant phenotype. Science 269(5221):230-4. [PubMed: 7618084] [MGI Ref ID J:26833]
A related

Czyzyk TA; Sikorski MA; Yang L; McKnight GS. 2008. Disruption of the RIIbeta subunit of PKA reverses the obesity syndrome of Agouti lethal yellow mice. Proc Natl Acad Sci U S A 105(1):276-81. [PubMed: 18172198] [MGI Ref ID J:131039]

Jackson IJ; Budd PS; Keighren M; McKie L. 2007. Humanized MC1R transgenic mice reveal human specific receptor function. Hum Mol Genet 16(19):2341-8. [PubMed: 17652101] [MGI Ref ID J:129904]

Egfr^wa2 related

Aguirre A; Dupree JL; Mangin JM; Gallo V. 2007. A functional role for EGFR signaling in myelination and remyelination. Nat Neurosci 10(8):990-1002. [PubMed: 17618276] [MGI Ref ID J:124200]

Apostolakis EM; Garai J; Lohmann JE; Clark JH; O'Malley BW. 2000. Epidermal growth factor activates reproductive behavior independent of ovarian steroids in female rodents. Mol Endocrinol 14(7):1086-98. [PubMed: 10894157] [MGI Ref ID J:125045]

Bernal NP; Stehr W; Coyle R; Erwin CR; Warner BW. 2006. Epidermal growth factor receptor signaling regulates Bax and Bcl-w expression and apoptotic responses during intestinal adaptation in mice. Gastroenterology 130(2):412-23. [PubMed: 16472596] [MGI Ref ID J:124922]

Butler L; Robertson DA. 1953. A new eye abnormality in the house mouse J Hered 44:13-16. [MGI Ref ID J:15329]

CARTER TC; PHILLIPS RJ. 1953. The sex distribution of waved-2, shaker-2 and Rex in the house mouse. Z Indukt Abstamm Vererbungsl 85(4):564-78. [PubMed: 13170359] [MGI Ref ID J:225]

Chansel D; Ciroldi M; Vandermeersch S; Jackson LF; Gomez AM; Henrion D; Lee DC; Coffman TM; Richard S; Dussaule JC; Tharaux PL. 2006. Heparin binding EGF is necessary for vasospastic response to endothelin. FASEB J 20(11):1936-8. [PubMed: 16877529] [MGI Ref ID J:129734]

Chen B; Bronson RT; Klaman LD; Hampton TG; Wang JF; Green PJ; Magnuson T; Douglas PS; Morgan JP; Neel BG. 2000. Mice mutant for Egfr and Shp2 have defective cardiac semilunar valvulogenesis. Nat Genet 24(3):296-9. [PubMed: 10700187] [MGI Ref ID J:60750]

Ferby I; Reschke M; Kudlacek O; Knyazev P; Pante G; Amann K; Sommergruber W; Kraut N; Ullrich A; Fassler R; Klein R. 2006. Mig6 is a negative regulator of EGF receptor-mediated skin morphogenesis and tumor formation. Nat Med 12(5):568-73. [PubMed: 16648858] [MGI Ref ID J:109556]

Fitch KR; McGowan KA; Van Raamsdonk CD; Fuchs H; Lee D; Puech A; Herault Y; Threadgill DW; De Angelis MH; Barsh GS. 2003. Genetics of dark skin in mice. Genes Dev 17(2):214-28. [PubMed: 12533510] [MGI Ref ID J:81301]

Flamant M; Tharaux PL; Placier S; Henrion D; Coffman T; Chatziantoniou C; Dussaule JC. 2003. Epidermal growth factor receptor trans-activation mediates the tonic and fibrogenic effects of endothelin in the aortic wall of transgenic mice. FASEB J 17(2):327-9. [PubMed: 12475899] [MGI Ref ID J:127931]

Fowler KJ; Walker F; Alexander W; Hibbs ML; Nice EC; Bohmer RM; Mann GB; Thumwood C; Maglitto R; Danks JA; Chetty R; Burgess AW; Dunn AR. 1995. A mutation in the epidermal growth factor receptor in waved-2 mice has a profound effect on receptor biochemistry that results in impaired lactation. Proc Natl Acad Sci U S A 92(5):1465-9. [PubMed: 7533293] [MGI Ref ID J:23326]

Gillgrass A; Cardiff RD; Sharan N; Kannan S; Muller WJ. 2003. Epidermal growth factor receptor-dependent activation of Gab1 is involved in ErbB-2-mediated mammary tumor progression. Oncogene 22(57):9151-5. [PubMed: 14668796] [MGI Ref ID J:87087]

Helmrath MA; Erwin CR; Warner BW. 1997. A defective EGF-receptor in waved-2 mice attenuates intestinal adaptation. J Surg Res 69(1):76-80. [PubMed: 9202650] [MGI Ref ID J:41901]

Hogan ME; King LE Jr; Sundberg JP. 1995. Defects of pelage hairs in 20 mouse mutations. J Invest Dermatol 104(5 Suppl):31S-32S. [PubMed: 7738386] [MGI Ref ID J:25255]

Jackson LF; Qiu TH; Sunnarborg SW; Chang A; Zhang C; Patterson C; Lee DC. 2003. Defective valvulogenesis in HB-EGF and TACE-null mice is associated with aberrant BMP signaling. EMBO J 22(11):2704-16. [PubMed: 12773386] [MGI Ref ID J:83820]

Keegan BP; Sheflin LG; Spaulding SW. 2000. The internalization and endosomal trafficking of the EGF receptor in response to EGF is delayed in the waved-2 mouse liver. Biochem Biophys Res Commun 267(3):881-6. [PubMed: 10673385] [MGI Ref ID J:60172]

Keeler CE. 1935. A second rexoid coat character in the house mouse. J Hered 26:189-191. [MGI Ref ID J:13052]

Lee D; Cross SH; Strunk KE; Morgan JE; Bailey CL; Jackson IJ; Threadgill DW. 2004. Wa5 is a novel ENU-induced antimorphic allele of the epidermal growth factor receptor. Mamm Genome 15(7):525-36. [PubMed: 15366372] [MGI Ref ID J:92308]

Lee D; Pearsall RS; Das S; Dey SK; Godfrey VL; Threadgill DW. 2004. Epiregulin is not essential for development of intestinal tumors but is required for protection from intestinal damage. Mol Cell Biol 24(20):8907-16. [PubMed: 15456865] [MGI Ref ID J:93327]

Ling BC; Wu J; Miller SJ; Monk KR; Shamekh R; Rizvi TA; Decourten-Myers G; Vogel KS; DeClue JE; Ratner N. 2005. Role for the epidermal growth factor receptor in neurofibromatosis-related peripheral nerve tumorigenesis. Cancer Cell 7(1):65-75. [PubMed: 15652750] [MGI Ref ID J:95933]

Luetteke NC; Phillips HK; Qiu TH; Copeland NG; Earp HS; Jenkins NA; Lee DC. 1994. The mouse waved-2 phenotype results from a point mutation in the EGF receptor tyrosine kinase. Genes Dev 8(4):399-413. [PubMed: 8125255] [MGI Ref ID J:16986]

Mak KK; Chan SY. 2003. Epidermal growth factor as a biologic switch in hair growth cycle. J Biol Chem 278(28):26120-6. [PubMed: 12714603] [MGI Ref ID J:84423]

McLaren A. 1971. The microscopic appearance of waved-2 mouse hairs. Genet Res 17(3):257-60. [PubMed: 5142632] [MGI Ref ID J:5260]

McLaren A; Bowman P. 1969. Mouse chimaeras derived from fusion of embryos differing by nine genetic factors. Nature 224(216):238-40. [PubMed: 5344599] [MGI Ref ID J:5130]

Minami S; Iwamoto R; Mekada E. 2008. HB-EGF decelerates cell proliferation synergistically with TGFalpha in perinatal distal lung development. Dev Dyn 237(1):247-58. [PubMed: 18069687] [MGI Ref ID J:130339]

Mine N; Iwamoto R; Mekada E. 2005. HB-EGF promotes epithelial cell migration in eyelid development. Development 132(19):4317-26. [PubMed: 16141218] [MGI Ref ID J:101734]

Mrosovsky N; Redlin U; Roberts RB; Threadgill DW. 2005. Masking in waved-2 mice: EGF receptor control of locomotion questioned. Chronobiol Int 22(6):963-74. [PubMed: 16393701] [MGI Ref ID J:116871]

Ogawa M; Nomura S; Varro A; Wang TC; Goldenring JR. 2006. Altered metaplastic response of waved-2 EGF receptor mutant mice to acute oxyntic atrophy. Am J Physiol Gastrointest Liver Physiol 290(4):G793-804. [PubMed: 16306133] [MGI Ref ID J:106796]

Panigone S; Hsieh M; Fu M; Persani L; Conti M. 2008. Luteinizing hormone signaling in preovulatory follicles involves early activation of the epidermal growth factor receptor pathway. Mol Endocrinol 22(4):924-36. [PubMed: 18187604] [MGI Ref ID J:132998]

Prevot V; Lomniczi A; Corfas G; Ojeda SR. 2005. erbB-1 and erbB-4 receptors act in concert to facilitate female sexual development and mature reproductive function. Endocrinology 146(3):1465-72. [PubMed: 15591145] [MGI Ref ID J:97399]

Qu CK; Yu WM; Azzarelli B; Feng GS. 1999. Genetic evidence that Shp-2 tyrosine phosphatase is a signal enhancer of the epidermal growth factor receptor in mammals. Proc Natl Acad Sci U S A 96(15):8528-33. [PubMed: 10411909] [MGI Ref ID J:75413]

Richards WG; Sweeney WE; Yoder BK; Wilkinson JE; Woychik RP; Avner ED. 1998. Epidermal growth factor receptor activity mediates renal cyst formation in polycystic kidney disease. J Clin Invest 101(5):935-9. [PubMed: 9486961] [MGI Ref ID J:46764]

Roberts RB; Min L; Washington MK; Olsen SJ; Settle SH; Coffey RJ; Threadgill DW. 2002. Importance of epidermal growth factor receptor signaling in establishment of adenomas and maintenance of carcinomas during intestinal tumorigenesis. Proc Natl Acad Sci U S A 99(3):1521-6. [PubMed: 11818567] [MGI Ref ID J:74510]

Sibilia M; Fleischmann A; Behrens A; Stingl L; Carroll J; Watt FM; Schlessinger J; Wagner EF. 2000. The EGF receptor provides an essential survival signal for SOS-dependent skin tumor development Cell 102(2):211-20. [PubMed: 10943841] [MGI Ref ID J:63426]

Sunnarborg SW; Hinkle CL; Stevenson M; Russell WE; Raska CS; Peschon JJ; Castner BJ; Gerhart MJ; Paxton RJ; Black RA; Lee DC. 2002. Tumor necrosis factor-alpha converting enzyme (TACE) regulates epidermal growth factor receptor ligand availability. J Biol Chem 277(15):12838-45. [PubMed: 11823465] [MGI Ref ID J:75887]

Wu J; Crimmins JT; Monk KR; Williams JP; Fitzgerald ME; Tedesco S; Ratner N. 2006. Perinatal epidermal growth factor receptor blockade prevents peripheral nerve disruption in a mouse model reminiscent of benign world health organization grade I neurofibroma. Am J Pathol 168(5):1686-96. [PubMed: 16651634] [MGI Ref ID J:108591]

Yamaoka T; Yan F; Cao H; Hobbs SS; Dise RS; Tong W; Polk DB. 2008. Transactivation of EGF receptor and ErbB2 protects intestinal epithelial cells from TNF-induced apoptosis. Proc Natl Acad Sci U S A 105(33):11772-7. [PubMed: 18701712] [MGI Ref ID J:138989]

Zenz R; Scheuch H; Martin P; Frank C; Eferl R; Kenner L; Sibilia M; Wagner EF. 2003. c-Jun Regulates Eyelid Closure and Skin Tumor Development through EGFR Signaling. Dev Cell 4(6):879-89. [PubMed: 12791272] [MGI Ref ID J:84512]

Wnt3a^vt related

Beland M; Pilon N; Houle M; Oh K; Sylvestre JR; Prinos P; Lohnes D. 2004. Cdx1 autoregulation is governed by a novel Cdx1-LEF1 transcription complex. Mol Cell Biol 24(11):5028-38. [PubMed: 15143193] [MGI Ref ID J:91084]

Chan BW; Chan KS; Koide T; Yeung SM; Leung MB; Copp AJ; Loeken MR; Shiroishi T; Shum AS. 2002. Maternal diabetes increases the risk of caudal regression caused by retinoic acid. Diabetes 51(9):2811-6. [PubMed: 12196475] [MGI Ref ID J:106970]

Dale JK; Malapert P; Chal J; Vilhais-Neto G; Maroto M; Johnson T; Jayasinghe S; Trainor P; Herrmann B; Pourquie O. 2006. Oscillations of the snail genes in the presomitic mesoderm coordinate segmental patterning and morphogenesis in vertebrate somitogenesis. Dev Cell 10(3):355-66. [PubMed: 16516838] [MGI Ref ID J:106622]

Fitch KR; McGowan KA; Van Raamsdonk CD; Fuchs H; Lee D; Puech A; Herault Y; Threadgill DW; De Angelis MH; Barsh GS. 2003. Genetics of dark skin in mice. Genes Dev 17(2):214-28. [PubMed: 12533510] [MGI Ref ID J:81301]

Galceran J; Hsu SC; Grosschedl R. 2001. Rescue of a Wnt mutation by an activated form of LEF-1: regulation of maintenance but not initiation of Brachyury expression. Proc Natl Acad Sci U S A 98(15):8668-73. [PubMed: 11447280] [MGI Ref ID J:133091]

Greco TL; Takada S; Newhouse MM; McMahon JA; McMahon AP; Camper SA. 1996. Analysis of the vestigial tail mutation demonstrates that Wnt-3a gene dosage regulates mouse axial development. Genes Dev 10(3):313-24. [PubMed: 8595882] [MGI Ref ID J:31335]

Gruneberg H. 1957. Genetical studies on the skeleton of the mouse. XIX. Vestigial-tail J Genet 55:181-94. [MGI Ref ID J:14984]

Gruneberg H; Wickramaratne GA. 1974. A re-examination of two skeletal mutants of the mouse, vestigial-tail (vt) and congenital hydrocephalus (ch). J Embryol Exp Morphol 31(1):207-22. [PubMed: 4819561] [MGI Ref ID J:5431]

HESTON WE. 1951. The 'vestigial tail' mouse; a new recessive mutation. J Hered 42(2):71-4. [PubMed: 14832454] [MGI Ref ID J:13062]

Heston WE. 1951. vt - vestigial-tail Mouse News Lett 4:11. [MGI Ref ID J:64271]

Ikeya M; Takada S. 2001. Wnt-3a is required for somite specification along the anteroposterior axis of the mouse embryo and for regulation of cdx-1 expression. Mech Dev 103(1-2):27-33. [PubMed: 11335109] [MGI Ref ID J:69781]

Ishikawa A; Kitajima S; Takahashi Y; Kokubo H; Kanno J; Inoue T; Saga Y. 2004. Mouse Nkd1, a Wnt antagonist, exhibits oscillatory gene expression in the PSM under the control of Notch signaling. Mech Dev 121(12):1443-53. [PubMed: 15511637] [MGI Ref ID J:95048]

Johnson DR. 1976. The interfrontal bone and mutant genes in the mouse. J Anat 121(3):507-13. [PubMed: 1018005] [MGI Ref ID J:5776]

Michie D. 1955. Genetical studies with "vestigial tail" mice. I. The sex difference in crossing-over between vestigial and rex J Genet 53:270-9. [MGI Ref ID J:281]

Michie D. 1955. Genetical studies with "vestigial tail" mice. II. The position of vestigial in the seventh linkage group J Genet 53:280-4. [MGI Ref ID J:282]

Michie D. 1956. Genetical studies with Vestigial Tail mice. IV. The interaction of vestigial with brachyury J Genet 54(1):49-53. [MGI Ref ID J:28462]

Mrosovsky N; Redlin U; Roberts RB; Threadgill DW. 2005. Masking in waved-2 mice: EGF receptor control of locomotion questioned. Chronobiol Int 22(6):963-74. [PubMed: 16393701] [MGI Ref ID J:116871]

Pilon N; Oh K; Sylvestre JR; Bouchard N; Savory J; Lohnes D. 2006. Cdx4 is a direct target of the canonical Wnt pathway. Dev Biol 289(1):55-63. [PubMed: 16309666] [MGI Ref ID J:104169]

Pinson KI; Brennan J; Monkley S; Avery BJ; Skarnes WC. 2000. An LDL-receptor-related protein mediates Wnt signalling in mice Nature 407(6803):535-8. [PubMed: 11029008] [MGI Ref ID J:64989]

Prinos P; Joseph S; Oh K; Meyer BI; Gruss P; Lohnes D. 2001. Multiple Pathways Governing Cdx1 Expression during Murine Development. Dev Biol 239(2):257-69. [PubMed: 11784033] [MGI Ref ID J:72581]

Shum AS; Poon LL; Tang WW; Koide T; Chan BW; Leung YC; Shiroishi T; Copp AJ. 1999. Retinoic acid induces down-regulation of Wnt-3a, apoptosis and diversion of tail bud cells to a neural fate in the mouse embryo. Mech Dev 84(1-2):17-30. [PubMed: 10473117] [MGI Ref ID J:56417]

Wittler L; Shin EH; Grote P; Kispert A; Beckers A; Gossler A; Werber M; Herrmann BG. 2007. Expression of Msgn1 in the presomitic mesoderm is controlled by synergism of WNT signalling and Tbx6. EMBO Rep 8(8):784-9. [PubMed: 17668009] [MGI Ref ID J:129900]

Health & husbandry

Health & Colony Maintenance Information

Currently there no information available for this strain. This may be due to the supply level of this strain.

Purchasing information

Pricing, Supply Level & Notes, Controls, General Terms & Conditions

Pricing

Pricing for USA, Canada and Mexico shipping destinations

Weeks of Age Price* Gender

Cryorecovery Fee $1900.00

*Price(s) in US dollars ($)

Weeks of Age	Price*	Gender
Cryorecovery Fee	$1900.00

Additional Supply Details

Pricing for International shipping destinations

Weeks of Age Price* Gender

Cryorecovery Fee $2470.00

*Price(s) in US dollars ($)

Weeks of Age	Price*	Gender
Cryorecovery Fee	$2470.00

Additional Supply Details

Supply Details

Standard Supply	Repository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information.
Supply Notes	Cryorecovery - Standard. The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two males and two females (two pairs) will be provided, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the delivery time to approximately 25 weeks. At least one member of each pair will be of known genotype and will carry the mutation if it is a mutant strain. Please note that pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Price represents a repository maintenance fee, which includes the cost of recovery of the strain from the cryopreservation resource and the periodic replacement of the frozen embryos used for recovery. *Cryorecovery to establish a Dedicated Supply for greater quantities of mice.* One to two pairs will be recovered to establish a Dedicated Supply of mice. Price by quotation. For more information on Dedicated Supply, please contact JAX^® Services, Tel: 1-800-422-6423 or 1-207-288-5845. This strain is included in the Mouse Mutant Resource collection. Genomic DNA is available for this strain from the Mouse DNA Resource.

Standard Supply

Repository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information.

Supply Notes

Cryorecovery - Standard.
The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two males and two females (two pairs) will be provided, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the delivery time to approximately 25 weeks. At least one member of each pair will be of known genotype and will carry the mutation if it is a mutant strain. Please note that pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Price represents a repository maintenance fee, which includes the cost of recovery of the strain from the cryopreservation resource and the periodic replacement of the frozen embryos used for recovery.
Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
One to two pairs will be recovered to establish a Dedicated Supply of mice. Price by quotation. For more information on Dedicated Supply, please contact JAX^® Services, Tel: 1-800-422-6423 or 1-207-288-5845.
This strain is included in the Mouse Mutant Resource collection.
Genomic DNA is available for this strain from the Mouse DNA Resource.

Control Information

	Control
	Untyped from the colony

Considerations for Choosing Controls
USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains.
International - Control Pricing Information for Genetically Engineered Mutant Strains.

General Terms and Conditions

See Terms of Use

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

Ordering and Purchasing Information

Purchasing Information
JAX^® Mice Orders
Surgical Services

Contact Information
Orders & Technical Support
Tel: 800.422.6423 or 207.288.5845
Fax: 207.288.6150
Technical Support Email Form

Terms of Use

General Terms and Conditions

Contact information

General inquiries

Contracts Administration

phone:	207-288-6470
fax:	207-288-6655

JAX^® Mice & Services Conditions of Use

“Each recipient institution, including its employees and other researchers under its control (RECIPIENT), of mice or services using mice from The Jackson Laboratory (TJL) agrees that such mice, descendants of those mice derived by inbreeding or crossbreeding, including unmodified derivatives of those mice or their descendants (“MICE”) shall not be: (i) used for any purpose other than the internal research of the RECIPIENT, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services with respect to MICE. Acceptance of MICE from TJL shall be deemed agreement by RECIPIENT to these conditions, and departure from these conditions requires The Jackson Laboratory’s prior written authorization.”

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. THE LABORATORY EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of MICE, products or services, The Jackson Laboratory will, at its option, provide credit or replacement for the MICE or product received or the services provided.

No Liability

In no event shall The Jackson Laboratory, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, products or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of The Jackson Laboratory, its agents or employees. In purchasing or receiving MICE, products or services from The Jackson Laboratory, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges The Jackson Laboratory from all such causes of action or damages, and further agrees to defend and indemnify The Jackson Laboratory from any costs or damages arising out of any third party claims.

MICE and biological materials are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to The Jackson Laboratory’s MICE, products and services. In addition, special terms and conditions of sale of certain MICE, products and services may be set forth separately in The Jackson Laboratory web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, products and services by The Jackson Laboratory, and by its licensees and distributors.

Acceptance of delivery of MICE, products or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on The Jackson Laboratory, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, products services by The Jackson Laboratory.

003301	(C57BL/6J x C3H-Eya1^bor)F1/J
002083	B6 x B6EiC3 a/A-T(7;16)235Dn/J
000507	B6 x B6EiC3 a/A-Otc^spf/J
000628	B6.CE-A Amy1^b Amy2^b/J
004200	B6;CBACa A^w-J/A-Npr2^cn-2J/J
000604	B6C3 a/A-T(10;13)199H +/+ Lyst^bg-J/J or Lyst^bg-2J/J
001752	B6CBCa A^w-J/A-T(7;15)9H/J
006450	B6EiC3 a/A-Vss/J
000557	B6EiC3-+ a/Lnp^Ul A/J
000504	B6EiC3Sn a/A-Cacnb4^lh/J
001811	B6EiC3Sn a/A-Otc^spf-ash/J
002343	B6EiC3Sn a/A-Otc^spf/J
001923	B6EiC3Sn a/A-Ts(4¹⁷)2Lws Tim/J
000200	C3FeB6 A/A^w-J-Ank^ank/J
000638	C3FeB6 A/A^w-J-Spnb4^qv-J/J
000283	LT.CAST-A/J
001759	STOCK A Tyr^c Sha/J

000251	AEJ.Cg-a^e +/a Gdf5^bp-H/J
000202	AEJ/Gn-bd/J
000199	AEJ/GnLeJ
000427	B10.CE-H13^b A^w/(30NX)SnJ
000420	B10.LP-H13^b A^w/Sn
000477	B10.PA-Pldn^pa H3^e a^t/SnJ
000419	B10.UW-H3^b we Pax1^un a^t/SnJ
003879	B10;TFLe-a/a T tf/+ tf/J
001538	B6 x B6C3Sn a/A-T(1;9)27H/J
000916	B6 x B6C3Sn a/A-T(5;12)31H/J
000602	B6 x B6C3Sn a/A-T(8;16)17H/J
000593	B6 x B6CBCa A^w-J/A-Grid2^Lc T(2;6)7Ca Mitf^Mi-wh/J
000502	B6 x B6CBCa A^w-J/A-Myo5a^flr Gnb5^flr/J
000599	B6 x B6CBCa A^w-J/A-T(5;13)264Ca Kit^W-v/J
000618	B6 x FSB/GnEi a/a Ctsl^fs/J
000577	B6 x STOCK a Oca2^p Hps5^ru2 Ednrb^s/J
000601	B6 x STOCK a/a T(7;18)50H/J
000592	B6 x STOCK T(2;4)13H a/J
002016	B6(Cg)-A^w-J Eda^Ta-6J Chr Y^B6-Sxr/EiJ
000552	B6-A^w-J-Eda^Ta-6J.Cg-Sxr
001730	B6-A^w-J-Eda^Ta-6J.Cg-Sxr^b Hya^-/J
000841	B6-A^w-J.CBy-Eda^Ta-By/J
001809	B6-A^w-J.Cg-Eda^Ta-6J +/+ Ar^Tfm/J
000600	B6-Gpi1^b x B6CBCa A^w-J/A-T(7;15)9H Gpi1^a/J
000769	B6.C/(HZ18)By-a^t-44J/J
000001	B6.C3 A/a Mgrn1^md/J
000203	B6.C3-A^iy/a/J
001572	B6.C3-a^m-J/J
000017	B6.C3Fe-A^vy/J
005505	B6.Cg-A^y Slc7a11^sut/LmLlp
000021	B6.Cg-A^y/J
100409	B6129PF1/J-A^w-J/A^w
004200	B6;CBACa A^w-J/A-Npr2^cn-2J/J
000785	B6;D2-a Es1^e/J
000505	B6C3 A^w-J/A-Muted^mu/J
000604	B6C3 a/A-T(10;13)199H +/+ Lyst^bg-J/J or Lyst^bg-2J/J
002807	B6C3Fe a/a-Meox2^fla/J
000224	B6C3Fe a/a-Scyl1^mdf/J
001037	B6C3Fe a/a-Agtpbp1^pcd/J
000221	B6C3Fe a/a-Alx4^lst-J/J
002062	B6C3Fe a/a-Atp7a^Mo-8J/J
001756	B6C3Fe a/a-Cacng2^stg/J
001815	B6C3Fe a/a-Col1a2^oim/J
000231	B6C3Fe a/a-Csf1^op/J
000209	B6C3Fe a/a-Dh/J
000211	B6C3Fe a/a-Dst^dt-J/J
000210	B6C3Fe a/a-Edar^dl-J/J
000207	B6C3Fe a/a-Edaradd^cr/J
000182	B6C3Fe a/a-Eef1a2^wst/J
001278	B6C3Fe a/a-Glra1^spd/J
000241	B6C3Fe a/a-Glrb^spa/J
002875	B6C3Fe a/a-Hoxd13^spdh/J
000304	B6C3Fe a/a-Krt71^Ca Scn8a^med-J/J
000226	B6C3Fe a/a-Large^myd/J
000636	B6C3Fe a/a-Lmx1a^dr-J/J
001280	B6C3Fe a/a-Lse/J
001573	B6C3Fe a/a-Mitf^Mi/J
001035	B6C3Fe a/a-Napa^hyh/J
000181	B6C3Fe a/a-Otog^twt/J
000278	B6C3Fe a/a-Papss2^bm Hps1^ep Hps6^ru/J
000205	B6C3Fe a/a-Papss2^bm/J
002078	B6C3Fe a/a-Pcdh15^av-2J/J
000246	B6C3Fe a/a-Pitpna^vb/J
001430	B6C3Fe a/a-Ptch1^mes/J
000506	B6C3Fe a/a-Qk^qk/J
000235	B6C3Fe a/a-Reln^rl/J
000237	B6C3Fe a/a-Rora^sg/J
000290	B6C3Fe a/a-Sox10^Dom/J
000230	B6C3Fe a/a-Tcirg1^oc/J
003612	B6C3Fe a/a-Trak1^hyrt/J
001512	B6C3Fe a/a-Ttn^mdm/J
001607	B6C3Fe a/a-Unc5c^rcm/J
000005	B6C3Fe a/a-Wc/J
000243	B6C3Fe a/a-Wnt1^sw/J
000248	B6C3Fe a/a-Xpl/J
001750	B6C3Fe a/a-Xs^J/J
000624	B6C3Fe a/a-anx/J
003020	B6C3Fe a/a-dep/J
002018	B6C3Fe a/a-din/J
002339	B6C3Fe a/a-nma/J
000240	B6C3Fe a/a-soc/J
000063	B6C3Fe a/a-sy/J
001055	B6C3Fe a/a-tip/J
000245	B6C3Fe a/a-tn/J
000065	B6C3Fe a/a-we Pax1^un a^t/J
000296	B6C3Fe-a/a Hoxa13^Hd Mcoln3^Va-J/J
000019	B6C3Fe-a/a-Itpr1^opt/J
001022	B6C3FeF1/J a/a
000314	B6CBACa A^w-J/A-Eda^Ta/J-XO
000501	B6CBACa A^w-J/A-Aifm1^Hq/J
001046	B6CBACa A^w-J/A-Grid2^Lc/J
000500	B6CBACa A^w-J/A-Gs/J
002703	B6CBACa A^w-J/A-Hydin^hy3/J
000247	B6CBACa A^w-J/A-Kcnj6^wv/J
000287	B6CBACa A^w-J/A-Plp1^jp Eda^Ta/J
000515	B6CBACa A^w-J/A-Sfn^Er/J
000242	B6CBACa A^w-J/A-spc/J
000288	B6CBACa A^w-J/A-we a Mafb^kr/J
001201	B6CBACaF1/J-A^w-J/A
001752	B6CBCa A^w-J/A-T(7;15)9H/J
000971	B6EiC3 a/A-Och/J
000551	B6EiC3 a/A-Tbx15^de-H/J
006450	B6EiC3 a/A-Vss/J
000557	B6EiC3-+ a/Lnp^Ul A/J
000503	B6EiC3Sn a/A-Gy/J
001811	B6EiC3Sn a/A-Otc^spf-ash/J
002343	B6EiC3Sn a/A-Otc^spf/J
000391	B6EiC3Sn a/A-Pax6^Sey-Dey/J
001924	B6EiC3Sn a/A-Ts(17¹⁶)65Dn
001923	B6EiC3Sn a/A-Ts(4¹⁷)2Lws Tim/J
000200	C3FeB6 A/A^w-J-Ank^ank/J
000638	C3FeB6 A/A^w-J-Spnb4^qv-J/J
001203	C3FeB6F1/J A/A^w-J
000225	C3FeLe.B6 a/a-Ptpn6^me/J
008425	C3FeLe.B6-a Trl/J
000198	C3FeLe.B6-a/J
000291	C3FeLe.Cg-a/a Hm Kitl^Sl Krt71^Ca-J/J
001272	C3H/HeSnJ-A^hvy/J
000099	C3HeB/FeJ-A^vy/J
001886	C3HeB/FeJLe a/a-gnd/J
000338	C57BL/6J A^w-J-Eda^Ta-6J/J
000584	C57BL/6J-+ T(1;2)5Ca/a +/J
000258	C57BL/6J-Aⁱ/a/J
000774	C57BL/6J-A^sy/a/J
000569	C57BL/6J-A^w-J-Eda^Ta +/+ Ar^Tfm/J
000051	C57BL/6J-A^w-J/J
000055	C57BL/6J-a^t-33J/J
000070	C57BL/6J-a^td/J
000284	CWD/LeJ
000670	DBA/1J
000671	DBA/2J
001057	HPT/LeJ
000260	JGBF/LeJ
002468	KK.Cg-A^y/J
000262	LS/LeJ
000265	MY/HuLeJ
000308	SSL/LeJ
001427	STOCK A^w us/J
000994	STOCK a Myo5a^d Mreg^dsu/J
000064	STOCK a Tyrp1^b Si^si/J
002238	STOCK a Tyrp1^b shmy/J
001433	STOCK a skt/J
000579	STOCK a tp/J
000319	STOCK a us/J
002648	STOCK a/a Cln6^nclf/J
000317	STOCK a/a Egfr^wa2/J
000302	STOCK a/a Mitf^Mi-wh +/+ Itpr1^opt/J
000286	STOCK a/a Myo5a^d fd/+ +/J
000206	STOCK a/a Tyr^c-h/J
001432	STOCK a/a Tyrp1^b sks/Tyrp1^b +/J
000281	STOCK a/a ma ft/ma ft/J
000312	STOCK stb + a/+ Fign^fi a/J
000596	STOCK T(2;11)30H/+ x AEJ-a Gdf5^bp-H/J or A/J-a Gdf5^bp-J/J
000970	STOCK T(2;16)28H A/T(2;16)28H a/J
000590	STOCK T(2;4)1Sn a/J
000594	STOCK T(2;8)26H a/T(2;8)26H a Tyrp1⁺/Tyrp1^b/J
000623	TR/DiEiJ

Strain Name:

B6EiC3Sn a/A-Egfrwa2 Wnt3avt/J

Stock Number:

000553

Availability:

Repository-Cryopreserved

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Egfrwa2/Egfrwa2

Wnt3avt/Wnt3avt

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B6EiC3Sn a/A-Egfr^wa2 Wnt3a^vt/J

Egfr^wa2/Egfr^wa2

Wnt3a^vt/Wnt3a^vt

JAX^® Mice & Services Conditions of Use