Strain Name:

B6EiC3Sn a/A-Egfrwa2 Wnt3avt/J

Stock Number:

000553

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Availability:

Cryopreserved - Ready for recovery

Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Former Names B6EiC3Sn-a/A-Egfrwa2 Wnt3avt/J    (Changed: 15-DEC-04 )
Type Mutant Stock; Spontaneous Mutation;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Specieslaboratory mouse
GenerationN35F2pN1
Generation Definitions

Appearance
black, wavy coat, tail defects
Related Genotype: a/a Egfrwa2 Wnt3avt/Egfrwa2 Wnt3avt

agouti, wavy coat, tail defects
Related Genotype: A/? Egfrwa2 Wnt3avt/Egfrwa2 Wnt3avt

black, normal coat and tail
Related Genotype: a/ a Egfrwa2 Wnt3avt/+ + or a/a ? ?/+ +

agouti, normal coat and tail
Related Genotype: A/? Egfrwa2Wnt3avt/+ + or A/? ? ?/+ +

Description
Mice homozygous for the spontaneous waved 2 mutation (Egfrwa2) are recognizable at 2 to 3 days by curly whiskers. The first coat is waved but later coats are not; vibrissae usually remain curled and the guard hairs curved. Some homozygotes have eyelids open at birth. Fertile mutant females have impaired lactation. Mice homozygous for the vestigial tail spontaneous mutation (Wnt3avt) have very short tails, few presacral vertebrae, and abnormal formation of the lumbar vertebrae.

Development
The vt mutation in Wnt3a arose spontaneously in the C57BR background.

Control Information

  Control
   Untyped from the colony
 
  Considerations for Choosing Controls

Related Strains

View Strains carrying   A     (18 strains)

Strains carrying   Egfrwa2 allele
000317   STOCK a/a Egfrwa2/J
View Strains carrying   Egfrwa2     (1 strain)

Strains carrying other alleles of Egfr
010575   B6;SJL-Tg(tetO-Egfr*)2-9Jek/J
006926   C57BL/6J-EgfrVel/J
018473   STOCK Egfrtm1.1Tyj/J
002857   STOCK Egfrtm1Mag/J
View Strains carrying other alleles of Egfr     (4 strains)

Strains carrying other alleles of Wnt3a
004581   B6.129S1-Wnt3atm1Amc/J
View Strains carrying other alleles of Wnt3a     (1 strain)

Strains carrying other alleles of a
002655   Mus pahari/EiJ
000251   AEJ.Cg-ae +/a Gdf5bp-H/J
000202   AEJ/Gn-bd/J
000199   AEJ/GnLeJ
000433   B10.C-H3c H13? A/(28NX)SnJ
000427   B10.CE-H13b Aw/(30NX)SnJ
000423   B10.KR-H13? A/SnJ
000420   B10.LP-H13b Aw/Sn
000477   B10.PA-Bloc1s6pa H3e at/SnJ
000419   B10.UW-H3b we Pax1un at/SnJ
003879   B10;TFLe-a/a T Itpr3tf/+ Itpr3tf/J
001538   B6 x B6C3Sn a/A-T(1;9)27H/J
000916   B6 x B6C3Sn a/A-T(5;12)31H/J
000602   B6 x B6C3Sn a/A-T(8;16)17H/J
000593   B6 x B6CBCa Aw-J/A-Grid2Lc T(2;6)7Ca MitfMi-wh/J
000502   B6 x B6CBCa Aw-J/A-Myo5aflr Gnb5flr/J
000599   B6 x B6CBCa Aw-J/A-T(5;13)264Ca KitW-v/J
003759   B6 x B6EiC3Sn a/A-T(10;16)232Dn/J
002071   B6 x B6EiC3Sn a/A-T(11;17)202Dn/J
002113   B6 x B6EiC3Sn a/A-T(11A2;16B3)238Dn/J
002068   B6 x B6EiC3Sn a/A-T(11B1;16B5)233Dn/J
002069   B6 x B6EiC3Sn a/A-T(14E4or5;16B5)225Dn/J
001926   B6 x B6EiC3Sn a/A-T(15;16)198Dn/J
001832   B6 x B6EiC3Sn a/A-T(15E;16B1)60Dn/J
003758   B6 x B6EiC3Sn a/A-T(16C3-4;17A2)65Dn/J
001833   B6 x B6EiC3Sn a/A-T(1C2;16C3)45Dn/J
001903   B6 x B6EiC3Sn a/A-T(6F;18C)57Dn/J
001535   B6 x B6EiC3Sn a/A-T(8A4;12D1)69Dn/J
001831   B6 x B6EiC3Sn a/A-T(8C3;16B5)164Dn/J
000618   B6 x FSB/GnEi a/a Ctslfs/J
000577   B6 x STOCK a Oca2p Hps5ru2 Ednrbs/J
000601   B6 x STOCK a/a T(7;18)50H/J
000592   B6 x STOCK T(2;4)13H a/J
002016   B6(Cg)-Aw-J EdaTa-6J Chr YB6-Sxr/EiJ
000600   B6-Gpi1b x B6CBCa Aw-J/A-T(7;15)9H Gpi1a/J
000769   B6.C/(HZ18)By-at-44J/J
000203   B6.C3-Aiy/a/J
000017   B6.C3-Avy/J
001572   B6.C3-am-J/J
001809   B6.Cg-Aw-J EdaTa-6J +/+ ArTfm/J
000552   B6.Cg-Aw-J EdaTa-6J Sxr
001730   B6.Cg-Aw-J EdaTa-6J Sxrb Hya-/J
000841   B6.Cg-Aw-J EdaTa-By/J
000021   B6.Cg-Ay/J
100409   B6129PF1/J-Aw-J/Aw
014608   B6;129S1-a Kitlsl-24J/GrsrJ
000231   B6;C3Fe a/a-Csf1op/J
004200   B6;CBACa Aw-J/A-Npr2cn-2J/GrsrJ
000785   B6;D2-a Ces1ce/EiJ
000505   B6C3 Aw-J/A-Bloc1s5mu/J
000604   B6C3 a/A-T(10;13)199H +/+ Lystbg-J/J or Lystbg-2J/J
001750   B6C3Fe a/a-Eif3cXs-J/J
002807   B6C3Fe a/a-Meox2fla/J
000506   B6C3Fe a/a-Qkqk-v/J
000224   B6C3Fe a/a-Scyl1mdf/J
003020   B6C3Fe a/a-Zdhhc21dep/J
001037   B6C3Fe a/a-Agtpbp1pcd/J
000221   B6C3Fe a/a-Alx4lst-J/J
002062   B6C3Fe a/a-Atp7aMo-8J/J
001756   B6C3Fe a/a-Cacng2stg/J
001815   B6C3Fe a/a-Col1a2oim/J
000209   B6C3Fe a/a-Dh/J
000211   B6C3Fe a/a-Dstdt-J/J
000210   B6C3Fe a/a-Edardl-J/J
000207   B6C3Fe a/a-Edaraddcr/J
000182   B6C3Fe a/a-Eef1a2wst/J
001278   B6C3Fe a/a-Glra1spd/J
000241   B6C3Fe a/a-Glrbspa/J
002875   B6C3Fe a/a-Hoxd13spdh/J
000304   B6C3Fe a/a-Krt71Ca Scn8amed-J/J
000226   B6C3Fe a/a-Largemyd/J
000636   B6C3Fe a/a-Lmx1adr-J/J
001280   B6C3Fe a/a-Lse/J
001573   B6C3Fe a/a-MitfMi/J
001035   B6C3Fe a/a-Napahyh/J
000181   B6C3Fe a/a-Otogtwt/J
000278   B6C3Fe a/a-Papss2bm Hps1ep Hps6ru/J
000205   B6C3Fe a/a-Papss2bm/J
002078   B6C3Fe a/a-Pcdh15av-2J/J
000246   B6C3Fe a/a-Pitpnavb/J
001430   B6C3Fe a/a-Ptch1mes/J
000235   B6C3Fe a/a-Relnrl/J
000237   B6C3Fe a/a-Rorasg/J
000290   B6C3Fe a/a-Sox10Dom/J
000230   B6C3Fe a/a-Tcirg1oc/J
003612   B6C3Fe a/a-Trak1hyrt/J
001512   B6C3Fe a/a-Ttnmdm/J
001607   B6C3Fe a/a-Unc5crcm/J
000005   B6C3Fe a/a-Wc/J
000243   B6C3Fe a/a-Wnt1sw/J
000248   B6C3Fe a/a-Xpl/J
000624   B6C3Fe a/a-anx/J
008044   B6C3Fe a/a-bpck/J
002018   B6C3Fe a/a-din/J
002339   B6C3Fe a/a-nma/J
000240   B6C3Fe a/a-soc/J
000063   B6C3Fe a/a-sy/J
001055   B6C3Fe a/a-tip/J
000245   B6C3Fe a/a-tn/J
000065   B6C3Fe a/a-we Pax1un at/J
000296   B6C3Fe-a/a Hoxa13Hd Mcoln3Va-J/J
000019   B6C3Fe-a/a-Itpr1opt/J
001022   B6C3FeF1/J a/a
000314   B6CBACa Aw-J/A-EdaTa/J-XO
000501   B6CBACa Aw-J/A-Aifm1Hq/J
001046   B6CBACa Aw-J/A-Grid2Lc/J
000500   B6CBACa Aw-J/A-Gs/J
002703   B6CBACa Aw-J/A-Hydinhy3/J
000247   B6CBACa Aw-J/A-Kcnj6wv/J
000287   B6CBACa Aw-J/A-Plp1jp EdaTa/J
000515   B6CBACa Aw-J/A-SfnEr/J
000242   B6CBACa Aw-J/A-spc/J
000288   B6CBACa Aw-J/A-we a Mafbkr/J
001201   B6CBACaF1/J-Aw-J/A
006450   B6EiC3 a/A-Vss/GrsrJ
000971   B6EiC3 a/A-Och/J
000551   B6EiC3 a/A-Tbx15de-H/J
000557   B6EiC3-+ a/LnpUl A/J
000503   B6EiC3Sn a/A-Gy/J
001811   B6EiC3Sn a/A-Otcspf-ash/J
002343   B6EiC3Sn a/A-Otcspf/J
000391   B6EiC3Sn a/A-Pax6Sey-Dey/J
001923   B6EiC3Sn a/A-Ts(417)2Lws TimT(4;17)3Lws/J
001875   B6EiC3SnF1/J
000638   C3FeB6 A/Aw-J-Sptbn4qv-J/J
000200   C3FeB6 A/Aw-J-Ankank/J
001203   C3FeB6F1/J A/Aw-J
000225   C3FeLe.B6 a/a-Ptpn6me/J
000198   C3FeLe.B6-a/J
000291   C3FeLe.Cg-a/a Hm KitlSl Krt71Ca-J/J
001272   C3H/HeSnJ-Ahvy/J
000099   C3HeB/FeJ-Avy/J
001886   C3HeB/FeJLe a/a-gnd/J
000338   C57BL/6J Aw-J-EdaTa-6J/J
000584   C57BL/6J-+ T(1;2)5Ca/a +/J
000258   C57BL/6J-Ai/a/J
000774   C57BL/6J-Asy/a/J
000569   C57BL/6J-Aw-J-EdaTa +/+ ArTfm/J
000051   C57BL/6J-Aw-J/J
000055   C57BL/6J-at-33J/J
000070   C57BL/6J-atd/J
000284   CWD/LeJ
000670   DBA/1J
000671   DBA/2J
001057   HPT/LeJ
000260   JGBF/LeJ
002468   KK.Cg-Ay/J
000262   LS/LeJ
000265   MY/HuLeJ
000308   SSL/LeJ
001427   STOCK Aw us/J
000994   STOCK a Myo5ad Mregdsu/J
000064   STOCK a Tyrp1b Pmelsi/J
002238   STOCK a Tyrp1b shmy/J
001433   STOCK a skt/J
000579   STOCK a tp/J
000319   STOCK a us/J
002648   STOCK a/a Cln6nclf/J
000317   STOCK a/a Egfrwa2/J
000302   STOCK a/a MitfMi-wh +/+ Itpr1opt/J
000286   STOCK a/a Myo5ad fd/+ +/J
000206   STOCK a/a Tyrc-h/J
001432   STOCK a/a Tyrp1b Ndc1sks/Tyrp1b +/J
000281   STOCK a/a ma Flgft/J
000312   STOCK stb + a/+ Fignfi a/J
000596   STOCK T(2;11)30H/+ x AEJ-a Gdf5bp-H/J or A/J-a Gdf5bp-J/J
000970   STOCK T(2;16)28H A/T(2;16)28H a/J
000590   STOCK T(2;4)1Sn a/J
000594   STOCK T(2;8)26H a/T(2;8)26H a Tyrp1+/Tyrp1b/J
000623   TR/DiEiJ
View Strains carrying other alleles of a     (170 strains)

Additional Web Information

JAX® NOTES, Winter 1994; 456. Origin of wa-2 Maintained at The Jackson Laboratory.
JAX® NOTES, Winter 1995; 460. The Waved-2 (wa2) Mutation, Chromosome 11.

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested.
Lung Cancer   (EGFR)
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

Egfrwa2/Egfrwa2

        B6EiC3Sn a/A-Egfrwa2 Wnt3avt/J
  • cardiovascular system phenotype
  • enlarged aortic valve
    • enlarged/thickened aortic valves   (MGI Ref ID J:60750)
  • thick aortic valve   (MGI Ref ID J:60750)
  • endocrine/exocrine gland phenotype
  • abnormal lactation
    • reduction of milk within ducts of mammary glands and secretory vacuolation within lobules is less pronounced   (MGI Ref ID J:23326)
  • abnormal mammary gland morphology
    • small mammary glands and the ratio of gland to adipose tissue is reduced   (MGI Ref ID J:23326)
  • integument phenotype
  • abnormal hair texture   (MGI Ref ID J:16986)
  • abnormal lactation
    • reduction of milk within ducts of mammary glands and secretory vacuolation within lobules is less pronounced   (MGI Ref ID J:23326)
  • abnormal mammary gland morphology
    • small mammary glands and the ratio of gland to adipose tissue is reduced   (MGI Ref ID J:23326)
  • abnormal vibrissa morphology   (MGI Ref ID J:16986)

Wnt3avt/Wnt3avt

        B6EiC3Sn a/A-Egfrwa2 Wnt3avt/J
  • skeleton phenotype
  • cervical vertebral transformation
    • homeotic transformation of cervical vertebra 2 (C2) to C1 is seen in some homzygotes   (MGI Ref ID J:69781)
  • lumbar vertebral transformation
    • transformation of L6 to sacral vertebra 1 (S1)   (MGI Ref ID J:69781)
  • sacral vertebral transformation
    • transformation of S4 to S3   (MGI Ref ID J:69781)
  • thoracic vertebral transformation
    • transformation of thoracic vertebra 9 (T9) to T10   (MGI Ref ID J:69781)
    • transformation of T13 to lumbar vertebra 1 (L1)   (MGI Ref ID J:69781)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Egfrwa2 related

Cancer Research
Growth Factors/Receptors/Cytokines

Dermatology Research
Skin and Hair Texture Defects

Developmental Biology Research
Neural Tube Defects

Endocrine Deficiency Research
Skin Defects

Immunology, Inflammation and Autoimmunity Research
Growth Factors/Receptors/Cytokines

Neurobiology Research
Neural Tube Defects

Wnt3avt related

Developmental Biology Research
Neural Tube Defects

Neurobiology Research
Neural Tube Defects

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol A
Allele Name wild-type agouti
Allele Type Spontaneous
Common Name(s) dark-bellied agouti;
Strain of Originvarious
Gene Symbol and Name a, nonagouti
Chromosome 2
Gene Common Name(s) AGSW; AGTI; AGTIL; ASP; As; SHEP9; agouti; agouti signal protein; agouti suppressor;
General Note The A allele is usually regarded as a wild-type allele. The C3H and CBA mouse sublines are homozygous for agouti. Hairs are black with a subapical yellow band. This black-yellow-black pattern is referred to as agouti. The general appearance is yellowish brown, slightly lighter on the belly than on the back.
Molecular Note This allele, often referred to as wild-type, comprises a novel 131 amino acid protein encoded in a gene comprising four exons, three coding, spanning 18kb. Unique changes in this gene account for all other alleles that have been molecularly characterized. The expression of this allele is almost always dominant to other alleles of this gene. [MGI Ref ID J:3523]
 
Allele Symbol Egfrwa2
Allele Name waved 2
Allele Type Spontaneous
Common Name(s) wa-2; wa2; waved2;
Strain of OriginSTOCK ac
Gene Symbol and Name Egfr, epidermal growth factor receptor
Chromosome 11
Gene Common Name(s) 9030024J15Rik; AI552599; ERBB; ERBB1; ErbB-1; Erbb; Errb1; Errp; HER1; PIG61; RIKEN cDNA 9030024J15 gene; Wa5; avian erythroblastic leukemia viral (v-erb-b) oncogene homolog; avian erythroblastosis oncogene B; expressed sequence AI552599; mENA; wa-2; wa2; waved 2; waved 5;
General Note Found by Keeler in an ``abnormal corpus callosum'' stock at the Bussey Institution.
Phenotypic Similarity to Human Syndrome: Aortic Valve Disease in homozygous mice in J:60750
Molecular Note A T-to-G transversion mutation in the sequences encoding the tyrosine kinase domain is predicted to result in a substitution of a glycine for a highly conserved valine at position 743 in the third kinase subdomain. [MGI Ref ID J:16986]
 
Allele Symbol Wnt3avt
Allele Name vestigial tail
Allele Type Spontaneous
Common Name(s) vt;
Strain of OriginC57BR
Gene Symbol and Name Wnt3a, wingless-related MMTV integration site 3A
Chromosome 11
Gene Common Name(s) Wnt-3a; vestigial tail; vt;
Molecular Note Examination of the Wnt3a gene by Southern blot, Northern blot on adult lung tissue and cDNA sequence analysis revealed no sign of an obvious mutation that could account for a mutant phenotype. However, this mutation and a targeted mutation, Wnt3atm1Amc, were demonstrated to be noncomplemeting alleles. Further evidence from whole mount in situ hybridization studies on embryos demonstrated that expression of the encoded protein is reduced in homozygous embryos, suggesting that this hypomorphicallele results from a mutation in a regulatory element. [MGI Ref ID J:31335]

Genotyping

Genotyping Information


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Additional References

Beland M; Pilon N; Houle M; Oh K; Sylvestre JR; Prinos P; Lohnes D. 2004. Cdx1 autoregulation is governed by a novel Cdx1-LEF1 transcription complex. Mol Cell Biol 24(11):5028-38. [PubMed: 15143193]  [MGI Ref ID J:91084]

Fitch KR; McGowan KA; Van Raamsdonk CD; Fuchs H; Lee D; Puech A; Herault Y; Threadgill DW; De Angelis MH; Barsh GS. 2003. Genetics of dark skin in mice. Genes Dev 17(2):214-28. [PubMed: 12533510]  [MGI Ref ID J:81301]

Greco TL; Takada S; Newhouse MM; McMahon JA; McMahon AP; Camper SA. 1996. Analysis of the vestigial tail mutation demonstrates that Wnt-3a gene dosage regulates mouse axial development. Genes Dev 10(3):313-24. [PubMed: 8595882]  [MGI Ref ID J:31335]

Luetteke NC; Phillips HK; Qiu TH; Copeland NG; Earp HS; Jenkins NA; Lee DC. 1994. The mouse waved-2 phenotype results from a point mutation in the EGF receptor tyrosine kinase. Genes Dev 8(4):399-413. [PubMed: 8125255]  [MGI Ref ID J:16986]

Prinos P; Joseph S; Oh K; Meyer BI; Gruss P; Lohnes D. 2001. Multiple Pathways Governing Cdx1 Expression during Murine Development. Dev Biol 239(2):257-69. [PubMed: 11784033]  [MGI Ref ID J:72581]

Sunnarborg SW; Hinkle CL; Stevenson M; Russell WE; Raska CS; Peschon JJ; Castner BJ; Gerhart MJ; Paxton RJ; Black RA; Lee DC. 2002. Tumor necrosis factor-alpha converting enzyme (TACE) regulates epidermal growth factor receptor ligand availability. J Biol Chem 277(15):12838-45. [PubMed: 11823465]  [MGI Ref ID J:75887]

Threadgill DW; Dlugosz AA; Hansen LA; Tennenbaum T; Lichti U; Yee D; LaMantia C; Mourton T; Herrup K; Harris RC; Barnard JA; Yuspa SH; Coffey RJ; Magnuson T. 1995. Targeted disruption of mouse EGF receptor: effect of genetic background on mutant phenotype. Science 269(5221):230-4. [PubMed: 7618084]  [MGI Ref ID J:26833]

A related

Blewitt ME; Vickaryous NK; Hemley SJ; Ashe A; Bruxner TJ; Preis JI; Arkell R; Whitelaw E. 2005. An N-ethyl-N-nitrosourea screen for genes involved in variegation in the mouse. Proc Natl Acad Sci U S A 102(21):7629-34. [PubMed: 15890782]  [MGI Ref ID J:99816]

Bultman SJ; Michaud EJ; Woychik RP. 1992. Molecular characterization of the mouse agouti locus. Cell 71(7):1195-204. [PubMed: 1473152]  [MGI Ref ID J:3523]

Bundschuh VG; Madry M. 1988. [atwp mutation in an albino mouse substrain (AB/Hum-1)] Z Versuchstierkd 31(6):249-54. [PubMed: 3227730]  [MGI Ref ID J:16568]

Czyzyk TA; Sikorski MA; Yang L; McKnight GS. 2008. Disruption of the RIIbeta subunit of PKA reverses the obesity syndrome of Agouti lethal yellow mice. Proc Natl Acad Sci U S A 105(1):276-81. [PubMed: 18172198]  [MGI Ref ID J:131039]

Dickie MM. 1969. Mutations at the agouti locus in the mouse. J Hered 60(1):20-5. [PubMed: 5798139]  [MGI Ref ID J:30922]

Dry FW. 1928. The agouti coloration of the mouse (Mus Musculus) and the rat (Mus Norvegicus). J Genet 20:131-144.  [MGI Ref ID J:46318]

Dunn LC. 1945. A New Eye Color Mutant in the Mouse with Asymmetrical Expression. Proc Natl Acad Sci U S A 31(11):343-6. [PubMed: 16578176]  [MGI Ref ID J:13122]

Galbraith DB; Wolff GL; Brewer NL. 1979. Tissue microenvironment and the genetic control of hair pigment patterns in mice Dev Genet 1(2):167-179.  [MGI Ref ID J:156092]

Green EL. 1968. . In: Handbook on Genetically Standardized Jax Mice. The Jackson Laboratory, Bar Harbor, ME.  [MGI Ref ID J:36414]

Guido V; and The Mouse Mutant Resource (MMR) at The Jackson Laboratory. 2002. Two new mutations of white bellied agouti, w-46J and w-47J MGI Direct Data Submission :.  [MGI Ref ID J:77218]

Jackson IJ; Budd PS; Keighren M; McKie L. 2007. Humanized MC1R transgenic mice reveal human specific receptor function. Hum Mol Genet 16(19):2341-8. [PubMed: 17652101]  [MGI Ref ID J:129904]

Kelly EM. 1957. Beige, bg Mouse News Lett 16:36.  [MGI Ref ID J:29744]

Mather K; North SB. 1940. Umbrous: a case of dominance modification in mice. J Genet 40:229-41.  [MGI Ref ID J:280]

MouseBookTM. 2005. Information obtained from MouseBook<sup>TM</sup>, Medical Research Council Mammalian Genetics Unit, Harwell, UK. Unpublished :.  [MGI Ref ID J:169366]

Perry WL; Copeland NG; Jenkins NA. 1994. The molecular basis for dominant yellow agouti coat color mutations. Bioessays 16(10):705-7. [PubMed: 7980472]  [MGI Ref ID J:21244]

Phillips RJS. 1966. A cis-trans position effect at the A locus of the house mouse. Genetics 54(2):485-95. [PubMed: 5968639]  [MGI Ref ID J:5027]

Quevedo WC Jr.; Chase HB. 1958. An analysis of the light mutation of coat color in mice. J Morphol 102:329-345.  [MGI Ref ID J:13094]

Silvers WK. 1979. The Coat Colors of Mice; A Model for Mammalian Gene Action and Interaction. In: The Coat Colors of Mice. Springer-Verlag, New York.  [MGI Ref ID J:78801]

Siracusa LD; Washburn LL; Swing DA; Argeson AC; Jenkins NA; Copeland NG. 1995. Hypervariable yellow (Ahvy), a new murine agouti mutation: Ahvy displays the largest variation in coat color phenotypes of all known agouti alleles. J Hered 86(2):121-8. [PubMed: 7751596]  [MGI Ref ID J:24247]

Egfrwa2 related

Aguirre A; Dupree JL; Mangin JM; Gallo V. 2007. A functional role for EGFR signaling in myelination and remyelination. Nat Neurosci 10(8):990-1002. [PubMed: 17618276]  [MGI Ref ID J:124200]

Aguirre A; Rubio ME; Gallo V. 2010. Notch and EGFR pathway interaction regulates neural stem cell number and self-renewal. Nature 467(7313):323-7. [PubMed: 20844536]  [MGI Ref ID J:164664]

Andric N; Thomas M; Ascoli M. 2010. Transactivation of the epidermal growth factor receptor is involved in the lutropin receptor-mediated down-regulation of ovarian aromatase expression in vivo. Mol Endocrinol 24(3):552-60. [PubMed: 20093417]  [MGI Ref ID J:157693]

Apostolakis EM; Garai J; Lohmann JE; Clark JH; O'Malley BW. 2000. Epidermal growth factor activates reproductive behavior independent of ovarian steroids in female rodents. Mol Endocrinol 14(7):1086-98. [PubMed: 10894157]  [MGI Ref ID J:125045]

Barrick CJ; Roberts RB; Rojas M; Rajamannan NM; Suitt CB; O'Brien KD; Smyth SS; Threadgill DW. 2009. Reduced EGFR causes abnormal valvular differentiation leading to calcific aortic stenosis and left ventricular hypertrophy in C57BL/6J but not 129S1/SvImJ mice. Am J Physiol Heart Circ Physiol 297(1):H65-75. [PubMed: 19448146]  [MGI Ref ID J:151100]

Bernal NP; Stehr W; Coyle R; Erwin CR; Warner BW. 2006. Epidermal growth factor receptor signaling regulates Bax and Bcl-w expression and apoptotic responses during intestinal adaptation in mice. Gastroenterology 130(2):412-23. [PubMed: 16472596]  [MGI Ref ID J:124922]

Blaine SA; Ray KC; Branch KM; Robinson PS; Whitehead RH; Means AL. 2009. Epidermal growth factor receptor regulates pancreatic fibrosis. Am J Physiol Gastrointest Liver Physiol 297(3):G434-41. [PubMed: 19608732]  [MGI Ref ID J:152089]

Butler L; Robertson DA. 1953. A new eye abnormality in the house mouse J Hered 44:13-16.  [MGI Ref ID J:15329]

CARTER TC; PHILLIPS RJ. 1953. The sex distribution of waved-2, shaker-2 and Rex in the house mouse. Z Indukt Abstamm Vererbungsl 85(4):564-78. [PubMed: 13170359]  [MGI Ref ID J:225]

Chansel D; Ciroldi M; Vandermeersch S; Jackson LF; Gomez AM; Henrion D; Lee DC; Coffman TM; Richard S; Dussaule JC; Tharaux PL. 2006. Heparin binding EGF is necessary for vasospastic response to endothelin. FASEB J 20(11):1936-8. [PubMed: 16877529]  [MGI Ref ID J:129734]

Chen B; Bronson RT; Klaman LD; Hampton TG; Wang JF; Green PJ; Magnuson T; Douglas PS; Morgan JP; Neel BG. 2000. Mice mutant for Egfr and Shp2 have defective cardiac semilunar valvulogenesis. Nat Genet 24(3):296-9. [PubMed: 10700187]  [MGI Ref ID J:60750]

Dackor J; Caron KM; Threadgill DW. 2009. Placental and embryonic growth restriction in mice with reduced function epidermal growth factor receptor alleles. Genetics 183(1):207-18. [PubMed: 19564486]  [MGI Ref ID J:153156]

Dube PE; Yan F; Punit S; Girish N; McElroy SJ; Washington MK; Polk DB. 2012. Epidermal growth factor receptor inhibits colitis-associated cancer in mice. J Clin Invest 122(8):2780-92. [PubMed: 22772467]  [MGI Ref ID J:190076]

Ferby I; Reschke M; Kudlacek O; Knyazev P; Pante G; Amann K; Sommergruber W; Kraut N; Ullrich A; Fassler R; Klein R. 2006. Mig6 is a negative regulator of EGF receptor-mediated skin morphogenesis and tumor formation. Nat Med 12(5):568-73. [PubMed: 16648858]  [MGI Ref ID J:109556]

Fitch KR; McGowan KA; Van Raamsdonk CD; Fuchs H; Lee D; Puech A; Herault Y; Threadgill DW; De Angelis MH; Barsh GS. 2003. Genetics of dark skin in mice. Genes Dev 17(2):214-28. [PubMed: 12533510]  [MGI Ref ID J:81301]

Flamant M; Tharaux PL; Placier S; Henrion D; Coffman T; Chatziantoniou C; Dussaule JC. 2003. Epidermal growth factor receptor trans-activation mediates the tonic and fibrogenic effects of endothelin in the aortic wall of transgenic mice. FASEB J 17(2):327-9. [PubMed: 12475899]  [MGI Ref ID J:127931]

Fowler KJ; Walker F; Alexander W; Hibbs ML; Nice EC; Bohmer RM; Mann GB; Thumwood C; Maglitto R; Danks JA; Chetty R; Burgess AW; Dunn AR. 1995. A mutation in the epidermal growth factor receptor in waved-2 mice has a profound effect on receptor biochemistry that results in impaired lactation. Proc Natl Acad Sci U S A 92(5):1465-9. [PubMed: 7533293]  [MGI Ref ID J:23326]

Gillgrass A; Cardiff RD; Sharan N; Kannan S; Muller WJ. 2003. Epidermal growth factor receptor-dependent activation of Gab1 is involved in ErbB-2-mediated mammary tumor progression. Oncogene 22(57):9151-5. [PubMed: 14668796]  [MGI Ref ID J:87087]

Guinea-Viniegra J; Zenz R; Scheuch H; Jimenez M; Bakiri L; Petzelbauer P; Wagner EF. 2012. Differentiation-induced skin cancer suppression by FOS, p53, and TACE/ADAM17. J Clin Invest 122(8):2898-910. [PubMed: 22772468]  [MGI Ref ID J:190075]

He S; Liu N; Bayliss G; Zhuang S. 2013. EGFR activity is required for renal tubular cell dedifferentiation and proliferation in a murine model of folic acid-induced acute kidney injury. Am J Physiol Renal Physiol 304(4):F356-66. [PubMed: 23255615]  [MGI Ref ID J:193168]

Helmrath MA; Erwin CR; Warner BW. 1997. A defective EGF-receptor in waved-2 mice attenuates intestinal adaptation. J Surg Res 69(1):76-80. [PubMed: 9202650]  [MGI Ref ID J:41901]

Hogan ME; King LE Jr; Sundberg JP. 1995. Defects of pelage hairs in 20 mouse mutations. J Invest Dermatol 104(5 Suppl):31S-32S. [PubMed: 7738386]  [MGI Ref ID J:25255]

Ishibe S; Karihaloo A; Ma H; Zhang J; Marlier A; Mitobe M; Togawa A; Schmitt R; Czyczk J; Kashgarian M; Geller DS; Thorgeirsson SS; Cantley LG. 2009. Met and the epidermal growth factor receptor act cooperatively to regulate final nephron number and maintain collecting duct morphology. Development 136(2):337-45. [PubMed: 19103805]  [MGI Ref ID J:143511]

Jackson LF; Qiu TH; Sunnarborg SW; Chang A; Zhang C; Patterson C; Lee DC. 2003. Defective valvulogenesis in HB-EGF and TACE-null mice is associated with aberrant BMP signaling. EMBO J 22(11):2704-16. [PubMed: 12773386]  [MGI Ref ID J:83820]

Keegan BP; Sheflin LG; Spaulding SW. 2000. The internalization and endosomal trafficking of the EGF receptor in response to EGF is delayed in the waved-2 mouse liver. Biochem Biophys Res Commun 267(3):881-6. [PubMed: 10673385]  [MGI Ref ID J:60172]

Keeler CE. 1935. A second rexoid coat character in the house mouse. J Hered 26:189-191.  [MGI Ref ID J:13052]

Lee D; Cross SH; Strunk KE; Morgan JE; Bailey CL; Jackson IJ; Threadgill DW. 2004. Wa5 is a novel ENU-induced antimorphic allele of the epidermal growth factor receptor. Mamm Genome 15(7):525-36. [PubMed: 15366372]  [MGI Ref ID J:92308]

Lee D; Pearsall RS; Das S; Dey SK; Godfrey VL; Threadgill DW. 2004. Epiregulin is not essential for development of intestinal tumors but is required for protection from intestinal damage. Mol Cell Biol 24(20):8907-16. [PubMed: 15456865]  [MGI Ref ID J:93327]

Lichtenberger BM; Tan PK; Niederleithner H; Ferrara N; Petzelbauer P; Sibilia M. 2010. Autocrine VEGF signaling synergizes with EGFR in tumor cells to promote epithelial cancer development. Cell 140(2):268-79. [PubMed: 20141840]  [MGI Ref ID J:156995]

Ling BC; Wu J; Miller SJ; Monk KR; Shamekh R; Rizvi TA; Decourten-Myers G; Vogel KS; DeClue JE; Ratner N. 2005. Role for the epidermal growth factor receptor in neurofibromatosis-related peripheral nerve tumorigenesis. Cancer Cell 7(1):65-75. [PubMed: 15652750]  [MGI Ref ID J:95933]

Liu B; Xia X; Zhu F; Park E; Carbajal S; Kiguchi K; DiGiovanni J; Fischer SM; Hu Y. 2008. IKKalpha is required to maintain skin homeostasis and prevent skin cancer. Cancer Cell 14(3):212-25. [PubMed: 18772111]  [MGI Ref ID J:141162]

Luetteke NC; Phillips HK; Qiu TH; Copeland NG; Earp HS; Jenkins NA; Lee DC. 1994. The mouse waved-2 phenotype results from a point mutation in the EGF receptor tyrosine kinase. Genes Dev 8(4):399-413. [PubMed: 8125255]  [MGI Ref ID J:16986]

Mak KK; Chan SY. 2003. Epidermal growth factor as a biologic switch in hair growth cycle. J Biol Chem 278(28):26120-6. [PubMed: 12714603]  [MGI Ref ID J:84423]

McLaren A. 1971. The microscopic appearance of waved-2 mouse hairs. Genet Res 17(3):257-60. [PubMed: 5142632]  [MGI Ref ID J:5260]

McLaren A; Bowman P. 1969. Mouse chimaeras derived from fusion of embryos differing by nine genetic factors. Nature 224(216):238-40. [PubMed: 5344599]  [MGI Ref ID J:5130]

Minami S; Iwamoto R; Mekada E. 2008. HB-EGF decelerates cell proliferation synergistically with TGFalpha in perinatal distal lung development. Dev Dyn 237(1):247-58. [PubMed: 18069687]  [MGI Ref ID J:130339]

Mine N; Iwamoto R; Mekada E. 2005. HB-EGF promotes epithelial cell migration in eyelid development. Development 132(19):4317-26. [PubMed: 16141218]  [MGI Ref ID J:101734]

Mrosovsky N; Redlin U; Roberts RB; Threadgill DW. 2005. Masking in waved-2 mice: EGF receptor control of locomotion questioned. Chronobiol Int 22(6):963-74. [PubMed: 16393701]  [MGI Ref ID J:116871]

Nakamura M; Schneider MR; Schmidt-Ullrich R; Paus R. 2013. Mutant laboratory mice with abnormalities in hair follicle morphogenesis, cycling, and/or structure: an update. J Dermatol Sci 69(1):6-29. [PubMed: 23165165]  [MGI Ref ID J:196518]

Ogawa M; Nomura S; Varro A; Wang TC; Goldenring JR. 2006. Altered metaplastic response of waved-2 EGF receptor mutant mice to acute oxyntic atrophy. Am J Physiol Gastrointest Liver Physiol 290(4):G793-804. [PubMed: 16306133]  [MGI Ref ID J:106796]

Panigone S; Hsieh M; Fu M; Persani L; Conti M. 2008. Luteinizing hormone signaling in preovulatory follicles involves early activation of the epidermal growth factor receptor pathway. Mol Endocrinol 22(4):924-36. [PubMed: 18187604]  [MGI Ref ID J:132998]

Prevot V; Lomniczi A; Corfas G; Ojeda SR. 2005. erbB-1 and erbB-4 receptors act in concert to facilitate female sexual development and mature reproductive function. Endocrinology 146(3):1465-72. [PubMed: 15591145]  [MGI Ref ID J:97399]

Qu CK; Yu WM; Azzarelli B; Feng GS. 1999. Genetic evidence that Shp-2 tyrosine phosphatase is a signal enhancer of the epidermal growth factor receptor in mammals. Proc Natl Acad Sci U S A 96(15):8528-33. [PubMed: 10411909]  [MGI Ref ID J:75413]

Richards WG; Sweeney WE; Yoder BK; Wilkinson JE; Woychik RP; Avner ED. 1998. Epidermal growth factor receptor activity mediates renal cyst formation in polycystic kidney disease. J Clin Invest 101(5):935-9. [PubMed: 9486961]  [MGI Ref ID J:46764]

Roberts RB; Min L; Washington MK; Olsen SJ; Settle SH; Coffey RJ; Threadgill DW. 2002. Importance of epidermal growth factor receptor signaling in establishment of adenomas and maintenance of carcinomas during intestinal tumorigenesis. Proc Natl Acad Sci U S A 99(3):1521-6. [PubMed: 11818567]  [MGI Ref ID J:74510]

Sibilia M; Fleischmann A; Behrens A; Stingl L; Carroll J; Watt FM; Schlessinger J; Wagner EF. 2000. The EGF receptor provides an essential survival signal for SOS-dependent skin tumor development Cell 102(2):211-20. [PubMed: 10943841]  [MGI Ref ID J:63426]

Sunnarborg SW; Hinkle CL; Stevenson M; Russell WE; Raska CS; Peschon JJ; Castner BJ; Gerhart MJ; Paxton RJ; Black RA; Lee DC. 2002. Tumor necrosis factor-alpha converting enzyme (TACE) regulates epidermal growth factor receptor ligand availability. J Biol Chem 277(15):12838-45. [PubMed: 11823465]  [MGI Ref ID J:75887]

Tang J; Liu N; Tolbert E; Ponnusamy M; Ma L; Gong R; Bayliss G; Yan H; Zhuang S. 2013. Sustained Activation of EGFR Triggers Renal Fibrogenesis after Acute Kidney Injury. Am J Pathol 183(1):160-72. [PubMed: 23684791]  [MGI Ref ID J:199003]

Wang DZ; Hammond VE; Abud HE; Bertoncello I; McAvoy JW; Bowtell DD. 1997. Mutation in Sos1 dominantly enhances a weak allele of the EGFR, demonstrating a requirement for Sos1 in EGFR signaling and development. Genes Dev 11(3):309-20. [PubMed: 9030684]  [MGI Ref ID J:38321]

Winter M; Moser MA; Meunier D; Fischer C; Machat G; Mattes K; Lichtenberger BM; Brunmeir R; Weissmann S; Murko C; Humer C; Meischel T; Brosch G; Matthias P; Sibilia M; Seiser C. 2013. Divergent roles of HDAC1 and HDAC2 in the regulation of epidermal development and tumorigenesis. EMBO J 32(24):3176-91. [PubMed: 24240174]  [MGI Ref ID J:206161]

Wong VW; Stange DE; Page ME; Buczacki S; Wabik A; Itami S; van de Wetering M; Poulsom R; Wright NA; Trotter MW; Watt FM; Winton DJ; Clevers H; Jensen KB. 2012. Lrig1 controls intestinal stem-cell homeostasis by negative regulation of ErbB signalling. Nat Cell Biol 14(4):401-8. [PubMed: 22388892]  [MGI Ref ID J:196030]

Wu J; Crimmins JT; Monk KR; Williams JP; Fitzgerald ME; Tedesco S; Ratner N. 2006. Perinatal epidermal growth factor receptor blockade prevents peripheral nerve disruption in a mouse model reminiscent of benign world health organization grade I neurofibroma. Am J Pathol 168(5):1686-96. [PubMed: 16651634]  [MGI Ref ID J:108591]

Yamaoka T; Yan F; Cao H; Hobbs SS; Dise RS; Tong W; Polk DB. 2008. Transactivation of EGF receptor and ErbB2 protects intestinal epithelial cells from TNF-induced apoptosis. Proc Natl Acad Sci U S A 105(33):11772-7. [PubMed: 18701712]  [MGI Ref ID J:138989]

Zenz R; Scheuch H; Martin P; Frank C; Eferl R; Kenner L; Sibilia M; Wagner EF. 2003. c-Jun Regulates Eyelid Closure and Skin Tumor Development through EGFR Signaling. Dev Cell 4(6):879-89. [PubMed: 12791272]  [MGI Ref ID J:84512]

Zhang Z; Xiao C; Gibson AM; Bass SA; Khurana Hershey GK. 2014. EGFR signaling blunts allergen-induced IL-6 production and Th17 responses in the skin and attenuates development and relapse of atopic dermatitis. J Immunol 192(3):859-66. [PubMed: 24337738]  [MGI Ref ID J:207327]

Zhu H; Dougherty U; Robinson V; Mustafi R; Pekow J; Kupfer S; Li YC; Hart J; Goss K; Fichera A; Joseph L; Bissonnette M. 2011. EGFR signals downregulate tumor suppressors miR-143 and miR-145 in Western diet-promoted murine colon cancer: role of G1 regulators. Mol Cancer Res 9(7):960-75. [PubMed: 21653642]  [MGI Ref ID J:205224]

Wnt3avt related

Barrick CJ; Roberts RB; Rojas M; Rajamannan NM; Suitt CB; O'Brien KD; Smyth SS; Threadgill DW. 2009. Reduced EGFR causes abnormal valvular differentiation leading to calcific aortic stenosis and left ventricular hypertrophy in C57BL/6J but not 129S1/SvImJ mice. Am J Physiol Heart Circ Physiol 297(1):H65-75. [PubMed: 19448146]  [MGI Ref ID J:151100]

Beland M; Pilon N; Houle M; Oh K; Sylvestre JR; Prinos P; Lohnes D. 2004. Cdx1 autoregulation is governed by a novel Cdx1-LEF1 transcription complex. Mol Cell Biol 24(11):5028-38. [PubMed: 15143193]  [MGI Ref ID J:91084]

Camper SA; Greco TL; Newhouse MM; Takada S; McMahon AP. 1994. Wnt-3a is critical for caudal embryonic development Am J Hum Genet 55(Suppl):A238 (Abstr.).  [MGI Ref ID J:25690]

Chan BW; Chan KS; Koide T; Yeung SM; Leung MB; Copp AJ; Loeken MR; Shiroishi T; Shum AS. 2002. Maternal diabetes increases the risk of caudal regression caused by retinoic acid. Diabetes 51(9):2811-6. [PubMed: 12196475]  [MGI Ref ID J:106970]

Dackor J; Caron KM; Threadgill DW. 2009. Placental and embryonic growth restriction in mice with reduced function epidermal growth factor receptor alleles. Genetics 183(1):207-18. [PubMed: 19564486]  [MGI Ref ID J:153156]

Dale JK; Malapert P; Chal J; Vilhais-Neto G; Maroto M; Johnson T; Jayasinghe S; Trainor P; Herrmann B; Pourquie O. 2006. Oscillations of the snail genes in the presomitic mesoderm coordinate segmental patterning and morphogenesis in vertebrate somitogenesis. Dev Cell 10(3):355-66. [PubMed: 16516838]  [MGI Ref ID J:106622]

Fitch KR; McGowan KA; Van Raamsdonk CD; Fuchs H; Lee D; Puech A; Herault Y; Threadgill DW; De Angelis MH; Barsh GS. 2003. Genetics of dark skin in mice. Genes Dev 17(2):214-28. [PubMed: 12533510]  [MGI Ref ID J:81301]

Galceran J; Hsu SC; Grosschedl R. 2001. Rescue of a Wnt mutation by an activated form of LEF-1: regulation of maintenance but not initiation of Brachyury expression. Proc Natl Acad Sci U S A 98(15):8668-73. [PubMed: 11447280]  [MGI Ref ID J:133091]

Greco TL; Takada S; Newhouse MM; McMahon JA; McMahon AP; Camper SA. 1996. Analysis of the vestigial tail mutation demonstrates that Wnt-3a gene dosage regulates mouse axial development. Genes Dev 10(3):313-24. [PubMed: 8595882]  [MGI Ref ID J:31335]

Gruneberg H. 1957. Genetical studies on the skeleton of the mouse. XIX. Vestigial-tail J Genet 55:181-94.  [MGI Ref ID J:14984]

Gruneberg H; Wickramaratne GA. 1974. A re-examination of two skeletal mutants of the mouse, vestigial-tail (vt) and congenital hydrocephalus (ch). J Embryol Exp Morphol 31(1):207-22. [PubMed: 4819561]  [MGI Ref ID J:5431]

HESTON WE. 1951. The 'vestigial tail' mouse; a new recessive mutation. J Hered 42(2):71-4. [PubMed: 14832454]  [MGI Ref ID J:13062]

Heston WE. 1951. vt - vestigial-tail Mouse News Lett 4:11.  [MGI Ref ID J:64271]

Ikeya M; Takada S. 2001. Wnt-3a is required for somite specification along the anteroposterior axis of the mouse embryo and for regulation of cdx-1 expression. Mech Dev 103(1-2):27-33. [PubMed: 11335109]  [MGI Ref ID J:69781]

Ishikawa A; Kitajima S; Takahashi Y; Kokubo H; Kanno J; Inoue T; Saga Y. 2004. Mouse Nkd1, a Wnt antagonist, exhibits oscillatory gene expression in the PSM under the control of Notch signaling. Mech Dev 121(12):1443-53. [PubMed: 15511637]  [MGI Ref ID J:95048]

Johnson DR. 1976. The interfrontal bone and mutant genes in the mouse. J Anat 121(3):507-13. [PubMed: 1018005]  [MGI Ref ID J:5776]

Lopez TP; Fan CM. 2013. Dynamic CREB family activity drives segmentation and posterior polarity specification in mammalian somitogenesis. Proc Natl Acad Sci U S A 110(22):E2019-27. [PubMed: 23671110]  [MGI Ref ID J:197427]

Michie D. 1955. Genetical studies with "vestigial tail" mice. I. The sex difference in crossing-over between vestigial and rex J Genet 53:270-9.  [MGI Ref ID J:281]

Michie D. 1955. Genetical studies with "vestigial tail" mice. II. The position of vestigial in the seventh linkage group J Genet 53:280-4.  [MGI Ref ID J:282]

Michie D. 1956. Genetical studies with Vestigial Tail mice. IV. The interaction of vestigial with brachyury J Genet 54(1):49-53.  [MGI Ref ID J:28462]

Mrosovsky N; Redlin U; Roberts RB; Threadgill DW. 2005. Masking in waved-2 mice: EGF receptor control of locomotion questioned. Chronobiol Int 22(6):963-74. [PubMed: 16393701]  [MGI Ref ID J:116871]

Pilon N; Oh K; Sylvestre JR; Bouchard N; Savory J; Lohnes D. 2006. Cdx4 is a direct target of the canonical Wnt pathway. Dev Biol 289(1):55-63. [PubMed: 16309666]  [MGI Ref ID J:104169]

Pinson KI; Brennan J; Monkley S; Avery BJ; Skarnes WC. 2000. An LDL-receptor-related protein mediates Wnt signalling in mice Nature 407(6803):535-8. [PubMed: 11029008]  [MGI Ref ID J:64989]

Prinos P; Joseph S; Oh K; Meyer BI; Gruss P; Lohnes D. 2001. Multiple Pathways Governing Cdx1 Expression during Murine Development. Dev Biol 239(2):257-69. [PubMed: 11784033]  [MGI Ref ID J:72581]

Shum AS; Poon LL; Tang WW; Koide T; Chan BW; Leung YC; Shiroishi T; Copp AJ. 1999. Retinoic acid induces down-regulation of Wnt-3a, apoptosis and diversion of tail bud cells to a neural fate in the mouse embryo. Mech Dev 84(1-2):17-30. [PubMed: 10473117]  [MGI Ref ID J:56417]

Wittler L; Shin EH; Grote P; Kispert A; Beckers A; Gossler A; Werber M; Herrmann BG. 2007. Expression of Msgn1 in the presomitic mesoderm is controlled by synergism of WNT signalling and Tbx6. EMBO Rep 8(8):784-9. [PubMed: 17668009]  [MGI Ref ID J:129900]

Health & husbandry

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Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

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Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $2085.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

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Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

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  • Cryorecovery - Standard.
    Progeny testing is not required.
    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 11 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice
    Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $2710.50
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.
    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 11 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice
    Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

General Supply Notes

  • View the complete collection of spontaneous mutants in the Mouse Mutant Resource.

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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


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