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Former Names B6EiC3-+ a/HoxdUl A/J (Changed: 15-DEC-04 ) Type Mutant Stock; Spontaneous Mutation; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Species laboratory mouse Generation N14p Appearance
agouti, unaffected
Related Genotype: A +/? +
agouti, limb abnormality
Related Genotype: A LnpUl/? +
black, unaffected
Related Genotype: a +/a +
black, limb abnormality
Related Genotype: a LnpUl/a +Development
The ulnaless mutation was identified in the progeny of an HT linkage testing stock female (homozygous for a, Gdf5bp Sqk3fz Mlphln Pldnpa and Ap3b1pe) bred with a (C3H/HeJ x 101/H)F1 male that had received two 500 rad doses of X-rays 24 hours apart. This mutation was then maintained by breeding a heterozygote to a (C3H/HeJ x 101/H)F1, and was imported from Harwell into The Jackson Laboratory by Dr. Eva Eicher after 1968 and prior to 1970. At some point in the 1970?s it was maintained by breeding female heterozygotes to (C57BL/6J x CsH/HeJ)F1 males, such that in 1986 it reached generation N20. In 1984 embryos were generated for cryopreservation by breeding female heterozygotes at generation N13 with C57BL/6JEi males.
| Control | ||
|---|---|---|
| Wild-type from the colony | ||
| Considerations for Choosing Controls | ||
Strains carrying A allele
003301 (C57BL/6J x C3H-Eya1bor)F1/J 002083 B6 x B6EiC3 a/A-T(7;16)235Dn/J 000507 B6 x B6EiC3 a/A-Otcspf/J 000628 B6.CE-A Amy1b Amy2a5b/J 004200 B6;CBACa Aw-J/A-Npr2cn-2J/GrsrJ 000604 B6C3 a/A-T(10;13)199H +/+ Lystbg-J/J or Lystbg-2J/J 001752 B6CBCa Aw-J/A-T(7;15)9H/J 006450 B6EiC3 a/A-Vss/GrsrJ 000504 B6EiC3Sn a/A-Cacnb4lh/J 000553 B6EiC3Sn a/A-Egfrwa2 Wnt3avt/J 001811 B6EiC3Sn a/A-Otcspf-ash/J 002343 B6EiC3Sn a/A-Otcspf/J 001923 B6EiC3Sn a/A-Ts(417)2Lws TimT(4;17)3Lws/J 000200 C3FeB6 A/Aw-J-Ankank/J 000638 C3FeB6 A/Aw-J-Spnb4qv-J/J 000283 LT.CAST-A/J 001759 STOCK A Tyrc Sha/J View Strains carrying A (17 strains)
Strains carrying a allele
View Strains carrying a (104 strains)
Strains carrying other alleles of a
View Strains carrying other alleles of a (67 strains)
View Mammalian Phenotype Terms
Mammalian Phenotype Terms
assigned by genotype
LnpUl/Lnp+
B6EiC3-+ a/LnpUl A/J
- homeostasis/metabolism phenotype
- increased bleeding time (MGI Ref ID J:31800)
- bleeding time is increased 2.6- to 3-fold compared to controls
- however platelet numbers and function appear normal
The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.
LnpUl/Lnp+
involves: 101/H * C3H/HeJ
- limbs/digits/tail phenotype
- abnormal fibula morphology (MGI Ref ID J:13461)
- deformities
- abnormal tibia morphology (MGI Ref ID J:13461)
- deformities
- short radius (MGI Ref ID J:13461)
- extreme reduction
- short ulna (MGI Ref ID J:13461)
- extreme reduction
- skeleton phenotype
- abnormal fibula morphology (MGI Ref ID J:13461)
- deformities
- abnormal tibia morphology (MGI Ref ID J:13461)
- deformities
- short radius (MGI Ref ID J:13461)
- extreme reduction
- short ulna (MGI Ref ID J:13461)
- extreme reduction
- reproductive system phenotype
- male infertility (MGI Ref ID J:13461)
- males do not breed
LnpUl/Lnp+
involves: 101/H * C3H/HeJ * C57BL/6J
- limbs/digits/tail phenotype
- abnormal fibula morphology (MGI Ref ID J:10491)
- rotated 90 degrees
- detached from tibia
- short fibula (MGI Ref ID J:10491)
- abnormal metacarpal bone morphology (MGI Ref ID J:10491)
- articulations to distal ends of long bones are abnormal
- abnormal metatarsal bone morphology (MGI Ref ID J:10491)
- articulations to distal ends of long bones are abnormal
- abnormal tibia morphology (MGI Ref ID J:10491)
- rotated 90 degrees
- bowed tibia (MGI Ref ID J:10491)
- short radius (MGI Ref ID J:10491)
- extreme reduction
- short ulna (MGI Ref ID J:10491)
- extreme reduction
- skeleton phenotype
- abnormal fibula morphology (MGI Ref ID J:10491)
- rotated 90 degrees
- detached from tibia
- short fibula (MGI Ref ID J:10491)
- abnormal metacarpal bone morphology (MGI Ref ID J:10491)
- articulations to distal ends of long bones are abnormal
- abnormal metatarsal bone morphology (MGI Ref ID J:10491)
- articulations to distal ends of long bones are abnormal
- abnormal tibia morphology (MGI Ref ID J:10491)
- rotated 90 degrees
- bowed tibia (MGI Ref ID J:10491)
- short radius (MGI Ref ID J:10491)
- extreme reduction
- short ulna (MGI Ref ID J:10491)
- extreme reduction
- reproductive system phenotype
- male infertility (MGI Ref ID J:10491)
- males do not breed although females breed well
- spermatogenesis unimpaired
LnpUl/Lnp+
involves: C3H/HeJ * C57BL/6J * FVB/N
- lethality-postnatal
- postnatal lethality (MGI Ref ID J:37225)
- at weaning there are fewer heterozygotes, both male and female, than expeted from heterozygote x FVB/N matings on a predominantly FVB/N background, but not on a predominantly MOLF/Ei background
LnpUl/LnpUl
involves: C3H/HeJ * C57BL/6J * FVB/N
- limbs/digits/tail phenotype
- abnormal limb morphology (MGI Ref ID J:37225)
- homozygotes have a more severe reduction of the ulna and radius than heterozygotes and there is a severe loss of the fibula and severe reduction and bowing of the tibia
- bowed tibia (MGI Ref ID J:37225)
- short fibula (MGI Ref ID J:37225)
- short radius (MGI Ref ID J:37225)
- short tibia (MGI Ref ID J:37225)
- short ulna (MGI Ref ID J:37225)
- skeleton phenotype
- bowed tibia (MGI Ref ID J:37225)
- delayed bone ossification (MGI Ref ID J:37225)
- the ossification centers of the ulna and fibula are absent in homozygous neonates
- short fibula (MGI Ref ID J:37225)
- short radius (MGI Ref ID J:37225)
- short tibia (MGI Ref ID J:37225)
- short ulna (MGI Ref ID J:37225)
- lethality-postnatal
- postnatal lethality (MGI Ref ID J:37225)
- although the anticipated 1:2:1 Mendelian ratio is obtained at birth from heterozygous intercrosses, very few homozygotes are found at wean age on this predominantly FVB/N background, and those that do survive are male, but this loss of homozygotes is not gound on a predominantly MOLF/Ei background
LnpUl/LnpUl
involves: C3H/HeJ * C57BL/6J * MOLF/Ei
- limbs/digits/tail phenotype
- abnormal limb morphology (MGI Ref ID J:37225)
- homozygotes have a more severe reduction of the ulna and radius than heterozygotes and there is a severe loss of the fibula and severe reduction and bowing of the tibia
- bowed tibia (MGI Ref ID J:37225)
- short fibula (MGI Ref ID J:37225)
- short radius (MGI Ref ID J:37225)
- short tibia (MGI Ref ID J:37225)
- short ulna (MGI Ref ID J:37225)
- skeleton phenotype
- bowed tibia (MGI Ref ID J:37225)
- delayed bone ossification (MGI Ref ID J:37225)
- the ossification centers of the ulna and fibula are absent in homozygous neonates
- short fibula (MGI Ref ID J:37225)
- short radius (MGI Ref ID J:37225)
- short tibia (MGI Ref ID J:37225)
- short ulna (MGI Ref ID J:37225)
View Research Applications
Research Applications
This mouse can be used to support research in many areas including:LnpUl related
Developmental Biology Research
Skeletal Defects
| Allele Symbol | A | ||
|---|---|---|---|
| Allele Name | wild type agouti | ||
| Allele Type | Spontaneous | ||
| Common Name(s) | dark-bellied agouti; | ||
| Strain of Origin | various | ||
| Gene Symbol and Name | a, nonagouti | ||
| Chromosome | 2 | ||
| Gene Common Name(s) | AGSW; AGTI; AGTIL; ASP; As; MGC126092; MGC126093; SHEP9; agouti; agouti signal protein; agouti suppressor; | ||
| General Note | The A allele is usually regarded as a wild-type allele. Hairs are black with a subapical yellow band. This black-yellow-black pattern is referred to as agouti. The general appearance is yellowish brown, slightly lighter on the belly than on the back. | ||
| Molecular Note | This allele, often referred to as wild-type, comprises a novel 131 amino acid protein encoded in a gene comprising four exons, three coding, spanning 18kb. Unique changes in this gene account for all other alleles that have been molecularly characterized. The expression of this allele is almost always dominant to other alleles of this gene. [MGI Ref ID J:3523] | ||
| Allele Symbol | LnpUl | ||
| Allele Name | ulnaless | ||
| Allele Type | Radiation induced | ||
| Common Name(s) | Ul; | ||
| Strain of Origin | (C3H/HeJ x 101/H)F1 | ||
| Gene Symbol and Name | Lnp, limb and neural patterns | ||
| Chromosome | 2 | ||
| Gene Common Name(s) | 2310011O18Rik; 4921514L11Rik; 9530051D01Rik; AI666268; DKFZp686G1442; MGC102862; RIKEN cDNA 2310011O18 gene; RIKEN cDNA 4921514L11 gene; RIKEN cDNA 9530051D01 gene; Ul; expressed sequence AI666268; lunapark; ulnaless; | ||
| Molecular Note | The ulnaless mouse has been characterized as a paracentric inversion with a centromeric breakpoint into the lunapark gene and a telomeric breakpoint 770 kb away. This inversion disrupts the lunapark gene and increases the distance between the neighboringHoxD cluster and a cluster of enhancer sequences controlling several distinct genes over a large region. Genes Evx2, Hoxd12 and Hoxd13 are all misexpressed in the limb buds and genital buds of the ulnaless mouse. The inverted DNA includes Evx2, the HoxD complex, Mtx2, as well as some pseudogenes. [MGI Ref ID J:83372] | ||
| Allele Symbol | a | ||
| Allele Name | nonagouti | ||
| Allele Type | Spontaneous | ||
This strain will not have a genotyping protocol or one is not currently available.
Helpful Links
Genotyping resources and troubleshooting
Spitz F; Gonzalez F; Duboule D. 2003. A global control region defines a chromosomal regulatory landscape containing the HoxD cluster. Cell 113(3):405-17. [PubMed: 12732147] [MGI Ref ID J:83372]
A relatedLnpUl relatedBlewitt ME; Vickaryous NK; Hemley SJ; Ashe A; Bruxner TJ; Preis JI; Arkell R; Whitelaw E. 2005. An N-ethyl-N-nitrosourea screen for genes involved in variegation in the mouse. Proc Natl Acad Sci U S A 102(21):7629-34. [PubMed: 15890782] [MGI Ref ID J:99816]
Bultman SJ; Michaud EJ; Woychik RP. 1992. Molecular characterization of the mouse agouti locus. Cell 71(7):1195-204. [PubMed: 1473152] [MGI Ref ID J:3523]
Bundschuh VG; Madry M. 1988. [atwp mutation in an albino mouse substrain (AB/Hum-1)] Z Versuchstierkd 31(6):249-54. [PubMed: 3227730] [MGI Ref ID J:16568]
Czyzyk TA; Sikorski MA; Yang L; McKnight GS. 2008. Disruption of the RIIbeta subunit of PKA reverses the obesity syndrome of Agouti lethal yellow mice. Proc Natl Acad Sci U S A 105(1):276-81. [PubMed: 18172198] [MGI Ref ID J:131039]
Dickie MM. 1969. Mutations at the agouti locus in the mouse. J Hered 60(1):20-5. [PubMed: 5798139] [MGI Ref ID J:30922]
Dry FW. 1928. The agouti coloration of the mouse (Mus Musculus) and the rat (Mus Norvegicus). J Genet 20:131-144. [MGI Ref ID J:46318]
Guido V, and The Mouse Mutant Resource (MMR) at The Jackson Laboratory. 2002. Two new mutations of white bellied agouti, w-46J and w-47J MGI Direct Data Submission :. [MGI Ref ID J:77218]
Jackson IJ; Budd PS; Keighren M; McKie L. 2007. Humanized MC1R transgenic mice reveal human specific receptor function. Hum Mol Genet 16(19):2341-8. [PubMed: 17652101] [MGI Ref ID J:129904]
Mather K; North SB. 1940. Umbrous: a case of dominance modification in mice. J Genet 40:229-41. [MGI Ref ID J:280]
Perry WL; Copeland NG; Jenkins NA. 1994. The molecular basis for dominant yellow agouti coat color mutations. Bioessays 16(10):705-7. [PubMed: 7980472] [MGI Ref ID J:21244]
Quevedo WC Jr.; Chase HB. 1958. An analysis of the light mutation of coat color in mice. J Morphol 102:329-345. [MGI Ref ID J:13094]
Silvers WK. 1979. The Coat Colors of Mice; A Model for Mammalian Gene Action and Interaction. In: The Coat Colors of Mice. Springer-Verlag, New York. [MGI Ref ID J:78801]
Davisson MT; Cattanach BM. 1990. The mouse mutation ulnaless on chromosome 2. J Hered 81(2):151-3. [PubMed: 2338491] [MGI Ref ID J:10491]
Herault Y; Fraudeau N; Zakany J; Duboule D. 1997. Ulnaless (Ul), a regulatory mutation inducing both loss-of-function and gain-of-function of posterior Hoxd genes. Development 124(18):3493-500. [PubMed: 9342042] [MGI Ref ID J:43310]
Morris T. 1967. Ul. Mouse News Lett 36:34. [MGI Ref ID J:13461]
Peichel CL; Abbott CM; Vogt TF. 1996. Genetic and physical mapping of the mouse Ulnaless locus. Genetics 144(4):1757-67. [PubMed: 8978061] [MGI Ref ID J:37225]
Peichel CL; Prabhakaran B; Vogt TF. 1997. The mouse Ulnaless mutation deregulates posterior HoxD gene expression and alters appendicular patterning. Development 124(18):3481-92. [PubMed: 9342041] [MGI Ref ID J:43311]
Rusiniak ME; O'Brien EP; Novak EK; Barone SM; McGarry MP; Reddington M; Swank RT. 1996. Molecular markers near the mouse brachymorphic (bm) gene, which affects connective tissues and bleeding time. Mamm Genome 7(2):98-102. [PubMed: 8835524] [MGI Ref ID J:31800]
Spitz F; Gonzalez F; Duboule D. 2003. A global control region defines a chromosomal regulatory landscape containing the HoxD cluster. Cell 113(3):405-17. [PubMed: 12732147] [MGI Ref ID J:83372]
Currently there no information available for this strain. This may be due to the supply level of this strain.
| Pricing for USA, Canada and Mexico shipping destinations |
|
Animals Provided
Price (US dollars $) Cryorecovery Fee $1900.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
| Pricing for International shipping destinations |
|
Animals Provided
Price (US dollars $) Cryorecovery Fee $2470.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
| Standard Supply | Cryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information. |
|---|---|
| Supply Notes |
|
| Control | ||
|---|---|---|
| Wild-type from the colony | ||
| Considerations for Choosing Controls | ||
| USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
| International - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
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Fax: 1-207-288-6150
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| phone: | 207-288-6470 |
| fax: | 207-288-6655 |
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