Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Former Names C57BL/6J-jc/J    (Changed: 28-AUG-08 ) Type Coisogenic; Mutant Strain; Spontaneous Mutation; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Species laboratory mouse Generation N17 Generation Definitions

Appearance
black, circling
Related Genotype: a/a jc/jc

black, unaffected
Related Genotype: a/a jc/+

Description
Mice homozygous for the Jackson circler spontaneous mutation (Sobp^jc) show erratic circling behavior which becomes more pronounced with age. Homozygous mutant mice are very active, bobbing up and down and flexing head and trunk ventrally towards the tail and mice can swim. Mice can be identified at weaning by a characteristic flexing behavior when suspended by tail.

Control Information

	Control
	Heterozygote from the colony
Considerations for Choosing Controls

Related Strains

Strains carrying other alleles of Sobp

005292

B6(129S2)-Sobpjc-2J/J

View Strains carrying other alleles of Sobp     (1 strain)

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI

      assigned by genotype

Sobp^jc/Sobp^jc

        C57BL/6J-Sobp^jc/J

• behavior/neurological phenotype
• abnormal motor capabilities/coordination/movement
  • when suspended by the tail, mice are very active, bobbing up and down and flexing the head and trunk ventrally   (MGI Ref ID J:13506)
• • circling   (MGI Ref ID J:116914)
    • circling becomes more erratic with age and is erratic   (MGI Ref ID J:13506)
  • • bidirectional circling
      • mice perform (mean values) 397 clockwise (CR) and 478 counterclockwise (CCR) rotations per hour compared to 50 CR and 45 CCR in heterozygotes   (MGI Ref ID J:113021)
      • circling behavior is similar to other waltzing mutants   (MGI Ref ID J:113021)
  • hyperactivity
    • mice, aged 6 weeks and older, spend 1480 seconds/hour in non-stereotypic behavior compared to 576 sec/hour in littermated controls; phenotype is apparent around 3 weeks of age   (MGI Ref ID J:113021)
    • hyperactive behavior is significantly different from control strains and wild-derived strains which spent between 325 and 876 seconds/hour in ambulation   (MGI Ref ID J:113021)
    • distance covered in a 1 hour period is 409 meters, significantly different from heterozygous littermates and inbred strain controls   (MGI Ref ID J:113021)
• hearing/vestibular/ear phenotype
• abnormal cochlea morphology
  • aberrant structure forms at the apex of cochlea by E15.5   (MGI Ref ID J:113021)
  • at P21, apical turn of cochlea is absent   (MGI Ref ID J:113021)
• • short scala media
    • growth of cochlear duct appears to arrest at E13.5; truncation is more pronounced at E15.5   (MGI Ref ID J:113021)
• absent distortion product otoacoustic emissions
  • mice have no measurable distortion-product otoacoustic emissions (DPOAEs) at 3 primary-tone levels while heterozygotes fall in normal range for all levels   (MGI Ref ID J:113021)
• absent linear vestibular evoked potential
  • VESPs are absent at the maximum stimulus intensity used   (MGI Ref ID J:116914)
• decreased brainstem auditory evoked potential
  • auditory brainstem responses (ABR) measurements show that mutants only respond at high sound pressure levels only   (MGI Ref ID J:113021)
  • mice do not show progressive hearing loss; auditory threshold is not age-dependent   (MGI Ref ID J:113021)
  • auditory threshold is significantly increased compared to mutants on mixed backgrounds   (MGI Ref ID J:113021)

View Research Applications

Research Applications

This mouse can be used to support research in many areas including:

Sobp^jc related

Neurobiology Research
Hearing Defects
Vestibular Defects

Sensorineural Research
Hearing Defects
Vestibular Defects

Genes & Alleles

Gene & Allele Information provided by MGI

Allele Symbol		Sobpjc
Allele Name		Jackson circler
Allele Type		Spontaneous
Strain of Origin		C57BL/6J
Gene Symbol and Name		Sobp, sine oculis-binding protein homolog (Drosophila)
Chromosome		10
Gene Common Name(s)		2900009C16Rik; 5330439J01Rik; JXC1; Jackson circler; MRAMS; RIKEN cDNA 2900009C16 gene; RIKEN cDNA 5330439J01 gene; jc;
General Note		Homozygotes show erratic circling behavior which becomes more pronounced with age. They can swim. They are very active, bobbing up and down and flexing head and trunk ventrally towards the tail. Flexing behavior when suspended by tail is diagnostic at weaning age. jc is not allelic with other circling mutants on Chr 10 (J:13506).
Molecular Note		A 10 bp deletion is found in exon 6 eliminating nucleotides 1346-1355 of the BC059851 coding sequence. This results in the deletion of 48% of the protein. [MGI Ref ID J:137716]

Genotyping

Genotyping Information

Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Additional References

Sobp^jc related

Calderon A; Derr A; Stagner BB; Johnson KR; Martin G; Noben-Trauth K. 2006. Cochlear developmental defect and background-dependent hearing thresholds in the Jackson circler (jc) mutant mouse. Hear Res 221(1-2):44-58. [PubMed: 16962269]  [MGI Ref ID J:113021]

Chen Z; Montcouquiol M; Calderon R; Jenkins NA; Copeland NG; Kelley MW; Noben-Trauth K. 2008. Jxc1/Sobp, encoding a nuclear zinc finger protein, is critical for cochlear growth, cell fate, and patterning of the organ of corti. J Neurosci 28(26):6633-41. [PubMed: 18579736]  [MGI Ref ID J:137716]

Jones SM; Johnson KR; Yu H; Erway LC; Alagramam KN; Pollak N; Jones TA. 2005. A quantitative survey of gravity receptor function in mutant mouse strains. J Assoc Res Otolaryngol 6(4):297-310. [PubMed: 16235133]  [MGI Ref ID J:116914]

Southard JL. 1970. Jackson circler, jc. Mouse News Lett 42:30.  [MGI Ref ID J:13506]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, RG10/RG30.

Purchasing information

Pricing, Supply Level & Notes, Controls

General Supply Notes

• This strain is included in the Mouse Mutant Resource collection.
• Genomic DNA is available for this strain from the Mouse DNA Resource.

Control Information

	Control
	Heterozygote from the colony
Considerations for Choosing Controls
Control Pricing Information for Genetically Engineered Mutant Strains.

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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

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